CN110292365A - A kind of accurate blood flow control method based on external counterpulsation - Google Patents
A kind of accurate blood flow control method based on external counterpulsation Download PDFInfo
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- CN110292365A CN110292365A CN201910419351.9A CN201910419351A CN110292365A CN 110292365 A CN110292365 A CN 110292365A CN 201910419351 A CN201910419351 A CN 201910419351A CN 110292365 A CN110292365 A CN 110292365A
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/02028—Determining haemodynamic parameters not otherwise provided for, e.g. cardiac contractility or left ventricular ejection fraction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
- A61B5/316—Modalities, i.e. specific diagnostic methods
- A61B5/318—Heart-related electrical modalities, e.g. electrocardiography [ECG]
- A61B5/346—Analysis of electrocardiograms
- A61B5/349—Detecting specific parameters of the electrocardiograph cycle
- A61B5/352—Detecting R peaks, e.g. for synchronising diagnostic apparatus; Estimating R-R interval
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Abstract
The invention belongs to external counterpulsation technical field, especially a kind of accurate blood flow control method based on external counterpulsation, the method includes: that (1) obtains ECG waveform, non-invasive blood pressure waveform, blood oxygen SPO2 signal；(2) according to the blood vessel personalizing parameters of patient, corresponding personalized lumen of vessels model is established, outgoing blood phase average speed of blood stream Vs is calculated；(3) heart and blood flow distance L in place's to be guided are calculated according to patient's human parameters；(4) heart is calculated to start to penetrate the time T that blood reaches blood place need to be guided to blood；(5) ecg-r wave point is identified using no-delay heart real time algorithm, the T moment after recognizing R point starts to trigger counterpulsation, so that heart projects blood and counterpulsation blood is superimposed upon blood flow place to be guided；Control method provided by the invention can cooperate external counterpulsation technology to be precisely controlled uplink counterpulsation blood flow and downlink cardiac ejection blood flow point, to realize the purpose for increasing a certain specific diseased organ blood flow.
Description
Technical field
The invention belongs to external counterpulsation technical field, especially a kind of accurate blood flow control method based on external counterpulsation.
Background technique
External counterpulsation technology is a kind of in diastole extruding lower limb vascular, realizes that arterial blood reflux, increase are at different levels dynamic
The method of arteries and veins blood flow can mitigate and eliminate angina pectoris symptom by implementing external counterpulsation, improve the anoxic of body important organ
Ischemic state simultaneously can be used for prevention and treatment cardiovascular and cerebrovascular disease；In vitro in a kind of specific embodiment of counterpulsation, by
Pressurizing device is arranged in leg and hip point, pressurizes in diastole to leg and buttocks, the blood of limb artery is promoted to drive
Aorta is returned to, keeps diastolic pressure significantly raised, increases blood flow for heart, reduces cardiac afterload；It pressurizes in paradoxical expansion
Device explosive decompression, pressure releases promote aorta contract drops, mitigate cardiac ejection phase resistance, blood to greatest extent
Accelerate flow direction distal end, to reach counterpulsation effect.
Currently, external counterpulsation technology is only only completed extruding, so that lower extremity blood flow flows back, the diastole reflux blood is not studied
The influence to arteries at different levels is flowed, only actually learns that artery blood flows at different levels increase, and is unable to complete accurate blood flow guiding, realizes
Increase the function of a certain specific diseased organ blood flow.
Summary of the invention
The accurate blood flow control method based on external counterpulsation that the purpose of the present invention is to provide a kind of, control uplink blood flow with
The assemble jamming is precisely directed to secondary arterial branch by downlink blood flow point, realizes the specific a certain diseased organ blood flow of increase
Amount.
To achieve the goals above, the present invention is achieved by the following scheme:
A kind of accurate blood flow control method based on external counterpulsation, comprising the following steps:
(1) ECG waveform, non-invasive blood pressure waveform, blood oxygen SPO2 signal are obtained；
(2) according to the blood vessel personalizing parameters of patient, corresponding personalized lumen of vessels model is established, outgoing blood phase blood is calculated
Flow average speed Vs；
(3) heart and blood flow distance L in place's to be guided are calculated according to patient's human parameters；
(4) heart is calculated to start to penetrate the time T that blood reaches blood place need to be guided to blood；
(5) ecg-r wave point is identified using no-delay heart real time algorithm, the T moment after recognizing R point starts to trigger
Counterpulsation, so that heart projects blood and counterpulsation blood is superimposed upon blood flow place to be guided；
Wherein, the lumen of vessels model be use electro-hydraulic analogy method, by the frictional dissipation of blood flow, vascular compliance with
And blood flow the inertia equivalent resistance in circuit components, capacitor and inductance respectively；
The equivalent circuit that left heart blood circulation is listed according to the lumen of vessels model passes through the state equation of circuit and gives
The initial value for determining variable once finds out the solution of variable using the method for difference.
Compared with prior art, the present invention has following technical effect that
Control method provided by the invention establishes personalized model by the personalizing parameters of patient, can be with ligand outside
The assemble jamming is precisely directed to by counterpulsation technology to be precisely controlled uplink counterpulsation blood flow and downlink cardiac ejection blood flow point
Secondary arterial branch, to realize the purpose for increasing a certain specific diseased organ blood flow.
Detailed description of the invention
The logical schematic of Fig. 1 accurate blood flow control method provided by the invention；
Fig. 2 is the model schematic of artery and vein；
Fig. 3 is that valve moves flow resistance model schematic；
Fig. 4 is left painstaking effort fluid circulation equivalent circuit diagram；
Fig. 5 is that valve flow changes with time figure；
Fig. 6 is the ECG waveform/pulse waveform schematic diagram applied after external counterpulsation.
Specific embodiment
In order to be easy to understand the technical means, the creative features, the aims and the efficiencies achieved by the present invention, tie below
Specific attached drawing is closed, the present invention is furture elucidated.
The accurate blood flow control method based on external counterpulsation that the present invention provides a kind of, comprising the following steps:
(1) ECG waveform, non-invasive blood pressure waveform, blood oxygen SPO2 signal are obtained；
(2) according to the blood vessel personalizing parameters of patient, corresponding personalized lumen of vessels model is established, outgoing blood phase blood is calculated
Flow average speed Vs；
(3) heart and blood flow distance L in place's to be guided are calculated according to patient's human parameters；
(4) heart is calculated to start to penetrate the time T that blood reaches blood place need to be guided to blood；
(5) ecg-r wave point is identified using no-delay heart real time algorithm, the T moment after recognizing R point starts to trigger
Counterpulsation, so that heart projects blood and counterpulsation blood is superimposed upon blood flow place to be guided；
Wherein, the lumen of vessels model be use electro-hydraulic analogy method, by the frictional dissipation of blood flow, vascular compliance with
And blood flow the inertia equivalent resistance in circuit components, capacitor and inductance respectively；
The equivalent circuit that left heart blood circulation is listed according to the lumen of vessels model passes through the state equation of circuit and gives
The initial value for determining variable once finds out the solution of variable using the method for difference.
Specifically, heretofore described blood vessel personalizing parameters include that rotary inertia pressure gradient influences COEFFICIENT K p, blood
Stream influences coefficient Kb and valve open angle θ.When patient carries out counterpulsation treatment for the first time, using the above-mentioned of ultrasonic measurement patient
Then blood vessel personalizing parameters can record above-mentioned personalizing parameters to facilitate the treatment for carrying out counterpulsation next time.
In the present invention, in the modeling process of lumen of vessels model, human body body circulation and pulmonary circulation is divided into aorta/lung and moved
Arteries and veins, parteriole, arteriole, venule, veinlet and vena cave/pulmonary vein.Wherein aortic sinus, main artery are quite flexible
, it is therefore desirable to consider complete resistance, compliance and inductive effect (RLC combination)；In parteriole and capillary, vascular wall
Relative stiffness, flowing be it is stable, friction loss is leading factor, therefore local flow dynamics is by a pure resistance member
Part fully describes；Vein is usually to be used as a reservoir, is divided again with adapting to the blood volume of the transition period of different physiological conditions
Match, blood flow is relatively stable, therefore the inertia effect is often ignored, therefore its flow behavior is described with RC combination；Specifically such as Fig. 2 institute
Show.
