CN110420389A - A kind of the visual cortex localization method and device of transcranial magnetic stimulation - Google Patents
A kind of the visual cortex localization method and device of transcranial magnetic stimulation Download PDFInfo
- Publication number
- CN110420389A CN110420389A CN201910738600.0A CN201910738600A CN110420389A CN 110420389 A CN110420389 A CN 110420389A CN 201910738600 A CN201910738600 A CN 201910738600A CN 110420389 A CN110420389 A CN 110420389A
- Authority
- CN
- China
- Prior art keywords
- stimulated
- person
- magnetic stimulation
- transcranial magnetic
- visual cortex
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000011491 transcranial magnetic stimulation Methods 0.000 title claims abstract description 42
- 238000000034 method Methods 0.000 title claims abstract description 35
- 210000000857 visual cortex Anatomy 0.000 title claims abstract description 29
- 230000004807 localization Effects 0.000 title claims abstract description 17
- 210000004556 brain Anatomy 0.000 claims abstract description 20
- 238000012937 correction Methods 0.000 claims abstract description 13
- 230000004438 eyesight Effects 0.000 claims description 19
- 201000009487 Amblyopia Diseases 0.000 claims description 13
- 238000005259 measurement Methods 0.000 claims description 8
- 210000003625 skull Anatomy 0.000 claims description 4
- 241000208340 Araliaceae Species 0.000 claims 1
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 claims 1
- 235000003140 Panax quinquefolius Nutrition 0.000 claims 1
- 235000008434 ginseng Nutrition 0.000 claims 1
- 210000001178 neural stem cell Anatomy 0.000 claims 1
- 230000000638 stimulation Effects 0.000 abstract description 20
- 238000012360 testing method Methods 0.000 abstract description 7
- 238000007689 inspection Methods 0.000 abstract description 5
- 238000010276 construction Methods 0.000 abstract description 4
- 230000006870 function Effects 0.000 abstract description 4
- 210000003484 anatomy Anatomy 0.000 abstract description 3
- 230000021317 sensory perception Effects 0.000 abstract description 3
- 238000009102 step therapy Methods 0.000 abstract 1
- 210000003128 head Anatomy 0.000 description 19
- 238000011161 development Methods 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 210000000337 motor cortex Anatomy 0.000 description 4
- 230000000007 visual effect Effects 0.000 description 4
- 210000003311 CFU-EM Anatomy 0.000 description 3
- 210000003710 cerebral cortex Anatomy 0.000 description 3
- 230000033001 locomotion Effects 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 206010001497 Agitation Diseases 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 230000000763 evoking effect Effects 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 210000003205 muscle Anatomy 0.000 description 2
- 230000004379 myopia Effects 0.000 description 2
- 208000001491 myopia Diseases 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 230000004936 stimulating effect Effects 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- 229930091051 Arenine Natural products 0.000 description 1
- XYFCBTPGUUZFHI-UHFFFAOYSA-N Phosphine Chemical compound P XYFCBTPGUUZFHI-UHFFFAOYSA-N 0.000 description 1
- 206010034962 Photopsia Diseases 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000002146 bilateral effect Effects 0.000 description 1
- 210000005252 bulbus oculi Anatomy 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000002224 dissection Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 210000000744 eyelid Anatomy 0.000 description 1
- JEIPFZHSYJVQDO-UHFFFAOYSA-N ferric oxide Chemical compound O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 description 1
- 210000001595 mastoid Anatomy 0.000 description 1
- 230000004630 mental health Effects 0.000 description 1
- 210000000103 occipital bone Anatomy 0.000 description 1
- 210000000869 occipital lobe Anatomy 0.000 description 1
- 229910000065 phosphene Inorganic materials 0.000 description 1
- 238000013102 re-test Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 238000013548 repetitive transcranial magnetic stimulation Methods 0.000 description 1
- 210000004761 scalp Anatomy 0.000 description 1
- 210000003786 sclera Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N2/00—Magnetotherapy
- A61N2/004—Magnetotherapy specially adapted for a specific therapy
- A61N2/006—Magnetotherapy specially adapted for a specific therapy for magnetic stimulation of nerve tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N2/00—Magnetotherapy
- A61N2/02—Magnetotherapy using magnetic fields produced by coils, including single turn loops or electromagnets
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Magnetic Treatment Devices (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
Abstract
The present invention provides a kind of visual cortex localization methods of transcranial magnetic stimulation, and stimulus intensity correction and stimulation target spot based on the special sensory perception characteristic of visual cortex position, and obtain the double-point information of person's visual cortex function and anatomical structure to be stimulated, accurate positioning.The present invention provides the keyboards being connected on rTMS state modulator platform, and oral typing can be replaced by key, to reduce a possibility that head is mobile, further increase the accuracy of positioning, improve the efficiency of next step therapy intervention.The present invention is used since stimulus threshold PT average value intensity, it is incremented by step by step with 2% gradient, it is aided with the method for test inspection, sufficiently incorporate the information of the brain shape of person to be stimulated, brain anatomic construction, three aspect of brain domain positioning, the accuracy that ensure that positioning, better than the simple TMS localization method carried out using brain information in a certain respect in the prior art.
