CN110404121A - Innovative method for performing surface modification on degradable support by using laser - Google Patents
Innovative method for performing surface modification on degradable support by using laser Download PDFInfo
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- CN110404121A CN110404121A CN201910569728.9A CN201910569728A CN110404121A CN 110404121 A CN110404121 A CN 110404121A CN 201910569728 A CN201910569728 A CN 201910569728A CN 110404121 A CN110404121 A CN 110404121A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/02—Inorganic materials
- A61L31/022—Metals or alloys
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/08—Materials for coatings
- A61L31/10—Macromolecular materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/148—Materials at least partially resorbable by the body
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- C—CHEMISTRY; METALLURGY
- C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
- C22F—CHANGING THE PHYSICAL STRUCTURE OF NON-FERROUS METALS AND NON-FERROUS ALLOYS
- C22F3/00—Changing the physical structure of non-ferrous metals or alloys by special physical methods, e.g. treatment with neutrons
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/18—Modification of implant surfaces in order to improve biocompatibility, cell growth, fixation of biomolecules, e.g. plasma treatment
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- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
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- Heart & Thoracic Surgery (AREA)
- Surgery (AREA)
- Vascular Medicine (AREA)
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- Organic Chemistry (AREA)
- Metallurgy (AREA)
- Crystallography & Structural Chemistry (AREA)
- Mechanical Engineering (AREA)
- Inorganic Chemistry (AREA)
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Abstract
The invention discloses an innovative method for modifying the surface of a degradable support by using laser, which comprises the following steps: step S1, processing the surface of the bracket material according to a preset contour by using first laser equipment, and forming a plurality of micro-pit structures on the surface of the material; step S2, processing the surface of the bracket material according to a preset contour by using second laser equipment, and forming a highly cross-linked reticular structure on the surface of the material to obtain a material to be processed; step S3, coating the inner surface of the material to be treated by utilizing the adhesive protein to form an artificial endothelial cell lower matrix layer; the scaffold material is a magnesium alloy material and is used for manufacturing the degradable scaffold.
Description
Technical field
The present invention relates to technical field of biological materials more particularly to a kind of to utilize laser to carry out biodegradable stent surface modified
Inventive process.
Background technique
With stepping up for medical level, insertion type bracket rebuilds blood fortune and has become clinical treatment cardiovascular and cerebrovascular disease
The important means of disease.For at present, bracket can be divided into traditional permanent metal bracket and novel Biodegradable scaffold.
Patient uses traditional permanent metal bracket, generally requires the formation for taking the pre- preventing thrombosis of antiplatelet drug for a long time, however
Bracket cannot degrade after completing supporting role, and long-time stimulus pulls vascular wall, gradually cause in-stent restenosis.Therefore it grinds
The person of studying carefully proposes Biodegradable scaffold, voluntarily gradually drops after bracket provides the mechanical support of a period of time as needed
The problem of solution, thus there is no long-time stimulus vascular walls, the risk of in-stent restenosis can be reduced, improve controlling for bracket
Therapeutic effect.For at present, biodegradable stent is divided into degradable polymer bracket, degradable ferroalloy bracket and degradable magnesium alloy
Bracket.Wherein, the mechanical support power that polymer support provides is limited, and ferroalloy bracket is too slow in the degradation rate of organism, because
This degradable magnesium alloy bracket becomes research hotspot.
Research thinks that target vessel needs reconstruction in 6-12 months to repair the phase after Stent Implantation, therefore bracket should be fine
Reliable mechanical support is provided during this section, need to enter the fast degradation phase after this, and can be at 12-24 months
It is interior degradable.After stenter to implant blood vessel, the proliferation and migration of vascular endothelial cell and vascular smooth muscle cells are conducive to as early as possible
Exposed bracket is covered, bracket endothelialization process is completed.For current degradable magnesium alloy, the Mg that is discharged in degradation process2+
Property nontoxic to the human body, therefore magnesium alloy bracket has good biocompatibility and biodegradability.However, the study found that
Since the chemical property of magnesium is active, so that magnesium alloy bracket degradation in vivo rate is too fast, begin to lose bracket within general 5-8 weeks
Mechanical integrity, and not enough, there is no complete bracket for vascular endothelial cell and vascular smooth muscle cell proliferation amount at this time
Endothelialization process influences bracket using effect.
