CN110314275A - Degradable flexible controlled drug delivery devices - Google Patents
Degradable flexible controlled drug delivery devices Download PDFInfo
- Publication number
- CN110314275A CN110314275A CN201910614685.1A CN201910614685A CN110314275A CN 110314275 A CN110314275 A CN 110314275A CN 201910614685 A CN201910614685 A CN 201910614685A CN 110314275 A CN110314275 A CN 110314275A
- Authority
- CN
- China
- Prior art keywords
- drug
- controlled release
- circuit controlled
- release unit
- receiving coil
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
- A61M31/002—Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Dermatology (AREA)
- Medical Informatics (AREA)
- Medicinal Preparation (AREA)
- Media Introduction/Drainage Providing Device (AREA)
Abstract
This disclosure relates to a kind of degradable flexible controlled drug delivery devices.The device carries medicine substrate and capping constitutes multiple load medicine cavities, carries drug solution in each load medicine cavity；Carrying substrates are suspended in the drug solution carried in medicine cavity for carrying corresponding circuit controlled release unit, form chinampa structure；Circuit controlled release unit is used for according to the release for carrying drug target in medicine cavity where the electromagnetic wave control received, each circuit controlled release unit includes energy receiving coil, heating resistor, energy receiving coil is used to generate induced current by electromagentic resonance when receiving the electromagnetic wave corresponding to itself resonant frequency；The heat of generation is acted on drug solution, to promote the release of drug target in drug solution for generating heat under faradic effect by heating resistor.Device provided by the embodiment of the present disclosure can control the release stage by stage of drug, and the release range of scatter of drug is wider, and device is degradable.
Description
Technical field
This disclosure relates to electronic technology field more particularly to a kind of degradable flexible controlled drug delivery devices.
Background technique
With the continuous progress of science and technology, electronic device continues to develop, to electronic device in stability, service life and function shape
The requirement of state etc. is continuously improved.Therefore, it in the designing and manufacturing of electronic device, while pursuing performance, even more chases after
The physical stability of device is sought, this is also one of the reason that electronic waste is seriously polluted at this stage.In a sense electricity
The more stable sub- device the better, the electronic device as used in the electronic equipments such as mobile phone.But biology is implanted into for some needs
The intracorporal some electronic devices of body, if physical aspect is also very stable, then for being implanted into the electricity after electronic device failure
The organism of sub- device just needs to carry out second operation taking-up, brings secondary injury to organism (the especially mankind).Especially
Some electronic devices for not needing to be chronically implanted, such as some drugs of neural restoration process electro photoluminescence device, aftertreatment are slow
Device etc. is released, how to guarantee that it is posted in service stage and inside of human body tissue, can voluntarily be degraded in vivo just after failure
It is particularly important, is current technical problem urgently to be resolved.
Summary of the invention
In view of this, the present disclosure proposes a kind of degradable flexible controlled drug delivery devices.
According to the one side of the disclosure, a kind of degradable flexible controlled drug delivery devices are provided, described device is installed on life
Object body surface and/or in vivo, described device includes: to carry medicine substrate, multiple carrying substrates, multiple circuit controlled release units and capping,
The load medicine substrate and the capping constitute multiple load medicine cavities, carry drug solution in each load medicine cavity, described
It include drug target in drug solution；
Each carrying substrates are for carrying corresponding circuit controlled release unit, the drug solution being suspended in the load medicine cavity
In, form chinampa structure；
Each circuit controlled release unit, for releasing according to carrying drug target in medicine cavity where the electromagnetic wave control received
It puts, each circuit controlled release unit includes energy receiving coil, heating resistor,
The energy receiving coil, for being total to by electromagnetism when receiving the electromagnetic wave corresponding to itself resonant frequency
Vibration generates induced current, and is powered using the circuit controlled release unit that the induced current is place；
The heating resistor generates heat for receiving the induced current, and under the faradic effect, will generate
Heat act on the drug solution, to promote the release of drug target in the drug solution.
For above-mentioned apparatus, in one possible implementation, each circuit controlled release unit further includes capacitor parasitics,
The capacitor parasitics are connect with the energy receiving coil in the circuit controlled release unit of place, for controlling energy acceptance
The resonant frequency of coil progress electromagentic resonance.
For above-mentioned apparatus, in one possible implementation, each circuit controlled release unit includes the first wire portion, the
Two wire portions and insulation division, first wire portion are connect with second wire portion,
First wire portion is ring-type, constitutes the energy receiving coil；
Second wire portion is extending shape, constitutes the heating resistor；
Be provided with wire branch in second wire portion, the wire branch be located at first wire portion top or
Lower section and there are laps with first wire portion；
The insulation division, positioned at the wire branch and overlapping Chong Die with the wire branch in first wire portion
Between conducting wire, being electrically insulated between the wire branch and the overlapping conductors is realized；
The wire branch, the overlapping conductors and the insulation division, constitute the capacitor parasitics.
For above-mentioned apparatus, in one possible implementation, first wire portion and/or second wire portion
The shape of middle conducting wire is extending shape,
Wherein, the extending shape includes: any one of snakelike, S-shaped.
For above-mentioned apparatus, in one possible implementation, each carrying substrates carried in medicine cavity are also used to carry
The drug target.
For above-mentioned apparatus, in one possible implementation, the drug solution includes a variety of, different pharmaceutical solution
It is set in different load medicine cavities, the resonant frequency of the energy receiving coil in load medicine cavity where different pharmaceutical solution is different.
For above-mentioned apparatus, in one possible implementation, the resonant frequency of the energy receiving coil is in mesh
In the inhibition frequency range for marking tumour cell,
The energy receiving coil is also used to pass through electromagnetism when receiving the electromagnetic wave corresponding to itself resonant frequency
Resonance inhibits the proliferation of the target tumor.
For above-mentioned apparatus, in one possible implementation, when described device is implanted in the organism, institute
Stating device can degrade in the organism.
For above-mentioned apparatus, in one possible implementation, the material of described device includes degradation material,
Wherein, it is described carry medicine substrate, the carrying substrates, the capping material include flexible degradation material, it is described
Flexible degradation material includes polylactic acid, poly lactic-co-glycolic acid is copolymerized, polylactic acid-polytrimethylene carbonate is total to poly or poly second
At least one of enol and fibroin,
The material of the multiple circuit controlled release unit includes at least one of iron, magnesium, zinc, molybdenum,
The material of insulation division includes at least one of silica, magnesia.
For above-mentioned apparatus, in one possible implementation, carrying substrates include substrate top and substrate lower part, institute
Substrate top and the substrate lower part are stated for clamping the circuit controlled release unit.
Degradable flexible controlled drug delivery devices provided by the embodiment of the present disclosure include: carry medicine substrate, multiple carrying substrates,
Multiple circuit controlled release units and capping, carry medicine substrate and capping constitutes multiple load medicine cavities, and it is molten to carry drug in each load medicine cavity
Liquid includes drug target in drug solution；Each carrying substrates are suspended in load medicine for carrying corresponding circuit controlled release unit
In intracavitary drug solution, chinampa structure is formed；Each circuit controlled release unit, for according to where the electromagnetic wave control received
The release of drug target in medicine cavity is carried, each circuit controlled release unit includes energy receiving coil, heating resistor, energy receiving coil
For generating induced current by electromagentic resonance, and utilize induction when receiving the electromagnetic wave corresponding to itself resonant frequency
Electric current is that the circuit controlled release unit at place is powered；Heating resistor is issued for receiving induced current, and in faradic effect
The heat of generation is acted on drug solution by heat, to promote the release of drug target in drug solution.It can be with external emission difference
The release stage by stage of the electromagnetic wave control drug of frequency, to discharge different drugs in the different stages, and is promoted by heating
The release of drug is more preferable to the function and effect of organism so that the range of scatter of drug is wider.Device is in use in life
Stability and high reliablity in object, drug releases in device finish after can be degraded into vivo it is harmless to organism
Small molecule and as the metabolism of organism excludes external, without being taken out the second operation of device, will not be biology
Body brings additional wound.Device it is applied widely, different drug can carried according to actual needs.And the knot of device
Structure is simple, is advantageously implemented extensive, batch micro operations.
According to below with reference to the accompanying drawings to detailed description of illustrative embodiments, the other feature and aspect of the disclosure will become
It is clear.
Detailed description of the invention
Comprising in the description and constituting the attached drawing of part of specification and specification together illustrates the disclosure
Exemplary embodiment, feature and aspect, and for explaining the principles of this disclosure.
Fig. 1, Fig. 2 shows the structural schematic diagrams according to the degradable flexible controlled drug delivery devices of one embodiment of the disclosure.
Fig. 3 shows the structural schematic diagram of the capping of the degradable flexible controlled drug delivery devices according to one embodiment of the disclosure.
Fig. 4 shows the structural representation of the load medicine substrate according to the degradable flexible controlled drug delivery devices of one embodiment of the disclosure
Figure.
Fig. 5 shows the medicine controlled releasing schematic diagram of the degradable flexible controlled drug delivery devices according to one embodiment of the disclosure.
Fig. 6 shows the structure of the circuit controlled release unit of the degradable flexible controlled drug delivery devices according to one embodiment of the disclosure
Schematic diagram.
Fig. 7 shows the structural schematic diagram of the degradable flexible controlled drug delivery devices according to one embodiment of the disclosure.
Specific embodiment
Various exemplary embodiments, feature and the aspect of the disclosure are described in detail below with reference to attached drawing.It is identical in attached drawing
Appended drawing reference indicate element functionally identical or similar.Although the various aspects of embodiment are shown in the attached drawings, remove
It non-specifically points out, it is not necessary to attached drawing drawn to scale.
Dedicated word " exemplary " means " being used as example, embodiment or illustrative " herein.Here as " exemplary "
Illustrated any embodiment should not necessarily be construed as preferred or advantageous over other embodiments.
In addition, giving numerous details in specific embodiment below to better illustrate the disclosure.
It will be appreciated by those skilled in the art that without certain details, the disclosure equally be can be implemented.In some instances, for
Method, means, element and circuit well known to those skilled in the art are not described in detail, in order to highlight the purport of the disclosure.
Fig. 1, Fig. 2 shows the structural schematic diagrams according to the degradable flexible controlled drug delivery devices of one embodiment of the disclosure.Fig. 3
The structural schematic diagram of the capping of degradable flexible controlled drug delivery devices according to one embodiment of the disclosure is shown.Fig. 4 shows basis
The structural schematic diagram of the load medicine substrate of the degradable flexible controlled drug delivery devices of one embodiment of the disclosure.Fig. 5 is shown according to this public affairs
Open the medicine controlled releasing schematic diagram of the degradable flexible controlled drug delivery devices of an embodiment.As Figure 1-Figure 5, device is installed on life
Object body surface and/or in vivo, the device include: carry medicine substrate 2, multiple carrying substrates 3, multiple circuit controlled release units and capping 1.
It carries medicine substrate 2 and capping 1 constitutes multiple load medicine cavities 7, carry drug solution, drug solution in each load medicine cavity 7
In include drug target.Each carrying substrates 3 are suspended in the medicine carried in medicine cavity 7 for carrying corresponding circuit controlled release unit
In object solution, chinampa structure is formed.Each circuit controlled release unit, for being carried in medicine cavity according to where the electromagnetic wave control received
The release of drug target, each circuit controlled release unit include energy receiving coil 4, heating resistor 5.As shown in figure 5, energy acceptance
Coil 4 is used to receive the electromagnetic wave (transmitting of the emitters such as outside energy transmitting coil) corresponding to itself resonant frequency
When, induced current is generated by electromagentic resonance, and power using the circuit controlled release unit that induced current is place.Heating resistor 5
It generates heat for receiving induced current, and under faradic effect, the heat of generation is acted on into drug solution, to promote medicine
The release of drug target in object solution.
In the present embodiment, it can according to need and the content of drug target, ingredient in drug solution be configured.The dress
Setting can be applied in the organisms such as human body, animal.For example, the device can be implanted into for the patient for suffering from glioma
Patient's brain, drug target can be Mo Siting, lomustine, Temozolomide, Nimustine, taxol etc., with to patient into
Row treatment.Those skilled in the art can according to actual needs be configured drug target, the disclosure to this with no restriction.
In one possible implementation, drug solution may include a variety of, and different pharmaceutical solution is set to different
It carries in medicine cavity 7, the resonant frequency of the energy receiving coil 4 in load medicine cavity 7 where different pharmaceutical solution is different.
In this embodiment it is assumed that device includes 5 load medicine cavities (as shown in Figure 1), five kinds can be placed in carrying medicine cavity
Different drug solutions, different resonant frequencies is arranged in energy receiving coil in each load medicine cavity, such as by the energy of center
The resonant frequency of receiving coil is set as 60KHz, sets the resonant frequency of the energy receiving coil in the upper left corner to 120KHz, inciting somebody to action
The resonant frequency of the energy receiving coil in the upper right corner is set as 180KHz, sets the resonant frequency of the energy receiving coil in the lower left corner
It is set to 240KHz, sets 300KHz for the resonant frequency of the energy receiving coil in the lower right corner.Section is according to medicine in different times
Object discharges demand to the electromagnetic wave of device transmitting different frequency, is such as the electromagnetic wave of 60KHz in first day tranmitting frequency of implantation,
So that center carries the energy receiving coil resonance in medicine cavity and generates induced current, and center is made to carry the hair in medicine cavity
Thermal resistance fever, the heat of generation act on the drug solution in the load medicine cavity of center, promote the release of wherein drug.At it
Time afterwards emits the electromagnetic wave of corresponding frequency respectively, realizes the release of remaining drug.
In the present embodiment, carrying substrates and circuit controlled release unit thereon are suspended in drug solution, formed one it is " floating
Island ", when device is by external force, carrying substrates and circuit controlled release unit under the protection of drug solution, can high degree with it is outer
Strain isolating is realized in power isolation, even if device is larger by external force, circuit controlled release unit can also keep original shape and function, is protected
The stability and reliability of device are demonstrate,proved.
In the present embodiment, heating resistor can not only promote drug release during fever, moreover it is possible to act on disease
The affected part of trouble, treats sufferer.
In the present embodiment, the induction of the resistance value and energy receiving coil 4 of heating resistor 5 generates heat power P and resistance
Size of current is related, P=I2R.Wherein, P is 5 heating power of heating resistor, and I is induced electricity caused by energy receiving coil 4
Stream, R are the resistance value of heating resistor 5.Wherein, R=ρ l/S, wherein ρ is the conductivity for preparing the material of heating resistor 5, and l is hair
The length of 5 resistance wire of thermal resistance, S are the cross-sectional area of corresponding resistance wire.It can by adjusting the length and cross-sectional area of resistance wire
To realize the change of resistance value, thus the heating power of regulation heating resistance as needed.
In one possible implementation, each circuit controlled release unit further includes capacitor parasitics 8, capacitor parasitics 8
It is connect with the energy receiving coil 4 in the circuit controlled release unit of place, carries out being total to for electromagentic resonance for controlling energy receiving coil 4
Vibration frequency.
Degradable flexible controlled drug delivery devices provided by the embodiment of the present disclosure include: carry medicine substrate, multiple carrying substrates,
Multiple circuit controlled release units and capping, carry medicine substrate and capping constitutes multiple load medicine cavities, and it is molten to carry drug in each load medicine cavity
Liquid includes drug target in drug solution；Each carrying substrates are suspended in load medicine for carrying corresponding circuit controlled release unit
In intracavitary drug solution；Each circuit controlled release unit, for carrying target in medicine cavity according to where the electromagnetic wave control received
The release of drug, each circuit controlled release unit include energy receiving coil, heating resistor, and energy receiving coil is for receiving
When electromagnetic wave corresponding to itself resonant frequency, induced current is generated by electromagentic resonance, and be place using induced current
The power supply of circuit controlled release unit；Heating resistor generates heat under faradic effect for receiving induced current, by the heat of generation
Amount acts on drug solution, to promote the release of drug target in drug solution.It can be with the electromagnetic wave of external emission different frequency
The release stage by stage of drug is controlled, to discharge different drugs in the different stages, and promotes the release of drug to make by heating
The range of scatter for obtaining drug is wider, more preferable to the function and effect of organism.The device stabilization in organism in use
Property and high reliablity, drug releases in device finish after can be degraded into the small molecule harmless to organism in vivo, and
As the metabolism of organism excludes in vitro, without being taken out the second operation of device, will not be brought additionally for organism
Wound.Device it is applied widely, different drug can carried according to actual needs.And the structure of device is simple, has
The extensive, batch micro operations conducive to realization.
Fig. 6 shows the structure of the circuit controlled release unit of the degradable flexible controlled drug delivery devices according to one embodiment of the disclosure
Schematic diagram.Fig. 7 shows the structural schematic diagram of the degradable flexible controlled drug delivery devices according to one embodiment of the disclosure.One kind can
Can implementation in, as shown in Figure 6, Figure 7, each circuit controlled release unit include the first wire portion S1, the second wire portion S2 and
Insulation division 6, the first wire portion S1 are connect with the second wire portion S2.First wire portion S1 is ring-type, constitutes energy receiving coil 4.
Second wire portion S2 is extending shape, constitutes heating resistor 5.Wire branch S2 ', conducting wire point are provided in second wire portion S2
Branch S2 ' is located above or below the first wire portion S1 and there are laps with the first wire portion S1.Insulation division 6, which is located at, leads
Between line branch S2 ' and overlapping conductors S1 ' Chong Die with wire branch S2 ' in the first wire portion S1, realize wire branch S2 ' with
Electrical isolation between overlapping conductors S1 '.Wire branch S2 ', overlapping conductors S1 ' and insulation division 6 constitute capacitor parasitics 8.
By the above-mentioned means, circuit controlled release unit directly can be prepared by lithographic technique, without needed for being prepared separately
Capacitor parasitics, simplify device process, reduce the manufacture difficulty of device.
In this implementation, the extending shape of the second wire portion S2 may include the extendable shape such as snakelike, S-shaped
The tensile property of heating resistor can be improved in shape in this way, improves the reliability and stability of heating resistor.Constitute energy acceptance line
The annular shape of first wire portion of circle can be the shapes such as " returning " font, annulus shape.Those skilled in the art can basis
Actual needs the shape of heating resistor and energy receiving coil is configured, the disclosure to this with no restriction.
In the present embodiment, the resonant frequency of circuit is under the action of energy receiving coil 4Wherein, f
For resonant frequency, L is the inductance of energy receiving coil 4, and C is the capacitor of capacitor parasitics 8.By adjusting energy receiving coil 4
With the dimensional parameters of heating resistor 5 and insulation division 6, the capacitor of adjustable capacitor parasitics 8, to change being total to for reorganization circuit
Vibration frequency.And the capacitor of capacitor parasiticsWherein, εrFor the dielectric constant of 6 material therefor of insulation division.S0For energy
The overlapping area of receiving coil 4 and heating resistor 5, namely be exactly the effective area of capacitor parasitics 8.D is 8 liang of capacitor parasitics
The thickness of insulation division 6 between the distance between electrode, that is, energy receiving coil 4 and heating resistor 5.Those skilled in the art
Member can be according to actual needs to L, εr、S0, d be adjusted, it is final to realize multiple groups circuit controlled release unit in corresponding resonant frequency
Lower work, to carry out the release of different pharmaceutical in the corresponding period.
In one possible implementation, capacitor parasitics, this public affairs can also be separately provided in circuit controlled release unit
It opens to this with no restriction.
In one possible implementation, as shown in fig. 6, conducting wire in the first wire portion S1 and/or the second wire portion S2
Shape be extending shape.Wherein, extending shape may include: any one of snakelike, S-shaped.
In this implementation, the shape of conducting wire can be an individual conducting wire in the first wire portion and the second wire portion
Shape, set extending shape for the conducting wire of the first wire portion and the second wire portion, in its stress, for conducting wire by turn
Dynamic that variations is waited to provide strong guarantee to offset strain, to achieve the purpose that protect conducting wire, improving whole device makes
With stability and reliability in the process.Those skilled in the art can according to actual needs be configured the shape of conducting wire,
The disclosure to this with no restriction.
In one possible implementation, each carrying substrates 3 carried in medicine cavity 7 are also used to carry drug target.
In this implementation, carrying substrates can carry drug.The drug carried in medicine cavity also can be absorbed in carrying substrates
Solution, after absorbing the drug solution carried in medicine cavity, since heating resistor fever promotes the drug release on carrying substrates, simultaneously
Carrying substrates, since the drug concentration in surrounding load medicine cavity is higher, are formed since drug diffusion makes the reduction of drug concentration thereon
Certain drug concentration gradient promotes carrying substrates further to absorb the drug for carrying medicine cavity, to form a positive drug
Release cycle promotes drug release.
In one possible implementation, the resonant frequency of energy receiving coil 4 is in the inhibition of target tumor
In frequency range.Energy receiving coil 4 is also used to pass through electromagnetism when receiving the electromagnetic wave corresponding to itself resonant frequency
Resonance inhibits the proliferation of target tumor.
In this implementation, inhomogeneous tumour cell is under the Electromagnetic Field of specific frequency, growth and breeding meeting
It is suppressed to a certain extent, can according to need the resonant frequency of adjustment energy receiving coil 4, keep it certain in resonance
Inhibit the proliferation of tumour cell in degree.For example, being arranged resonant frequency within the scope of 100KHz-1MHz.Those skilled in the art
Member can need to be configured resonant frequency according to the practical inhibition of tumour cell, the disclosure to this with no restriction.
In one possible implementation, as shown in Fig. 2, Fig. 7, carrying substrates 3 may include substrate top and substrate
Lower part, substrate top and substrate lower part are for clamping circuit controlled release unit.
In this implementation, carrying substrates can by way of clamping bearer circuit controlled release unit, can also pass through
The modes such as package realize the carrying of circuit controlled release unit, the disclosure to this with no restriction.
In one possible implementation, when device is implanted in organism, device can degrade in vivo.
In one possible implementation, the material of device may include degradation material.Wherein, it carries medicine substrate, hold
Carry substrate, capping material may include flexible degradation material, flexible degradation material includes polylactic acid (polylactic
Acid, abbreviation PLA), poly lactic-co-glycolic acid copolymerization (poly lactic-co-glycolic acid, abbreviation PLGA), poly- cream
Acid-polytrimethylene carbonate is copolymerized (PLA-PTMC), polyvinyl alcohol (polyvinyl alcohol, vinylalcohol
At least one of polymer, abbreviation PVA) and fibroin.The material of multiple circuit controlled release units may include iron, magnesium, zinc,
At least one of molybdenum.The material of insulation division may include at least one of silica, magnesia.
In this implementation, the duration that can need to keep steady-working state in organism according to device, to dress
The material and size for setting each component are selected, the disclosure to this with no restriction.For example it is assumed that device need to be implanted into human body
Place 3 months, to guarantee the normal release of drug, can choose PLA-PTMC be load medicine substrate, carrying substrates, capping material
Material, metallic zinc are the material of circuit controlled release unit, and magnesia is the material of insulation division, and corresponding size is arranged.
In one possible implementation, the thickness of device can be 1mm-2mm, and length can be 10mm-30mm, wide
Degree can be 10mm-30mm.It can specifically be made according to degradation time needs, the amount of drug solution, position of organism implantation etc.
Be configured with size of the information of scene to device, the disclosure to this with no restriction.
In one possible implementation, device can be set to the arbitrary shapes such as petal-shaped, and the disclosure does not make this
Limitation.
The disclosure also provides a kind of method for preparing section components in above-mentioned apparatus, can be first in hard substrate using more
The technique of secondary deposition film and photoetching, preparation complete energy receiving coil 4, insulation division 6, heating resistor 5, obtain circuit controlled release list
Then member is transferred on carrying substrates 3 by transfer technique.Wherein, carrying substrates, can be first by PLA- during preparation
PTMC (the preparing material of carrying substrates) solution before curing and the progress of corresponding drug target are miscible, then to mixed liquid
Into solidification, to form the carrying substrates for having drug target.
It should be noted that although describing degradable flexible controlled drug delivery devices using above-described embodiment as example such as
On, it is understood by one of ordinary skill in the art that the disclosure answer it is without being limited thereto.In fact, user completely can according to personal preference and/
Or practical application scene flexibly sets each component, as long as meeting the technical solution of the disclosure.
The presently disclosed embodiments is described above, above description is exemplary, and non-exclusive, and
It is not limited to disclosed each embodiment.Without departing from the scope and spirit of illustrated each embodiment, for this skill
Many modifications and changes are obvious for the those of ordinary skill in art field.The selection of term used herein, purport
In the principle, practical application or technological improvement to the technology in market for best explaining each embodiment, or lead this technology
Other those of ordinary skill in domain can understand each embodiment disclosed herein.
Claims (10)
1. a kind of degradable flexible controlled drug delivery devices, which is characterized in that described device is installed on organism body surface and/or body
Interior, described device includes: to carry medicine substrate, multiple carrying substrates, multiple circuit controlled release units and capping,
The load medicine substrate and the capping constitute multiple load medicine cavities, carry drug solution, the drug in each load medicine cavity
It include drug target in solution；
Each carrying substrates are suspended in the drug solution in the load medicine cavity, shape for carrying corresponding circuit controlled release unit
At chinampa structure；
Each circuit controlled release unit, for carrying the release of drug target in medicine cavity according to the electromagnetic wave control place received, often
A circuit controlled release unit includes energy receiving coil, heating resistor,
The energy receiving coil, for being produced by electromagentic resonance when receiving the electromagnetic wave corresponding to itself resonant frequency
Raw induced current, and powered using the circuit controlled release unit that the induced current is place；
The heating resistor generates heat for receiving the induced current, and under the faradic effect, by the heat of generation
Amount acts on the drug solution, to promote the release of drug target in the drug solution.
2. the apparatus according to claim 1, which is characterized in that each circuit controlled release unit further includes capacitor parasitics,
The capacitor parasitics are connect with the energy receiving coil in the circuit controlled release unit of place, for controlling energy receiving coil
Carry out the resonant frequency of electromagentic resonance.
3. the apparatus of claim 2, which is characterized in that each circuit controlled release unit includes the first wire portion, second
Wire portion and insulation division, first wire portion are connect with second wire portion,
First wire portion is ring-type, constitutes the energy receiving coil；
Second wire portion is extending shape, constitutes the heating resistor；
Be provided with wire branch in second wire portion, the wire branch be located at first wire portion top or under
Just and there are laps with first wire portion；
The insulation division, positioned at the wire branch and overlapping conductors Chong Die with the wire branch in first wire portion
Between, realize being electrically insulated between the wire branch and the overlapping conductors；
The wire branch, the overlapping conductors and the insulation division, constitute the capacitor parasitics.
4. device according to claim 3, which is characterized in that in first wire portion and/or second wire portion
The shape of conducting wire is extending shape,
Wherein, the extending shape includes: any one of snakelike, S-shaped.
5. the apparatus according to claim 1, which is characterized in that each carrying substrates carried in medicine cavity are also used to carry described
Drug target.
6. the apparatus according to claim 1, which is characterized in that the drug solution include it is a variety of, different pharmaceutical solution is set
It is placed in different load medicine cavities, the resonant frequency of the energy receiving coil in load medicine cavity where different pharmaceutical solution is different.
7. the apparatus according to claim 1, which is characterized in that the resonant frequency of the energy receiving coil is swollen in target
In the inhibition frequency range of oncocyte,
The energy receiving coil is also used to pass through electromagentic resonance when receiving the electromagnetic wave corresponding to itself resonant frequency
Inhibit the proliferation of the target tumor.
8. the apparatus according to claim 1, which is characterized in that described when described device is implanted in the organism
Device can degrade in the organism.
9. the apparatus according to claim 1, which is characterized in that the material of described device includes degradation material,
Wherein, it is described carry medicine substrate, the carrying substrates, the capping material include flexible degradation material, the flexibility
Degradation material includes polylactic acid, poly lactic-co-glycolic acid copolymerization, polylactic acid-polytrimethylene carbonate copolymerization, polyvinyl alcohol
At least one of with fibroin,
The material of the multiple circuit controlled release unit includes at least one of iron, magnesium, zinc, molybdenum,
The material of insulation division includes at least one of silica, magnesia.
10. the apparatus according to claim 1, which is characterized in that carrying substrates include substrate top and substrate lower part, described
Substrate top and the substrate lower part are for clamping the circuit controlled release unit.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910614685.1A CN110314275B (en) | 2019-07-09 | 2019-07-09 | Degradable flexible medicine controlled release device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910614685.1A CN110314275B (en) | 2019-07-09 | 2019-07-09 | Degradable flexible medicine controlled release device |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN110314275A true CN110314275A (en) | 2019-10-11 |
| CN110314275B CN110314275B (en) | 2020-04-17 |
Family
ID=68121567
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910614685.1A Active CN110314275B (en) | 2019-07-09 | 2019-07-09 | Degradable flexible medicine controlled release device |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN110314275B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111888643A (en) * | 2020-08-24 | 2020-11-06 | 山东健生道科技发展有限公司 | Device for accelerating absorption of ointment |
Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040265353A1 (en) * | 1995-07-28 | 2004-12-30 | Zars, Inc. | Systems and methods for treating panic attacks |
| CN1748809A (en) * | 2005-08-26 | 2006-03-22 | 东南大学 | Magnetic thermal synergetic electric aid transdermal medicine administration device |
