CN110292352A - A kind of power transformation sense wireless type intraocular pressure monitoring sensor based on microfibre pipe - Google Patents
A kind of power transformation sense wireless type intraocular pressure monitoring sensor based on microfibre pipe Download PDFInfo
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- CN110292352A CN110292352A CN201910629641.6A CN201910629641A CN110292352A CN 110292352 A CN110292352 A CN 110292352A CN 201910629641 A CN201910629641 A CN 201910629641A CN 110292352 A CN110292352 A CN 110292352A
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- microfibre
- intraocular pressure
- pipeline
- sensor
- pipe
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
- A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
- A61B3/16—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for measuring intraocular pressure, e.g. tonometers
Abstract
The invention belongs to the field of medical instrument technology, disclose a kind of power transformation sense wireless type intraocular pressure monitoring sensor based on microfibre pipe, including contact lens (1), microfibre pipeline (2), liquid metal (3) and patch capacitor (4), wherein: microfibre pipeline and liquid metal are integrally formed inductance component, couple to form LC resonance formula sensor with patch capacitor；The inductance value of inductance component is by Effect of Intraocular Pressure, so that equally the real-time sensing monitoring to intraocular pressure can be realized by reading the variation of resonance frequency by Effect of Intraocular Pressure in the resonance frequency of LC resonance formula sensor.The characteristics of present invention is by combining intraocular pressure to monitor clinical application itself, realize that intraocular pressure is monitored and is designed to its specific structure and its specific set-up mode using the LC sensor that the microfibre pipe and capacitor for being passed through liquid metal are constituted, monitoring intraocular pressure can be realized in the change by reading LC sensor resonant frequency.
Description
Technical field
The invention belongs to the field of medical instrument technology, wireless more particularly, to a kind of power transformation sense based on microfibre pipe
Formula intraocular pressure monitors sensor.
Background technique
Glaucoma is No. 1 in the world irreversibility diseases causing blindness.Medical practice finds out that intraocular pressure increases and non-glaucomatous damage
Important role, and its table are equally played the part of in the unique risk factor of evil, pathologic intraocular pressure fluctuation in glaucoma occurrence and development
Now more hide.Therefore concern 24 hours fluctuation situation ratios of intraocular pressure are solely focused on intraocular pressure absolute value and increase even more important, this sight
Point has become the common recognition of whole world glaucoma expert.
The current clinical method for being used to monitor the fluctuation of 24 hours intraocular pressures is generallyd use at interval of measurement in 2 hours once, but this
Kind replaces being not enough within 24 hours reflect the overall picture that intraocular pressure fluctuates comprehensively in a manner of fluctuation overall process by 12 monitoring points；In addition, surveying
Amount generally requires seat progress, therefore can not learn the intraocular pressure truth under patient's nature animation, such as sleep, movement
Deng.Correspondingly, it is necessary to which 24 hours intraocular pressure monitoring technology are more studied.
24 hours intraocular pressures monitoring fluctuation monitoring technology in the prior art includes intrusive " LC- resonant transducer ", benefit
With the strain chip non-invasive sensors of Wheatstone bridge principle and the change inductance type " LC- resonant transducer " of non-intrusion type
Deng.Although intrusive mood measurement may be implemented directly to measure but implant surgery will cause expendable injury to eyeball, for
The monitoring of the intraocular pressure of ordinary people or suspect glaucoma patient is then not suitable for.Strain chip non-invasive sensors (referring to
“Wireless contact lens sensor for intraocular pressure monitoring:assessment
On enucleated pig eyes. ", Matteo Leonardi, Arnaud Bertsch, Andr é Mermoud.) it is based on answering
The principle for becoming piece, which is realized 24 hours fluctuated to intraocular pressure, to be monitored, and the target of monitoring in 24 hours is realized.But further study table
Bright, 1) comfort worn is poor；2) sensitivity and detection accuracy of sensor are inadequate；3) jitter exported, leads to it
Clinical expansion is restricted.24 hours intraocular pressure monitors of change inductance type that Hong Kong is developed are (referring to " Soft wearable
contact lens sensor for continuous intraocular pressure monitoring”,Guo-Zhen
Chen,Ion-Seng Chan,Leo K.K.Leung,David C.C.Lam.The Hong Kong University of
Science and Technology, Hong Kong.) 24 hours of intraocular pressure are measured based on the principle realization that inductance changes, but
Since it uses metal copper foil as inductance coil material, due to the mechanics scale ratio contact lens material and human eye material of copper foil
Expect much bigger, lead to it: 1) it is very difficult to be coupled into contact lenses for sension unit；2) since the elasticity modulus of copper foil is very big, by
The diameter change of inductance coil caused by intraocular pressure fluctuates is very small, and inductance variation is small, causes transducer sensitivity extremely low；3) hard
Copper foil causes sensor wearing comfort excessively poor, will affect and wears region cornea with deforming caused by intraocular variation.
