CN110314135A - 壳聚糖微胶包埋胡萝卜素并改善胡萝卜素稳定性的方法 - Google Patents
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Abstract
本发明涉及一种以壳聚糖微胶为材料包埋胡萝卜素并改善胡萝卜素稳定性的方法。通过壳聚糖与京尼平交联制备微胶溶液，再用微胶溶液乳化包埋胡萝卜素。主要采用分光光度计法检测胡萝卜素在紫外光、三价铁离子及双氧水环境中的保存率，发现壳聚糖微胶包埋的胡萝卜素的稳定性显著提高。本发明中包埋胡萝卜素的材料具有来源简单方便，成本低，天然毒性小，用量少的优点，且包埋后的胡萝卜素的稳定性明显提高，在保健食品及医药行业有广阔的应用前景。
Description
技术领域
本发明涉及壳聚糖微胶溶液制备并包埋胡萝卜素及检测胡萝卜素稳定性的技术领域。
背景技术
胡萝卜素是一种脂溶性功能性物质，不溶于水，易溶于有机溶剂，限制了胡萝卜素在食品、医药行业的应用范围，另外，胡萝卜素分子结构中含有多个共轭双键，对光照、氧气、离子等不稳定，在其运输和储存过程中存在很多问题。近年来，用乳液包埋胡萝卜素达到提高脂溶性胡萝卜素的稳定性、水溶性、生物有效性的目的成为食品科技领域的研究热点之一。大量低分子或高分子表面活性剂常用于稳定乳液，但是，表面活性剂具有一定的生物毒性，不适合应用于食品、医药行业。随之，关于用蛋白、多糖或者蛋白-多糖复合物之类的大分子食品级的物质稳定乳液的研究内容引起越来越多的关注。本发明所用的壳聚糖来源于自然界广泛存在的几丁质脱乙酰化，具有良好的生物相容性、安全性、生物降解性，此外，制备壳聚糖微胶溶液的交联剂是从栀子花中提取的产物——京尼平，是一种优良的天然生物交联剂，毒性远低于其他化学交联剂(如戊二醛)。目前，关于乳化剂研究较多的食品级大分子物质多是果胶、明胶、乳清蛋白、海藻酸盐等，关于壳聚糖-京尼平交联的研究不是很多。
发明内容
本发明旨在提供一种利用天然无毒的壳聚糖微胶包埋胡萝卜素并提高胡萝卜素稳定性的方法：
1、一种以壳聚糖微胶为材料包埋胡萝卜素并改善胡萝卜素稳定性的方法，其特征在于包括以下操作步骤：
(1)将壳聚糖溶于1％醋酸溶液中，调节pH至5.5，再过膜，配制成一定浓度；(2)将京尼平溶于20％乙醇中，配制成一定浓度；
(3)将步骤(1)所得的壳聚糖溶液与步骤(2)所得的京尼平溶液以5∶1的比例混匀后，置于37℃水浴中反应12小时；
(4)称取一定质量的胡萝卜素溶于油中，将步骤(3)所得的壳聚糖微胶溶液与油溶液以一定的体积比混合，利用分散机以10000rpm分散1分钟，形成乳液；
(5)乳液静置半小时后，将乳液置于不同的环境条件下(紫外光，三价铁离子，过氧化氢)处理8小时。
(6)萃取不同样品中的胡萝卜素，在480nm条件下用紫外分光光度计测量吸光值，对比胡萝卜素标曲，计算胡萝卜素的保留率。
壳聚糖溶液与京尼平溶液反应生成蓝色微胶溶液，与溶有胡萝卜素的油相溶液乳化形成乳液，胡萝卜素的含量越高，乳液颜色越深。进过8小时处理，壳聚糖微胶稳定的乳液中所含的胡萝卜素的保留率明显高于直接溶解在油里的胡萝卜素。
2、根据专利要求1所述的一种以壳聚糖微胶为材料包埋胡萝卜素并改善胡萝卜素稳定性的方法，其特征在于：所述步骤(3)的壳聚糖溶液与京尼平溶液以5∶1的比例混匀，在37℃水浴中反应12小时。
附图说明
图1 胡萝卜素在紫外光照条件下8小时的保留率
图2 胡萝卜素在5％过氧化氢条件下8小时的保留率
图3 胡萝卜素在氯化铁存在条件下8小时的保留率
具体实施方式
下面通过实施例，对本发明作进一步描述。
实施例1：
(1)将壳聚糖溶于1％醋酸溶液中，调节pH至5.5，再过膜，配制成一定浓度；(2)将京尼平溶于20％乙醇中，配制成一定浓度；
(3)将步骤(1)所得的壳聚糖溶液与步骤(2)所得的京尼平溶液以5∶1的比例混匀后，置于37℃水浴中反应12小时；
(4)称取一定质量的胡萝卜素溶于油中，将步骤(3)所得的壳聚糖微胶溶液与油溶液以一定的体积比混合，利用分散机以10000rpm分散1分钟，形成乳液；
(5)乳液静置半小时后，将乳液置于不同的环境条件下(紫外光，三价铁离子，过氧化氢)处理8小时。
(6)萃取不同样品中的胡萝卜素，在480nm条件下用紫外分光光度计测量吸光值，对比胡萝卜素标曲，计算胡萝卜素的保留率。
壳聚糖溶液与京尼平溶液反应生成蓝色微胶溶液，与溶有胡萝卜素的油相溶液乳化形成乳液，胡萝卜素的含量越高，乳液颜色越深。进过8小时处理，壳聚糖微胶稳定的乳液中所含的胡萝卜素的保留率明显高于直接溶解在油里的胡萝卜素。
实施例2：
(1)胡萝卜素标曲的测定
称取一定量的胡萝卜素溶解，配制成不同浓度，其浓度梯度为0.1μg/mL、1μg/mL、2.5μg/mL、5μg/mL、10μg/mL，在450nm的波长下，用紫外分光光度计测定相应的吸光值，绘制曲线，拟合方程。
(2)胡萝卜素萃取
称取一定质量的乳液，加入1mL二甲基亚砜，涡旋混匀，12000rpm离心1分钟，取上清液，加入合适体积的正己烷，用分光光度计检测。
从图1～图3可以看出，以壳聚糖微胶溶液为乳化剂的乳液包埋的胡萝卜素在紫外光照、过氧化氢及铁离子条件下的稳定性显著提高。
综上所述仅为本发明的较佳施例而已，并非用来限定本发明的实施范围。即凡依本发明申请专利范围的内容所做的等效变化与修饰都应为本发明的技术范畴。
Claims (2)
1.一种以壳聚糖微胶为材料包埋胡萝卜素并改善胡萝卜素稳定性的方法，其特征在于包括以下操作步骤：
(1)将壳聚糖溶于1％醋酸溶液中，调节pH至5.5，再过膜，配制成一定浓度；(2)将京尼平溶于20％乙醇中，配制成一定浓度；
(3)将步骤(1)所得的壳聚糖溶液与步骤(2)所得的京尼平溶液以5∶1的比例混匀后，置于37℃水浴中反应12小时；
(4)称取一定质量的胡萝卜素溶于油中，将步骤(3)所得的壳聚糖微胶溶液与油溶液以一定的体积比混合，利用分散机以10000rpm分散1分钟，形成乳液；
(5)乳液静置半小时后，将乳液置于不同的环境条件下(紫外光，三价铁离子，过氧化氢)处理8小时。
(6)萃取不同样品中的胡萝卜素，在480nm条件下用紫外分光光度计测量吸光值，对比胡萝卜素标曲，计算胡萝卜素的保留率。
壳聚糖溶液与京尼平溶液反应生成蓝色微胶溶液，与溶有胡萝卜素的油相溶液乳化形成乳液，胡萝卜素的含量越高，乳液颜色越深。进过8小时处理，壳聚糖微胶稳定的乳液中所含的胡萝卜素的保留率明显高于直接溶解在油里的胡萝卜素。
2.根据专利要求1所述的一种以壳聚糖微胶为材料包埋胡萝卜素并改善胡萝卜素稳定性的方法，其特征在于：所述步骤(3)的壳聚糖溶液与京尼平溶液以5∶1的比例混匀，在37℃水浴中反应12小时。
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Cited By (3)
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| CN112869119A (zh) * | 2021-02-19 | 2021-06-01 | 吉林大学 | 一种可以提高β-胡萝卜素稳定性的食品级高内相乳液的制备方法 |
| CN113243529A (zh) * | 2021-04-29 | 2021-08-13 | 东北农业大学 | 一种运载β-胡萝卜素凝胶微球的制备方法 |
| CN114259954A (zh) * | 2021-12-31 | 2022-04-01 | 厦门大学 | 一种封装β-胡萝卜素的壳聚糖-分离乳清蛋白凝胶的制备方法 |
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| CN104522670A (zh) * | 2015-01-13 | 2015-04-22 | 华中农业大学 | 一种红球菌b7740类胡萝卜素的微胶囊制备方法 |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112869119A (zh) * | 2021-02-19 | 2021-06-01 | 吉林大学 | 一种可以提高β-胡萝卜素稳定性的食品级高内相乳液的制备方法 |
| CN113243529A (zh) * | 2021-04-29 | 2021-08-13 | 东北农业大学 | 一种运载β-胡萝卜素凝胶微球的制备方法 |
| CN114259954A (zh) * | 2021-12-31 | 2022-04-01 | 厦门大学 | 一种封装β-胡萝卜素的壳聚糖-分离乳清蛋白凝胶的制备方法 |
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