| CN1899644A (en) * | 1998-09-29 | 2007-01-24 | 沙斯公司 | Methods and apparatus for improved administration of pharmaceutically active compounds |
| CN202699847U (en) * | 2012-06-13 | 2013-01-30 | 复旦大学 | Implant type thermochemotherapy device |
| CN105326638A (en) * | 2015-10-26 | 2016-02-17 | 华南理工大学 | Low-power-consumption wearable electromagnetic ultrasonic medicinal moxibustion device |
| WO2018004191A1 (en) * | 2016-06-29 | 2018-01-04 | 서울대학교 산학협력단 | Biosensing device and drug delivery device |
| KR20180011653A (en) * | 2016-07-25 | 2018-02-02 | 서울대학교산학협력단 | Drug delivery device |
| CN107929926A (en) * | 2017-12-14 | 2018-04-20 | 清华大学 | A kind of degradable medicament slow release electronics patch system of implanted |
| KR20180065278A (en) * | 2016-12-07 | 2018-06-18 | 서울대학교산학협력단 | Bioheater |
-
2019
- 2019-07-09 CN CN201910614685.1A patent/CN110314275B/en active Active
Patent Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040265353A1 (en) * | 1995-07-28 | 2004-12-30 | Zars, Inc. | Systems and methods for treating panic attacks |
| CN1899644A (en) * | 1998-09-29 | 2007-01-24 | 沙斯公司 | Methods and apparatus for improved administration of pharmaceutically active compounds |
| CN1748809A (en) * | 2005-08-26 | 2006-03-22 | 东南大学 | Magnetic thermal synergetic electric aid transdermal medicine administration device |
| CN202699847U (en) * | 2012-06-13 | 2013-01-30 | 复旦大学 | Implant type thermochemotherapy device |
| CN105326638A (en) * | 2015-10-26 | 2016-02-17 | 华南理工大学 | Low-power-consumption wearable electromagnetic ultrasonic medicinal moxibustion device |
| WO2018004191A1 (en) * | 2016-06-29 | 2018-01-04 | 서울대학교 산학협력단 | Biosensing device and drug delivery device |
| KR20180011653A (en) * | 2016-07-25 | 2018-02-02 | 서울대학교산학협력단 | Drug delivery device |
| KR20180065278A (en) * | 2016-12-07 | 2018-06-18 | 서울대학교산학협력단 | Bioheater |
| CN107929926A (en) * | 2017-12-14 | 2018-04-20 | 清华大学 | A kind of degradable medicament slow release electronics patch system of implanted |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111888643A (en) * | 2020-08-24 | 2020-11-06 | 山东健生道科技发展有限公司 | Device for accelerating absorption of ointment |
Also Published As
| Publication number | Publication date |
|---|---|
| CN110314275B (en) | 2020-04-17 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP7472264B2 (en) | Application of tumor-treating electric fields (TT fields) via electrodes embedded in skull implants | |
| Cha et al. | Bioresorbable electronic implants: history, materials, fabrication, devices, and clinical applications | |
| CN107929926B (en) | Implantable degradable medicine slow-release electronic patch system | |
| JP7483670B2 (en) | Plasma Applicator | |
| EP1609502B1 (en) | Primary coil with ferrite core for transcutaneous energy transfer | |
| Boutry et al. | Towards biodegradable wireless implants | |
| CN1150869C (en) | Method and device for combined heat treatment of body tissue | |
| EP2208506A1 (en) | Intraluminar oncothermia catheter | |
| KR20170080577A (en) | Device for generating a cold atmospheric pressure plasma | |
| US20140200626A1 (en) | Implantable transient nerve stimulation device | |
| WO2000004946A2 (en) | Treatment using implantable devices | |
| Ma et al. | Stretchable and skin‐attachable electronic device for remotely controlled wearable cancer therapy | |
| WO2002056938A3 (en) | System and method employing indwelling rf catheter for systemic patient warming by application of dielectric heating | |
| US8915904B2 (en) | Implantable device with conforming telemetry coil and methods of making same | |
| CN110314275A (en) | Degradable flexible controlled drug delivery devices | |
| CN108605187A (en) | A kind of human body implanted device | |
| CN103165211A (en) | Pacemaker electrode wire and pacemaker | |
| JP2024514045A (en) | Electrode arrays and methods of manufacturing and using them | |
| CN105326638A (en) | Low-power-consumption wearable electromagnetic ultrasonic medicinal moxibustion device | |
| CN105167833A (en) | In-vivo fixing device for department of orthopaedics | |
| CN201253417Y (en) | Skin electrode with residence physical therapy plaster | |
| CN103157180B (en) | Pacemaker electrode wire and pacemaker | |
| CN204017163U (en) | A kind of electromagnetism harmonic wave sends Target Board and electromagnetism harmonic wave cytothesis therapeutic equipment | |
| KR20220058773A (en) | Paste for producing biodegradable electroceutical, electric device and method of manufacturing the same | |
| CN110464983A (en) | Degradable flexible nerve tract prosthetic device |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |