CN110320257A - A kind of blood glucose sensor and preparation method thereof based on metallic zinc organic transistor - Google Patents
A kind of blood glucose sensor and preparation method thereof based on metallic zinc organic transistor Download PDFInfo
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Abstract
A kind of blood glucose sensor and preparation method thereof based on metallic zinc organic transistor, the sensor include substrate layer, the electrode layer on substrate layer, the insulating layer on electrode layer, the reagent layer on insulating layer, the display layer on reagent layer；The material of the reagent layer is Zn-MOFs Organometallic framework material.Sensor reagent layer choosing Zn metal organic framework crystal, since Zn-MOFs framework material is porous nano, and the structure with high-sequential, pass through the adjustable internal environment of chemical synthesis, make it in conjunction with determinand height, the rapid osmotic and raising enzyme immobilizatio ratio and activity to tested sample keep having larger benefit, have blood sampling volume few, high sensitivity, the high advantage of precision.
Description
Technical field
The invention belongs to nano biological sensor technical field, in particular to a kind of blood based on metallic zinc organic transistor
Sugar detection sensor and preparation method thereof.
Background technique
In recent years, the field of biosensors research in China was very active, and research talent troop goes from strength to strength, and ground on basis
A large amount of achievement is had accumulated in studying carefully, and is had laid a good foundation in terms of developing bio-sensing instrument for China.Industry development is rapid,
Industry size rapidly expands, and the income from sales of China's sensor industry shows the trend increased year by year, science and technology field,
Increasingly important role is played in industrial and agricultural production and daily life.In the production of system for detecting blood sugar, blood glucose is passed
The research and development of sensor are crucial.In order to reach more accurate quantitative measurment purpose, it is mesh that the mode of electrochemistry, which prepares blood glucose sensor,
Preceding research boom has good industrialization prospect.
Blood glucose sensor has many difficult points in development process, such as: highly sensitive, consistency, simple technique, low production
Cost, convenient to use etc. etc. need to reach certain standard.The technology of preparing of blood glucose sensor is mostly by famous foreign at present
Domestic and international market is captured in business monopoly.As country was in the policy support in this field in recent years, also increasing is ground in succession for domestic enterprise
Hair investment, obtains the blood glucose sensor of proprietary technology.Traditional blood glucose sensor is mostly by adulterating or answering in carbon paste electrode
Conductive silver paste is printed to reduce basic resistance and improve the redox ability of electrode, to a certain extent, does so and solves one
Fixed thorny problem, but the disadvantage is that complex process, cost of manufacture is high, poor sensitivity when use, and blood sampling volume is more.Therefore, tool is developed
The blood glucose sensor for having market potential is always the direction that we make great efforts.
Summary of the invention
The first purpose of this invention is to provide a kind of blood glucose sensor based on metallic zinc organic transistor, to solve
Existing sensor blood sampling volume is big, the technical problem of poor sensitivity.
