CN110391011A - Light jejunitas personalized intervention stratege management system - Google Patents

Light jejunitas personalized intervention stratege management system Download PDF

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Publication number
CN110391011A
CN110391011A CN201910515193.7A CN201910515193A CN110391011A CN 110391011 A CN110391011 A CN 110391011A CN 201910515193 A CN201910515193 A CN 201910515193A CN 110391011 A CN110391011 A CN 110391011A
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type
individual
specific
constitution
jejunitas
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毛丹丹
傅咏南
王校
陆婧
卞雪莲
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Shanghai Likang Precision Medical Technology Co ltd
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Shanghai Excellent Precision Medical Polytron Technologies Inc
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Priority to CN201910515193.7A priority Critical patent/CN110391011A/en
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    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16HHEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H20/00ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
    • G16H20/60ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to nutrition control, e.g. diets

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  • Health & Medical Sciences (AREA)
  • Nutrition Science (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medical Informatics (AREA)
  • Primary Health Care (AREA)
  • Public Health (AREA)
  • Medical Treatment And Welfare Office Work (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

It obtains individual inheritance genetic test result type, constitution type in TCM, sub-health state and whether has anaphylactogen;Each type corresponds to specific juice in query gene testing result type and weighted value, inquiry constitution type in TCM correspond to specific cereal, inquires each type in sub-health state and corresponds to specific cereal and weighted value;Specific juice corresponding to genetic test result type sorts according to respective weights value, and specific cereal corresponding to sub-health state type sorts according to respective weights value;The specific juice of M before selecting ranking in the corresponding sequence of genetic testing result type, the specific cereal of N, selects the corresponding specific cereal of constitution type in TCM before selecting ranking in the corresponding sequence of sub-health state type;The food for belonging to anaphylactogen in the specific cereal and the corresponding specific cereal of constitution type in TCM of N before the specific juice of M, ranking before the ranking of individual is replaced with into the close food without anaphylactogen of function to form light jejunitas personalized intervention stratege.

Description

Light jejunitas personalized intervention stratege management system
Technical field
The present invention relates to health control technical fields, more particularly to a kind of light jejunitas personalized intervention stratege management system System.
Background technique
Light jejunitas once widespread is in Buddhism monk, Yoga passerby.These personal materials are very lean, full of vitality, health It is long-lived.But for ordinary populace, it is light it is jejunitas be always it is ignored, until 2012, Michael Mo Sili doctor Primary weight-reducing research, just promote him to seek answer in jejunitas.He has visited the scientist of forefront, studies jejunitas ancient Religion, bold combines the jejunitas experience of religion with contemporary science, and is promoted.It is reported that gently jejunitas is that people is allowed to return Return natural diet state: 5 days normal diets weekly, only needs slightly control within two days, can preferably maintain weight.
More popular light jejunitas method is eaten using juice generation currently on the market, but often both for general population General side, other season side preferably at most there emerged a according to season, do not account for Different Individual constitution difference, do not have yet it is a set of rationally The light jejunitas intervention stratege of personalization presentment system.
The reason of in place of existing light jejunitas intervention stratege Shortcomings is: intervention stratege is not analyzed in acquisition process Genetic constitution, traditional Chinese medicine constitution typing, sub-health state and the allergic conditions of individual can not be provided for the personalized light of individual Jejunitas scheme can not carry out analysis according to these information and automatically obtain personalized light jejunitas scheme.
Summary of the invention
The present invention is in view of the problems of the existing technology and insufficient, provides a kind of light jejunitas personalized intervention stratege management system System.
The present invention is to solve above-mentioned technical problem by following technical proposals:
The present invention provides a kind of light jejunitas personalized intervention stratege management system, it is characterized in that comprising acquisition of information Module, enquiry module, sorting module, selecting module and replacement module;
The data obtaining module is used to obtain the genetic testing result type of individual, constitution type in TCM, sub- strong Health Status Type and whether there are allergens;
The enquiry module is for the corresponding specific fruit of type each in the genetic testing result type of querying individual The corresponding specific cereal of constitution type in TCM of vegetable juice and the corresponding weighted value of each specific juice, querying individual, inquiry Each corresponding specific cereal of type and the corresponding weighted value of each specific cereal in personal sub-health state type;
The sorting module be used for the personal corresponding all specific juice of genetic testing result type according to Respective weights are worth descending sequence and are ranked up, to the personal corresponding all specific cereal of sub-health state type according to Respective weights are worth descending sequence and are ranked up;
The selecting module is used for the M before selecting ranking in the personal corresponding sequence of genetic testing result type Specific juice, the specific cereal of N, selection before selecting ranking in the personal corresponding sequence of sub-health state type The corresponding specific cereal of the constitution type in TCM of people, M, N are positive integer;
The replacement module is used in the case where individual has allergens, by the specific fruit of M before the ranking of individual The food for belonging to anaphylactogen before vegetable juice, ranking in the specific cereal of N and the corresponding specific cereal of constitution type in TCM replaces with function The close food without anaphylactogen of energy, to form the light jejunitas personalized intervention stratege of individual.
Preferably, individual constitution is divided into eight kinds according to gene: lipid-metabolism type, energy imbalance type, toxin are accumulated Type, nervous centralis type, hyperinsulinism type, low adrenaline type, hormone is unbalance type and normal type;
The data obtaining module is used for:
It obtains to the corresponding relevant gene polymorphism sites of type each in eight seed types, each gene that determination obtains is more The single-gene risk of the different genotype in state property site;
The gene polymorphism sites that will acquire carry out permutation and combination according to genotype, and the risk for calculating each permutation and combination multiplies Product, the single-gene risk that the risk product of permutation and combination is equal to each genotype of the permutation and combination are multiplied;
Each risk product is ranked up according to ascending or descending sequence, and merges risk product phase Same permutation and combination, the risk height of each permutation and combination is determined according to the size of risk product, is greater than 1 in risk product When individual belong to the corresponding individual somatotypes of gene polymorphism sites, when risk product is equal to 1, individual is not belonging to gene The corresponding individual somatotypes of polymorphic site;
Risk product is greater than 1 corresponding individual somatotypes as genetic testing result type.
Preferably, individual constitution is divided into nine kinds according to tcm constitution: gentle matter, deficiency of vital energy matter, deficiency of yang matter, deficiency of Yin matter, phlegm Wet matter, damp and hot matter, blood stasis matter, obstruction of the circulation of vital energy matter and special official report matter;
The data obtaining module is used to collect individual constitution type in TCM by questionnaire form.
Preferably, sub-health state type include fatty liver, hypertension, hyperglycemia, hyperlipidemia, thyroid gland problem, stomach trouble, Sleeping problems, toxin accumulation-liver, toxin accumulation-spleen, toxin accumulation-kidney, the toxin accumulation-heart, toxin accumulation-lung;
