CN110288610A - A kind of retina OCT hard exudate dividing method - Google Patents
A kind of retina OCT hard exudate dividing method Download PDFInfo
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- CN110288610A CN110288610A CN201910487189.4A CN201910487189A CN110288610A CN 110288610 A CN110288610 A CN 110288610A CN 201910487189 A CN201910487189 A CN 201910487189A CN 110288610 A CN110288610 A CN 110288610A
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- G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
- G06T7/00—Image analysis
- G06T7/10—Segmentation; Edge detection
- G06T7/11—Region-based segmentation
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- G06—COMPUTING; CALCULATING OR COUNTING
- G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
- G06T7/00—Image analysis
- G06T7/10—Segmentation; Edge detection
- G06T7/187—Segmentation; Edge detection involving region growing; involving region merging; involving connected component labelling
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- G06—COMPUTING; CALCULATING OR COUNTING
- G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
- G06T2207/00—Indexing scheme for image analysis or image enhancement
- G06T2207/20—Special algorithmic details
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- G06T2207/00—Indexing scheme for image analysis or image enhancement
- G06T2207/30—Subject of image; Context of image processing
- G06T2207/30004—Biomedical image processing
- G06T2207/30041—Eye; Retina; Ophthalmic
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Abstract
The invention discloses a kind of retina OCT hard exudate dividing methods, comprising: retina OCT image is input in trained U-net network model, obtains corresponding bianry image by propagated forward；By the bianry image and retina OCT image proportionally Weighted Fusion, characteristic image is obtained；Several characteristic points in the characteristic image are chosen as seed point, the maximum Fuzzy connected degree of seed point is calculated using maximum fuzzy connectedness algorithm, obtains the image for being partitioned into hard exudate region.The present invention has the advantages that robustness is good, segmentation precision is high.
Description
Technical field
The invention belongs to technical field of image processing, and in particular to a kind of retina OCT hard exudate dividing method.
Background technique
Current existing retina OCT hard exudate separation algorithms should mainly with traditional Region growing segmentation algorithm
Algorithm shortcomings are that the speed of growth is slower, and the dice coefficient of segmentation result is low, it is difficult to reach good segmentation effect, and algorithm
Robustness is poor.
Summary of the invention
It is an object of the invention to overcome deficiency in the prior art, a kind of retina OCT hard exudate segmentation side is provided
Method has the advantages that robustness is good, segmentation precision is high.
In order to achieve the above objectives, the present invention adopts the following technical solutions realization:
A kind of retina OCT hard exudate dividing method, described method includes following steps:
Retina OCT image is input in trained U-net network model, corresponding binary map is obtained by propagated forward
Picture；
By the bianry image and retina OCT image proportionally Weighted Fusion, characteristic image is obtained；
Several characteristic points in the characteristic image are chosen as seed point, seed point is calculated using maximum fuzzy connectedness algorithm
Maximum Fuzzy connected degree, obtain the image for being partitioned into hard exudate region.
Further, the method for the training U-net network model includes:
Using the retina OCT image with mark hard exudate region manually as training sample set；
Input of the retina OCT image of training sample concentration as U-net network model is chosen, and adjusts U-net network mould
The parameter information of type, until hard exudate area image can be extracted tentatively.
Further, the method also includes: carry out image before retina OCT image is input to U-net network model
Size normalized.
Further, selected weight is (0.5,0.5) when proportion weighted merges.
Further, include: using the method that maximum fuzzy connectedness algorithm is partitioned into hard exudate area image
It is spread according to selected seed point to surrounding pixel point, calculates surrounding pixel point to the maximum Connected degree of seed point, if
Maximum Connected degree is greater than preset fuzzy connectedness threshold value, this pixel is put into hard exudate region, otherwise, then by this picture
Vegetarian refreshments puts background area into.
Further, the fuzzy connectedness threshold value is 0.23.
Compared with prior art, the beneficial effects of the present invention are: using the view based on U-net in conjunction with fuzzy connectedness
Film OCT hard exudate partitioning algorithm, can more accurately be partitioned into seepage areas, can obtain ideal Dice coefficient, and
And the robustness of algorithm is higher.
Detailed description of the invention
Fig. 1 is the flow chart of the retina OCT hard exudate dividing method provided according to embodiments of the present invention；
Fig. 2 is the retina OCT exemplary diagram with hard exudate disease；
Fig. 3 is normal retina OCT exemplary diagram；
Fig. 4 is retina OCT original image used by the embodiment of the present invention；
Fig. 5 is the goldstandard of Fig. 4；
Fig. 6 is the output image that Fig. 4 is obtained after the segmentation of trained U-net network model；
Fig. 7 is the image after Fig. 4 and Fig. 6 Weighted Fusion；
Fig. 8 is the seed point chosen from Fig. 7 (black irises out part)；
Fig. 9 is the hard exudate area image that Fig. 4 uses dividing method provided in an embodiment of the present invention to obtain.
