CN110301968A - A kind of bone and cartilage fixator and its application method - Google Patents
A kind of bone and cartilage fixator and its application method Download PDFInfo
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- CN110301968A CN110301968A CN201910700711.2A CN201910700711A CN110301968A CN 110301968 A CN110301968 A CN 110301968A CN 201910700711 A CN201910700711 A CN 201910700711A CN 110301968 A CN110301968 A CN 110301968A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
- A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
- A61B17/68—Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
- A61B17/683—Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin comprising bone transfixation elements, e.g. bolt with a distal cooperating element such as a nut
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
- A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
- A61B17/68—Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
- A61B17/686—Plugs, i.e. elements forming interface between bone hole and implant or fastener, e.g. screw
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
- A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
- A61B17/68—Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
- A61B17/84—Fasteners therefor or fasteners being internal fixation devices
- A61B17/86—Pins or screws or threaded wires; nuts therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
- A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
- A61B17/68—Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
- A61B17/84—Fasteners therefor or fasteners being internal fixation devices
- A61B17/86—Pins or screws or threaded wires; nuts therefor
- A61B17/8605—Heads, i.e. proximal ends projecting from bone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
- A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
- A61B17/68—Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
- A61B17/84—Fasteners therefor or fasteners being internal fixation devices
- A61B17/86—Pins or screws or threaded wires; nuts therefor
- A61B17/866—Material or manufacture
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/30721—Accessories
- A61F2/30749—Fixation appliances for connecting prostheses to the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/30756—Cartilage endoprostheses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/46—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor
- A61F2/4601—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor for introducing bone substitute, for implanting bone graft implants or for compacting them in the bone cavity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00831—Material properties
- A61B2017/00933—Material properties bone or bone-like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/30756—Cartilage endoprostheses
- A61F2002/30762—Means for culturing cartilage
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- Health & Medical Sciences (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
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- Heart & Thoracic Surgery (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Medical Informatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Transplantation (AREA)
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- Oral & Maxillofacial Surgery (AREA)
- Vascular Medicine (AREA)
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- Physical Education & Sports Medicine (AREA)
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Abstract
The invention discloses a kind of bones and cartilage fixator and its application method, bone and cartilage fixator are embedded into receptor bone bed, fixator is with the molding bracket of absorbable medical high molecular material 3D printing, bracket is made of the cylinder on top and the cone of lower part, and fixator connects and fixes the donor bone donor bone of organizational project culture with cartilage；Bone provided by the invention and cartilage fixator and its application method, organizational project donor can be securely fixed on receptor bone bed, fixation procedure will not cause to wear to cartilage around, and fixation procedure is extremely simple；Donor is in close contact always with receptor bone bed, provides stable healing environment；After fixator fixes donor bone donor bone and cartilage, final foreign is stored in vivo, is not in complication.
Description
Technical field
The present invention relates to a kind of bones and cartilage fixator and its application method, belong to technical field of medical equipment.
Background technique
Currently, because cartilage needs to do skin grafing and mending, existing when wound or abrasion lead to Cartilage defects or lose function
There are two types of cartilage transplantation modes for technology, are Cartilage transplantation and the transplanting of organizational project cultured cartilage respectively；Cartilage transplantation
Do mosaic transplanting with the cartilage in non-weight bearing area, the transplanting mode there are the shortcomings that first is that small area defect can only be handled, second is that
Cartilage donor site is limited, and now with the development of technology, organizational project cultured cartilage has a extensive future, by autogenous cell in vitro culture,
Close to after mature, cartilage is returned and plants defect point, large defect and the insufficient defect of donor can be repaired.
Donor cartilage generally has the following two kinds in the fixed form of receptor bone bed in the prior art:
It is fixed first is that making a small amount of suture in donor cartilage surrounding with absorbable thread；The shortcomings that this sample loading mode is operating difficulties, is held very much
It easily needs sutured portion to tear two sides, and is unfavorable for the integral fusion of both donor cartilage and receptor bone bed, lead to donor
The time that cartilage needs to restore biomechanical property is longer；Suture can cause to wear before being absorbed to cartilage around；
Second is that first piercing one piece of band line holdfast in receptor bone bed, suture then is done to donor cartilage with the line of tail portion and is fixed, in this way
The shortcomings that mode is that sutured portion is easy to tear and operating difficulties, after furthermore holdfast pierces human body, always as the allosome of host
In the presence of being easily deformed, loosen, furthermore there is also complication.
