CN110305272A - A kind of virus shape nano material and its Actinochemical synthesis - Google Patents
A kind of virus shape nano material and its Actinochemical synthesis Download PDFInfo
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- CN110305272A CN110305272A CN201910683797.2A CN201910683797A CN110305272A CN 110305272 A CN110305272 A CN 110305272A CN 201910683797 A CN201910683797 A CN 201910683797A CN 110305272 A CN110305272 A CN 110305272A
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- 239000002086 nanomaterial Substances 0.000 title claims abstract description 44
- 238000003786 synthesis reaction Methods 0.000 title claims abstract description 21
- 230000015572 biosynthetic process Effects 0.000 title claims abstract description 20
- 241000700605 Viruses Species 0.000 title claims description 13
- 230000003612 virological effect Effects 0.000 claims abstract description 29
- 229920000642 polymer Polymers 0.000 claims abstract description 22
- 239000012987 RAFT agent Substances 0.000 claims abstract description 16
- 239000000178 monomer Substances 0.000 claims abstract description 13
- 238000006116 polymerization reaction Methods 0.000 claims abstract description 13
- AISZNMCRXZWVAT-UHFFFAOYSA-N 2-ethylsulfanylcarbothioylsulfanyl-2-methylpropanenitrile Chemical compound CCSC(=S)SC(C)(C)C#N AISZNMCRXZWVAT-UHFFFAOYSA-N 0.000 claims abstract description 12
- 238000001338 self-assembly Methods 0.000 claims abstract description 9
- -1 acrylic ester Chemical class 0.000 claims abstract description 6
- 239000002904 solvent Substances 0.000 claims abstract description 5
- 102400000830 Saposin-B Human genes 0.000 claims abstract description 4
- 101800001697 Saposin-B Proteins 0.000 claims abstract description 4
- 229920000359 diblock copolymer Polymers 0.000 claims abstract description 3
- 239000003153 chemical reaction reagent Substances 0.000 claims description 14
- 230000000977 initiatory effect Effects 0.000 claims description 8
- 239000000463 material Substances 0.000 claims description 4
- LJPTYDNIDAPECW-UHFFFAOYSA-N [Na].CC1=C(C(=O)C2=C(C=CC=C2)P(O)(O)=O)C(=CC(=C1)C)C Chemical compound [Na].CC1=C(C(=O)C2=C(C=CC=C2)P(O)(O)=O)C(=CC(=C1)C)C LJPTYDNIDAPECW-UHFFFAOYSA-N 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 150000001336 alkenes Chemical class 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- VFHVQBAGLAREND-UHFFFAOYSA-N diphenylphosphoryl-(2,4,6-trimethylphenyl)methanone Chemical compound CC1=CC(C)=CC(C)=C1C(=O)P(=O)(C=1C=CC=CC=1)C1=CC=CC=C1 VFHVQBAGLAREND-UHFFFAOYSA-N 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- YMCOIFVFCYKISC-UHFFFAOYSA-N ethoxy-[2-(2,4,6-trimethylbenzoyl)phenyl]phosphinic acid Chemical compound CCOP(O)(=O)c1ccccc1C(=O)c1c(C)cc(C)cc1C YMCOIFVFCYKISC-UHFFFAOYSA-N 0.000 claims 1
- JRZJOMJEPLMPRA-UHFFFAOYSA-N olefin Natural products CCCCCCCC=C JRZJOMJEPLMPRA-UHFFFAOYSA-N 0.000 claims 1
- MPQXHAGKBWFSNV-UHFFFAOYSA-N oxidophosphanium Chemical class [PH3]=O MPQXHAGKBWFSNV-UHFFFAOYSA-N 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 230000006698 induction Effects 0.000 abstract description 3
- 239000002861 polymer material Substances 0.000 abstract description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 18
- 238000006243 chemical reaction Methods 0.000 description 15
- 230000005540 biological transmission Effects 0.000 description 11
- 238000002360 preparation method Methods 0.000 description 10
- 229910052757 nitrogen Inorganic materials 0.000 description 9
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 8
- 150000003384 small molecules Chemical class 0.000 description 6
- 238000000034 method Methods 0.000 description 5
- PSGCQDPCAWOCSH-UHFFFAOYSA-N (4,7,7-trimethyl-3-bicyclo[2.2.1]heptanyl) prop-2-enoate Chemical compound C1CC2(C)C(OC(=O)C=C)CC1C2(C)C PSGCQDPCAWOCSH-UHFFFAOYSA-N 0.000 description 4
- 235000010290 biphenyl Nutrition 0.000 description 4
- 239000004305 biphenyl Substances 0.000 description 4
- 125000006267 biphenyl group Chemical group 0.000 description 4
- 229920001400 block copolymer Polymers 0.000 description 4
- 238000005286 illumination Methods 0.000 description 4
- 229920002521 macromolecule Polymers 0.000 description 4
- 239000012046 mixed solvent Substances 0.000 description 4
- AUONHKJOIZSQGR-UHFFFAOYSA-N oxophosphane Chemical compound P=O AUONHKJOIZSQGR-UHFFFAOYSA-N 0.000 description 4
