CN110408192A - A kind of manganese carbonate/polyamino acid component and preparation method thereof - Google Patents
A kind of manganese carbonate/polyamino acid component and preparation method thereof Download PDFInfo
- Publication number
- CN110408192A CN110408192A CN201910572671.8A CN201910572671A CN110408192A CN 110408192 A CN110408192 A CN 110408192A CN 201910572671 A CN201910572671 A CN 201910572671A CN 110408192 A CN110408192 A CN 110408192A
- Authority
- CN
- China
- Prior art keywords
- manganese
- carbonate
- acid component
- polyamino acid
- polyaminoacid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K3/00—Use of inorganic substances as compounding ingredients
- C08K3/18—Oxygen-containing compounds, e.g. metal carbonyls
- C08K3/24—Acids; Salts thereof
- C08K3/26—Carbonates; Bicarbonates
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Inorganic Compounds Of Heavy Metals (AREA)
Abstract
The present invention discloses a kind of manganese carbonate/polyamino acid component and preparation method thereof, and method obtains manganese precursor solution comprising steps of A, mix by the aqueous solution of manganese salt or manganese salt, with Tris-HCl buffer；It is mixed by the aqueous solution of carbonate or carbonate, with Tris-HCl buffer, obtains carbonate precursor solution；B, by the aqueous solution of polyaminoacid or polyaminoacid, mixed with manganese precursor solution after, be added carbonate precursor solution in carry out standing reaction；Alternatively, by the aqueous solution of polyaminoacid or polyaminoacid, mixed with carbonate precursor solution after, be added manganese precursor solution in carry out standing reaction；C, it is separated by solid-liquid separation, washs, it is dry, obtain manganese carbonate/polyamino acid component.The preparation method of biomimetic mineralization of the invention is simple and convenient to operate, the equipment for not needing complex and expensive；Compound obtained has the drug release characteristics of good biocompatibility, biodegradability and pH response.
Description
Technical field
The present invention relates to biomaterial preparation technical field more particularly to a kind of manganese carbonate/polyamino acid component and its
Preparation method.
Background technique
Manganese ion is a kind of important magnetic resonance imaging contrast, while being also important one of the microelement of organism.
Therefore, such as manganese oxide, manganese carbonate of the material containing manganese are with a wide range of applications in biomedicine.Manganese carbonate is rung with pH
The dissolution characteristics answered, hydrolysate are manganese ion and carbon dioxide gas.The manganese ion for wherein hydrolyzing generation can be used for magnetic and be total to
Vibration imaging, and the carbon dioxide gas generated can then be excreted by human homergy, therefore use manganese carbonate conduct
The drug release characteristics of pH response not only may be implemented in pharmaceutical carrier, but also can also use magnetic resonance imaging monitoring therapeuticing effect.
Currently, manganese carbonate in biomedicine using relatively fewer, the main reason is that the synthesis of material is more difficult to control.
The manganese carbonate size of the preparations such as conventional synthetic method such as coprecipitation, hydro-thermal method is larger, is not suitable for being applied to nanosecond medical science neck
Domain.Although the available uniform particle sizes of pyrolysismethod, the lesser manganese carbonate nano particle of size, usually can in its preparation process
The substances such as a large amount of oleic acid/oleyl amines are added, this not only adds subsequent treatment process, but also can reduce the bio-safety of material
Property.
Therefore, the existing technology needs to be improved and developed.
Summary of the invention
In view of above-mentioned deficiencies of the prior art, the purpose of the present invention is to provide a kind of manganese carbonate/polyamino acid components
And preparation method thereof, it is intended to solve that manganese carbonate made from existing method is big there are size or purity is not high, it is difficult to meet biological doctor
The problem of learning application.
Technical scheme is as follows:
A kind of preparation method of manganese carbonate/polyamino acid component, wherein comprising steps of
A, it is mixed by the aqueous solution of manganese salt or manganese salt, with Tris-HCl buffer, obtains manganese precursor solution；By carbonate or carbon
The aqueous solution of hydrochlorate is mixed with Tris-HCl buffer, obtains carbonate precursor solution；
B, by the aqueous solution of polyaminoacid or polyaminoacid, mixed with manganese precursor solution after, be added carbonate precursor solution
In carry out standing reaction；
Alternatively, by the aqueous solution of polyaminoacid or polyaminoacid, mixed with carbonate precursor solution after, be added manganese presoma it is molten
Standing reaction is carried out in liquid；
C, it is separated by solid-liquid separation, washs, it is dry, obtain manganese carbonate/polyamino acid component.
