CN110353989A - A kind of artificial cerebrospinal fluid packing device - Google Patents
A kind of artificial cerebrospinal fluid packing device Download PDFInfo
- Publication number
- CN110353989A CN110353989A CN201910687225.1A CN201910687225A CN110353989A CN 110353989 A CN110353989 A CN 110353989A CN 201910687225 A CN201910687225 A CN 201910687225A CN 110353989 A CN110353989 A CN 110353989A
- Authority
- CN
- China
- Prior art keywords
- foaming
- liquid chamber
- rod
- chamber
- cerebrospinal fluid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
- A61J1/10—Bag-type containers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/1412—Containers with closing means, e.g. caps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/1462—Containers with provisions for hanging, e.g. integral adaptations of the container
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/1475—Inlet or outlet ports
Abstract
The present invention relates to a kind of artificial cerebrospinal fluid packing devices；Foaming chamber, B liquid chamber and A liquid chamber are disposed in the infusion bag from top to bottom；The B liquid chamber storage is in alkalinity and the electrolyte solution containing sodium bicarbonate, and the storage of A liquid chamber is in the acid and electrolyte solution containing glucose；Be provided between the foaming rod room and B liquid chamber, between B liquid chamber and A liquid chamber can disposable opening partition band, will foam rod room, B liquid chamber and A liquid chamber of partition band be individually insulated；The foaming rod is adhered by axis rod is fixed on infusion bag inner wall, and axis rod one end level is embedded in snorkel, and the axis rod other end is solid.The other end of snorkel is pierced by infusion bag and extends outward to form one section of open piping, and be disposed with unidirectionally only liquid valve, stopped pipe folder and pipe end nut after；Mixed gas can be passed through through snorkel；Packed exhaust outlet/dosing mouth and infusion port is arranged in the infusion bag bottom.
Description
Technical field
The invention belongs to medical solution storage and use device technical fields, and in particular to a kind of artificial cerebrospinal fluid packaging dress
It sets.
Background technique
With the development of Neuscience technology, artificial cerebrospinal fluid is in neural clinical and Neuroscience Research experiment with more
Come it is more frequent, although presently, there are various artificial cerebrospinal fluid formulas, (such as due to ingredients certain in artificial cerebrospinal fluid
Calcium, glucose, sodium bicarbonate etc.) be easy to happen precipitating and hydrolysis each other, can not long-term preservation, and make in artificial cerebrospinal fluid
Very high with the requirement in the process to pH, electrolyte concentration, vim and vigour state and aseptic condition, these factors all limit mechanical brains
Spinal fluid uses in clinical and scientific research.
Currently, Neuscience tests the artificial cerebrospinal fluid majority used Extemporaneous on the day of using, operating process is complicated,
Aseptic is difficult to ensure, is in this way the scientific research time and efforts of serious waste preciousness, and influences the safety of artificial cerebrospinal fluid.Europe
There is the artificial cerebrospinal fluid of producing scientific research purposes in U.S. minority producer, is individually packed, is used in mixed way with A/B liquid, extremely inconvenient,
The aseptic condition during hybrid manipulation is not can guarantee.The ACF- of Tokushima Japan fire shadow Ren Zhe great Zhong pharmacy Co., Ltd., Factory production
95 artificial cerebrospinal fluids are packaged in a dual-chamber bag, wherein an interior is glucose electrolyte solution, it include sodium chloride, chlorination
Calcium and magnesium chloride for electrolyte solution include sodium bicarbonate, sodium chloride, potassium chloride and potassium dihydrogen phosphate, ACF- in another room
95 artificial cerebrospinal fluids before use, by open two Room between carried out every band be mixed to form artificial cerebrospinal fluid.Although mechanical brains
The problem of spinal fluid stabilization saves is resolved, but the vim and vigour state of mixed artificial cerebrospinal fluid may be to nerve system of human body
Serious influence will be caused, promotes CO so must sufficiently foam by gaseous mixture2Content adjusts pH, can just mixed liquor be made to exist
It keeps stablizing in a period of time.