Description
Technical field
The invention belongs to medical ancillary technique field more particularly to the visual cortex localization methods and dress of a kind of transcranial magnetic stimulation
It sets.
Background technique
According to the estimation of WHO in 2005, the whole world has 1.24 hundred million people with amblyopia (WHO epidemiology 2005), and China is adult
Amblyopia person to be stimulated is about 30,000,000 people, and children's myopia is about 10,000,000 people, and children's myopia recall rate is about 0.81-2.8%.It is weak
There is no organic diseases for eye-construction itself depending on person to be stimulated, it anomaly occurs in visual cortex, is and visual development phase
The disease of pass.As the most common reason of Children and teenager monocular vision decline, amblyopia not only brings many in life
Inconvenience influences the ability of study, social and movement etc., also has negatively to mental health, individual and socio-economic development
It influences.Therefore, effective treatment means are researched and developed and reverse inpairment of vision, not only can largely Economy type medicines and society pay wages, significantly subtract
The burden of few tender, can also be effectively improved the socio-economic status of person to be stimulated.Since traditional amblyopia treatment method is to missing
The amblyopia of visual development critical period person's curative effect to be stimulated is little, after the critical period treatment of amblyopia be in current vision research field urgently
Problem to be solved.Repetitive transcranial magnetic stimulation rTMS is expected to the regulating and controlling effect of cerebral cortex function by it to become potential weak
Depending on intervention means.However, the method for previously having no visual cortex positioning, what document report was crossed is mainly the method according to motor cortex
Operation.
Summary of the invention
For above-mentioned deficiency in the prior art, a kind of visual cortex localization method of transcranial magnetic stimulation provided by the invention and
Device solves the problems, such as to carry out amblyopia person to be stimulated location difficulty when rTMS intervention.
In order to reach the goals above, the technical solution adopted by the present invention are as follows:
This programme provides a kind of visual cortex localization method of transcranial magnetic stimulation, includes the following steps:
S1, after amblyopia person's seat to be stimulated, make the head of person to be stimulated keep low level and being fixed with neck brace, and will hide
Light eyeshade and positioning cap are worn over person head to be stimulated, are held in position cap and are bonded with person head to be stimulated；
S2, by the handle of transcranial magnetic stimulation TMS coil upward, it is parallel with the linea vertebralis of person to be stimulated, will starting stimulation it is strong
Degree MSO is set as 80%, above the occipital protuberance center line of person to be stimulated from 4CM single-frame move TMS up and down
Coil finds vision hot spot；
S3, the corresponding position of the fixed vision hot spot, and turn down stimulus intensity, from low to high sequentially with 2% gradient
Stimulation；
S4, judge whether person to be stimulated optical illusion occurs, if occurring, S5 is entered step, conversely, then return step S3；
Stimulus intensity when S5, record optical illusion probability of occurrence are more than or equal to 50%, and the stimulus intensity is set as piercing
Swash threshold value PT；
S6, step S1-S5 is repeated after 24 hours, credit assigned is carried out to the stimulus threshold PT and is resurveyed；
S7, judge whether the Cronbach of the stimulus threshold PT after resurveying is more than or equal to 0.7, if so, completing view
Cortex positioning, conversely, then return step S1.
Further, the light for treating exciter's progress 40 minutes is needed to deprive before step S1.