To achieve the goals above, The technical solution adopted by the invention is as follows:
A kind of blood glucose sensor based on metallic zinc organic transistor, electrode layer including substrate layer, on substrate layer,
Insulating layer on electrode layer, the reagent layer on insulating layer, the display layer on reagent layer；The improvement done is,
The material of the reagent layer is Zn-MOFs Organometallic framework material；
The preparation process of the Zn-MOFs Organometallic framework material the following steps are included:
Terephthalic acid (TPA) is weighed in small beaker, sodium hydroxide solution is slowly added dropwise thereto, mixing, which is sufficiently stirred, makes it
Dissolution, then with hydrochloric acid solution tune pH to neutrality, precursor solution is made；
Zn (Ac) is weighed later2·2H2In a round bottom flask, deionized water is added in O thereto, and ultrasound makes it dissolve, then
CTAB is added in wherein, is stirred at room temperature, dissolution is mixed well, mixed solution is made；
The precursor solution of above-mentioned preparation is slowly added drop-wise in mixed solution, certain time is stirred, it will is generated a large amount of
Solution is being centrifuged by white precipitate after reaction, respectively with ethyl alcohol, distillation water washing, is then dried in a vacuum drying oven,
Zn-MOFs Organometallic framework material can be obtained；
Or, weighing sodium acetate, PVP in a round bottom flask, DMF, dehydrated alcohol, deionized water are measured in above-mentioned round-bottomed flask
In；The round-bottomed flask for filling mixed solvent is placed in ultrasonic cleaning machine and is ultrasonically treated, is mixed well, transfers to and has been warmed up
Into the oil bath of reaction temperature, keeps temperature and stir；
Zn (NO is weighed later3)3·6H2O、H3For BTC in small beaker, the accurate DMF that measures, will be anti-in in above-mentioned small beaker
It answers presoma to be placed in ultrasonic cleaning machine to be ultrasonically treated, mixes well dissolution；
Precursors are slowly dropped into the in the mixed solvent stablized in reaction temperature, under fixed temperature, fixed rotating speed
Reaction stops heating after reaction, continues to stir, make its cooled to room temperature；
By solution ultrasonic disperse it is uniform after be transferred to centrifugal treating in centrifuge tube, finally with ethyl alcohol, distillation water washing, then
It dries in a vacuum drying oven, Zn-MOFs Organometallic framework material can be obtained.
As a preference of the present invention, the material that the substrate layer is chosen is polyethylene terephthalate；The electrode layer
Including working electrode, to electrode, reference electrode；The material of the insulating layer is polyacrylic resin；The display layer is adopted
Material is Y3Al5O12, forms display according to the excitation wavelength that the variation of resistivity changes material.
As present invention further optimization, the working electrode is nano silver modified electrode, and described is platinum filament to electrode,
The reference electrode is saturated calomel electrode.
Second object of the present invention is to provide a kind of preparation of blood glucose sensor based on metallic zinc organic transistor
Method, to solve the technical problem of existing sensor preparation process complexity.
In order to achieve the above-mentioned object of the invention, The technical solution adopted by the invention is as follows:
A kind of preparation method of the blood glucose sensor based on metallic zinc organic transistor, comprising the following steps:
Step S1, substrate layer of polyethylene terephthalate's material as sensor is selected；
Step S2, nano silver is added drop-wise on basal electrode by preparation work electrode, is weighed silver nitrate and is added to EminBF4
In ionic liquid, electrolyte is made, the electro-deposition on basal electrode, then electrode be dried under infrared lamp up to working
Electrode；
Step S3, Zn-MOFs Organometallic framework material is prepared, the reaction zone using electrochemical deposition method in electrode layer plates
One layer of Zn-MOFs Organometallic framework material of film forms Zn-MOFs organic metal transistor, to complete the preparation of reagent layer；
Wherein, the preparation process of the preparation of the Zn-MOFs Organometallic framework material is the following steps are included: weigh to benzene
1molL is slowly added dropwise in small beaker in dioctyl phthalate thereto-1Sodium hydroxide solution is sufficiently stirred mixing and makes it dissolve, then uses
1mol·L-1Precursor solution is made to neutrality in hydrochloric acid solution tune pH；Zn (Ac) is weighed later2·2H2O in a round bottom flask,
Deionized water is added thereto, ultrasound makes it dissolve, and CTAB is then added in wherein, is stirred at room temperature, and dissolution is mixed well,
Mixed solution is made；The precursor solution of above-mentioned preparation is slowly added drop-wise in mixed solution, certain time is stirred, it will is generated
Solution is being centrifuged by a large amount of white precipitates after reaction, uses ethyl alcohol, distillation water washing respectively, then in a vacuum drying oven
It is dry, Zn-MOFs Organometallic framework material can be obtained；
Or, weighing sodium acetate, PVP in a round bottom flask, DMF, dehydrated alcohol, deionized water are measured in above-mentioned round-bottomed flask
In；The round-bottomed flask for filling mixed solvent is placed in ultrasonic cleaning machine and is ultrasonically treated, is mixed well, transfers to and has been warmed up
Into the oil bath of reaction temperature, keeps temperature and stir；Zn (NO is weighed later3)3·6H2O、H3BTC is in small beaker, accurately
DMF is measured in above-mentioned small beaker, precursors are placed in ultrasonic cleaning machine and are ultrasonically treated, dissolution is mixed well；It will be anti-
It answers presoma to be slowly dropped into the in the mixed solvent stablized in reaction temperature, is reacted under fixed temperature, fixed rotating speed, reaction terminates
Stop heating afterwards, continues to stir, make its cooled to room temperature；By solution ultrasonic disperse it is uniform after be transferred in centrifuge tube and be centrifuged
Then processing is dried in a vacuum drying oven finally with ethyl alcohol, distillation water washing, can obtain Zn-MOFs organometallic skeletal material
Material；
Step S4, coated with nano rare earth material Y3AI5O12 forms display layer, is connected by electrode with other function layer, leads to
It crosses electronics transfer and realizes display；
Step S5, each functional layer is packaged, and is chosen insulating materials and is packaged to form sensor.
