CN110327019A - Cerenkov fluoroscopic imaging systems and its image processing method are organized in art - Google Patents
Cerenkov fluoroscopic imaging systems and its image processing method are organized in art Download PDFInfo
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- 238000003384 imaging method Methods 0.000 title claims abstract description 48
- 238000003672 processing method Methods 0.000 title claims abstract description 19
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0071—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by measuring fluorescence emission
Abstract
The invention belongs to optical molecular imaging fields, and in particular to Cerenkov fluoroscopic imaging systems and its image processing method are organized in a kind of art, it is intended to solve the problems, such as that frozen pathologic section materials area is small in art, analysis time is long.Present system includes: light source module, is organized for emitting in white light art；Information acquisition module, for acquiring the colored White-light image organized in art, gray scale White-light image, Cerenkov fluorescent image；Central control module, control light source module shines, information acquisition module acquires image and receives the image information of light source module status information, information acquisition module acquisition, passes through built-in image processing algorithm and generates organization chart picture in art.Imaging system of the present invention, imaging have spontaneous emissions, and signal-to-background ratio is high, and imaging process high specificity, high sensitivity, shallow layer resolution are high, image taking speed is fast, can quickly, efficiently realize in art and incisxal edge is organized to examine.
Description
Technical field
The invention belongs to optical molecular imaging fields, and in particular to Cerenkov fluoroscopic imaging systems are organized in a kind of art
And its image processing method.
Background technique
According to Cancer in China statistical data, the incidence and mortality ranking of colorectal cancer ranks forefront, and seriously threatens national health
It is horizontal.In China, the ratio of patients with lower rectal cancer reaches 65% or more, and conventional treatment means are based on excision of performing the operation.
For the shorter survival and quality of life for improving patient, need in the course of surgery, to detect the boundary of resection organization, with true
Protect tumor tissues are retained patient as much as possible normal rectal tissue while complete resection.Present clinical practice in frequently with
The mode of frozen section in art, the tumor tissues lower to excision carry out border detection, if border detection result is positive, then tumour
Not excision completely, need to further cut off perienchyma.
However, in art frozen section detection tumor resection boundary method there are many limitations: (1) in art freeze materials face
Product is small, samples the judgement based on doctor and clinical experience, influences the accuracy of tumor boundaries detection；(2) low rectal carcinectomy
The range on boundary is smaller, and tumor tissues may be injured in sampling process, causes implantation metastasis hidden danger；(3) frozen section in art
Need 20 minutes or more, during which doctor can not carry out subsequent procedures operation, thus increase the anesthetic risks of patient.For this reason, it may be necessary to
Detection method in the novel art of one kind is designed, auxiliary doctor quickly and accurately detects the boundary of tumor resection, improves operation plan
The reasonability of selection, the risk for reducing operation.
Meanwhile with the raising required oncotherapy accuracy, treated by the tumor operation of representative of Low Rectal
In, it while tumor resection, needs to retain normal tissue as much as possible, to improve the quality of life after patient's treatment.But
The irregular feature of tumour growth, by small ranges spot sampling methods such as frozen sections in art, it is difficult to quickly and accurately recognize
The form of tumor tissues, to limit the promotion of tumorectomy accuracy.
Generally speaking, frozen pathologic section is drawn materials in traditional art, and area is small, analysis time is long, is unable to satisfy in art synchronous
The requirement of detection.
Summary of the invention
In order to solve the above problem in the prior art, i.e., in art, frozen pathologic section is drawn materials, and area is small, analysis time is long
The problem of, the present invention provides Cerenkov fluoroscopic imaging systems are organized in a kind of art, which includes light source die
Block, information acquisition module, central control module；
The light source module, including white-light emitting device, for emitting white light；The white light, is organized for irradiating in art；
The information acquisition module, for acquiring the colored White-light image organized in the art, gray scale White-light image, Qi Lun
Section's husband's fluorescent image；
The central control module is configured to connect by the first communication link with the light source module, sends light source control
Signal processed, and receive light source state signal；It is connect by the second communication link with the information acquisition module, sends information and adopt
Set control signal, and the colored White-light image of the reception information acquisition module acquisition, gray scale White-light image, Cerenkov are glimmering
Light image simultaneously generates organization chart picture in art by Built-in Image Processing Algorithm.
