CN110327893A - One kind is for bilirubin blood purification polymer microsphere and preparation method thereof - Google Patents
One kind is for bilirubin blood purification polymer microsphere and preparation method thereof Download PDFInfo
- Publication number
- CN110327893A CN110327893A CN201910487040.6A CN201910487040A CN110327893A CN 110327893 A CN110327893 A CN 110327893A CN 201910487040 A CN201910487040 A CN 201910487040A CN 110327893 A CN110327893 A CN 110327893A
- Authority
- CN
- China
- Prior art keywords
- blood purification
- polymer microsphere
- preparation
- bilirubin
- microballoon
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
- B01J13/02—Making microcapsules or microballoons
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
- B01J13/02—Making microcapsules or microballoons
- B01J13/06—Making microcapsules or microballoons by phase separation
- B01J13/14—Polymerisation; cross-linking
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/22—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising organic material
- B01J20/26—Synthetic macromolecular compounds
- B01J20/265—Synthetic macromolecular compounds modified or post-treated polymers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
- B01J20/28014—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their form
- B01J20/28016—Particle form
- B01J20/28021—Hollow particles, e.g. hollow spheres, microspheres or cenospheres
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F212/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an aromatic carbocyclic ring
- C08F212/02—Monomers containing only one unsaturated aliphatic radical
- C08F212/04—Monomers containing only one unsaturated aliphatic radical containing one ring
- C08F212/06—Hydrocarbons
- C08F212/08—Styrene
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F8/00—Chemical modification by after-treatment
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2220/00—Aspects relating to sorbent materials
- B01J2220/40—Aspects relating to the composition of sorbent or filter aid materials
- B01J2220/48—Sorbents characterised by the starting material used for their preparation
- B01J2220/4806—Sorbents characterised by the starting material used for their preparation the starting material being of inorganic character
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2220/00—Aspects relating to sorbent materials
- B01J2220/40—Aspects relating to the composition of sorbent or filter aid materials
- B01J2220/48—Sorbents characterised by the starting material used for their preparation
- B01J2220/4812—Sorbents characterised by the starting material used for their preparation the starting material being of organic character
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Analytical Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- General Chemical & Material Sciences (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- External Artificial Organs (AREA)
Abstract
The invention discloses one kind for bilirubin blood purification polymer microsphere and preparation method thereof, by the way that dispersant solution and organic phase to be stirred, carries out polymerization reaction using gradient increased temperature, obtains polymer；Polymer is scattered in reaction dissolvent, and liquor ferri trichloridi is added, and reaction obtains the microballoon of chloromethylation；The microballoon of chloromethylation is scattered in addition trimethylamine saturated aqueous solution in ethanol water and reacts to obtain quaternary ammoniated microballoon；Quaternary ammoniated microballoon is dispersed in water, and modifying agent is added, and insulation reaction 3h ~ 5h is obtained for bilirubin blood purification polymer microsphere.The present invention is prepared that aperture is big, adsorption rate is high, selectivity is high for bilirubin blood purification polymer microsphere by forming compatible layer.
Description
Technical field
The present invention relates to one kind for bilirubin blood purification polymer microsphere and preparation method thereof, belongs to polymer adsorption
Technical field of material.
Background technique
Bilirubin is one kind of BILE PIGMENTS, is the primary pigments in human bile, including total bilirubin, bilirubin direct and
Connect bilirubin.Excessively high bilirubin is a kind of common disease, will lead to dead generation.Current most effective treatment method is to pass through blood
Liquid adsorbent adsorbs excessive bilirubin.Conventional blood absorbence is only used for the absorption of blood plasma bilirubin, for complete
It will lead to blood clotting when blood.