As a preference of the present invention, the basal electrode selects ITO electro-conductive glass.
The advantages of the present invention are:
(1) sensor reagent layer choosing provided by the invention Zn metal organic framework crystal, due to Zn-MOFs framework material
For porous nano, and the structure with high-sequential makes itself and determinand height knot by the adjustable internal environment of chemical synthesis
It closes, the rapid osmotic and raising enzyme immobilizatio ratio and activity to tested sample keep having larger benefit, have blood sampling
Amount is few, high sensitivity, the high advantage of precision；In addition, also can be reduced reagent layer thickness as reagent layer using Zn-MOFs skeleton
Degree improves detection speed to optimize entire Zn transistor sensor thickness.
(2) sensor provided by the invention has abandoned complicated chemical process and has damaged serious drawback to enzymatic activity, not only contracts
Short mass transfer time and electron transmission distance take in terms of the enhanced sensitivity mechanism for playing nano material and holding sensor consistency two
It must balance, the blood glucose sensor function admirable prepared meets national standard, there is higher application value.
(3) sensor provided by the invention is to meet People's Republic of China's semiconductor transducer industry national standard
System is designed on the basis of " part GB/T20521-2006 semiconductor devices 14-1: semiconductor transducer-general provisions and classification "
It makes, structure is simple, and material selection is advanced, and performance indicator is stablized, and produces process stabilizing in enormous quantities, is conducive to industrial application.
(4) the nano material Zn-MOFs metal organic framework and chemically modified electrode of forefront are incorporated in one by the present invention
It rises, prepares novel electrochemical sensor, the reproducibility, stability, sensitivity of measurement can be improved, avoid blood loss or not
Enough phenomenons improve the accuracy of detection, also reduce the complexity of sensor preparation process, improve the quality of product, realize skill
The common progress of art innovation and economic development plays facilitation for the application of Mirae Corp..
Detailed description of the invention
Fig. 1 is the structural schematic diagram of inventive sensor.
Specific embodiment
To make the objectives, technical solutions, and advantages of the present invention more comprehensible, preferred embodiment is enumerated below, to this hair
Bright further description.
Blood glucose sensor of the embodiment 1 based on metallic zinc organic transistor
Referring to Fig. 1, the blood glucose sensor provided by the invention based on metallic zinc organic transistor, including substrate layer 1, be located at
Electrode layer 2 on substrate layer, the insulating layer 3 on electrode layer, the reagent layer 4 on insulating layer, on reagent layer
Display layer 5；
Wherein, the material that the substrate layer is chosen is polyethylene terephthalate；The electrode layer includes working electrode
(nano silver modified electrode), to electrode (platinum filament), reference electrode (saturated calomel electrode)；The material of the insulating layer is polypropylene
Acid resin；The material of the reagent layer is Zn-MOFs Organometallic framework material；Material used by the display layer is
Y3Al5O12 forms display according to the excitation wavelength that the variation of resistivity changes material；
The preparation process of the Zn-MOFs Organometallic framework material the following steps are included:
0.6640g terephthalic acid (TPA) is accurately weighed in small beaker with assay balance, and 1molL is slowly added dropwise thereto-1
Sodium hydroxide solution is sufficiently stirred mixing and makes it dissolve, then uses 1molL-1It is molten that presoma is made to neutrality in hydrochloric acid solution tune pH
Liquid；
0.3290gZn (Ac) is accurately weighed with assay balance2·2H2O in a round bottom flask, thereto be added 25mL go from
Sub- water, ultrasonic 5min, makes it dissolve, and then adds 1gCTAB in wherein, stirs 30min at room temperature, mixes well dissolution, system
Obtain mixed solution；
The precursor solution of above-mentioned preparation is slowly added drop-wise in mixed solution, certain time is stirred, it will is generated a large amount of
White precipitate, after reaction by solution in 8000rmin-1Lower centrifugation 5min uses ethyl alcohol, distillation water washing 5 times, so respectively
The dry 12h in 40 DEG C of vacuum oven afterwards, can be obtained white solid powder, i.e. Zn-MOFs Organometallic framework material.