Summary of the invention
Aiming at the above defects or improvement requirements of the prior art, the purpose of the present invention is to provide one kind to be based on microfibre pipe
Power transformation sense wireless type intraocular pressure monitor sensor, the characteristics of by combining intraocular pressure to monitor clinical application itself, using being passed through liquid
The LC sensor that the microfibre pipe and capacitor of metal are constituted is to realize intraocular pressure monitoring and to its specific structure and its specific setting side
Formula is designed, and when the intraocular pressure of eyeball changes, the inductance coil that microfibre pipe is constituted can be also deformed, so as to cause
The change of inductance value causes the change of LC sensor resonant frequency, and then can pass through external wireless reading circuit or network
The change of the reading resonance frequency such as analyzer or impedance analyzer；Since intraocular pressure can cause the pole of microfibre pipe inductance coil
It is big to change the high precision real-time measurement, it can be achieved that intraocular pressure, while intraocular pressure monitoring sensor being made to have high sensitivity, dynamic model
Enclose the advantages that big, stability is good, using comfortable and small in volume.
To achieve the above object, it is proposed, according to the invention, provide a kind of power transformation sense wireless type intraocular pressure prison based on microfibre pipe
Survey sensor, which is characterized in that including contact lens (1), microfibre pipeline (2), be sealed in the microfibre pipeline (2)
Liquid metal (3), and be integrally coupled by copper wire (5) and the microfibre pipeline (2) and its interior liquid metal (3)
Patch capacitor (4), in which:
The contact lens (1) is integrally in spherical crown shape, and for when wearing and the eyeball shape of patient matches
It is bonded；
The microfibre pipeline (2) is embedded in inside the mirror plate layers of the contact lens (1), the microfibre pipeline (2)
Around the distribution spiral yarn shaped in the shape of a spiral of the center of the contact lens (1), the head and the tail both ends of microfibre pipeline (2) entirety
The copper wire (5) for being 50~100 microns by diameter is drawn from the contact lens (1), and with the patch capacitor (4) phase
Coupling；
The microfibre pipeline (2) is at least the spiral yarn shaped of a full circle, the microfibre pipeline (2) and its interior described
Liquid metal is integrally formed inductance component, couples with the patch capacitor (4) and constitutes LC resonance circuit, forms LC resonance formula sensing
Device；The inductance value of the inductance component is by Effect of Intraocular Pressure, so that the resonance frequency of the LC resonance formula sensor is equally by Effect of Intraocular Pressure,
By reading the variation of resonance frequency, the real-time sensing monitoring to intraocular pressure can be realized.
As present invention further optimization, the internal diameter of the microfibre pipeline (2) is less than or equal to 0.2mm, and preferably 0.1
~0.2mm；Outer diameter is 0.2~0.3mm.
As present invention further optimization, the microfibre pipeline (2) is in around the center of the contact lens (1)
The helical the distribution of line shape of 2~4 circles, and the spiral yarn shaped minimum diameter is greater than 5mm, the inductance of the inductance component
Value meets 90nH~0.21mH.
As present invention further optimization, the patch capacitor (4) is patch capacitor or 01005 encapsulation of 0201 encapsulation
Patch capacitor, and capacitance value range meet 6.0~8.5pF.
As present invention further optimization, the resonance frequency of the LC resonance formula sensor meets 50~300MHz.
As present invention further optimization, the specification of the contact lens (1) be set to diameter 12mm~
18mm, thickness is less than 0.4mm, and its material is preferably PDMS.
As present invention further optimization, the microfibre pipeline (2) uses silastic material, the liquid metal
(3) it is sealed in the microfibre pipeline (2) also by silastic material.
As present invention further optimization, the liquid metal (3) is nontoxic, specially EGaIn or Galinstan.