Publication No. discloses micro- for the polystyrene-divinylbenzene of blood purification for the patent of invention of CN101612543
The polymer microsphere of the preparation of ball, preparation is synthesized using seed emulsion swollen-state polymerization method, and used seed microballoon is diameter
For 6-8 microns of larger diameter linear polystyrene microballoon, used monomer and crosslinking agent are respectively styrene, divinyl
Benzene.Used pore-foaming agent be toluene, ethylbenzene, phthalic acid lipid, normal heptane, normal octane, n-heptanol or above-mentioned substance it
Between mixture.Prepared polymer microsphere is used for place to go bilirubin for blood purification.The features such as stable mechanical strength,
Preparation process yield is high.But in use, compared with high adsorption capacity requirement and it is highly selective under conditions of cannot still reach
To requirement, need to prepare biocompatible material to solve blood clotting problems, the stability of wrapping biological compatible layer is always not
It is too perfect, therefore it is the key that solve bilirubin adsorption that biocompatibility layer and material itself, which are formed integrated adsorbent material,.
Summary of the invention
The technical problem to be solved by the present invention is to overcome the deficiencies of existing technologies, provide a kind of net for bilirubin blood
Change polymer microsphere and preparation method thereof, by forming compatible layer, the use that aperture is big, adsorption rate is high, selectivity is high is prepared
In bilirubin blood purification polymer microsphere.
Above-mentioned technical purpose of the invention has the technical scheme that
A kind of preparation method for bilirubin blood purification polymer microsphere, comprising the following steps:
(1) methyl blue aqueous solution is added in polyvinyl alcohol water solution, is configured to dispersant solution；
(2) benzoyl peroxide, pore-foaming agent, styrene and divinylbenzene are mixed, is configured to organic phase；
(3) dispersant solution of above-mentioned preparation and organic phase are stirred, polymerization reaction is carried out using gradient increased temperature, is gathered
Close object；
(4) it disperses polymer in reaction dissolvent, keeping temperature of reaction system is 10 DEG C ~ 30 DEG C, is slowly added to ferric trichloride
Solution after addition, is warming up to 40 DEG C ~ 60 DEG C reaction 5h ~ 8h, obtains the microballoon of chloromethylation；
(5) it disperses the microballoon of chloromethylation in ethanol water, solid content is 10% ~ 30%, and it is water-soluble that trimethylamine saturation is added
Liquid keeps system temperature at 10 DEG C ~ 40 DEG C, reacts for 24 hours ~ 48h, obtains quaternary ammoniated microballoon；
(6) quaternary ammoniated microballoon is dispersed in water, makes system solid content 10% ~ 20%, be warming up to 70 DEG C ~ 80 DEG C, addition changes
Property agent, insulation reaction 3h ~ 5h obtains for bilirubin blood purification polymer microsphere.
Preferably, the pore-foaming agent be include component A, B component；The component A is in liquid alcohol of the carbon atom number greater than 6
One kind, the B component is one of n-butyl ether, normal hexane, normal heptane or phthalic acid ester.
Preferably, the mass ratio of the component A and B component be 4:1.
Preferably, the gradient increased temperature is to rise to 60 DEG C by 0.5h, keeps the temperature 1h；Using 0.5h, 70 DEG C are risen to, is protected
Warm 2h；80 DEG C are risen to finally by 0.5h, keeps the temperature 6h.
By using above-mentioned technical proposal, gathered using the heating mode of mitigation so that polymerization reaction progress is more complete
It is right higher, it is more advantageous to the preparation of subsequent material.
Preferably, the reaction dissolvent in the step (4) is what dimethoxym ethane, paraformaldehyde, water and chlorosulfonic acid were mixed to form
Mixed solution.
Preferably, the modifying agent is one of hydroxy-ethyl acrylate or vinyl pyrrolidone.
The present invention also provides one kind to be used for bilirubin blood purification polymer microsphere, by any one of claim 1 ~ 6 institute
A kind of preparation method for bilirubin blood purification polymer microsphere stated is prepared.
Preferably, the microspherulite diameter is 300 μm ~ 1.2 mm.
In conclusion the invention has the following advantages:
(1) present invention by copolymerization be prepared with biocompatibility layer, macropore, quaternary ammoniated inner surface highly selective bilirubin
Blood purification polymer microsphere, the bilirubin blood purification polymer microsphere of preparation remain height while absorbing bilirubin
The albumin of concentration, it is strong for the selection absorbability of bilirubin, and blood homeostasis will not be destroyed；Moreover, relative to commercial product,
The loss late of the bilirubin blood purification polymer microsphere of preparation is small；
(2) preparation method for bilirubin blood purification polymer microsphere of the invention is not necessarily to secondary embedding, passes through copolymerization
The preparation for completing biocompatibility layer, reduces processing step, saves the preparation cost.
Detailed description of the invention
Fig. 1 is the structural schematic diagram for bilirubin blood purification polymer microsphere of the invention；
Fig. 2 is the microscope figure for bilirubin blood purification polymer microsphere of the invention；
Fig. 3 is the graph of pore diameter distribution for bilirubin blood purification polymer microsphere of the invention.
Specific embodiment
The invention will be further described below.Following embodiment is only used for clearly illustrating technical side of the invention
Case, and not intended to limit the protection scope of the present invention.
A kind of preparation method for bilirubin blood purification polymer microsphere, comprising the following steps:
(1) methyl blue aqueous solution is added in polyvinyl alcohol water solution, is configured to dispersant solution；
(2) benzoyl peroxide, pore-foaming agent, styrene and divinylbenzene are mixed, is configured to organic phase；
(3) dispersant solution of above-mentioned preparation and organic phase are stirred, polymerization reaction is carried out using gradient increased temperature, is gathered
Close object；
(4) it disperses polymer in reaction dissolvent, keeping temperature of reaction system is 10 DEG C ~ 30 DEG C, is slowly added to ferric trichloride
Solution after addition, is warming up to 40 DEG C ~ 60 DEG C reaction 5h ~ 8h, obtains the microballoon of chloromethylation；
(5) it disperses the microballoon of chloromethylation in ethanol water, solid content is 10% ~ 30%, and it is water-soluble that trimethylamine saturation is added
Liquid keeps system temperature at 10 DEG C ~ 40 DEG C, reacts for 24 hours ~ 48h, obtains quaternary ammoniated microballoon；
(6) quaternary ammoniated microballoon is dispersed in water, makes system solid content 10% ~ 20%, be warming up to 70 DEG C ~ 80 DEG C, addition changes
Property agent, insulation reaction 3h ~ 5h obtains for bilirubin blood purification polymer microsphere.
Obtained microspherulite diameter is 300 μm ~ 1.2 mm, and the structure of obtained bilirubin blood purification polymer microsphere is shown
It is intended to as shown in Figure 1, the microscope figure of obtained bilirubin blood purification polymer microsphere is as shown in Fig. 2, can from figure
Out, the microballoon obtained is the smooth regular spherical in surface, the graph of pore diameter distribution of obtained bilirubin blood purification polymer microsphere
As shown in figure 3, as can be seen from the figure aperture is mainly distributed on 10 ~ 100nm, aperture is relatively uniform, can be used for adsorbing bilirubin.
