CN110384485A - The detection method and device that body haemodynamics responds in external counterpulsation treatment - Google Patents
The detection method and device that body haemodynamics responds in external counterpulsation treatment Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/02028—Determining haemodynamic parameters not otherwise provided for, e.g. cardiac contractility or left ventricular ejection fraction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/021—Measuring pressure in heart or blood vessels
- A61B5/02108—Measuring pressure in heart or blood vessels from analysis of pulse wave characteristics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/026—Measuring blood flow
Abstract
The invention discloses the detection method and device that body haemodynamics in external counterpulsation treatment responds, blood vessel and blood flow state data are acquired before detection method includes: collection sampler's physiologic information, and counterpulsation is treated in vitro respectively and in treatment；Arterial tree is segmented based on artery Tree-structure Model, each blood vessel segment length of acquisition healthy volunteer and radius data are arranged baseline reference, construct arterial tree geometry solving model；Calculate and be arranged boundary condition, amendment and calibration condition, and solution calculating is carried out to flow and the pressure pulse wave distribution of arterial tree each position based on pulse wave transfer theory and model, it calculates before external counterpulsation treatment and the blood perfusion and blood pressure level of target blood section and internal organs in treatment.The present invention can analyze the instant hemodynamic Effects of external counterpulsation therapeutic intervention noninvasive, in real time and effectively, solve the technical bottleneck that current external counterpulsation therapy lacks effective hemodynamic Effects evaluation method immediately.
Description
Technical field
It is responded the present invention relates to body haemodynamics in medicine technology field more particularly to external counterpulsation treatment
Detection method and device.
Background technique
The working principle of external counterpulsation therapy is: special Air sac cover is wrapped up in shank and the buttocks segmentation of patient, by electricity
The ECG R wave of sub- control device detection patient, the systole phase and diastole of heart is calculated by electronic computer, accordingly in real time
Instruction compressed air source unit each section of air bag is inflated, is vented, in diastole, each section of air bag by remote and near-earth with about 50ms
The time difference sequential inflation, improve diastolic pressure, by arterial blood refoulement to above the waist, increase venous return, improve heart and brain kidney
Equal upper part of the body important organ blood perfusion；When heart enters the systole phase, synchronous exhaust, lower limb subtract computer instruction whole air bag rapidly
After pressure, auterial diastole receives the blood from aorta, so that the afterload of heart is mitigated.
The direct target of external counterpulsation treatment is to increase venous return, cardiac output, to make organ, tissue blood flow
Perfusion is improved, and the coronary artery blood supply of especially heart is significantly increased, and provides for ischemic patient effective instant
Haemodynamics is supported.Clinical external counterpulsation therapy is set up for myocardial ischemia, from instant hemodynamic benefit and
Non-invasive, convenience is set out, and is selected patient to refer to pulse wave as evaluation means and is calculated the finger arteries and veins volume wave D/S value conduct in treatment
Evaluation index, it is believed that D/S >=1.2 item coronary blood hydromechanics benefits to can reach clinical requirement.External counterpulsation is treated at present
Method is widely used in the treatment of heart and brain circulatory system ischemic disease, and indication includes coronary disease and angina pectoris, cerebral arterial thrombosis, sugar
Foot disease, sudden deafness etc. are urinated, and hemodynamic treats the evaluation mark for benefiting to continue to use traditional finger arteries and veins volume wave D/S >=1.2 immediately
It is quasi-.
However, the pulse wave of the positions such as the heart, brain, lower limb with refer to pulse wave be it is discrepant, especially when the circulatory system exist
When lesion, patch.Therefore, at present merely to refer to the D/S value of arteries and veins volume wave waveform as the instant of external counterpulsation treatment
The method of effect assessment standard is not accurate and there are great drawback, this is also that the patient of different diseases and individual difference connects
Often there is one of the basic reason of larger difference in curative effect after receiving external counterpulsation treatment.
In addition, current intervention measuring technique is since there are invasive without being suitable for external counterpulsation therapy, and it is non-intervention
Measuring technique is only capable of obtaining the blood flow velocity of part shallow-layer blood vessel.It either intervenes or non-intervention, is unable to effective evaluation body
The hemodynamic of the whole haemodynamics response especially significant points such as coronary artery, aorta of body in extracorporeal counterpulsation intervention
Situation.Fast-developing haemodynamics technology of numerical simulation is based especially on the one-dimensional mould of pulse wave transfer theory in recent years
Type provides new thinking for the Hydrodynamic character of effective evaluation body, however one-dimensional model still has limitation at present, builds
Mould is extremely time-consuming and expends, while pulse wave TRANSFER MODEL is exported with aortic valve, the blood flow wave at aorta ascendens is made
For unique entrance boundary condition, however due to closing diastole aortic valve, prevent one-dimensional model is from reflecting
External counterpulsation effect is needed to make model itself and significantly be improved to the intervention effect of diastolic wave out.
Summary of the invention
The technical problem to be solved in the present invention is that in view of the above drawbacks of the prior art, a kind of external counterpulsation is provided and is controlled
The detection and analysis method and device that body haemodynamics responds in treatment, it is intended to solve to be held according to finger arteries and veins merely in the prior art
Product wave D/S ratio is as evaluation index, the problem of the diastolic pressure being unable at accurate judgement target internal organs and blood perfusion effect；Solution
Certainly current pulse wave TRANSFER MODEL is not suitable for calculating under external counterpulsation effect intervention, body arterial tree blood flow pulse wave and pressure
The Solve problems of power pulse wave.
The technical proposal for solving the technical problem of the invention is as follows:
The detection method of body haemodynamics response in a kind of external counterpulsation treatment, wherein the described method includes:
The physiologic information of sampler is collected, and using before ultrasonic bedside machine difference in vitro counterpulsation therapeutic intervention and external anti-
It fights and the blood vessel of the sampler and the status data of blood flow is acquired in therapeutic intervention；
Arterial tree is segmented (26 sections) based on artery Tree-structure Model, and acquires the health aspiration for meeting preset requirement
Baseline reference is arranged in the vessel diameter data of person, is constructed according to the exponential model of artery structure and preset mathematical model dynamic
Arteries and veins tree geometrical model；
Setting solves boundary condition, amendment and calibration condition, and is based on the arterial tree geometrical model, the boundary condition
And amendment and calibration condition, situation and pulse wave are transmitted based on the pulse wave of pulse wave transfer theory and computation model to arterial tree
It is distributed and carries out numerical solution, the blood flow pulse of each vessel segment of arterial tree before acquisition external counterpulsation treatment and in treatment involves pressure
Pulse wave；
Using before the external counterpulsation treatment and treatment in arterial tree each position pulse wave calculated result, calculate analysis mesh
Mark vessel segment position, the blood perfusion situation of target internal organs and blood pressure conditions form external counterpulsation treatment by comparative analysis
Real-time hemodynamic effect appraisal report.
