CN110353645A - Measurement is without waveform phase pressure, ratio approach, device, system and storage medium - Google Patents
Measurement is without waveform phase pressure, ratio approach, device, system and storage medium Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/02007—Evaluating blood vessel condition, e.g. elasticity, compliance
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/021—Measuring pressure in heart or blood vessels
- A61B5/02108—Measuring pressure in heart or blood vessels from analysis of pulse wave characteristics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/021—Measuring pressure in heart or blood vessels
- A61B5/0215—Measuring pressure in heart or blood vessels by means inserted into the body
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Abstract
This application provides a kind of measurements without waveform phase pressure, ratio approach, device, system and storage medium, and the method for measuring the instantaneous coronary artery mean pressure without the waveform phase includes: the real-time pressure value for acquiring patient；Determine patient's no waveform phase coronarius；According to the determining patient no waveform phase coronarius, the pressure value of the no waveform phase is extracted, according to the pressure value, calculates the instantaneous coronary artery mean pressure for being in synchronization with the pressure value.The application is not necessarily to only can determine no waveform phase, and real-time pressure value of the patient without the waveform phase collected from clinical or other approach by invasive pressure waveform according to electrocardiogram；The instantaneous coronary artery mean pressure without the waveform phase that synchronization is in the pressure value can be obtained, electrocardiogram must be relied on just in the prior art by, which solving the problems, such as, can measure the instantaneous coronary artery mean pressure of no waveform phase, measure easier, accuracy height.
Description
Technical field
The present invention relates to coronary artery medicine technology fields, more particularly to a kind of measurement without waveform phase pressure, instantaneous nothing
Method, apparatus, coronary analysis system and the computer storage medium of waveform ratio.
Background technique
In recent years, it due to introducing a kind of new index iFR for detecting degree of stenosis based on pressure, pushes
The development in coronary artery physiology field；Pass through the remote pressure value obtained without the waveform phase in diastole, iFR measurement
Physiological effect of the coronary artery stenosis to distal end coronary artery.
Real-time iFR pressure measurement Combined with Percutaneous Percutantnoeus coronary intervention (PCI) or coronary analysis systematic treating, imply
The new example of functional lesion assessment, proves using physiology and instructs best percutaneous coronary intervention.
ADVISE is the study found that when certain time of diastole is (referred to as without waveform phase wave-free
Period), cardiac muscle disappears to vascular compression effect in maximum diastole state, and it is most stable that capilary resistance is opposite in coronary artery
And be that the mean resistance that reaches during the minimum coronary artery that is made into blood vessel dilatations drugs such as adenosines is congested is similar, reach
Maximum blood volume perfusion.
The prior art needs to be used according to electrocardiographic wave and the collocation of pressure waveform curve, and positioning obtains no waveform phase.By
This is it is found that electrocardiogram is necessary condition of the prior art positioning without the waveform phase；But when carrying out the measurement of coronary artery function assessment,
Probably due to the reasons such as model of equipment can not match electrocardiogram with pressure waveform, cause the two that can not be used in conjunction with,
It causes that no waveform phase can not be accurately positioned, leads to not the instantaneous mean pressure for calculating no waveform phase.
Summary of the invention
The present invention provides a kind of instantaneous coronary artery mean pressure of the measurement without the waveform phase, the method instantaneously without waveform ratio, dresses
It sets, coronary analysis system and computer storage medium, can not be accurately positioned when solving and lacking electrocardiogram in the prior art
Without the waveform phase, the problem of instantaneous mean pressure of no waveform phase can not be calculated.
To achieve the above object, in a first aspect, this application provides a kind of instantaneous coronary artery mean pressure of the measurement without the waveform phase
Method, comprising:
Acquire the real-time pressure value of patient；
Determine patient's no waveform phase coronarius；
According to determining patient's no waveform phase coronarius, the pressure value of the no waveform phase is extracted, according to the blood
Pressure value calculates the instantaneous coronary artery mean pressure that synchronization is in the pressure value.
Optionally, the method for instantaneous coronary artery mean pressure of the above-mentioned measurement without the waveform phase, determining patient's coronary artery
The method without the waveform phase include: the invasive pressure waveform within a cardiac cycle, be located at diastole again win incisura after extremely
Invasive pressure waveform before systole phase is patient's no waveform phase coronarius.
Optionally, the method for instantaneous coronary artery mean pressure of the above-mentioned measurement without the waveform phase, the reality of the acquisition patient
When pressure value include: acquire patient real-time diastolic pressure.
Optionally, the method for instantaneous coronary artery mean pressure of the above-mentioned measurement without the waveform phase, according to the pressure value, calculate with
The pressure value is in the formula of the instantaneous coronary artery mean pressure of synchronization are as follows:
Pw=Pd+K；
Wherein, PwIndicate the instantaneous coronary artery mean pressure of no waveform phase, PdIndicating the real-time diastolic pressure of no waveform phase, K is 5~
20 constant.