Contemplated above technical scheme through the invention, compared with prior art, due in soft contact lens
Interior setting fento vasculation inductance component, particularly, microfibre pipe helical form is wound on inside the mirror plate layers of contact lens,
Be passed through liquid metal as inductance component (liquid metal can be room temperature liquid metal, such as nontoxic EGaIn or
Galinstan), forming spiral inductance, (the linear at least complete circle of the helical of microfibre pipe, i.e. central angle are at least
360 ° spiral yarn shaped), constitute LC resonance formula sensor with coupled capacitor, wherein patch capacitor be passed through the micro- of liquid metal
Fibre pipe is coupled by 50 microns of copper wire.When the intraocular pressure of eyeball changes, contact lens bending deformation, microfibre pipe
The inductance coil of composition can be also deformed, and so as to cause the change of inductance value, cause the change of LC sensor resonant frequency, be led to
The change that external wireless reading circuit or Network Analyzer or impedance analyzer etc. read resonance frequency is crossed, can be realized pair
24 hours continuous real-time monitorings of intraocular pressure.
Helically pitch of the laps is distributed in contact lense center to microfibre pipe, and circle number is 2-4 circles, and it is (big that minimum diameter is greater than 5mm
In the pupil diameter of people), do not hinder human eye to regard object.Especially, pass through the shape size and specific set-up mode to microfibre pipe
It is studied, most sensitive area's deformation will not be missed, thus truer, stable reflection intraocular pressure fluctuation, while can measure
Including more points of interest data during the fact interior such as center, nearly angle Gong Yuan by corneal center, cornea, it is therefore particularly suitable for 24 hours
The clinical application of intraocular pressure monitoring.The initial value of inductance value can be set as 90nH~0.21mH (in i.e. undeformed situation), inductance value
Initial value can be adjusted by the spacing between circle number, average diameter and the helix of adjusting helix.
Also, forming microfibre pipeline present invention preferably employs silastic material, (silastic material has extremely low elasticity
Modulus), due to the extremely low mechanical strength of microfibre pipe, intraocular pressure can cause the very big variation of microfibre pipe inductance coil, can be real
The high precision real-time measurement for pressure of losing face, is provided simultaneously with that high sensitivity, dynamic range are big, stability is good, using comfortable and small in size
The advantages that light-weight.
Sensor in the present invention wirelessly monitors intraocular pressure, compared with the mode of wired measuring, more relaxes
Suitable, sensitivity is higher, can dynamically reflect the variation of intraocular pressure in real time；With strain chip non-invasive sensors and non-intrusion type
Change inductance type " LC- resonant transducer " etc. compare, present invention preferably employs EGaIn Galinstan liquid metal without
Poison, and have high conductivity (for example, resistivity can be 28 × 10-8Ω.m-1~29.4 × 10-8Ω.m-1), liquid metal is passed through
As inductance element, the Young's modulus of sensing unit is extremely low for microchannel, so that there is sensor higher flexibility and wearing to relax
Adaptive, while sensor has higher sensitivity.
To sum up, using in the present invention based on microfibre pipe power transformation sense wireless type intraocular pressure monitor sensor, when eyeball due to
When intraocular pressure fluctuation deforms, contact lens bending deformation, the inductance coil that microfibre pipe is constituted can be also deformed, thus
Cause the change of inductance value, and passes through external wireless module as feedback signal in a manner of capable of finally changing using resonance frequency
Read output.Power transformation sense wireless type intraocular pressure in through the invention based on microfibre pipe monitors sensor, can be according to nothing
Continuous measurement to intraocular pressure is realized in the variation of line resonance frequency, has easily manufactured quick, and high sensitivity, dynamic range are big, steady
The advantages that qualitative good.
Detailed description of the invention
Fig. 1 is the structural schematic diagram for being shown as the microfibre pipe for the spiral distribution that the present invention executes.
Fig. 2 is the structural side view of intraocular pressure monitoring sensor according to the invention.
Fig. 3 is the structure front view of intraocular pressure monitoring sensor according to the invention.
Fig. 4 is the test schematic of intraocular pressure monitoring sensor according to the invention.
The meaning of each appended drawing reference is as follows in figure: 1 is contact lens, and 2 be microfibre pipeline, and 3 be liquid metal, and 4 are
Patch capacitor (also known as thin capacitor), 5 be copper wire.