Specific embodiment
The invention will be further described below in conjunction with the accompanying drawings.Following embodiment is only used for clearly illustrating the present invention
Technical solution, and not intended to limit the protection scope of the present invention.
As shown in Figure 1, be the flow chart of retina OCT hard exudate dividing method provided in an embodiment of the present invention, including
Following steps:
S01: image preprocessing: image preprocessing: by original image resize at the size of 224*224 pixel, as shown in figure 4,
It is the retina OCT original image after resize, focal area is more, and there are many form is oozed out, with traditional method
It is difficult to divide.
S02: retina OCT image is input in trained U-net network model, is obtained and is corresponded to by propagated forward
Bianry image；
Deep learning model used in the present invention is U-net network, using 5 layers of U-net network, and layer and layer it
Between joined dropout means, prevent network over-fitting, cause the Generalization Capability of network poor.
The training method of U-net network model includes the following steps:
S02-1: using 100 retina OCT images with mark hard exudate region manually as training sample set；
As shown in Fig. 2, being the retina OCT exemplary diagram with hard exudate disease, Fig. 3 is the view of no hard exudate disease
Film OCT figure, it can be clearly seen that regional area has its pixel value of boxed area to differ greatly with peripheral region in Fig. 2, in " white
Block " shape.
S02-2: input of the retina OCT image of training sample concentration as U-net network model is chosen, and adjusts U-
The parameter information of net network model is obtained by propagated forward and is corresponded to until hard exudate area image can be extracted tentatively
Bianry image.As shown in Figure 6, it can be seen that result just have seepage areas blank, but detail section still with Fig. 5 institute
The goldstandard shown has a certain distance, it is therefore desirable to further algorithm process.
S03: after the processing by step S02, also some remaining informations are U-net network moulds in retina OCT original image
Type learn less than, but these information are also very helpful for finally obtaining a good result, therefore the present invention
Bianry image that method obtains S02 and retina OCT original image proportionally Weighted Fusion, obtain characteristic image.
In many experiments test, discovery (0.5,0.5) this weight segmentation effect is best, and Fig. 7 is original image and network
Export the Overlay of figure, it can be seen that the seepage areas of this picture clearly, is laid well for the processing of next step
Basis.
S04: several characteristic points in the characteristic image are chosen as seed point (i.e. point of interest), are connected using maximum is fuzzy
Degree of connecing algorithm calculates the maximum Fuzzy connected degree of seed point, is partitioned into hard exudate area image.
The present invention constructs field with the result that S03 is obtained, 1 ~ 4 point of interest is taken (to scheme in upper larger seepage areas
Heart point, shown in this such as Fig. 8 in black line iris out region), to be spread to surrounding pixel point, calculate remaining point and this put most
Big Connected degree puts this pixel in seepage areas into if maximum Connected degree is greater than optimal threshold 0.23, if being less than this threshold
Value, then put this pixel into background area.The image for being partitioned into hard exudate region will be finally obtained, as shown in Figure 9.
The above is only a preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art
For member, without departing from the technical principles of the invention, several improvement and deformations can also be made, these improvement and deformations
Also it should be regarded as protection scope of the present invention.
Claims (7)
1. a kind of retina OCT hard exudate dividing method, which is characterized in that described method includes following steps:
Retina OCT image is input in trained U-net network model, corresponding binary map is obtained by propagated forward
Picture；
By the bianry image and retina OCT image proportionally Weighted Fusion, characteristic image is obtained；
Several characteristic points in the characteristic image are chosen as seed point, seed point is calculated using maximum fuzzy connectedness algorithm
Maximum Fuzzy connected degree, obtain the image for being partitioned into hard exudate region.
2. retina OCT hard exudate dividing method according to claim 1, which is characterized in that the training U-net net
The method of network model includes:
Using the retina OCT image with mark hard exudate region manually as training sample set；
Input of the retina OCT image of training sample concentration as U-net network model is chosen, and adjusts U-net network mould
The parameter information of type, until hard exudate area image can be extracted tentatively.
3. retina OCT hard exudate dividing method according to claim 1 or 2, which is characterized in that the method is also wrapped
It includes: carrying out picture size normalized before retina OCT image is input to U-net network model.
4. retina OCT hard exudate dividing method according to claim 1, which is characterized in that when proportion weighted merges
Selected weight is (0.5,0.5).
5. retina OCT hard exudate dividing method according to claim 1, which is characterized in that using maximum fuzzy company
The method that degree of connecing algorithm is partitioned into hard exudate area image includes:
It is spread according to selected seed point to surrounding pixel point, calculates surrounding pixel point to the maximum Connected degree of seed point, if
Maximum Connected degree is greater than preset fuzzy connectedness threshold value, this pixel is put into hard exudate region, otherwise, then by this picture
Vegetarian refreshments puts background area into.
6. retina OCT hard exudate dividing method according to claim 1, which is characterized in that the fuzzy connectedness
Threshold value is 0.23.
7. retina OCT hard exudate dividing method according to claim 1, which is characterized in that the U-net network mould
For type using 5 layers of U-net network model, be added has dropout means between layers.
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