CN110402921A - A kind of room temperature oxygen carrying device for casting of in vitro animal's liver - Google Patents
A kind of room temperature oxygen carrying device for casting of in vitro animal's liver Download PDFInfo
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- CN110402921A CN110402921A CN201910841432.8A CN201910841432A CN110402921A CN 110402921 A CN110402921 A CN 110402921A CN 201910841432 A CN201910841432 A CN 201910841432A CN 110402921 A CN110402921 A CN 110402921A
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
- A01N1/0236—Mechanical aspects
- A01N1/0242—Apparatuses, i.e. devices used in the process of preservation of living parts, such as pumps, refrigeration devices or any other devices featuring moving parts and/or temperature controlling components
- A01N1/0247—Apparatuses, i.e. devices used in the process of preservation of living parts, such as pumps, refrigeration devices or any other devices featuring moving parts and/or temperature controlling components for perfusion, i.e. for circulating fluid through organs, blood vessels or other living parts
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Abstract
The invention discloses a kind of room temperature oxygen carrying device for casting of in vitro animal's liver, including main body, working chamber is offered in the main body, storage box is equipped in the working chamber, the openable emulation chamber in front side is equipped in the storage box, the emulation is intracavitary to store delivery pipe liver, intracavitary be equipped with of the emulation can support the delivery pipe liver, and the delivery pipe liver can be made uprightly to store to promote the supporting mechanism of fidelity, drive cavity is offered on the downside of the working chamber, the swaying mechanism that can control the storage box to be circumferentially centrifuged rotation to prevent the emulation intracavity blood from condensing is equipped in the drive cavity, the present invention can pass through room temperature oxygen carrying perfusion technique, save the available long-time of in vitro animal's liver, the research to Liver Allograft Preservation technology can be further strengthened.
Description
Technical field
The present invention relates in vitro liver Techniques of preserving field, dress is perfused in the room temperature oxygen carrying of specially a kind of in vitro animal's liver
It sets.
Background technique
Currently, be always the big problem that could not improve solution for the store method of in vitro liver, in order to guarantee from
Body liver can be saved under the premise of not losing activity, and primarily solve the problems, such as to be exactly the environment in artificial animal body,
It just can increase the survival rate of liver in this way, and room temperature oxygen carrying perfusion technique, it is a kind of one of the method for Liver Allograft Preservation, on the market very
Rare this equipment, existing equipment is also it is difficult to ensure that complete fidelity, firstly, not can guarantee the placement status of liver,
It is secondary, usually all it is static placement, in addition, the blood circulation in device is only merely standard machinery circulation, does not simulate animal body
Interior blood operation state.
Summary of the invention
The purpose of the present invention is to provide a kind of room temperature oxygen carrying device for casting of in vitro animal's liver, for overcoming existing skill
Drawbacks described above in art.
A kind of room temperature oxygen carrying device for casting of in vitro animal's liver of embodiment according to the present invention, including main body, institute
It states and offers working chamber in main body, storage box is equipped in the working chamber, it is openable imitative that front side is equipped in the storage box
True chamber, the emulation is intracavitary to store delivery pipe liver, and intracavitary be equipped with of the emulation can support the delivery pipe liver, and can make
The delivery pipe liver is uprightly stored to promote the supporting mechanism of fidelity, and drive cavity, institute are offered on the downside of the working chamber
Stating to be equipped in drive cavity can control the storage box to be centrifuged rotation circumferentially to prevent rocking for the emulation intracavity blood condensation
Mechanism offers rectangular cavity on the upside of the working chamber, is connected between the working chamber and the rectangular cavity and is equipped with pressing chamber, institute
Stating interior be equipped with of rectangular cavity can be to the bags of blood of the emulation chamber blood perfusion, and the bags of blood is interior equipped with blood chamber, the blood
It is connected between chamber and the emulation chamber and hose is installed, the summit portion that the hose is located at the storage box is fixedly installed with resistance
Buddhist nun's valve offers power cavity on the left of the rectangular cavity, and being equipped in the power cavity can control the bags of blood to rock back and forth to come
The swing mechanism of blood clotting in the blood chamber is prevented, the pressing is intracavitary to be equipped with briquetting, opens on the downside of the power cavity
It is described driven intracavitary equipped with the pulse mechanism that can control the briquetting intermittence to squeeze the hose equipped with driven chamber, it is described
Pulse mechanism can make the blood in the blood chamber enter intracavitary, the rectangular cavity of the emulation in the form of exemplary pulse effect
Right side opening be equipped with and fill oxygen chamber, offer storage chamber on the downside of the filling oxygen chamber, be installed with centrifugal pump on the storage chamber bottom wall,
The centrifugal pump can be delivered to the emulation intracavitary blood that the fillings oxygen is intracavitary, to guarantee described to emulate intracavitary blood and follow
Ring, intracavitary be equipped with of the filling oxygen can be filled with oxygen to increase the Guan Yang mechanism of blood oxygen levels.