Embodiment 1
A kind of preparation method for bilirubin blood purification polymer microsphere, comprising the following steps:
(1) 50g polyvinyl alcohol is added in 1L water and stirs to get polyvinyl alcohol water solution, it is dense that mass percent is added thereto
Degree is 0.1% methylene blue aqueous solution 16ml, is configured to dispersant solution；
It (2) is 60% divinylbenzene, 35g benzene by 0.4g benzoyl peroxide, n-nonyl alcohol 32g, n-butyl ether 8g, 40g mass fraction
Ethylene is uniformly mixed, and is configured to organic phase；
(3) dispersant solution of above-mentioned preparation and organic phase are stirred, rise to 60 DEG C by 0.5h using gradient increased temperature,
Keep the temperature 1h；Using 0.5h, 70 DEG C are risen to, keeps the temperature 2h；80 DEG C are risen to finally by 0.5h, keeps the temperature 6h, carries out polymerization reaction, instead
After answering, product is filtered, and is washed 3 times, is obtained 60g polymer；
(4) (180 ml dimethoxym ethanes, 4.05 g paraformaldehydes, 51.9 g water, 192 are dispersed in mixed solution by 60g polymer
Agitated be uniformly mixed of ml chlorosulfonic acid is prepared), keeping system temperature is 10 DEG C, and being slowly added to 100g mass fraction is 50%
Ferric chloride aqueous solutions, after addition, be warming up to 40 DEG C of reaction 5h, obtain the microballoon of chloromethylation；
(5) it disperses the microballoon of 67g chloromethylation in the ethanol water that 250ml mass fraction is 50%, solid content is
21%, 150ml trimethylamine saturated aqueous solution is added, keeps system temperature at 10 DEG C, reacts 48h, obtains quaternary ammoniated microballoon；
(6) it disperses the quaternary ammoniated microballoon of 80g in 720ml water, makes system solid content 10%, be warming up to 70 DEG C, 5g third is added
Olefin(e) acid hydroxyl ethyl ester, insulation reaction 3h are obtained for bilirubin blood purification polymer microsphere.
After taking 1ml micro-sphere material to adsorb two hours in blood plasma, blood plasma bilirubin and albumin residual quantity are surveyed, is surveyed
Test result is as shown in table 1.
Table 1
| Title | Bilirubin (mmol/L) | Adsorption rate (%) | Albumin residual concentration (mg/L) | Loss late (%) |
| Prepare product | 0.11 | 71 | 46.1 | 7.2 |
| Commercial product | 0.19 | 50 | 45.6 | 8.2 |
| Blood plasma blank sample | 0.38 | / | 49.7 | / |
Embodiment 2
A kind of preparation method for bilirubin blood purification polymer microsphere, comprising the following steps:
(1) 50g polyvinyl alcohol is added in 1L water and stirs to get polyvinyl alcohol water solution, it is dense that mass percent is added thereto
Degree is 0.1% methylene blue aqueous solution 16ml, is configured to dispersant solution；
It (2) is 60% divinylbenzene, 55g benzene by 0.4g benzoyl peroxide, n-heptanol 32g, normal hexane 8g, 40g mass fraction
Ethylene is uniformly mixed, and is configured to organic phase；
(3) dispersant solution of above-mentioned preparation and organic phase are stirred, rise to 60 DEG C by 0.5h using gradient increased temperature,
Keep the temperature 1h；Using 0.5h, 70 DEG C are risen to, keeps the temperature 2h；80 DEG C are risen to finally by 0.5h, keeps the temperature 6h, carries out polymerization reaction, instead
After answering, product is filtered, and is washed 3 times, is obtained 70g polymer；
(4) (200 ml dimethoxym ethanes, 5.25 g paraformaldehydes, 62.5 g water, 206ml are dispersed in mixed solution by 70g polymer
Agitated be uniformly mixed of chlorosulfonic acid is prepared), keeping system temperature is 30 DEG C, and being slowly added to 120g mass fraction is 50%
Ferric chloride aqueous solutions after addition, are warming up to 60 DEG C of reaction 8h, obtain the microballoon of chloromethylation；
(5) it disperses the microballoon of 80g chloromethylation in the ethanol water that 190ml mass fraction is 50%, solid content is
30%, 160ml trimethylamine saturated aqueous solution is added, keeps system temperature at 40 DEG C, reaction for 24 hours, obtains quaternary ammoniated microballoon；
(6) it disperses the quaternary ammoniated microballoon of 86g in 345ml water, makes system solid content 20%, be warming up to 80 DEG C, 5g second is added
Vinyl pyrrolidone, insulation reaction 5h are obtained for bilirubin blood purification polymer microsphere.