When using the sensor, sample to be tested (reagent layer) in organic transistor can directly be added dropwise and carry out element knowledge
Not, the molecule of sample to be tested is therefrom separated, record forms access to electrode and working electrode and electric current reaches setting valve
Time when value, and record that working electrode and reference electrode form access and electric current reaches time of setting threshold values, it is surveyed
Examination.
Blood glucose sensor of the embodiment 2 based on metallic zinc organic transistor
Identical as the structure of 1 sensor of embodiment, difference is the preparation work of the Zn-MOFs Organometallic framework material
Skill the following steps are included:
0.3200g sodium acetate, 0.7284g PVP are accurately weighed in 250mL round-bottomed flask with assay balance, use liquid relief
Accurate 27.52mL DMF, 20.35mL dehydrated alcohol, the 20.35mL deionized water of measuring of pipe is in above-mentioned round-bottomed flask；It will fill
The round-bottomed flask of mixed solvent is placed in ultrasonic cleaning machine, and ultrasonic 5min is mixed well, and is transferred to and is had been preheated with reaction temperature
In the oil bath of 80 DEG C of degree, keeps temperature and stir；
0.0331gZn (NO is accurately weighed with assay balance3)3·6H2O、0.0156gH3BTC makes in 10mL small beaker
2mL DMF is accurately measured with pipette in above-mentioned small beaker, precursors is placed in ultrasonic cleaning machine, ultrasonic 5min,
Mix well dissolution；
Precursors are slowly dropped into the in the mixed solvent stablized in reaction temperature with dropper, wash examination with 3mL DMF
Pipe, and cleaning solution is also slowly dropped into the mixed solvent, it is kept fixed 80 DEG C of temperature, fixed rotating speed 800rmin-1Reaction is for 24 hours；
After stop heating, continue to stir, make its cooled to room temperature, solution ultrasonic disperse is uniformly then transferred to centrifuge tube
In, in 8000rmin-1Then lower centrifugation 5min is done respectively with ethyl alcohol, distillation water washing 3 times in 60 DEG C of vacuum ovens
White solid powder, i.e. Zn-MOFs Organometallic framework material can be obtained in dry 12h.