The data obtaining module is used for blood pressure, blood glucose, the blood lipid, thyroid gland situation, liver situation obtained by physical examination Etc. indexs, to deviate normal value index carry out crawl analysis to obtain sub-health state type.
Preferably, the data obtaining module is used to collect whether individual has allergens by questionnaire form.
On the basis of common knowledge of the art, above-mentioned each optimum condition, can any combination to get each preferable reality of the present invention Example.
The positive effect of the present invention is that:
This system assigns the indexs such as gene, tcm constitution, sub-health state, the allergy of the individual being collected into Value, the scheme for taking assignment forward after unified operation realize personalized light jejunitas scheme and automate the purpose provided.
This system is provided with allergy alternative specifically for the crowd of allergic constitution, i.e., if the personalization normally provided is light It can be replaced the similar scheme for being free of anaphylactogen of function comprising anaphylactogen (such as almond) in jejunitas scheme, solve allergy body Matter crowd is not suitable for the problem of intervening.
This system can carry out real-time update to individual indices, and rerun and obtain personalized light jejunitas intervention Scheme solves the problems, such as that existing light jejunitas scheme cannot be adjusted according to ownness.
Detailed description of the invention
Fig. 1 is the structural block diagram of the light jejunitas personalized intervention stratege management system of present pre-ferred embodiments.
Specific embodiment
In order to make the object, technical scheme and advantages of the embodiment of the invention clearer, below in conjunction with the embodiment of the present invention In attached drawing, technical scheme in the embodiment of the invention is clearly and completely described, it is clear that described embodiment is A part of the embodiment of the present invention, instead of all the embodiments.Based on the embodiments of the present invention, those of ordinary skill in the art Every other embodiment obtained without making creative work, shall fall within the protection scope of the present invention.
As shown in Figure 1, the present embodiment provides a kind of light jejunitas personalized intervention stratege management systems comprising acquisition of information Module 1, enquiry module 2, sorting module 3, selecting module 4 and replacement module 5.
The data obtaining module 1 is used to obtain the genetic testing result type of individual, constitution type in TCM, sub- strong Health Status Type and whether there are allergens.
Specifically, individual constitution is divided into eight kinds according to gene: lipid-metabolism type, energy imbalance type, toxin are accumulated Type, nervous centralis type, hyperinsulinism type, low adrenaline type, hormone is unbalance type and normal type.
It obtains to the corresponding relevant gene polymorphism sites of type each in eight seed types, each gene that determination obtains is more The single-gene risk of the different genotype in state property site.
The gene polymorphism sites that will acquire carry out permutation and combination according to genotype, and the risk for calculating each permutation and combination multiplies Product, the single-gene risk that the risk product of permutation and combination is equal to each genotype of the permutation and combination are multiplied.
Each risk product is ranked up according to ascending or descending sequence, and merges risk product phase Same permutation and combination, the risk height of each permutation and combination is determined according to the size of risk product, is greater than 1 in risk product When individual belong to the corresponding individual somatotypes of gene polymorphism sites, when risk product is equal to 1, individual is not belonging to gene The corresponding individual somatotypes of polymorphic site.
Risk product is greater than 1 corresponding individual somatotypes and is used as genetic testing result type, for personalization The screening of juice in light jejunitas scheme.
The method for building up of risk of obesity grade is shown by taking " energy imbalance type is fat " as an example:
(1) selection gene polymorphism sites relevant with energy imbalance type obesity, data provided according to document or voluntarily The single-gene risk of the different genotype in each genetic risk factors related polymorphic site is determined in sampling.
(2) by each genotype permutation and combination of all polymorphic sites of use, then multiplied according to each single-gene risk Product establishes Polymorphism type risk class.
Determine the specific method of the single-gene risk of the different genotype in each genetic risk factors related polymorphic site Are as follows:
A. case-control study method is utilized, using Chi-square Test or Fisher precise probabilistic method, credibility interval CI 95% is taken, significant difference takes p < 0.05, to the relevant bits of genetic risk factors of the energy imbalance type obesity in specific crowd Point is screened.
B. relative risk OR is calculated using SPSS statistics software, CI takes 95%, p < 0.05, as each related polymorphic The single-gene risk of site different genotype.
Selection can be according in documents searching Chinese population to the fat relevant gene polymorphism sites of energy imbalance type The fat common genetic risk factors of energy imbalance type are selected.
To the fat relevant gene polymorphic position property point of energy imbalance type in the following table 1 at least two:
Table 1
It is consulted according to the molecular epidemiology related research result in extensive Chinese population, each correlation in the upper table adopted The risk of polymorphic site is as shown in table 2 below:
Table 2
The foundation of risk of obesity grade specifically:
Each there are three types of hypotypes respectively to the fat relevant gene polymorphism sites of energy imbalance type, and selected site is owned What hypotype occurred can be carried out permutation and combination;Then the risk of these hypotypes is multiplied and obtains the risk of different permutation and combination Product;The risk product of acquisition is arranged from small to large or from big to small, merges the equal group of risk product;Finally press wind The size of dangerous degree product determines the height of each group risk.
The above method is to be weighted processing for each site as independent factor, and risk product is bigger, assesses risk It is bigger;The Polymorphism type heredity high risk individual being calculated in aforementioned manners can be expressed as its own and cause energy imbalance type Fat genetic risk factors are more or result certainty is stronger.
Further, be a, b, c ... by different related polymorphic site-tags, by different hypotypes labeled as 1,2, 3, i.e. the haplotype of carrying 1 site hypotype 1+ of site, 2 site hypotype 1+, 3 hypotype 1 is expressed as a1b1c1;It is excellent in of the invention one It selects in embodiment, the related polymorphic site of selection is rs1800592 (UCP1), rs660339 (UCP2) and rs1042713 (ADRB2), they are respectively labeled as a, b, c, according to single-gene risk calculation risk degree product listed in above table The results are shown in Table 3:
Table 3
Risk product is programmed using PHP, is counted after then inputting each single-gene risk angle value in a computer It calculates.
Then the haplotype in upper table 3 is arranged and is grouped from low to high by risk product, as shown in table 4;Risk etc. Grade is higher, and risk product is bigger, i.e. the genetic risk of individual itself initiation energy imbalance type obesity is higher.
Table 4
Individual constitution is divided into nine kinds according to tcm constitution: gentle matter, deficiency of vital energy matter, deficiency of yang matter, deficiency of Yin matter, phlegm wet matter, wet Caloic, blood stasis matter, obstruction of the circulation of vital energy matter and special official report matter.
The data obtaining module is used to accumulate by questionnaire form collection traditional Chinese medicine constitution typing, sleeping problems, toxin dirty The indexs such as device obtain individual constitution type in TCM, the screening for cereal in personalized light jejunitas scheme.
Sub-health state type includes that fatty liver, hypertension, hyperglycemia, hyperlipidemia, thyroid gland problem, stomach trouble, sleep are asked Topic, toxin accumulation-liver, toxin accumulation-spleen, toxin accumulation-kidney, the toxin accumulation-heart, toxin accumulation-lung;
The data obtaining module is used for blood pressure, blood glucose, the blood lipid, thyroid gland situation, liver situation obtained by physical examination Etc. indexs, crawl analysis is carried out to obtain sub-health state type, for personalized light jejunitas side to the index for deviateing normal value The screening of cereal in case.
The data obtaining module is used to collect whether individual has allergens by questionnaire form, for personalized light Micro-adjustment after jejunitas option screening.
The enquiry module 2 is for the corresponding specific fruit of type each in the genetic testing result type of querying individual The corresponding specific cereal of constitution type in TCM of vegetable juice and the corresponding weighted value of each specific juice, querying individual, inquiry Each corresponding specific cereal of type and the corresponding weighted value of each specific cereal in personal sub-health state type.
The sorting module 3 be used for the personal corresponding all specific juice of genetic testing result type according to Respective weights are worth descending sequence and are ranked up, to the personal corresponding all specific cereal of sub-health state type according to Respective weights are worth descending sequence and are ranked up.
The selecting module 4 is used for before selecting ranking in the personal corresponding sequence of genetic testing result type The specific juice of M, the specific cereal of N, selection before selecting ranking in the personal corresponding sequence of sub-health state type The personal corresponding specific cereal of constitution type in TCM, M, N are positive integer.
The replacement module 5 is used in the case where individual has allergens, by the specific fruit of M before the ranking of individual The food for belonging to anaphylactogen before vegetable juice, ranking in the specific cereal of N and the corresponding specific cereal of constitution type in TCM replaces with function The close food without anaphylactogen of energy, to form the light jejunitas personalized intervention stratege of individual.
Nutrigenomics are intervened theory with Chinese medicine conditioning and are used for providing for personalized light jejunitas scheme by this system, will be a The form of the light automatic presentment system application software of jejunitas scheme of propertyization shows, it is final realize personalized light jejunitas scheme from It is dynamic to dissolve tool.
1) according to genotype, traditional Chinese medicine constitution typing and the sub-health state of individual, classify to obesity phenotype, provide pair The personalized interference method answered, reaches control weight, reduces the purpose of sub-health state.
2) this system automatically generates intervention stratege according to indices assignment height, and as the variation of index can be real-time The adjustment of intervention stratege, such as the individual of initial phlegm wet matter are carried out, the influence of phlegm-dampness constitution weakens after conditioning, deficiency of vital energy qualitative change To need the constitution improved, means of intervention will carry out adjustment appropriate as needed.
3) adjustment for the scheme that this system can intervene the individual of allergic constitution, expands audient crowd.
Although specific embodiments of the present invention have been described above, it will be appreciated by those of skill in the art that these It is merely illustrative of, protection scope of the present invention is defined by the appended claims.Those skilled in the art is not carrying on the back Under the premise of from the principle and substance of the present invention, many changes and modifications may be made, but these are changed Protection scope of the present invention is each fallen with modification.