Specific embodiment
In order to make the objectives, technical solutions, and advantages of the present invention clearer, with reference to the accompanying drawings and embodiments, right
The present invention is further elaborated.It should be appreciated that the specific embodiments described herein are merely illustrative of the present invention, and
It is not used in the restriction present invention.As long as in addition, technical characteristic involved in the various embodiments of the present invention described below
Not constituting a conflict with each other can be combined with each other.
Fig. 2 is the structural side view of intraocular pressure monitoring sensor according to the invention, and Fig. 3 is intraocular pressure monitoring according to the invention
The structure front view of sensor.As shown in Figures 2 and 3, the intraocular pressure monitoring sensor mainly include soft contact lens 1,
The components such as the patch capacitor 4 of microfibre pipeline 2, the liquid metal 3 for being passed through pipeline and coupling, and pass through the structure to these components
And its researching and designing of set-up mode, mutually should be able to high-precision, 24 hours whole measurement intraocular pressures fluctuation status, while it is significant
The comprehensive of measurement data, authenticity and stability are improved, and ensures the comfortable applicability to patient.
Specifically, general medical cornea contact lense for example can be used in contact lens 1, it is in spherical crown shape, specification ruler
Very little to be decided to be diameter 12mm~18mm, thickness is less than 0.4mm, and its material is preferably PDMS, and for when wearing and patient
Eyeball shape be matchingly bonded.Microfibre pipe 2 insertion is arranged in inside the mirror plate layers of contact lens 1, not with eye
Eyeball directly contacts, and being inside passed through liquid metal room temperature liquid metal is nontoxic EGaIn or Galinstan, constitutes inductor
Part；As one of key improvements, its main body is set to the center helically annular spread around the contact lens, referring to
Fig. 1, the helix are two circles, and insertion is arranged in inside the mirror plate layers of the contact lens 1, and tail portion both ends are from the cornea
Contact lense 1 draws 50~100 microns of copper wire 5 and couples that (patch capacitor 4 can be packaged in contact lens 1 with patch capacitor 4
In mirror plate layers), constitute LC resonance formula sensor.The inductance range value of sensor is 90nH~0.21mH, patch capacitor value range
For 6.0~8.5pF, the resonant frequency range of sensor is 50~300MHz.When the intraocular pressure of eyeball changes, phase is born
The bending answered, which changes, leads to the variation of inductance, causes the change of LC sensor resonant frequency, by external wireless reading circuit or
Person's Network Analyzer or impedance analyzer etc. read the change of resonance frequency, realize 24 hours continuous prisons in real time to intraocular pressure
It surveys.
The circle number of microfibre pipe is for example 4 circles, the form row that it is spirally distributed around the center of the corneal basement mirror
Column, internal diameter are greater than pupil diameter 5mm, and when the intraocular pressure of eyeball changes, and bear to be bent to change accordingly to lead to electricity
The variation of sense causes the change of LC sensor resonant frequency, passes through external wireless reading circuit or Network Analyzer or resistance
Analysis resistant instrument etc. reads the change of resonance frequency, realizes 24 hours continuous real-time monitorings to intraocular pressure.
By conceiving above, above-mentioned contact lens and its attachment constitute one kind can input pressure, export simultaneously
Reflect that the intraocular pressure of eyeball deformation data monitors sensor.In particular, the mechanical strength that microfibre pipe is extremely low, intraocular pressure can cause micro-
The very big of fibre pipe inductance coil changes the high precision real-time measurement, it can be achieved that intraocular pressure, is provided simultaneously with high sensitivity, dynamic range
Greatly, the advantages that stability is good, using comfortable and small in volume.
In addition, the microfibre pipe of the present invention full of liquid metal, easy to make to the high sensitivity of pressure,
Easily operated use, it is smaller to human eye injury, it is therefore particularly suitable for the intraocular pressure sensor of all kinds of 24 hours real-time monitorings of needs
Purposes.
Patch capacitor of the present invention, can be 0201 patch capacitor, for example, length, width and height be respectively 0.60mm,
0201 patch capacitor of 0.30mm, 0.23mm；It is also possible to the patch capacitor of 01005 encapsulation, such as length, width and height are respectively
The patch capacitor of 01005 encapsulation of 0.40mm, 0.20mm, 0.2mm.
As it will be easily appreciated by one skilled in the art that the foregoing is merely illustrative of the preferred embodiments of the present invention, not to
The limitation present invention, any modifications, equivalent substitutions and improvements made within the spirit and principles of the present invention should all include
Within protection scope of the present invention.