Preferably, the physiologic information includes: the height information of the sampler, weight information, gender information, age letter
Breath and health and fitness information.
Preferably, the blood vessel of the sampler and the status data of blood flow include: the left and right side of the sampler
Total artery, aorta ascendens, the blood flow velocity of arteria brachialis and the frequency spectrum of neck, vessel diameter data.
Preferably, the physiologic information for collecting sampler, and using ultrasonic bedside machine respectively in vitro before counterpulsation treatment
The blood vessel of the sampler and the status data of blood flow are acquired in external counterpulsation treatment, further includes:
Oversleeve type blood pressure measuring device is then utilized, the systolic pressure and diastolic pressure of the artery position of sampler are measured.
Preferably, described that arterial tree is segmented based on artery Tree-structure Model, and acquire and meet the strong of preset requirement
Baseline reference is arranged in each blood vessel segment length and internal diameter data of health volunteer, utilizes the exponential model of artery structure and default
Mathematical model calculates and constructs the arterial tree geometrical model of patient, comprising:
Artery is divided into upper layer artery and lower layer's artery, the upper layer artery and lower layer's arteriogenesis branch vessel network and
Artery tree construction；
Arterial tree is divided into 26 sections according to artery Tree-structure Model；
Meet the healthy volunteer's that age requirement, height requirement and physical condition require using blood vessel Enhanced CT
System vascular is taken length of vessel average value as baseline reference, is established and suffered from using preset mathematical model and baseline reference
The computation model of each segment length of person's arterial tree；Using the exponential model of artery structure, preset mathematical model and baseline reference,
Establish the internal diameter computation model of patient's arterial tree each section.
Preferably, the setting solves boundary condition, amendment and calibration condition, and based on the arterial tree geometrical model,
The boundary condition and amendment and calibration condition transmit the pulse wave of arterial tree based on pulse wave transfer theory and computation model
Situation and pulse wave, which are distributed, carries out numerical solution, the blood flow of each vessel segment of arterial tree before acquisition external counterpulsation treatment and in treatment
It feels one's pulse and involves pressure pulse wave, comprising:
Using the aorta ascendens blood flow wave of sampler, boundary condition is set；It is calculated using the blood pressure measurement of arteria brachialis
Export boundary condition；Based on pulse wave transfer theory and 1D wave propagation solving model, and combine arteria carotis communis and
The correction conditions and calibration condition that the blood flow wave setting of arteria brachialis solves, to before external counterpulsation therapeutic intervention and therapeutic intervention
In arterial tree pulse wave transmitting situation and pulse wave distribution situation solved；
Using before the external counterpulsation treatment and treatment in arterial tree each position pulse wave calculated result, calculate analysis mesh
The blood perfusion level and blood pressure level for marking vessel segment position, target internal organs, form the real-time blood flow of external counterpulsation therapeutic intervention
The report of kinetic effect assay.
The detection device of body haemodynamics response in a kind of external counterpulsation treatment, wherein the detection device includes:
Data collection module for collecting the physiologic information of sampler, and uses ultrasonic bedside machine difference counterpulsation in vitro
The blood vessel and blood flow state data of the sampler are acquired before treating and in external counterpulsation treatment；
Model construction module meets default want for being segmented, and acquiring to arterial tree based on artery Tree-structure Model
Baseline reference is arranged, according to the exponential model of artery structure in each blood vessel segment length and internal diameter data of the healthy volunteer asked
And preset mathematical model constructs arterial tree geometrical model；
Model solution module solves boundary condition, amendment and calibration condition for being arranged, and is based on the arterial tree geometry
Model, the boundary condition and amendment and calibration condition, based on pulse wave transfer theory and computation model to the pulse of arterial tree
Wave transmits situation and pulse wave is distributed and carries out numerical solution, each vessel segment of arterial tree before acquisition external counterpulsation treatment and in treatment
Blood flow pulse involve pressure pulse wave；
Model evaluation module, before utilizing the external counterpulsation treatment and in treatment based on the pulse wave of arterial tree each position
It calculates as a result, calculate the blood perfusion situation and blood pressure conditions at analysis target blood section position, target internal organs, by comparative analysis,
Form the real-time hemodynamic effect appraisal report of external counterpulsation treatment.
Preferably, the d arterial tree model building module includes:
First submodule, for utilize blood vessel enhanced CT technology, scan several examples meet age requirement, height require and
The system vascular for the healthy volunteer that physical condition requires obtains geological information；Using artery Tree-structure Model by heart cyclic system
System arterial tree is divided into 26 sections；Using the average value and arterial tree model of enhanced CT measurement data, human body heart circulation arterial system is established
The baseline model of system；
Second submodule, baseline model and patient for calculating mathematical model according to artery segment, using arterial system
Individual information calculates the length of each section of artery of patient；
Third submodule, for using color ultrasound technology and ultrasonic bedside machine, measure the arteria carotis communis of patient, aorta ascendens,
The internal diameter of arteria brachialis and femoral artery in this, as amendment and calibration condition, and combines the exponential model of artery structure and preset
Mathematical model calculates the inlet radius and exit radius of each section of artery of patient.
Preferably, the model solution module includes:
Entrance boundary condition setting submodule, for utilizing the aorta ascendens before sampler's external counterpulsation treatment and in treatment
Blood flow wave setting pulse wave transmit solution boundary condition；
Submodule is arranged in export boundary condition, for utilizing the arteria brachialis blood before sampler's external counterpulsation treatment and in treatment
Measurement data is pressed, using the export boundary condition of general lumped parameter calculation method computation model；
Model computational submodule, by combining based on one-dimensional pulse wave transfer theory and 1D wave propagation model
Calculate the blood flow pulse wave and pressure pulse wave of arterial tree each position；
Modifying model and calibration module, for the blood flow wave measurement data using arteria carotis communis and arteria brachialis, to above-mentioned dynamic
The pulse wave calculated result of arteries and veins tree is modified and calibrates, until result and amendment and calibration condition kissing that model is calculated
It closes, i.e., overall flow error is not more than 10%, and waveform maximum disparity is not more than 10%.
Preferably, the model evaluation module includes:
Blood perfusion evaluates submodule, exists for calculating and the important organs such as evaluation goal vessel segment and the heart, brain, kidney, lung
Blood perfusion level and blood flow redistribution characteristic in external counterpulsation therapeutic intervention；
Blood pressure evaluates submodule, is used for calculating and the important organs such as evaluation goal vessel segment and the heart, brain, kidney, lung in vitro
The variation characteristic of blood pressure level especially diastolic pressure in counterpulsation therapeutic intervention.