In summary, how donor cartilage is effectively fixed in this problem there is no highly desirable solution in the prior art
Certainly mode, this technical problem annoying always those skilled in the art, therefore, find a kind of new effective bone and cartilage
Fixator is come to solve deficiency in the prior art be urgent and necessary.
Summary of the invention
The technical problem to be solved by the present invention is to against the above deficiency, provide a kind of bone and cartilage fixator and its user
Donor bone donor bone and cartilage can be securely fixed on receptor bone bed by method, and fixation procedure will not cause to wear to cartilage around, Gu
It is extremely simple to determine process；Donor is in close contact always with receptor bone bed, provides stable healing environment, is shortened donor and is restored biology
The time of mechanical property；After fixator fixes donor, final foreign is stored in vivo, is not in complication；Donor and solid
After determining device implantation human body for a period of time, slowly combine together with receptor bone bed for knowing from experience.
In order to solve the above technical problems, the invention adopts the following technical scheme:
A kind of bone and cartilage fixator, including the fixator being embedded into receptor bone bed, fixator is with absorbable medical high score
The sub- molding bracket of material 3D printing, bracket are made of the cylinder on top and the cone of lower part；Fixator is by organizational project culture
Donor connected and fixed.
Further, the donor is that induction bone is loaded into the molding bracket of absorbable medical high molecular material 3D printing
With the host material of regenerating bone or cartilage, and host material is generated with appropriate method and is suitble to the micropore that grows into of cell.
Further, the cylinder is cylindrical, and inside is equipped with cylindrical cavity, cavity top opening, opening setting
There is an annular projection；The barrel of the cylinder is equipped with several uniformly distributed holes.
Further, the cavity bottom of the cylinder is blocked, and cavity bottom is equipped with the groove cooperated with screwdriver.
Further, the surface of the centerline collineation of the cone and cylinder, cone is equipped with external screw thread.
Further, the donor includes native donor, and fixed part is additionally provided on native donor, and fixed part is multi-clove type card
Joint structure, fixed part are equipped with an annular recess, and the annular recess is mutually clamped with annular projection.
Further, the quantity of the fixed part is more than or equal to 1.
Further, the fixator is mounted in the receptor drilling of receptor bone bed, and receptor drilling is stepped hole.
A kind of application method of bone and cartilage fixator, comprising the following steps:
Step 1: the dimension information of donor is obtained according to patient's imaging data, is beaten using absorbable medical high molecular material 3D
The bracket for printing off donor is loaded into the host material of induction regenerating bone or cartilage into bracket；Host material is generated by suitable method
It is suitable for the micropore of Bone Ingrowth；It takes patient's bone marrow stroma stem cell to be loaded into Medium Culture and carries out the culture of stem cell chondrocyte induction；(1) only
Cultured cartilage donor: being loaded into stem cell in donor, to cartilage direction induction culture 8-9 weeks, is then implanted into human body；(2) it only trains
It supports cancellous bone donor: being loaded into stem cell in donor, it is abundant in human body blood supply after implantation to cartilage direction induction culture 3 weeks
In environment, donor turns to the growth of osteocyte direction；(3) complex of cultured cartilage and bone: stem cell is carried out in cartilage phase
Chondrocyte induction culture 6 weeks, it is then loaded into stem cell in bone photo and carries out chondrocyte induction culture 3 weeks, while continuing in cartilage phase same
Step culture, then implants, and the cartilage cell in cartilage phase is mature on the whole, and continues to grow toward cartilage direction, soft in bone photo
Osteocyte in vivo under the conditions of can switch to bone cell growth, be finally grown to chondro-osseous complex；
Step 2: going out the bracket of fixator using absorbable medical high molecular material 3D printing, and induction cartilage is loaded into bracket
Regenerated host material；Generating host material by suitable method is suitable for the micropore of Bone Ingrowth, spare；
Step 3: a receptor for fixing holder is processed on receptor bone bed using drill bit and is drilled；
Step 4: when implantation by screwdriver screw groove by fixator be screwed into receptor drilling in, until fixator upper surface with
Receptor bone bed flush；
Step 5: cultured donor is connected and fixed with fixator；
Step 6: after donor and fixator are implanted into human body for a period of time, for cognition combining together with receptor bone bed slowly.
