CN110448343A - Upper digestive tract Cell collection device - Google Patents
Upper digestive tract Cell collection device Download PDFInfo
- Publication number
- CN110448343A CN110448343A CN201910791318.9A CN201910791318A CN110448343A CN 110448343 A CN110448343 A CN 110448343A CN 201910791318 A CN201910791318 A CN 201910791318A CN 110448343 A CN110448343 A CN 110448343A
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- Prior art keywords
- air bag
- gas tube
- capsule
- ball
- acquisition ball
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- 210000001035 gastrointestinal tract Anatomy 0.000 title claims abstract description 48
- 239000002775 capsule Substances 0.000 claims abstract description 62
- 239000007788 liquid Substances 0.000 claims abstract description 16
- 230000008859 change Effects 0.000 claims description 8
- 239000000463 material Substances 0.000 claims description 8
- 239000004814 polyurethane Substances 0.000 claims description 7
- 229920002635 polyurethane Polymers 0.000 claims description 6
- 230000029087 digestion Effects 0.000 claims description 3
- 238000004090 dissolution Methods 0.000 claims description 3
- 210000004027 cell Anatomy 0.000 abstract description 42
- 210000002784 stomach Anatomy 0.000 abstract description 26
- 238000000034 method Methods 0.000 abstract description 14
- 230000008569 process Effects 0.000 abstract description 11
- 210000002836 epithelial cell of stomach Anatomy 0.000 abstract description 4
- 210000000214 mouth Anatomy 0.000 abstract description 4
- 230000009747 swallowing Effects 0.000 abstract description 4
- 210000001156 gastric mucosa Anatomy 0.000 abstract description 3
- 238000010586 diagram Methods 0.000 description 12
- 241000167880 Hirundinidae Species 0.000 description 4
- 238000007689 inspection Methods 0.000 description 4
- 238000012545 processing Methods 0.000 description 4
- 238000001839 endoscopy Methods 0.000 description 3
- 210000002919 epithelial cell Anatomy 0.000 description 3
- 235000013305 food Nutrition 0.000 description 3
- 208000019505 Deglutition disease Diseases 0.000 description 2
- 230000005540 biological transmission Effects 0.000 description 2
- 239000000284 extract Substances 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 108010010803 Gelatin Proteins 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 238000005273 aeration Methods 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 210000001072 colon Anatomy 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 210000001198 duodenum Anatomy 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 210000003405 ileum Anatomy 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 210000001630 jejunum Anatomy 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 230000001151 other effect Effects 0.000 description 1
- 210000003800 pharynx Anatomy 0.000 description 1
- 210000000664 rectum Anatomy 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000033764 rhythmic process Effects 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 238000000082 states acquisition Methods 0.000 description 1
- 230000001360 synchronised effect Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
- A61B10/02—Instruments for taking cell samples or for biopsy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
- A61B10/0045—Devices for taking samples of body liquids
- A61B2010/0061—Alimentary tract secretions, e.g. biliary, gastric, intestinal, pancreatic secretions
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medical Informatics (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pathology (AREA)
- Molecular Biology (AREA)
- Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Surgical Instruments (AREA)
Abstract
A kind of upper digestive tract Cell collection device, including acquisition ball, gas tube and capsule are disclosed, acquisition ball includes air bag and the spongy layer that air bag periphery is arranged in, and gas tube is connect with air bag, and acquisition ball is placed in capsule after being compressed.When use, patient is by capsule swallowed whole, and one end of gas tube is stayed in outside oral cavity, capsule, which dissolves in the stomach, releases acquisition ball, spongy layer absorbs the liquid expansion in stomach, is inflated by gas tube to air bag, expands acquisition ball further, when peristole, acquisition ball and gastric mucosa surface are come into full contact with to acquire stomach cell.It after the scheduled time, is evacuated by gas tube, makes to acquire sphere volume diminution, drawing gas tube will acquire ball and orally take out by oesophagus, and acquisition ball collects esophageal cells with the abundant CONTACT WITH FRICTION of oesophageal surface in the process by oesophagus.Patient only needs once the process of swallowing that can acquire the epithelial cell of stomach and oesophagus as a result, improves the efficiency of upper digestive tract cell collection, reduces the pain of patient.