Claims (8)
1. a kind of power transformation sense wireless type intraocular pressure based on microfibre pipe monitors sensor, which is characterized in that including contact lens
(1), microfibre pipeline (2), the liquid metal (3) being sealed in the microfibre pipeline (2), and it is micro- with this by copper wire (5)
The patch capacitor (4) that fiber conduit (2) and its interior liquid metal (3) are integrally coupled, in which:
The contact lens (1) is integrally in spherical crown shape, and is used for the progress that when wearing and the eyeball shape of patient matches
Fitting；
The microfibre pipeline (2) is embedded in inside the mirror plate layers of the contact lens (1), which surrounds
The center distribution spiral yarn shaped in the shape of a spiral of the contact lens (1), the head and the tail both ends of microfibre pipeline (2) entirety pass through
The copper wire (5) that diameter is 50~100 microns is drawn from the contact lens (1), and with the patch capacitor (4) phase coupling
It closes；
The microfibre pipeline (2) is at least the spiral yarn shaped of a full circle, the microfibre pipeline (2) and its interior liquid
Metal is integrally formed inductance component, couples with the patch capacitor (4) and constitutes LC resonance circuit, forms LC resonance formula sensor；
The inductance value of the inductance component is by Effect of Intraocular Pressure, so that the resonance frequency of the LC resonance formula sensor is led to equally by Effect of Intraocular Pressure
The variation for reading resonance frequency is crossed, the real-time sensing monitoring to intraocular pressure can be realized.
2. the power transformation sense wireless type intraocular pressure based on microfibre pipe monitors sensor as described in claim 1, which is characterized in that described
The internal diameter of microfibre pipeline (2) is less than or equal to 0.2mm, preferably 0.1~0.2mm；Outer diameter is 0.2~0.3mm.
3. the power transformation sense wireless type intraocular pressure based on microfibre pipe monitors sensor as described in claim 1, which is characterized in that described
The helical the distribution of line shape that microfibre pipeline (2) is enclosed around the center of the contact lens (1) in 2~4, and the spiral shell
The minimum diameter of spin line shape is greater than 5mm, and the inductance value of the inductance component meets 90nH~0.21mH.
4. the power transformation sense wireless type intraocular pressure based on microfibre pipe monitors sensor as described in claim 1, which is characterized in that described
The patch capacitor of patch capacitor or 01005 encapsulation that patch capacitor (4) encapsulates for 0201, and capacitance value range satisfaction 6.0~
8.5pF。
5. the power transformation sense wireless type intraocular pressure based on microfibre pipe monitors sensor as described in claim 1, which is characterized in that described
The resonance frequency of LC resonance formula sensor meets 50~300MHz.
6. the power transformation sense wireless type intraocular pressure based on microfibre pipe monitors sensor as described in claim 1, which is characterized in that described
The specification of contact lens (1) is set to diameter 12mm~18mm, and thickness is less than 0.4mm, and its material is preferably
PDMS。
7. the power transformation sense wireless type intraocular pressure based on microfibre pipe monitors sensor as described in claim 1, which is characterized in that described
Microfibre pipeline (2) uses silastic material, and the liquid metal (3) is sealed in the microfibre pipe also by silastic material
In road (2).
8. the power transformation sense wireless type intraocular pressure based on microfibre pipe monitors sensor as described in claim 1, which is characterized in that described
Liquid metal (3) is nontoxic, specially EGaIn or Galinstan.
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| CN201910629641.6A CN110292352A (en) | 2019-07-12 | 2019-07-12 | A kind of power transformation sense wireless type intraocular pressure monitoring sensor based on microfibre pipe |
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| CN201910629641.6A CN110292352A (en) | 2019-07-12 | 2019-07-12 | A kind of power transformation sense wireless type intraocular pressure monitoring sensor based on microfibre pipe |
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| CN112022088A (en) * | 2020-09-09 | 2020-12-04 | 中国科学院半导体研究所 | Variable capacitance intraocular pressure sensor based on microfluidics technology and system thereof |
| CN113907701A (en) * | 2021-10-08 | 2022-01-11 | 电子科技大学 | System for dynamically monitoring intraocular pressure in real time |
| EP4290298A1 (en) * | 2022-06-12 | 2023-12-13 | Pegavision Corporation | Contact lens |
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