The information disclosed in the background technology section is intended only to deepen understanding of the general background technology to the present invention, and
It is not construed as recognizing or implying in any form that the information constitutes the prior art known to those skilled in the art.
This is solved the problems, such as reply, and the applicant is quasi- to carry out surface modification to magnesium alloy bracket with laser, increases in body
Biomolecule (especially vascular endothelial cell and vascular smooth muscle cells) the inner surface of magnesium alloy bracket aggregation and attachment,
So that the more endothelial cells of magnesium alloy bracket inner surface attachment, the endothelialization process of quickening bracket in the blood vessels, and this
Magnesium alloy bracket still can voluntarily degrade in vivo afterwards, so as to provide more effective effect for target vessel.
For these reasons, the modified novelty in biodegradable stent surface is carried out using laser present applicant has proposed a kind of
Method, it is intended to the endothelialization process for accelerating degradable magnesium alloy bracket at this stage, so that degradable magnesium alloy bracket both may be used
To provide reliable mechanical support power well at the appointed time for blood vessel, can also after this in vivo well voluntarily
Degradation, can provide more effective effect for target vessel.
Summary of the invention
In order to meet above-mentioned requirements, changed the purpose of the present invention is to provide a kind of using laser progress biodegradable stent surface
The inventive process of property.
To achieve the goals above, the invention adopts the following technical scheme:
It is a kind of to carry out the modified inventive process in biodegradable stent surface using laser, comprising the following steps:
Step S1 is formed timbering material surface according to default contour machining using first laser equipment on the surface of the material
Several miniature bowl configurations in place；
Step S2 is formed timbering material surface according to default contour machining using second laser equipment on the surface of the material
Highly cross-linked reticular structure obtains material to be processed；
Step S3 is wrapped up using inner surface of the attachment proteins to material to be processed, is formed under artificial endothelial cell
Hypothallus；
Wherein, the timbering material is magnesium alloy materials, for manufacturing biodegradable stent.
Further technical solution is that the step S1 further includes that the first laser equipment is that pulsewidth is less than 2ps, wave band
Reach 5um in the size of the ultrafast laser of 1030-1064mm, the ultrafast laser focal beam spot.
Further technical solution is that the step S1 further includes that the length of the bowl configurations is 25-50um, and width is
10-15um, depth 0.3-0.7um.
Further technical solution is that the step S2 further includes that the second laser equipment is that pulsewidth is less than 800fs, wave
For section in the ultrafast laser of 515-1030nm, the size of the ultrafast laser focal beam spot reaches 3um.
Further technical solution is that the step S2 further includes that longitudinally adjacent of the reticular structure is divided into 25-50um,
Laterally adjacent is divided into 10-15um, depth 0.3-0.7um.
Further technical solution is that the attachment proteins include gelatin, fibronectin, collagen.