Currently, no matter the artificial cerebrospinal fluid that clinical or scientific research uses is without unified formula, packaging and operating specification.
Summary of the invention
The purpose of the present invention is to provide a kind of artificial cerebrospinal fluid packing devices, cooperate existing A, B liquid of artificial cerebrospinal fluid
Formula can guarantee the preservation steady in a long-term of artificial cerebrospinal fluid and simplify using operation sequence, improve what artificial cerebrospinal fluid used
Aseptic and safety provide safeguard for production, storage and the use of artificial cerebrospinal fluid.
A kind of artificial cerebrospinal fluid packing device sets gradually foaming chamber, B liquid chamber and A liquid chamber from top to bottom in infusion bag；
The B liquid chamber storage is in alkalinity and the electrolyte solution containing sodium bicarbonate, and the storage of A liquid chamber is in the acid and electrolyte containing glucose
Solution；Be provided between the foaming chamber and B liquid chamber, between B liquid chamber and A liquid chamber can disposable opening partition band, partition
Foaming chamber, B liquid chamber and A liquid chamber are individually insulated by band；Setting foaming rod, a hollow axis rod run through the hair in the foaming chamber
The center of rod is steeped, is full of stomata on axis rod tube wall；Axis rod one end connects level ventilation pipe, and the other end is in solid tubes and foaming chamber
Side connection, foaming rod is adhered by axis rod is fixed on foaming chamber interior walls；Oxygenous and titanium dioxide is passed through to foaming chamber through snorkel
The mixed gas of carbon；The infusion bag bottom is arranged Packed for being vented or the entrance and infusion port of dosing.
Further, the one end for being pierced by the snorkel of foaming chamber extends outwardly, and is disposed with and unidirectionally stops liquid valve, stopped pipe
Folder；The pipe end nut of salable snorkel is equipped at the nozzle of snorkel.
Further, be connected with suspension strap at the top of the infusion bag, bottom is connected with lower suspension strap, upper suspension strap and
Hanging hole is offered on lower suspension strap.
Further, for be vented or the entrance of dosing by high density elasticity silica gel plug seal；The infusion port is by film
Property sealing-plug sealing.
Further, the partition band is plastics clip chain bone item, and clip chain bone item can be achieved disposable separation and open.
Further, the foaming rod is nanometer foaming rod, is fired by fine sand, by cleaning and disinfecting, aseptic process
After form nanoporous；The foaming rod under the action of steel cylinder gaseous mixture air pressure, make gas via after axis rod from foaming rod
Nanoporous in overflow formed realize bubble.
Further, the infusion bag is made of non-PVC composite membrane；The infusion bag inner sidewall is provided with barrier film,
It is integrally formed with infusion bag；One layer of sterile transparent packaging bag of outsourcing of infusion bag, is isolated from the outside.
Further, the mixed gas includes 5%CO2And 95%O2；The dynamic of foaming rod foaming is provided by steel cylinder mixed pressure
Power.
The invention has the following beneficial effects:
1, artificial cerebrospinal fluid packing device of the invention is respectively arranged with A liquid chamber and B liquid chamber and foaming rod room, in alkalinity and will contain
The electrolyte solution of sodium bicarbonate and in acidity and the electrolyte solution containing glucose is independently stored, can effectively keep
The physicochemical property of each solution composition is steady in a long-term.
2, the present invention is provided with nanometer foaming rod at the top of the inner wall of infusion bag and axis rod is through one section of rod center of foaming
Hollow pipeline is full of stomata on tube wall, and axis rod one end is the snorkel of horizontal insertion, and the axis rod other end is solid；Foam rod
It is adhered by the both ends of axis rod fixed on infusion bag inner wall top, snorkel can be passed through containing 5%CO2And 95%O2's
Mixed gas, under the action of steel cylinder gaseous mixture air pressure, mixed gas by axis rod and nanometer foam rod to artificial cerebrospinal fluid into
Row sufficiently foaming, so that artificial cerebrospinal fluid keeps ph stability and the high bio-imitability of vim and vigour state.