Manganese carbonate/polyamino acid component preparation method, wherein in step A, the manganese salt is selected from MnCl2、
MnCl2·H2O、MnCl2·2H2O MnCl2·4H2O、Mn(NO3)2、Mn(NO3)2·4H2O、Mn(NO3)2·6H2O、Mn
(OAc)2、Mn(OAc)2·4H2O、Mn(OAc)2·2H2One of O or a variety of.
Manganese carbonate/polyamino acid component preparation method, wherein in step A, the carbonate is selected from
Na2CO3、Na2CO3·H2O、NaHCO3、K2CO3、KHCO3、(NH4)2CO3、(NH4)HCO3One of or it is a variety of.
Manganese carbonate/polyamino acid component preparation method, wherein in step B, the polyaminoacid is poly- second
Glycol-poly-aspartate.
Manganese carbonate/polyamino acid component preparation method, wherein the molecular weight of the polyethylene glycol is 1000
~ 10000, the degree of polymerization of the poly-aspartate is 10 ~ 100.
Manganese carbonate/polyamino acid component preparation method, wherein in step B, the manganese salt, carbonate
Molar ratio is 1~100:1, and the concentration of the polyaminoacid is 0.1~100mg/mL.
Manganese carbonate/polyamino acid component preparation method, wherein in step B, the condition for standing reaction
It is 4 ~ 37 DEG C, 0.5~48h.
A kind of manganese carbonate/polyamino acid component, wherein be prepared using as above any preparation method.
Manganese carbonate/the polyamino acid component, wherein the object Xiang Weifei of the manganese carbonate/polyamino acid component
Crystal phase, form are spherical shape.
The manganese carbonate/polyaminoacid composite Nano object, wherein the partial size of the manganese carbonate/polyamino acid component
For 10 ~ 500nm.
The utility model has the advantages that the present invention using manganese salt as manganese source, carbonate is carbonation source, Tris-HCl buffer is pH adjusting agent,
Polyaminoacid is template and stabilizer, prepares manganese carbonate/polyamino acid component by biomimetic mineralization.Polyaminoacid of the invention
It is environmental-friendly with good biocompatibility and degradability, toxic side effect will not be brought to the manganese carbonate of generation.The present invention
Preparation process be simple and convenient to operate, the equipment for not needing complex and expensive, it is easy to accomplish industrialized production.Preparation of the invention
Method has important scientific meaning and application value to the type and application range of extension manganese carbonate class biomaterial.The present invention
Manganese carbonate/polyamino acid component obtained has the drug of good biocompatibility, biodegradability and pH response
Release characteristics；Can be used for early diagnosis of cancer, drug delivery, protein adsorption, gene transfection, tissue repair, treatment of cancer and
Diagnosis and treatment integration etc. is expected to realize drug release monitoring and curative effect monitoring etc..
Detailed description of the invention
Fig. 1 is manganese carbonate/polyamino acid component XRD diagram made from the embodiment of the present invention 1.
Fig. 2 is the figure of manganese carbonate/polyamino acid component TEM made from embodiment 1.
Fig. 3 is manganese carbonate/polyamino acid component element Surface scan comparison diagram made from embodiment 1；Wherein, (a) is
TEM figure, (b-e) is respectively the Surface scan figure of element M n, C, O, N, (f) is full element surface scan figure.
Fig. 4 is manganese carbonate/polyamino acid component DLS grading curve made from embodiment 1.
Fig. 5 is the figure of manganese carbonate/polyamino acid component TEM made from embodiment 2.
Fig. 6 is the figure of manganese carbonate/polyamino acid component TEM made from embodiment 3.
Fig. 7 is the figure of manganese carbonate/polyamino acid component TEM made from embodiment 4.
Specific embodiment
The present invention provides a kind of manganese carbonate/polyamino acid component and preparation method thereof, to make the purpose of the present invention, technology
Scheme and effect are clearer, clear, and the present invention is described in more detail below.It should be appreciated that described herein specific
Embodiment is only used to explain the present invention, is not intended to limit the present invention.