The preparation method of blood glucose sensor of the embodiment 3 based on metallic zinc organic transistor
A kind of preparation method of the blood glucose sensor based on metallic zinc organic transistor, comprising the following steps:
Step S1, substrate layer of polyethylene terephthalate's material as sensor is selected；
Step S2, nano silver is added drop-wise on basal electrode (selecting ITO as basal electrode), claims by preparation work electrode
It takes silver nitrate to be added in EminBF4 ionic liquid, electrolyte is made, the electro-deposition on ito glass, then electrode carried out infrared
It is dried under lamp up to working electrode；
Step S3, Zn-MOFs Organometallic framework material is prepared, the reaction zone using electrochemical deposition method in electrode layer plates
One layer of Zn-MOFs Organometallic framework material of film forms Zn-MOFs organic metal transistor, to complete the preparation of reagent layer；
Wherein, the preparation process of the preparation of the Zn-MOFs Organometallic framework material is the following steps are included: with analysis day
It is flat to accurately weigh 0.6640g terephthalic acid (TPA) in small beaker, 1molL is slowly added dropwise thereto-1Sodium hydroxide solution, sufficiently
It stirs and evenly mixs and makes it dissolve, then use 1molL-1Precursor solution is made to neutrality in hydrochloric acid solution tune pH；
0.3290gZn (Ac) is accurately weighed with assay balance2·2H2O in a round bottom flask, thereto be added 25mL go from
Sub- water, ultrasonic 5min, makes it dissolve, and then adds 1gCTAB in wherein, stirs 30min at room temperature, mixes well dissolution, system
Obtain mixed solution；
The precursor solution of above-mentioned preparation is slowly added drop-wise in mixed solution, certain time is stirred, it will is generated a large amount of
White precipitate, after reaction by solution in 8000rmin-1Lower centrifugation 5min uses ethyl alcohol, distillation water washing 5 times, so respectively
The dry 12h in 40 DEG C of vacuum oven afterwards, can be obtained white solid powder, i.e. Zn-MOFs Organometallic framework material；
Step S4, coated with nano rare earth material Y3AI5O12 forms display layer, is connected by electrode with other function layer, leads to
It crosses electronics transfer and realizes display；
Step S5, each functional layer is packaged, and is chosen insulating materials and is packaged to form sensor.
The present invention prepares Zn nano field-effect organic metal transistor in the above manner, is added dropwise with glucose oxidase
It is modified to reagent layer, detects the glucose content in blood；Display layer is made of Nano Rare-earth Materials Y3Al5O12, according to
Electronics transfer is generated, the excitation wavelength of Y3Al5O12 is changed, chemical signal is transformed by electric signal by electrode, realizes display；
The substrate layer and electrode layer, electrode layer and insulating layer, insulating layer and reagent layer, between reagent layer and display layer respectively containing by
The articulamentum of nano silver wire producing；The substrate layer and insulating layer, respectively articulamentum between layers is all made of stacking route
Manufacturing process connection.
The preparation method of blood glucose sensor of the embodiment 4 based on metallic zinc organic transistor
A kind of preparation method of the blood glucose sensor based on metallic zinc organic transistor, comprising the following steps:
Step S1, substrate layer of polyethylene terephthalate's material as sensor is selected；
Step S2, nano silver is added drop-wise on basal electrode (selecting ITO as basal electrode), claims by preparation work electrode
It takes silver nitrate to be added in EminBF4 ionic liquid, electrolyte is made, the electro-deposition on ito glass, then electrode carried out infrared
It is dried under lamp up to working electrode；
Step S3, Zn-MOFs Organometallic framework material is prepared, the reaction zone using electrochemical deposition method in electrode layer plates
One layer of Zn-MOFs Organometallic framework material of film forms Zn-MOFs organic metal transistor, to complete the preparation of reagent layer；
Wherein, the preparation of the Zn-MOFs Organometallic framework material preparation process the following steps are included:
0.3200g sodium acetate, 0.7284g PVP are accurately weighed in 250mL round-bottomed flask with assay balance, use liquid relief
Accurate 27.52mL DMF, 20.35mL dehydrated alcohol, the 20.35mL deionized water of measuring of pipe is in above-mentioned round-bottomed flask.It will fill
The round-bottomed flask of mixed solvent is placed in ultrasonic cleaning machine, and ultrasonic 5min is mixed well, and is transferred to and is had been preheated with reaction temperature
In the oil bath of 80 DEG C of degree, keeps temperature and stir；
0.0331gZn (NO3) 36H2O, 0.0156gH3BTC is accurately weighed in 10mL small beaker with assay balance.Make
2mL DMF is accurately measured with pipette in above-mentioned small beaker.Precursors are placed in ultrasonic cleaning machine, ultrasonic 5min,
Mix well dissolution；
Precursors are slowly dropped into the in the mixed solvent stablized in reaction temperature with dropper, wash examination with 3mL DMF
Pipe, and cleaning solution is also slowly dropped into the mixed solvent.It is kept fixed 80 DEG C of temperature, fixed rotating speed 800rmin-1 reaction
For 24 hours, stop heating after, continue to stir, make its cooled to room temperature；Then by solution ultrasonic disperse be uniformly transferred to from
In heart pipe, it is centrifuged 5min at 8000rmin-1, ethyl alcohol, distillation water washing 3 times is used respectively, then in 60 DEG C of vacuum ovens
White solid powder, i.e. Zn-MOFs Organometallic framework material can be obtained in middle dry 12h；
Step S4, coated with nano rare earth material Y3AI5O12 forms display layer, is connected by electrode with other function layer, leads to
It crosses electronics transfer and realizes display；
Step S5, each functional layer is packaged, and is chosen insulating materials and is packaged to form sensor.
