CN110327377A - Application of the cordyceps powder in caused by ionizing radiation damage prevention and treatment - Google Patents
Application of the cordyceps powder in caused by ionizing radiation damage prevention and treatment Download PDFInfo
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Abstract
The present invention provides application of the cordyceps powder in ionization radiation injury prevention and treatment.Cordyceps powder provided by the invention causes the protective agents of marrow, small intestine, spleen and injury of testis to have that toxic side effect is extremely low, radiation-sensitive organ (marrow, small intestine, spleen, testis) damage control efficiency is obvious, the advantages such as effectively are administered after irradiation damage as ionising radiation.Above-mentioned performance shows that cordyceps powder causes the unique advantage in how radiosensitive organ damage in prevention and treatment ionising radiation, it is therefore intended that develops the ionization radiation injury protective agents of high-efficiency low-toxicity；The multiple organ injury caused by ionising radiation still lacks effectively preventing technological means and Radiation Medicine both at home and abroad and clinical radiation therapy field needs one of emphasis problem researched and solved at present.Therefore, cordyceps powder causes whole body multiple organ injury protective agents to have wide development and application prospect in China's medical domain as ionising radiation.
Description
Technical field
The present invention relates to a kind of applications of cordyceps powder drug, i.e., cause bone in prevention and treatment ionising radiation about cordyceps powder
Application in terms of marrow, small intestine, spleen and injury of testis.
Background technique
As nuclear power source has become the important component of various countries' science and technology and military power, wartime nuclear explosion, core are terrified
Body ionization radiation injury caused by attack, nuclear reactor accident etc. threatens the safety and health of the public.In addition, radiotherapy
One of essential therapeutic arsenals as clinically malignant tumour, while killing tumor cell, inevitably to swollen
Normal tissue organ around tumor causes ionization radiation injury, so as to cause body blood system, gastrointestinal system, siberian crabapple
The damage and sequelae of system, reproductive system etc..
The main mechanism of ionising radiation cause body injury is the fracture that ray leads to DNA by direct and indirect effect, and
And intracorporal hydrone excites under actinism and resolves into free radical, and then attacks large biological molecule and cause each organ
Secondary lesion.The body acute injury that ionising radiation causes is mainly shown as: hemopoietic function of bone marrow seriously damages after radiation, makes
Hemocytoblast and hematopoietic progenitor cells function are impaired, whole blood trace elements；Intestinal villus can occur after irradiation and be crushed, be broken for enteron aisle,
Enteron aisle crypts quantity significantly reduces, and more seriously enteron aisle mechanical barrier declines, intestinal immunological barrier are destroyed, from
And cause serious hemorrhage of gastrointestinal tract, vomiting, diarrhea, bacteremia, septicemia and electrolyte disturbance etc.；White pulp and red pulp in spleen
Between boundary thicken, white pulp area is reduced, and acini lienalis atrophy, immune system gets muddled, and has been further exacerbated by ionising radiation
Damage to body；Sperm mother cell, spermatogonium, sperm will appear oligozoospermia after receiving ionising radiation and (or) lack in testis
Lose, rate of teratosperm increase and androgone denaturation, necrosis and fall off.Therefore, either to nuclear accident or be that clinic is put
The damage study on prevention for penetrating treatment induced Acute radiation sickness is eager and important.
The research and development of radiation protective agents are to mitigate one of most effective means of radiation injury.Amifostine is in the world unique one
It is a by U.S. Food and Drug Administration's approval for clinical radioprotector, however it is its high price, shorter
Half-life period, the toxicity for depending critically upon drug dosage constrain its clinical application.In addition, existing report includes Amifostine
Only administration is effective before irradiation for radiation prevention and treatment substance inside, and the drug for mitigating radiation injury after radiation injury generation rarely has
Report.Therefore, the radiation protective agents for developing high-efficiency low-toxicity are most important for the pain for mitigating radiation injury patient.