The embodiment of the present invention provides a kind of preparation method of manganese carbonate/polyamino acid component, wherein comprising steps of
A, it is mixed by the aqueous solution of manganese salt or manganese salt, with Tris-HCl buffer, obtains manganese precursor solution；By carbonate or carbon
The aqueous solution of hydrochlorate is mixed with Tris-HCl buffer, obtains carbonate precursor solution；
B, by the aqueous solution of polyaminoacid or polyaminoacid, mixed with manganese precursor solution after, be added carbonate precursor solution
In carry out standing reaction；
Alternatively, by the aqueous solution of polyaminoacid or polyaminoacid, mixed with carbonate precursor solution after, be added manganese presoma it is molten
Standing reaction is carried out in liquid；
C, it is separated by solid-liquid separation, washs, it is dry, obtain manganese carbonate/polyamino acid component.
The present embodiment using manganese salt as manganese source, carbonate is carbonate source, Tris-HCl buffer is pH adjusting agent, poly- amino
Acid is template and stabilizer, prepares manganese carbonate/polyamino acid component by biomimetic mineralization.Tris-HCl in the present embodiment is slow
Fliud flushing is used to provide a stable neutrality or weakly alkaline environment for reaction system (because of under acid condition, such as when pH=6.5
Product will be degraded), it can be replaced by other pH adjusting agents, but phosphate buffered saline solution (phosphate buffer
Saline, PBS) except, because of PBS and Mn2+It reacts to form manganese phosphate precipitating.Polyaminoacid in this implementation has good
Biocompatibility and degradability, it is environmental-friendly, toxic side effect will not be brought to the manganese carbonate of generation.The preparation of the present embodiment
Simple process, easy to operate, the equipment for not needing complex and expensive, it is easy to accomplish industrialized production.The preparation method of the present embodiment
There is important scientific meaning and application value to the type and application range of extension manganese carbonate class biomaterial.
In one embodiment, in step A, the manganese salt may be selected from but not limited to MnCl2、MnCl2·H2O、
MnCl2·2H2O MnCl2·4H2O、Mn(NO3)2、Mn(NO3)2·4H2O、Mn(NO3)2·6H2O、Mn(OAc)2、Mn(OAc)2·
4H2O、Mn(OAc)2·2H2One of O or a variety of.Above-mentioned manganese salt is soluble manganese salt, can be directly dissolved in water, so that instead
It should can choose that source is wide, environment amenable water is as solvent.
In one embodiment, in step A, the carbonate may be selected from but not limited to Na2CO3、Na2CO3·H2O、
NaHCO3、K2CO3、KHCO3、(NH4)2CO3、(NH4)HCO3One of or it is a variety of.Above-mentioned carbonate is soluble carbonate salt,
It can be directly dissolved in water, source is wide so that reaction can choose, environment amenable water is as solvent.
In a preferred embodiment, in step B, the polyaminoacid is polyethylene glycol-polyaspartate.It is preferred that
Ground, for example 10000) for 1000 ~ 10000(, the degree of polymerization of the poly-aspartate is 10 ~ 100 to the molecular weight of the polyethylene glycol
(such as 50).The polyaminoacid specifically limited has good biocompatibility and degradability, environmental-friendly, will not be to life
At manganese carbonate bring toxic side effect.
In a preferred embodiment, in step B, the manganese salt, the molar ratio of carbonate are 1 ~ 100:1, described
The concentration of polyaminoacid is 0.1~100mg/mL.Wherein, the molar concentration of the manganese salt is 0.001~1mol/L, preferably
0.01~0.1mol/L.Above-mentioned material ratio, material concentration range are reacted, and all suitable carbonic acid of size and shape can be obtained
Manganese/polyamino acid component.Preferably, the manganese salt, the molar ratio of carbonate are 4~40:1；It is highly preferred that the manganese salt,
The molar ratio of carbonate is 10:1.Reacted within the scope of the material ratio, manganese carbonate obtained/polyamino acid component size compared with
More evenly, pattern is more regular for small, partial size, has great importance to application of the extension manganese carbonate in field of biomedicine.