Still further, the overlay mark of positioning cap described in the step S1 there are nine grids, and guarantee nine grid
Center face brain electric system in occipital region mid-point.
Still further, TMS coil and person's skull surface to be stimulated are tangent in the step S2, and person to be stimulated is not contacted
Head.
Still further, judging whether optical illusion occur in the step S4 method particularly includes:
Whether optical illusion is generated by the keyboard typing being connected on transcranial magnetic stimulation parameters console.
Still further, the expression formula of Cronbach a is as follows in the step S7:
Wherein, k indicates the sum of measure the item,Indicate the variance of i-th result,Indicate the side of overall measurement result
Difference
Based on the above method, the present invention also provides a kind of visual cortex positioning devices of transcranial magnetic stimulation, including intensity school
Positive TMS coil, positioning cap, nine grids being marked on the positioning cap, connect with the intensity correction TMS coil through cranium magnetic
Stimulation parameter console, and the keyboard being connect with the transcranial magnetic stimulation parameters console.
Further, the positioning cap is used to be worn over the head of person to be stimulated, for nine grids being marked on above
It is fixed；
The nine sides center of a lattice is for occipital region mid-point in face brain electric system；
The intensity correction TMS coil is used to find vision hot spot according to stimulus intensity；
The transcranial magnetic stimulation parameters console is for adjusting stimulus intensity；
Whether the keyboard observes the information of optical illusion for typing person to be stimulated.
Beneficial effects of the present invention:
(1) present invention is corrected by the stimulus intensity based on the special sensory perception characteristic of visual cortex and stimulation target spot positions, and is obtained
The double-point information of person's visual cortex function and anatomical structure to be stimulated is taken, precise positioning regards skin to amblyopia person to be stimulated to realize
The accurate stimulation of layer.In addition, the keyboard being connected on rTMS state modulator platform that the present invention is equipped with, can be replaced by key
Oral typing further increases the accuracy of positioning to reduce a possibility that head is mobile, mentions for the therapy intervention of next step
High efficiency.
(2) in stimulating slight correction course, the present invention is used since stimulus threshold PT average value intensity, with 2%
Gradient is incremented by step by step, is aided with the method for test inspection, sufficiently incorporate the brain shape of person to be stimulated, brain anatomic construction,
The information of three aspect of brain domain positioning, ensure that the accuracy of positioning, simple better than before to utilize brain information in a certain respect
The TMS localization method of progress.
Detailed description of the invention
Fig. 1 is flow chart of the method for the present invention.
Fig. 2 is the schematic diagram that stimulus threshold PT is resurveyed in the present embodiment.
Fig. 3 is control structure schematic diagram of the invention.
Wherein, 1- positioning cap, nine grid of 2-, 3- transcranial magnetic stimulation TMS coil, 4- transcranial magnetic stimulation TMS console, 5- key
Disk.
Specific embodiment
A specific embodiment of the invention is described below, in order to facilitate understanding by those skilled in the art this hair
It is bright, it should be apparent that the present invention is not limited to the ranges of specific embodiment, for those skilled in the art,
As long as various change is in the spirit and scope of the present invention that the attached claims limit and determine, these variations are aobvious and easy
See, all are using the innovation and creation of present inventive concept in the column of protection.