Claims (5)

1. a kind of light jejunitas personalized intervention stratege management system, which is characterized in that it includes data obtaining module, inquiry mould Block, sorting module, selecting module and replacement module;
The data obtaining module is used to obtain the genetic testing result type of individual, constitution type in TCM, inferior health shape State type and whether there are allergens;
The enquiry module is for the corresponding specific juice of type each in the genetic testing result type of querying individual And the corresponding specific cereal of constitution type in TCM of the corresponding weighted value of each specific juice, querying individual, querying individual Sub-health state type in each corresponding specific cereal of type and the corresponding weighted value of each specific cereal;
The sorting module is used for the personal corresponding all specific juice of genetic testing result type according to correspondence The descending sequence of weighted value is ranked up, to the personal corresponding all specific cereal of sub-health state type according to correspondence The descending sequence of weighted value is ranked up;
The selecting module is used for the tool of the M before selecting ranking in the personal corresponding sequence of genetic testing result type Body juice, the specific cereal of N, selects individual's before selecting ranking in the personal corresponding sequence of sub-health state type The corresponding specific cereal of constitution type in TCM, M, N are positive integer;
The replacement module be used for individual have allergens in the case where, by individual ranking before M specific juice, Belonging to the food of anaphylactogen before ranking in the specific cereal of N and the corresponding specific cereal of constitution type in TCM, to replace with function close Food without anaphylactogen, to form the light jejunitas personalized intervention stratege of individual.
2. light jejunitas personalized intervention stratege management system as described in claim 1, which is characterized in that will according to gene Individual constitution is divided into eight kinds: lipid-metabolism type, energy imbalance type, toxin accumulation type, nervous centralis type, hyperinsulinism type, low kidney Upper parathyrine type, hormone are unbalance type and normal type;
The data obtaining module is used for:
It obtains and the corresponding relevant gene polymorphism sites of type each in eight seed types, the determining each gene pleiomorphism obtained The single-gene risk of the different genotype in site;
The gene polymorphism sites that will acquire carry out permutation and combination according to genotype, calculate the risk product of each permutation and combination, The single-gene risk that the risk product of permutation and combination is equal to each genotype of the permutation and combination is multiplied;
Each risk product is ranked up according to ascending or descending sequence, and it is identical to merge risk product Permutation and combination determines the risk height of each permutation and combination according to the size of risk product, a when risk product is greater than 1 Body belongs to the corresponding individual somatotypes of gene polymorphism sites, and when risk product is equal to 1, individual is not belonging to gene polymorphic Property site corresponding individual somatotypes;
Risk product is greater than 1 corresponding individual somatotypes as genetic testing result type.
3. light jejunitas personalized intervention stratege management system as described in claim 1, which is characterized in that will according to tcm constitution Individual constitution is divided into nine kinds: gentle matter, deficiency of vital energy matter, deficiency of yang matter, deficiency of Yin matter, phlegm wet matter, damp and hot matter, blood stasis matter, obstruction of the circulation of vital energy matter and spy Report matter;
The data obtaining module is used to collect individual constitution type in TCM by questionnaire form.
4. light jejunitas personalized intervention stratege management system as described in claim 1, which is characterized in that sub-health state type Including fatty liver, hypertension, hyperglycemia, hyperlipidemia, thyroid gland problem, stomach trouble, sleeping problems, toxin accumulation-liver, toxin product Tired-spleen, toxin accumulation-kidney, the toxin accumulation-heart, toxin accumulation-lung;
Blood pressure, blood glucose, blood lipid, thyroid gland situation, liver situation that the data obtaining module is used to obtain by physical examination etc. refers to Mark carries out crawl analysis to the index for deviateing normal value to obtain sub-health state type.
5. light jejunitas personalized intervention stratege management system as described in claim 1, which is characterized in that the acquisition of information mould Block is used to collect whether individual has allergens by questionnaire form.
CN201910515193.7A 2019-06-14 2019-06-14 Light jejunitas personalized intervention stratege management system Pending CN110391011A (en)