The present invention prepares Zn nano field-effect organic transistor in the above manner, is added drop-wise to examination with glucose oxidase
Oxidant layer is modified, and the glucose content in blood is detected.Display layer is made of Nano Rare-earth Materials Y3AI5O12, according to generation
Electronics transfer changes the excitation wavelength of Y3AI5O12, and chemical signal is transformed into electric signal by electrode, realizes display.It is described
Contain respectively between substrate layer and electrode layer, electrode layer and insulating layer, insulating layer and reagent layer, reagent layer and display layer and is received by silver
The articulamentum of rice wire producing；The substrate layer and insulating layer, respectively articulamentum between layers, which is all made of, stacks route manufacture
Technique connection.
The present invention is based on the working principles of the blood-sugar detection sensor of metal Zn metal organic transistor: will test when use
Blood is added drop-wise in reagent layer, and Zn-MOFs metallic crystal pipe carries out modification transmission to glucose oxidase, utilizes fluorescence signal
The amount to reflect analysans is increased or decreased, electronics transfer is generated by internal-response, is changed chemical signal by electrode
At electric signal, test result is showed in display layer.
Claims (5)
1. a kind of blood glucose sensor based on metallic zinc organic transistor, electrode layer, position including substrate layer, on substrate layer
In the insulating layer on electrode layer, the reagent layer on insulating layer, the display layer on reagent layer；It is characterized in that, described
The material of reagent layer is Zn-MOFs Organometallic framework material；
The preparation process of the Zn-MOFs Organometallic framework material the following steps are included:
Terephthalic acid (TPA) is weighed in small beaker, sodium hydroxide solution is slowly added dropwise thereto, mixing is sufficiently stirred and makes it dissolve,
Again with hydrochloric acid solution tune pH to neutrality, precursor solution is made；
Zn (Ac) is weighed later2·2H2In a round bottom flask, deionized water is added in O thereto, and ultrasound makes it dissolve, and then adds again
Enter CTAB in wherein, stir at room temperature, mix well dissolution, mixed solution is made；
The precursor solution of above-mentioned preparation is slowly added drop-wise in mixed solution, certain time is stirred, it will generates a large amount of whites
Solution, is being centrifuged by precipitating after reaction, respectively with ethyl alcohol, distillation water washing, then dries in a vacuum drying oven
Obtain Zn-MOFs Organometallic framework material；
Or, weighing sodium acetate, PVP in a round bottom flask, DMF, dehydrated alcohol, deionized water are measured in above-mentioned round-bottomed flask；
The round-bottomed flask for filling mixed solvent is placed in ultrasonic cleaning machine and is ultrasonically treated, is mixed well, transfers to and has been preheated with
In the oil bath of reaction temperature, keeps temperature and stir；
Zn (NO is weighed later3)3·6H2O、H3BTC is in small beaker, and the accurate DMF that measures is in above-mentioned small beaker, by reaction precursor
Body is placed in ultrasonic cleaning machine and is ultrasonically treated, and mixes well dissolution；
Precursors are slowly dropped into the in the mixed solvent stablized in reaction temperature, are reacted under fixed temperature, fixed rotating speed,
Stop heating after reaction, continues to stir, make its cooled to room temperature；
By solution ultrasonic disperse it is uniform after be transferred to centrifugal treating in centrifuge tube, finally with ethyl alcohol, distillation water washing, then true
It is dry in empty drying box, Zn-MOFs Organometallic framework material can be obtained.
2. a kind of blood glucose sensor based on metallic zinc organic transistor described in claim 1, which is characterized in that the substrate
The material that layer choosing takes is polyethylene terephthalate；The electrode layer includes working electrode, to electrode, reference electrode；It is described
The material of insulating layer is polyacrylic resin；Material used by the display layer is Y3Al5O12, according to the change of resistivity
Change the excitation wavelength formation display for changing material.
3. a kind of blood glucose sensor based on metallic zinc organic transistor described in claim 1, which is characterized in that the work
Electrode is nano silver modified electrode, and described is platinum filament to electrode, and the reference electrode is saturated calomel electrode.
4. the preparation method of as claimed in claim 2 one blood glucose sensor based on metallic zinc organic transistor, which is characterized in that
The following steps are included:
Step S1, substrate layer of polyethylene terephthalate's material as sensor is selected；
Step S2, nano silver is added drop-wise on basal electrode by preparation work electrode, is weighed silver nitrate and is added to EminBF4 ion
In liquid, electrolyte is made, the electro-deposition on basal electrode, then electrode be dried under infrared lamp up to the electricity that works
Pole；
Step S3, prepare Zn-MOFs Organometallic framework material, using electrochemical deposition method electrode layer reaction zone plated film one
Layer Zn-MOFs Organometallic framework material, forms Zn-MOFs organic metal transistor, to complete the preparation of reagent layer；
Wherein, the preparation process of the preparation of the Zn-MOFs Organometallic framework material is the following steps are included: weigh terephthaldehyde
1molL is slowly added dropwise in small beaker in acid thereto-1Sodium hydroxide solution is sufficiently stirred mixing and makes it dissolve, then uses
1mol·L-1Precursor solution is made to neutrality in hydrochloric acid solution tune pH；Zn (Ac) is weighed later2·2H2O in a round bottom flask,
Deionized water is added thereto, ultrasound makes it dissolve, and CTAB is then added in wherein, is stirred at room temperature, and dissolution is mixed well,
Mixed solution is made；The precursor solution of above-mentioned preparation is slowly added drop-wise in mixed solution, certain time is stirred, it will is generated
Solution is being centrifuged by a large amount of white precipitates after reaction, uses ethyl alcohol, distillation water washing respectively, then in a vacuum drying oven
It is dry, Zn-MOFs Organometallic framework material can be obtained；
Or, weighing sodium acetate, PVP in a round bottom flask, DMF, dehydrated alcohol, deionized water are measured in above-mentioned round-bottomed flask；
The round-bottomed flask for filling mixed solvent is placed in ultrasonic cleaning machine and is ultrasonically treated, is mixed well, transfers to and has been preheated with
In the oil bath of reaction temperature, keeps temperature and stir；Zn (NO is weighed later3)3·6H2O、H3BTC is in small beaker, correct amount
It takes DMF in above-mentioned small beaker, precursors is placed in ultrasonic cleaning machine and are ultrasonically treated, mix well dissolution；It will reaction
Presoma is slowly dropped into the in the mixed solvent stablized in reaction temperature, reacts under fixed temperature, fixed rotating speed, after reaction
Stop heating, continues to stir, make its cooled to room temperature；By solution ultrasonic disperse it is uniform after be transferred in centrifuge tube at centrifugation
Then reason is dried in a vacuum drying oven finally with ethyl alcohol, distillation water washing, can obtain Zn-MOFs organometallic skeletal material
Material；
Step S4, coated with nano rare earth material Y3AI5O12 forms display layer, is connected by electrode with other function layer, passes through electricity
Display is realized in son transfer；
Step S5, each functional layer is packaged, and is chosen insulating materials and is packaged to form sensor.
5. the preparation method of as claimed in claim 4 one blood glucose sensor based on metallic zinc organic transistor, which is characterized in that
The basal electrode selects ITO electro-conductive glass.
Priority Applications (1)
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