In a preferred embodiment, in step B, the condition for standing reaction is 4 ~ 37 DEG C, 0.5~48h.On
It states and is reacted under reaction condition, all suitable manganese carbonate/polyamino acid component of size and shape can be obtained.
In a preferred embodiment, in step C, the mode of the separation of solid and liquid may be selected from but not limited to centrifugation point
From, filter and staticly settle separation one of；The solvent of the washing can be but be not limited to deionized water and/or anhydrous second
Alcohol；The mode of the drying can be but be not limited to be freeze-dried.
The embodiment of the present invention also provides a kind of manganese carbonate/polyamino acid component, wherein using as above any system
Preparation Method is prepared.
In one embodiment, the object of the manganese carbonate/polyamino acid component is mutually amorphous phase, and form is spherical shape.
In one embodiment, the partial size of the manganese carbonate/polyamino acid component is 10 ~ 500nm.
Manganese carbonate/the polyamino acid component of the present embodiment is of uniform size, morphological rules, has good bio-compatible
Property, biodegradability and pH response drug release characteristics；It can be used for early diagnosis of cancer, drug delivery, albumen to inhale
Attached, gene transfection, tissue repair, treatment of cancer and diagnosis and treatment integration etc. are expected to realize drug release monitoring and curative effect
Monitoring etc..
Below by specific embodiment, the present invention is described in detail.
Embodiment 1
(1) at room temperature, by 1.980g MnCl2•4H2O is dissolved in the MnCl for forming that concentration is 1mol/L in 10mL deionized water2It is molten
Liquid；By 1.060g Na2CO3It is dissolved in the Na for forming that concentration is 0.1mol/L in 100mL deionized water2CO3Solution.
(2) 0.1mL, the MnCl of 1mol/L are taken2Mixing in 0.9mL Tris-HCl buffer (10mmol/L) is added in solution
Uniformly, manganese precursor solution is obtained；The Na of 0.1mL, 0.1mol/L2CO3Solution and 0.8mL Tris-HCl buffer (10mmol/
L) it is mixed to form carbonate precursor solution.
(3) taking 0.1mL to contain 4mg polyethylene glycol-polyaspartate, (molecular weight of polyethylene glycol is 10000, poly- asparagus fern ammonia
After the degree of polymerization of acid mixes for aqueous solution 50) with above-mentioned carbonate precursor solution, it is added in above-mentioned manganese precursor solution, 4
DEG C refrigerator stands 12h.
(4) it is then centrifuged, and is washed with deionized 3 times, manganese carbonate/poly- amino is obtained using freeze-drying
Sour compound is powder sample.To manganese carbonate/polyamino acid component X-ray diffraction made from the embodiment
(diffraction of x-rays, XRD) test results are shown in figure 1, shows that sample obtained is amorphous phase；The implementation
Manganese carbonate/polyamino acid component transmission electron microscope (transmission electron microscope, TEM) made from example
Test results are shown in figure 2, shows that sample obtained is spherical structure, size is highly uniform；The test pair of its element Surface scan
Than result as shown in figure 3, showing that the elements such as manganese, carbon, oxygen, nitrogen are evenly distributed in manganese carbonate/polyamino acid component；Its dynamic
Light scatters (Dynamic Light Scattering, DLS) grading curve as shown in figure 4, the aquation diameter measured is
199nm shows that its average grain diameter is 199nm.
Embodiment 2
(1) at room temperature, by 1.980g MnCl2•4H2O is dissolved in the MnCl for forming that concentration is 1mol/L in 10mL deionized water2It is molten
Liquid；By 1.060g Na2CO3It is dissolved in the Na for forming that concentration is 0.1mol/L in 100mL deionized water2CO3Solution.
(2) 0.1mL, the MnCl of 1mol/L are taken2Mixing in 0.9mL Tris-HCl buffer (10mmol/L) is added in solution
Uniformly, manganese precursor solution is obtained；The Na of 0.1mL, 0.1mol/L2CO3Solution and 0.8mL Tris-HCl buffer (10mmol/
L) it is mixed to form carbonate precursor solution.