Optionally, the method for instantaneous coronary artery mean pressure of the above-mentioned measurement without the waveform phase, the constant that the K is 10~12.
Optionally, the method for instantaneous coronary artery mean pressure of the above-mentioned measurement without the waveform phase, the reality of the acquisition patient
When pressure value include: acquire patient real-time diastolic pressure and real-time systolic pressure.
Optionally, the method for instantaneous coronary artery mean pressure of the above-mentioned measurement without the waveform phase, according to the pressure value, calculate with
Pressure value is in the formula of the instantaneous coronary artery mean pressure of synchronization are as follows:
Pw=Pd+(Ps-Pd)/n；
Wherein, PwIndicate the instantaneous coronary artery mean pressure of no waveform phase, PdIndicate the real-time diastolic pressure of no waveform phase, PsIt indicates
Real-time systolic pressure of the patient without the waveform phase, the constant that n is 3~10.
Optionally, the method for instantaneous coronary artery mean pressure of the above-mentioned measurement without the waveform phase, the constant that the n is 6~8.
Optionally, the method for instantaneous coronary artery mean pressure of the above-mentioned measurement without the waveform phase, according to the pressure value, calculate with
Pressure value is in the formula of the instantaneous coronary artery mean pressure of synchronization are as follows:
Pm=(2 × Pd+Ps)/3；
Pw=a × Pm；
Wherein, PwIndicate the instantaneous coronary artery mean pressure of no waveform phase, PmIndicate the real-time mean arterial pressure of no waveform phase, Pd
Indicate the real-time diastolic pressure of no waveform phase, PsIndicate the real-time systolic pressure of no waveform phase, the constant that a is 0.5~1.5.
Optionally, the method for instantaneous coronary artery mean pressure of the above-mentioned measurement without the waveform phase, a be 0.8~0.9 it is normal
Number.
Second aspect, a kind of method this application provides measurement instantaneously without waveform ratio, comprising:
The method of instantaneous coronary artery mean pressure of the above-mentioned measurement without the waveform phase；
According to the method for the instantaneous coronary artery mean pressure of the measurement without the waveform phase, the stenotic lesion distal end without the waveform phase is calculated
Instantaneous coronary artery mean pressure PdwWith the instantaneous AoMP Pa of no waveform phasew；
According to the instantaneous coronary artery mean pressure PdwWith the instantaneous AoMP Paw, calculate instantaneously without waveform ratio
iFR。
Optionally, method of the above-mentioned measurement instantaneously without waveform ratio, if the no waveform phase calculate separately to obtain it is N number of
PdwAnd Paw, then N number of instantaneous coronary artery mean pressure Pd is calculatedwAverage valueWith N number of instantaneous AoMP PawBe averaged
Value
According to average valueWithIt calculates instantaneously without waveform ratio iFR, specific formula are as follows:
The third aspect, this application provides a kind of dresses of instantaneous coronary artery mean pressure for above-mentioned measurement without the waveform phase
It sets, comprising: no waveform identification unit, blood pressure acquisition unit and instantaneous coronary artery mean pressure measuring unit, the no waveform identification are single
First, the described blood pressure acquisition unit is connect with the instantaneous coronary artery mean pressure measuring unit；
The no waveform identification unit is for determining patient's no waveform phase coronarius；
The blood pressure acquisition unit is used to acquire the pressure value of patient；
The instantaneous coronary artery mean pressure measuring unit is used to extract institute according to determining patient's no waveform phase coronarius
The pressure value of the no waveform phase in blood pressure acquisition unit is stated, the instantaneous coronary artery for being in synchronization with the pressure value is calculated
Mean pressure.
Optionally, the device of instantaneous coronary artery mean pressure of the above-mentioned measurement without the waveform phase, the blood pressure acquisition unit is easypro
Open pressure acquisition module；The diastolic pressure acquisition module is used to acquire the real-time diastolic pressure of patient, and the instantaneous coronary artery mean pressure is surveyed
Unit is measured according to formula Pw=Pd+ K is calculated, and obtains instantaneous coronary artery mean pressure Pw, wherein PdIndicate the real-time diastole of no waveform phase
Pressure, the constant that K is 5~20；Or
The blood pressure acquisition unit includes diastolic pressure acquisition module and systolic pressure acquisition module, the diastolic pressure acquisition module
It is connect with the instantaneous coronary artery mean pressure measuring unit with the systolic pressure acquisition module；The diastolic pressure acquisition module is used for
The real-time diastolic pressure of patient is acquired, the systolic pressure acquisition module is used to acquire the real-time systolic pressure of patient；The instantaneous coronary artery
Mean pressure measuring unit calculates instantaneous coronary artery mean pressure P according to the following two kinds formulaw:
①Pw=Pd+(Ps-Pd)/n；
Wherein, PdIndicate the real-time diastolic pressure of no waveform phase, PsIndicate real-time systolic pressure of the patient without the waveform phase, n be 3~
10 constant；
②Pm=(2 × Pd+Ps)/3；
Pw=a × Pm；
Wherein, PdIndicate the real-time diastolic pressure of no waveform phase, PsIndicate real-time systolic pressure of the patient without the waveform phase, PmIt indicates
Real-time mean arterial pressure without the waveform phase, the constant that a is 0.5~1.5.
Fourth aspect, this application provides a kind of coronary analysis systems, comprising: above-mentioned measurement is instantaneous without the waveform phase
The device of coronary artery mean pressure.
5th aspect, this application provides a kind of computer storage medium, realization when computer program is executed by processor
The method of instantaneous coronary artery mean pressure of the above-mentioned measurement without the waveform phase.
Scheme bring beneficial effect provided by the embodiments of the present application includes at least:
This application provides method of the measurement without the coronary artery mean pressure of waveform phase, without only passing through invasive pressure according to electrocardiogram
Reeb shape can determine no waveform phase, and real-time blood pressure of the patient without the waveform phase collected from clinical or other approach
Value；According to determining patient's no waveform phase coronarius, the pressure value of the no waveform phase is extracted, according to the pressure value,
It calculates and is in the instantaneous coronary artery mean pressure without the waveform phase of synchronization with the pressure value, solving in the prior art must be according to
Bad electrocardiogram can just measure the problem of instantaneous coronary artery mean pressure of no waveform phase, measure easier, accuracy height.
Detailed description of the invention
The drawings described herein are used to provide a further understanding of the present invention, constitutes a part of the invention, this hair
Bright illustrative embodiments and their description are used to explain the present invention, and are not constituted improper limitations of the present invention.In the accompanying drawings:
Fig. 1 is the measurement of the application without the flow chart of the method for the instantaneous coronary artery mean pressure of waveform phase；
Fig. 2 is the flow chart of method of the measurement of the application instantaneously without waveform ratio；
Fig. 3 is the structural frames of the one embodiment for the device that the application is used to measure the instantaneous coronary artery mean pressure without the waveform phase
Figure；
Fig. 4 is the structural frames of another embodiment for the device that the application is used to measure the instantaneous coronary artery mean pressure without the waveform phase
Figure；
Fig. 5 is invasive pressure waveform figure；
Appended drawing reference is illustrated below:
No waveform identifies unit 100, blood pressure acquisition unit 200, diastolic pressure acquisition module 210, systolic pressure acquisition module
220, instantaneous coronary artery mean pressure measuring unit 300.
Specific embodiment
To make the object, technical solutions and advantages of the present invention clearer, below in conjunction with the specific embodiment of the invention and
Technical solution of the present invention is clearly and completely described in corresponding attached drawing.Obviously, described embodiment is only the present invention one
Section Example, instead of all the embodiments.Based on the embodiments of the present invention, those of ordinary skill in the art are not doing
Every other embodiment obtained under the premise of creative work out, shall fall within the protection scope of the present invention.
Multiple embodiments of the invention will be disclosed with schema below, as clearly stated, the details in many practices
It will be explained in the following description.It should be appreciated, however, that the details in these practices is not applied to limit the present invention.Also
It is to say, in some embodiments of the invention, the details in these practices is non-essential.In addition, for the sake of simplifying schema,
Some known usual structures and component will be painted it in the drawings in simply illustrative mode.
As shown in Figure 1, this application provides a kind of methods for measuring the instantaneous coronary artery mean pressure without the waveform phase, comprising:
S01 acquires the real-time pressure value of patient；
S02 determines patient's no waveform phase coronarius；
S03 extracts the pressure value without the waveform phase according to determining patient's no waveform phase coronarius, according to pressure value,
Calculate the instantaneous coronary artery mean pressure that synchronization is in pressure value.
This application provides method of the measurement without the coronary artery mean pressure of waveform phase, without only passing through invasive pressure according to electrocardiogram
Reeb shape can determine no waveform phase, and real-time blood pressure of the patient without the waveform phase collected from clinical or other approach
Value；According to determining patient's no waveform phase coronarius, the pressure value of the no waveform phase is extracted, according to the pressure value,
It calculates and is in the instantaneous coronary artery mean pressure without the waveform phase of synchronization with the pressure value, solving in the prior art must be according to
Bad electrocardiogram can just measure the problem of instantaneous coronary artery mean pressure of no waveform phase, measure easier, accuracy height.
Embodiment 1:
Step S01 includes: the real-time diastolic pressure for acquiring patient；
Step S02 includes: the invasive pressure waveform within a cardiac cycle, is located at extremely contraction after diastole fluctuation
Invasive pressure waveform before phase fluctuation is patient's no waveform phase coronarius；
Step S03 includes: the patient's no waveform phase coronarius determined according to S01, extracts the reality without the waveform phase in S02
When diastolic pressure the instantaneous coronary artery mean pressure without the waveform phase that synchronization is in diastolic pressure calculated according to real-time diastolic pressure
Formula are as follows:
Pw=Pd+K；
Wherein, PwIndicate the instantaneous coronary artery mean pressure of no waveform phase, PdIndicating the real-time diastolic pressure of no waveform phase, K is 5~
20 constant；Preferably, the constant that K is 10~12.
Embodiment 2:
Step S01 includes: the real-time diastolic pressure for acquiring patient and real-time systolic pressure；
Step S02 includes: the invasive pressure waveform within a cardiac cycle, to receipts after diastole again rich incisura
Invasive pressure waveform before the contracting phase is patient's no waveform phase coronarius；
Step S03 includes: that it is flat to calculate the instantaneous coronary artery without the waveform phase for being in synchronization with pressure value according to pressure value
The formula pressed are as follows:
Pw=Pd+(Ps-Pd)/n；
Wherein, PwIndicate the instantaneous coronary artery mean pressure of no waveform phase, PdIndicate the real-time diastolic pressure of no waveform phase, PsIt indicates
Real-time systolic pressure of the patient without the waveform phase, the constant that n is 3~10；Preferably, the constant that n is 6~8.
Embodiment 3:
Step S01 includes: to acquire the real-time pressure value of patient to include: the real-time diastolic pressure of acquisition patient and shrink in real time
Pressure；
Step S02 includes: the invasive pressure waveform within a cardiac cycle, wins incisura such as Fig. 5 again positioned at diastole
Shown in fluctuate D point to the systole phase after C point before invasive pressure waveform be patient's no waveform phase coronarius；
Step S03 includes: that it is flat to calculate the instantaneous coronary artery without the waveform phase for being in synchronization with pressure value according to pressure value
The formula pressed are as follows:
Pm=(2 × Pd+Ps)/3；
Pw=a × Pm；
Wherein, PwIndicate the instantaneous coronary artery mean pressure of no waveform phase, PmIndicate the real-time mean arterial pressure of no waveform phase, Pd
Indicate the real-time diastolic pressure of no waveform phase, PsIndicate the real-time systolic pressure of no waveform phase, the constant that a is 0.5~1.5.Preferably,
The constant that a is 0.8~0.9.
The application is specifically described below with reference to specific implementation data:
The diastolic pressure P without the waveform phase that the application is extracted from clinicd, systolic pressure PsThe P measured with seal wirewNumerical value, and
Mean arterial pressure P obtained by calculationm, and the P being calculated by embodiment 1, embodiment 2 and embodiment 3wSuch as table one,
Wherein, the K value in embodiment 1 is 10, and the n value in embodiment 2 is 6, and a value in embodiment 3 is 0.9:
Table one
As can be seen from the table above, the instantaneous coronary artery mean pressure without the waveform phase that embodiment 1, embodiment 2 and embodiment 3 are calculated
PwThe P measured with seal wirewIt is essentially identical.
(1) P for measuring embodiment 1 and seal wirewIt is compared, according to numeric order from small to large, difference is respectively
1.4,0.6,0.2,2.7,0.1,4.1,1.2,0.3, from difference comparsion it is found that only two values are more than 2, remove maximum value
4.1 and minimum value 0.1 mean value calculation is carried out to difference, show that difference average value is 1.06, therefore the P that embodiment 1 measureswWith
The practical P that seal wire measureswIt is extremely close, and from showing that the difference for having half in total data only has 0.5 or so in difference comparsion, it is quasi-
Exactness is very high, and stability is very high.
(2) P for measuring embodiment 2 and seal wirewIt is compared, according to numeric order from small to large, difference is respectively
1.2,0.4,1.0,0.5,2.7,2.4,3.1,1.4, from difference comparsion it is found that only two values are more than 2, remove maximum value
3.1 and minimum value 0.4 mean value calculation is carried out to difference, show that difference average value is 1.53, therefore the P that embodiment 2 measureswWith
The practical P that seal wire measureswIt is extremely close, and the difference comparsion being calculated is concentrated, stability is high, and accuracy is very high, but real
The accuracy and stability for applying example 2 are all slightly below embodiment 1.
(3) P for measuring embodiment 3 and seal wirewIt is compared, according to numeric order from small to large, difference is respectively
6.6,3.1,0.1,1.6,6.1,1.7,6.1,2.8, from difference comparsion it is found that removing maximum value 6.6 and minimum value 0.1 to difference
Mean value calculation is carried out, show that difference average value is 3.56, therefore the P that embodiment 3 measureswThe practical P measured with seal wirewIt is close,
But the result being calculated does not have embodiment 1 and embodiment 2 to stablize, accuracy is high, but the accuracy of embodiment 3 is lower than real
Apply example 2.
To sum up, the P that embodiment 1, embodiment 2 and embodiment 3 measurewThe true P measured with seal wirewCompare, as a result unusual phase
Both closely, accuracy is high, stability is high, and solving in the prior art can not match electrocardiogram with pressure waveform, cause
When can not be used in conjunction with, caused by can not be accurately positioned no waveform phase, lead to not the instantaneous mean pressure for calculating no waveform phase
Problem；And accuracy is sorted are as follows: 1 > embodiment of embodiment, 2 > embodiment 3；Stability sequence are as follows: 1 > embodiment of embodiment, 2 >
Embodiment 3.
As shown in Fig. 2, a kind of method this application provides measurement instantaneously without waveform ratio, comprising:
S11, the method for instantaneous coronary artery mean pressure of the above-mentioned measurement without the waveform phase；
S12 calculates the stenotic lesion distal end without the waveform phase according to the method for instantaneous coronary artery mean pressure of the measurement without the waveform phase
Instantaneous coronary artery mean pressure PdwWith the instantaneous AoMP Pa of no waveform phasew；
S13, according to instantaneous coronary artery mean pressure PdwWith instantaneous AoMP Paw, calculate instantaneously without waveform ratio iFR.
In one embodiment of the application, in S13 further include: if calculating separately to obtain N number of Pd without the waveform phasewAnd Paw,
Then calculate N number of instantaneous coronary artery mean pressure PdwAverage valueWith N number of instantaneous AoMP PawAverage value
According to average valueWithIt calculates instantaneously without waveform ratio iFR, specific formula are as follows:
Data are calculated to iFR below with reference to specific implementation data to be specifically described:
As shown in figure 5, invasive pressure waveform A indicates AoMP PawReal-time change curve, invasive pressure waveform
B indicates coronary artery mean pressure PdwReal-time change curve, straight line M is flat for N number of instantaneous coronary artery of the stenotic lesion distal end of no waveform phase
Press PdwAverage valueThe ordinate vertical line of point；Therefore the crosspoint a of straight line M and invasive pressure waveform A is nothing
The average value of the pressure of the stenotic lesion distal end of waveform phaseThe crosspoint b of straight line M and invasive pressure waveform B is no waveform
The average value of the AoMP of phase, that is, stenotic lesion proximal end pressureCrosspoint a'sIt hands over
Crunode b'sIFR=82.5/89.7=0.92.
In conclusion the application is not necessarily to electrocardiogram, no waveform phase can determine by invasive pressure waveform, then by relaxing
IFR value can be obtained in the measurement for opening pressure and systolic pressure, and measurement is simpler, and the measurement of the instantaneous mean pressure due to no waveform phase
Accuracy is high, therefore the measuring accuracy of iFR is high.
As shown in figure 3, this application provides a kind of dresses of instantaneous coronary artery mean pressure for above-mentioned measurement without the waveform phase
It sets, comprising: no waveform identification unit 100, blood pressure acquisition unit 200 and instantaneous coronary artery mean pressure measuring unit 300, no waveform mirror
Order member 100, blood pressure acquisition unit 200 are connect with instantaneous coronary artery mean pressure measuring unit 300；No waveform identifies unit 100
For determining patient's no waveform phase coronarius；Blood pressure acquisition unit 200 is used to acquire the pressure value of patient；Instantaneous coronary artery is flat
Pressure measuring unit 300 is used to extract the nothing in blood pressure acquisition unit 200 according to determining patient's no waveform phase coronarius
The pressure value of waveform phase calculates the instantaneous coronary artery mean pressure without the waveform phase that synchronization is in pressure value.
In one embodiment of the application, blood pressure acquisition unit 200 is diastolic pressure acquisition module 210 as shown in Figure 4；It relaxes
Pressure acquisition module 210 is used to acquire the real-time diastolic pressure of patient, and instantaneous coronary artery mean pressure measuring unit 300 is according to formula Pw=
Pd+ K is calculated, and obtains instantaneous coronary artery mean pressure Pw, wherein PdIndicate the real-time diastolic pressure of no waveform phase, the constant that K is 5~20.
As shown in figure 4, blood pressure acquisition unit 200 includes 210 He of diastolic pressure acquisition module in one embodiment of the application
Systolic pressure acquisition module 220, diastolic pressure acquisition module 210 and systolic pressure acquisition module 220 are measured with instantaneous coronary artery mean pressure
Unit 300 connects；Diastolic pressure acquisition module 210 is used to acquire the real-time diastolic pressure of patient, and systolic pressure acquisition module 220 is for adopting
Collect the real-time systolic pressure of patient；Instantaneous coronary artery mean pressure measuring unit 300 calculates instantaneous coronary artery according to the following two kinds formula and is averaged
Press Pw:
①Pw=Pd+(Ps-Pd)/n；
Wherein, PdIndicate the real-time diastolic pressure of no waveform phase, PsIndicate real-time systolic pressure of the patient without the waveform phase, n be 3~
10 constant；
②Pm=(2 × Pd+Ps)/3；
Pw=a × Pm；
Wherein, PdIndicate the real-time diastolic pressure of no waveform phase, PsIndicate real-time systolic pressure of the patient without the waveform phase, PmIt indicates
Real-time mean arterial pressure without the waveform phase, the constant that a is 0.5~1.5.
This application provides a kind of coronary analysis systems, comprising: instantaneous coronary artery of the above-mentioned measurement without the waveform phase is average
The device of pressure.
This application provides a kind of computer storage mediums, and above-mentioned measurement is realized when computer program is executed by processor
The method of instantaneous coronary artery mean pressure without the waveform phase.
Those skilled in the art will appreciate that various aspects of the invention can be implemented as system, method or calculating
Machine program product.Therefore, various aspects of the invention can be embodied in the following forms, it may be assumed that complete hardware embodiment,
The embodiment party combined in terms of complete Software Implementation (including firmware, resident software, microcode etc.) or hardware and software
Formula may be collectively referred to as circuit, " module " or " system " here.In addition, in some embodiments, various aspects of the invention are also
It can be implemented as the form of computer program product in one or more computer-readable medium, the computer-readable medium
In include computer-readable program code.The method of the embodiment of the present invention and/or the embodiment of system can be related to
Manually, automatically or in a manner of a combination thereof execute or complete selected task.
For example, the hardware realization that will can be used to execute the selected task of embodiment according to the present invention is chip or electricity
Road.As software, the selected task of embodiment according to the present invention can be embodied as using any appropriate operation by computer
Multiple software instructions that system executes.In an exemplary embodiment of the present invention, the root such as this paper is executed by data processor
According to one or more tasks of the exemplary embodiment of method and/or system, such as executing the computing platform of multiple instruction.
Optionally, which includes for storing instruction and/or the volatile storage of data and/or for storing instruction
And/or the non-volatile storage of data, for example, magnetic hard disk and/or removable medium.Optionally, a kind of network is also provided
Connection.Display and/or user input equipment, such as keyboard or mouse are optionally also provided.
Using one or more computer-readable any combination.Computer-readable medium can be computer-readable letter
Number medium or computer readable storage medium.Computer readable storage medium for example may be-but not limited to-electricity, magnetic,
Optical, electromagnetic, the system of infrared ray or semiconductor, device or device, or any above combination.Computer-readable storage medium
The more specific example (non-exhaustive listing) of matter will include the following terms:
Electrical connection, portable computer diskette, hard disk, random access memory (RAM) with one or more conducting wires, only
Read memory (ROM), erasable programmable read only memory (EPROM or flash memory), optical fiber, portable compact disc read only memory
(CD-ROM), light storage device, magnetic memory device or above-mentioned any appropriate combination.In this document, computer-readable
Storage medium can be it is any include or storage program tangible medium, the program can be commanded execution system, device or
Device use or in connection.
Computer-readable signal media may include in a base band or as carrier wave a part propagate data-signal,
Wherein carry computer-readable program code.The data-signal of this propagation can take various forms, including but unlimited
In electromagnetic signal, optical signal or above-mentioned any appropriate combination.Computer-readable signal media can also be that computer can
Any computer-readable medium other than storage medium is read, which can send, propagates or transmit and be used for
By the use of instruction execution system, device or device or program in connection.
The program code for including on computer-readable medium can transmit with any suitable medium, including but not limited to
Wirelessly, wired, optical cable, RF etc. or above-mentioned any appropriate combination.
For example, can be write with any combination of one or more programming languages for executing for each aspect of the present invention
Operation computer program code, Object-Oriented Programming Languages and the conventional process such as including Java, Smalltalk, C++
Programming language, such as " C " programming language or similar programming language.Program code can execute fully on the user computer,
It partly executes, executed as an independent software package on the user computer, part is on the user computer partially remote
It executes on journey computer or executes on a remote computer or server completely.In situations involving remote computers, far
Journey computer can pass through the network of any kind -- and user, which is connected to, including local area network (LAN) or wide area network (WAN)-calculates
Machine, or, it may be connected to outer computer (such as being connected using ISP by internet).
It should be appreciated that the combination of each box in each box and flowchart and or block diagram of flowchart and or block diagram,
It can be realized by computer program instructions.These computer program instructions can be supplied to general purpose computer, special purpose computer
Or the processor of other programmable data processing units, so that a kind of machine is produced, so that these computer program instructions exist
When being executed by computer or the processor of other programmable data processing units, produce in implementation flow chart and/or block diagram
One or more boxes specified in function action device.
Can also these computer program instructions store in computer-readable medium, these instruct so that computer,
Other programmable data processing units or other equipment work in a specific way, thus, it stores in computer-readable medium
Instruction just produces the instruction including function action specified in one or more boxes in implementation flow chart and/or block diagram
Manufacture (article of manufacture).
Computer program instructions can be also loaded into computer (for example, coronary analysis system) or other programmable numbers
According in processing equipment with promote in computer, other programmable data processing devices or other equipment execute sequence of operations step
Suddenly process is realized to generate computer, so that the instruction executed in computer, other programmable devices or other equipment provides
For realizing the process for the function action specified in flow chart and/or one or more diagram blocks.
Above specific example of the invention has carried out further the purpose of the present invention, technical scheme and beneficial effects
Be described in detail, it should be understood that be not intended to restrict the invention the above is only specific embodiments of the present invention, it is all
Within the spirit and principles in the present invention, any modification, equivalent substitution, improvement and etc. done should be included in protection of the invention
Within the scope of.
Claims (16)
1. a kind of method for measuring the instantaneous coronary artery mean pressure without the waveform phase characterized by comprising
Acquire the real-time pressure value of patient；
Determine patient's no waveform phase coronarius；
According to the determining patient no waveform phase coronarius, the pressure value of the no waveform phase is extracted, according to the blood
Pressure value calculates the instantaneous coronary artery mean pressure that synchronization is in the pressure value.
2. the method for instantaneous coronary artery mean pressure of the measurement without the waveform phase according to claim 1, which is characterized in that described true
The method for determining patient's no waveform phase coronarius includes:
Invasive pressure waveform within a cardiac cycle, to the invasive pressure before the systole phase after diastole again rich incisura
Reeb shape is patient's no waveform phase coronarius.
3. the method for instantaneous coronary artery mean pressure of the measurement without the waveform phase according to claim 1 or 2, which is characterized in that institute
Stating and acquiring the real-time pressure value of the patient includes: the real-time diastolic pressure for acquiring patient.
4. the method for instantaneous coronary artery mean pressure of the measurement without the waveform phase according to claim 3, which is characterized in that described
According to the pressure value, the formula that the instantaneous coronary artery mean pressure of synchronization is in the pressure value is calculated are as follows:
Pw=Pd+K；
Wherein, PwIndicate the instantaneous coronary artery mean pressure of no waveform phase, PdIndicate that the real-time diastolic pressure of no waveform phase, K are 5~20
Constant.
5. the method for instantaneous coronary artery mean pressure of the measurement without the waveform phase according to claim 4, which is characterized in that the K
For 10~12 constant.
6. the method for instantaneous coronary artery mean pressure of the measurement without the waveform phase according to claim 1 or 2, which is characterized in that institute
Stating and acquiring the real-time pressure value of the patient includes: the real-time diastolic pressure for acquiring patient and real-time systolic pressure.
7. the method for instantaneous coronary artery mean pressure of the measurement without the waveform phase according to claim 6, which is characterized in that described
According to the pressure value, the formula that the instantaneous coronary artery mean pressure of synchronization is in the pressure value is calculated are as follows:
Pw=Pd+(Ps-Pd)/n；
Wherein, PwIndicate the instantaneous coronary artery mean pressure of no waveform phase, PdIndicate the real-time diastolic pressure of no waveform phase, PsIndicate patient
Real-time systolic pressure without the waveform phase, the constant that n is 3~10.
8. the method for instantaneous coronary artery mean pressure of the measurement without the waveform phase according to claim 7, which is characterized in that the n
For 6~8 constant.
9. the method for instantaneous coronary artery mean pressure of the measurement without the waveform phase according to claim 6, which is characterized in that described
According to the pressure value, the formula that the instantaneous coronary artery mean pressure of synchronization is in the pressure value is calculated are as follows:
Pm=(2 × Pd+Ps)/3；
Pw=a × Pm；
Wherein, PwIndicate the instantaneous coronary artery mean pressure of no waveform phase, PmIndicate the real-time mean arterial pressure of no waveform phase, PdIt indicates
Real-time diastolic pressure without the waveform phase, PsIndicate the real-time systolic pressure of no waveform phase, the constant that a is 0.5~1.5.
10. the method for instantaneous coronary artery mean pressure of the measurement without the waveform phase according to claim 9, which is characterized in that a
For 0.8~0.9 constant.
11. a kind of method of measurement instantaneously without waveform ratio characterized by comprising
The method of described in any item instantaneous coronary artery mean pressures of the measurement without the waveform phase of claim 1~10；
According to the method for the instantaneous coronary artery mean pressure of the measurement without the waveform phase, the wink of the stenotic lesion distal end without the waveform phase is calculated
When coronary artery mean pressure PdwWith the instantaneous AoMP Pa of no waveform phasew；
According to the instantaneous coronary artery mean pressure PdwWith the instantaneous AoMP Paw, calculate instantaneously without waveform ratio iFR.
12. method of the measurement according to claim 11 instantaneously without waveform ratio, which is characterized in that if the no waveform
Phase calculates separately to obtain N number of PdwAnd Paw, then N number of instantaneous coronary artery mean pressure Pd is calculatedwAverage valueWith N number of instantaneous active
Arteries and veins mean pressure PawAverage value
According to average valueWithIt calculates instantaneously without waveform ratio iFR, specific formula are as follows:
13. a kind of device for described in any item instantaneous coronary artery mean pressures of the measurement without the waveform phase of claim 1~10,
It is characterized in that, comprising: no waveform identification unit, blood pressure acquisition unit and instantaneous coronary artery mean pressure measuring unit, the no waveform
Identification unit, the blood pressure acquisition unit are connect with the instantaneous coronary artery mean pressure measuring unit；
The no waveform identification unit is for determining patient's no waveform phase coronarius；
The blood pressure acquisition unit is used to acquire the pressure value of patient；
The instantaneous coronary artery mean pressure measuring unit is used to extract the blood according to determining patient's no waveform phase coronarius
The pressure value of the no waveform phase in acquisition unit is pressed, the wink without the waveform phase for being in synchronization with the pressure value is calculated
When coronary artery mean pressure.
14. the device of instantaneous coronary artery mean pressure of the measurement without the waveform phase according to claim 13, which is characterized in that described
Blood pressure acquisition unit is diastolic pressure acquisition module；The diastolic pressure acquisition module is used to acquire the real-time diastolic pressure of patient, described
Instantaneous coronary artery mean pressure measuring unit is according to formula Pw=Pd+ K is calculated, and obtains instantaneous coronary artery mean pressure Pw, wherein PdIndicate without
The real-time diastolic pressure of waveform phase, the constant that K is 5~20；Or
The blood pressure acquisition unit includes diastolic pressure acquisition module and systolic pressure acquisition module, the diastolic pressure acquisition module and institute
Systolic pressure acquisition module is stated to connect with the instantaneous coronary artery mean pressure measuring unit；The diastolic pressure acquisition module is for acquiring
The real-time diastolic pressure of patient, the systolic pressure acquisition module are used to acquire the real-time systolic pressure of patient；The instantaneous coronary artery is average
Measuring unit is pressed to calculate instantaneous coronary artery mean pressure P according to the following two kinds formulaw:
①Pw=Pd+(Ps-Pd)/n；
Wherein, PdIndicate the real-time diastolic pressure of no waveform phase, PsIndicate real-time systolic pressure of the patient without the waveform phase, n is 3~10
Constant；
②Pm=(2 × Pd+Ps)/3；
Pw=a × Pm；
Wherein, PdIndicate the real-time diastolic pressure of no waveform phase, PsIndicate real-time systolic pressure of the patient without the waveform phase, PmIndicate no wave
The real-time mean arterial pressure of shape phase, the constant that a is 0.5~1.5.
15. a kind of coronary analysis system characterized by comprising measurement described in claim 13 or 14 is without the waveform phase
Instantaneous coronary artery mean pressure device.
16. a kind of computer storage medium, which is characterized in that when computer program is executed by processor realize claim 1~
The method of 10 described in any item instantaneous coronary artery mean pressures of the measurement without the waveform phase.
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| CN201910763853.3A CN110353645A (en) | 2019-08-19 | 2019-08-19 | Measurement is without waveform phase pressure, ratio approach, device, system and storage medium |
| PCT/CN2019/115062 WO2021031355A1 (en) | 2019-08-19 | 2019-11-01 | Method and apparatus for measuring pressure and ratio in wave-free period, and system and storage medium |
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| WO2021031355A1 (en) * | 2019-08-19 | 2021-02-25 | 苏州润迈德医疗科技有限公司 | Method and apparatus for measuring pressure and ratio in wave-free period, and system and storage medium |
| CN112494020A (en) * | 2020-11-26 | 2021-03-16 | 苏州润迈德医疗科技有限公司 | Method for obtaining interested aorta pressure curve and storage medium |
| WO2022110095A1 (en) * | 2020-11-26 | 2022-06-02 | 苏州润迈德医疗科技有限公司 | Method for acquiring coronary artery vascular evaluation parameters and storage medium |
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| US20030032887A1 (en) * | 2001-08-09 | 2003-02-13 | Colin Corporation | Heartbeat synchronous information acquiring apparatus and pulse wave propagation velocity related information acquiring apparatus, blood pressure monitoring apparatus and preejection period measuring apparatus utilizing heartbeat synchronous information |
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| WO2021031355A1 (en) | 2021-02-25 |
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