- ZUOUZKKEUPVFJK-UHFFFAOYSA-N phenylbenzene Natural products C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 description 4
- 238000004321 preservation Methods 0.000 description 4
- 238000007789 sealing Methods 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 3
- 239000001257 hydrogen Substances 0.000 description 3
- 229910052739 hydrogen Inorganic materials 0.000 description 3
- 238000001228 spectrum Methods 0.000 description 3
- BGJSXRVXTHVRSN-UHFFFAOYSA-N 1,3,5-trioxane Chemical compound C1OCOCO1 BGJSXRVXTHVRSN-UHFFFAOYSA-N 0.000 description 2
- HEDRZPFGACZZDS-MICDWDOJSA-N Trichloro(2H)methane Chemical compound [2H]C(Cl)(Cl)Cl HEDRZPFGACZZDS-MICDWDOJSA-N 0.000 description 2
- 238000006555 catalytic reaction Methods 0.000 description 2
- 229920001577 copolymer Polymers 0.000 description 2
- 238000013461 design Methods 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- OMNKZBIFPJNNIO-UHFFFAOYSA-N n-(2-methyl-4-oxopentan-2-yl)prop-2-enamide Chemical compound CC(=O)CC(C)(C)NC(=O)C=C OMNKZBIFPJNNIO-UHFFFAOYSA-N 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 239000003381 stabilizer Substances 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 230000003075 superhydrophobic effect Effects 0.000 description 2
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 description 1
- OZAIFHULBGXAKX-UHFFFAOYSA-N 2-(2-cyanopropan-2-yldiazenyl)-2-methylpropanenitrile Chemical compound N#CC(C)(C)N=NC(C)(C)C#N OZAIFHULBGXAKX-UHFFFAOYSA-N 0.000 description 1
- OZAIFHULBGXAKX-VAWYXSNFSA-N AIBN Substances N#CC(C)(C)\N=N\C(C)(C)C#N OZAIFHULBGXAKX-VAWYXSNFSA-N 0.000 description 1
- IAZDPXIOMUYVGZ-WFGJKAKNSA-N Dimethyl sulfoxide Chemical compound [2H]C([2H])([2H])S(=O)C([2H])([2H])[2H] IAZDPXIOMUYVGZ-WFGJKAKNSA-N 0.000 description 1
- 244000020551 Helianthus annuus Species 0.000 description 1
- 235000003222 Helianthus annuus Nutrition 0.000 description 1
- 240000007594 Oryza sativa Species 0.000 description 1
- 235000007164 Oryza sativa Nutrition 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000001815 biotherapy Methods 0.000 description 1
- 229920000891 common polymer Polymers 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000012674 dispersion polymerization Methods 0.000 description 1
- 235000012489 doughnuts Nutrition 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000005265 energy consumption Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000010528 free radical solution polymerization reaction Methods 0.000 description 1
- 125000000524 functional group Chemical group 0.000 description 1
- 229920001002 functional polymer Polymers 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- VLKZOEOYAKHREP-UHFFFAOYSA-N hexane Substances CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 1
- 239000005457 ice water Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 239000012299 nitrogen atmosphere Substances 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 235000009566 rice Nutrition 0.000 description 1
- 238000004062 sedimentation Methods 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000001291 vacuum drying Methods 0.000 description 1
Classifications
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y40/00—Manufacture or treatment of nanostructures
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F2/00—Processes of polymerisation
- C08F2/46—Polymerisation initiated by wave energy or particle radiation
- C08F2/48—Polymerisation initiated by wave energy or particle radiation by ultraviolet or visible light
- C08F2/50—Polymerisation initiated by wave energy or particle radiation by ultraviolet or visible light with sensitising agents
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
- C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
- C08F220/10—Esters
- C08F220/12—Esters of monohydric alcohols or phenols
- C08F220/16—Esters of monohydric alcohols or phenols of phenols or of alcohols containing two or more carbon atoms
- C08F220/18—Esters of monohydric alcohols or phenols of phenols or of alcohols containing two or more carbon atoms with acrylic or methacrylic acids
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F293/00—Macromolecular compounds obtained by polymerisation on to a macromolecule having groups capable of inducing the formation of new polymer chains bound exclusively at one or both ends of the starting macromolecule