After the invention adopts the above technical scheme, compared with prior art, have the advantage that
1. the present invention provides a kind of bone and cartilage fixator and its application method, the fixator and donor of built-in type are solid by clamping
It is fixed, donor bone donor bone and cartilage can be securely fixed on receptor bone bed, entire fixation procedure will not cause to grind to cartilage around
Damage, fixation procedure are extremely simple；
2. donor is in close contact always with receptor bone bed, stable healing environment is provided, shortens donor and restores biomechanical property
Time；
3. fixator and donor are respectively adopted absorbable medical high molecular material 3D printing molding and are finally no different after donor is fixed
Object is stored in vivo, is not in complication；
4. slowly combining together with receptor bone bed after donor and fixator are implanted into human body for a period of time for knowing from experience.
The present invention is described in detail with reference to the accompanying drawings and examples.
Detailed description of the invention
Fig. 1 is the structural schematic diagram of fixator in the present invention；
Fig. 2 is the structure sectional view of Fig. 1；
Fig. 3 is the structural schematic diagram of donor in the present invention；
Fig. 4 is the structural front view of Fig. 3；
Fig. 5 is the scheme of installation of fixator in the present invention；
In figure,
1- fixator, 101- cylinder, 102- cone, 103- external screw thread, 104- cavity, 105- annular projection, 106- groove, 2- are supplied
Body, 201- native donor, 202- fixed part, 203- annular recess, 3- receptor bone bed, 301- receptor drill, cartilage around 4-.
Specific embodiment
For a clearer understanding of the technical characteristics, objects and effects of the present invention, this hair of Detailed description of the invention is now compareed
Bright specific embodiment.
A kind of bone of embodiment 1 and cartilage fixator
As shown in Figure 1, Figure 2, Fig. 3, Fig. 4 and Fig. 5 jointly shown in, the present invention provides a kind of bone and cartilage fixator, including fixator 1,
Fixator 1 is to use the molding bracket of absorbable medical high molecular material 3D printing, and bracket is by the cylinder 101 on top and the cone of lower part
Body 102 forms；Fixator 1 is for connecting and fixing the donor 2 of tissue cultures.
The cylinder 101 is cylindrical, and inside is equipped with cylindrical cavity 104,104 top opening of cavity, opening setting
There is an annular projection 105；101 barrel of cylinder is equipped with several uniformly distributed holes；104 bottom of cavity is sealed
It is stifled；104 bottom of cavity is equipped with groove 106, and groove 106 is line-styled, " ten " font or " rice " font, and groove 106 is arranged
Purpose, which is to cooperate with screwdriver, screws fixator 1；The bigger diameter end of the cone 102 is fixedly connected with the closure end of cylinder 101,
The centerline collineation of cone 102 and cylinder 101；The surface of the cone 102 is equipped with the external screw thread 103 for being used for fixed function,
Cone 102 is fixed in receptor bone bed 3 for piercing.
The fixator 1 is mounted in the receptor drilling 301 of receptor bone bed 3, and the receptor drilling 301 drills for receptor
301 be stepped hole, is made of the large diameter hole and diameter holes of centerline collineation, and large diameter hole is located at the top of diameter holes；
The diameter of 301 large diameter holes of the receptor drilling is equal to the outer diameter of cylinder 101, and the height of large diameter hole is equal to the height of cylinder 101
Degree, the receptor drill 301 diameter holes for fixing cone 102.
The fixator 1 is used to for donor 2 being fixed on the defect point of bone or cartilage；The donor 2 be bone, cartilage either
The complex of bone and cartilage；The donor 2 is that induction is loaded into the molding bracket of absorbable medical high molecular material 3D printing
The host material of bone and regenerating bone or cartilage, and so that host material is generated the micropore for being suitble to cell to grow into appropriate method；Donor 2 includes
The shape of native donor 201, native donor 201 is obtained according to patient's imaging data, is additionally provided with fixed part on native donor 201
202, fixed part 202 is that multi-clove type is clamped header structure, and fixed part 202 is equipped with an annular recess 203, the annular recess
203 are clamped with 105 phase of annular projection；The quantity of the fixed part 202 is more than or equal to 1, the particular number of fixed part 202 according to
Area at bone or cartilage defect is chosen.