After taking 1ml micro-sphere material to adsorb two hours in blood plasma, blood plasma bilirubin and albumin residual quantity are surveyed, is surveyed
Test result is as shown in table 2.
Table 2
| Title | Bilirubin (mmol/L) | Adsorption rate (%) | Albumin residual concentration (mg/L) | Loss late (%) |
| Prepare product | 0.09 | 76 | 46.6 | 7.0 |
| Commercial product | 0.19 | 50 | 45.6 | 8.2 |
| Blood plasma blank sample | 0.38 | / | 49.7 | / |
As can be seen that the bilirubin blood purification polymer microsphere of preparation is while absorbing bilirubin from table 1, table 2, retain
The albumin of high concentration, it is for the selection absorbability of bilirubin strong, and blood homeostasis will not be destroyed；Moreover, relative to commercially available
The loss late of product, the bilirubin blood purification polymer microsphere of preparation is small.
The above is only a preferred embodiment of the present invention, protection scope of the present invention is not limited merely to above-mentioned implementation
Example, all technical solutions belonged under thinking of the present invention all belong to the scope of protection of the present invention.It should be pointed out that for the art
Those of ordinary skill for, several improvements and modifications without departing from the principles of the present invention, these improvements and modifications
It should be regarded as protection scope of the present invention.
Claims (8)
1. a kind of preparation method for bilirubin blood purification polymer microsphere, characterized in that the following steps are included:
(1) methyl blue aqueous solution is added in polyvinyl alcohol water solution, is configured to dispersant solution；
(2) benzoyl peroxide, pore-foaming agent, styrene and divinylbenzene are mixed, is configured to organic phase；
(3) dispersant solution of above-mentioned preparation and organic phase are stirred, polymerization reaction is carried out using gradient increased temperature, is gathered
Close object；
(4) it disperses polymer in reaction dissolvent, keeping temperature of reaction system is 10 DEG C ~ 30 DEG C, is slowly added to ferric trichloride
Solution after addition, is warming up to 40 DEG C ~ 60 DEG C reaction 5h ~ 8h, obtains the microballoon of chloromethylation；
(5) it disperses the microballoon of chloromethylation in ethanol water, solid content is 10% ~ 30%, and it is water-soluble that trimethylamine saturation is added
Liquid keeps system temperature at 10 DEG C ~ 40 DEG C, reacts for 24 hours ~ 48h, obtains quaternary ammoniated microballoon；
(6) quaternary ammoniated microballoon is dispersed in water, makes system solid content 10% ~ 20%, be warming up to 70 DEG C ~ 80 DEG C, addition changes
Property agent, insulation reaction 3h ~ 5h obtains for bilirubin blood purification polymer microsphere.
2. a kind of preparation method for bilirubin blood purification polymer microsphere according to claim 1, characterized in that
The pore-foaming agent be include component A, B component；
The component A is one of the liquid alcohol that carbon atom number is greater than 6, and the B component is n-butyl ether, normal hexane, normal heptane
Or one of phthalic acid ester.
3. a kind of preparation method for bilirubin blood purification polymer microsphere according to claim 2, characterized in that
The mass ratio of the component A and B component be 4:1.
4. a kind of preparation method for bilirubin blood purification polymer microsphere according to claim 1, characterized in that
The gradient increased temperature is to rise to 60 DEG C by 0.5h, keeps the temperature 1h；Using 0.5h, 70 DEG C are risen to, keeps the temperature 2h；Finally by
0.5h rises to 80 DEG C, keeps the temperature 6h.
5. a kind of preparation method for bilirubin blood purification polymer microsphere according to claim 1, characterized in that
Reaction dissolvent in the step (4) is the mixed solution that dimethoxym ethane, paraformaldehyde, water and chlorosulfonic acid are mixed to form.