(3) taking 0.1mL to contain 8mg polyethylene glycol-polyaspartate, (molecular weight of polyethylene glycol is 10000, poly- asparagus fern ammonia
After the degree of polymerization of acid mixes for aqueous solution 50) with above-mentioned carbonate precursor solution, it is added in above-mentioned manganese precursor solution, 4
DEG C refrigerator stands 12h.
(4) it is then centrifuged, and is washed with deionized 3 times, manganese carbonate/poly- amino is obtained using freeze-drying
Sour compound is powder sample.Manganese carbonate/polyamino acid component TEM test result such as Fig. 5 institute made from the embodiment
Show, shows that sample obtained is spherical structure, size is highly uniform.
Embodiment 3
(1) at room temperature, by 1.980g MnCl2•4H2O is dissolved in the MnCl for forming that concentration is 1mol/L in 10mL deionized water2It is molten
Liquid；By 1.060g Na2CO3It is dissolved in the Na for forming that concentration is 0.1mol/L in 100mL deionized water2CO3Solution.
(2) 0.1mL, the MnCl of 1mol/L are taken2Mixing in 0.9mL Tris-HCl buffer (10mmol/L) is added in solution
Uniformly, manganese precursor solution is obtained；The Na of 0.1mL, 0.1mol/L2CO3Solution and 0.8mL Tris-HCl buffer (10mmol/
L) it is mixed to form carbonate precursor solution.
(3) taking 0.1mL to contain 4mg polyethylene glycol-polyaspartate, (molecular weight of polyethylene glycol is 10000, poly- asparagus fern ammonia
After the degree of polymerization of acid mixes for aqueous solution 50) with above-mentioned carbonate precursor solution, it is added in above-mentioned manganese precursor solution, 4
DEG C refrigerator stands 1h.
(4) it is then centrifuged, and is washed with deionized 3 times, manganese carbonate/poly- amino is obtained using freeze-drying
Sour compound is powder sample.Manganese carbonate/polyamino acid component TEM test result such as Fig. 6 institute made from the embodiment
Show, shows that sample obtained is spherical structure, size is highly uniform.
Embodiment 4
(1) at room temperature, by 1.980g MnCl2•4H2O is dissolved in the MnCl for forming that concentration is 1mol/L in 10mL deionized water2It is molten
Liquid；By 1.060g Na2CO3It is dissolved in the Na for forming that concentration is 0.1mol/L in 100mL deionized water2CO3Solution.
(2) 0.1mL, the MnCl of 1mol/L are taken2Mixing in 0.9mL Tris-HCl buffer (10mmol/L) is added in solution
Uniformly, manganese precursor solution is obtained；The Na of 0.1mL, 0.1mol/L2CO3Solution and 0.8mL Tris-HCl buffer (10mmol/
L) it is mixed to form carbonate precursor solution.
(3) taking 0.1mL to contain 4mg polyethylene glycol-polyaspartate, (molecular weight of polyethylene glycol is 10000, poly- asparagus fern ammonia
After the degree of polymerization of acid mixes for aqueous solution 50) with above-mentioned carbonate precursor solution, it is added in above-mentioned manganese precursor solution, 4
DEG C refrigerator is stood for 24 hours.
(4) it is then centrifuged, and is washed with deionized 3 times, manganese carbonate/poly- amino is obtained using freeze-drying
Sour compound is powder sample.Manganese carbonate/polyamino acid component TEM test result such as Fig. 7 institute made from the embodiment
Show, shows that sample obtained is spherical structure, size is highly uniform.
In conclusion the present invention using manganese salt as manganese source, carbonate is carbonate source, Tris-HCl buffer is that pH is adjusted
Agent, polyaminoacid are template and stabilizer, prepare manganese carbonate/polyamino acid component by biomimetic mineralization.It is poly- in the present invention
Amino acid has good biocompatibility and degradability, environmental-friendly, will not bring toxic side effect to the manganese carbonate of generation.
Preparation process of the invention is simple and convenient to operate, the equipment for not needing complex and expensive, it is easy to accomplish industrialized production.This implementation
The preparation method of example has important scientific meaning to the type and application range of extension manganese carbonate class biomaterial and applies valence
Value.Manganese carbonate/polyamino acid component produced by the present invention is of uniform size, morphological rules, has good biocompatibility, life
Biodegradable and the drug release characteristics of pH response；It can be used for early diagnosis of cancer, drug delivery, protein adsorption, gene
Transfection, tissue repair, treatment of cancer and diagnosis and treatment integration etc. are expected to realize drug release monitoring and curative effect monitoring etc..