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Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050036677A1 (en) * 2001-07-31 2005-02-17 Mahmoud Ladjevardi Advanced cosmetic color analysis system and methods therefor
CN102768712A (en) * 2001-12-28 2012-11-07 佩尔蒂·莱赫滕迈基 Method and arrangement for arranging an information service to determine nutrition and/or medication
US20130006669A1 (en) * 2011-06-29 2013-01-03 Fujifilm Corporation Diagnosis Support System, Method and Program
CN105483234A (en) * 2015-12-26 2016-04-13 上海中优生物高科技有限责任公司 Hypertension-type obese gene individualization intervention composition and preparation method and system
CN106227861A (en) * 2016-07-29 2016-12-14 珠海善乐生健康信息咨询有限公司 Individual health data Mobile medical system
CN106777932A (en) * 2016-12-01 2017-05-31 戴宁军 Healthy diet inquiry system
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CN107194173A (en) * 2017-05-18 2017-09-22 北京恩福健康科技中心 Automatic intelligent harmony between man and nature Health intervention scheme generation system
US20180114602A1 (en) * 2012-09-21 2018-04-26 Md Revolution, Inc. Interactive graphical user interfaces for implementing personalized health and wellness programs
CN109036511A (en) * 2018-07-12 2018-12-18 北京智吃健康科技股份有限公司 Weight-losing scheme customizing method and device

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050036677A1 (en) * 2001-07-31 2005-02-17 Mahmoud Ladjevardi Advanced cosmetic color analysis system and methods therefor
CN102768712A (en) * 2001-12-28 2012-11-07 佩尔蒂·莱赫滕迈基 Method and arrangement for arranging an information service to determine nutrition and/or medication
US20130006669A1 (en) * 2011-06-29 2013-01-03 Fujifilm Corporation Diagnosis Support System, Method and Program
US20180114602A1 (en) * 2012-09-21 2018-04-26 Md Revolution, Inc. Interactive graphical user interfaces for implementing personalized health and wellness programs
CN105483234A (en) * 2015-12-26 2016-04-13 上海中优生物高科技有限责任公司 Hypertension-type obese gene individualization intervention composition and preparation method and system
CN106227861A (en) * 2016-07-29 2016-12-14 珠海善乐生健康信息咨询有限公司 Individual health data Mobile medical system
CN106777932A (en) * 2016-12-01 2017-05-31 戴宁军 Healthy diet inquiry system
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CN109036511A (en) * 2018-07-12 2018-12-18 北京智吃健康科技股份有限公司 Weight-losing scheme customizing method and device

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Application publication date: 20191029