In some preferred embodiments, the information acquisition module includes white light camera, Cerenkov fluorescence camera, becomes
Zoom lens；
The white light camera, for acquiring the colored White-light image organized in art；
The Cerenkov fluorescence camera, for acquiring the gray scale White-light image organized in art, Cerenkov fluorescent image；
The zoom lens is configured to connect by adapter ring with the white light camera, Cerenkov fluorescence camera, be used for
Adjust the white light camera, Cerenkov fluorescence camera imaging region size.
In some preferred embodiments, the central control module includes signal control module, data read module, figure
As processing module；
The signal control module, be configured to generate the light source module, the information acquisition module control signal simultaneously
It is sent to corresponding module, and receives the light source state signal that the light source module is sent；
The data read module is configured to the colored white light figure organized in the art for receiving the information acquisition module acquisition
Picture, gray scale White-light image, Cerenkov fluorescent image are simultaneously sent to described image processing module；
Described image processing module is configured to receive the colored white light figure organized in the art that the data read module is sent
Picture, gray scale White-light image, Cerenkov fluorescent image, and organization chart picture in art is generated by built-in image processing algorithm.
In some preferred embodiments, the central control module further includes image display；
Described image display module is configured to connect by communication link with the data read module, receives and show
Colored White-light image, the gray scale White-light image, Cerenkov fluorescent image organized in art；Pass through communication link and the signal control
The connection of molding block, receives and shows the light source module status information；It is connect by communication link with described image processing module,
Receive and show organization chart picture in the Cerenkov puppet color superimposed image in image processing process and the art ultimately generated.
It further includes power module that Cerenkov fluoroscopic imaging systems are organized in some preferred embodiments, in the art；
The power module is configured to provide power supply by power circuit for each module.
Another aspect of the present invention proposes and organizes image processing method in Cerenkov fluoroscopic imaging systems in a kind of art
Method, based on tissue Cerenkov fluoroscopic imaging systems, image processing method in above-mentioned art are as follows:
Step S10 obtains colored White-light image, the gray scale White-light image, Cerenkov fluorescent image organized in art；
Step S20 is calculated by method for registering images the gray scale White-light image being mapped to the colored White-light image
On transformation matrix；
Step S30 is marked pixel by clustering algorithm according to pixel value size in the Cerenkov fluorescent image
For fluorescence signal region, background area；
The pixel in the fluorescence signal region is mapped as pseudo-colours according to pixel value size, with the back by step S40
Scene area constitutes pseudo color image；
The pseudo color image is added to the colored white light based on the transformation matrix that step S20 is obtained by step S50
On image, organization chart picture in art is obtained.
In some preferred embodiments, in step S30 " according to pixel value size in the Cerenkov fluorescent image,
Pixel is labeled as fluorescence signal region, background area by clustering algorithm " it is additionally provided with Cerenkov fluorescent image before
The step of denoising, method are as follows:
The Cerenkov fluorescent image is denoised by median filtering, gaussian filtering method, the Qi Lun after being denoised
Section's husband's fluorescent image.
In some preferred embodiments, " based on the transformation matrix that step S20 is obtained, by the pseudo-colours in step S50
On image superposition to the colored White-light image, organization chart picture in art is obtained " it is additionally provided with colored White-light image prospect, back before
The step of scape contrast enhances, method are as follows:
The colored White-light image is handled by histogram equalization method, it is enhanced to obtain prospect, background contrasts
Colored White-light image.
The third aspect of the present invention proposes a kind of storage device, wherein be stored with a plurality of program, described program be suitable for by
Processor is loaded and is executed to realize above-mentioned image processing method.
The fifth aspect of the present invention proposes a kind of processing unit, including processor, storage device；The processor is fitted
In each program of execution；The storage device is suitable for storing a plurality of program；Described program be suitable for loaded by processor and executed with
Realize above-mentioned image processing method.