Compared with the prior art, the beneficial effects of the present invention are: laser and substrate surface interaction by way of,
The modification of substrate surface may be implemented, to accelerate magnesium alloy in the intracorporal endothelialization process of machine, so that degradable magnesium closes
Golden bracket both can provide reliable mechanical support power well at the appointed time for blood vessel, can also after this in vivo
It voluntarily degrades well, is a kind of surface modifying method of very potential innovative biodegradable stent.Specific effect is as follows:
1. laser directly acts on magnesium alloy substrates, its surface is modified, strong operability, the shape of surface micro-structure
Looks and position can be adjusted according to specific requirement；And according to the characteristic of material itself can there are many can choose
Light source, use scope are extensive；
2. generate specific surface micro-structure on the surface of the material by the interaction of laser and material, according to specifically may be used
The endothelialization rate selection of degradation magnesium alloy in vivo is formed by structure, so that degradable magnesium alloy reaches expected effect
Fruit；
3. carrying out surface to material by laser to be modified, reduce in traditional method of modifying through coating to material carry out table
Whether the unstable factor during face is modified, such as the decomposition of conventional coatings can generate to the harmful substance of body, coating and substrate
Adherency it is whether secured the problems such as；
To sum up, it carries out surface to degradable magnesium alloy bracket by laser to be modified, strong operability and stable structure can
The modification for realizing substrate surface well accelerates magnesium alloy in the intracorporal endothelialization process of machine, so that degradable magnesium alloy
Bracket both can provide reliable mechanical support power well at the appointed time for blood vessel, after this degradable magnesium alloy branch
Frame is voluntarily degraded well in vivo.
The invention will be further described in the following with reference to the drawings and specific embodiments.
Detailed description of the invention
Fig. 1 is a kind of specific embodiment that the modified inventive process in biodegradable stent surface is carried out using laser of the present invention
Flow chart.
Specific embodiment
In order to make the objectives, technical solutions, and advantages of the present invention clearer, with reference to the accompanying drawing and specific implementation
Invention is further described in detail for mode.
Following will be combined with the drawings in the embodiments of the present invention, and technical solution in the embodiment of the present invention carries out clear, complete
Site preparation description, it is clear that described embodiments are only a part of the embodiments of the present invention, instead of all the embodiments.It is based on
Embodiment in the present invention, those skilled in the art's every other implementation obtained without creative efforts
Example, shall fall within the protection scope of the present invention.
In the description of the present invention, it is to be understood that, term " center ", " longitudinal direction ", " transverse direction ", " length ", " width ",
" thickness ", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom" "inner", "outside", " up time
The orientation or positional relationship of the instructions such as needle ", " counterclockwise " is to be based on the orientation or positional relationship shown in the drawings, and is merely for convenience of
The description present invention and simplified description, rather than the device or element of indication or suggestion meaning must have a particular orientation, with spy
Fixed orientation construction and operation, therefore be not considered as limiting the invention.
In addition, term " first ", " second " are used for descriptive purposes only and cannot be understood as indicating or suggesting relative importance
Or implicitly indicate the quantity of indicated technical characteristic.Define " first " as a result, the feature of " second " can be expressed or
Implicitly include one or more of the features.In the description of the present invention, the meaning of " plurality " is two or more,
Unless otherwise specifically defined.
In the present invention unless specifically defined or limited otherwise, term " installation ", " connected ", " connection ", " fixation " etc.
Term shall be understood in a broad sense, for example, it may be connection, may be a detachable connection, or integral；It can be mechanical connection,
It is also possible to be electrically connected；It can be directly connected, can also can be inside two elements indirectly connected through an intermediary
The interaction relationship of connection or two elements.For the ordinary skill in the art, it can manage as the case may be
Solve the concrete meaning of above-mentioned term in the present invention.
In the present invention unless specifically defined or limited otherwise, fisrt feature second feature "upper" or "lower"
It may include that the first and second features directly contact, also may include that the first and second features are not direct contacts but pass through it
Between other characterisation contact.Moreover, fisrt feature includes the first spy above the second feature " above ", " above " and " above "
Sign is right above second feature and oblique upper, or is merely representative of first feature horizontal height higher than second feature.Fisrt feature exists
Second feature " under ", " lower section " and " following " include that fisrt feature is directly below and diagonally below the second feature, or is merely representative of
First feature horizontal height is less than second feature.
In the description of this specification, reference term " one embodiment ", " some embodiments ", " example ", " specifically show
The description of example " or " some examples " etc. means specific features, structure, material or spy described in conjunction with this embodiment or example
Point is included at least one embodiment or example of the invention.In the present specification, schematic expression of the above terms are not
It is interpreted as that identical embodiment or example must be directed to.Moreover, particular features, structures, materials, or characteristics described
It can be combined in any suitable manner in any one or more of the embodiments or examples.In addition, those skilled in the art can
Different embodiments or examples described in this specification are engaged and be combined.
Method flow diagram as shown in Figure 1 carries out the modified wound in biodegradable stent surface using laser for the present invention is a kind of
The specific embodiment flow chart of new property method, comprising the following steps:
Step S1 is formed timbering material surface according to default contour machining using first laser equipment on the surface of the material
Several miniature bowl configurations in place；
Step S2 is formed timbering material surface according to default contour machining using second laser equipment on the surface of the material
Highly cross-linked reticular structure obtains material to be processed；
Step S3 is wrapped up using inner surface of the attachment proteins to material to be processed, is formed under artificial endothelial cell
Hypothallus；
Wherein, the timbering material is magnesium alloy materials, for manufacturing biodegradable stent.
Specifically, for degradable magnesium alloy bracket, there is the mode for using surface to coat to accelerate magnesium alloy in body at present
Interior endothelialization process, such as material surface coat the coating containing endothelial growth factor.However it is this on the surface of the material
There is also limitations, such as selectable coating to need good biocompatibility and nontoxicity for the mode of progress coating, and
Coating can not be discharged in degradation process to the harmful substance of body, at the same can not influence bracket itself mechanical performance and
Later degradability；But this is only by the simple physical absorption of coating in substrate surface, the stability of coating compared with
Difference can fall off from substrate surface.Therefore, for these requirements, it can be used and directly timbering material progress surface micro-structure is modified,
Both other, which will not have been introduced, may influence the foreign substance of rack mechanical performance, also reduce other coating bring bio-toxicities
Potential threat.
In addition, to prevent platelet adhesion reaction, in-stent restenosis, having at present using table for degradable magnesium alloy bracket
The mode of finishing coat is to reduce blood platelet in the attachment of rack surface, such as coating much has 2- metering system on the surface of the material
The copolymer of trimethylammonium Phosphorylcholine, can be passivated sensitive magnesium alloy materials surface in this way, i.e. blood will not directly connect
Material surface is touched, biomolecule can be effectively reduced in the attachment of rack surface.However if by the simple physics of coating
It is adsorbed on substrate surface, the stability of coating can be poor, can be easy to fall off from substrate surface, thus ineffective.Therefore, for
These requirements can be used and directly be modified to timbering material progress surface micro-structure, and will not both introduce other may influence timbering machine
The foreign substance of tool performance also reduces the potential threat of other coating bring bio-toxicities.
In step S2 and S3, in order to meet above-mentioned requirements, it is modified that surface micro-structure is carried out to timbering material using laser.
Since vascular endothelial cell is very thin, thickness is about 0.1-1um, and shuttle is presented in length about 25-50um, width about 10-15um in vivo
Shape, so, in most cases the surface area of material is bigger, the surface the coarse more is conducive to the aggregation of biomolecule and attached
, then in this step, can be formed on the surface of the material using laser highly cross-linked according to the interaction of laser and material
Reticular structure, compared to untreated material surface, highly cross-linked reticular structure can make biomolecule more easily attached
On the surface of the material.Then processed material inner surface is wrapped with the attachment proteins such as gelatin or fibronectin or collagen again
It wraps up in, forms hypothallus under artificial endothelial cell, the adherency and growth of endothelial cell can be promoted.
In embodiment as shown in Figure 1, by step S1 the step of handled obtained material, compared to without place
The material surface of reason, since vascular endothelial cell is very thin, thickness is about 0.1-1um, length about 25-50um, width about 10-
15um, is presented shuttle shape in vivo, and bowl configurations can make biomolecule be easier to adhere on the surface of the material.For magnesium alloy itself
Belong to temperature sensitive material, therefore selected light source should both can satisfy the threshold value of material effects, it can not be to material sheet
The function of body change it is too big, such as phenomena such as melt.Therefore, the step S1 further includes that the first laser equipment is
Pulsewidth is less than 2ps, wave band in the ultrafast laser of 1030- 1064mm, and the size of the ultrafast laser focal beam spot reaches
3um is modified Mg alloy surface, by different laser processing modes, processes pit on the surface of magnesium alloy materials
Structure.
In other embodiments, the step S1 can be according to the characteristic of material itself can there are many light that can choose
Source, the ultrafast laser in this method is not only as an example, indicate or imply that first laser equipment is only in the step S1 of this method
Only it is defined in ultrafast laser.
Preferably, the step S1 further includes the length of the bowl configurations about 25-50um, width 10-15um, deep
Degree is 0.3-0.7um.Bowl configurations make biomolecule more easily assemble and adhere on the surface of the material, to accelerate endothelial cell
Proliferation, accelerate magnesium alloy in the intracorporal endothelialization process of machine, so as to provide more effective effect for target vessel.
In embodiment as shown in Figure 1, for magnesium alloy, itself belong to temperature sensitive material, therefore selected
Light source should both can satisfy the threshold values of material effects, the function of material itself can not be changed too big, such as melted
Phenomena such as melting.In the present embodiment, the step S2 further includes that the second laser equipment is that pulsewidth is less than 800fs, wave band exists
The size of the ultrafast laser of 515- 1030nm, the ultrafast laser focal beam spot reaches 3um, to Mg alloy surface into
Row is modified, and by different laser processing modes, highly cross-linked reticular structure is processed on the surface of magnesium alloy materials.
In other embodiments, the step S2 can be according to the characteristic of material itself can there are many light that can choose
Source, the ultrafast laser in this method is not only as an example, indicate or imply that second laser equipment is only in the step S2 of this method
Only it is defined in ultrafast laser.
Preferably, the step S2 further includes, and longitudinally adjacent of the reticular structure is divided into 25- 50um, and laterally adjacent
Every about 10-15um, depth 0.3-0.7um.Highly cross-linked reticular structure gathers biomolecule more easily on the surface of the material
Collection and attachment accelerate magnesium alloy in the intracorporal endothelialization process of machine, so as to be target blood to accelerate the proliferation of endothelial cell
Pipe provides more effectively effect.
In embodiment as shown in Figure 1, the attachment proteins include gelatin, fibronectin, collagen.
Using the surface modifying method of this programme, the endothelialization process of degradable magnesium alloy bracket at this stage can be accelerated,
So that degradable magnesium alloy bracket both can provide reliable mechanical support power well at the appointed time for blood vessel,
It can voluntarily degrade well in vivo after this.Since the chemical property of magnesium is active, so that magnesium alloy bracket drops in vivo
It is too fast to solve rate, the general 5-8 weeks mechanical integrity for beginning to lose bracket, and vascular endothelial cell and vascular smooth muscle at this time
Not enough, there is no the endothelialization processes for completing bracket for cell Proliferation amount, influence bracket using effect.
It is modified using laser equipment surface to be carried out to magnesium alloy bracket in this method, create several bowl configurations and
Reticular structure is wrapped up using inner surface of the attachment proteins to material to be processed, forms hypothallus under artificial endothelial cell,
The adherency and growth for promoting endothelial cell, can increase biomolecule in body (especially vascular endothelial cell and vascular smooth
Myocyte) magnesium alloy bracket inner surface aggregation and attachment so that in the attachment of magnesium alloy bracket inner surface is more
Chrotoplast accelerates the endothelialization process of bracket in the blood vessels, and hereafter magnesium alloy bracket still can voluntarily be dropped in vivo
Solution, so as to provide more effective effect for target vessel.
In conclusion using the surface modifying method of this programme, it, can by way of laser and substrate surface interaction
To realize the modification of substrate surface, to accelerate magnesium alloy in the intracorporal endothelialization process of machine, so that degradable magnesium alloy
Bracket both can provide reliable mechanical support power well at the appointed time for blood vessel, can also after this in vivo very
Good voluntarily degradation is a kind of surface modifying method of very potential innovative biodegradable stent.Specific effect is as follows:
1. laser directly acts on magnesium alloy substrates, its surface is modified, strong operability, the shape of surface micro-structure
Looks and position can be adjusted according to specific requirement；And according to the characteristic of material itself can there are many can choose
Light source, use scope are extensive；
2. generate specific surface micro-structure on the surface of the material by the interaction of laser and material, according to specifically may be used
The endothelialization rate selection of degradation magnesium alloy in vivo is formed by structure, so that degradable magnesium alloy reaches expected effect
Fruit；
3. carrying out surface to material by laser to be modified, reduce in traditional method of modifying through coating to material carry out table
Whether the unstable factor during face is modified, such as the decomposition of conventional coatings can generate to the harmful substance of body, coating and substrate
Adherency it is whether secured the problems such as；
To sum up, it carries out surface to degradable magnesium alloy bracket by laser to be modified, strong operability and stable structure can
The modification for realizing substrate surface well accelerates magnesium alloy in the intracorporal endothelialization process of machine, so that degradable magnesium alloy
Bracket both can provide reliable mechanical support power well at the appointed time for blood vessel, after this degradable magnesium alloy branch
Frame is voluntarily degraded well in vivo.
It will be apparent to those skilled in the art that it is various that other can be made according to the above description of the technical scheme and ideas
It is corresponding to change and deformation, and all these change and deformation should belong to the claims in the present invention protection scope it
It is interior.
Claims (6)
1. a kind of carry out the modified inventive process in biodegradable stent surface using laser, which comprises the following steps:
Step S1 is formed several on the surface of the material using first laser equipment to timbering material surface according to default contour machining
Locate miniature bowl configurations；
Step S2 forms height using second laser equipment to timbering material surface according to default contour machining on the surface of the material
The reticular structure of crosslinking obtains material to be processed；
Step S3 is wrapped up using inner surface of the attachment proteins to material to be processed, forms matrix under artificial endothelial cell
Layer；
Wherein, the timbering material is magnesium alloy materials, for manufacturing biodegradable stent.
2. a kind of inventive process modified using laser progress biodegradable stent surface according to claim 1, special
Sign is that the step S1 further includes that the first laser equipment is that pulsewidth is less than 2ps, wave band in the ultrafast of 1030-1064mm
The size of laser, the ultrafast laser focal beam spot reaches 5um.
3. a kind of inventive process modified using laser progress biodegradable stent surface according to claim 1, special
Sign is that the step S1 further includes that the length of the bowl configurations is 25-50um, width 10-15um, depth 0.3-
0.7um。
4. a kind of inventive process modified using laser progress biodegradable stent surface according to claim 1, special
Sign is that the step S2 further includes that the second laser equipment is that pulsewidth is less than 800fs, wave band in the super of 515-1030nm
The size of fast laser, the ultrafast laser focal beam spot reaches 3um.
5. a kind of inventive process modified using laser progress biodegradable stent surface according to claim 1, special
Sign is that the step S2 further includes that longitudinally adjacent of the reticular structure is divided into 25-50um, and laterally adjacent is divided into 10-
15um, depth 0.3-0.7um.
6. a kind of inventive process modified using laser progress biodegradable stent surface according to claim 1, special
Sign is that the attachment proteins include gelatin, fibronectin, collagen.
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| CN112617949A (en) * | 2020-12-31 | 2021-04-09 | 微创神通医疗科技（上海）有限公司 | Spring ring and preparation method thereof |
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