Beneficial effects of the present invention: the present invention passes through due to acquiring the blood vessel of sampler and the status data of blood flow
It is solved using pulse wave transfer theory and one-dimensional solving model and obtains the stream of arterial tree each position in external counterpulsation therapeutic intervention
It feels one's pulse and involves pressure pulse wave, solve in current external counterpulsation treatment, lack effectively monitoring and assessment body is especially heavy
The defect for wanting internal organs haemodynamics to respond has laid important basis for the precision development of therapy.
The present invention due to acquire aorta ascendens, arteria carotis communis, three positions of arteria brachialis blood flow velocity and frequency spectrum, and count
Calculate corresponding blood flow wave.By using aorta ascendens blood flow wave as model entrance boundary condition, arteria carotis communis
With arteria brachialis blood flow wave as amendment and calibration condition, solves one-dimensional pulse wave TRANSFER MODEL merely with aorta ascendens blood
For flow quantity wave as entrance boundary condition, the diastole pressurization wave that cannot calculate external counterpulsation generation transmits arterial tree pulse wave
The problem of influence, solves one-dimensional pulse wave TRANSFER MODEL and is not suitable for calculating body hemodynamic in external counterpulsation therapeutic intervention
The problem of learning response.
The present invention passes through benefit due to proposing a kind of quick, convenient, the inexpensive method for reconstructing of arterial tree geometrical characteristic
The system vascular for meeting several healthy volunteers of condition with the scanning of enhanced CT technology, takes its each section of length of vessel, internal diameter
Average value combines specific sampler (patient) arteria carotis communis, aorta ascendens, arteria brachialis and femoral artery as baseline reference
The ultrasonic measurement of internal diameter as a result, and arterial tree structure mathematics, calculate each section of arterial tree of sampler (patient) length and
Width solves current pulse wave computation model and needs to carry out systemic arterial blood vessel using enhanced CT or magnetic resonance (MRI) to sweep
It retouches, extracts time-consuming, consuming and the contrast agent problem influential on sampler that arterial tree information carries out geometrical reconstruction.
Detailed description of the invention
Fig. 1 is the preferable implementation for the detection method that body haemodynamics responds in external counterpulsation treatment provided by the invention
The flow chart of example.
Fig. 2 be in external counterpulsation treatment provided by the invention body haemodynamics respond detection method in human vas
Network and its corresponding artery tree structure diagram.
Fig. 3 be in external counterpulsation treatment provided by the invention body haemodynamics respond detection method in another artery
Tree construction schematic diagram.
Fig. 4 is the principle of work and power for the detection device that body haemodynamics responds in external counterpulsation treatment provided by the invention
Block diagram.
Specific embodiment
To make the objectives, technical solutions, and advantages of the present invention clearer and more explicit, right as follows in conjunction with drawings and embodiments
The present invention is further described.It should be appreciated that the specific embodiments described herein are merely illustrative of the present invention, and do not have to
It is of the invention in limiting.
The detection method that body haemodynamics responds in a kind of external counterpulsation treatment provided by the invention, can be applied to
In terminal.Wherein, terminal can be, but not limited to be various personal computers, laptop, mobile phone, tablet computer, vehicle mounted electric
Brain etc..Terminal of the invention uses multi-core processor.Wherein, the processor of terminal can be central processing unit (Central
Processing Unit, CPU), graphics processor (Graphics Processing Unit, GPU), video processing unit
At least one of (Video Processing Unit, VPU) etc..
The indication of external counterpulsation includes ischemic cardiovascular and cerebrovascular, peripheral blood vessel and tiny blood vessels disease at present, mainly
It include: (1) coronary heart diseases and angina pectoris, myocardial infarction.(2) cerebral arteriovenous malformation, cerebral thrombosis, cerebral embolism, shaking plasy,
Vertebral-basilar artery insufficiency, cerebrovascular accident sequelae.(3) Fundus oculi artery embolism, Central Serous retina, train of thought
Film lesion, optic atrophy.(4) sudden deafness.(5) diabetes caused by arteria pancreatica hardening blood supply insufficiency.(6) limb artery
Embolism.(7) because of the ischemic lesions sequelae caused by other artery sclerosis and blood circulation disorder.(8) sports are tired
Labor, rehabilitation and health care.
The working principle of external counterpulsation is: special Air sac cover is wrapped up in shank and the buttocks segmentation of patient, by electronics control
The ECG R wave of system detection patient processed, is calculated the systole phase and diastole of heart in real time by electronic computer, instructed accordingly
Air supply system is inflated each section of air bag, is vented, in diastole, each section of air bag by remote and near-earth with about 50ms when
The sequential inflation of difference, improves diastolic pressure, by arterial blood refoulement to above the waist, increases venous return, improves on heart and brain kidney etc.
Half body important organ blood perfusion；When heart enters systole phase, the synchronous exhaust rapidly of computer instruction whole air bag, lower limb decompression
Afterwards, auterial diastole receives the blood from aorta, thus the afterload of heart is mitigated.
The direct target of external counterpulsation effect is to increase venous return, cardiac output, to make organ, tissue blood flow
Perfusion is improved, and the coronary artery blood supply of especially heart is significantly increased, and provides for ischemic patient effective instant
Haemodynamics is supported；Its long-term goal is then chiefly to facilitate the heart, brain offshoot circulation and improves cardio and vascular function.Therefore, body
The haemodynamics response characteristic of the extracorporeal counterpulsation effect important organs such as lower body and the heart, brain, kidney just seems abnormal important, not still
The theoretical foundation of counterpulsation intervention mode, parameter setting and device research and development, and the most important index of evaluation counterpulsation therapeutic effect.
However even to this day, the haemodynamics of patient's body and target internal organs in Real-Time Evaluation external counterpulsation therapeutic intervention
The technology of response characteristic is not yet set up.The technical solution before more than 30 years is still continued to use in clinic, that is, is used and referred to arteries and veins volume wave
Unique evaluation measures as its instant hemodynamic effect.The heart, brain, peripheral artery disease and tissue tiny blood vessels obstacle
Treatment uses duplicate mode and parameter, lacks accuracy and personalization, therefore the benefit of patient often has biggish difference
It is different, while external counterpulsation apparatus design concept also has no substantive breakthrough over nearly more than 30 years.Lack non-intervention, non-invasive body
It is organized in extracorporeal counterpulsation mechanism, the accurate evaluation technology of internal organs blood perfusion is to cause the major technology bottleneck of above-mentioned predicament.