In addition, in one embodiment, the supporting mechanism includes two groups of support plates, card is equipped in the support plate
Slot is installed with cushion on the inner wall of the card slot, is installed with hinge bar in the left wall of the emulation chamber, is located at the left side branch
The bottom surface of fagging and the right side of the driven chamber are hinged, and the right side positioned at the right side support plate is installed with mobile bar, institute
Stating mobile bar, the inner wall of the storage box is run through in extension to the right, and protrudes into the working chamber, and the right side of the mobile bar
Side is installed with manual disk, is fixedly installed with sealing shroud, the movement on the mobile bar periphery intracavitary positioned at the emulation
The inner wall of bar and the storage box is slidably matched, the delivery pipe liver can inlay card in two card slots.
In addition, in one embodiment, the swaying mechanism includes the first motor being installed on the drive cavity bottom wall,
The left and right sides of the first motor is connected by power equipped with horizontal axis, and the another side of the horizontal axis is installed with the first cone tooth
Wheel, the left and right sides of the working chamber offers gear cavity, turns in the inner wall between the gear cavity and the drive cavity
Dynamic to be equipped with vertical pivot, the vertical pivot downward extension portion protrudes into the drive cavity, and the bottom surface of the vertical pivot is installed with second
Bevel gear, the second bevel gear are engaged with the first bevel gear, and the vertical pivot upwardly extends part and protrudes into the gear
It is intracavitary, and the top surface of the vertical pivot is installed with third hand tap gear, rotates and is equipped in the gear cavity and the inner wall of the working chamber
Short axle, the short axle to the left protrude into the gear cavity by extension, and the left side of the short axle is installed with the 4th bevel gear,
4th bevel gear engages with the third hand tap gear, and the short axle to the right protrude into the working chamber by extension, and
The another side of the short axle is installed with link block, and two link block sides close to each other are installed with support shaft, and two
A support shaft is fixedly connected with the storage box.
In addition, in one embodiment, the swing mechanism includes the second motor being installed in the power cavity left wall,
The right side power of second motor is connected with driving shaft, and the right side of the driving shaft is installed with turntable, the bags of blood
Top surface be installed with bracket, rotation is equipped with connecting rod, the connecting rod in the inner wall between the rectangular cavity and the power cavity
Extension is protruded into the rectangular cavity to the right, and is fixedly connected with the bracket, and the connecting rod to the left protrude by extension
In the power cavity, and the left side of the connecting rod is installed with turntable, is hingedly equipped between the turntable and the driving shaft
The radius of connecting rod, the turntable is much larger than the turntable.
In addition, in one embodiment, the pulse mechanism include rotation be located at the power cavity and the driven chamber it
Between driven shaft in inner wall, the driven shaft, which upwardly extends, to be partially protruded into the power cavity, and the top surface of the driven shaft is solid
Equipped with the 5th bevel gear, the 6th bevel gear, the 6th bevel gear and the 5th cone are installed on the periphery of the driving shaft
Gear engagement, the driven shaft downward extension portion protrude into described driven intracavitary, and the bottom surface of the driven shaft is installed with runner,
Connection is equipped with sliding cavity between the driven chamber and the pressing chamber, and sliding is equipped with cross bar on the bottom wall of the sliding cavity, described
Cross bar to the left protrude into described driven intracavitary and hinged with the runner by extension, and institute is protruded into extension to the cross bar to the right
State pressing it is intracavitary, it is described pressing chamber left side be fixedly connected with the right side of the cross bar.
In addition, in one embodiment, be connected between the emulation chamber and the centrifugal pump and delivery pipe liver is installed, institute
Delivery pipe liver is stated through the inner wall between the storage box and the storage chamber, is connected between the centrifugal pump and the filling oxygen chamber
Logical to be equipped with straight tube, the straight tube is located at filling oxygen chamber lower portion and is fixedly installed with check valve, the filling oxygen chamber with it is described
Connection is equipped with delivery pipe between blood chamber.
In addition, in one embodiment, being installed with pressure gauge in the upper inside walls of the emulation chamber, the pressure gauge is downward
It is intracavitary that the emulation is protruded into extension, and is located on the periphery for emulating the intracavitary pressure gauge and is installed with sealing ring,
The pressure gauge, which upwardly extends, to be partially protruded into the working chamber, and the top surface of the pressure gauge is installed with storage box, it is described from
The top surface of heart pump is installed with electrical contact, is electrically connected live wire between the electrical contact and the storage box.
In addition, in one embodiment, the Guan Yang mechanism includes oxygen cylinder, and the right side of the main body is installed with folder
Set, the oxygen cylinder can be fixedly mounted in the collet, be connected between the oxygen cylinder and the filling oxygen chamber and be equipped with oxygen
Pipe, the another side of the oxygen hose are fixedly installed with syringe, and the upside connection for filling oxygen chamber is equipped with liquid inlet, it is described enter
Closing cap is rotatably equipped on the upside of liquid mouth.
In addition, in one embodiment, in the left wall of the rectangular cavity, on the periphery for filling oxygen chamber and the emulation chamber
Left and right sides wall on be installed with attemperator.
The beneficial effects of the present invention are: the present invention can be such that in vitro animal's liver obtains by room temperature oxygen carrying perfusion technique
It is saved to long-time, the research to Liver Allograft Preservation technology can be further strengthened, can be existed with super high-emulation degree come simulated liver
The intracorporal environment of animal, wherein supporting mechanism can support liver, and emulation chamber can be enable to emulate liver vivo environment, shake
Liver activity can be promoted, swung by the movement rocked back and forth to emulate liver in the indirect movement of animal physical strength by shaking mechanism
Mechanism and pulse mechanism can add new blood to emulation is intracavitary in the form of exemplary pulse, and can prevent blood clotting, fill oxygen
Mechanism can give hemoperfusion oxygen, promote oxygen content.
Detailed description of the invention
Fig. 1 is inside overall structure diagram of the invention；
Fig. 2 is the enlarged diagram in Fig. 1 of the present invention at A；
Fig. 3 is the enlarged diagram in Fig. 1 of the present invention at B；
Fig. 4 is state diagram when swing mechanism and pulse mechanism are run in the present invention.
Specific embodiment
Below with reference to Fig. 1-4, the present invention is described in detail, for sake of convenience, now such as to hereafter described orientation regulation
Under: hereafter described front-rear direction up and down is consistent with the front-rear direction up and down of Fig. 1 projection relation itself.
Referring to Fig.1-4, the room temperature oxygen carrying device for casting of a kind of in vitro animal's liver of embodiment according to the present invention, including
Main body 66 offers working chamber 62 in the main body 66, is equipped with storage box 64, the storage box 64 in the working chamber 62
It is interior to be equipped with the openable emulation chamber 65 in front side, delivery pipe liver 47 can be stored in the emulation chamber 65, is set in the emulation chamber 65
It can support the delivery pipe liver 47, and the delivery pipe liver 47 can be made uprightly to store to promote the supporting mechanism of fidelity
101, the downside of the working chamber 62 offers drive cavity 43, is equipped in the drive cavity 43 and can control the storage box 64 around circle
Week centrifugation rotates the swaying mechanism 102 to prevent blood clotting in the emulation chamber 65, and the upside of the working chamber 62 offers
Rectangular cavity 16 is connected between the working chamber 62 and the rectangular cavity 16 and is equipped with pressing chamber 25, and being equipped in the rectangular cavity 16 can
To the bags of blood 17 of emulation 65 blood perfusion of chamber, blood chamber 19, the blood chamber 19 and institute are equipped in the bags of blood 17
It states connection between emulation chamber 65 and hose 21 is installed, the summit portion that the hose 21 is located at the storage box 64 is fixedly installed with
Orifice valve 26, the left side of the rectangular cavity 16 offer power cavity 11, and being equipped in the power cavity 11 can control the bags of blood
17 rock back and forth to prevent the swing mechanism 103 of blood clotting in the blood chamber 19, are equipped with briquetting in the pressing chamber 25
24, the downside of the power cavity 11 offers driven chamber 74, is equipped in the driven chamber 74 and can control 24 interval of briquetting
Property squeezes the pulse mechanism 104 of the hose 21, and the pulse mechanism 104 can make the blood in the blood chamber 19 to emulate arteries and veins
The form for rushing effect enters in the emulation chamber 65, and the right side opening of the rectangular cavity 16, which is equipped with, fills oxygen chamber 57, the filling oxygen chamber 57
Downside offer storage chamber 53, be installed with centrifugal pump 48 on 53 bottom wall of storage chamber, the centrifugal pump 48 can be described imitative
Blood in true chamber 65 is delivered in the filling oxygen chamber 57, to guarantee the blood circulation in the emulation chamber 65, the filling oxygen chamber
Oxygen can be filled with to increase the Guan Yang mechanism 105 of blood oxygen levels by being equipped in 57.
In addition, in one embodiment, the supporting mechanism 101 includes two groups of support plates 75, in the support plate 75
Equipped with card slot 77, it is installed with cushion 76 on the inner wall of the card slot 77, is installed with hinge bar in the left wall of the emulation chamber 65
41, it is hinged positioned at the bottom surface of the left side support plate 75 and the right side of the driven chamber 74, it is located at the right side support plate 75
Right side be installed with mobile bar 45, the inner wall of the storage box 64 is run through in extension to the mobile bar 45 to the right, and protrudes into
In the working chamber 62, and the right side of the mobile bar 45 is installed with manual disk 46, in the emulation chamber 65 described in
Sealing shroud 44 is fixedly installed on 45 periphery of mobile bar, the mobile bar 45 and the inner wall of the storage box 64 are slidably matched, institute
State delivery pipe liver 47 can inlay card in two card slots 77, by manually adjusting 46 left-right position of manual disk, can make
The delivery pipe liver 47 is more stable to be clamped in the card slot 77, and can guarantee that the delivery pipe liver 47 is upright.
In addition, in one embodiment, the swaying mechanism 102 includes first be installed on 43 bottom wall of drive cavity
Motor 42, the left and right sides of the first motor 42 are connected by power equipped with horizontal axis 36, and the another side of the horizontal axis 36 is solid
Equipped with first bevel gear 35, the left and right sides of the working chamber 62 offers gear cavity 30, the gear cavity 30 and the biography
Rotation is equipped with vertical pivot 33 in inner wall between dynamic chamber 43, and 33 downward extension portion of vertical pivot protrudes into the drive cavity 43
It is interior, and the bottom surface of the vertical pivot 33 is installed with second bevel gear 34, the second bevel gear 34 is nibbled with the first bevel gear 35
It closes, the vertical pivot 33 upwardly extends part and protrudes into the gear cavity 30, and the top surface of the vertical pivot 33 is installed with third cone
Gear 32, the gear cavity 30 and rotation in the inner wall of the working chamber 62 are equipped with short axle 37, the short axle 37 extension to the left
Divide and protrude into the gear cavity 30, and the left side of the short axle 37 is installed with the 4th bevel gear 31, the 4th bevel gear 31
It is engaged with the third hand tap gear 32, the short axle 37 to the right protrude into the working chamber 62 by extension, and the short axle
37 another side is installed with link block 38, and two link block 38 sides close to each other are installed with support shaft 39, and two
A support shaft 39 is fixedly connected with the storage box 64, by the slow operating of the first motor 42, can be made described
Horizontal axis 36 drives the gear cavity 30 to rotate, and so as to make the short axle 37 that the link block 38 be driven to rotate, and then can make institute
Stating support shaft 39 drives the storage box 64 to do slowly centrifugation rotation.
In addition, in one embodiment, the swing mechanism 103 includes second be installed in 11 left wall of power cavity
Motor 12, the right side power of second motor 12 are connected with driving shaft 67, and the right side of the driving shaft 67, which is installed with, to be turned
Disk 69, the top surface of the bags of blood 17 are installed with bracket 18, turn in the inner wall between the rectangular cavity 16 and the power cavity 11
Dynamic to be equipped with connecting rod 14, the connecting rod 14 to the right protrude into the rectangular cavity 16 by extension, and fixed with the bracket 18
Connection, the connecting rod 14 to the left protrude into the power cavity 11 by extension, and the left side of the connecting rod 14 is installed with
Turntable 13 is hingedly equipped with connecting rod 70 between the turntable 13 and the driving shaft 67, the radius of the turntable 13 is much larger than described
Turntable 69 can make the driving shaft 67 that the turntable 69 be driven to rotate, by the operating of second motor 12 so as to make
It states connecting rod 70 turntable 13 is driven to do circumference and rotate back and forth, and then can make the connecting rod 14 that the bracket 18 be driven to do circumference
Round-trip rotation, then can make the bags of blood 17 do circumference and rotate back and forth, can then prevent the blood clotting in the blood chamber 19.
In addition, in one embodiment, the pulse mechanism 104 includes that rotation is located at the power cavity 11 and described driven
Driven shaft 72 between chamber 74 in inner wall, the driven shaft 72, which upwardly extends, to be partially protruded into the power cavity 11, and it is described from
The top surface of moving axis 72 is installed with the 5th bevel gear 71, is installed with the 6th bevel gear 68 on the periphery of the driving shaft 67, and described
Six bevel gears 68 engage with the 5th bevel gear 71, and 72 downward extension portion of driven shaft protrudes into the driven chamber 74,
And the bottom surface of the driven shaft 72 is installed with runner 73, connection is equipped with sliding cavity between the driven chamber 74 and the pressing chamber 25
23, sliding is equipped with cross bar 22 on the bottom wall of the sliding cavity 23, and the driven chamber 74 is protruded into extension to the cross bar 22 to the left
Interior and hinged with the runner 73, the cross bar 22 to the right protrude into the pressing chamber 25 by extension, the pressing chamber 25
Left side is fixedly connected with the right side of the cross bar 22, by the operating of second motor 12, can make the driving shaft 67
It drives the driven shaft 72 to rotate, and then can make the runner 73 that the cross bar 22 be driven to do left and right back and forth movement, then can make institute
The intermittent extruding hose 21 of briquetting 24 is stated, can then make blood in the hose 21 that can enter described imitate with impulse form
In true chamber 65.
In addition, in one embodiment, being connected between the emulation chamber 65 and the centrifugal pump 48 and being equipped with delivery pipe liver
Dirty 47, the delivery pipe liver 47 through inner wall between the storage box 64 and the storage chamber 53, the centrifugal pump 48 with
Connection is equipped with straight tube 51 between the filling oxygen chamber 57, and the straight tube 51 is located at 57 lower portion of filling oxygen chamber and is fixedly installed with
Check valve 55 is connected between the filling oxygen chamber 57 and the blood chamber 19 and is equipped with delivery pipe 20, passes through the centrifugal pump 48
Operating, can make the blood circulation in whole device.
In addition, in one embodiment, being installed with pressure gauge 28, the pressure gauge in the upper inside walls of the emulation chamber 65
28 downward extension portions protrude into the emulation chamber 65, and solid on the periphery for the pressure gauge 28 being located in the emulation chamber 65
Equipped with sealing ring 29, the pressure gauge 28, which upwardly extends, to be partially protruded into the working chamber 62, and the top surface of the pressure gauge 28
Be installed with storage box 64, the top surface of the centrifugal pump 48 is installed with electrical contact 49, the electrical contact 49 and the storage box 64 it
Between be electrically connected live wire 50, when it is described emulation chamber 65 in liquid level decline cause pressure to reduce when, the pressure gauge 28 can lead to
It crosses the electric wire 50 and controls the centrifugal pump 48 and shut down, when the 65 internal pressure strong stability of emulation chamber, the pressure gauge 28
The centrifugal pump 48 can control to start, to can guarantee that the blood environment in the emulation chamber 65 is stablized.
In addition, in one embodiment, the Guan Yang mechanism 105 includes oxygen cylinder 54, the right side of the main body 66
It is installed with collet 52, the oxygen cylinder 54 can be fixedly mounted in the collet 52, the oxygen cylinder 54 and the filling oxygen chamber 57
Between connection oxygen hose 58 is installed, the another side of the oxygen hose 58 is fixedly installed with syringe 59, the filling oxygen chamber 57
Upside connection be equipped with liquid inlet 60, the upside of the liquid inlet 60 is rotatably equipped with closing cap 61, described by opening manually
Closing cap 61, can initial blood amount needed for adding apparatus the oxygen cylinder 54 can be made to pass through by opening the oxygen cylinder 54
The oxygen hose 58 and the syringe 59 pour oxygen into the blood in the filling oxygen chamber 57, and then can increase taking for blood
Oxygen amount.
In addition, in one embodiment, in the left wall of the rectangular cavity 16, on the periphery for filling oxygen chamber 57 and described imitative
It is installed with attemperator 40 on the left and right sides wall of true chamber 65, can guarantee that blood is always in device by the attemperator 40
In normal temperature state.
When in use, can make delivery pipe liver 47 is more stable to clamp by manually adjusting manual 46 left-right position of disk
It in card slot 77, and can guarantee that delivery pipe liver 47 is upright, by the slow operating of first motor 42, horizontal axis 36 can be made with moving gear
Chamber 30 rotates, and so as to make short axle 37 that link block 38 be driven to rotate, and then can make support shaft 39 that storage box 64 be driven to do slowly
Centrifugation rotation can make driving shaft 67 that turntable 69 be driven to rotate, by the operating of the second motor 12 so as to make connecting rod 70 with turn
Disk 13 does circumference and rotates back and forth, and then can make connecting rod 14 that bracket 18 be driven to do circumference and rotate back and forth, then bags of blood 17 can be made to do
Circumference rotates back and forth, can then prevent the blood clotting in blood chamber 19, by the operating of the second motor 12, can make driving shaft 67
It drives driven shaft 72 to rotate, and then can make runner 73 that cross bar 22 be driven to do left and right back and forth movement, then briquetting 24 can be made intermittent
Squeezing tube 21 can then make in hose 21 blood that can enter with impulse form in emulation chamber 65, by the operating of centrifugal pump 48,
It can make the blood circulation in whole device, when emulating the liquid level decline in chamber 65 causes pressure to reduce, pressure gauge 28 can pass through
Electric wire 50 controls centrifugal pump 48 and shuts down, and when emulating 65 internal pressure strong stability of chamber, pressure gauge 28 can control centrifugal pump 48 to start,
It, can be initial needed for adding apparatus by opening closing cap 61 manually to can guarantee that the blood environment in emulation chamber 65 is stablized
Blood volume can make oxygen cylinder 54 by oxygen hose 58 and syringe 59 toward the blood filled in oxygen chamber 57 by opening oxygen cylinder 54
In pour oxygen, and then the oxygen carrying content of blood can be increased, can guarantee that blood is in room temperature always in device by attemperator 40
State.
The beneficial effects of the present invention are: the present invention can be such that in vitro animal's liver obtains by room temperature oxygen carrying perfusion technique
It is saved to long-time, the research to Liver Allograft Preservation technology can be further strengthened, can be existed with super high-emulation degree come simulated liver
The intracorporal environment of animal, wherein supporting mechanism can support liver, and emulation chamber can be enable to emulate liver vivo environment, shake
Liver activity can be promoted, swung by the movement rocked back and forth to emulate liver in the indirect movement of animal physical strength by shaking mechanism
Mechanism and pulse mechanism can add new blood to emulation is intracavitary in the form of exemplary pulse, and can prevent blood clotting, fill oxygen
Mechanism can give hemoperfusion oxygen, promote oxygen content.
Those skilled in the art can define, can in the case of not departing from overall spirit of the invention and design
To make the various modifications for above embodiments.It falls within the scope of protection of the present invention.Protection scheme of the invention
It is subject to claims appended hereto.
Claims (9)
1. a kind of room temperature oxygen carrying device for casting of in vitro animal's liver, including main body, it is characterised in that: opened in the main body
Equipped with working chamber, it is equipped with storage box in the working chamber, is equipped with the openable emulation chamber in front side, the emulation in the storage box
Intracavitary to store delivery pipe liver, intracavitary be equipped with of the emulation can support the delivery pipe liver, and can make the delivery pipe liver
Dirty upright storage promotes the supporting mechanism of fidelity, offers drive cavity on the downside of the working chamber, sets in the drive cavity
There are the swaying mechanism that can control the storage box to be circumferentially centrifuged rotation to prevent the emulation intracavity blood from condensing, the work
Rectangular cavity is offered on the upside of chamber, is connected between the working chamber and the rectangular cavity and is equipped with pressing chamber, sets in the rectangular cavity
Having can be to the bags of blood of the emulation chamber blood perfusion, and the bags of blood is interior to be equipped with blood chamber, the blood chamber and the emulation
Connection is equipped with hose between chamber, and the summit portion that the hose is located at the storage box is fixedly installed with orifice valve, the square
Power cavity is offered on the left of shape chamber, being equipped in the power cavity can control the bags of blood to rock back and forth to prevent the blood
The swing mechanism of intracavity blood condensation；
The pressing is intracavitary to be equipped with briquetting, and driven chamber is offered on the downside of the power cavity, described driven intracavitary equipped with controllable
Make the pulse mechanism that the briquetting intermittence squeezes the hose, the pulse mechanism can make the blood in the blood chamber with
The form of exemplary pulse effect is intracavitary into the emulation, and the right side opening of the rectangular cavity, which is equipped with, fills oxygen chamber, the filling oxygen chamber
Downside offers storage chamber, and centrifugal pump, the blood that the centrifugal pump can be intracavitary the emulation are installed on the storage chamber bottom wall
Liquid is delivered to that the filling oxygen is intracavitary, and to guarantee the intracavitary blood circulation of the emulation, the fillings oxygen is intracavitary equipped with can be filled with oxygen
To increase the Guan Yang mechanism of blood oxygen levels.
2. a kind of room temperature oxygen carrying device for casting of in vitro animal's liver according to claim 1, it is characterised in that: the branch
Support mechanism includes two groups of support plates, is equipped with card slot in the support plate, cushion is installed on the inner wall of the card slot, described
It emulates and is installed with hinge bar in the left wall of chamber, it is hinged positioned at the bottom surface of the left side support plate and the right side of the driven chamber,
It is installed with mobile bar positioned at the right side of the right side support plate, the storage box is run through in extension to the mobile bar to the right
Inner wall, and protrude into the working chamber, and the right side of the mobile bar is installed with manual disk, the institute intracavitary positioned at the emulation
It states and is fixedly installed with sealing shroud on mobile bar periphery, the mobile bar and the inner wall of the storage box are slidably matched, the discharge
Pipe liver can inlay card in two card slots.
3. a kind of room temperature oxygen carrying device for casting of in vitro animal's liver according to claim 1, it is characterised in that: described to shake
Shaking mechanism includes the first motor being installed on the drive cavity bottom wall, and the left and right sides of the first motor, which is connected by power, to be set
There is horizontal axis, the another side of the horizontal axis is installed with first bevel gear, and the left and right sides of the working chamber offers gear
Chamber, rotation is equipped with vertical pivot in the inner wall between the gear cavity and the drive cavity, and the vertical pivot downward extension portion is stretched
Enter in the drive cavity, and the bottom surface of the vertical pivot is installed with second bevel gear, the second bevel gear and the first cone tooth
Wheel engagement, the vertical pivot upwardly extends part and protrudes into the gear cavity, and the top surface of the vertical pivot is installed with triconodont
Rotation is equipped with short axle in the inner wall of wheel, the gear cavity and the working chamber, and the tooth is protruded into extension to the short axle to the left
Take turns intracavitary, and the left side of the short axle is installed with the 4th bevel gear, and the 4th bevel gear engages with the third hand tap gear,
The short axle to the right protrude into the working chamber by extension, and the another side of the short axle is installed with link block, and two
A link block side close to each other is installed with support shaft, and two support shafts are fixedly connected with the storage box.
4. a kind of room temperature oxygen carrying device for casting of in vitro animal's liver according to claim 1, it is characterised in that: the pendulum
Motivation structure includes the second motor being installed in the power cavity left wall, and the right side power of second motor is connected with actively
Axis, the right side of the driving shaft are installed with turntable, and the top surface of the bags of blood is installed with bracket, and the rectangular cavity is moved with described
In inner wall between power chamber rotation be equipped with connecting rod, the connecting rod to the right protrude into the rectangular cavity by extension, and with institute
It states bracket to be fixedly connected, the connecting rod to the left protrude into the power cavity by extension, and the left side of the connecting rod is solid
Equipped with turntable, connecting rod is hingedly equipped between the turntable and the driving shaft, the radius of the turntable is much larger than the turntable.