Cordyceps militaris also known as northern Chinese caterpillar Fungus, Cordceps militaris etc. belong to Clavicipitaceae, Cordyceps, have adjusting to exempt from taxology
Epidemic disease system inhibits the effects of tumor proliferation, cancer cell specific induction of apoptosis, anti-inflammatory, vasodilator, antifatigue and resisting stress, extensively
It is general to be used for a variety of industries such as pharmacy, health food, beverage, alcoholic.Containing there are many chemical component, extracts in cordyceps powder
With multiple functions, for example, Cordyceps sinensis polysaccharide has antitumor, hypoglycemic, anti-hepatic fibrosis and improves immune function, cordycepin has
Antibacterial, the remarkable effects such as anti-inflammatory, anti-oxidant, adjusting human endocrine and enhancing immune function of human body.But it has no in the prior art
Having cordyceps powder and its extract to radiate acute systemic causes marrow, small intestine, spleen related to injury of testis preventive and therapeutic effect
Report.
Summary of the invention
The object of the present invention is to provide cordyceps powder and its new applications of extract, i.e., anti-in caused by ionizing radiation damage
Application in controlling.To achieve the above object of the invention, the technical solution adopted by the present invention is that: Cordyceps militaris ionising radiation cause marrow,
Application in small intestine, spleen and injury of testis prevention and treatment, the Cordyceps militaris are the pupa worm purchased from Zhong Sheng pharmaceutical Co. Ltd, Jilin Province
Grass volvatus powder capsule.
The male 8 week old mouse of the C57BL/6J ordered from Shanghai Ji Hui experimental animal feeding Co., Ltd are used for by inventor
Zoopery.There is a 12h light and shade period, 20 ~ 25 DEG C and is freely eating in the environment of aqua sterilisa and mouse grain and raise mouse.Mouse with
Machine is divided into the 4 groups: 1st group, irradiation+saline control group；2nd group, irradiation+cordyceps powder low dose group；3rd group, irradiation+
Cordyceps powder middle dose group；4th group, irradiation+cordyceps powder high dose group.Mouse receives the 60Co gamma-rays whole body of 9 Gy
Irradiation, cordyceps powder are suspended with sterile saline, and after irradiation hereafter 0.5 h is administered once a day through gastric infusion, even
Continuous administration 7 days, and mouse survival situation is recorded daily in 30 days after irradiation.As a result, it has been found that giving cordyceps powder after radiation
Mouse survival rate can be significantly improved, it is especially the most significant with high dose group.
Meanwhile inventor also selects irradiation+saline control group and irradiation+cordyceps powder high dose group, is shining
The marrow for taking 2 groups of mouse for 3 days respectively, small intestine, spleen and testis after penetrating carry out HE dye after fixation, wax embedding, slice
Color.The results show that compared with the control group, 3 days according to after, the quantity of karyocyte is obvious in irradiation+saline control group marrow
It reduces, it is hollow in ossis, prompt hemopoietic function of bone marrow by serious destruction.Compared with the control group, pupa worm is given after irradiation
Grass volvatus powder more significant can delay bone marrow injury, and ossis inner cell number is obviously more than control group.The HE slice of small intestine is aobvious
Show, the intestinal villi structural integrity of non-irradiation group, and then occurs villus after irradiating and shorten even fracture, Showed by immune group result
Stem cell population significantly reduces in crypts of small intestine, and injury of small intestine after irradiation can be repaired by giving cordyceps powder, and crypts of small intestine is dry thin
Born of the same parents' number, intestinal villi length etc. have significant reparation.The HE of spleen tissue is sliced the results show that the 3rd day white pulp after irradiation
Boundary thickens between red pulp, and white pulp area is obviously reduced, and the mouse spleen that cordyceps powder is given after irradiating is red white
Marrow boundary is relatively clear and the diminution of white pulp area is unobvious, i.e., Cordyceps militaris, which can effectively mitigate radiation, leads to the damage of spleen.Testis
Ball pathological section the results show that non-irradiation group mouse testis structural integrity, convoluted seminiferous tubules is full, it is clear-cut, it is small after irradiation
Mouse testis inner cell quantity significantly reduces, and convoluted seminiferous tubules internal cavity becomes larger, atrophy, necrosis are more serious, and cordyceps powder energy
Significant repair radiates caused injury of testis.