For this purpose, the effective evaluation technology that body haemodynamics responds in external counterpulsation therapeutic intervention, which becomes, to be influenced to work as precursor
Extracorporeal counterpulsation therapy and one of the key technology of device development.It only develops in counterpulsation therapeutic intervention, the heart-Brain circlulation arterial tree
It is dry just to design more accurately counterpulsation for blood flow, real-time, the Noninvasive evaluation technology of pulse wave, blood flow redistribution at each position
Preforming technique and device formulate personalized therapeutic scheme according to the specificity, disease and patient individual difference of target internal organs, obtain
Optimal hemodynamic Effects finally effectively improve the Clinical efficacy and safety of external counterpulsation therapy.
Since external counterpulsation therapy is initially and the blood perfusion coronarius to improve myocardial ischemia as main syllabus target
Depend primarily on diastolic blood pressure.It therefore, technically can not real-time monitoring hat when early stage researches and develops external counterpulsation therapy and device
In the case that arteries and veins blood flow changes, designer is used till today as indirect evaluation index and always using blood pressure.Currently, domestic
External counterpulsation therapy and device in outer clinic are increased by the finger arteries and veins volume wave of patient in acquisition therapeutic process using its diastole
Press the ratio (D/S) of wave (D) and contraction wave (S) to determine whether reaching instant hemodynamic effect, i.e. D/S >=1.2 item are recognized
It is on the contrary then need to adjust counterpulsation pressure by medical staff and fill the running parameters such as evacuation time up to reaching to reach curative effect requirement
Above-mentioned requirements.
Although above-mentioned technical proposal is simple, convenient and noninvasive, especially it is preced in the treatment of a variety of ischemic blood vessels diseases
Good result is obtained in the treatment of angina pectoris, and the evaluation method and mark of instant blood flow effect are acted on as external counterpulsation
Standard has been written into associated clinical guideline and Consensus of experts.However, this evaluation method is excessively coarse and general, inaccurately, have non-
Normal significant defect, fails to make most reasonable adjustment to counterpulsation mode and parameter according to disease and patient individual difference, to reach
To optimal clinical Benefit.
Present clinical external counterpulsation therapy is set up for myocardial ischemia, is to improve coronary micro-circulation perfusion
Goal-setting refers to the curative effect evaluation criterion of pulse wave D/S >=1.2, however may can not be optimal according to this evaluation criterion
Promoted cerebral artery, peripheral blood vessel, tiny blood vessels blood perfusion effect, thus generate treatment cerebral arterial thrombosis, diabetes
The optimum curative effect of the diseases such as foot, Fundus oculi artery embolism, sudden deafness.Hong Kong Chinese University is newest research shows that existing comments
Price card is quasi- and counterpulsation parameter fails to reach optimal blood flow of middle cerebral artery perfusion promotion, it is proposed that in the treatment of cerebral arterial thrombosis
The middle 0.02MPa counterpulsation pressure using far below guideline recommendation value (0.03MPa or more).
The D/S value of existing evaluation method is however the arteries and veins of the positions such as the heart, brain, foot based on referring to that pulse wave volume wave calculates
It fights and wave and refers to that pulse waveform has a different, especially when the circulatory system is there are when lesion, patch, therefore refer to arteries and veins
D/S >=1.2 of wave are not meant to that diastolic pressure and blood perfusion at target internal organs can reach promising result, otherwise refer at arteries and veins
It is satisfied that D/S < 1.2 are also not meant to that diastolic pressure and blood perfusion at target internal organs cannot achieve the effect that, this is with patient's
Personal feature (age, height, weight, blood vessel and condition of blood, disease condition etc.) is closely related.Meanwhile high counterpulsation
Pressure is likely to increase the adverse events such as patient skin scratch, back pain, lower-limb deep veins thrombus, carotid-cavernous fistulas
Occurrence risk.
In addition, having, external counterpulsation treatment center is introduced into intervention, non-intervention measuring technique monitors mesh in counterpulsation therapeutic intervention
The clinical research personnel of the blood stream rheology of mark internal organs, U.S. salt lake city university and Du Xie university, Japan is led using right heart
Pipe is inserted into art, radial artery detaining tube, pressure and Doppler blood flow measurement and synchronous left and right ventricles catheterization etc. intervene skill in coronary artery
Art measures blood flow velocity and blood pressure in external counterpulsation therapeutic intervention, however since these technologies are to equipment and measurement people
The requirement of member is very harsh, is invasive to patient, while external counterpulsation therapy is not applied to the serious acute heart substantially at present
Vascular disease's first aid is mainly used in the treatment of chronic cardiovascular and cerebrovascular disease, therefore the haemodynamics measurement side intervened
Method is obviously not suitable for the needs of external counterpulsation clinical application.In addition, either intervention or non-intervention measurement method, can only
The haemodynamics data of some or certain several vascular sites are obtained, the heart-brain-peripheral blood vessel blood flow cannot be systematically assessed
Mechanical response situation and blood flow redistribution characteristic.
It is to combine numerical simulation model that evaluation human body arterial tree entirety hemodynamic situation is more practicable at present
Method, wherein being recognized based on the 1D wave propagation model (one-dimensional model) that pulse wave transfer theory is set up
To be most effective and feasible model.However, one-dimensional model still has significant limitation at present, it is wide in clinic to limit it
General application: entire patient's blood vessel is scanned firstly the need of using Imaging Technologies such as CT, MRI, for carrying out geometrical model
Reconstruction, it is extremely time-consuming and expend；Secondly as existing one-dimensional model is only with the blood flow wave of aorta ascendens inlet
Entrance boundary condition, in diastole since aortic valve is closed, blood flow is almost 0 at aorta ascendens, therefore one-dimensional mould
Type not can reflect the influence that the diastole pressurization wave that external counterpulsation effect generates transmits arterial tree pulse wave, and current is one-dimensional
Model is not suitable for assessing the body haemodynamics responsive status in external counterpulsation therapeutic intervention.
Therefore, in order to solve above-mentioned problems of the prior art, embodiment provides machine in a kind of external counterpulsation treatment
The detection method of body haemodynamics response, it is specific as shown in fig. 1, include the following steps:
Step S100, collect the physiologic information of sampler, and using ultrasonic bedside machine respectively in vitro before counterpulsation treatment and
The blood vessel of the sampler and the status data of blood flow are acquired in external counterpulsation treatment；
Step S200, arterial tree is segmented based on artery Tree-structure Model, and acquires the health for meeting preset requirement
Baseline reference is arranged in each blood vessel segment length and internal diameter data of volunteer, according to the exponential model of artery structure and preset
The geometry solving model of mathematical model building patient's arterial tree；
Step S300, setting solves boundary condition, amendment and calibration condition, and is based on the arterial tree geometrical model, institute
Boundary condition and amendment and calibration condition are stated, shape is transmitted to the pulse wave of arterial tree based on pulse wave transfer theory and computation model
Condition and pulse wave, which are distributed, carries out numerical solution, the blood flow arteries and veins of each vessel segment of arterial tree before acquisition external counterpulsation treatment and in treatment
It fights and involves pressure pulse wave；
Step S400, using before the external counterpulsation treatment and treatment in arterial tree each position pulse wave calculated result,
The blood perfusion situation and blood pressure conditions for calculating analysis target blood section position, target internal organs are formed external by comparative analysis
The real-time hemodynamic effect appraisal report of counterpulsation treatment.
Specifically, the present embodiment is first to the physiologic information for collecting sampler, comprising: the height information of the sampler,
Weight information, gender information and age information.And also using ultrasonic bedside machine respectively in vitro before counterpulsation and external counterpulsation
The blood vessel of the sampler and the status data of blood flow are acquired in treating, the blood vessel of the sampler and blood flow
Status data includes: total artery, aorta ascendens, the blood flow velocity of arteria brachialis and the frequency of the left and right side neck of the sampler
Spectrum, vessel diameter data.When the sampler is Disease, then oversleeve type blood pressure measuring device is utilized, the sampling is measured
The systolic pressure and diastolic pressure of the artery position of person.
Further, human body artery is divided into upper layer artery and lower layer's artery, which is aorta, lower layer's artery
For peripheral arterial, secondary lower layer's artery is acra parteriole.Upper layer artery and lower layer's arteriogenesis one huge branch vessel net
Network, specifically as shown in the A figure in Fig. 2.Due to human body artery length and caliber with factors such as height, weight, gender, ages and
Difference, and influenced by pathological factor.By artery Tree-structure Model, (the artery Tree-structure Model is created by Olufsen et al.
Artery Tree-structure Model) arterial tree is divided into 26 sections, as shown in B figure and Fig. 3 in Fig. 2, the aortic length of human body
Depend primarily on height, and the length of each section vessel segment also with individual character such as gender, age, weight, disease condition etc. because
It is known as pass, therefore it is proposed that as follows at the computation model of Human Aortic's length:
Li=k1ik2iL0i, i=1,25
Wherein, L is the length of individual vessel segment；L0For the standard value of blood vessel segment length, it is 170cm left that we, which select height,
Right healthy volunteer person is as reference；k1For the influence coefficient for considering individual height, k1∈[0.8,1.2]； k2It is a to consider
The influence coefficient of body other factors, k2The length of ∈ [0.9,1.0], specific different blood vessel section are as shown in table 1 below, the present embodiment
It is middle to utilize the healthy volunteer that heart arter blood vessel Enhanced CT meets age requirement, height requires and physical condition requires
System vascular, take its average value as L0Reference value.Such as using 3 ages of heart arter blood vessel Enhanced CT 25
Or so year, the system vascular of the healthy volunteer of 170~175cm of height.
Table 1
Since arteries is tapered along its length, tapered form of tubes, therefore described using exponential model
Conical blood vessel internal diameter becomes:
Wherein, rtop、rbotIt is the radius of proximal part and distal end respectively, L is the length of vessel segment.
For bifurcation, the vessel radius of main pipe and two sub- pipes can be indicated with following approximately linear equation:
(r0)d1=α (r0)pa,(r0)d2=β (r0)pa
Wherein, (r0)pa,(r0)d1,(r0)d2The respectively radius of main pipe, sub- pipe 1 and sub- pipe 2；α, β are asymmetry parameter,
0.9 and 0.6 is taken respectively.For there is n for the blood vessel (as shown in Figure 3) of branch, radius change can be described with following equation:
(r0)k,n=αkβn-kr0
The present embodiment utilizes ultrasonic bedside machine measurement patient (i.e. sampler is confirmed as illness) arteria carotis, arteria brachialis and stock
The vessel diameter at three positions of artery, and then entrance, the exit radius of above-mentioned model calculating arterial tree each section vessel segment are combined,
Specifically as shown in figure subscript 2.3 physical condition satisfactory (ages of heart arter blood vessel Enhanced CT are utilized simultaneously
At 25 years old or so, 170~175cm of height) healthy volunteer system vascular internal diameter, take its average value as normal adults
Baseline reference.
Table 2
Further, in this embodiment regard vascular wall as impermeable, ignore gravity influence, blood vessel it is longitudinally constrained.
Under above-mentioned hypothesis, main artery blood flow movement Ke Na Wei-Stokes (Navier-Stokes) equation and its variation are to retouch
It states:
Continuity equation:
The equation of momentum of conservation form:
Wherein, p [Pa] is blood pressure, q [m3] it is blood flow, z [m] is abscissa, and t [s] is time, A [m2] it is that blood vessel is transversal
Face area, C [m2·P·a-1 ]For vascular compliance, ρ [kgm-3] it is density of blood, a [m] is blood vessel inside radius, kinematic viscosity
ν=1.046cm2.A and C0It is calculate by the following formula:
A (z, t)=A0+C0(p-p0)
Wherein μ is Poisson's ratio, a0[m] is the vessel radius under benchmark pressure, and h [m] is wall thickness, and E [Pa] is Young's modulus.
E, h and a0Relationship can be calculated with the empirical equation of Olufsen:
Each fitting parameter is respectively as follows:
k1=2.0 × 106[kg/(m·s2)],
k2=-2.253 × 103[m-1],
k3=8.65 × 104[kg/(m·s2)]
Perimeter strip is arranged in the blood flow wave of the aorta ascendens of the present embodiment combination sampler, arteria carotis communis and arteria brachialis
Part, amendment and calibration condition；Blood in external counterpulsation effect is calculated in conjunction with aorta ascendens, arteria carotis communis and arteria brachialis blood flow wave
Hydromechanics parameter.One-dimensional model is exported using aortic valve, the flow waves at aorta ascendens position is entrance boundary conditions, with
The impedance of parteriole and vein is as export boundary condition.For export boundary condition, continues to use existing pulse wave transmitting and calculate
Method and model calculate the impedance value of exit site.For entrance boundary condition, existing pulse wave TRANSFER MODEL is with a liter active
The flow waves of arteries and veins cause existing pulse wave TRANSFER MODEL to be not suitable for calculating in vitro as unique entrance boundary condition
The active situation of counterpulsation.The blood flow at aorta ascendens position is influenced by aortic valve opening and closing, in diastole due to valve
Film is closed, and the blood flow at this period aorta ascendens is 0 or close to 0.For external counterpulsation Intervention Therapy, main function machine
System is to increase the blood perfusion of upper part of the body important organ by increasing the diastole perfusion pressure of returned blood volume, raising arterial system
Reduce systolic pressure simultaneously, most important influence is to generate diastole pressurization wave, and then increases arterial tree system and important dirty
The blood perfusion of device is horizontal.It therefore, will if still continuing to use original pulse wave transmitting computation model boundary condition set-up mode
It can not reflect that counterpulsation acts on the influence to pulse wave, realize and evaluate external counterpulsation therapeutic intervention blood using pulse wave TRANSFER MODEL
The purpose of hydromechanics effect.
And the present invention due to consideration that external counterpulsation effect it is more significant to the pulse wave action at arteria carotis and arteria brachialis,
The two positions belong to shallow-layer blood vessel simultaneously, and supersonic blood measurement is relatively easy to realize, therefore the invention patent proposes to tie
Aorta ascendens, arteria carotis communis and arteria brachialis blood flow wave are closed to calculate the new think of of the pulse wave in external counterpulsation therapeutic intervention
Road.Involve pulse wave transmitting computation model first with the aorta ascendens blood flow of measurement and calculating to calculate before counterpulsation is treated and treat
In arterial tree flow pulse involve pressure pulse wave；It is right and then by measurement and the arteria carotis communis calculated, brachial artery flow wave
Arterial tree flow waves in counterpulsation intervention are modified and calibrate with pressure wave, by adjusting the entrance boundary item in counterpulsation intervention
Part makes the blood flow wave waveform of arteria carotis communis and arteria brachialis position and total flow calculated value and measured value reach error permission
Range, then it is assumed that the calculated result of arterial tree flow pulse wave elsewhere and pressure pulse wave reaches requirement at this time.
The present invention solves in external counterpulsation treatment, lacks practicable technology and responds shape to body entirety haemodynamics
Condition and target blood and internal organs blood perfusion situation carry out the limitation of effective evaluation, are directed to the heart, brain and peripheral blood vessel disease for development
Sick difference, and important foundation is laid for the precision external counterpulsation Intervention Therapy of individual difference, while being also to develop more
Targetedly intelligence external counterpulsation apparatus lays important foundation, to significantly improve the clinic of external counterpulsation therapy and device
Benefit.
Based on the above embodiment, the present invention also provides the inspections that body haemodynamics in a kind of external counterpulsation treatment responds
Device is surveyed, functional block diagram can be as shown in Figure 4.The device includes: data collection module 410, model construction module 420, mould
Type solves module 430, model evaluation module 440.
Specifically, data collection module 410, for collecting the physiologic information of sampler, and using ultrasonic bedside machine difference
The blood vessel and blood flow state data of the sampler are acquired before counterpulsation treatment and in external counterpulsation treatment in vitro；
Model construction module 420, for being segmented to arterial tree based on artery Tree-structure Model, and acquire meet it is default
It is required that healthy volunteer each blood vessel segment length and internal diameter data, be arranged baseline reference, according to the index mould of artery structure
The geometry solving model of type and preset mathematical model building patient's arterial tree；
Model solution module 430 for amendment and the calibration condition of boundary condition, solution to be arranged, and is based on the boundary
Condition, the amendment of solution and calibration condition and the arterial tree geometrical model, utilize pulse wave transfer theory and 1D wave
Propagation model carry out arterial tree system pulse wave transmitting solution, obtain external counterpulsation treatment before and treatment in patient
The blood flow and blood pressure pulse wave at each position of body arterial tree, the solving result is for assessing target internal organs blood perfusion effect.
Model evaluation module 440, for the arteries and veins using arterial tree each position before the external counterpulsation treatment and in treatment
It fights wave calculated result, calculates and analyze each blood vessel significant points, the blood perfusion situation of target internal organs and blood pressure conditions, pass through comparison
Analysis, forms the real-time hemodynamic effect appraisal report of external counterpulsation treatment.
Preferably, the data collection module 410 in the present embodiment, is also used to: for the sampler, utilizing oversleeve
Formula blood pressure measuring device measures the systolic pressure and diastolic pressure of the arteria brachialis of the sampler.
Preferably, the model construction module 420 in the present embodiment includes: the first submodule, utilizes blood vessel enhanced CT
Technology scans the system vascular that several examples meet age requirement, the healthy volunteer that height requires and physical condition requires, obtains
Take geological information；Heart circulatory system artery is divided into 26 sections using artery Tree-structure Model；Utilize the flat of enhanced CT measurement data
Mean value and arterial tree model establish the baseline model of human body heart circulation arterial system.Second submodule, according to preset artery segment
Geometry teaching model calculates the length of each section of artery of patient using the baseline model of arterial system and the individual information of patient.The
Three submodules measure arteria carotis communis, aorta ascendens, arteria brachialis and the femoral artery of patient using color ultrasound technology and ultrasonic bedside machine
Internal diameter, in this, as amendment and calibration condition, and combine artery structure exponential model and preset mathematical model, calculate suffer from
The inlet radius and exit radius of each section of artery of person.
Preferably, the model solution module 430 in the present embodiment includes: entrance boundary condition setting submodule, for benefit
The solution boundary transmitted with the blood flow wave setting pulse wave of the aorta ascendens before sampler's external counterpulsation treatment and in treatment
Condition；Submodule is arranged in export boundary condition, for utilizing the brachial arterial pressure before sampler's external counterpulsation treatment and in treatment
Measurement data, using the export boundary condition of general lumped parameter calculation method computation model；Model computational submodule, is used for
In conjunction with one-dimensional pulse wave transfer theory and 1D wave propagation model calculate arterial tree each position blood flow pulse wave and
Pressure pulse wave；Modifying model and calibration module, for the blood flow wave measurement data using arteria carotis communis and arteria brachialis, to above-mentioned
The pulse wave calculated result of arterial tree is modified and calibrates, until result and amendment and calibration condition phase that model is calculated
It coincide, i.e., overall flow error is not more than 10%, and waveform maximum disparity is not more than 10%.
Preferably, the model evaluation module 440 in the present embodiment include: blood perfusion evaluation submodule, for calculate and
The blood perfusion in counterpulsation therapeutic intervention is horizontal in vitro and blood flow for the important organs such as evaluation goal vessel segment and the heart, brain, kidney, lung
Redistribution characteristic；Blood pressure evaluates submodule, for calculating and the important organs such as evaluation goal vessel segment and the heart, brain, kidney, lung in body
The variation characteristic of blood pressure level especially diastolic pressure in extracorporeal counterpulsation therapeutic intervention.
Preferably, the device in the present embodiment can be intelligent terminal, above-described embodiment can be realized by the intelligent terminal
Method and step, realization the target in video image is identified and is positioned.Preferably, the memory of the intelligent terminal includes
Non-volatile memory medium, built-in storage.The non-volatile memory medium is stored with operating device and computer program.The memory
Reservoir provides environment for the operation of operating device and computer program in non-volatile memory medium.The intelligent terminal, including
Memory and processor are stored with computer program in memory, which at least may be implemented when executing computer program
Following steps:
The physiologic information of sampler is collected, and using before ultrasonic bedside machine difference in vitro counterpulsation therapeutic intervention and external anti-
It fights and the blood vessel of the sampler and the status data of blood flow is acquired in therapeutic intervention；
Arterial tree is segmented based on artery Tree-structure Model, and acquires each of the healthy volunteer for meeting preset requirement
Baseline reference is arranged, according to the exponential model of artery structure and preset mathematical model structure in blood vessel segment length and internal diameter data
Build the geometry solving model of patient's arterial tree；
Setting solves boundary condition, amendment and calibration condition, and is based on the arterial tree geometrical model, the boundary condition
And amendment and calibration condition, situation and pulse wave are transmitted based on the pulse wave of pulse wave transfer theory and computation model to arterial tree
It is distributed and carries out numerical solution, the blood flow pulse of each vessel segment of arterial tree before acquisition external counterpulsation treatment and in treatment involves pressure
Pulse wave；
Using before the external counterpulsation treatment and treatment in arterial tree each position pulse wave calculated result, calculate analysis mesh
Mark vessel segment position, the blood perfusion situation of target internal organs and blood pressure conditions form external counterpulsation treatment by comparative analysis
Real-time hemodynamic effect appraisal report.
In conclusion the invention discloses the detection methods and dress of body haemodynamics response in external counterpulsation treatment
It sets, the detection method includes: to collect the physiologic information of sampler, and counterpulsation treats preceding and external counterpulsation treatment in vitro respectively
In the blood vessel of sampler and the status data of blood flow are acquired；Based on the structural segmented method of Olufsen arterial tree to dynamic
Arteries and veins tree is segmented, and acquires each blood vessel segment length and internal diameter data for meeting the healthy volunteer of preset requirement, and baseline is arranged
Reference value calculates and constructs the arterial tree geometrical model of patient；According to the boundary condition of ultrasonic measurement result setting solution and repair
Just with calibration condition, and then pressure is involved based on the blood flow pulse that pulse wave transfer theory and solving model calculate each position of arterial tree
The distribution of power pulse wave, and calculate before external counterpulsation treatment accordingly and the blood perfusion and blood of target blood section and internal organs in treatment
Voltage levels.The present invention, which solves in current external counterpulsation therapy, to be lacked for target blood section and the instant haemodynamics of internal organs
The defect of the quick detection and assessment technique of response is expected to the intelligent hair of the precision of counterpulsation Intervention Therapy in vitro and device
It plays a role in exhibition.
It should be understood that the application of the present invention is not limited to the above for those of ordinary skills can
With improvement or transformation based on the above description, all these modifications and variations all should belong to the guarantor of appended claims of the present invention
Protect range.
Claims (10)
1. the detection method that body haemodynamics responds in a kind of external counterpulsation treatment, which is characterized in that the described method includes:
The physiologic information of sampler is collected, and using dry with external counterpulsation before ultrasonic bedside machine difference in vitro counterpulsation therapeutic intervention
The blood vessel of the sampler and the status data of blood flow are acquired in pretreatment；
Arterial tree is segmented based on artery Tree-structure Model, and acquires each blood vessel for meeting the healthy volunteer of preset requirement
Baseline reference is arranged in segment length and internal diameter data, is suffered from according to the exponential model of artery structure and the building of preset mathematical model
The geometry solving model of person's arterial tree；
Setting solves boundary condition, amendment and calibration condition, and based on the arterial tree geometrical model, the boundary condition and repairs
Just with calibration condition, based on pulse wave transfer theory and computation model transmits situation to the pulse wave of arterial tree and pulse wave is distributed
Numerical solution is carried out, the blood flow pulse of each vessel segment of arterial tree before external counterpulsation treatment and in treatment is obtained and involves pressure pulse
Wave；
Using before the external counterpulsation treatment and treatment in arterial tree each position pulse wave calculated result, calculate analysis target blood
Pipeline section position, the blood perfusion situation of target internal organs and blood pressure conditions form the real-time of external counterpulsation treatment by comparative analysis
Hemodynamic effect appraisal report.
2. the detection method that body haemodynamics responds in external counterpulsation treatment according to claim 1, feature exist
In the physiologic information includes: the height information of the sampler, weight information, gender information, age information and health letter
Breath.
3. the detection method that body haemodynamics responds in external counterpulsation treatment according to claim 1, feature exist
In the blood vessel of the sampler and the status data of blood flow include: total artery, the liter of the left and right side neck of the sampler
Aorta, the blood flow velocity of arteria brachialis and frequency spectrum, vessel diameter data.
4. the detection method that body haemodynamics responds in external counterpulsation treatment according to claim 1, feature exist
In, the physiologic information for collecting sampler, and counterpulsation treatment is preceding in vitro respectively and external counterpulsation is controlled using ultrasonic bedside machine
The blood vessel of the sampler and the status data of blood flow are acquired in treatment, further includes:
Oversleeve type blood pressure measuring device is then utilized, the systolic pressure and diastolic pressure of the artery position of sampler are measured.
5. the detection method that body haemodynamics responds in external counterpulsation treatment according to claim 1, feature exist
In, it is described that arterial tree is segmented based on artery Tree-structure Model, and acquire each of the healthy volunteer for meeting preset requirement
Baseline reference is arranged, according to the exponential model of artery structure and preset mathematical model structure in blood vessel segment length and internal diameter data
Build the geometry solving model of patient's arterial tree, comprising:
Artery is divided into upper layer artery and lower layer, secondary lower layer's artery, the upper layer artery and lower layer, secondary lower layer's arteriogenesis branch
Blood vessel network and artery tree construction；
Arterial tree is divided into 26 sections according to artery Tree-structure Model；
Meet the whole body blood of age requirement, the volunteer that height requires and physical condition requires using blood vessel Enhanced CT
Pipe, takes length of vessel average value as baseline reference, establishes patient's artery using preset mathematical model and baseline reference
Set the computation model of each segment length；Using the exponential model of artery structure, preset mathematical model and baseline reference, establishes and suffer from
The internal diameter computation model of person's arterial tree each section.