Embodiment
Transcranial magnetic stimulation (Transcranial Magnetic Stimulation, TMS), is that one kind passes through pulsed magnetic field
Electric current is generated in localized cerebral cortex with temporary activation or inhibits the technology of the cortex.The effect audient of transcranial magnetic stimulation TMS
Multifactor influence, including stimulation brain area, coil-type, impulse waveform, current direction and stimulus intensity, frequency of stimulation, thorn
Swash umber of pulse etc..Wherein, especially mostly important with stimulus intensity.By taking visual cortex as an example, high-intensitive TMS acts on occipital lobe and can produce
Optical illusion, and low intensive stimulation then generates instantaneous blind spot.In the case where guaranteeing that above-mentioned parameter is consistent, person to be stimulated is in skin
The individual that layer excitability, cerebral cortex configuration and skull shape (influencing scalp to corticocerebral distance) etc. are shown
Otherness, which can all significantly affect, can cause identical excitement to sexually revise transcranial magnetic stimulation TMS intensity required for effect to be therefore
Reduction individual difference bring difference on effect needs to carry out individual calibration to the stimulus intensity of transcranial magnetic stimulation TMS.So
And the method for previously having no visual cortex positioning is mainly to operate according to the method for motor cortex.Transcranial magnetic stimulation TMS intensity correction
It is most commonly in Motor stimulation threshold value (motor threshold, MT) continuous mode.When transcranial magnetic stimulation TMS is pierced with some strength
When swashing motor cortex, can corresponding target muscles be recorded Motion Evoked Potential (motor evoked potentials,
MEPs), usually at least 50% continuous experiment, so that target muscles generate the MEP institute that wave crest-peak amplitude difference is greater than 50 μ V
The minimum intensity needed is Motor stimulation threshold value, and MT largely reflects the excitability of motor cortex.In clinical research and
In, the importance of biopotency is greater than the output parameter of instrument, and therefore, stimulus intensity is usually with specific experiment object fortune
Multiple or the percentage of stimulus threshold are moved to indicate, this is the stimulus intensity after correcting.When TMS acts on visual cortex, due to
Similar electromyogram record can not be carried out, optical illusion need to be used to replace MEPs as Testing index, and then measure optical illusion stimulus threshold
It is worth (phosphene threshold, PT), determines stimulus intensity.In addition, being stimulated before stimulus threshold PT test
The region that most bright and most stable optical illusion sense can be generated after stimulation is referred to as " vision hot spot " (visual by Target localization
hotspot).The process needs the experience of this subjective vision of person's typing optical illusion to be stimulated.Therefore, the present invention will also be to through cranium magnetic
The stimulus intensity correcting scheme of TMS is stimulated to carry out test inspection (test-retest reliability), it is accurate to obtain
Positioning, and accurately stimulation stimulus threshold is provided for subsequent intervention.
As shown in Figure 1, to achieve the above object the present invention provides a kind of visual cortex localization method of transcranial magnetic stimulation,
Implementation method is as follows:
S1, after amblyopia person's seat to be stimulated, make the head of person to be stimulated keep low level and being fixed with neck brace, and will hide
Light eyeshade and positioning cap are worn over person head to be stimulated, are held in position cap and are bonded with person head to be stimulated.
In a particular embodiment, person to be stimulated sits on armchair, and head is kept low level and is fixed with neck brace, puts on shading
Eyeshade is in the environment of complete darkness, puts on the positioning cap being bonded completely with head, and positioning cap overlay mark has 1 ×
Nine grids of 3cm, if adult subject, can suitably expand location area, such as be changed to 25 grids of 5 × 5cm, nine grid centers are just
To dissection identification point Oz (occipital region mid-point in international standard lead 10-20 brain electric system), front and back electrical path length and (anterior
Posterior, Ap) and side length (lateral medial, Lm) measure and be averaged three times, this process need by
The anatomic markers point such as nasion, bilateral mastoid process and occipital protuberance is positioned, and the position between positioning cap and brainpan is one at this time
One is corresponding.
In a particular embodiment, to make person's accurate understanding optical illusion to be stimulated in step S1, with benefit subsequent positioning and threshold
Value measurement, in addition to language description, operator need to oppress the sclera portion of subject's eyeball with finger by eyelid before measurement starts,
And then the ring of light, i.e. optical illusion are generated in the diagonal direction of stimulation location.Stimulation can also give 40 minutes light before starting is deprived
(light deprivation), make subject can be more sensitive detect optical illusion.
S2, by the handle of transcranial magnetic stimulation TMS coil upward, it is parallel with the linea vertebralis of person to be stimulated, will starting stimulation it is strong
Degree MSO is set as 80%, above the occipital protuberance center line of person to be stimulated from 4CM single-frame move TMS up and down
Coil finds vision hot spot.
In a particular embodiment, person to be stimulated needs whole body to keep relaxation state, by transcranial magnetic stimulation TMS coil handle court
On, it is parallel with linea vertebralis, above the occipital protuberance median line from 4cm single-frame move transcranial magnetic stimulation TMS line up and down
Circle finds the optimum position --- --- " vision hot spot " that can cause optical illusion.In the process, coil should be tangent with skull surface
But person head to be stimulated is not contacted.It is 80%MSO (maximum stimulator output) by starting stimulus intensity, if to
The non-typing optical illusion of exciter occurs, and can suitably increase stimulus intensity, specifically, being moved step by step according to starting stimulus intensity MSO
Dynamic TMS coil finds vision hot spot.
