CN110353753A - Heart coronaries venous perfusion system and its control method - Google Patents
Heart coronaries venous perfusion system and its control method Download PDFInfo
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- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/0205—Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition
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- A—HUMAN NECESSITIES
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- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/021—Measuring pressure in heart or blood vessels
- A61B5/0215—Measuring pressure in heart or blood vessels by means inserted into the body
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- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/021—Measuring pressure in heart or blood vessels
- A61B5/0215—Measuring pressure in heart or blood vessels by means inserted into the body
- A61B5/02152—Measuring pressure in heart or blood vessels by means inserted into the body specially adapted for venous pressure
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- A61B5/024—Detecting, measuring or recording pulse rate or heart rate
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- A61B5/14542—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring blood gases
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- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
- A61B5/316—Modalities, i.e. specific diagnostic methods
- A61B5/318—Heart-related electrical modalities, e.g. electrocardiography [ECG]
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Abstract
The present invention provides a kind of heart coronaries venous perfusion system and its control method, is related to medical instruments field field.System includes internal blood flow controlling apparatus and external control module, internal blood flow controlling apparatus includes blocking full unit, it blocks full unit to block coronary venous vessel inner blood by cardiac muscle cell's atrial reflux to the right under expanded state, restores blood backflow under contraction state；External control module includes signal receiving unit and control unit, and signal receiving unit is fed back for receiving human body monitoring signals, control unit based on human body monitoring signal, and control blocks the full of full unit and shrinks.Based on human body signal judge cardiac muscle whether ischemic, control unit control blocks the full of full unit and shrinks, block full unit under expanded state, coronary venous blood flow is blocked, blood in vein counter can moisten the vein microcirculation into cardiac muscle, the myocardial region of ischemic is adequately perfused, and is guaranteed myocardial blood supply, is avoided myocardial damage caused by fluoride-free flux.
Description
Technical field
The present invention relates to medical instruments fields, and in particular to a kind of heart coronaries venous perfusion system and its control method.
Background technique
Coronary circulation is and to transport metabolic waste to provide nutriment and oxygen required for it to heart itself.
Be blood directly by aorta base portion coronary artery flow direction cardiac muscle inside capillary network finally by vein flow back to atrium dextrum,
Right ventricle flows into left room, a kind of circulation of left room after entering back into lung's exchange.Coronary artery stenosis or obstruction in coronary circulation
It will cause myocardial ischemia, anoxic or necrosis.
Acute myocardial infarction AMI is that coronary artery is acute, myocardial necrosis caused by duration hypoxic-ischemic.It is clinically to have more
Violent and lasting retrosternal pain, rest and nitrate esters medicine are unable to complete incidence graph, increase with serum enzyme activities
And progressive ECG Change, can complicated by arrhythmia, shock or heart failure, often can threat to life.Coronary heart disease myocardial infarction
It is common heart disease, there are about the raw myocardial infarctions of 1,500,000 human hairs every year in the U.S..It is Chinese to be newly sent to few 500,000 every year, now suffer to
Few 2,000,000.
Acute myocardial infarction AMI mainly uses percutaneous coronary intervention to open occluding coronary arteries at present, however in recent years
Clinic show patient although blood flow coronarius be restored, but the cardiac muscle that is dominated of occluded blood vessel is really completely
Realize the hemoperfusion in tissue level, i.e., " No-reflow phenoment ".
Summary of the invention
(1) the technical issues of solving
In view of the deficiencies of the prior art, the present invention provides a kind of heart coronaries venous perfusion system and its control method,
Help to solve the problems, such as fluoride-free flux after the coronary blood flow of Acute myocardial stalk patient restores.
(2) technical solution
In order to achieve the above object, the present invention is achieved by the following technical programs:
On the one hand, a kind of heart coronaries venous perfusion system, the system comprises:
Internal blood flow controlling apparatus, the internal blood flow controlling apparatus include blocking full unit, and the blocking is full single
Member blocks coronary venous vessel inner blood to be flowed from cardiac muscle cell to atrium dextrum under expanded state, restores blood under contraction state
It is flowed from cardiac muscle cell to atrium dextrum；
External control module, the external control module include:
Signal receiving unit, the signal receiving unit is for receiving human body signal；
Control unit, described control unit control the full and receipts for blocking full unit based on the human body signal
Contracting.
Preferably, the human body signal includes cardiac monitoring signal, vascular pressure, arteries internal pressure in cardiac veins
Power, Svo2 or/and pulse frequency.
Preferably, when the signal receiving unit judges myocardial ischemia based on human body signal, described control unit controls institute
It is full to state the full unit of blocking.
Preferably, the full unit of the blocking includes:
The proximal end of first conduit, first conduit is connected with full mechanism；
First sacculus, first balloon interior have accommodating space, and first sacculus is remote with first conduit
End connection, and the full mechanism makes first sacculus in expanded state by first conduit.
Preferably, the system also includes:
Vacuum unit, the vacuum unit block full unit to vacuumize to described.
Preferably, the internal blood flow controlling apparatus further include:
Pipeline is perfused, the intrusion pipe road has in vitro perfusion import and internal priming outlet, and the perfusion pipeline is located at
In first conduit, the in vitro perfusion import is extended to outside the proximal port of first conduit, the internal perfusion
Outlet extends to the distal outer of first conduit.
On the other hand, the present invention also provides a kind of heart coronaries vein Micro-perfusion in Graft After control methods, which is characterized in that the control
Method processed includes:
S1, human body signal is received, and the human body signal is delivered to control unit；
S2, described control unit are based on the human body signal, block full unit in control volume in blood flow controlling apparatus
Full and contraction；
Wherein, it is described block full unit blocked under expanded state coronary venous vessel inner blood by cardiac muscle cell to the right
Atrium is flowed, and is restored blood under contraction state and is flowed from cardiac muscle cell to atrium dextrum.
Preferably, the human body signal includes cardiac monitoring signal, vascular pressure, arteries internal pressure in cardiac veins
Power, Svo2 or/and pulse frequency.
Preferably, when the signal receiving unit judges myocardial ischemia based on human body signal, described control unit controls institute
It is full to state the full unit of blocking.
(3) beneficial effect
The present invention provides a kind of heart coronaries venous perfusion system and its control methods.Compared with prior art, have
Below the utility model has the advantages that
Heart coronaries venous perfusion system provided in an embodiment of the present invention is controlled by control unit based on human body signal and is hindered
Disconnected full unit full and shrink, block full unit blocked under expanded state coronary venous vessel inner blood from cardiac muscle to
Atrium dextrum is flowed, and is restored blood under contraction state and is flowed from cardiac muscle to atrium dextrum；Block full unit under expanded state, it is coronal
Venous blood flow is blocked, and since normal myocardial cells blood flows out, therefore is blocked area blood pressure rise, under pressure
Blood in the vein counter can moisten the vein microcirculation into cardiac muscle, and the myocardial region of ischemic is adequately perfused, and guarantee cardiac muscle
Blood supply avoids No-reflow phenoment.
Detailed description of the invention
In order to more clearly explain the embodiment of the invention or the technical proposal in the existing technology, to embodiment or will show below
There is attached drawing needed in technical description to be briefly described, it should be apparent that, the accompanying drawings in the following description is only this
Some embodiments of invention for those of ordinary skill in the art without creative efforts, can be with
It obtains other drawings based on these drawings.
Fig. 1 is the heart coronaries venous perfusion system schematic of the embodiment of the present invention；
Fig. 2 is the internal blood flow controlling apparatus structural schematic diagram of the embodiment of the present invention；
Fig. 3 is the internal blood flow controlling apparatus first state schematic diagram of the embodiment of the present invention；
Fig. 4 is the second status diagram of internal blood flow controlling apparatus of the embodiment of the present invention.
Specific embodiment
In order to make the object, technical scheme and advantages of the embodiment of the invention clearer, to the technology in the embodiment of the present invention
Scheme is clearly and completely described, it is clear that and described embodiments are some of the embodiments of the present invention, rather than whole
Embodiment.Based on the embodiments of the present invention, those of ordinary skill in the art are obtained without creative efforts
The every other embodiment obtained, shall fall within the protection scope of the present invention.
The embodiment of the present application solves existing by providing a kind of heart coronaries venous perfusion system and its control method
After the blood flow of the external membrane of heart occluded blood vessel of Acute myocardial stalk patient is restored, the technical issues of No-reflow phenoment.Realization will be quiet
Blood in arteries and veins is counter to moisten the vein microcirculation into cardiac muscle, so that the myocardial region of ischemic is obtained the abundant perfusion of vein, guarantees cardiac muscle
Blood supply avoids No-reflow phenoment.
Technical solution in the embodiment of the present application is in order to solve the above technical problems, general thought is as follows:
Based on by real time monitoring human body signal, automatically controls the full of the full unit of blocking and shrink.It blocks full single
Under expanded state, coronary venous blood flow is blocked member, and the blood in the vein counter can moisten into the quiet of cardiac muscle under pressure
Weak pulse circulation, the myocardial region of ischemic are adequately perfused, and are guaranteed myocardial blood supply, are avoided No-reflow phenoment.
In order to better understand the above technical scheme, in conjunction with appended figures and specific embodiments to upper
Technical solution is stated to be described in detail.
On the one hand, as shown in Figure 1, the embodiment of the present invention provides a kind of heart coronaries venous perfusion system, the system packet
Internal blood flow controlling apparatus and external control module are included, the internal blood flow controlling apparatus includes blocking full unit, the resistance
Disconnected full unit blocks coronary venous vessel inner blood to be flowed from cardiac muscle cell to atrium dextrum under expanded state, under contraction state
Restore blood flow；The external control module includes signal receiving unit and control unit, and the signal receiving unit is used for
Human body signal is received, described control unit controls the full and contraction for blocking full unit based on the human body signal.
Above-described embodiment is based on human body signal in the specific implementation process, by the feedback of human body signal, automatically controls
It blocks the full of full unit and shrinks.Block full unit under expanded state, coronary venous blood flow is blocked, due to normal
The outflow of cardiac muscle cell's blood, therefore is blocked area blood pressure rise, under pressure the blood in the vein counter can moisten into
The vein microcirculation of cardiac muscle, the myocardial region of ischemic are adequately perfused, and are guaranteed myocardial blood supply, are avoided No-reflow phenoment.This
Outside, the present embodiment gives ischemic myocardium blood supply by vein, is not limited by the obstruction of artery, caused by can reducing because of myocardial ischemia
Heart failure disease incidence.
In one embodiment, the human body signal includes cardiac monitoring signal, vascular pressure in cardiac veins, in arteries
Pressure, Svo2 or/and pulse frequency.By monitoring human body signal in real time, automatically controls and block the full of full unit
And contraction, cardiac muscle cell's blood supply is given by the reversed coronary venous blood of high frequency, can repeatedly be filled in a cardiac cycle, every time
Pulsed counterpulsation guarantees myocardial blood supply.
In one embodiment, when the cardiac monitoring signal feeds back myocardial ischemia, the described control unit control blocking is filled
The unit that is full of is full.The present embodiment provides the judgement embodiments of a human body signal, and the heart of human body is monitored by electrocardiogram monitor system
Electric monitored signal, electrocardiogram monitor system detection cardiac monitoring signal can feed back myocardial ischemia whether ischemic；When feedback cardiac muscle
When ischemic, signal element receives signal, and control unit control blocks full unit full, blocks full unit in expanded state
Under, coronary venous blood flow is blocked, and the blood in the vein counter can moisten the vein microcirculation into cardiac muscle, ischemic under pressure
Myocardial region be adequately perfused, guarantee myocardial blood supply, avoid No-reflow phenoment.It should be noted that can also use
Other human body signals judge and control, vascular pressure, arterial blood overpressure, venous blood in such as above-mentioned cardiac veins
Oxygen saturation or pulse frequency, naturally it is also possible to using the collaboration judgement of multiple human body signals.
It is described that full unit is blocked to include the first conduit 2 and the first sacculus 1 as shown in 2~4 in one embodiment, wherein should
The proximal end interconnecting piece of first conduit 2 has full mechanism 4, inside first sacculus 1 have accommodating space, first sacculus 1 with should
The distal end of first conduit 2 is connected to, and the full mechanism 4 makes first sacculus 1 in expanded state by first conduit 2.
Above-described embodiment is in the specific implementation process, wherein Fig. 3 is 1 contraction state of the first sacculus, and Fig. 4 is the first sacculus 1
Expanded state.When ischemic state is presented in cardiac muscle, the first sacculus 1 is placed in heart coronaries vein by performing the operation, fills mechanism 4
First sacculus 1 is filled by the first conduit 2, the accommodating space inside the first sacculus 1 is filled, so that the first sacculus 1
In expanded state, the first sacculus 1 under expanded state, which forms vein, to be blocked, to realize to blocking coronary venous close to the right heart
The one end in room, prevent the blood flow of vein, from being back to atrium dextrum, the blood in the vein counter can moisten into the heart under pressure
The vein microcirculation of flesh, the myocardial region of ischemic are adequately perfused, and are guaranteed myocardial blood supply, are avoided the occurrence of No-reflow phenoment and lead
The myocardial necrosis of cause.
In one embodiment, as shown in figs. 34, the system also includes vacuum device 5,5 pairs of institutes of the vacuum device
Occluding device is stated to be vacuumized.Specific embodiment needs to vacuumize it before system work.
In one embodiment, as shown in Fig. 2, the full unit of the blocking further includes perfusion pipeline 3, the perfusion pipeline 3 has
There are in vitro perfusion entrance and internal priming outlet, the drug release pipeline 3 is located in first conduit 2, the medicine outlet
It extends to outside first conduit 2, the feeding opening extends to the outside of first sacculus 1, passes through drug release pipeline 3
It is administered, to carry out drug adjuvant treatment.It can be precisely administered to ischemic myocardium by the way that pipeline 3 is perfused, activate damaged myocardium, filled
Oxygen part content in venous blood also can be improved in note pipeline 3.
As shown in figs. 2 to 4, which includes having accommodating empty inside cavity 401 and piston 402 cavity 401
Between, piston 402 is located in the accommodating space of the cavity 401, and slides along the length direction of the accommodating space of cavity 401.
Specifically, gas or liquid in cavity 401 are pushed to the by piston 402 when piston 402 generates reciprocating motion in cavity 401
One conduit 2 is so that the first sacculus 1 is full.It should be noted that the sealing in order to promote piston 402, in the side of piston 402
Sealing ring 4021 is set, and sealing ring 4021 is slided along 401 inner wall of cavity.
In the specific implementation process, it is also provided with motor 403, through the driving plug 402 of motor 403 in cavity 401
Reciprocating motion is generated, the first sacculus 1 is filled and shunk.
In addition, a triple valve is arranged in the proximal end of the first conduit 2 the embodiment of the invention also provides a kind of connection structure
201, vacuum device 5 and full mechanism 4 are separately connected by triple valve 201.It should be noted that may be used also in specific implementation
To select other connection types as needed.
In the specific implementation process, pressure monitoring unit 601 can also be included, the pressure monitoring unit 601 is for monitoring the heart
The blood pressure of dirty vein, the pressure that the pressure monitoring unit 601 monitors reach human body by pressure monitoring unit pipe 6
Outside, which can be set in the first conduit 2, monitor the pressure of venous blood in real time, prevent from blocking
In the process, injury of myocardium excessive with artery pressure difference in the vein blood vessel being blocked.
Still further aspect, the embodiment of the present invention also provide a kind of heart coronaries vein Micro-perfusion in Graft After control method, the control
Method includes:
S1, human body signal is received, and the human body signal is delivered to control unit；
S2, described control unit are based on the human body signal, block full unit in control volume in blood flow controlling apparatus
Full and contraction；
Wherein, it is described block full unit blocked under expanded state coronary venous vessel inner blood by cardiac muscle cell to the right
Atrial reflux restores blood backflow under contraction state.
In one embodiment, the human body signal includes cardiac monitoring signal, vascular pressure in cardiac veins, in arteries
Pressure, Svo2 or/and pulse frequency guarantee the accuracy of vein blood supply by human body signal monitoring signals.
In one embodiment, when the cardiac monitoring signal feeds back myocardial ischemia, described control unit controls the blocking
Full unit is full.
Above-described embodiment specifically, as shown in Figure 1, by electrocardiogram monitor system monitor human body cardiac monitoring signal, and
Feedback signal reception unit, when the signal of feedback is myocardial ischemia, the signal of myocardial ischemia is transferred to control by signal receiving unit
Unit processed, control unit output signal vacuumize the full unit of blocking, and then start full mechanism, fill so that blocking
The unit that is full of is in expanded state, and the blocking under expanded state fills unit and forms blocking to vein, to realize coronal quiet to blocking
Arteries and veins is close to one end of atrium dextrum, prevent the blood flow of vein is from being back to atrium dextrum, the blood in the vein under pressure
It counter can moisten the vein microcirculation into cardiac muscle, the myocardial region of ischemic is adequately perfused, and is guaranteed myocardial blood supply, is avoided the occurrence of nothing
Myocardial necrosis caused by reflow Phenomenon.
Above-mentioned pressure monitoring unit 601 is used for the blood pressure of monitoring of cardiac vein in implementation process, and the pressure is supervised
It surveys the pressure that unit 601 monitors to reach outside human body by pressure monitoring unit pipe 6, which can set
Set in the first conduit 2, monitor the pressure of venous blood in real time, prevent in vein blood vessel during blocking, being blocked with
Artery pressure difference is excessive, injury of myocardium.
Meanwhile it can be by being administered by drug release pipeline 3, to carry out drug adjuvant treatment.
It should be noted that the present embodiment provides the judgement embodiment on the basis of a kind of signal by cardiac monitoring, it is specific real
It can also be judged and control using other human body signals when applying, vascular pressure, arterial blood in such as above-mentioned cardiac veins
Overpressure, Svo2 or pulse frequency, naturally it is also possible to using the collaboration judgement of multiple human body signals.
In conclusion compared with prior art, have it is following the utility model has the advantages that
Heart coronaries venous perfusion system provided in an embodiment of the present invention, it is full single by control blocking based on human body signal
The full and contraction of member, blocks full unit that coronary venous vessel inner blood is blocked to be returned under expanded state from cardiac muscle to atrium dextrum
It flows, restores blood backflow under contraction state；Block full unit under expanded state, coronary venous blood flow is blocked, due to just
Normal cardiac muscle cell's blood outflow, therefore it is blocked area blood pressure rise, the blood in the vein counter can moisten under pressure
Enter the vein microcirculation of cardiac muscle, the myocardial region of ischemic is adequately perfused, and is guaranteed myocardial blood supply, is avoided No-reflow phenoment.
It should be noted that, in this document, relational terms such as first and second and the like are used merely to a reality
Body or operation are distinguished with another entity or operation, are deposited without necessarily requiring or implying between these entities or operation
In any actual relationship or order or sequence.Moreover, the terms "include", "comprise" or its any other variant are intended to
Non-exclusive inclusion, so that the process, method, article or equipment including a series of elements is not only wanted including those
Element, but also including other elements that are not explicitly listed, or further include for this process, method, article or equipment
Intrinsic element.In the absence of more restrictions, the element limited by sentence "including a ...", it is not excluded that
There is also other identical elements in process, method, article or equipment including the element.
The above embodiments are merely illustrative of the technical solutions of the present invention, rather than its limitations；Although with reference to the foregoing embodiments
Invention is explained in detail, those skilled in the art should understand that: it still can be to aforementioned each implementation
Technical solution documented by example is modified or equivalent replacement of some of the technical features；And these modification or
Replacement, the spirit and scope for technical solution of various embodiments of the present invention that it does not separate the essence of the corresponding technical solution.
Claims (9)
1. a kind of heart coronaries venous perfusion system, which is characterized in that the system comprises:
Internal blood flow controlling apparatus, the internal blood flow controlling apparatus includes blocking full unit, described that full unit is blocked to exist
It blocks coronary venous vessel inner blood to be flowed from cardiac muscle cell to atrium dextrum under expanded state, restores blood under contraction state by the heart
Myocyte is flowed to atrium dextrum；
External control module, the external control module include:
Signal receiving unit, the signal receiving unit is for receiving human body signal；
Control unit, described control unit control the full and contraction for blocking full unit based on the human body signal.
2. heart coronaries venous perfusion system as described in claim 1, which is characterized in that the human body signal includes cardiac monitoring
Vascular pressure, arterial blood overpressure, Svo2 or/and pulse frequency in signal, cardiac veins.
3. heart coronaries venous perfusion system as claimed in claim 2, which is characterized in that the signal receiving unit is based on human body
When signal judges myocardial ischemia, described control unit control is described to block full unit full.
4. heart coronaries venous perfusion system as described in claim 1, which is characterized in that the blocking fills unit and includes:
The proximal end of first conduit, first conduit is connected with full mechanism；
First sacculus, first balloon interior have accommodating space, and the distal end of first sacculus and first conduit connects
It is logical, and the full mechanism makes first sacculus in expanded state by first conduit.
5. heart coronaries venous perfusion system as described in claim 1, which is characterized in that the system also includes:
Vacuum unit, the vacuum unit block full unit to vacuumize to described.
6. heart coronaries venous perfusion system as described in claim 1, which is characterized in that the internal blood flow controlling apparatus also wraps
It includes:
Pipeline is perfused, the intrusion pipe road has in vitro perfusion import and internal priming outlet, and the perfusion pipeline is located at described
In first conduit, the in vitro perfusion import is extended to outside the proximal port of first conduit, the internal priming outlet
Extend to the distal outer of first conduit.
7. a kind of heart coronaries vein Micro-perfusion in Graft After control method, which is characterized in that the control method includes:
S1, human body signal is received, and the human body signal is delivered to control unit；
S2, described control unit are based on the human body signal, block the full of full unit in control volume in blood flow controlling apparatus
And contraction；
Wherein, described that full unit is blocked to block coronary venous vessel inner blood from cardiac muscle cell to atrium dextrum under expanded state
It flows, restores blood under contraction state and flowed from cardiac muscle cell to atrium dextrum.
8. heart coronaries vein Micro-perfusion in Graft After control method as claimed in claim 7, which is characterized in that the human body signal includes the heart
Vascular pressure, arterial blood overpressure, Svo2 or/and pulse frequency in electric monitored signal, cardiac veins.
9. heart coronaries vein Micro-perfusion in Graft After control method as claimed in claim 7, which is characterized in that the signal receiving unit base
When human body signal judges myocardial ischemia, described control unit control is described to block full unit full.
Priority Applications (2)
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| CN201910579588.3A CN110353753A (en) | 2019-06-28 | 2019-06-28 | Heart coronaries venous perfusion system and its control method |
| PCT/CN2020/096474 WO2020259357A1 (en) | 2019-06-28 | 2020-06-17 | Coronary venous perfusion system and control method therefor |
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| CN201910579588.3A CN110353753A (en) | 2019-06-28 | 2019-06-28 | Heart coronaries venous perfusion system and its control method |
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Cited By (3)
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| WO2020259357A1 (en) * | 2019-06-28 | 2020-12-30 | 北京康瑞迪医疗科技有限公司 | Coronary venous perfusion system and control method therefor |
| CN115429373A (en) * | 2022-11-07 | 2022-12-06 | 中南大学 | Human self-powered intelligent regional blood flow control device |
| CN116687493A (en) * | 2023-06-21 | 2023-09-05 | 济宁医学院 | Liver gate blocking device under laparoscope |
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| WO2020259357A1 (en) | 2020-12-30 |
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