Description
Technical field
The present invention relates to medical instruments fields, and in particular to a kind of upper digestive tract Cell collection device.
Background technique
The upper digestive tract cell for clinically usually needing to acquire patient detects, and presently used method is to do digestion
The endoscopy or Capsule Endoscopy in road.Superior gastrointestinal endoscopy is a kind of invasive inspection, and patient often experiences bad.And
Though capsule endoscope is noninvasive test, the cell specimen of upper digestive tract can not be obtained simultaneously.Once someone was by having swallowed connecting line
Capsule sponge ball, capsule releases sponge ball after entering stomach, is then taken out sponge ball by drawing connecting line, to receive
Collect oesophageal surface cells.But since oesophagus caliber is small, and gastral cavity is larger, therefore the limited diameter of sponge ball, cannot fill with stomach inner wall
Tap is touched and acquires stomach surface cell.
Summary of the invention
In view of this, the present invention provides a kind of upper digestive tract Cell collection device, the size for acquiring ball is adjustable, can
It is sufficiently contacted with upper digestive tract to acquire upper digestive tract cell.
The upper digestive tract Cell collection device of the embodiment of the present invention, comprising:
Ball, including air bag and spongy layer are acquired, the spongy layer is arranged in the air bag periphery, for acquiring subject's
Upper digestive tract cell；
Gas tube is connect with the air bag, by air bag described in steering be filled with gas or from the air bag be discharged gas with
Change the volume of the air bag；And
Capsule is configured as wrapping up the air bag and spongy layer, and the capsule is using the material system that can be digested liquid dissolution
It is standby.
Preferably, described device further includes capsule type endoscope, is connected to the acquisition ball by connecting line, or with institute
It states acquisition spherical shape to be integrally formed, or the gas tube is connected to by connecting line.
Preferably, the air bag is annular.
Preferably, the middle vacancy of the air bag of annular is arranged in the capsule type endoscope.
Preferably, the spongy layer is configured to absorb the liquid of upper digestive tract and expand, and makes the acquisition ball
Volume increases.
Preferably, the spongy layer is specially polyurethane sponge.
Preferably, the spongy layer absorb after liquid sufficiently expands with a thickness of 1 centimetre.
Preferably, it is 3 centimetres that the air bag, which is filled with the maximum gauge after gas,.
Preferably, the length of the gas tube is configured as the length greater than upper digestive tract.
Preferably, the outer diameter of the gas tube is 1.5 millimeters.
The upper digestive tract Cell collection device of the embodiment of the present invention, including acquisition ball, gas tube and capsule, acquisition ball include
Air bag and the spongy layer that air bag periphery is arranged in, gas tube are connect with air bag, and acquisition ball is placed in capsule after being compressed.It uses
When, patient stays in outside oral cavity by capsule swallowed whole, and by one end of gas tube, and capsule, which dissolves in the stomach, releases acquisition ball,
Spongy layer absorb upper digestive tract in liquid expansion, inflated by gas tube into air bag, make acquire ball further expand and with
Gastric mucosa surface comes into full contact with to acquire stomach cell.It after the scheduled time, is evacuated by gas tube, makes to acquire sphere volume
It reduces, drawing gas tube will acquire ball and orally be taken out by oesophagus, and acquisition ball during oesophagus with oesophageal surface by sufficiently rubbing
It wipes contact and collects esophageal cells.Patient only needs once the process of swallowing that can acquire the epithelial cell of stomach and oesophagus as a result, mentions
The high efficiency of upper digestive tract cell collection, reduces the pain of patient.