Therefore, claimed Cordyceps militaris causes in marrow, small intestine, spleen and injury of testis prevention and treatment in ionising radiation
Using.Under to the drug concentration of animal and cell without any apparent side effect, cordyceps are taken after receiving ionising radiation
Powder can mitigate ionization radiation injury, to play the preventive and therapeutic effect of ionization radiation injury.
Compared with the prior art, the present invention has the following advantages: (1) toxic side effect small, and cordyceps powder has been used as one kind
The drug of listing, there is clinical research data abundant, and safety and validity have obtained the confirmation of clinical research；(2)
Significant in efficacy, only administration is effective before irradiation by the existing radiation protective agents overwhelming majority, and radiation event mitigates spoke after occurring
The drug for penetrating damage is rarely reported, and gives cordyceps powder after receiving ionising radiation, can significantly improve mouse survival rate, is mitigated
Marrow, enteron aisle caused by radiation, spleen and injury of testis.Above-mentioned performance all shows Cordyceps militaris and causes body injury in ionising radiation
Excellent effect in prevention and treatment has wide potential applicability in clinical practice.
The above description is only an overview of the technical scheme of the present invention, in order to better understand the technical means of the present invention,
And can be implemented in accordance with the contents of the specification, with presently preferred embodiments of the present invention and cooperate Figure of description specifically below
It is bright.
Detailed description of the invention
Fig. 1 gives various concentration Cordyceps militaris for irradiation group after 9 Gy 60Co gamma-rays full-body exposures of the invention and after irradiating
Bacterium powder mouse survival curve comparison figure.
Fig. 2 gives for first and third, five, seven day irradiation group after 9 Gy 60Co gamma-rays full-body exposures of the invention and after irradiating
Give cordyceps powder (1.25 g) mouse bone marrow cells HE slice comparison diagram.
Fig. 3 A be after 9 Gy 60Co gamma-rays full-body exposures of the invention the mouse small intestine HE slice of third day irradiation group and
Immunohistochemical staining comparison diagram.
Fig. 3 B is to give cordyceps powder (1.25 g) mouse small intestine after 9 Gy 60Co gamma-rays full-body exposures of the invention
HE slice and immunohistochemical staining comparison diagram.
Fig. 4 A gives Cordyceps militaris for third day irradiation group after 9 Gy 60Co gamma-rays full-body exposures of the invention and after irradiating
Bacterium powder (1.25 g) mouse spleen HE is sliced comparison diagram.
Fig. 4 B gives Cordyceps militaris for third day irradiation group after 9 Gy 60Co gamma-rays full-body exposures of the invention and after irradiating
Bacterium powder (1.25 g) mouse spleen HE is sliced white pulp area comparison diagram.
Fig. 5 gives cordyceps for third day irradiation group after 9 Gy 60Co gamma-rays full-body exposures of the invention and after irradiating
Powder (1.25 g) mouse testis HE is sliced comparison diagram.
Specific embodiment
Below with reference to embodiment, the invention will be further described, but protection scope of the present invention is not limited to embodiment.
Embodiment 1: influence of the Cordyceps militaris to mouse survival rate after irradiation
Material and method
1. reagent:
Cordyceps militaris capsules: Zhong Sheng pharmaceutical Co. Ltd, Jilin Province (similarly hereinafter).
Cordyceps powder is suspended with sterile saline, and administration mode is gastric infusion, and every mouse fills 100 microlitres.
2. mouse:
The male 8 week old mouse of C57BL/6J purchased from Shanghai Ji Hui experimental animal feeding Co., Ltd are used for zoopery.Having
It in the 12h light and shade period, 20 ~ 25 DEG C and freely eats in the environment of aqua sterilisa and mouse grain and raises mouse (similarly hereinafter).
3. radiation injury and prevention and treatment experiment
Mouse is randomly divided into the 4 groups: 1st group, irradiation+saline control group；2nd group, irradiation+cordyceps powder low dose group
(0.5 g/kg)；3rd group, irradiation+cordyceps powder middle dose group (1 g/kg)；4th group, irradiation+cordyceps powder high dose
Group (1.25 g/kg).It uses60Co carries out full-body exposure, and exposure dose is 9 Gy, and dosage rate is 1 Gy/min.Stomach-filling after irradiation
The cordyceps powder of physiological saline or various concentration is given, every intragastric administration on mice amount is 100 microlitres.Hereafter successive administration 7 days, and
Record mouse survival situation.Experimental result is shown in Fig. 1.