It should be understood that the application of the present invention is not limited to the above for those of ordinary skills can
With improvement or transformation based on the above description, all these modifications and variations all should belong to the guarantor of appended claims of the present invention
Protect range.
Claims (10)
1. a kind of preparation method of manganese carbonate/polyamino acid component, which is characterized in that comprising steps of
A, it is mixed by the aqueous solution of manganese salt or manganese salt, with Tris-HCl buffer, obtains manganese precursor solution；By carbonate or carbon
The aqueous solution of hydrochlorate is mixed with Tris-HCl buffer, obtains carbonate precursor solution；
B, by the aqueous solution of polyaminoacid or polyaminoacid, mixed with manganese precursor solution after, be added carbonate precursor solution
In carry out standing reaction；
Alternatively, by the aqueous solution of polyaminoacid or polyaminoacid, mixed with carbonate precursor solution after, be added manganese presoma it is molten
Standing reaction is carried out in liquid；
C, it is separated by solid-liquid separation, washs, it is dry, obtain manganese carbonate/polyamino acid component.
2. the preparation method of manganese carbonate/polyamino acid component according to claim 1, which is characterized in that in step A,
The manganese salt is selected from MnCl2、MnCl2·H2O、MnCl2·2H2O MnCl2·4H2O、Mn(NO3)2、Mn(NO3)2·4H2O、Mn
(NO3)2·6H2O、Mn(OAc)2、Mn(OAc)2·4H2O、Mn(OAc)2·2H2One of O or a variety of.
3. the preparation method of manganese carbonate/polyamino acid component according to claim 1, which is characterized in that in step A,
The carbonate is selected from Na2CO3、Na2CO3·H2O、NaHCO3、K2CO3、KHCO3、(NH4)2CO3、(NH4)HCO3One of or
It is a variety of.
4. the preparation method of manganese carbonate/polyamino acid component according to claim 1, which is characterized in that in step B,
The polyaminoacid is polyethylene glycol-polyaspartate.
5. the preparation method of manganese carbonate/polyamino acid component according to claim 4, which is characterized in that the poly- second
The molecular weight of glycol is 1000 ~ 10000, and the degree of polymerization of the poly-aspartate is 10 ~ 100.
6. the preparation method of manganese carbonate/polyamino acid component according to claim 1, which is characterized in that in step B,
The manganese salt, the molar ratio of carbonate are 1~100:1, and the concentration of the polyaminoacid is 0.1~100mg/mL.
7. the preparation method of manganese carbonate/polyamino acid component according to claim 1, which is characterized in that in step B,
The condition for standing reaction is 4 ~ 37 DEG C, 0.5~48h.
8. a kind of manganese carbonate/polyamino acid component, which is characterized in that using the preparation side as described in claim 1 ~ 7 is any
Method is prepared.
9. manganese carbonate/polyamino acid component according to claim 8, which is characterized in that the manganese carbonate/polyaminoacid
The object of compound is mutually amorphous phase, and form is spherical shape.