S3, the corresponding position of the fixed vision hot spot, and turn down stimulus intensity, from low to high sequentially with 2% gradient
Stimulation；
S4, judge that optical illusion occurs in person to be stimulated person whether to be stimulated, if occurring, S5 is entered step, conversely, then returning to step
Rapid S3；
Stimulus intensity when S5, record optical illusion probability of occurrence are more than or equal to 50%, and the stimulus intensity is set as piercing
Swash threshold value PT.
In a particular embodiment, after searching out " vision hot spot ", stimulus intensity is turned down, sequentially stimulates and askes from low to high
Ask whether person to be stimulated optical illusion occurs, record optical illusion probability of occurrence is more than or equal to stimulus intensity when 50%, this is stimulated
Threshold value PT.During measuring stimulus threshold PT, the movement of head or coil will affect the assessment to threshold value.Especially stimulus threshold
Value PT needs whether the oral typing of person to be stimulated observes optical illusion when measuring, and is easier to cause the accurate of position moving influence result
Property.Therefore, the present invention is equipped with the keyboard being connected on rTMS state modulator platform to person to be stimulated, is replaced by key oral
It answers, to reduce a possibility that head is mobile.
S6, step S1-S5 is repeated after 24 hours, credit assigned is carried out to the stimulus threshold PT and is resurveyed；
S7, judge whether the Cronbach of the stimulus threshold PT after resurveying is more than or equal to 0.7, if so, completing view
Cortex positioning, conversely, the expression formula of Cronbach a is as follows in then return step S1, the step S7:
Wherein, k indicates the sum of measure the item,Indicate the variance of i-th result,Indicate the side of overall measurement result
Difference.
In a particular embodiment, as shown in Fig. 2, repeating step S1 to step S5 after 24 hours.Stimulation to measuring
Threshold value PT carries out test inspection, Cronbach's α coefficient (the Cronbach alpha of stimulus threshold PT
Coefficient) coefficient >=0.7 then shows measurement results reliability height, has good repeatability, and accurate positioning can press
Start to stimulate according to the site found before.
As shown in figure 3, it is based on the above method, the invention also discloses a kind of visual cortex positioning device of transcranial magnetic stimulation,
Including intensity correction TMS coil 3, positioning cap 1, nine grids 2 being marked on the positioning cap and the intensity correction TMS line
The transcranial magnetic stimulation parameters console 4 of 3 connection of circle, and the keyboard 5 being connect with the transcranial magnetic stimulation parameters console 4.Institute
Positioning cap 1 is stated for being worn over the head of person to be stimulated, for then nine grids of label above it to be fixed；Described nine
The center of grid 2 is for occipital region mid-point in face brain electric system；The intensity correction TMS coil 3 is used for according to stimulus intensity
Find vision hot spot；The transcranial magnetic stimulation parameters console 4 is for adjusting stimulus intensity；The keyboard 5 is cocked for typing
Whether sharp person observes the information of optical illusion.
The course of work of the present apparatus: after amblyopia person's seat to be stimulated, the head of person to be stimulated is made to keep low level and with neck brace
It is fixed, and eye-shade and positioning cap 1 is worn over person head to be stimulated, be held in position cap 1 and be bonded with person head to be stimulated,
Stationary positioned cap 1, it is upward by the handle of transcranial magnetic stimulation TMS coil 2, parallel with the linea vertebralis of person to be stimulated, starting is stimulated
Intensity MSO is set as 80%, and each markings and occipital region mid-point Oz are determined after parameter measurement, nine grids 2 are affixed on positioning cap 1
On, center must face occipital region mid-point Oz, i.e. occipital region mid-point in the 10-20 brain electric system of the world.From the occipital bone of person to be stimulated
The place 4CM starts single-frame to move TMS coil up and down and finds vision hot spot above knuckle center line, stimulation start it is preceding also can be to
Give 40 minutes light and deprive (light deprivation), enable person to be stimulated it is more sensitive detect optical illusion, carrying out
When vision hot spot is found and stimulus threshold PT is found, the tune of position or stimulus intensity is carried out according to the key result of person to be stimulated
It is whole." 1 ", " 0 " key on keyboard 5 respectively represent " having ", "None", as the result is shown in corresponding transcranial magnetic stimulation TMS console 4
On, record optical illusion probability of occurrence is more than or equal to stimulus intensity when 50%, i.e. stimulus threshold PT.To described after 24 hours
Stimulus threshold PT carries out resurveying for credit assigned, and judges whether the Cronbach of the stimulus threshold PT after resurveying is greater than
In 0.7, if it is greater than or equal to 0.7, then shows measurement results reliability height, there is good repeatability, accurate positioning can be according to
The site found before starts to stimulate.