6. a kind of preparation method for bilirubin blood purification polymer microsphere according to claim 1, characterized in that
The modifying agent is one of hydroxy-ethyl acrylate or vinyl pyrrolidone.
7. one kind is used for bilirubin blood purification polymer microsphere, described in any item a kind of red for gallbladder by claim 1 ~ 6
The preparation method of plain blood purification polymer microsphere is prepared.
8. according to claim 7 a kind of for bilirubin blood purification polymer microsphere, characterized in that the framboid
Diameter is 300 μm ~ 1.2 mm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910487040.6A CN110327893A (en) | 2019-06-05 | 2019-06-05 | One kind is for bilirubin blood purification polymer microsphere and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910487040.6A CN110327893A (en) | 2019-06-05 | 2019-06-05 | One kind is for bilirubin blood purification polymer microsphere and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN110327893A true CN110327893A (en) | 2019-10-15 |
Family
ID=68140803
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910487040.6A Pending CN110327893A (en) | 2019-06-05 | 2019-06-05 | One kind is for bilirubin blood purification polymer microsphere and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN110327893A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110787775A (en) * | 2019-10-31 | 2020-02-14 | 武汉瑞法医疗器械有限公司 | Bilirubin adsorption film with three-dimensional structure and preparation method thereof |
| CN115073645A (en) * | 2022-07-21 | 2022-09-20 | 河北利江生物科技有限公司 | Preparation method and application of resin for purifying serum |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060058413A1 (en) * | 2002-12-30 | 2006-03-16 | Aniela Leistner | Adsorbing material for blood and plasma cleaning method and for albumin purification |
| CN101612543A (en) * | 2008-06-25 | 2009-12-30 | 中国科学院大连化学物理研究所 | Be used for the preparation of the polystyrene-divinylbenzene microspheres of blood purification |
| CN102049242A (en) * | 2011-01-08 | 2011-05-11 | 广州康盛生物科技有限公司 | Anion resin for bilirubin absorption and preparation method thereof |
| CN105367699A (en) * | 2015-12-16 | 2016-03-02 | 宁波争光树脂有限公司 | Arsenic macroreticular adsorption resin and preparation method and application thereof |
| CN105749886A (en) * | 2016-04-08 | 2016-07-13 | 华南理工大学 | Medical polymeric microsphere adsorbent for hemoperfusion apparatus and preparation method of medical polymeric microsphere adsorbent |
| CN106632792A (en) * | 2016-12-01 | 2017-05-10 | 北京大学深圳研究生院 | Preparation method for high-load ion exchange polymer microspheres |
| CN107262057A (en) * | 2016-04-08 | 2017-10-20 | 中国科学院大连化学物理研究所 | A kind of preparation method of bilirubin resin anion (R.A.) adsorbent |
-
2019
- 2019-06-05 CN CN201910487040.6A patent/CN110327893A/en active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060058413A1 (en) * | 2002-12-30 | 2006-03-16 | Aniela Leistner | Adsorbing material for blood and plasma cleaning method and for albumin purification |
| CN101612543A (en) * | 2008-06-25 | 2009-12-30 | 中国科学院大连化学物理研究所 | Be used for the preparation of the polystyrene-divinylbenzene microspheres of blood purification |
| CN102049242A (en) * | 2011-01-08 | 2011-05-11 | 广州康盛生物科技有限公司 | Anion resin for bilirubin absorption and preparation method thereof |
| CN105367699A (en) * | 2015-12-16 | 2016-03-02 | 宁波争光树脂有限公司 | Arsenic macroreticular adsorption resin and preparation method and application thereof |
| CN105749886A (en) * | 2016-04-08 | 2016-07-13 | 华南理工大学 | Medical polymeric microsphere adsorbent for hemoperfusion apparatus and preparation method of medical polymeric microsphere adsorbent |
| CN107262057A (en) * | 2016-04-08 | 2017-10-20 | 中国科学院大连化学物理研究所 | A kind of preparation method of bilirubin resin anion (R.A.) adsorbent |
| CN106632792A (en) * | 2016-12-01 | 2017-05-10 | 北京大学深圳研究生院 | Preparation method for high-load ion exchange polymer microspheres |
Non-Patent Citations (4)
| Title |
|---|
| 张政朴: "《反应性与功能性高分子材料"》", 28 February 2005, 北京化学工业出版社 * |
| 杨天楹，杨成民，田兆嵩: "《临床输血学》", 31 December 1993, 北京医科大学；中国协和医科大学联合出版社 * |
| 肖元丕等: "多微孔胺基树脂的制备及其对胆红素的吸附性能", 《生物工程学报》 * |
| 钱庭宝 等: "《吸附树脂及其应用》", 31 October 1990, 北京化学工业出版社 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110787775A (en) * | 2019-10-31 | 2020-02-14 | 武汉瑞法医疗器械有限公司 | Bilirubin adsorption film with three-dimensional structure and preparation method thereof |
| CN110787775B (en) * | 2019-10-31 | 2022-06-21 | 武汉瑞法医疗器械有限公司 | Bilirubin adsorption film with three-dimensional structure and preparation method thereof |
| CN115073645A (en) * | 2022-07-21 | 2022-09-20 | 河北利江生物科技有限公司 | Preparation method and application of resin for purifying serum |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN105504128B (en) | A kind of absorption resin and its preparation method and application for Phenol-Containing Wastewater Treatment | |
| CN110327894A (en) | A kind of blood purification polymer microsphere of high adsorption capacity and preparation method thereof | |
| KR101227423B1 (en) | Method for producing spherical activated carbon | |
| CN104492402B (en) | The whole blood perfusion preparation method of the adsorbent of absorption low density lipoprotein, LDL | |
| CN105085829B (en) | The preparation method of the macroporous absorbent resin adsorbed for toxic substance | |
| WO2008064525A1 (en) | A super macroporous polymeric microsphere and preparation process thereof | |
| TWI376265B (en) | ||
| CN110327893A (en) | One kind is for bilirubin blood purification polymer microsphere and preparation method thereof | |
| JP6848203B2 (en) | Separator and column | |
| CN102516679B (en) | Magnetic microsphere resin with high specific surface area and preparation method and application thereof | |
| Zeng et al. | Enhanced adsorption of puerarin onto a novel hydrophilic and polar modified post-crosslinked resin from aqueous solution | |
| CN107876031B (en) | Blood purification adsorbent for uremia and preparation method thereof | |
| JP6790834B2 (en) | Separator | |
| CN104174385A (en) | Bilirubin adsorbent for blood perfusion | |
| CN106103477A (en) | Sane antibody purification | |
| CN107973873A (en) | A kind of preparation method of super-hydrophobic high resistance to compression styrene diethylene benzene copoly mer catalyst carrier | |
| CN110117379B (en) | Adsorbing material for removing LDL (low density lipoprotein) in blood perfusion and preparation method thereof | |
| Zeng et al. | Synthesis, characterization and adsorption performance of a novel post-crosslinked adsorbent | |
| EP2959908A1 (en) | Orally administered adsorbent, therapeutic agent for renal disease, and therapeutic agent for liver disease | |
| EP2959906A1 (en) | Orally administered adsorbent, therapeutic agent for renal disease, and therapeutic agent for liver disease | |
| EP0060472B1 (en) | A method for separating t cells from leukocytes | |
| CN108367212A (en) | Use macroporous polymer adsorbent chromatographic isolation organic acid | |
| RU2632432C2 (en) | Orally administrated adsorbent, therapeutic agent for kidney disease and therapeutic agent for liver disease | |
| CN105524223A (en) | Preparation method for porous PS-DVB microsphere used for immobilized enzyme carrier | |
| CN108948255A (en) | A kind of styrene resin and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20191015 |