5. a kind of room temperature oxygen carrying device for casting of in vitro animal's liver according to claim 4, it is characterised in that: the arteries and veins
Punch mechanism includes rotating the driven shaft being located between the power cavity and the driven chamber in inner wall, and the driven shaft upwardly extends
It partially protrudes into the power cavity, and the top surface of the driven shaft is installed with the 5th bevel gear, consolidates on the periphery of the driving shaft
Equipped with the 6th bevel gear, the 6th bevel gear engages with the 5th bevel gear, and the driven shaft downward extension portion protrudes into
It is described driven intracavitary, and the bottom surface of the driven shaft is installed with runner, is connected to and is equipped between the driven chamber and the pressing chamber
Sliding cavity, sliding is equipped with cross bar on the bottom wall of the sliding cavity, the cross bar to the left extension protrude into it is described driven intracavitary, and
It is hinged with the runner, the cross bar to the right extension protrude into it is described pressing it is intracavitary, it is described pressing chamber left side with it is described
The right side of cross bar is fixedly connected.
6. a kind of room temperature oxygen carrying device for casting of in vitro animal's liver according to claim 1, it is characterised in that: described imitative
It is connected between true chamber and the centrifugal pump and delivery pipe liver is installed, the delivery pipe liver is deposited through the storage box with described
The inner wall between chamber is put, is connected between the centrifugal pump and the filling oxygen chamber and straight tube is installed, the straight tube is located at the filling oxygen
Chamber lower portion is fixedly installed with check valve, is connected between the filling oxygen chamber and the blood chamber and is equipped with delivery pipe.
7. a kind of room temperature oxygen carrying device for casting of in vitro animal's liver according to claim 6, it is characterised in that: described imitative
Pressure gauge is installed in the upper inside walls of true chamber, it is intracavitary that the pressure gauge downward extension portion protrudes into the emulation, and is located at institute
It states and is installed with sealing ring on the periphery for emulating the intracavitary pressure gauge, the pressure gauge, which upwardly extends, partially protrudes into the work
Intracavitary, and the top surface of the pressure gauge is installed with storage box, the top surface of the centrifugal pump is installed with electrical contact, the electrical contact with
Live wire is electrically connected between the storage box.
8. a kind of room temperature oxygen carrying device for casting of in vitro animal's liver according to claim 1, it is characterised in that: the filling
Oxygen mechanism includes oxygen cylinder, and the right side of the main body is installed with collet, and the oxygen cylinder can be fixedly mounted on the collet
It is interior, it is connected between the oxygen cylinder and the filling oxygen chamber and oxygen hose is installed, the another side of the oxygen hose is fixedly installed with
Syringe, the upside connection for filling oxygen chamber are equipped with liquid inlet, are rotatably equipped with closing cap on the upside of the liquid inlet.
9. a kind of room temperature oxygen carrying device for casting of in vitro animal's liver according to claim 1, it is characterised in that: the square
In the left wall of shape chamber, it is described fill oxygen chamber periphery on and it is described emulation chamber left and right sides wall on be installed with attemperator.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910841432.8A CN110402921A (en) | 2019-09-06 | 2019-09-06 | A kind of room temperature oxygen carrying device for casting of in vitro animal's liver |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910841432.8A CN110402921A (en) | 2019-09-06 | 2019-09-06 | A kind of room temperature oxygen carrying device for casting of in vitro animal's liver |
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| Publication Number | Publication Date |
|---|---|
| CN110402921A true CN110402921A (en) | 2019-11-05 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910841432.8A Withdrawn CN110402921A (en) | 2019-09-06 | 2019-09-06 | A kind of room temperature oxygen carrying device for casting of in vitro animal's liver |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112772632A (en) * | 2020-12-31 | 2021-05-11 | 重庆北部宽仁医院 | Isolated liver perfusion device |
| WO2022137164A1 (en) * | 2020-12-22 | 2022-06-30 | Polbionica Sp. Z O.O. | A system for storing or cultivating of an organ or tissue model and uses thereof |
-
2019
- 2019-09-06 CN CN201910841432.8A patent/CN110402921A/en not_active Withdrawn
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2022137164A1 (en) * | 2020-12-22 | 2022-06-30 | Polbionica Sp. Z O.O. | A system for storing or cultivating of an organ or tissue model and uses thereof |
| CN112772632A (en) * | 2020-12-31 | 2021-05-11 | 重庆北部宽仁医院 | Isolated liver perfusion device |
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Application publication date: 20191105 |