6. the detection method that body haemodynamics responds in external counterpulsation treatment according to claim 1, feature exist
In the setting solves boundary condition, amendment and calibration condition, and is based on the arterial tree geometrical model, the boundary condition
And amendment and calibration condition, situation and pulse wave are transmitted based on the pulse wave of pulse wave transfer theory and computation model to arterial tree
It is distributed and carries out numerical solution, the blood flow pulse of each vessel segment of arterial tree before acquisition external counterpulsation treatment and in treatment involves pressure
Pulse wave, comprising:
Using the aorta ascendens blood flow wave of sampler, boundary condition is set；Outlet is calculated using the blood pressure measurement of arteria brachialis
Boundary condition；Based on pulse wave transfer theory and 1D wave propagation solving model, and combine arteria carotis communis and the upper arm dynamic
Arteries and veins blood flow wave measurement value setting solve correction conditions and calibration condition, to before external counterpulsation therapeutic intervention and intervene control
Arterial tree pulse wave transmitting situation and pulse wave distribution situation in treatment are solved；
Using before the external counterpulsation treatment and treatment in arterial tree each position pulse wave calculated result, calculate analysis target blood
Pipeline section position, target internal organs blood perfusion is horizontal and blood pressure level, form the real-time hemodynamic of external counterpulsation therapeutic intervention
Learn effect analysis appraisal report.
7. the detection device that body haemodynamics responds in a kind of external counterpulsation treatment, which is characterized in that the detection device
Include:
Data collection module, for collecting the physiologic information of sampler, and using ultrasonic bedside machine, counterpulsation is treated in vitro respectively
The blood vessel and blood flow state data of the sampler are acquired in preceding and external counterpulsation treatment；
Model construction module for being segmented based on artery Tree-structure Model to arterial tree, and is acquired and meets preset requirement
Baseline reference is arranged, according to the exponential model of artery structure and preset mathematical modulo in the vessel diameter data of healthy volunteer
Type constructs arterial tree geometrical model；
Model solution module solves boundary condition, amendment and calibration condition for being arranged, and is based on the arterial tree geometry mould
Type, the boundary condition and amendment and calibration condition, based on pulse wave transfer theory and computation model to the pulse wave of arterial tree
Transmitting situation and pulse wave, which are distributed, carries out numerical solution, each vessel segment of arterial tree before acquisition external counterpulsation treatment and in treatment
Blood flow pulse involves pressure pulse wave；
Model evaluation module, for using the pulse wave of arterial tree each position calculates knot before the external counterpulsation treatment and in treatment
Fruit calculates the blood perfusion situation and blood pressure conditions at analysis target blood section position, target internal organs, by comparative analysis, is formed
The real-time hemodynamic effect appraisal report of external counterpulsation treatment.
8. the detection device of the body haemodynamics response characteristic in external counterpulsation treatment according to claim 7,
It is characterized in that, the model construction module includes:
First submodule scans several examples and meets age requirement, height requirement and body for utilizing blood vessel enhanced CT technology
The system vascular for the volunteer that situation requires obtains geological information；Heart circulatory system artery is divided using artery Tree-structure Model
It is 26 sections；Using the average value and arterial tree segmentation method of enhanced CT measurement data, the base of human body heart circulation arterial system is established
Line model；
Second submodule utilizes the baseline model of arterial system and the individual of patient for calculating mathematical model according to artery segment
Information calculates the length of each section of artery of patient；
Third submodule, for using color ultrasound technology and ultrasonic bedside machine, the arteria carotis communis, aorta ascendens, the upper arm for measuring patient to be dynamic
The internal diameter of arteries and veins and femoral artery in this, as amendment and calibration condition, and combines the exponential model and preset mathematics of artery structure
Model calculates the inlet radius and exit radius of each section of artery of patient.
9. the detection device that body haemodynamics responds in external counterpulsation treatment according to claim 7, feature exist
In the model solution module includes:
Entrance boundary condition setting submodule, for the blood using the aorta ascendens before sampler's external counterpulsation treatment and in treatment
The solution boundary condition that pulse wave transmits is arranged in flow quantity wave；
Submodule is arranged in export boundary condition, for being surveyed using the brachial arterial pressure before sampler's external counterpulsation treatment and in treatment
Data are measured, using the export boundary condition of general lumped parameter calculation method computation model；
Model computational submodule, for combining one-dimensional pulse wave transfer theory and 1D wave propagation model to calculate body
Extracorporeal counterpulsation treats the blood flow pulse wave and pressure pulse wave of arterial tree each position in preceding and treatment；
Modifying model and calibration module, for the blood flow wave measurement data using arteria carotis communis and arteria brachialis, to above-mentioned arterial tree
Pulse wave calculated result be modified and calibrate, until the result that is calculated of model is matched with calibration condition with correcting,
I.e. overall flow error is not more than 10%, and waveform maximum disparity is not more than 10%.
10. the detection device that body haemodynamics responds in external counterpulsation treatment according to claim 7, feature exist
In the model evaluation module includes:
Blood perfusion evaluates submodule, is used for calculating and the important organs such as evaluation goal vessel segment and the heart, brain, kidney, lung in vitro
Blood perfusion level and blood flow redistribution characteristic in counterpulsation therapeutic intervention；
Blood pressure evaluates submodule, is used for calculating and the important organs such as evaluation goal vessel segment and the heart, brain, kidney, lung counterpulsation in vitro
The variation characteristic of blood pressure level especially diastolic pressure in therapeutic intervention.
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| CN113018135A (en) * | 2021-02-24 | 2021-06-25 | 山东交通学院 | External counterpulsation cooperative control system and method |
| CN113018135B (en) * | 2021-02-24 | 2023-01-31 | 山东交通学院 | External counterpulsation cooperative control system and method |
| CN113040728A (en) * | 2021-03-08 | 2021-06-29 | 北京工业大学 | Personalized evaluation method for long-term hemodynamics effect of external counterpulsation |
| CN113040728B (en) * | 2021-03-08 | 2023-09-26 | 北京工业大学 | Establishment method of personalized in-vitro counterpulsation long-term hemodynamic effect personalized evaluation model |
| CN115040100A (en) * | 2022-06-14 | 2022-09-13 | 安影科技（北京）有限公司 | Method for rapidly acquiring optic nerve blood flow perfusion value |
| CN115040100B (en) * | 2022-06-14 | 2023-10-27 | 安影科技（北京）有限公司 | Rapid acquisition method for optic nerve blood flow perfusion numerical value |
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