- C08F293/005—Macromolecular compounds obtained by polymerisation on to a macromolecule having groups capable of inducing the formation of new polymer chains bound exclusively at one or both ends of the starting macromolecule using free radical "living" or "controlled" polymerisation, e.g. using a complexing agent
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F2438/00—Living radical polymerisation
- C08F2438/03—Use of a di- or tri-thiocarbonylthio compound, e.g. di- or tri-thioester, di- or tri-thiocarbamate, or a xanthate as chain transfer agent, e.g . Reversible Addition Fragmentation chain Transfer [RAFT] or Macromolecular Design via Interchange of Xanthates [MADIX]
Abstract
The invention belongs to technical field of polymer materials, more particularly to viral shape nano material and its Actinochemical synthesis.The present invention provides a kind of Actinochemical synthesis of viral shape nano material, it include: uniformly to mix the second block monomer, multi-functional Macro RAFT agent and photoinitiator with selective solvent, dispersin polymerization is carried out in the case where causing light source and induces self assembly, obtains diblock copolymer nano material.Wherein the second block monomer includes acrylic ester monomer.The present invention also provides a kind of viral shaped polymer nano materials.The present invention provides a kind of viral shape nano material and its Actinochemical synthesis, can effectively solve the technical issues of existing visible light polymerization induction self assembly can not synthesize viral shape pattern polymer nano material.
Description
Technical field
The invention belongs to technical field of polymer materials, more particularly to viral shape nano material and its photochemical syntheses side
Method.
Background technique
The block copolymer nano material for having special appearance is always research hot topic, and polymer nano material definition is ruler
It at least needs to be less than 100nm there are dimension in very little, and different-shape (spherical, vesica, tubulose, baked donut shape, sunflower shape
Deng) polymer nano material biological therapy, drug conveying, catalysis, in terms of have huge potential application
Value.So the method for the block polymer nano material that development can prepare specific morphology is that one of macromolecule subject grinds
Study carefully emphasis.In recent years, polymerisation induced self assembly provides one newly to prepare the block polymer nano material of specific morphology
Thinking.And the pattern of the common block copolymer obtained by polymerisation induced self assembly only has ball and vesica, such case
The relatively restricted application field of copolymer.
It can be seen that light-initiated prepare the research hotspot that functional polymer is current macromolecule subject, there is efficiency of initiation
High and low energy consumption, required temperature be low, photocontrol property and the advantages that biological friendly, has prepared different morphologies at present
Block copolymer provides new method to prepare intelligent macromolecule.
In conclusion existing visible light polymerization induces the pattern of self assembly block copolymer and synthesizes disease
Malicious shape pattern becomes those skilled in the art's technical problem urgently to be resolved.
Summary of the invention
The present invention provides a kind of viral shape nano material and its Actinochemical synthesis, can effectively solve existing visible light
Cause the technical issues of polymerisation induced self assembly can not synthesize viral shape pattern polymer nano material.
The present invention is in view of the shortcomings of the prior art, main purpose is to provide a kind of viral shape easy to operate, that stability is high receives
The Actinochemical synthesis of rice material.This method carries out tune Jie using multi-functional RAFT reagent, to design the poly- of novel pattern
It closes object nano material and provides new mentality of designing.Viral shape nano material has the structure of more feelers on surface, on microcosmic
Particle surface modification can be effectively carried out, also can be applied to the preparation of super hydrophobic material.
Technical scheme is as follows: under nitrogen atmosphere by acrylic ester monomer, Diacetone Acrylamide it is more
Function Macro RAFT agent, photoinitiator and solvent mixing, carry out dispersion polymerization under the irradiation for causing light source, obtain
The diblock copolymer nano material of viral shape；Wherein, multi-functional Macro RAFT agent is as stabilizer and the molten segment of parent, into
Row RAFT light dispersin polymerization synthesizes stable viral shaped polymer nano material.
The beneficial effects of the present invention are: the present invention utilizes visible light-initiated RAFT dispersin polymerization, with poly- diacetone acrylamide
Amide (PDAAM) is the structure of multi-functional Macro RAFT agent, and acrylic ester monomer is polymerized monomer, is carried out in a solvent
Light initiation polymerization induction is self-assembly of viral shaped polymer nano material.Entire Macro RAFT agent be a stabilizer and
Solvophilic segment, Macro RAFT agent stability is high and has said solvophilic.After common polymer is formed, monomer is added
Also can not continue to increase chain extension, and the Macro RAFT agent that the present invention uses can cause again polymerization and form copolymer.Therefore, originally
The Actinochemical synthesis of invention has different morphologies, particularly has viral shape pattern, can be in catalysis, super-hydrophobic, nanometer
The fields such as reactor, biological medicine are with good application prospect.The light-initiated mode that the present invention takes, reaction rate is fast, only
It need to can reach within one hour 90% or more monomer conversion.Present invention can also apply to the monomer polymerization with functional group,
New thinking is provided for the functionalized polymer of design stability.
Detailed description of the invention
In order to more clearly explain the embodiment of the invention or the technical proposal in the existing technology, to embodiment or will show below
There is attached drawing needed in technical description to be briefly described, it should be apparent that, the accompanying drawings in the following description is only this
Some embodiments of invention without any creative labor, may be used also for those of ordinary skill in the art
To obtain other attached drawings according to these attached drawings.
Fig. 1 is transmission electron microscope (TEM) figure of the viral shaped polymer nano material of embodiment 2 provided by the invention preparation；
Fig. 2 is transmission electron microscope (SEM) figure of the viral shaped polymer nano material of embodiment 2 provided by the invention preparation；
Fig. 3 is transmission electron microscope (TEM) figure of the viral shaped polymer nano material of embodiment 3 provided by the invention preparation；
Fig. 4 is scanning electron microscope (SEM) figure of the viral shaped polymer nano material of embodiment 3 provided by the invention preparation；
Fig. 5 is transmission electron microscope (TEM) figure of the viral shaped polymer nano material of embodiment 4 provided by the invention preparation；
Fig. 6 is transmission electron microscope (SEM) figure of the viral shaped polymer nano material of embodiment 4 provided by the invention preparation；
Fig. 7 is transmission electron microscope (TEM) figure of the viral shaped polymer nano material of embodiment 5 provided by the invention preparation；
Fig. 8 is transmission electron microscope (SEM) figure of the viral shaped polymer nano material of embodiment 5 provided by the invention preparation；
Fig. 9 is nucleus magnetic hydrogen spectrum figure of the three functions small molecule RAFT reagent provided by the invention in deuterated dimethyl sulfoxide；
Figure 10 is nucleus magnetic hydrogen spectrum figure of the four functions small molecule RAFT reagent provided by the invention in deuterated chloroform.
Specific embodiment
The embodiment of the invention provides a kind of viral shape nano material and its Actinochemical synthesis, can effectively solve existing
The technical issues of visible light polymerization induction self assembly can not synthesize viral shape pattern polymer nano material.
Below in conjunction with the embodiment of the present invention, the technical scheme in the embodiment of the invention is clearly and completely described,
Obviously, the embodiment described is the embodiment of part of representative of the invention, rather than whole embodiments, this field are general
Other all embodiments obtained belong to protection of the invention to logical technical staff without making creative work
Range.
Wherein, the raw material of following instance is commercially available or self-control；
Embodiment 1
It is specific as follows present embodiment discloses the synthetic route of Macro RAFT agent:
Synthetic macromolecule RAFT reagent, structure is as shown in Equation 2, and structural formula 2 is specific the preparation method comprises the following steps: diacetone acrylamide acyl
Amine is obtained with multi-functional small molecules RAFT reagent by RAFT solution polymerization, wherein the knot of multi-functional small molecules RAFT reagent
Structure formula such as formula 1:
Formula 1；
Formula 2, n are the natural number of 10-100, and m is the natural number of 2-8；CORE is central node；
The present invention provides the specific synthetic route of Macro RAFT agent, and steps are as follows:
Into the round-bottomed flask of 100mL, addition Diacetone Acrylamide (20.0000g, 118.1893mmol), three functions are small
Molecule RAFT reagent (1.6812g, 1.8760mmol) or four function small molecule RAFT reagents (1.5533g, 1.4070mmol),
AIBN (0.1846g, 1.1256mmol), metaformaldehyde (1.0652g, 11.8189mmol) and dioxane (46g), stirring are equal
0.5mL sample is taken after even, seals reaction system after being passed through nitrogen 20min.Round-bottomed flask is put into and is heated to 70 DEG C of oil bath pan
Middle heating stirring contacts reaction system sufficiently with air and is put into ice water to carry out termination reaction after 2h, then takes 0.5mL sample
Product are characterized by nucleus magnetic hydrogen spectrum, determine conversion ratio using metaformaldehyde as internal standard to determine the practical segment degree of polymerization.It is used after reaction
N-hexane sedimentation, obtains yellow solid.Remaining solvent vacuum drying is removed, Macro RAFT agent is finally obtained；
Embodiment 2
The first Actinochemical synthesis of virus shaped polymer nano material provided by the invention, the specific steps are as follows:
It weighs isobornyl acrylate (IBOA, 1g, 4.8mmol), three function Macro RAFT agents (0.0716g,
0.0059mmol), photoinitiator diphenyl (2,4,6- trimethyl formamide) phosphine oxide (0.0021g, 0.0059mmol) is placed in
In 25mL round-bottomed flask, adding ethanol/water mixed solvent (1.9834g/0.35g, 85:15, w/w), to be stirred well to reagent complete
Fully dissolved.It keeps the nitrogen for continuing 20min to be passed through under the conditions of being protected from light, stops nitrogen and be passed through rear reaction system sealing.At 40 DEG C
Heat preservation 10min is protected from light under water-bath, with LED light (405nm, 0.45mW/cm2) illumination initiation is carried out, stop reaction after 1h30min.
Transmission electron microscope (TEM) figure of products therefrom and scanning electron microscope (SEM) figure are as shown shown in Figure 1 and Figure 2, are viral shape pattern.
Embodiment 3
It weighs isobornyl acrylate (IBOA, 1g, 4.8mmol), three function Macro RAFT agents (0.0708g,
0.0064mmol), photoinitiator diphenyl (2,4,6- trimethyl formamide) phosphine oxide (0.0021g, 0.0059mmol) is placed in
In 25mL round-bottomed flask, adding ethanol/water mixed solvent (1.9834g/0.35g, 85:15, w/w), to be stirred well to reagent complete
Fully dissolved.It keeps the nitrogen for continuing 20min to be passed through under the conditions of being protected from light, stops nitrogen and be passed through rear reaction system sealing.At 40 DEG C
Heat preservation 10min is protected from light under water-bath, with LED light (405nm, 0.45mW/cm2) illumination initiation is carried out, stop reaction after 1h30min.
Transmission electron microscope (TEM) figure and scanning electron microscope (SEM) figure of products therefrom are viral shape pattern as shown in attached drawing 3 and attached drawing 4.
Embodiment 4
It weighs isobornyl acrylate (IBOA, 1g, 4.8mmol), three function Macro RAFT agents (0.0466g,
0.0042mmol), photoinitiator diphenyl (2,4,6- trimethyl formamide) phosphine oxide (0.0021g, 0.0059mmol) is placed in
In 25mL round-bottomed flask, adding ethanol/water mixed solvent (1.9834g/0.35g, 85:15, w/w), to be stirred well to reagent complete
Fully dissolved.It keeps the nitrogen for continuing 20min to be passed through under the conditions of being protected from light, stops nitrogen and be passed through rear reaction system sealing.At 40 DEG C
Heat preservation 10min is protected from light under water-bath, with LED light (405nm, 0.45mW/cm2) illumination initiation is carried out, stop reaction after 1h30min.
Transmission electron microscope (TEM) figure and scanning electron microscope (SEM) figure of products therefrom are viral shape pattern as shown in attached drawing 5 and attached drawing 6.
Embodiment 5
It weighs isobornyl acrylate (IBOA, 1g, 4.8mmol), four function Macro RAFT agents (0.0676g,
0.0046mmol), photoinitiator diphenyl (2,4,6- trimethyl formamide) phosphine oxide (0.0021g, 0.0059mmol) is placed in
In 25mL round-bottomed flask, adding ethanol/water mixed solvent (1.9834g/0.35g, 85:15, w/w), to be stirred well to reagent complete
Fully dissolved.It keeps the nitrogen for continuing 20min to be passed through under the conditions of being protected from light, stops nitrogen and be passed through rear reaction system sealing.At 40 DEG C
Heat preservation 10min is protected from light under water-bath, with LED light (405nm, 0.45mW/cm2) illumination initiation is carried out, stop reaction after 1h30min.
Transmission electron microscope (TEM) figure and scanning electron microscope (SEM) figure of products therefrom are viral shape pattern as shown in attached drawing 7 and attached drawing 8.
Those skilled in the art is not under conditions of departing from the spirit and scope of the present invention that claims determine, also
Various modifications can be carried out to the above content.Therefore the scope of the present invention is not limited in above explanation, but by
The range of claims determines.
Claims (10)
1. a kind of Actinochemical synthesis of virus shape nano material characterized by comprising
Second block monomer, multi-functional Macro RAFT agent and photoinitiator are uniformly mixed with selective solvent, caused
Dispersin polymerization is carried out under light source and induces self assembly, obtains diblock copolymer nano material.Wherein the second block monomer includes third
Olefin(e) acid esters monomer.
2. the Actinochemical synthesis of virus shape nano material according to claim 1, which is characterized in that described second is embedding
Duan Danti is acrylic ester monomer.
3. the Actinochemical synthesis of virus shape nano material according to claim 1, which is characterized in that described multi-functional
The structural formula of RAFT reagent:
4. the Actinochemical synthesis of virus shape nano material according to claim 1, which is characterized in that described light-initiated
Agent include (2,4,6- trimethylbenzoyl) phenyl-phosphonic acid ethyl ester, diphenyl (2,4,6- trimethylbenzoyl) phosphine oxide,
One of bis- (2,4, the 6- trimethylbenzoyl) phosphine oxides of phenyl or (2,4,6- trimethylbenzoyl) phenyl-phosphonic acid sodium.
5. the Actinochemical synthesis of virus shape nano material according to claim 1, which is characterized in that the initiation light
The wavelength in source is 405-465nm.
6. the Actinochemical synthesis of virus shape nano material according to claim 1, which is characterized in that the initiation light
The light intensity in source is 0.3-50mW/cm2。
7. the Actinochemical synthesis of virus shape nano material according to claim 1, which is characterized in that the polymerization is single
It is 10%-30% that body, which accounts for system quality ratio,.
8. the Actinochemical synthesis of virus shape nano material according to claim 1, which is characterized in that the polymerization is single
The mass ratio of the material value of body and Macro RAFT agent is (50-400): 1.
9. the Actinochemical synthesis of virus shape nano material according to claim 1, which is characterized in that the macromolecular
The mass ratio of the material value of RAFT reagent and the photoinitiator is (1-5): 1.
10. a kind of virus shaped polymer nano material, which is characterized in that the viral shape as described in claim 1 to 9 any one
The Actinochemical synthesis of polymer nano material is prepared.
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| CN201910683797.2A CN110305272A (en) | 2019-07-26 | 2019-07-26 | A kind of virus shape nano material and its Actinochemical synthesis |
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| CN201910683797.2A CN110305272A (en) | 2019-07-26 | 2019-07-26 | A kind of virus shape nano material and its Actinochemical synthesis |
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Citations (2)
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| CN104220471A (en) * | 2012-02-03 | 2014-12-17 | 帝斯曼知识产权资产管理有限公司 | Polymeric beads, process and composition |
| CN106279469A (en) * | 2016-08-29 | 2017-01-04 | 中山大学 | A kind of quick method preparing clean polymer microballoon |
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| CN104220471A (en) * | 2012-02-03 | 2014-12-17 | 帝斯曼知识产权资产管理有限公司 | Polymeric beads, process and composition |
| CN106279469A (en) * | 2016-08-29 | 2017-01-04 | 中山大学 | A kind of quick method preparing clean polymer microballoon |
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