Beneficial effects of the present invention:
Cerenkov fluoroscopic imaging systems are organized in art of the present invention, Cerenkov fluorescence imaging has spontaneous emissions, letter back
Than high, imaging process high specificity, high sensitivity, shallow layer resolution are high, image taking speed is fast, and it is glimmering to avoid body tissue Cerenkov
The problems such as light imaging is existing opacus, exposure is too long, can quickly, efficiently realize in art and incisxal edge is organized to examine.
Detailed description of the invention
By reading a detailed description of non-restrictive embodiments in the light of the attached drawings below, the application's is other
Feature, objects and advantages will become more apparent upon:
Fig. 1 is the structural schematic diagram that Cerenkov fluoroscopic imaging systems are organized in art of the present invention；
Fig. 2 is the light source module distribution map that a kind of embodiment of Cerenkov fluoroscopic imaging systems is organized in art of the present invention；
Fig. 3 is to organize a kind of information acquisition module structure of embodiment of Cerenkov fluoroscopic imaging systems to show in art of the present invention
It is intended to；
Fig. 4 is the application method process signal that a kind of embodiment of Cerenkov fluoroscopic imaging systems is organized in art of the present invention
Figure；
Fig. 5 is the flow diagram that image processing method in Cerenkov fluoroscopic imaging systems is organized in art of the present invention.
Specific embodiment
The application is described in further detail with reference to the accompanying drawings and examples.It is understood that this place is retouched
The specific embodiment stated is only used for explaining related invention, rather than the restriction to the invention.It also should be noted that in order to just
Part relevant to related invention is illustrated only in description, attached drawing.
It should be noted that in the absence of conflict, the features in the embodiments and the embodiments of the present application can phase
Mutually combination.The application is described in detail below with reference to the accompanying drawings and in conjunction with the embodiments.
In a kind of art of the invention organize Cerenkov fluoroscopic imaging systems, the fluoroscopic imaging systems include light source module,
Information acquisition module, central control module；
The light source module, including white-light emitting device, for emitting white light；The white light, is organized for irradiating in art；
The information acquisition module, for acquiring the colored White-light image organized in the art, gray scale White-light image, Qi Lun
Section's husband's fluorescent image；
The central control module is configured to connect by the first communication link with the light source module, sends light source control
Signal processed, and receive light source state signal；It is connect by the second communication link with the information acquisition module, sends information and adopt
Set control signal, and the colored White-light image of the reception information acquisition module acquisition, gray scale White-light image, Cerenkov are glimmering
Light image simultaneously generates organization chart picture in art by Built-in Image Processing Algorithm.
In order to more clearly organize Cerenkov fluoroscopic imaging systems to be illustrated in art of the present invention, below with reference to Fig. 1
Module each in present system embodiment is unfolded to be described in detail.
Cerenkov fluoroscopic imaging systems, including light source module, information collection are organized in the art of an embodiment of the present invention
Module, central control module, each module are described in detail as follows:
Light source module, including white-light emitting device, for emitting white light；The white light, is organized for irradiating in art.
As shown in Fig. 2, for tissue a kind of light source module of embodiment of Cerenkov fluoroscopic imaging systems point in art of the present invention
Butut includes two light supply apparatus in the embodiment of the present invention such as Fig. 2 left figure, the upper left corner and the upper right corner organized in art respectively,
It is in 45° angle, the surface that camera, camera lens are organized in art, close to imaging mouth with tissue in illuminated art；Fig. 2 right figure is this
The light-source structure of light supply apparatus in inventive embodiments is a ring-type, is uniformly distributed 8 LED light thereon.
The information acquisition module, for acquiring the colored White-light image organized in the art, gray scale White-light image, Qi Lun
Section's husband's fluorescent image.
As shown in figure 3, for the information collection mould for organizing a kind of embodiment of Cerenkov fluoroscopic imaging systems in art of the present invention
Block structure schematic diagram, including white light camera and Cerenkov fluorescence camera are connected by adapter ring with corresponding zoom lens respectively
It connects.
Information acquisition module includes white light camera, Cerenkov fluorescence camera, zoom lens.
White light camera, for acquiring the colored White-light image organized in art.
In the embodiment of the present invention, white light camera is high speed, high sensitivity, high-resolution pco.edge sCMOS camera.
Cerenkov fluorescence camera, for acquiring the gray scale White-light image organized in art, Cerenkov fluorescent image.