Detailed description of the invention
By referring to the drawings to the description of the embodiment of the present invention, the above and other purposes of the present invention, feature and
Advantage will be apparent from, in the accompanying drawings:
Fig. 1 is the structural schematic diagram of the upper digestive tract Cell collection device of first embodiment of the invention；
Fig. 2 is the partial enlargement at the acquisition ball and capsule of the upper digestive tract Cell collection device of first embodiment of the invention
Schematic diagram；
Fig. 3 is the operation principle schematic diagram of the upper digestive tract Cell collection device of first embodiment of the invention；
Fig. 4 is that the state in the acquisition ball course of work of the upper digestive tract Cell collection device of first embodiment of the invention becomes
Change schematic diagram；
Fig. 5 is the structural schematic diagram of the upper digestive tract Cell collection device of second embodiment of the invention；
Fig. 6 is the structural schematic diagram of the upper digestive tract Cell collection device of third embodiment of the invention；
Description of symbols:
1- acquires ball；11- air bag；12- spongy layer；2- gas tube；3- capsule；4- capsule type endoscope；5- connecting line.
Specific embodiment
Below based on embodiment, present invention is described, but the present invention is not restricted to these embodiments.Under
Text is detailed to describe some specific detail sections in datail description of the invention.Do not have for a person skilled in the art
The present invention can also be understood completely in the description of these detail sections.In order to avoid obscuring essence of the invention, well known method, mistake
There is no narrations in detail for journey, process, element and circuit.
In addition, it should be understood by one skilled in the art that provided herein attached drawing be provided to explanation purpose, and
What attached drawing was not necessarily drawn to scale.
Unless the context clearly requires otherwise, otherwise the similar word such as "include", "comprise" in entire application documents should solve
It is interpreted as the meaning for including rather than exclusive or exhaustive meaning；That is, the meaning for being " including but not limited to ".
In the description of the present invention, it is to be understood that, term " first ", " second " etc. are used for description purposes only, without
It can be interpreted as indication or suggestion relative importance.In addition, in the description of the present invention, unless otherwise indicated, the meaning of " multiple "
It is two or more.
Unless otherwise clearly defined and limited, the terms such as term " installation ", " connected ", " connection ", " fixation " should be done extensively
Reason and good sense solution may be a detachable connection for example, it may be being fixedly connected, or integral；It can be mechanical connection, it can also be with
It is electrical connection；Can be directly connected, can also indirectly connected through an intermediary, can be connection inside two elements or
The interaction relationship of two elements, unless otherwise restricted clearly.For the ordinary skill in the art, Ke Yigen
The concrete meaning of above-mentioned term in the present invention is understood according to concrete condition.
When an element or layer are mentioned as in another element or layer "upper", " being engaged to ", " being connected to " or " coupled
To " another element or when layer, can directly on another element or layer, directly be engaged, be connected or coupled to another element or
Layer, or intermediary element or layer may be present.In contrast, when an element be mentioned as " direct " another element or layer "upper",
When " being bonded directly to ", " being directly coupled to " or " being directly coupled to " another element or layer, intermediary element may not be present
Or layer.Other words for describing relationship between element should be explained in a similar manner (for example, " between " with " directly exist
Between ", " neighbouring " and " being directly adjacent to " etc.).As used herein, term "and/or" includes one or more associated listed
Any or all combinations in project.
For ease of explanation, such as "inner", "outside", " under ", " lower section ", " lower part ", " top ", " top " etc. space
The relationship of an elements or features and another elements or features that relational language be used to describe to illustrate in figure herein.It will be understood that
It is that space correlation term may be intended to the different sides in addition to the orientation described in figure comprising equipment in use or operation
Position.For example, if the equipment in figure is reversed, be described as be in the elements of other elements or features " below " or " under " in
It is that will be positioned in other elements or features " top ".Thus, exemplary term " lower section " can include above and below side
Both positions.Equipment can be directed (be rotated by 90 ° or at other orientations), and space phase as used herein in other ways
Closing descriptor should be interpreted accordingly.
