CN110376256B - Sensor based on nanowire array and suitable for colony cell particle detection and detection method using sensor - Google Patents
Sensor based on nanowire array and suitable for colony cell particle detection and detection method using sensor Download PDFInfo
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Abstract
The invention provides a sensor based on a nanowire array and suitable for colony cell particle detection, which comprises: a nanowire array formed by a plurality of nanowires; two ends of each nanowire are respectively and electrically connected to a first leading-out end and a second leading-out end; the first leading-out terminal and the second leading-out terminal are used for being electrically connected to the signal processing terminal. The distance between each nanowire and the adjacent nanowire forming the nanowire array is smaller than the size of an object to be detected, and the nanowires can be modified with sites which are specifically combined with the object to be detected. Correspondingly, a detection method based on the sensor is also provided, and comprises the following steps: capturing an object under test using the nanowire array of the sensor; and obtaining the change of the electric signals by the signal processing end, and determining the quantity and concentration data of the measured object according to the change of the electric signals. The sensor with the structure can realize the detection of bacterial colonies, cells or the measured object of micron-sized particles.
Description
Technical Field
The invention relates to a detection technology, in particular to a sensor based on a nanowire array and suitable for colony cell particle detection and a detection method using the sensor.
Background
At present, based on the nanowire array detection technology, a working electrode of a detector is mostly decorated with a nanopillar protruding outwards from the surface to form a nanowire array. For example:
the chinese patent application No. CN201410288286.8 discloses a technique for growing a titanium dioxide nanowire array on an FTO-containing conductive glass substrate, wherein a titanium dioxide nanowire array is grown on an electrode, and a specific receptor modification of a molecule to be detected is performed on the surface of a nanoparticle, when the specific receptor is combined with the molecule to be detected, the field intensity on the surface of the nanoparticle changes, the electron transmission efficiency between the interface of the nanoparticle and titanium oxide changes, so that the output electrical signal reflects the process, and high-sensitivity detection of the substance to be detected is realized.
For another example, the patent application with the chinese patent application No. CN201210173858.9 discloses a periodontal bacteria impedance immunosensor based on conductive polymer, in which a nanowire array is modified on the surface of a working microelectrode to increase the fixed number of antibodies per unit area and the specific detection surface area, thereby greatly improving the sensitivity, anti-interference performance, and response time of the sensor.
The basic principle is the same as the working principle of the sensor, and the working electrode captures the measured object, so that the output electric signal of the electrode changes to detect. The nanowire array has the main function of improving the sensitivity, and specifically has the following functions:
the surface of a working electrode of the existing sensor is modified with a columnar nanowire array, so that the detection specific surface area of the working electrode can be increased structurally, and the detection sensitivity is improved; on the other hand, the working electrode is easier to capture strains and cells through the columnar nanowire array, and the detection sensitivity is improved.
The invention provides a sensor which is based on a nanowire array and is suitable for colony cell particle detection and a detection method using the sensor.
Disclosure of Invention
In view of the above, the main objective of the present invention is to provide a sensor based on a nanowire array and suitable for detecting colony cell particles, and a detection method using the sensor, which have different structures from those in the background art, and can also realize the detection of the object to be detected.
The invention provides a sensor suitable for colony cell particle detection based on a nanowire array, which comprises:
a nanowire array formed by a plurality of nanowires;
two ends of each nanowire are respectively and electrically connected to a first leading-out end and a second leading-out end;
the first leading-out terminal and the second leading-out terminal are used for being electrically connected to the signal processing terminal.
Therefore, the nano-wire with the nanoscale line width is adopted, so that the nano-wire has ultrahigh current density when being used for detecting the electrical index, and further generates a stronger electrical response signal, and the quantity and concentration detection of the measured object with the size of equal microns and very small concentration can be realized. Moreover, the nano-scale wire array can be applied to electrochemical sensors, resistance type, impedance type, resonance type and optical sensors, and two ends of the wire array can be electrically connected to the leading-out terminals and then connected to the corresponding signal processing terminals according to requirements so as to amplify, sample and analyze signals.
The nanowires forming the nanowire array are arranged in parallel, and the wire distance between adjacent nanowires is 1nm-5000nm and is smaller than the size of an object to be measured.
By last, this interval is to the corresponding setting of testee size, makes this line interval slightly be lighter than the testee size, can make even only single colony, cell or micron size particulate matter's testee in the testee fall on nanowire array, also can be caught by at least one nano wire.
Wherein, the nano-wire is modified with a site which is specifically combined with the object to be detected.
Thus, the nanowires can be specifically and firmly bound to the encountered analyte through the sites, so that the binding is firm after the capture.
The first leading-out end and the second leading-out end are linear structures of wires, and the nanowire array is decorated between the two wires.
The first leading-out end and the second leading-out end are in opposite electrode plate-shaped structures, and the nanowire array is decorated between the two electrode plates.
Therefore, different structures can be arranged, the leading-out end can exist in a wire mode or a plate mode, and the corresponding nanowire arrays can exist in the same plane or in a three-dimensional mode so as to adapt to different detection requirements or detection application scenes.
The first leading-out end and the second leading-out end are respectively provided with a contact array formed by a plurality of contacts which are not electrically connected with each other; at least one nanowire is connected between one contact of the first leading-out end and one contact of the second leading-out end; the contact arrays of the first leading-out end and the second leading-out end lead out electric connection wires respectively so as to electrically connect the multi-path electric signals to the signal processing end.
Adopt multichannel signal, after catching a bacterial colony cell, the signal of telecommunication of the change of corresponding contact is detected by the processor module in the signal processing end, and the signal of adjacent other contacts then can not change or the change that produces is less to can be according to the position of corresponding contact and tentatively judge the position of bacterial colony cell. Furthermore, when a plurality of colony cells are captured by different nanowires, the processor module can preliminarily judge the position of each colony cell according to the electric signal change of the corresponding contact, so that subsequent further analysis is facilitated.
The invention further provides a detection method using the sensor suitable for colony cell particle detection based on the nanowire array, which comprises the following steps:
capturing an object under test using the nanowire array of the sensor;
and obtaining the electric signal change by the signal processing end.
Thus, the present invention can be used to detect an analyte, such as a colony, a cell, or a micron-sized particulate.
And determining the quantity and/or concentration of the measured object according to the change of the electric signal.
From the above, the amount and concentration of the analyte can be detected accordingly.
When the signal processing end collects the multiple paths of electric signals, the position of the detected object on the nanowire array is determined according to the change of each path of electric signal.
Therefore, the position of the detected object captured on the nanowire array can be detected according to the method, and further analysis is facilitated.
Wherein, still include: the nano-wires are modified with a binding substance with the fluorescence characteristic specificity of the measured object, and the quantity, the concentration and/or the position of the measured object on the nano-wire array are determined according to the fluorescence change generated when the measured object is captured by the sensor; or
The nanowires are decorated with a material that causes the nanowires to have fluorescence, and the quantity, concentration and/or position of the analyte on the nanowire array is determined according to changes caused by blocking fluorescence when the analyte is captured by the sensor.
From the above, the fluorescence properties can be further combined to observe the amount, concentration and/or location of the analyte on the nanowire array.
Drawings
FIG. 1 is a schematic structural diagram of a first embodiment of a sensor adapted for colony cell particle detection based on a nanowire array;
FIG. 2 is a schematic structural diagram of a second embodiment of a sensor suitable for colony cell particle detection based on a nanowire array;
FIG. 3 is a schematic structural diagram of a third embodiment of a sensor suitable for colony cell particle detection based on a nanowire array;
FIG. 4 is a schematic structural diagram of a fourth embodiment of a sensor suitable for colony cell particle detection based on a nanowire array.
Detailed Description
The invention has the innovation point that the linear array structure is used for detecting the quantity and the concentration of the cell colony equal-micron-size detected object. When the line arrays are parallel, the distance between adjacent lines of the line array structure is 1nm-5000nm, the distance can be correspondingly set according to the size of a measured object, the distance between the lines is slightly smaller than the size of the measured object, and even if the measured object with only a single colony, cell or micron-sized particle falls onto the nanowire array, the measured object can be captured by at least one nanowire. Moreover, the nanowire can be modified with a site specifically binding to the detected object, and can be specifically and firmly bound with the encountered detected object, so that the binding is firm after the capture. The nano-wire with the nano-scale line width is adopted, so that the nano-wire has ultrahigh current density when being used for detecting an electrical index, and further generates a stronger electrical response signal, and the quantity and the concentration detection of the detected object with the small concentration and the same micron size can be realized.
The nano-scale linear array can be applied to electrochemical sensors, and can also be applied to resistive, impedance, resonant and optical sensors. According to different structures (see the embodiments described later), the terminals can exist in a wire mode and a plate mode, and the terminals can lead signals to the signal processing terminal so as to amplify, sample, analyze and the like the signals.
Fig. 1 shows a first embodiment of the sensor suitable for colony cell particle detection based on a nanowire array according to the present invention, wherein the sensor comprises a nanowire array composed of a plurality of linear nanowires, and two ends of each nanowire are electrically connected to a first and a second extraction terminal respectively.
As shown in fig. 1, the sensor is a structural schematic diagram of the sensor existing in a sheet manner, the first and second terminals exist in a linear structure of a wire, and the nanowire array, the first and second terminals are located in a plane.
As shown in fig. 2, the sensor is a schematic structural diagram existing in a three-dimensional manner, when the sensor exists in a three-dimensional manner, the first and second terminals exist in a plate-shaped structure of opposite electrodes, and the nanowire array is decorated between the two electrode plates to form a three-dimensional form as a whole.
In the two embodiments, the first lead-out terminal and the second lead-out terminal are respectively connected to the signal processing terminal so as to amplify the electric signal and then perform analysis and other processing. And the processor module in the signal processing terminal realizes detection according to the collected electric signal change between the first leading-out terminal and the second leading-out terminal. The principle is as follows: the nanowire array of the sensor captures colony cells, and causes a change in an electrical signal between the first and second terminals, which is detected by the processor module at the signal processing terminal.
Fig. 3 shows a further embodiment of the invention, which is a further development based on the embodiment shown in fig. 1, and is described in more detail below:
as shown in fig. 3, in this example, the first terminal has a plurality of contacts (7 contacts of the first terminal are shown) that are not electrically connected to each other, forming a contact array; the corresponding second terminals also have a plurality of contacts that are not electrically connected to each other and form an array. And a contact of the first leading-out end is modified to form at least one nanowire connected to a contact of the second leading-out end so as to form the connection of the nanowires between the two contacts. The contact arrays of the first leading-out end and the second leading-out end lead out electric connection wires respectively so as to provide multi-path signals to the signal processing end.
It is understood that based on the principle of the embodiment shown in fig. 3, the embodiment shown in fig. 2 may also be used as a basis, and the contact arrays are disposed on the two electrode plates, which are not described again.
The advantage of this kind of multichannel signal output lies in, after catching a bacterial colony cell, the signal processor module in the signal processing end of the change of corresponding contact detects, and the signal processor module in adjacent other contacts then can not change or the change that produces is less, and processor module can be based on the position of corresponding contact preliminary judgement bacterial colony cell's position like this. Furthermore, when a plurality of colony cells are captured by different nanowires, the processor module can preliminarily judge the position of each colony cell according to the electric signal change of the corresponding contact, so that subsequent further analysis is facilitated.
It can be seen from the above embodiments that the present invention adopts another structure to implement a sensor based on a nanowire array and suitable for colony cell particle detection, which is different from the sensor based on a nanowire array in the background art.
It should also be noted that the wire arrays shown in figures 1, 2 and 3 of the present invention are schematic and thus appear to be equally spaced, parallel. In practice, the modified wire arrays are not equally spaced, parallel as shown, as illustrated in the following:
corresponding to fig. 1 and 2, the modified wire array is connected to two terminals.
Corresponding to the embodiment shown in fig. 3, during modification, the nanowire connected with the two contacts is modified from the contact on one leading-out terminal to the contact on the other leading-out terminal; also, as shown in contact 2 in the embodiment shown in fig. 4, on a pair of contacts, a plurality of nanowires may be trimmed; also, there are nanowires connected from one contact of one terminal to multiple contacts of another terminal, as shown by contact 3 in fig. 4, and these are all applicable to the present invention.
For the planar nanowire array sensor as shown in fig. 1, 3 or 4, the nanowire array can be formed by nanoimprint method or screen printing method, and then electrically connected first and second terminals are disposed on two sides. For the three-dimensional form shown in fig. 2, the three-dimensional form may be constructed by first forming sheets as above and then stacking the sheets to form a plurality of sheets.
In addition, the nanowires of the invention can be modified with a binding substance specific to the fluorescence characteristic of the measured object, and the measured object can emit fluorescence after being captured, so that the quantity, concentration and/or position of the measured object on the nanowire array can be determined according to the change of the fluorescence generated when the sensor captures the measured object. In another embodiment, the nanowires are decorated with a material that renders the nanowires fluorescent, and when an analyte is captured, the location of the analyte blocks the fluorescence of the nanowires, so that the amount, concentration, and/or location of the analyte on the nanowire array can be determined based on the change in the blocked fluorescence of the analyte captured by the sensor.
The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents, improvements and the like that fall within the spirit and principle of the present invention are intended to be included therein.
Claims (2)
1. A sensor adapted for colony cell particle detection based on an array of nanowires, comprising:
the nano-wire array is composed of a plurality of nano-wires, all the nano-wires forming the nano-wire array are arranged in parallel, and the wire spacing between adjacent nano-wires is 1nm-5000nm and is smaller than the size of an object to be measured;
the two ends of each nanowire are respectively and electrically connected to a first leading-out end and a second leading-out end, the first leading-out end and the second leading-out end are respectively provided with a contact array formed by a plurality of contacts which are not electrically connected with each other, at least one nanowire is connected between one contact of the first leading-out end and one contact of the second leading-out end, the contact arrays of the first leading-out end and the second leading-out end are respectively provided with an electric connecting wire so as to electrically connect a plurality of paths of electric signals to a signal processing end, the signal processing end determines the position of a measured object on the nanowire array to be captured according to the change of the electric signals of the contacts, and the number and/or the concentration of the measured object is determined according to the change of the electric signals;
the first leading-out end and the second leading-out end are linear structures of wires, and the nanowire array is decorated between the two wires; or the first leading-out end and the second leading-out end are in opposite electrode plate-shaped structures, and the nanowire array is decorated between the two electrode plates;
the nano-wires are modified with a binding substance with the fluorescence characteristic specificity of the measured object and used for determining the number, the concentration and/or the position of the measured object on the nano-wire array according to the fluorescence change generated when the measured object is captured by the sensor; or, the nano-wires are decorated with materials which enable the nano-wires to have fluorescence, and the materials are used for determining the quantity, the concentration and/or the positions of the detected objects on the nano-wire array according to changes caused by shielding fluorescence when the detected objects are captured by the sensor.
2. A method of detection using the nanowire array-based sensor adapted for colony cell particle detection of claim 1, comprising:
capturing an object under test using the nanowire array of the sensor;
obtaining the change of the electric signal by the signal processing end;
determining the quantity and/or concentration of the measured object according to the change of the electric signal;
when the signal processing end collects multiple paths of electric signals, the position of the detected object on the nanowire array is determined according to the change of each path of electric signal;
the nano-wires are modified with a binding substance with the fluorescence characteristic specificity of the measured object, and the quantity, the concentration and/or the position of the measured object on the nano-wire array are determined according to the fluorescence change generated when the measured object is captured by the sensor; or
The nanowires are decorated with a material that causes the nanowires to have fluorescence, and the quantity, concentration and/or position of the analyte on the nanowire array is determined according to changes caused by blocking fluorescence when the analyte is captured by the sensor.
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| CN104089999A (en) * | 2014-06-25 | 2014-10-08 | 复旦大学 | Carbon quantum dot-nanowire array-based cardiomyocyte signal molecule sensor and preparation method thereof |
| CN104697882A (en) * | 2014-09-30 | 2015-06-10 | 北京工业大学 | Mass sensor for ambient air PM (particulate matter)2.5 based on ZnO nanowire array and preparation method for mass sensor |
| CN109632140A (en) * | 2018-12-26 | 2019-04-16 | 天津大学 | A kind of temperature sensor and temperature-detecting device |
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| CN104089999A (en) * | 2014-06-25 | 2014-10-08 | 复旦大学 | Carbon quantum dot-nanowire array-based cardiomyocyte signal molecule sensor and preparation method thereof |
| CN104697882A (en) * | 2014-09-30 | 2015-06-10 | 北京工业大学 | Mass sensor for ambient air PM (particulate matter)2.5 based on ZnO nanowire array and preparation method for mass sensor |
| CN109632140A (en) * | 2018-12-26 | 2019-04-16 | 天津大学 | A kind of temperature sensor and temperature-detecting device |
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