In the embodiment of the present invention, Cerenkov fluorescence camera is 888 EMCCD camera of Andor iXon, uses water cooling
Circulation temperature lowering equipment, operating temperature are subzero 95 degrees Celsius.
Zoom lens is configured to connect by adapter ring with the white light camera, Cerenkov fluorescence camera, for adjusting
The white light camera, Cerenkov fluorescence camera imaging region size.
In the embodiment of the present invention, zoom lens is 0.95/17 camera lens of Schneider Kreuznach Xenon.
White light camera can be connected by data line and USB3.0 interface with central control module；Cerenkov fluorescence
The 2m Multi I/O timing cable and central control module that camera can be carried by data line and Andor camera
Connection.
The central control module is configured to connect by the first communication link with the light source module, sends light source control
Signal processed, and receive light source state signal；It is connect by the second communication link with the information acquisition module, sends information and adopt
Set control signal, and the colored White-light image of the reception information acquisition module acquisition, gray scale White-light image, Cerenkov are glimmering
Light image simultaneously generates organization chart picture in art by Built-in Image Processing Algorithm.
Central control module includes signal control module, data read module, image processing module.
Signal control module, be configured to generate the light source module, the information acquisition module control signal and send
To corresponding module, and the light source state signal that the reception light source module is sent.
Data read module, be configured to receive the colored White-light image organized in the art of the information acquisition module acquisition,
Gray scale White-light image, Cerenkov fluorescent image are simultaneously sent to described image processing module.
Image processing module, be configured to receive the colored White-light image organized in the art that the data read module is sent,
Gray scale White-light image, Cerenkov fluorescent image, and organization chart picture in art is generated by built-in image processing algorithm.
Central control module further includes image display:
Image display is configured to connect by communication link with the data read module, receives and show in art
The colored White-light image of tissue, gray scale White-light image, Cerenkov fluorescent image；Mould is controlled by communication link and the signal
Block connection, receives and shows the light source module status information；It is connect, is received with described image processing module by communication link
And show organization chart picture in the Cerenkov puppet color superimposed image in image processing process and the art ultimately generated.
It further includes power module that Cerenkov fluoroscopic imaging systems are organized in art:
Power module is configured to provide power supply by power circuit for each module.
As shown in figure 4, for the application method stream for organizing a kind of embodiment of Cerenkov fluoroscopic imaging systems in art of the present invention
Journey schematic diagram organizes Cerenkov fluoroscopic imaging systems operational process in an embodiment of the invention in art are as follows:
The first step controls white-light emitting device in light source module and shines, and the signal control module of central control module is to white
Light camera output signal acquires colored White-light image；
Second step, the signal control module of central control module acquire gray scale White-light image to fluorescence camera output signal；
Third step controls white-light emitting device in light source module and stops shining, the signal control module of central control module
To fluorescence camera output signal, fluorescent image is acquired；
4th step, using organization chart picture in the image processing algorithm generation art built in central control module and in display module
Middle display.
Image processing method in Cerenkov fluoroscopic imaging systems is organized in the art of second embodiment of the invention, based on above-mentioned
Art in organize Cerenkov fluoroscopic imaging systems, image processing method are as follows:
Step S10 obtains colored White-light image, the gray scale White-light image, Cerenkov fluorescent image organized in art.
Step S20 is calculated by method for registering images the gray scale White-light image being mapped to the colored White-light image
On transformation matrix.
Step S30 is marked pixel by clustering algorithm according to pixel value size in the Cerenkov fluorescent image
For fluorescence signal region, background area.
" according to pixel value size in the Cerenkov fluorescent image, pixel is labeled as by fluorescence by clustering algorithm
The step of denoising of Cerenkov fluorescent image is additionally provided with before signal area, background area ", method are as follows:
The Cerenkov fluorescent image is denoised by median filtering, gaussian filtering method, the Qi Lun after being denoised
Section's husband's fluorescent image.
The pixel in the fluorescence signal region is mapped as pseudo-colours according to pixel value size, with the back by step S40
Scene area constitutes pseudo color image.
The pseudo color image is added to the colored white light based on the transformation matrix that step S20 is obtained by step S50
On image, organization chart picture in art is obtained.
" based on the transformation matrix that step S20 is obtained, the pseudo color image is added in the colored White-light image,
The step of colored White-light image prospect, background contrasts enhancing are additionally provided with before organization chart picture in acquisition art ", method are as follows:
The colored White-light image is handled by histogram equalization method, it is enhanced to obtain prospect, background contrasts
Colored White-light image.
As shown in figure 5, to organize the process of image processing method in Cerenkov fluoroscopic imaging systems to show in art of the present invention
It is intended to, to the colored White-light image, gray scale White-light image, Cerenkov fluorescent image organized in the art of acquisition, is matched by image
Quasi- method, which is calculated, is mapped to the transformation matrix in colored White-light image for gray scale White-light image, while according to Cerenkov fluorogram
Pixel is labeled as fluorescence signal region, background area by clustering algorithm by the pixel value size as in, and by fluorescence signal area
The pixel in domain is mapped as pseudo-colours according to pixel value size, constitutes pseudo color image with background area, finally based on transformation square
Battle array, pseudo color image is added in colored White-light image, obtains organization chart picture in art.
A kind of storage device of third embodiment of the invention, wherein being stored with a plurality of program, described program is suitable for by handling
Device is loaded and is executed to realize above-mentioned image processing method.
A kind of processing unit of fourth embodiment of the invention, including processor, storage device；Processor is adapted for carrying out each
Program；Storage device is suitable for storing a plurality of program；Described program is suitable for being loaded by processor and being executed to realize above-mentioned figure
As processing method.
Person of ordinary skill in the field can be understood that, for convenience and simplicity of description, foregoing description
The specific work process and related explanation of storage device, processing unit, can refer to corresponding processes in the foregoing method embodiment,
Details are not described herein.
Those skilled in the art should be able to recognize that, mould described in conjunction with the examples disclosed in the embodiments of the present disclosure
Block, method and step, can be realized with electronic hardware, computer software, or a combination of the two, software module, method and step pair
The program answered can be placed in random access memory (RAM), memory, read-only memory (ROM), electrically programmable ROM, electric erasable and can compile
Any other form of storage well known in journey ROM, register, hard disk, moveable magnetic disc, CD-ROM or technical field is situated between
In matter.In order to clearly demonstrate the interchangeability of electronic hardware and software, in the above description according to function generally
Describe each exemplary composition and step.These functions are executed actually with electronic hardware or software mode, depend on technology
The specific application and design constraint of scheme.Those skilled in the art can carry out using distinct methods each specific application
Realize described function, but such implementation should not be considered as beyond the scope of the present invention.
Term " first ", " second " etc. are to be used to distinguish similar objects, rather than be used to describe or indicate specific suitable
Sequence or precedence.
Term " includes " or any other like term are intended to cover non-exclusive inclusion, so that including a system
Process, method, article or equipment/device of column element not only includes those elements, but also including being not explicitly listed
Other elements, or further include the intrinsic element of these process, method, article or equipment/devices.
So far, it has been combined preferred embodiment shown in the drawings and describes technical solution of the present invention, still, this field
Technical staff is it is easily understood that protection scope of the present invention is expressly not limited to these specific embodiments.Without departing from this
Under the premise of the principle of invention, those skilled in the art can make equivalent change or replacement to the relevant technologies feature, these
Technical solution after change or replacement will fall within the scope of protection of the present invention.
Claims (10)
1. in a kind of art organize Cerenkov fluoroscopic imaging systems, which is characterized in that the fluoroscopic imaging systems include light source module,
Information acquisition module, central control module；
The light source module, including white-light emitting device, for emitting white light；The white light, is organized for irradiating in art；
The information acquisition module, for acquiring the colored White-light image organized in the art, gray scale White-light image, Cerenkov
Fluorescent image；
The central control module is configured to connect by the first communication link with the light source module, sends light source control letter
Number, and receive light source state signal；It is connect by the second communication link with the information acquisition module, sends information collection control
Signal processed, and receive colored White-light image, the gray scale White-light image, Cerenkov fluorogram of the information acquisition module acquisition
As and by Built-in Image Processing Algorithm generates organization chart picture in art.
2. organizing Cerenkov fluoroscopic imaging systems in art according to claim 1, which is characterized in that the information collection
Module includes white light camera, Cerenkov fluorescence camera, zoom lens；
The white light camera, for acquiring the colored White-light image organized in art；
The Cerenkov fluorescence camera, for acquiring the gray scale White-light image organized in art, Cerenkov fluorescent image；
The zoom lens is configured to connect by adapter ring with the white light camera, Cerenkov fluorescence camera, for adjusting
The white light camera, Cerenkov fluorescence camera imaging region size.
3. organizing Cerenkov fluoroscopic imaging systems in art according to claim 1, which is characterized in that the center control
Module includes signal control module, data read module, image processing module；
The signal control module, be configured to generate the light source module, the information acquisition module control signal and send
To corresponding module, and the light source state signal that the reception light source module is sent；
The data read module, be configured to receive the colored White-light image organized in the art of the information acquisition module acquisition,
Gray scale White-light image, Cerenkov fluorescent image are simultaneously sent to described image processing module；
Described image processing module, be configured to receive the colored White-light image organized in the art that the data read module is sent,
Gray scale White-light image, Cerenkov fluorescent image, and organization chart picture in art is generated by built-in image processing algorithm.
4. organizing Cerenkov fluoroscopic imaging systems in art according to claim 3, which is characterized in that the center control
Module further includes image display；
Described image display module is configured to connect by communication link with the data read module, receives and show in art
The colored White-light image of tissue, gray scale White-light image, Cerenkov fluorescent image；Mould is controlled by communication link and the signal
Block connection, receives and shows the light source module status information；It is connect, is received with described image processing module by communication link
And show organization chart picture in the Cerenkov puppet color superimposed image in image processing process and the art ultimately generated.
5. organizing Cerenkov fluoroscopic imaging systems in art according to claim 1-4, which is characterized in that described
It further includes power module that Cerenkov fluoroscopic imaging systems are organized in art；
The power module is configured to provide power supply by power circuit for each module.
6. organizing image processing method in Cerenkov fluoroscopic imaging systems in a kind of art, which is characterized in that be based on claim
Cerenkov fluoroscopic imaging systems, image procossing method are organized in art described in 1-5 are as follows:
Step S10 obtains colored White-light image, the gray scale White-light image, Cerenkov fluorescent image organized in art；
Step S20 is calculated by method for registering images and the gray scale White-light image is mapped in the colored White-light image
Transformation matrix；
Step S30, according to pixel value size in the Cerenkov fluorescent image, by clustering algorithm by pixel labeled as glimmering
Optical signal region, background area；
The pixel in the fluorescence signal region is mapped as pseudo-colours according to pixel value size, with the background area by step S40
Domain constitutes pseudo color image；
The pseudo color image is added to the colored White-light image based on the transformation matrix that step S20 is obtained by step S50
On, obtain organization chart picture in art.
7. organizing image processing method in Cerenkov fluoroscopic imaging systems in art according to claim 6, feature exists
In " according to pixel value size in the Cerenkov fluorescent image, pixel being labeled as by clustering algorithm in step S30
The step of denoising of Cerenkov fluorescent image is additionally provided with before fluorescence signal region, background area ", method are as follows:
The Cerenkov fluorescent image is denoised by median filtering, gaussian filtering method, the Cerenkov after being denoised
Fluorescent image.
8. organizing image processing method in Cerenkov fluoroscopic imaging systems in art according to claim 6, feature exists
In " based on the transformation matrix that step S20 is obtained, the pseudo color image being added to the colored White-light image in step S50
On, obtain art in organization chart picture " before be additionally provided with colored White-light image prospect, background contrasts enhancing the step of, method
Are as follows:
The colored White-light image is handled by histogram equalization method, obtains prospect, the enhanced colour of background contrasts
White-light image.
9. a kind of storage device, wherein being stored with a plurality of program, which is characterized in that described program is suitable for being loaded and being held by processor
Row is to realize image processing method described in claim 6-8.
10. a kind of processing unit, including
Processor is adapted for carrying out each program；And
Storage device is suitable for storing a plurality of program；
It is characterized in that, described program is suitable for being loaded by processor and being executed to realize:
Image processing method described in claim 6-8.
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