Embodiment one:
Fig. 1 is the structural schematic diagram of the upper digestive tract Cell collection device of the present embodiment, and Fig. 2 is the upper digestion of the present embodiment
Partial enlargement diagram at the acquisition ball and capsule of road Cell collection device.As depicted in figs. 1 and 2, the present embodiment on disappear
Changing road Cell collection device includes acquisition ball 1, gas tube 2 and capsule 3, and acquisition ball 1 includes air bag 11 and is arranged outside air bag 11
The spongy layer 12 in week, gas tube 2 are connect with air bag 11.Acquisition ball 1 is fitted into the capsule 3 after being compressed, and gas tube 2 is from capsule
Hole on 3 is stretched out.The capsule 3 for being wrapped in acquisition ball 1 enters dissolved, release acquisition ball 1 after stomach.By gas tube 2 to gas
The gas that capsule 11 is filled with gas or is discharged in air bag 11, thus it is possible to vary the volume of acquisition ball 1, to make to acquire the increase of 1 volume of ball
And convenient for acquisition upper digestive tract cell, or make to acquire the reduction of 1 volume of ball and be convenient for being drawn out by oesophagus.
Optionally, spongy layer 12 can be fixedly connected with the outer wall of air bag 11, to keep spongy layer 12 synchronous with air bag 11
Expansion is shunk.
In another embodiment, spongy layer 12 and air bag 11 are fixedly connected with gas tube 2 respectively.
In this embodiment, it is preferred that spongy layer 12 is polyurethane (PU, polyurethane) sponge, polyurethane sponge
With excellent biocompatibility, property nontoxic to the human body is consequently adapted to be placed into upper digestive tract, and polyurethane sponge is soft
And high resilience, change suitable for 11 periphery of air bag is arranged in the volume change of air bag 11.Certainly, those skilled in the art
Also other effects harmless to the human body be can choose and be suitable for absorbing the flexible material production spongy layer 12 of liquid expansion.Air bag 11
It can be made of the medical macromolecular materials that elasticity is good, those skilled in the art can select 11 material of air bag according to the actual situation
Specific type.
Capsule 3 is made of the edible material that can be digested liquid dissolution, for example, gelatin, starch or other materials.It uses
When, patient swallows the capsule 3 for being wrapped in acquisition ball 1, and capsule 3 enters stomach, is dissolved by the liquid in stomach and discharges acquisition ball
1, acquisition ball 1 is fitted into capsule 3 and can be swallowed convenient for patient, spongy layer 12 is also possible to prevent and is absorbed during patient swallows
Liquid expansion is excessive and dysphagia occurs.
In another optional embodiment, the upper digestive tract Cell collection device also may not include capsule 3, patient
Directly compressed acquisition ball 1 is swallowed into upper digestive tract.
Gas tube 2 can be made of the preferable medical macromolecular materials of toughness (for example, silica gel), it is preferable that can inflate
Wire is set on the tube wall of pipe 2 or in tube wall, to increase the intensity of gas tube 2, gas tube 2 is prevented to be broken when in use.
One end of gas tube 2 is connect with air bag 11, and the other end with feeder (such as small-sized air pump for medical) for connecting.Gas tube 2
Length must be greater than the length of human body upper digestive tract so that the other end of gas tube 2 is exposed to after acquisition ball 1 enters upper digestive tract
Outside human body.The diameter of gas tube 2 should be less than the diameter of oesophagus, so that gas tube 2 can smoothly enter into upper digestive tract.Preferably, it fills
The diameter of tracheae 2 is 1.5 millimeters, both can guarantee that described device can be swallowed smoothly, and also can prevent caliber is too small to cause to air bag
11 inflated for deflated efficiency are too low.
Fig. 3 is the operation principle schematic diagram of the upper digestive tract Cell collection device of the present embodiment, and Fig. 4 is the upper of the present embodiment
State change schematic diagram in the acquisition ball course of work of alimentary canal Cell collection device.Fig. 3 schematically illustrates this implementation
The use process of the device of example, Fig. 4 schematically illustrate the change in shape that described device acquires ball 1 in use, Fig. 3
With the structure that capsule 3 is not shown in Fig. 4.Illustrate the upper digestive tract cell collection of the present embodiment below in conjunction with Fig. 3 and Fig. 4
The course of work of device.
When in use, patient swallows ball 1 is acquired, and the other end of gas tube 2 is exposed to outside oral cavity.It acquires ball 1 and enters stomach
Behind portion, capsule 3 is dissolved by the liquid of stomach, releases acquisition ball 1, and spongy layer 12 absorbs the liquid in stomach and expands.Preferably,
The spongy layer 12 absorb after liquid sufficiently expand with a thickness of 1 centimetre, to prevent the diameter for acquiring ball 1 is excessive to be difficult to pass through food
Pipe is removed, and certainly, spongy layer 12 can also be designed as other not according to the actual situation by those skilled in the art to be influenced normally
The size used.Gas tube 2 is exposed to external one end and connect with feeder, and feeder passes through gas tube 2 to air bag 11
It is filled with gas, increases the volume for acquiring ball 1.Preferably, it is 3 centimetres that air bag 11, which is filled with the maximum gauge after gas, that is, acquisition
The maximum gauge of ball 1 is 5 centimetres, acquisition ball 1 can be made sufficiently to contact with stomach inner wall and acquire cell, while preventing volume mistake
Biggish pressure is generated to stomach greatly and patient is made to generate discomfort, aeration quantity can be controlled according to the actual conditions of patient to control
Acquire the volume of ball 1.Certainly, air bag 11 can also be designed as other not according to the actual situation by those skilled in the art influences just
The size being often used.With the wriggling of stomach, acquires ball 1 and move in stomach and squeezed by stomach repeatedly, to be filled with stomach wall surface
Divide CONTACT WITH FRICTION, collects the epithelial cell of stomach.(for example, 30 minutes) after a period of time, acquisition ball 1 with stomach inner wall
It comes into full contact with, feeder extracts the gas in air bag 11 out by gas tube 2, is contracted to the diameter for acquiring ball 1 slightly larger than food
Then pipe caliber pulls gas tube 2 for acquisition ball 1 and passes through and orally take out acquisition ball 1 from upper digestive tract, makes to adopt in the process
Collect the abundant CONTACT WITH FRICTION of inner wall of ball 1 and oesophagus, collects the epithelial cell at oesophagus.Thus, it is only necessary to once swallow process
The collection for completing the epithelial cell at stomach and oesophagus two, achievees the purpose that noninvasive collection upper digestive tract epithelial cell.This field skill
Art personnel can extract the inspection that upper digestive tract cell carries out next step from spongy layer 12 using routine experiment means, can be used for
It digests the early screening of tumour or meets other test needs.
The upper digestive tract Cell collection device of the embodiment of the present invention, including acquisition ball, gas tube and capsule, acquisition ball include
Air bag and the spongy layer that air bag periphery is arranged in, gas tube are connect with air bag, and acquisition ball is placed in capsule after being compressed.It uses
When, patient stays in outside oral cavity by capsule swallowed whole, and by one end of gas tube, and capsule, which dissolves in the stomach, releases acquisition ball,
Spongy layer absorb upper digestive tract in liquid expansion, inflated by gas tube into air bag, make acquire ball further expand and with
Gastric mucosa surface comes into full contact with to acquire stomach cell.It after the scheduled time, is evacuated by gas tube, makes to acquire sphere volume
It reduces, drawing gas tube will acquire ball and orally be taken out by oesophagus, and acquisition ball during oesophagus with oesophageal surface by sufficiently rubbing
It wipes contact and collects esophageal cells.Patient only needs once the process of swallowing that can acquire the epithelial cell of stomach and oesophagus as a result, mentions
The high efficiency of upper digestive tract cell collection, reduces the pain of patient.