The application method of embodiment 2 a kind of bone and cartilage fixator
The present invention provides the application method of a kind of bone and cartilage fixator, comprising the following steps:
Step 1: the dimension information of donor 2 is obtained according to patient's imaging data, is beaten using absorbable medical high molecular material 3D
The bracket for printing off donor 2 is loaded into the host material of induction regenerating bone or cartilage into bracket；Host material is generated by suitable method
It is suitable for the micropore of Bone Ingrowth；It takes patient's bone marrow stroma stem cell to be loaded into Medium Culture and carries out the culture of stem cell chondrocyte induction；(1) only
Cultured cartilage donor: being loaded into stem cell in donor 2, to cartilage direction induction culture 8-9 weeks, is then implanted into human body；(2) only
Culture cancellous bone donor: being loaded into stem cell in donor 2, rich in human body blood supply after implantation to cartilage direction induction culture 3 weeks
In rich environment, donor turns to the growth of osteocyte direction；(3) complex of cultured cartilage and bone: to stem cell in cartilage phase
Carry out chondrocyte induction culture 6 weeks, be then loaded into stem cell in bone photo and carry out chondrocyte induction culture 3 weeks, at the same cartilage phase it is interior after
Continuous synchronous culture, then implants, and the cartilage cell in cartilage phase is mature on the whole, and continues to grow toward cartilage direction, in bone photo
Cartilage cell in vivo under the conditions of can switch to bone cell growth, be finally grown to chondro-osseous complex；
Step 2: going out the bracket of fixator 1 using absorbable medical high molecular material 3D printing, and induction cartilage is loaded into bracket
Regenerated host material；Generating host material by suitable method is suitable for the micropore of Bone Ingrowth, spare；
Step 3: the receptor drilling 301 for fixing holder 1 is processed on receptor bone bed 3 using drill bit；
Step 4: screwing groove 106 by screwdriver when implantation and fixator 1 be screwed into receptor drilling 301, until fixator 1
Upper surface and 3 flush of receptor bone bed；
Step 5: cultured donor 2 is connected and fixed with fixator 1；
Step 6: after donor 2 and fixator 1 are implanted into human body for a period of time, it is one that donor 2, which can slowly melt with receptor bone bed 3,
Body.
The above is the citing of best mode for carrying out the invention, wherein the part that do not address in detail is that this field is common
The common knowledge of technical staff.Protection scope of the present invention is based on the contents of the claims, any based on technology of the invention
The equivalent transformation of enlightenment and progress, also within protection scope of the present invention.
Claims (9)
1. a kind of bone and cartilage fixator, it is characterised in that: including the fixator (1) being embedded into receptor bone bed (3), fixator
(1) be with the molding bracket of absorbable medical high molecular material 3D printing, bracket by top cylinder (101) and lower part cone
(102) it forms；Fixator (1) connects and fixes the donor (2) of organizational project culture.
2. a kind of bone as described in claim 1 and cartilage fixator, it is characterised in that: the donor (2) is in absorbable doctor
The host material of bone and regenerating bone or cartilage is induced with loading in the molding bracket of high molecular material 3D printing, and makes base with appropriate method
Material generates the micropore for being suitble to cell to grow into.
3. a kind of bone as described in claim 1 and cartilage fixator, it is characterised in that: the cylinder (101) is cylindrical, interior
Portion is equipped with cylindrical cavity (104), cavity (104) top opening, and opening is provided with an annular projection (105)；The cylinder
The barrel of body (101) is equipped with several uniformly distributed holes.
4. a kind of bone as described in claim 1 and cartilage fixator, it is characterised in that: the cavity (104) of the cylinder (101)
Bottom is blocked, and cavity (104) bottom is equipped with the groove (106) cooperated with screwdriver.