The structure of heart is broadly divided into the chambers of the heart and valve, and the main function of the chambers of the heart is storage of blood and is shunk by its active
Characteristic blood is pumped out, therefore can be held with power transformation under normal conditions to simulate atrium and ventricle, but for simplified model,
Atrium and ventricle are simulated used here as a normal capacitor.The main function of valve is the one-way flow for controlling blood, needs to examine
Consider valve to the resistance and the inertia effect of blood, the model of valve variable flow resistance model, movement flow resistance model and controllable anti-sometimes
Volume motion flow resistance model is flowed, considers to use mechanical prosthetic valve on experiment in vitro platform, and for simplified model, here using movement
Flow resistance model, as shown in Figure 3.
According to above each model, the sanguimotor limitation of experiment in vitro platform is considered, only consider left heart blood circulation, Zuo Xin
Room-bicuspid valve-aorta petal-aorta ascendens valve-descending aorta and cerebral artery-vein-atrium sinistrum, equivalent circuit diagram such as Fig. 4 institute
Show.
By listing the state equation of circuit, and the initial value of given variable, the method that difference can be used once find out change
The solution of amount.
State equation is as follows:
Wherein X1It indicates left ventricular pressure (LVP)；X2It indicates left atrial pressure (LAP)；X3It indicates ascending aortic pressure (SAP)；X4Table
Show descending aorta pressure (SDP)；X5It indicates vein pressure (SVP)；X6Cerebral artery pressure (CPP)；X7Bicuspid valve flow (QM)；X8Bicuspid valve
Open angle (θ M)；X9Aorta petal flow (QA)；X10Aorta open angle (θ A)；X11Aorta ascendens flow (QSAP)；X12
It indicates descending aorta flow (QSDP)；X13It indicates cerebral artery flow (QCPP).
The setting of equation group initial value is as follows: X1=8.2mmHg；X2=7.6mmHg；X3=67mmHg；X4=80mmHg；X9=
52mL/s；X7=50mL/s；X8=X10=85 °；X5=X6=X11=X12=X13=0.The initial value of state equation is only to Fig. 5's
Initial point has an impact, and ignores to integrating effect.
The model influences COEFFICIENT K p and influence of blood flow coefficient Kb by adjusting the unit turn inertia pressure gradient of valve, with
And valve open angle θ and heart rate Hr characterizes the heart state of different patients.
In a specific embodiment of the invention:
It such as a patient, is measured by transabdominal ultrasonography, bicuspid valve pressure gradient influences COEFFICIENT K pmi=3500, influence of blood flow system
Number Kbmi=300；Aorta petal pressure gradient influences COEFFICIENT K pao=350, influence of blood flow coefficient Kb ao=300；Heart Rate
For Hr=83bpm, in addition, being simplified model, bicuspid valve is identical with aorta open angle, θ min=9.905, θ max=
85.000.Finally solve aortic flow X9As shown in Figure 5.
By Tstart be bicuspid valve open at the time of, correspond to ecg wave form in the R wave moment, be that bicuspid valve flow is just opened
It is the 0.1s moment in Fig. 5 at the time of beginning to be greater than 0, at the time of Tc is mitral valve closure, Tstart to Tc is ejection time, mould
It is the 1/3 of cardiac electrical cycle in type, is 1/3 × 60/Hr=20/Hr=0.24
It is integrated to blood phase flow is penetrated:
Topen is the time Topen=1/3*60/Hr=0.24s that aorta petal is opened
Blood phase average flow rate Vs=Q/Topen/SR must be emitted；Wherein SR is vessel area,
Normal adult's aorta ascendens internal diameter 32-34mm；
SRmax=3.14 × 32mm/2 × 32mm/2=8.04cm2
SRmin=3.14 × 34mm/2 × 34mm/2=9.07cm2；Average SR=8.5cm2
Vs=33.47 (cm/s)
More specifically, if blood place to be guided is kidney；Measure the patient height be 170cm, heart and kidney away from
From for L, which is about the 1/10 of height, i.e. 17cm.Aorta average speed is Vs, 33.47cm/s, so from aorta
Starting to penetrate blood to flow to the time required for kidney to blood is Tkidney=L/V, about 508ms.
Divide water if it is desired that obtaining the main wave of cardiac ejection and going out to be superimposed generation in liver or kidney with the counterpulsation wave of external counterpulsation
Ridge illustrates the main wave of cardiac ejection as long as counterpulsation wave is made to start (i.e. R wave) T (about 508ms) at the moment in left ventricular ejection
It is superimposed at T moment (about 508ms) with the counterpulsation wave of external counterpulsation, and cardiac ejection blood flow just reaches at kidney at this time.
Basic principles and main features and the features of the present invention of the invention have been shown and described above.The technology of the industry
Personnel are it should be appreciated that the present invention is not limited to the above embodiments, and the above embodiments and description only describe this
The principle of invention, without departing from the spirit and scope of the present invention, various changes and improvements may be made to the invention, these changes
Change and improvement is both fallen in the range of claimed invention.The scope of protection of present invention is by appended claims
And its equivalent thereof.
Claims (2)
1. a kind of accurate blood flow control method based on external counterpulsation, which comprises the following steps:
(1) ECG waveform, non-invasive blood pressure waveform, blood oxygen SPO2 signal are obtained；
(2) according to the blood vessel personalizing parameters of patient, corresponding personalized lumen of vessels model is established, it is flat to calculate outgoing blood phase blood flow
Equal speed Vs；
(3) heart and blood flow distance L in place's to be guided are calculated according to patient's human parameters；
(4) heart is calculated to start to penetrate the time T that blood reaches blood place need to be guided to blood；
(5) ecg-r wave point is identified using no-delay heart real time algorithm, it is anti-that the T moment after recognizing R point starts triggering
It fights, so that heart projects blood and counterpulsation blood is superimposed upon blood flow place to be guided；
Wherein, the lumen of vessels model is to use electro-hydraulic analogy method, by the frictional dissipation of blood flow, vascular compliance and blood
Flow the inertia equivalent resistance in circuit components, capacitor and inductance respectively；
The equivalent circuit that left heart blood circulation is listed according to the lumen of vessels model, state equation and given change by circuit
The initial value of amount once finds out the solution of variable using the method for difference.
2. the accurate blood flow control method according to claim 1 based on external counterpulsation, which is characterized in that the blood vessel
Personalizing parameters include that rotary inertia pressure gradient influences COEFFICIENT K p, influence of blood flow coefficient Kb and valve open angle θ.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112932423A (en) * | 2021-01-25 | 2021-06-11 | 中山大学附属第八医院（深圳福田） | Cardiovascular and cerebrovascular disease prediction method, system and equipment based on external counterpulsation intervention |
| CN113018135A (en) * | 2021-02-24 | 2021-06-25 | 山东交通学院 | External counterpulsation cooperative control system and method |
| CN117838510A (en) * | 2024-03-08 | 2024-04-09 | 深圳市艾利特医疗科技有限公司 | External counterpulsation device and external counterpulsation signal control method |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030009119A1 (en) * | 2001-03-23 | 2003-01-09 | Kamm Roger D. | Method and apparatus for stimulating angiogenesis and wound healing by use of external compression |
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- 2019-05-20 CN CN201910419351.9A patent/CN110292365A/en active Pending
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030009119A1 (en) * | 2001-03-23 | 2003-01-09 | Kamm Roger D. | Method and apparatus for stimulating angiogenesis and wound healing by use of external compression |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112932423A (en) * | 2021-01-25 | 2021-06-11 | 中山大学附属第八医院（深圳福田） | Cardiovascular and cerebrovascular disease prediction method, system and equipment based on external counterpulsation intervention |
| CN112932423B (en) * | 2021-01-25 | 2024-05-28 | 中山大学附属第八医院（深圳福田） | Method, system and equipment for predicting cardiovascular and cerebrovascular diseases based on external counterpulsation intervention |
| CN113018135A (en) * | 2021-02-24 | 2021-06-25 | 山东交通学院 | External counterpulsation cooperative control system and method |
| CN113018135B (en) * | 2021-02-24 | 2023-01-31 | 山东交通学院 | External counterpulsation cooperative control system and method |
| CN117838510A (en) * | 2024-03-08 | 2024-04-09 | 深圳市艾利特医疗科技有限公司 | External counterpulsation device and external counterpulsation signal control method |
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