CN110354023A - 一种具有抑菌作用的口腔护理组合物 - Google Patents
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Abstract
本发明公开了一种具有抑菌作用的口腔护理组合物,涉及口腔护理技术领域。该口腔护理组合物包括以下组分:0.05%~5%抑菌粉末;10%~50%摩擦剂;10%~60%保湿剂;0.5%~10%发泡剂;0.2%~2%增稠剂;0.01%~0.5%防腐剂;0.2%~2%香精;余量水;所述抑菌粉末由5%~20%抑菌剂,5%~20%控释剂,60%~90%成型剂组成。本发明通过将杀菌剂与控释剂及成型剂制备成抑菌粉末,加入到牙膏中,一方面能够起到保护杀菌剂不与表面活性剂发生作用,另一方面可以保证抑菌粉末能够在口腔内释放出杀菌剂,起到抑制口腔细菌的作用。
Description
技术领域
本发明涉及口腔护理产品技术领域,尤其涉及一种具有抑菌作用的口腔护理组合物。
背景技术
现代医学研究认为,细菌的存在是口腔疾病发生的先决条件。口腔细菌及其所形成的牙菌斑容易引起口腔问题,如龋齿,牙周病,口臭等。药物防治是目前治疗和预防口腔疾病最有效的方式。牙周炎在发病初期,牙龈肿胀疼痛,妨碍咀嚼,影响进餐,重者可导致患侧的面颊部肿胀。中医理论认为,这是湿热熏蒸所致,宜用清化湿热之药。《本草纲目》记载:金银花和野菊花具有排脓解毒、消肿止痛、疏风热、清头目、降火解毒,治诸风眩晕、头痛、目赤和中毒等功效,尤其是金银花对大多数病原菌都有不同程度的抗菌作用。
一些医学专家认为,即使牙膏中含有一些能够对防治某种病有效的成分,但在实际使用过程中,往往不能获得令人满意的效果。在牙膏中加入药物的方式来治疗口腔疾病,还存在很多障碍。
发明内容
本发明所要解决的技术问题是如何使得功效性药物成分应用于牙膏,且保证药物作用效果,提供一种含抑菌功效的口腔护理组合物。
为了解决上述问题,本发明提出以下技术方案:
一种具有抑菌作用的口腔护理组合物,按质量百分比计,该口腔护理组合物包括以下组分:
0.05%~5%抑菌粉末;
10%~50%摩擦剂;
10%~60%保湿剂;
0.5%~10%发泡剂;
0.2%~2%增稠剂;
0.01%~0.5%防腐剂;
0.2%~2%香精;
余量水;
所述抑菌粉末由5%~20%抑菌剂,5%~20%控释剂,60%~90%成型剂组成。
优选地,该口腔护理组合物包括以下组分:
0.05%~5%抑菌粉末;
15%~40%摩擦剂;
10%~50%保湿剂;
1%~10%发泡剂;
0.2%~2%增稠剂;
0.01%~0.5%防腐剂;
0.2%~2%香精;
余量水。
优选地,该口腔护理组合物包括以下组分:
0.05%~5%抑菌粉末;
20%~40%摩擦剂;
20%~40%保湿剂;
2%~10%发泡剂;
0.2%~2%增稠剂;
0.01%~0.5%防腐剂;
0.2%~2%香精;
余量水。
在一实施例中,所述抑菌剂选自西吡氯铵、氯己定、葡萄酸氯己定、醋酸氯己定、聚六亚甲基胍盐酸盐、二癸基二甲基氯化铵、苯扎氯铵、苯扎溴铵中的一种或多种。
在一实施例中,所述控释剂选自硬脂酸、硬脂酸甘油酯、月桂酸、十三酸、肉豆蔻酸、十五酸、棕榈酸、十七酸、十九酸、花生酸、月桂酸月桂醇酯、棕榈酸肉豆蔻醇酯、硬脂酸月桂醇酯、软酯酸蜂花醇酯、月桂酸甘油酯、单硬酯酸甘油酯、硬脂酸乙二醇酯中的一种或多种。
在一实施例中,所述成型剂选环糊精、纤维素衍生物、壳聚糖、聚乙烯亚胺、聚乙烯醇、羟丙基纤维素和羟乙基的一种或多种。
在一实施例中,所述摩擦剂选自二氧化硅、碳酸钙、磷酸氢钙、微晶纤维素的一种或多种。
在一实施例中,所述保湿剂选自山梨醇、甘油、聚乙二醇、丙二醇的一种或多种。
在一实施例中,所述发泡剂选自十二烷基硫酸酯钠或钾盐、椰油酰胺丙基甜菜碱、月桂酰肌氨酸钠、月桂酰肌氨酸钾、烷基糖苷、月桂醇二乙醇胺中的一种或多种。
进一步地,所述增稠剂选自羧甲基纤维素钠、卡拉胶、黄原胶、瓜尔胶的一种或几多种。
与现有技术相比,本发明所能达到的技术效果包括:本发明通过将杀菌剂与控释剂及成型剂制备成抑菌粉末,加入到牙膏中,一方面能够起到保护杀菌剂不与表面活性剂发生作用,另一方面可以保证抑菌粉末能够在口腔内释放出杀菌剂,起到抑制口腔细菌的作用。
具体实施方式
下面将结合本发明实施例,对实施例中的技术方案进行清楚、完整地描述。显然,以下将描述的实施例仅仅是本发明一部分实施例,而不是全部的实施例。基于本发明中的实施例,本领域普通技术人员在没有作出创造性劳动前提下所获得的所有其他实施例,都属于本发明保护的范围。
应当理解,当在本说明书和所附权利要求书中使用时,术语“包括”和“包含”指示所描述特征、整体、步骤、操作、元素和/或组件的存在,但并不排除一个或多个其它特征、整体、步骤、操作、元素、组件和/或其集合的存在或添加。
还应当理解,在此本发明实施例说明书中所使用的术语仅仅是出于描述特定实施例的目的而并不意在限制本发明实施例。如在本发明实施例说明书和所附权利要求书中所使用的那样,除非上下文清楚地指明其它情况,否则单数形式的“一”、“一个”及“该”意在包括复数形式。
本发明实施例提供一种具有抑菌作用的口腔护理组合物,按质量百分比计,该口腔护理组合物包括以下组分:
0.05%~5%抑菌粉末;
10%~50%摩擦剂;
10%~60%保湿剂;
0.5%~10%发泡剂;
0.2%~2%增稠剂;
0.01%~0.5%防腐剂;
0.2%~2%香精;
余量水;
所述抑菌粉末由5%~20%抑菌剂,5%~20%控释剂,60%~90%成型剂组成。
在其他实施例中,该具有抑菌作用的口腔护理组合物包括以下组分:
0.05%~5%抑菌粉末;
15%~40%摩擦剂;
10%~50%保湿剂;
1%~10%发泡剂;
0.2%~2%增稠剂;
0.01%~0.5%防腐剂;
0.2%~2%香精;
余量水;
所述抑菌粉末由5%~20%抑菌剂,5%~20%控释剂,60%~90%成型剂组成。
在其他实施例中,该具有抑菌作用的口腔护理组合物包括以下组分:
0.05%~5%抑菌粉末;
20%~40%摩擦剂;
20%~40%保湿剂;
2%~10%发泡剂;
0.2%~2%增稠剂;
0.01%~0.5%防腐剂;
0.2%~2%香精;
余量水;
所述抑菌粉末由5%~20%抑菌剂,5%~20%控释剂,60%~90%成型剂组成。抑菌粉末的制备方法为按比例将抑菌剂、控释剂及成型剂进行充分混合,混匀后进行喷雾干燥,制得粉末状的抑菌粉末。由此制得的抑菌粉末能够保护抑菌剂的活性物质。
具体实施中,所述抑菌剂选自西吡氯铵、氯己定、葡萄酸氯己定、醋酸氯己定、聚六亚甲基胍盐酸盐、二癸基二甲基氯化铵、苯扎氯铵、苯扎溴铵中的一种或多种。
具体实施中,所述控释剂选自硬脂酸、硬脂酸甘油酯、月桂酸、十三酸、肉豆蔻酸、十五酸、棕榈酸、十七酸、十九酸、花生酸、月桂酸月桂醇酯、棕榈酸肉豆蔻醇酯、硬脂酸月桂醇酯、软酯酸蜂花醇酯、月桂酸甘油酯、单硬酯酸甘油酯、硬脂酸乙二醇酯中的一种或多种。
具体实施中,所述成型剂选环糊精、纤维素衍生物、壳聚糖、聚乙烯亚胺、聚乙烯醇、羟丙基纤维素和羟乙基的一种或多种。
可以理解,本发明提供的抑菌剂为阳离子杀菌剂,为避免阳离子杀菌剂与牙膏中的表面活性剂发生作用,影响杀菌效果,因此,将抑菌剂与控释剂及成型剂制备成抑菌粉末,加入到牙膏组分中,保证抑菌效果。
具体实施中,所述摩擦剂选自二氧化硅、碳酸钙、磷酸氢钙、微晶纤维素的一种或多种。
具体实施中,所述保湿剂选自山梨醇、甘油、聚乙二醇、丙二醇的一种或多种。
具体实施中,所述发泡剂选自十二烷基硫酸酯钠或钾盐、椰油酰胺丙基甜菜碱、月桂酰肌氨酸钠、月桂酰肌氨酸钾、烷基糖苷、月桂醇二乙醇胺中的一种或多种。
具体实施中,所述增稠剂选自羧甲基纤维素钠、卡拉胶、黄原胶、瓜尔胶的一种或几多种。
实施例1
具有抑菌作用的口腔护理组合物各组分的质量百分比为抑菌粉末4.0%,碳酸钙30.0%,二氧化硅5.0%,山梨醇20.0%,甘油5.0%,聚乙二醇2.0%,纤维素胶0.5%,黄原胶为0.3%,烷基糖苷8.0%,香精1.0%,防腐剂0.4%,水余量。
其中,抑菌粉末由质量百分比的西吡氯铵5%,硬脂酸5%,乙基纤维素70%,聚乙烯醇20%组成。
实施例2
具有抑菌作用的口腔护理组合物各组分的质量百分比为抑菌粉末2.0%,二氧化硅30.0%,山梨醇20.0%,甘油5.0%,纤维素胶0.5%,黄原胶为0.3%,十二烷基硫酸酯钠2.0%,香精1.0%,甜味剂0.2%,防腐剂0.4%,水余量。
其中,抑菌粉末由质量百分比的西吡氯铵10%,硬脂酸5%,三乙酰基-β-环糊精30%,乙基纤维素35%,聚乙烯醇20%。
实施例3
具有抑菌作用的口腔护理组合物各组分的质量百分比为抑菌粉末0.05%,碳酸钙5.0%,二氧化硅30.0%,山梨醇20.0%,丙二醇5.0%,聚乙二醇2.0%,卡拉胶0.3%,黄原胶为0.3%,烷基糖苷4.0%,椰油酰胺丙基甜菜碱4.0%,香精1%,防腐剂0.4%,水余量。
其中,抑菌粉末由质量百分比的西吡氯铵20%,硬脂酸10%,乙基纤维素60%,聚乙烯醇10%。
实施例4
具有抑菌作用的口腔护理组合物各组分的质量百分比为抑菌粉末5.0%,碳酸钙30.0%,二氧化硅5.0%,山梨醇20.0%,甘油5.0%,聚乙二醇2.0%,纤维素胶0.5%,黄原胶为0.3%,烷基糖苷8.0%,香精1.0%,防腐剂0.4%,水余量。
其中,抑菌粉末由质量百分比的西吡氯铵5%,硬脂酸5%,羟丙基-β-环糊精10%,乙基纤维素60%,聚乙烯醇20%。
对比例1
一种口腔护理组合物各组分的质量百分比为碳酸钙30.0%,二氧化硅5.0%,山梨醇20.0%,甘油5.0%,聚乙二醇2.0%,纤维素胶0.5%,黄原胶为0.3%,烷基糖苷8%,香精1%,防腐剂0.4%,水余量。
对比例2
一种口腔护理组合物各组分的质量百分比为西吡氯铵2.0%,碳酸钙30.0%,二氧化硅5.0%,山梨醇20.0%,甘油5.0%,聚乙二醇2.0%,纤维素胶0.5%,黄原胶为0.3%,烷基糖苷8%,香精1%,防腐剂0.4%,水余量。
刷牙测试
将本发明实施例1-4提供的具有抑菌作用的口腔护理组合物、对比例1-2提供的口腔护理组合物,按照牙膏的制备方法分别制得实施例1-4、对比例1-2的不同款牙膏。
随机挑选60名口腔健康的志愿者,平均分成6小组,每一小组的人员刷一款牙膏。称取约1g牙膏,按照每个人的刷牙习惯,刷牙3min,并用约300mL自来水,分5次漱口。分别对刷牙前和刷牙后2h进行唾液取样,每次吐出1g唾液进行后续的细菌培养实验。
细菌培养及计数
吸取收集的唾液样品,并进行多个梯度稀释,吸取1mL稀释液,置于平皿内,用灭菌后并凉至45℃的营养琼脂培养基15mL倾注,转动平皿,将其充分均匀混合,待琼脂凝固后翻转平皿,在生化培养箱,进行37℃培养48h后,做有氧菌活菌菌落计数。
吸取收集的唾液样品,并进行多个梯度稀释。在厌氧工作站内,吸取1mL稀释液,置于平皿内,用灭菌后并凉至45℃的营养琼脂培养基15mL倾注,转动平皿,将其充分均匀混合,待琼脂凝固后翻转平皿,进行37℃培养48h后,做无氧菌活菌菌落计数。
通过比较使用者刷牙前及刷牙后2小时的口腔内好氧菌和厌氧菌数量的减少情况来判断牙膏是否具备抑菌作用。
使用实施例1-4和对比例1-2的牙膏在刷完牙后2小时,口腔内好氧菌和厌氧菌数量减少的人数占总人数的比例如表1所示。
表1.口腔好氧菌和厌氧菌数量减少的人数占总人数的比例
实施例1 | 实施例2 | 实施例3 | 实施例4 | 对比例1 | 对比例2 | |
好氧菌 | 100% | 100% | 75% | 100% | 25% | 50% |
厌氧菌 | 75% | 75% | 75% | 100% | 25% | 50% |
从表1的结果可以看出,使用本发明实施例1~4的提供的具有抑菌作用的口腔护理组合物刷牙后,在抑菌粉末的作用下,绝大数使用者口腔内的好氧菌、厌氧菌数量具有明显的减少,刷牙2小时后仍能有效抑菌好氧菌和厌氧菌;而使用对比例1~2得到的口腔护理组合物刷牙后,只有较少部分使用者的口腔内好氧菌和厌氧菌数量有减少,抑菌效果差。
在上述实施例中,对各个实施例的描述都各有侧重,某个实施例中没有详细描述的部分,可以参见其他实施例的相关描述。
以上所述,为本发明的具体实施方式,但本发明的保护范围并不局限于此,任何熟悉本技术领域的技术人员在本发明揭露的技术范围内,可轻易想到各种等效的修改或替换,这些修改或替换都应涵盖在本发明的保护范围之内。因此,本发明的保护范围应以权利要求的保护范围为准。
Claims (10)
1.一种具有抑菌作用的口腔护理组合物,其特征在于,按质量百分比计,该口腔护理组合物包括以下组分:
0.05%~5%抑菌粉末;
10%~50%摩擦剂;
10%~60%保湿剂;
0.5%~10%发泡剂;
0.2%~2%增稠剂;
0.01%~0.5%防腐剂;
0.2%~2%香精;
余量水;
所述抑菌粉末由5%~20%抑菌剂,5%~20%控释剂,60%~90%成型剂组成。
2.如权利要求1所述的具有抑菌作用的口腔护理组合物,其特征在于,按质量百分比计,该口腔护理组合物包括以下组分:
0.05%~5%抑菌粉末;
15%~40%摩擦剂;
10%~50%保湿剂;
1%~10%发泡剂;
0.2%~2%增稠剂;
0.01%~0.5%防腐剂;
0.2%~2%香精;
余量水。
3.如权利要求1所述的具有抑菌作用的口腔护理组合物,其特征在于,按质量百分比计,该口腔护理组合物包括以下组分:
0.05%~5%抑菌粉末;
20%~40%摩擦剂;
20%~40%保湿剂;
2%~10%发泡剂;
0.2%~2%增稠剂;
0.01%~0.5%防腐剂;
0.2%~2%香精;
余量水。
4.如权利要求1-3任一项所述的具有抑菌作用的口腔护理组合物,其特征在于,所述抑菌剂选自西吡氯铵、氯己定、葡萄酸氯己定、醋酸氯己定、聚六亚甲基胍盐酸盐、二癸基二甲基氯化铵、苯扎氯铵、苯扎溴铵中的一种或多种。
5.如权利要求1-3任一项所述的具有抑菌作用的口腔护理组合物,其特征在于,所述控释剂选自硬脂酸、硬脂酸甘油酯、月桂酸、十三酸、肉豆蔻酸、十五酸、棕榈酸、十七酸、十九酸、花生酸、月桂酸月桂醇酯、棕榈酸肉豆蔻醇酯、硬脂酸月桂醇酯、软酯酸蜂花醇酯、月桂酸甘油酯、单硬酯酸甘油酯、硬脂酸乙二醇酯中的一种或多种。
6.如权利要求1-3任一项所述的具有抑菌作用的口腔护理组合物,其特征在于,所述成型剂选环糊精、纤维素衍生物、壳聚糖、聚乙烯亚胺、聚乙烯醇、羟丙基纤维素和羟乙基的一种或多种。
7.如权利要求1-3任一项所述的具有抑菌作用的口腔护理组合物,其特征在于,所述摩擦剂选自二氧化硅、碳酸钙、磷酸氢钙、微晶纤维素的一种或多种。
8.如权利要求1-3任一项所述的具有抑菌作用的口腔护理组合物,其特征在于,所述保湿剂选自山梨醇、甘油、聚乙二醇、丙二醇的一种或多种。
9.如权利要求1-3任一项所述的具有抑菌作用的口腔护理组合物,其特征在于,所述发泡剂选自十二烷基硫酸酯钠或钾盐、椰油酰胺丙基甜菜碱、月桂酰肌氨酸钠、月桂酰肌氨酸钾、烷基糖苷、月桂醇二乙醇胺中的一种或多种。
10.如权利要求1-3任一项所述的具有抑菌作用的口腔护理组合物,其特征在于,所述增稠剂选自羧甲基纤维素钠、卡拉胶、黄原胶、瓜尔胶的一种或几多种。
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