5. a kind of bone as described in claim 1 and cartilage fixator, it is characterised in that: the cone (102) and cylinder (101)
Centerline collineation, the surface of cone (102) is equipped with external screw thread (103).
6. a kind of bone as described in claim 1 and cartilage fixator, it is characterised in that: the donor (2) includes native donor
(201), it is additionally provided with fixed part (202) on native donor (201), fixed part (202) is that multi-clove type is clamped header structure, fixed part
(202) it is equipped with an annular recess (203), the annular recess (203) is mutually clamped with annular projection (105).
7. a kind of bone as claimed in claim 6 and cartilage fixator, it is characterised in that: the quantity of the fixed part (202) is big
In equal to 1.
8. a kind of bone as described in claim 1 and cartilage fixator, it is characterised in that: the fixator (1) is mounted on receptor
In the receptor drilling (301) of bone bed (3), receptor drills (301) as stepped hole.
9. the application method of a kind of bone and cartilage fixator, it is characterised in that: the following steps are included:
Step 1: the dimension information of donor (2) is obtained according to patient's imaging data, using absorbable medical high molecular material 3D
The bracket for printing donor (2) is loaded into the host material of induction regenerating bone or cartilage into bracket；Make host material by suitable method
Generate the micropore of suitable Bone Ingrowth；It takes patient's bone marrow stroma stem cell to be loaded into Medium Culture and carries out the culture of stem cell chondrocyte induction；
(1) only cultured cartilage donor: stem cell is loaded into donor (2) and was then implanted into people to cartilage direction induction culture 8-9 weeks
Body；(2) it only cultivates cancellous bone donor: being loaded into stem cell in donor (2), to cartilage direction induction culture 3 weeks, after implantation,
In human body blood supply environment abundant, donor turns to the growth of osteocyte direction；(3) complex of cultured cartilage and bone: in cartilage phase
It is interior that stem cell is carried out chondrocyte induction culture 6 weeks, stem cell progress chondrocyte induction culture 3 weeks is then loaded into bone photo, simultaneously
Continue synchronous culture in cartilage phase, then implant, the cartilage cell in cartilage phase is mature on the whole, and continues raw toward cartilage direction
It is long, cartilage cell in bone photo in vivo under the conditions of can switch to bone cell growth, be finally grown to chondro-osseous complex；
Step 2: going out the bracket of fixator (1) using absorbable medical high molecular material 3D printing, and it is soft that induction is loaded into bracket
The host material of osteanagenesis；Generating host material by suitable method is suitable for the micropore of Bone Ingrowth, spare；
Step 3: a receptor for fixing holder (1) is processed on receptor bone bed (3) using drill bit and drills (301)；
Step 4: screwing groove (106) by screwdriver when implantation and fixator (1) be screwed into receptor drilling (301), until fixed
The upper surface of device (1) and receptor bone bed (3) flush；
Step 5: cultured donor (2) and fixator (1) are connected and fixed；
Step 6: by donor (2) and fixator (1) implantation human body for a period of time after, donor (2) can slowly with receptor bone bed
(3) it combines together.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910700711.2A CN110301968A (en) | 2019-07-31 | 2019-07-31 | A kind of bone and cartilage fixator and its application method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910700711.2A CN110301968A (en) | 2019-07-31 | 2019-07-31 | A kind of bone and cartilage fixator and its application method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN110301968A true CN110301968A (en) | 2019-10-08 |
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ID=68082602
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910700711.2A Withdrawn CN110301968A (en) | 2019-07-31 | 2019-07-31 | A kind of bone and cartilage fixator and its application method |
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| Country | Link |
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| CN (1) | CN110301968A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115192273A (en) * | 2022-09-19 | 2022-10-18 | 北京大学第三医院（北京大学第三临床医学院） | Personalized metal 3D printing osteochondral transplantation instrument and method |
-
2019
- 2019-07-31 CN CN201910700711.2A patent/CN110301968A/en not_active Withdrawn
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115192273A (en) * | 2022-09-19 | 2022-10-18 | 北京大学第三医院（北京大学第三临床医学院） | Personalized metal 3D printing osteochondral transplantation instrument and method |
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Application publication date: 20191008 |