As shown in Figure 1, there is figure syntexis, loss of appetite etc. after irradiation in irradiation+physiological saline group mouse, and at 10 days
It is interior all dead, and mouse survival rate can be significantly improved by giving cordyceps powder after irradiating, and extend its life span.
Embodiment 2: repair of the Cordyceps militaris to mouse bone marrow cells after irradiation
Material and method
1. reagent:
Cordyceps militaris capsules: Zhong Sheng pharmaceutical Co. Ltd, Jilin Province (similarly hereinafter).General organization fixer is purchased from Wuhan Xavier
Biotechnology Co., Ltd, Yihong are purchased from U.S. Arcos Organics company；Haematoxylin, dehydrated alcohol, dimethylbenzene, embedding
Paraffin, neutral gum are purchased from Chinese Medicine group；Natural gum is purchased from the military rattan Chemical Co., Ltd. of Japan；Paraffin is purchased from Leca
Company.
2. mouse:
The male 8 week old mouse of C57BL/6J purchased from Shanghai Ji Hui experimental animal feeding Co., Ltd are used for zoopery.Having
It in the 12h light and shade period, 20 ~ 25 DEG C and freely eats in the environment of aqua sterilisa and mouse grain and raises mouse (similarly hereinafter).
3. radiation injury and prevention and treatment experiment
Mouse is randomly divided into the 2 groups: 1st group, irradiation+saline control group；2nd group, irradiation+cordyceps powder low dose group
(1.25 g/kg).It uses60Co carries out full-body exposure, and exposure dose is 9 Gy, and dosage rate is 1 Gy/min.Stomach-filling is given after irradiation
Physiological saline or cordyceps powder (1.25 g/kg) are given, every intragastric administration on mice amount is 100 microlitres.Hereafter successive administration, respectively at
1st, 3,5,7 day execution mouse simultaneously takes bone formation to be placed in fixation in tissue fixative solution.Femur through decalcification processing, degreasing dehydration,
After paraffin embedding, maximum longitudal section is cut, slice thickness is 3 μm, is most compared not after hematoxylin eosin staining (HE dyeing) afterwards
The case where with processing group mouse bone marrow cells.Experimental result is shown in Fig. 2.
As shown in Fig. 2, karyocyte of the irradiation+physiological saline group mouse after irradiation in marrow is constantly reduced, and give
The mouse of cordyceps powder, bone marrow injury situation are significantly alleviated, and karyocyte is reduced to minimum in marrow on day 3
It is gradually increased after point, more karyocyte can be seen when the 7th day, the function of this prompt marrow is gradually recovered.
Embodiment 3: repair of the Cordyceps militaris to mouse small intestine after irradiation
Material and method
1. reagent:
Cordyceps militaris capsules: Zhong Sheng pharmaceutical Co. Ltd, Jilin Province (similarly hereinafter).General organization fixer is purchased from Wuhan Xavier
Biotechnology Co., Ltd and HE staining reagent are the same as embodiment 2.Small intestine stem-cell marker protein antibodies OLFM4 is purchased from U.S. CST
Company, Dako REAL EnVision Detection System.Peroxidase/DAB+.Rabbit/Mouse etc..
2. mouse:
The male 8 week old mouse of C57BL/6J purchased from Shanghai Ji Hui experimental animal feeding Co., Ltd are used for zoopery.Having
It in the 12h light and shade period, 20 ~ 25 DEG C and freely eats in the environment of aqua sterilisa and mouse grain and raises mouse (similarly hereinafter).
3. radiation injury and prevention and treatment experiment
Mouse is randomly divided into the 2 groups: 1st group, irradiation+saline control group；2nd group, irradiation+cordyceps powder low dose group
(1.25 g/kg).It uses60Co carries out full-body exposure, and exposure dose is 9 Gy, and dosage rate is 1 Gy/min.Stomach-filling is given after irradiation
Physiological saline or cordyceps powder (1.25 g/kg) are given, every intragastric administration on mice amount is 100 microlitres.Hereafter successive administration 3 days, in
3rd day execution mouse simultaneously takes the small intestine under stomach at 3cm to be placed in fixation in tissue fixative solution.Small intestinl channel degreasing dehydration, paraffin
After embedding, cross section is cut, slice thickness is 3 μm, most afterwards through hematoxylin eosin staining (HE dyeing), immunohistochemical staining
(OLFM4) the case where comparing different disposal group mouse small intestine afterwards.Experimental result is shown in Fig. 3 A and Fig. 3 B.
As shown in Figure 3A and Figure 3B, compared with the control group, intestinal villi obviously contracts irradiation+physiological saline group mouse after irradiation
Short, villus cell is dead, and intestinal crypt stem cells quantity is sharply reduced, and gives the small intestine damage that cordyceps powder can alleviate mouse
Wound maintains the length of intestinal crypt stem cells number and villus.
Embodiment 4: repair of the Cordyceps militaris to mouse spleen after irradiation
Material and method
1. reagent:
Cordyceps militaris capsules: Zhong Sheng pharmaceutical Co. Ltd, Jilin Province (similarly hereinafter).General organization fixer is purchased from Wuhan Xavier
Biotechnology Co., Ltd and HE staining reagent are the same as embodiment 2.
2. mouse:
The male 8 week old mouse of C57BL/6J purchased from Shanghai Ji Hui experimental animal feeding Co., Ltd are used for zoopery.Having
It in the 12h light and shade period, 20 ~ 25 DEG C and freely eats in the environment of aqua sterilisa and mouse grain and raises mouse (similarly hereinafter).
3. radiation injury and prevention and treatment experiment
Mouse is randomly divided into the 2 groups: 1st group, irradiation+saline control group；2nd group, irradiation+cordyceps powder low dose group
(1.25 g/kg).It uses60Co carries out full-body exposure, and exposure dose is 9 Gy, and dosage rate is 1 Gy/min.Stomach-filling is given after irradiation
Physiological saline or cordyceps powder (1.25 g/kg) are given, every intragastric administration on mice amount is 100 microlitres.Hereafter successive administration 3 days, in
3rd day execution mouse simultaneously takes spleen tissue to be placed in fixation in tissue fixative solution.Spleen is cut most after degreasing dehydration, paraffin embedding
Big longitudal section, slice thickness are 3 μm, most compare different disposal group mouse spleen after hematoxylin eosin staining (HE dyeing) afterwards
The case where.Experimental result is shown in Fig. 4 A and Fig. 4 B.
As shown in Figure 4 A, compared with the control group, irradiation+physiological saline group mouse spleen white pulp after irradiation and red pulp are handed over
Boundary is fuzzy, and the area of white pulp is obviously reduced, and prompts immune function depression, and after giving cordyceps powder, spleen white pulp and red pulp
Boundary it is still clear.As shown in Figure 4 B, after giving cordyceps powder, the trend that spleen white pulp area reduces is suppressed significantly.
Embodiment 5: repair of the Cordyceps militaris to mouse testis after irradiation
Material and method
1. reagent:
Cordyceps militaris capsules: Zhong Sheng pharmaceutical Co. Ltd, Jilin Province (similarly hereinafter).General organization fixer is purchased from Wuhan Xavier
Biotechnology Co., Ltd and HE staining reagent are the same as embodiment 2.
2. mouse:
The male 8 week old mouse of C57BL/6J purchased from Shanghai Ji Hui experimental animal feeding Co., Ltd are used for zoopery.Having
It in the 12h light and shade period, 20 ~ 25 DEG C and freely eats in the environment of aqua sterilisa and mouse grain and raises mouse (similarly hereinafter).
3. radiation injury and prevention and treatment experiment
Mouse is randomly divided into the 2 groups: 1st group, irradiation+saline control group；2nd group, irradiation+cordyceps powder low dose group
(1.25 g/kg).It uses60Co carries out full-body exposure, and exposure dose is 9 Gy, and dosage rate is 1 Gy/min.Stomach-filling is given after irradiation
Physiological saline or cordyceps powder (1.25 g/kg) are given, every intragastric administration on mice amount is 100 microlitres.Hereafter successive administration 3 days, in
3rd day execution mouse simultaneously takes testis tissue to be placed in fixation in tissue fixative solution.Testis is cut most after degreasing dehydration, paraffin embedding
Big longitudal section, slice thickness are 3 μm, most compare different disposal group mouse testis after hematoxylin eosin staining (HE dyeing) afterwards
The case where.Experimental result is shown in Fig. 5.
As shown in figure 5, compared with the control group, the testis inner cell quantity of irradiation+physiological saline group mouse after irradiation is reduced, essence
Distal convoluted tubule internal cavity becomes larger, and with atrophy, necrosis, and after mouse gives cordyceps powder, testicular cell quantity is relatively more,
Convoluted seminiferous tubules structure is relatively complete, and overall impairment degree is substantially reduced.
Statistical procedures: all experiments of above-described embodiment be repeated 3 times it is above, as a result using Mean ± SD indicate.It adopts
T inspection is carried out to related data with 5 statistical software of GraphPad Prism, survival rate uses Log-rank (Mantel-Cox)
It examines, is to have significant difference with P < 0.05.
Claims (6)
1. cordyceps powder causes the application in marrow, small intestine, spleen and injury of testis prevention and treatment in ionising radiation.
2. a kind of ionising radiation causes marrow, small intestine, spleen and injury of testis protective agents, active constituent is cordyceps powder.
3. ionising radiation according to claim 2 causes marrow, small intestine, spleen and injury of testis protective agents, feature to exist
In it further includes the extract of cordyceps powder that the ionising radiation, which causes marrow, small intestine, spleen and injury of testis protective agents,.
4. cordyceps powder according to claim 1 causes in marrow, small intestine, spleen and injury of testis prevention and treatment in ionising radiation
Application, which is characterized in that the cordyceps powder is via oral administration.
5. cordyceps powder according to claim 1 causes in marrow, small intestine, spleen and injury of testis prevention and treatment in ionising radiation
Application, which is characterized in that ionising radiation mode be gamma-rays irradiation.
6. cordyceps powder according to claim 1 causes in marrow, small intestine, spleen and injury of testis prevention and treatment in ionising radiation
Application, which is characterized in that the animal dosage of the cordyceps powder be 0.5 g/kg, 1 g/kg, 1.25 g/kg,
And 0.5 hour after ionising radiation is administered.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113908180A (en) * | 2021-11-13 | 2022-01-11 | 广东暨创硒源纳米研究院有限公司 | Application of nano-selenium cordyceps militaris aqueous extract in reducing radiotherapy injury and protective agent thereof |
| WO2023082217A1 (en) * | 2021-11-13 | 2023-05-19 | 广东暨创硒源纳米研究院有限公司 | Use of nano-selenium cordyceps militaris aqueous extract in reducing radiotherapy injury and protective agent |
| CN117025407A (en) * | 2023-06-28 | 2023-11-10 | 中国人民解放军海军特色医学中心 | Curvularia fungus and application thereof in preparation of anti-radiation injury drugs |
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2019
- 2019-08-14 CN CN201910747383.1A patent/CN110327377A/en not_active Withdrawn
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113908180A (en) * | 2021-11-13 | 2022-01-11 | 广东暨创硒源纳米研究院有限公司 | Application of nano-selenium cordyceps militaris aqueous extract in reducing radiotherapy injury and protective agent thereof |
| WO2023082217A1 (en) * | 2021-11-13 | 2023-05-19 | 广东暨创硒源纳米研究院有限公司 | Use of nano-selenium cordyceps militaris aqueous extract in reducing radiotherapy injury and protective agent |
| CN117025407A (en) * | 2023-06-28 | 2023-11-10 | 中国人民解放军海军特色医学中心 | Curvularia fungus and application thereof in preparation of anti-radiation injury drugs |
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Application publication date: 20191015 |