RTMS is applied to miss the amblyopia person to be stimulated of visual development critical period, solve by the present invention by designing above
The problem of traditional visual cortex location difficulty.The present invention is based on the correction of the stimulus intensity of the special sensory perception characteristic of visual cortex and stimulations
Target spot positioning, obtains the double-point information of person's visual cortex function and anatomical structure to be stimulated, accurate positioning.In addition, the present invention is equipped with
The keyboard being connected on rTMS state modulator platform, oral answer can be replaced by key, with reduce head it is mobile can
Energy property, further increases the accuracy of positioning, improves efficiency for the therapy intervention of next step.Stimulating slight correction course
In, the present invention is used since stimulus threshold PT average value intensity, is incremented by step by step with 2% gradient, and test inspection is aided with
Method, sufficiently incorporate the information of the brain shape of person to be stimulated, brain anatomic construction, three aspect of brain domain positioning, guarantee
The accuracy of positioning, better than utilizing the TMS localization method of the progress of brain information in a certain respect merely before.
Claims (8)
1. a kind of visual cortex localization method of transcranial magnetic stimulation, which comprises the steps of:
S1, after amblyopia person's seat to be stimulated, make the head of person to be stimulated keep low level and being fixed with neck brace, and by shading eye
Cover and positioning cap are worn over person head to be stimulated, are held in position cap and are bonded with person head to be stimulated；
S2, by the handle of transcranial magnetic stimulation TMS coil upward, it is parallel with the linea vertebralis of person to be stimulated, will originate stimulus intensity MSO
Be set as 80%, above the occipital protuberance center line of person to be stimulated from 4CM single-frame move TMS coil up and down and seek
Look for vision hot spot；
S3, the corresponding position of the vision hot spot is fixed, turns down stimulus intensity, is sequentially stimulated from low to high with 2% gradient；
S4, judge whether person to be stimulated optical illusion occurs, if occurring, S5 is entered step, conversely, then return step S3；
Stimulus intensity when S5, record optical illusion probability of occurrence are more than or equal to 50%, and stimulus threshold is set by the stimulus intensity
Value PT；
S6, step S1-S5 is repeated after 24 hours, credit assigned is carried out to the stimulus threshold PT and is resurveyed；
S7, judge whether the Cronbach of the stimulus threshold PT after resurveying is more than or equal to 0.7, if so, completing visual cortex
Positioning, conversely, then return step S1.
2. the visual cortex localization method of transcranial magnetic stimulation according to claim 1, which is characterized in that needed before step S1 pair
The light that person to be stimulated carries out 40 minutes is deprived.
3. the visual cortex localization method of transcranial magnetic stimulation according to claim 1, which is characterized in that institute in the step S1
The overlay mark for stating positioning cap has nine grids, and guarantees occipital region mid-point in the nine sides center of a lattice face brain electric system.
4. the visual cortex localization method of transcranial magnetic stimulation according to claim 1, which is characterized in that in the step S2
TMS coil and person's skull surface to be stimulated are tangent, and do not contact the head of person to be stimulated.
5. the visual cortex localization method of transcranial magnetic stimulation according to claim 1, which is characterized in that sentence in the step S4
It is disconnected whether optical illusion occur method particularly includes:
Whether optical illusion is generated by the keyboard typing being connected on transcranial magnetic stimulation parameters console.
6. the visual cortex localization method of transcranial magnetic stimulation according to claim 1, which is characterized in that in the step S7 gram
The expression formula of the conspicuous coefficient a of rumba is as follows:
Wherein, k indicates the sum of measure the item,Indicate the variance of i-th result,Indicate the variance of overall measurement result.
7. a kind of visual cortex positioning device of transcranial magnetic stimulation, which is characterized in that including intensity correction TMS coil (3), positioning cap
(1), nine grids (2) being marked on the positioning cap, the transcranial magnetic stimulation ginseng being connect with the intensity correction TMS coil (3)
Number console (4), and the keyboard (5) being connect with the transcranial magnetic stimulation parameters console (4).
8. the positioning device of cranium Neural stem cell according to claim 7, which is characterized in that the positioning cap (1) is for being worn over
The head of person to be stimulated, for nine grids of label above it to be fixed；
The center of nine grid (2) is for occipital region mid-point in face brain electric system；
The intensity correction TMS coil (3) is used to find vision hot spot according to stimulus intensity；
The transcranial magnetic stimulation parameters console (4) is for adjusting stimulus intensity；
Whether the keyboard (5) observes the information of optical illusion for typing person to be stimulated.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910738600.0A CN110420389A (en) | 2019-08-12 | 2019-08-12 | A kind of the visual cortex localization method and device of transcranial magnetic stimulation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910738600.0A CN110420389A (en) | 2019-08-12 | 2019-08-12 | A kind of the visual cortex localization method and device of transcranial magnetic stimulation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN110420389A true CN110420389A (en) | 2019-11-08 |
Family
ID=68413904
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910738600.0A Pending CN110420389A (en) | 2019-08-12 | 2019-08-12 | A kind of the visual cortex localization method and device of transcranial magnetic stimulation |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN110420389A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111329446A (en) * | 2020-02-26 | 2020-06-26 | 四川大学华西医院 | Visual stimulation system and method for processing spatial frequency of facial pores through brain visual pathway |
| CN114053586A (en) * | 2021-11-15 | 2022-02-18 | 四川大学华西医院 | Positioning cap for transcranial magnetic therapy and other non-invasive treatments made by using transcranial brain atlas |
| CN114145758A (en) * | 2021-11-30 | 2022-03-08 | 深圳先进技术研究院 | Function detection system and method for subcutaneous access |
| WO2023066020A1 (en) * | 2021-10-19 | 2023-04-27 | 南京伟思医疗科技股份有限公司 | Therapeutic target automatic positioning method and system for transcranial magnetism, and helmet |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106075731A (en) * | 2016-03-02 | 2016-11-09 | 深圳英智科技有限公司 | Based on the dyskinetic method of transcranial magnetic stimulation treatment post-stroke |
| CN107497051A (en) * | 2017-09-25 | 2017-12-22 | 深圳市神经科学研究院 | A kind of trans-skull magnetic stimulating device and transcranial magnetic stimulation method of near infrared signal control |
| US20190082990A1 (en) * | 2017-09-19 | 2019-03-21 | Neuroenhancement Lab, LLC | Method and apparatus for neuroenhancement |
| CN109620222A (en) * | 2018-11-30 | 2019-04-16 | 广州市第人民医院（广州消化疾病中心、广州医科大学附属市人民医院、华南理工大学附属第二医院） | A kind of method for drafting of pharyngeal motor cortical area MEP topographic map |
-
2019
- 2019-08-12 CN CN201910738600.0A patent/CN110420389A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106075731A (en) * | 2016-03-02 | 2016-11-09 | 深圳英智科技有限公司 | Based on the dyskinetic method of transcranial magnetic stimulation treatment post-stroke |
| US20190082990A1 (en) * | 2017-09-19 | 2019-03-21 | Neuroenhancement Lab, LLC | Method and apparatus for neuroenhancement |
| CN107497051A (en) * | 2017-09-25 | 2017-12-22 | 深圳市神经科学研究院 | A kind of trans-skull magnetic stimulating device and transcranial magnetic stimulation method of near infrared signal control |
| CN109620222A (en) * | 2018-11-30 | 2019-04-16 | 广州市第人民医院（广州消化疾病中心、广州医科大学附属市人民医院、华南理工大学附属第二医院） | A kind of method for drafting of pharyngeal motor cortical area MEP topographic map |
Non-Patent Citations (2)
| Title |
|---|
| CHOI DEBLIECK ET AL.: "Correlation Between Motor and Phosphene Thresholds: A Transcranial Magnetic Stimulation Study", 《HUMAN BRAIN MAPPING》 * |