3, the present invention realizes that B liquid chamber, A liquid chamber are connected to foaming rod, so that mechanical brains by ripping plastics clip chain bone item
Mixing of the spinal fluid before use, foaming step are all concentrated in the same apparatus, maintain artificial cerebrospinal fluid in mixed foaming process
In aseptic, simplify use process, improve safety.
Detailed description of the invention
Fig. 1 is schematic structural view of the invention；
Fig. 2 is the structural schematic diagram of clip chain bone item in the present invention.
Label is expressed as in attached drawing:
1, infusion bag；11, upper suspension strap；12, lower suspension strap；13, hanging hole；2, foaming chamber；21, foam rod；22, axis rod；23,
Snorkel；231, unidirectionally stop liquid valve；232, stopped pipe presss from both sides；233, pipe end nut；3, B liquid chamber；4, A liquid chamber；5, separate band；51, it presss from both sides
Chain bone item；6, entrance；7, infusion port.
Specific embodiment
It is next combined with specific embodiments below that the present invention will be described in detail.
Referring to Fig. 1 to Fig. 2, a kind of artificial cerebrospinal fluid packing device, including infusion bag 1；In the infusion bag 1 from top to bottom
It is disposed with foaming chamber 2, B liquid chamber 3 and A liquid chamber 4；The storage of B liquid chamber 3 is molten in alkaline and containing sodium bicarbonate electrolyte
Liquid, the storage of A liquid chamber 4 are individually stored in acid and the electrolyte solution containing glucose, two kinds of completely different solution of property, so that
Each self-sustaining is stablized；Disposable opening formula is provided between the foaming chamber 2 and B liquid chamber 3, between B liquid chamber 3 and A liquid chamber 4
Separate band 5, foaming chamber 2, B liquid chamber 3 and A liquid chamber 4 are individually insulated by partition band 5；Setting foaming rod 21 in the foaming chamber 2, one
Hollow axis rod 22 is full of stomata on the center of the foaming rod 21,22 tube wall of axis rod；The connection of 22 one end of axis rod is horizontal logical
Tracheae, the other end are to connect on the inside of solid tubes and foaming chamber 2, and foaming rod 21 is adhered by axis rod 22 and is fixed on 2 inner wall of foaming chamber；
Be passed through oxygenous and carbon dioxide mixed gas to foaming chamber 2 through snorkel 23, in mixed gas containing 5% CO2With 95%
O2, the foaming power that rod 21 foams is provided by steel cylinder mixed pressure；1 bottom of the infusion bag setting is Packed for being vented
Or the entrance 6 and infusion port 7 of dosing.
Further, the one end for being pierced by the snorkel 23 of foaming chamber 2 extends outwardly, and is disposed with and unidirectionally stops liquid valve
231 and stopped pipe folder 232, liquid can not by unidirectionally stop liquid valve 231 leak outward；The nozzle of snorkel 23 is pressed from both sides by stopped pipe
232 and pipe end nut 233 seal, prevent gas leakage leakage.
Further, the top of the infusion bag 1 is connected with suspension strap 11, and bottom is connected with lower suspension strap 12, upper outstanding
Hanging hole 13 is offered on lanyard 11 and lower suspension strap 12；The upper suspension strap 11 and lower suspension strap 12 are to thicken hard material
Be made, among upper suspension strap 11 and lower suspension strap 12 there are hanging hole 13 be it is convenient foam and be infused use when in different positions
Set suspension.
Further, the top of the infusion bag 1 is connected with suspension strap 11, and bottom is connected with lower suspension strap 12, upper outstanding
Hanging hole 13 is offered on lanyard 11 and lower suspension strap 12；The upper suspension strap 11 and lower suspension strap 12 are to thicken hard material
Be made, among upper suspension strap 11 and lower suspension strap 12 there are hanging hole 13 be it is convenient foam and be infused use when in different positions
Set suspension.
Further, it is sealed with the entrance 6 of dosing by the silica gel plug of high density elasticity for being vented, allows multiple thick needle
It punctures and keeps sealing function；The infusion port 7 is sealed by the sealing-plug of film property, and precision infusion set is facilitated to puncture connection.
Further, the active force of the partition band 5 for plastics clip chain bone item 51 and only from top to bottom could be by plastics
The separation of clip chain bone item 51 is opened, plastics clip chain bone caused by capable of preventing infusion bag 1 in storage and transportational process due to extruding
Item 51 automatically turns on；The partition band 5 be it is disposable, once open once can not reset isolation, thus can use preceding energy
Enough A, B liquid of discovery in time has occurred and that mixing, avoids solution from mixing in advance and causes damages that (mixed liquor is more than 48 to nervous system
Hour generates precipitating).
Further, the foaming rod 2 is nanometer foaming rod, is fired by fine sand, by cleaning and disinfecting, aseptic process
After form nanoporous so that gas by axis rod 22 enter foaming rod 21 in, foaming 21 surface of rod generate bubble it is fine and closely woven
Such as mist, preferably enter in solution；The foaming rod 21 makes gas from foaming rod 21 under the action of steel cylinder gaseous mixture air pressure
It overflows to be formed in nanoporous and realizes bubble；Meanwhile being separated using preceding foaming rod 21 by partition band 5, not with liquid
Contact prevents foaming rod 21 from being impregnated in storage transport by electrolyte and blocking nanometer stomata.
Further, the infusion bag 1 is made of non-PVC composite membrane, and inner sidewall is provided with barrier film, with infusion bag 1
It is integrally formed, so that infusion bag 1 has seepage-proof liquid and the extremely low performance of gas permeability, it is ensured that the NaHCO contained in B solution3Stablize；
1 outer packing of infusion bag is provided with sterile transparent packaging bag as sterile isolation pocket.
Use operating method of the invention:
1, the sterile transparent packaging bag of 1 outer layer of infusion bag is torn, while firmly breaks B liquid chamber 3 and A liquid chamber 4 into two with one's hands round about
Between partition band 5, and then B solution and solution A are sufficiently mixed uniformly；
2, B solution and solution A firmly break the partition band 5 between foaming rod 2 and B liquid chamber 3 into two with one's hands round about again after mixing,
Upward by lower suspension strap 12 simultaneously, infusion bag 1 is hung on infusion support by hanging hole 13, it is stand-by that exhaust needle punctures entrance 6；
3, it mixes gas cylinder and flow divider is opened, filter filters gas by the road, realizes the sterilization processing of mixed gas；It opens
Pipe end nut 233 and 232 connection gas piping of stopped pipe folder flow through mixed gas constantly to axis rod 22, gas by snorkel 21
Via foaming again to foaming rod 21 after the stomata dispersion of axis rod 22, foamed time is 10 minutes or more；
4, first close gas source after foaming, then pull out the exhaust needle on entrance 6, allow gas continue to fill under overbottom pressure effect it is defeated
Liquid bag 1 finally closes stopped pipe folder 232 so that infusion bag 1 is in bulging state, screws end nut 233.
5, infusion bag 1 is inverted, hangs infusion bag 1 using the hanging hole 13 on upper suspension strap 11, is turned off ventilation at this time
Pipe end nut 233 and stopped pipe folder 232 on the nozzle of pipe 21, are fully sealed snorkel 21；
6, related drugs addition can be carried out by entrance 6, and extracts artificial cerebrospinal fluid chemical examination.
7, perfusion tube insertion infusion port 7 can carry out drainage artificial cerebrospinal fluid use.
The above description is only an embodiment of the present invention, is not intended to limit the scope of the invention, all to utilize this hair
Equivalent structure or equivalent flow shift made by bright description is applied directly or indirectly in other relevant technology necks
Domain is included within the scope of the present invention.
Claims (8)
1. a kind of artificial cerebrospinal fluid packing device, it is characterised in that: set gradually foaming chamber from top to bottom in infusion bag (1)
(2), B liquid chamber (3) and A liquid chamber (4)；B liquid chamber (3) storage is in alkalinity and the electrolyte solution containing sodium bicarbonate, A liquid chamber
(4) storage is in the acid and electrolyte solution containing glucose；Between the foaming chamber (2) and B liquid chamber (3), B liquid chamber (3) and A liquid
Be provided between room (4) can disposable opening partition band (5), partition band (5) is by foaming chamber (2), B liquid chamber (3) and A liquid chamber
(4) it is individually insulated；Setting foaming rod (21) in the foaming chamber (2), a hollow axis rod (22) run through the foaming rod (21)
Center, stomata is full of on axis rod (22) tube wall；Axis rod (22) one end connect level ventilation pipe (23), the other end be solid tubes with
Connection on the inside of foaming chamber (2), foaming rod (21) are adhered by axis rod (22) and are fixed on foaming chamber (2) inner wall；Through snorkel (23)
Oxygenous and carbon dioxide mixed gas is passed through to foaming chamber (2)；Infusion bag (1) the bottom setting is Packed for arranging
Gas or the entrance of dosing (6) and infusion port (7).
2. a kind of artificial cerebrospinal fluid packing device as described in claim 1, it is characterised in that: be pierced by the ventilation of foaming chamber (2)
One end of pipe (23) extends outwardly, and is disposed with and unidirectionally stops liquid valve (231), stopped pipe folder (232), the nozzle of snorkel (23)
Place is equipped with the pipe end nut (233) of salable snorkel (23).
3. a kind of artificial cerebrospinal fluid packing device as claimed in claim 2, it is characterised in that: the top of the infusion bag (1)
It is connected with suspension strap (11), bottom is connected with lower suspension strap (12), is opened up on upper suspension strap (11) and lower suspension strap (12)
There are hanging hole (13).
4. a kind of artificial cerebrospinal fluid packing device as described in claim 1, it is characterised in that: for being vented or the entrance of dosing
(6) it is sealed by the silica gel plug of high density elasticity；The infusion port (7) is sealed by the sealing-plug of film property.
5. a kind of artificial cerebrospinal fluid packing device as described in claim 1, it is characterised in that: the partition band (5) is plastics
Clip chain bone item (51), clip chain bone item (51) can be achieved disposable separation and open.
6. a kind of artificial cerebrospinal fluid packaging as described in claim 1 and use device, it is characterised in that: the foaming rod (21)
For nanometer foaming rod, is fired by fine sand, form nanoporous after cleaning and disinfecting, aseptic process；The foaming rod
(21) under the action of steel cylinder gaseous mixture air pressure, make gas via after axis rod (22) from foaming rod (21) nanoporous in overflow
It is formed out and realizes bubble.
7. a kind of artificial cerebrospinal fluid packing device as described in claim 1, it is characterised in that: the infusion bag (1) is by non-PVC
Composite membrane is made；Infusion bag (1) inner sidewall is provided with barrier film, is integrally formed with infusion bag (1), infusion bag (1) is outside
One layer of sterile transparent packaging bag is wrapped to be isolated from the outside.
8. a kind of artificial cerebrospinal fluid packing device as described in claim 1, it is characterised in that: the mixed gas includes 5%CO2
And 95%O2；The power of foaming rod (21) foaming is provided by steel cylinder mixed pressure.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910687225.1A CN110353989B (en) | 2019-07-29 | 2019-07-29 | Artificial cerebrospinal fluid packaging device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910687225.1A CN110353989B (en) | 2019-07-29 | 2019-07-29 | Artificial cerebrospinal fluid packaging device |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN110353989A true CN110353989A (en) | 2019-10-22 |
| CN110353989B CN110353989B (en) | 2022-03-04 |
Family
ID=68222336
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910687225.1A Active CN110353989B (en) | 2019-07-29 | 2019-07-29 | Artificial cerebrospinal fluid packaging device |
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| CN1630539A (en) * | 2002-03-12 | 2005-06-22 | 甘布罗伦迪亚股份公司 | Multiple compartment bag assembly for dialysis fluid |
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| Publication number | Publication date |
|---|---|
| CN110353989B (en) | 2022-03-04 |
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