Embodiment two:
Fig. 5 is the structural schematic diagram of the upper digestive tract Cell collection device of the present embodiment.As shown in figure 5, the present embodiment
Upper digestive tract Cell collection device and the difference of embodiment one are that the embodiment of the present invention device further includes capsule type endoscope
4 and connecting line 5.
Capsule type endoscope is a kind of endoscope for being made into capsule shape.When being checked, patient uses as medication
After water swallows capsule type endoscope, it is i.e. as the movement rhythm of stomach and intestine muscle passes sequentially through gastral each structure (food
Pipe, Stomach duodenum, jejunum and ileum, colon, rectum), in this process, while the gastrointestinal tract of process is carried out continuous
Camera shooting.Capsule endoscope can be discharged outside patient body for 1 to 3 day after swallowing.Typical capsule type endoscope is made of seven parts, thoroughly
Bright shell, light source, image-forming component, sensor, battery, transmitting module and antenna composition.Circuit system contains sensor inspection again
Survey component, Signal Processing Element and wireless transmission component.The sensor sensing elements such as image, temperature, pH value detect in alimentary canal
Information, the information are sent in vitro by the processing of Signal Processing Element through wireless transmission component.External receiver receives signal,
By the processing of extracorporeal treatment unit, shown in terminal.
In a kind of optional embodiment, capsule type endoscope 4 is fixedly connected with connecting line 5, connecting line 5 and gas tube
2 are fixedly connected, and the position of capsule type endoscope 4 is arranged close to the place of acquisition ball 1.It is considerable by capsule type endoscope 4
It examines the state of patient's upper digestive tract and acquires the state of ball 1, the position and residence time for acquiring ball 1 can be adjusted,
Also it can simplify checking process.Meanwhile the patient for only needing to carry out upper digestive tract capsule type endoscope inspection, it is checking out
Capsule type endoscope 4 and acquisition ball 1 are taken out together after, so as to avoid conventional capsule-type endoscope from being discharged by enteron aisle
Shi Fasheng is stuck in the situation in enteron aisle.
In another optional embodiment, one end of connecting line 5 is fixedly connected with acquisition ball 1, the other end and capsule
Type endoscope 4 is fixedly connected.
Capsule 3 both can only wrap up acquisition ball 1, can also wrap up acquisition ball 1 and capsule type endoscope 4 wherein.Certainly,
Under the premise of patient can smoothly swallow, it can also be not provided with capsule 3, and patient is allowed directly to swallow described device.
The gas tube 2 of the embodiment of the present invention device and the structure of acquisition ball 1 are consistent in embodiment one, herein no longer
It repeats.
Embodiment three:
Fig. 6 is the structural schematic diagram of the upper digestive tract Cell collection device of the present embodiment.As shown in fig. 6, the present embodiment
Upper digestive tract Cell collection device and the difference of embodiment one to embodiment two are that the embodiment of the present invention device includes capsule
Type endoscope 4, air bag 11 are annular.Capsule type endoscope 4 may be provided at the inner ring of annular air-pocket 11 far from one end of camera
It above and with air bag 11 is fixedly connected, the inner ring diameter of air bag 11 and the size of capsule type endoscope 4 are adapted.Spongy layer 12 is arranged
Air bag 11 periphery and do not wrap up the camera part of capsule type endoscope 4.Correspondingly, the size of air bag 11 and spongy layer 12
Size should correspondingly reduce, to prevent patient's dysphagia.Thus, it is possible to keep the structure of described device more compact, simultaneously
Also capsule type endoscope can preferably be controlled.Acquisition ball 1 and capsule type endoscope 4 are placed in capsule 3, can be gulped down convenient for patient
Pharynx.
The structure of the gas tube 2 of the embodiment of the present invention device is consistent into embodiment two with embodiment one, herein not
It repeats again.
The above description is only a preferred embodiment of the present invention, is not intended to restrict the invention, for those skilled in the art
For, the invention can have various changes and changes.All any modifications made within the spirit and principles of the present invention are equal
Replacement, improvement etc., should all be included in the protection scope of the present invention.
Claims (10)
1. a kind of upper digestive tract Cell collection device characterized by comprising
It acquiring ball (1), including air bag (11) and spongy layer (12), the spongy layer (12) is arranged in the air bag (11) periphery,
For acquiring the upper digestive tract cell of subject；
Gas tube (2) is connect with the air bag (11), is filled with gas by air bag described in steering (11) or from the air bag (11)
Gas is discharged to change the volume of the air bag (11)；And
Capsule (3) is configured as wrapping up the acquisition ball (1), and the capsule (3) is using the material system that can be digested liquid dissolution
It is standby.
2. the apparatus according to claim 1, which is characterized in that described device further include:
Capsule type endoscope (4) is connected to the acquisition ball (1) by connecting line, or is formed as one with the acquisition ball (1)
Body, or the gas tube (2) are connected to by connecting line.
3. the apparatus of claim 2, which is characterized in that the air bag (11) is annular.
4. device according to claim 3, which is characterized in that the air bag of annular is arranged in the capsule type endoscope (4)
(11) middle vacancy.
5. the apparatus according to claim 1, which is characterized in that the spongy layer (12) is configured to absorb digestion
The liquid in road and expand, make it is described acquisition ball (1) volume increase.
6. device according to claim 5, which is characterized in that the spongy layer (12) is specially polyurethane sponge.
7. device according to claim 5, which is characterized in that the spongy layer (12) absorbs the thickness after liquid sufficiently expands
Degree is 1 centimetre.
8. the apparatus according to claim 1, which is characterized in that it is 3 that the air bag (11), which is filled with the maximum gauge after gas,
Centimetre.
9. the apparatus according to claim 1, which is characterized in that the length of the gas tube (2), which is configured as being greater than, above to disappear
Change the length in road.
10. the apparatus according to claim 1, which is characterized in that the outer diameter of the gas tube (2) is 1.5 millimeters.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910791318.9A CN110448343A (en) | 2019-08-26 | 2019-08-26 | Upper digestive tract Cell collection device |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910791318.9A CN110448343A (en) | 2019-08-26 | 2019-08-26 | Upper digestive tract Cell collection device |
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| CN110448343A true CN110448343A (en) | 2019-11-15 |
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| CN201910791318.9A Pending CN110448343A (en) | 2019-08-26 | 2019-08-26 | Upper digestive tract Cell collection device |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113116397A (en) * | 2019-12-30 | 2021-07-16 | 上海科罡医疗技术有限公司 | Esophageal wall cell sampler |
| CN114209362A (en) * | 2022-01-27 | 2022-03-22 | 湖南港湾科学仪器有限公司 | Gastric juice and esophagus cell collector in stomach |
| CN117481708A (en) * | 2023-12-29 | 2024-02-02 | 深圳市康达安生物科技有限公司 | Cervical brush with end head protection function and application method thereof |
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| CN2198877Y (en) * | 1994-07-05 | 1995-05-31 | 刘玉奇 | Ball for taking stomach cells |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN113116397A (en) * | 2019-12-30 | 2021-07-16 | 上海科罡医疗技术有限公司 | Esophageal wall cell sampler |
| CN113116397B (en) * | 2019-12-30 | 2023-02-28 | 上海科罡医疗技术有限公司 | Esophageal wall cell sampler |
| CN114209362A (en) * | 2022-01-27 | 2022-03-22 | 湖南港湾科学仪器有限公司 | Gastric juice and esophagus cell collector in stomach |
| CN117481708A (en) * | 2023-12-29 | 2024-02-02 | 深圳市康达安生物科技有限公司 | Cervical brush with end head protection function and application method thereof |
| CN117481708B (en) * | 2023-12-29 | 2024-03-22 | 深圳市康达安生物科技有限公司 | Cervical brush with end head protection function and application method thereof |
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