| FLORIAN HERPICH ET AL.: "Modulating the excitability of the visual cortex using a stimulation primingparadigm", 《NEUROPSYCHOLOGIA》 * |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111329446A (en) * | 2020-02-26 | 2020-06-26 | 四川大学华西医院 | Visual stimulation system and method for processing spatial frequency of facial pores through brain visual pathway |
| CN111329446B (en) * | 2020-02-26 | 2022-06-10 | 四川大学华西医院 | Visual stimulation system and method for processing spatial frequency of facial pores through brain visual pathway |
| WO2023066020A1 (en) * | 2021-10-19 | 2023-04-27 | 南京伟思医疗科技股份有限公司 | Therapeutic target automatic positioning method and system for transcranial magnetism, and helmet |
| CN114053586A (en) * | 2021-11-15 | 2022-02-18 | 四川大学华西医院 | Positioning cap for transcranial magnetic therapy and other non-invasive treatments made by using transcranial brain atlas |
| CN114145758A (en) * | 2021-11-30 | 2022-03-08 | 深圳先进技术研究院 | Function detection system and method for subcutaneous access |
| CN114145758B (en) * | 2021-11-30 | 2024-03-29 | 深圳先进技术研究院 | Function detection system and method for subcortical access |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN110420389A (en) | A kind of the visual cortex localization method and device of transcranial magnetic stimulation | |
| US11633595B2 (en) | System for variably configurable, adaptable electrode arrays and effectuating software | |
| CN113769275B (en) | Automatic positioning method and system for transcranial magnetic treatment target | |
| US20150174418A1 (en) | Device and Methods for Noninvasive Neuromodulation Using Targeted Transcranial Electrical Stimulation | |
| US20170296048A1 (en) | Smart eye system for Visuomotor dysfunction diagnosis and its operant conditioning | |
| Park et al. | Assessment of cognitive engagement in stroke patients from single-trial EEG during motor rehabilitation | |
| JP7100959B2 (en) | Systems and methods for non-invasive nerve stimulation | |
| Bao et al. | Cortico-muscular coherence modulated by high-definition transcranial direct current stimulation in people with chronic stroke | |
| CN111182835A (en) | Judgment of comfort and discomfort | |
| Fried et al. | Characterization of visual percepts evoked by noninvasive stimulation of the human posterior parietal cortex | |
| Pun et al. | Brain-computer interaction research at the Computer Vision and Multimedia Laboratory, University of Geneva | |
| US20140012152A1 (en) | Method of Decreasing Sensory Latency | |
| Xue et al. | Symptomatic responses elicited by electrical stimulation of the cingulate cortex: study of a cohort of epileptic patients and literature review | |
| CN107661199A (en) | A kind of eye eyesight restoration methods | |
| US20060052675A1 (en) | Method and system for the detection, amelioration and treatment of psychological trauma and other mental disorders, and for performance and creative enhancement | |
| Litvak | Analysis of the effects of transcranial magnetic stimulation on functional states and connectivity of the human cerebral cortex using electroencephalography | |
| Schjetnan et al. | Anodal transcranial direct current stimulation with monopolar pulses improves limb use after stroke by enhancing inter‑hemispheric coherence | |
| Mehrholz | Neurorehabilitation practice for stroke patients | |
| Anand et al. | Eye-tracker based test for assessing cognition | |
| CN114053586B (en) | Positioning cap for non-invasive treatment such as transcranial magnetic therapy by using transcranial brain atlas | |
| Sebastian et al. | Clinical Implementation of Noninvasive Brain Stimulation in an Outpatient Neurorehabilitation Program | |
| Kindred et al. | Interhemispheric asymmetries in intracortical facilitation correlate with fatigue severity in individuals with poststroke fatigue | |
| Bhagat et al. | A Study to Compare the Effect of Electromyography Biofeedback Versus Mime Therapy on Clinical and Electrophysiological Parameters in Subjects with Bell’s Palsy-A Comparative Interventional Study | |
| Chen et al. | Non-invasive eye acupuncture on visual accommodation | |
| Niu et al. | Xi'an, China |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20191108 |