10. manganese carbonate according to claim 8/polyaminoacid composite Nano object, which is characterized in that the manganese carbonate/poly-
The partial size of amino acid complex is 10 ~ 500nm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910572671.8A CN110408192B (en) | 2019-06-28 | 2019-06-28 | Manganese carbonate/polyamino acid compound and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910572671.8A CN110408192B (en) | 2019-06-28 | 2019-06-28 | Manganese carbonate/polyamino acid compound and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN110408192A true CN110408192A (en) | 2019-11-05 |
| CN110408192B CN110408192B (en) | 2021-11-23 |
Family
ID=68358387
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910572671.8A Active CN110408192B (en) | 2019-06-28 | 2019-06-28 | Manganese carbonate/polyamino acid compound and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN110408192B (en) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5534234A (en) * | 1994-11-14 | 1996-07-09 | Reddin; Lorin D. | Recovery of manganese from leach solutions |
| CN101269840A (en) * | 2008-03-05 | 2008-09-24 | 广州融捷材料科技有限公司 | Spherical manganese carbonate and preparing method thereof |
| CN104258423A (en) * | 2014-09-16 | 2015-01-07 | 首都医科大学 | Gadolinium-doped manganese carbonate dual-mode imaging probe for brain glioma |
-
2019
- 2019-06-28 CN CN201910572671.8A patent/CN110408192B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5534234A (en) * | 1994-11-14 | 1996-07-09 | Reddin; Lorin D. | Recovery of manganese from leach solutions |
| CN101269840A (en) * | 2008-03-05 | 2008-09-24 | 广州融捷材料科技有限公司 | Spherical manganese carbonate and preparing method thereof |
| CN104258423A (en) * | 2014-09-16 | 2015-01-07 | 首都医科大学 | Gadolinium-doped manganese carbonate dual-mode imaging probe for brain glioma |
Non-Patent Citations (2)
| Title |
|---|
| CHEN SHAO ET AL: "Multifunctional gadolinium-doped manganese carbonate nanoparticles for targeted MR/Fluorescence imaging of tiny brain gliomas", 《ANALYTICAL CHEMISTRY》 * |
| 周晚珠 等: "球形MnCO3粉的制备及其粒径控制", 《稀有金属与硬质合金》 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN110408192B (en) | 2021-11-23 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Zhou et al. | Mesoporous NaYbF4@ NaGdF4 core-shell up-conversion nanoparticles for targeted drug delivery and multimodal imaging | |
| Wilson Jr et al. | Surface modification of nanophase hydroxyapatite with chitosan | |
| Zhang et al. | Rod-shaped hydroxyapatite with mesoporous structure as drug carriers for proteins | |
| CN103467729B (en) | Polyethylene glycol-amino acid-polyester three-block polymkeric substance and its production and use | |
| CN101928458B (en) | Preparation method of multifunctional nanometer composite particle constructed by modified polymine | |
| CN103143043B (en) | Preparation method of Fe3O4/Au composite nanoparticles | |
| CN108295306B (en) | Three-dimensional printing hydrogel material containing mesoporous nano calcium phosphate particle filler and preparation method thereof | |
| Gao et al. | Polylysine coated bacterial cellulose nanofibers as novel templates for bone-like apatite deposition | |
| Sun et al. | Synthesis of surface modified Fe3O4 super paramagnetic nanoparticles for ultra sound examination and magnetic resonance imaging for cancer treatment | |
| CN106495225B (en) | A kind of polysaccharide hydridization manganese dioxide nano particle and its preparation method and purposes for magnetic resonance development | |
| CN112933251B (en) | Preparation method and application of mangano-manganic oxide nano-particles | |
| CN107519501A (en) | A kind of ferromagnetic nano material and preparation method and application | |
| CN113460986A (en) | Method for preparing core-shell structure hydroxyapatite microspheres by one-step method and application thereof | |
| CN104721841B (en) | A kind of fluorescence CT bimodal image probes and preparation method thereof | |
| Lv et al. | Surface modification of quantum dots and magnetic nanoparticles with PEG-conjugated chitosan derivatives for biological applications | |
| Fan et al. | The structural and surface properties of Al-doped hydroxyapatite (Ca5 (PO4) 3OH) nanorods and their applications for pH-induced drug delivery | |
| Yuan et al. | Synthesis, characterization and biological performance study of Sr-doped hydroxyapatite/chitosan composite coatings | |
| Wang et al. | Preparation and properties of soil conditioner microspheres based on self-assembled potassium alginate and chitosan | |
| CN1693415B (en) | Hydroxy phosphorite of near infrared fluorescence quantum point mark and its preparation process and application | |
| CN110104689A (en) | A kind of hollow manganese dioxide nano particle and preparation method thereof | |
| CN1709511A (en) | Drug-carrier calcium phosphate hano line and its preparing method | |
| CN110408192A (en) | A kind of manganese carbonate/polyamino acid component and preparation method thereof | |
| CN115520888B (en) | Application of carbon dioxide adduct of polyethyleneimine in preparation of calcium carbonate | |
| CN105902519B (en) | A kind of pH and glucose dual responsiveness pharmaceutical carrier and its preparation and application | |
| CN111097071B (en) | Porous material, casein calcium phosphorus microsphere and preparation method and application thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |