CN110338867A - Electrostatic spinning Wound dressing and its processing method containing dihydroquercetin - Google Patents
Electrostatic spinning Wound dressing and its processing method containing dihydroquercetin Download PDFInfo
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- CN110338867A CN110338867A CN201910557893.2A CN201910557893A CN110338867A CN 110338867 A CN110338867 A CN 110338867A CN 201910557893 A CN201910557893 A CN 201910557893A CN 110338867 A CN110338867 A CN 110338867A
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- Prior art keywords
- layer
- electrostatic spinning
- fixed column
- wound
- dihydroquercetin
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- CXQWRCVTCMQVQX-LSDHHAIUSA-N (+)-taxifolin Chemical compound C1([C@@H]2[C@H](C(C3=C(O)C=C(O)C=C3O2)=O)O)=CC=C(O)C(O)=C1 CXQWRCVTCMQVQX-LSDHHAIUSA-N 0.000 title claims abstract description 43
- XCGZWJIXHMSSQC-UHFFFAOYSA-N dihydroquercetin Natural products OC1=CC2OC(=C(O)C(=O)C2C(O)=C1)c1ccc(O)c(O)c1 XCGZWJIXHMSSQC-UHFFFAOYSA-N 0.000 title claims abstract description 43
- 238000010041 electrostatic spinning Methods 0.000 title claims abstract description 38
- 238000003672 processing method Methods 0.000 title claims abstract description 12
- 239000010410 layer Substances 0.000 claims abstract description 96
- 239000000758 substrate Substances 0.000 claims abstract description 52
- 239000012790 adhesive layer Substances 0.000 claims abstract description 14
- 238000004080 punching Methods 0.000 claims abstract description 6
- 239000012528 membrane Substances 0.000 claims description 22
- 238000004078 waterproofing Methods 0.000 claims description 17
- 239000000243 solution Substances 0.000 claims description 16
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 14
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 14
- 238000009987 spinning Methods 0.000 claims description 14
- 239000011265 semifinished product Substances 0.000 claims description 10
- 238000000034 method Methods 0.000 claims description 8
- FXHOOIRPVKKKFG-UHFFFAOYSA-N N,N-Dimethylacetamide Chemical compound CN(C)C(C)=O FXHOOIRPVKKKFG-UHFFFAOYSA-N 0.000 claims description 7
- 229960000583 acetic acid Drugs 0.000 claims description 7
- 239000012362 glacial acetic acid Substances 0.000 claims description 7
- 239000011259 mixed solution Substances 0.000 claims description 7
- 239000000835 fiber Substances 0.000 claims description 6
- 239000011521 glass Substances 0.000 claims description 5
- 238000007731 hot pressing Methods 0.000 claims description 5
- 238000002513 implantation Methods 0.000 claims description 5
- 239000002904 solvent Substances 0.000 claims description 5
- 239000011347 resin Substances 0.000 claims description 4
- 229920005989 resin Polymers 0.000 claims description 4
- 239000004745 nonwoven fabric Substances 0.000 claims description 3
- 239000002344 surface layer Substances 0.000 claims description 3
- 239000000463 material Substances 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 206010052428 Wound Diseases 0.000 abstract description 62
- 208000027418 Wounds and injury Diseases 0.000 abstract description 62
- 241000894006 Bacteria Species 0.000 abstract description 8
- 230000029663 wound healing Effects 0.000 abstract description 6
- 230000009471 action Effects 0.000 abstract description 4
- 230000000844 anti-bacterial effect Effects 0.000 abstract description 4
- 210000000416 exudates and transudate Anatomy 0.000 abstract description 4
- 239000011148 porous material Substances 0.000 abstract description 4
- 238000007711 solidification Methods 0.000 abstract description 4
- 230000008023 solidification Effects 0.000 abstract description 4
- 230000004936 stimulating effect Effects 0.000 abstract description 4
- 239000012530 fluid Substances 0.000 description 11
- 238000010586 diagram Methods 0.000 description 3
- 239000000853 adhesive Substances 0.000 description 2
- 230000001070 adhesive effect Effects 0.000 description 2
- 235000011389 fruit/vegetable juice Nutrition 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 206010048038 Wound infection Diseases 0.000 description 1
- ZROGCCBNZBKLEL-MPRHSVQHSA-N astilbin Chemical compound O[C@@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@H]1O[C@H]1C(=O)C2=C(O)C=C(O)C=C2O[C@@H]1C1=CC=C(O)C(O)=C1 ZROGCCBNZBKLEL-MPRHSVQHSA-N 0.000 description 1
- 230000008952 bacterial invasion Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000011010 flushing procedure Methods 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000001764 infiltration Methods 0.000 description 1
- 230000008595 infiltration Effects 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 229940127554 medical product Drugs 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 230000003068 static effect Effects 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/08—Wound clamps or clips, i.e. not or only partly penetrating the tissue ; Devices for bringing together the edges of a wound
- A61B17/085—Wound clamps or clips, i.e. not or only partly penetrating the tissue ; Devices for bringing together the edges of a wound with adhesive layer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/00051—Accessories for dressings
- A61F13/00063—Accessories for dressings comprising medicaments or additives, e.g. odor control, PH control, debriding, antimicrobic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/02—Adhesive plasters or dressings
- A61F13/0276—Apparatus or processes for manufacturing adhesive dressings or bandages
- A61F13/0289—Apparatus or processes for manufacturing adhesive dressings or bandages manufacturing of adhesive dressings
-
- A61F13/05—
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/08—Wound clamps or clips, i.e. not or only partly penetrating the tissue ; Devices for bringing together the edges of a wound
- A61B17/085—Wound clamps or clips, i.e. not or only partly penetrating the tissue ; Devices for bringing together the edges of a wound with adhesive layer
- A61B2017/086—Wound clamps or clips, i.e. not or only partly penetrating the tissue ; Devices for bringing together the edges of a wound with adhesive layer having flexible threads, filaments, laces or wires, e.g. parallel threads, extending laterally from a strip, e.g. for tying to opposing threads extending from a similar strip
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F2013/00089—Wound bandages
- A61F2013/00246—Wound bandages in a special way pervious to air or vapours
- A61F2013/00255—Wound bandages in a special way pervious to air or vapours with pores
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F2013/00089—Wound bandages
- A61F2013/00314—Wound bandages with surface treatments
- A61F2013/00319—Wound bandages with surface treatments to make surface hydrophobic
Abstract
The invention discloses the electrostatic spinning Wound dressing containing dihydroquercetin, including for being fixed on skin surface two panels substrate layer, be set to the substrate layer one side adhesive layer, one of them described substrate layer is provided with the first fixed column on one side；The processing method that the present invention also proposes the electrostatic spinning Wound dressing containing dihydroquercetin, comprising the following steps: S1, by press machine with adhesive layer substrate layer on punching press breathable mesh, mesh diameter 0.5-1mm.This hair drives two substrate layers to squeeze wound by tension rope, make wound Natural closure, it requires no stitches, and the tunica fibrosa made of electrostatic spinning, there are complicated and numerous micro-pores, it being capable of antibacterial waterproof and breathable, inside is hydrophilic, wound exudate can be quickly absorbed, stimulating platelet solidification provides good environment for wound healing；Tunica fibrosa containing dihydroquercetin can kill bacterium, and be close to always with wound under the action of rubber elastic slice, the effective intrusion for placing bacterium.
Description
Technical field
The present invention relates to medical product extremely manufacturing method technical fields, more particularly to the Static Spinning containing dihydroquercetin
Silk Wound dressing and its processing method.
Background technique
When skin forms the small wound of shallow, scratch etc., Wound dressing can protect the surface of a wound not by bacterial invasion.But it is existing
Wound dressing, hydrophobicity cannot have both with gas permeability, and non-woven fabrics contacted for a long time with wound after be easy to happen adhesion, no
It conducive to the healing of wound, and is not easy to remove, brings pain to user.
Importantly, existing Wound dressing may be only available for the small surface of a wound, the surface of a wound of slightly larger point is just stitched
Needle brings great pain to patient, therefore present specification proposes a kind of electrostatic spinning surface of a wound containing dihydroquercetin
Dressing and its processing method.
Summary of the invention
The purpose of the present invention is to solve disadvantages existing in the prior art, and what is proposed contains the quiet of dihydroquercetin
Electrospun Wound dressing and its processing method drive two substrate layers to squeeze wound by tension rope, make wound certainly
So closure, requires no stitches, and the tunica fibrosa made of electrostatic spinning, has complicated and numerous micro-pores, can be antibacterial
Waterproof and breathable, inside is hydrophilic, can quickly absorb wound exudate, and stimulating platelet solidification provides good environment for wound healing；
Tunica fibrosa containing dihydroquercetin can kill bacterium, and be close to always with wound under the action of rubber elastic slice, effectively
Place the intrusion of bacterium；By setting waterproofing membrane, keep the Wound dressing washable, it is easy to use, patient is not influenced normally to be given birth to
It is living to use.
To achieve the goals above, present invention employs following technical solutions:
Electrostatic spinning Wound dressing containing dihydroquercetin, including the two panels substrate layer for being fixed on skin surface, setting
In the adhesive layer of the one side of the substrate layer, one of them described substrate layer is provided with the first fixed column on one side, described in another
Substrate layer is provided with the second fixed column on one side, is provided with tensioning chain between first fixed column and the second fixed column, and two
The rubber elastic slice in " arch bridge shape " is provided between the substrate layer, the lower end of the rubber elastic slice is fixedly connected with non-woven fabrics
Layer, the lower end surface of the nonwoven layer are provided with spongy layer, and a cylindrical cavity, and the cylindricality is arranged in the middle part of the spongy layer
Water-absorbing resin is filled in cavity, the spongy layer lower end is provided with tunica fibrosa, and the lower end surface of the tunica fibrosa offers S type
Chamber is rinsed, one end that the S type rinses chamber is provided with the vacuum suction connector communicated therewith.
Preferably, the surface of the substrate layer is evenly equipped with breathable mesh, and the breathable mesh is through substrate layer lower end surface
Adhesive layer.
Preferably, waterproofing membrane, the upper end of the waterproofing membrane and nonwoven layer are provided between two substrate layers
Face is glued.
Preferably, the tunica fibrosa is the nanometer spinning surface layer for being soaked with dihydroquercetin.
The processing method that the present invention also proposes the electrostatic spinning Wound dressing containing dihydroquercetin, comprising the following steps:
S1, by press machine on the substrate layer with adhesive layer punching press breathable mesh, mesh diameter 0.5-1mm, adjacent two
The distance between a breathable mesh is 0.5cm；
S2, first the second fixed column of fixed column is glued at the upper surface of two substrate layers respectively, and is made on two substrate layers
The position of first fixed column and the second fixed column is corresponding, then installs tensioning chain between the first fixed column and the first fixed column；
S3, rubber elastic slice and waterproofing membrane are pasted between two substrate layers, method is bonded using hot pressing, nonwoven layer is fixed on
The lower section of rubber elastic slice obtains semi-finished product A；
S4, the quality that the CA spinning solution that nano fibrous membrane molecular mass is 3000 is prepared using SS-2535H type electrostatic spinning apparatus
Score is determined as 20%, and solvent selects the mixed solution of acetone and DMAc or glacial acetic acid；
S5, by the CA spinning solution implantation glass syringe of clear and stand defoaming, adjust between syringe needle and receiving screen away from
It is 0.003-0.007mm/min from speed for 375px, is injected；
S6, high-voltage DC power supply anode connect syringe needle, cathode passes through receiving screen and is grounded, and voltage 15kV carries out electrostatic spinning, will
The tunica fibrosa spinned, which is placed into the dihydroquercetin solution that concentration is 1ppm, impregnates 2-4h, then takes out tunica fibrosa in room
It is dry under the conditions of temperature；
S7, the one side bonding spongy layer in the step S6 tunica fibrosa containing dihydroquercetin prepared, then will be bonded with fiber
The spongy layer of film is glued at the lower end of semi-finished product A.
Preferably, in the step S4, the mixed solution mass ratio of acetone and DMAc or glacial acetic acid is 2:1.
The invention has the following advantages:
1, it drives two substrate layers to squeeze wound by tension rope, makes wound Natural closure, require no stitches, and by quiet
Tunica fibrosa made of Electrospun has complicated and numerous micro-pores, can antibacterial waterproof and breathable, inside is hydrophilic, can be fast
Speed absorbs wound exudate, and stimulating platelet solidification provides good environment for wound healing；
2, the tunica fibrosa containing dihydroquercetin can kill bacterium, and be close to always with wound under the action of rubber elastic slice,
The effective intrusion for placing bacterium；
3, by setting waterproofing membrane, keep the Wound dressing washable, it is easy to use, patient's normal life use is not influenced；
4, pass through and S type flushing chamber and vacuum suction connector are set, in clinical use, when intervening the surface of a wound, S type rinses chamber will
Medical fluid injects cavernous body, and medical fluid is penetrated by the side wall that S type rinses chamber into spongy layer, is full of spongy layer, contacts simultaneously
The surface of a wound keeps intervening to the surface of a wound；
5, vacuum suction connector keep negative pressure, the juice of medical fluid and the surface of a wound in spongy layer is sucked, the medical fluid of injection and by
The medical fluid of suction keeps flow equilibrium, and then cleans to the surface of a wound.
Detailed description of the invention
Fig. 1 is the structural schematic diagram of the electrostatic spinning Wound dressing proposed by the present invention containing dihydroquercetin；
Fig. 2 is the top view of the electrostatic spinning Wound dressing proposed by the present invention containing dihydroquercetin；
Fig. 3 is structure enlargement diagram at the A in Fig. 1；
Fig. 4 is the structure schematic diagram of the electrostatic spinning Wound dressing proposed by the present invention containing dihydroquercetin.
In figure: 1 substrate layer, 2 first fixed columns, 3 rubber elastic slices, 4 tensioning chains, 5 second fixed columns, 6 breathable mesh, 7 fibres
It ties up film, 8 spongy layers, 9 water-absorbing resins, 10 waterproofing membranes, 11 nonwoven layers, 12 adhesive layers, 13 S types and rinses chamber.
Specific embodiment
In order to make the foregoing objectives, features and advantages of the present invention clearer and more comprehensible, with reference to the accompanying drawing to the present invention
Specific embodiment be described in detail.Many details are explained in the following description in order to fully understand this hair
It is bright.But the invention can be embodied in many other ways as described herein, those skilled in the art can be not
Similar improvement is done in the case where violating intension of the present invention, therefore the present invention is not limited to the specific embodiments disclosed below.
It should be noted that it can directly on the other element when element is referred to as " being fixed on " another element
Or there may also be elements placed in the middle.When an element is considered as " connection " another element, it, which can be, is directly connected to
To another element or it may be simultaneously present centering elements.Term as used herein " vertical ", " horizontal ", " left side ",
" right side " and similar statement for illustrative purposes only, are not meant to be the only embodiment.
Unless otherwise defined, all technical and scientific terms used herein and belong to technical field of the invention
The normally understood meaning of technical staff is identical.Term as used herein in the specification of the present invention is intended merely to description tool
The purpose of the embodiment of body, it is not intended that in the limitation present invention.Term " and or " used herein includes one or more phases
Any and all combinations of the listed item of pass.
Referring to Fig.1-4, the electrostatic spinning Wound dressing containing dihydroquercetin, including two for being fixed on skin surface
Plate substrate layer 1, be set to the substrate layer 1 one side adhesive layer 12, the surface of substrate layer 1 is evenly equipped with breathable mesh 6, gas-permeable nets
The adhesive layer 12 of 1 lower end surface of substrate layer is run through in hole 6.
One of substrate layer 1 is provided with the first fixed column 2 on one side, another substrate layer 1 is provided with second on one side
Fixed column 5 is provided with tensioning chain 4 between first fixed column 2 and the second fixed column 5, be provided between two substrate layers 1 in " arch
The rubber elastic slice 3 of bridge like ", the lower end of rubber elastic slice 3 are fixedly connected with nonwoven layer 11, are provided between two substrate layers 1
The upper surface of waterproofing membrane 10, waterproofing membrane 10 and nonwoven layer 11 is glued.
The lower end surface of nonwoven layer 11 is provided with spongy layer 8, and a cylindrical cavity is arranged in the middle part of spongy layer 8, and cylindricality is empty
Intracavitary to be filled with water-absorbing resin 9,8 lower end of spongy layer is provided with tunica fibrosa 7, and the lower end surface of tunica fibrosa 7 offers S type and rinses chamber
13, one end that the S type rinses chamber 13 is provided with the vacuum suction connector communicated therewith, and tunica fibrosa 7 is to be soaked with dihydroquercetin
Nanometer spinning surface layer.
Embodiment 1
The processing method that the present invention also proposes the electrostatic spinning Wound dressing containing dihydroquercetin, comprising the following steps:
S1, by press machine, punching press breathable mesh 6, mesh diameter 0.5mm are adjacent on the substrate layer 1 with adhesive layer 12
The distance between two breathable mesh 6 are 0.5cm；
S2,2 second fixed column 5 of the first fixed column is glued at the upper surface of two substrate layers 1 respectively, and makes two substrate layers 1
On the first fixed column 2 and the second fixed column 5 position it is corresponding, then installed between the first fixed column 2 and the first fixed column 5
Tensioning chain 4；
S3, rubber elastic slice 3 and waterproofing membrane 10 are pasted between two substrate layers 1, method is bonded using hot pressing, by nonwoven layer 11
It is fixed on the lower section of rubber elastic slice 3, obtains semi-finished product A；
S4, the quality that the CA spinning solution that nano fibrous membrane molecular mass is 3000 is prepared using SS-2535H type electrostatic spinning apparatus
Score is determined as 20%, and solvent selects the mixed solution of acetone and DMAc or glacial acetic acid；
S5, by the CA spinning solution implantation glass syringe of clear and stand defoaming, adjust between syringe needle and receiving screen away from
It is 0.003mm/min from speed for 375px, is injected；
S6, high-voltage DC power supply anode connect syringe needle, cathode passes through receiving screen and is grounded, and voltage 15kV carries out electrostatic spinning, will
The tunica fibrosa 7 spinned, which is placed into the dihydroquercetin solution that concentration is 1ppm, impregnates 2h, then takes out tunica fibrosa 7 in room
It is dry under the conditions of temperature；
S7, the one side bonding spongy layer 8 in the step S7 tunica fibrosa 7 containing dihydroquercetin prepared, then will be bonded with fibre
The spongy layer 8 of dimension film 7 is glued at the lower end of semi-finished product A.
Embodiment 2
The processing method that the present invention also proposes the electrostatic spinning Wound dressing containing dihydroquercetin, comprising the following steps:
S1, by press machine, punching press breathable mesh 6, mesh diameter 0.7mm are adjacent on the substrate layer 1 with adhesive layer 12
The distance between two breathable mesh 6 are 0.5cm；
S2,2 second fixed column 5 of the first fixed column is glued at the upper surface of two substrate layers 1 respectively, and makes two substrate layers 1
On the first fixed column 2 and the second fixed column 5 position it is corresponding, then installed between the first fixed column 2 and the first fixed column 5
Tensioning chain 4；
S3, rubber elastic slice 3 and waterproofing membrane 10 are pasted between two substrate layers 1, method is bonded using hot pressing, by nonwoven layer 11
It is fixed on the lower section of rubber elastic slice 3, obtains semi-finished product A；
S4, the quality that the CA spinning solution that nano fibrous membrane molecular mass is 3000 is prepared using SS-2535H type electrostatic spinning apparatus
Score is determined as 20%, and solvent selects the mixed solution of acetone and DMAc or glacial acetic acid；
S5, by the CA spinning solution implantation glass syringe of clear and stand defoaming, adjust between syringe needle and receiving screen away from
It is 0.005mm/min from speed for 375px, is injected；
S6, high-voltage DC power supply anode connect syringe needle, cathode passes through receiving screen and is grounded, and voltage 15kV carries out electrostatic spinning, will
The tunica fibrosa 7 spinned, which is placed into the dihydroquercetin solution that concentration is 1ppm, impregnates 3h, then takes out tunica fibrosa 7 in room
It is dry under the conditions of temperature；
S7, the one side bonding spongy layer 8 in the step S7 tunica fibrosa 7 containing dihydroquercetin prepared, then will be bonded with fibre
The spongy layer 8 of dimension film 7 is glued at the lower end of semi-finished product A.
Embodiment 3
The processing method that the present invention also proposes the electrostatic spinning Wound dressing containing dihydroquercetin, comprising the following steps:
S1, by press machine on the substrate layer 1 with adhesive layer 12 punching press breathable mesh 6, mesh diameter 1mm, adjacent two
The distance between a breathable mesh 6 is 0.5cm；
S2,2 second fixed column 5 of the first fixed column is glued at the upper surface of two substrate layers 1 respectively, and makes two substrate layers 1
On the first fixed column 2 and the second fixed column 5 position it is corresponding, then installed between the first fixed column 2 and the first fixed column 5
Tensioning chain 4；
S3, rubber elastic slice 3 and waterproofing membrane 10 are pasted between two substrate layers 1, method is bonded using hot pressing, by nonwoven layer 11
It is fixed on the lower section of rubber elastic slice 3, obtains semi-finished product A；
S4, the quality that the CA spinning solution that nano fibrous membrane molecular mass is 3000 is prepared using SS-2535H type electrostatic spinning apparatus
Score is determined as 20%, and solvent selects the mixed solution of acetone and DMAc or glacial acetic acid；
S5, by the CA spinning solution implantation glass syringe of clear and stand defoaming, adjust between syringe needle and receiving screen away from
It is 0.007mm/min from speed for 375px, is injected；
S6, high-voltage DC power supply anode connect syringe needle, cathode passes through receiving screen and is grounded, and voltage 15kV carries out electrostatic spinning, will
The tunica fibrosa 7 spinned, which is placed into the dihydroquercetin solution that concentration is 1ppm, impregnates 4h, then takes out tunica fibrosa 7 in room
It is dry under the conditions of temperature；
S7, the one side bonding spongy layer 8 in the step S7 tunica fibrosa 7 containing dihydroquercetin prepared, then will be bonded with fibre
The spongy layer 8 of dimension film 7 is glued at the lower end of semi-finished product A.
In the present invention, drives two substrate layers to squeeze wound by tension rope, make wound Natural closure, without seam
Needle, and tunica fibrosa 7 made of electrostatic spinning have complicated and numerous micro-pores, can antibacterial waterproof and breathable, inside
It is hydrophilic, wound exudate can be quickly absorbed, stimulating platelet solidification provides good environment for wound healing；Contain dihydro quercitrin
The tunica fibrosa 7 of element can kill bacterium, and be close to always with wound under the action of rubber elastic slice 3, effective placement bacterium
Intrusion；By setting waterproofing membrane 10, keep the Wound dressing washable, it is easy to use, patient's normal life use is not influenced；It is logical
It crosses setting S type and rinses chamber 13 and vacuum suction connector, in clinical use, when intervening the surface of a wound, S type rinses chamber 13 for medical fluid
Cavernous body is injected, medical fluid is penetrated by the side wall that S type rinses chamber 13 into spongy layer 8, is full of spongy layer 8, is contacted simultaneously
The surface of a wound keeps intervening to the surface of a wound；It should be noted that waterproofing membrane 10 the surface of a wound formed one sealing space, by the surface of a wound with
External environment isolation, while the infiltration micropore between waterproofing membrane 10 and spongy layer 8 can be such that the medical fluid in spongy layer 8 enters
In tunica fibrosa 7, vacuum suction connector keeps negative pressure, the juice of medical fluid and the surface of a wound in spongy layer 8 is sucked, the medical fluid of injection
Flow equilibrium is kept with the medical fluid being sucked out, and then the surface of a wound is cleaned.
In order to examine the effect of the electrostatic spinning Wound dressing proposed in the present invention containing dihydroquercetin, will use
The electrostatic spinning Wound dressing for containing dihydroquercetin and adhesive bandage common on the market of present invention process production are as experiment
Group, chooses 200 patients, and stochastic averagina is divided into two groups, is tested
| Use the electrostatic spinning Wound dressing containing dihydroquercetin | It is applicable in surface of a wound size/cm | Wound healing time/d | Whether wound occurs number of the infected/total number of persons | Single product cost/$ |
| Embodiment 1 | 1.0-5.0 | 3 | 1.0% | 1 |
| Embodiment 2 | 1.0-5.0 | 2 | 0.5% | 1 |
| Embodiment 3 | 1.0-5.0 | 8 | 2.5% | 1 |
| Common adhesive bandage | 1.0-2.0 | 7 | 10.0% | 0.5 |
By above-mentioned experimental data it is found that the electrostatic spinning Wound dressing containing dihydroquercetin of application this programme, is applicable in the surface of a wound
It is bigger, it is not necessarily to patient's suture needle, using the electrostatic spinning Wound dressing containing dihydroquercetin of embodiment 3, wound healing time
Greatly shorten, wound infection rate is minimum, is worthy to be popularized.
The foregoing is only a preferred embodiment of the present invention, but scope of protection of the present invention is not limited thereto,
Anyone skilled in the art in the technical scope disclosed by the present invention, according to the technique and scheme of the present invention and its
Inventive concept is subject to equivalent substitution or change, should be covered by the protection scope of the present invention.
Claims (6)
1. the electrostatic spinning Wound dressing containing dihydroquercetin, which is characterized in that including two for being fixed on skin surface
Plate substrate layer (1), be set to the substrate layer (1) one side adhesive layer (12), one of them substrate layer (1) is set on one side
The first fixed column (2) are equipped with, another substrate layer (1) is provided with the second fixed column (5) on one side, first fixed column
(2) it is provided with tensioning chain (4), is provided between two substrate layers (1) in " arch bridge shape " between the second fixed column (5)
The lower end of rubber elastic slice (3), the rubber elastic slice (3) is fixedly connected with nonwoven layer (11), the nonwoven layer (11)
Lower end surface is provided with spongy layer (8), and a cylindrical cavity, and filling in the cylindrical cavity is arranged in the middle part of the spongy layer (8)
Have water-absorbing resin (9), spongy layer (8) lower end is provided with tunica fibrosa (7), and the lower end surface of the tunica fibrosa (7) offers S
Type rinses chamber (13), and one end that the S type rinses chamber (13) is provided with the vacuum suction connector communicated therewith.
2. the electrostatic spinning Wound dressing according to claim 1 containing dihydroquercetin, which is characterized in that the substrate
The surface of layer (1) is evenly equipped with breathable mesh (6), and the breathable mesh (6) runs through the adhesive layer (12) of substrate layer (1) lower end surface.
3. the electrostatic spinning Wound dressing according to claim 1 containing dihydroquercetin, which is characterized in that described in two
It is provided between substrate layer (1) waterproofing membrane (10), the upper surface of the waterproofing membrane (10) and nonwoven layer (11) is glued.
4. the electrostatic spinning Wound dressing according to claim 1 containing dihydroquercetin, which is characterized in that the fiber
Film (7) is the nanometer spinning surface layer for being soaked with dihydroquercetin.
5. the processing method of the electrostatic spinning Wound dressing containing dihydroquercetin, which comprises the following steps:
S1, pass through press machine punching press breathable mesh (6), mesh diameter 0.5- on the substrate layer (1) with adhesive layer (12)
1mm, the distance between two neighboring breathable mesh (6) are 0.5cm；
S2, (2) second fixed column (5) of the first fixed column is glued at the upper surface of two substrate layers (1) respectively, and makes two bases
The first fixed column (2) on material layer (1) is corresponding with the position of the second fixed column (5), then solid in the first fixed column (2) and first
Tensioning chain (4) are installed between fixed column (5)；
S3, rubber elastic slice (3) and waterproofing membrane (10) are pasted between two substrate layers 1, method is bonded using hot pressing, by non-woven fabrics
Layer (11) is fixed on the lower section of rubber elastic slice (3), obtains semi-finished product A；
S4, the quality that the CA spinning solution that nano fibrous membrane molecular mass is 3000 is prepared using SS-2535H type electrostatic spinning apparatus
Score is determined as 20%, and solvent selects the mixed solution of acetone and DMAc or glacial acetic acid；
S5, by the CA spinning solution implantation glass syringe of clear and stand defoaming, adjust between syringe needle and receiving screen away from
It is 0.003-0.007mm/min from speed for 375px, is injected；
S6, high-voltage DC power supply anode connect syringe needle, cathode passes through receiving screen and is grounded, and voltage 15kV carries out electrostatic spinning, will
The tunica fibrosa (7) spinned, which is placed into the dihydroquercetin solution that concentration is 1ppm, impregnates 2-4h, then takes tunica fibrosa (7)
It dries at room temperature out；
S7, the one side bonding spongy layer 8 in the step S7 tunica fibrosa 7 containing dihydroquercetin prepared, then will be bonded with fibre
The spongy layer (8) of dimension film (7) is glued at the lower end of semi-finished product A.
6. the processing method of the electrostatic spinning Wound dressing according to claim 5 containing dihydroquercetin, feature exist
In in the step S4, the mixed solution mass ratio of acetone and DMAc or glacial acetic acid is 2:1.
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Application publication date: 20191018 |