CN110279500B - Inflatable medicine slow-release bracket - Google Patents
Inflatable medicine slow-release bracket Download PDFInfo
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- CN110279500B CN110279500B CN201910701884.6A CN201910701884A CN110279500B CN 110279500 B CN110279500 B CN 110279500B CN 201910701884 A CN201910701884 A CN 201910701884A CN 110279500 B CN110279500 B CN 110279500B
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- Prior art keywords
- medicine
- release
- tube
- communicated
- drug
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- 239000003814 drug Substances 0.000 title claims abstract description 138
- 229940079593 drug Drugs 0.000 claims description 44
- 230000003902 lesion Effects 0.000 claims description 17
- 238000007789 sealing Methods 0.000 claims description 16
- 238000012377 drug delivery Methods 0.000 claims description 4
- 239000000463 material Substances 0.000 claims description 4
- 230000036285 pathological change Effects 0.000 description 10
- 231100000915 pathological change Toxicity 0.000 description 10
- 210000001331 nose Anatomy 0.000 description 6
- 229920006254 polymer film Polymers 0.000 description 6
- 208000000592 Nasal Polyps Diseases 0.000 description 5
- 230000009471 action Effects 0.000 description 4
- 210000004400 mucous membrane Anatomy 0.000 description 4
- 210000003695 paranasal sinus Anatomy 0.000 description 4
- 238000013268 sustained release Methods 0.000 description 4
- 239000012730 sustained-release form Substances 0.000 description 4
- 208000016366 nasal cavity polyp Diseases 0.000 description 3
- 229920006237 degradable polymer Polymers 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 210000003928 nasal cavity Anatomy 0.000 description 2
- 230000006978 adaptation Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000002674 endoscopic surgery Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000002980 postoperative effect Effects 0.000 description 1
- 201000009890 sinusitis Diseases 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
- A61M31/002—Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
- A61F2250/0067—Means for introducing or releasing pharmaceutical products into the body
- A61F2250/0068—Means for introducing or releasing pharmaceutical products into the body the pharmaceutical product being in a reservoir
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2210/00—Anatomical parts of the body
- A61M2210/06—Head
- A61M2210/0618—Nose
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Hematology (AREA)
- Anesthesiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Cardiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Vascular Medicine (AREA)
- Media Introduction/Drainage Providing Device (AREA)
Abstract
The application relates to the field of medical equipment and discloses an inflatable medicine slow-release bracket which comprises a support pipe frame and also comprises a one-way valve and an air inlet pipe communicated with the air inlet end of the one-way valve, wherein the support pipe frame comprises a medicine release pipe group and a medicine release piece pre-stored with slow-release medicine which are communicated with each other, the medicine release pipe group is airtight and communicated with the air outlet end of the one-way valve, and the medicine release piece is arranged on the medicine release pipe group.
Description
Technical Field
The invention relates to the field of medical appliances, in particular to an inflatable drug slow-release bracket.
Background
The sinuses, also known as paranasal sinuses and paranasal sinuses, are multiple air-containing bony cavities around the nasal cavity. The mucous membrane of the nasal sinuses is connected with the mucous membrane of the nose, so that the mucous membrane of the nose is inflamed, and the mucous membrane of the sinus cavity is often affected to cause nasosinusitis. It is currently believed that the cause of sinusitis is mainly infection in the sinuses due to sinus ostial obstruction caused by various causes, wherein nasal polyps are important causes of sinus ostial obstruction, and inflammatory stimulation of the sinuses in turn promote growth of nasal polyps, forming a vicious circle. Aiming at chronic nasosinusitis caused by nasosinusitis, the current treatment method mainly comprises the steps of cutting off the proliferated nasal polyp under the nasal endoscope, re-opening the nasal passage, and has the advantages of large operation wound, high cost, poor patient experience and certain psychological shadow.
According to the drug sustained-release stent disclosed in Chinese patent publication No. CN109394399A, the drug sustained-release stent comprises a stent and a polymer film, wherein the stent and the polymer film are connected together, the polymer film is a degradable polymer film or a non-degradable polymer film, and at least one layer of drug coating is arranged on the polymer film or the stent, so that the drug sustained-release stent has the effects of supporting and continuously administering drugs to a postoperative lesion position. Because the mechanical property of the polymer film bracket is obviously insufficient, the polymer film bracket can not be directly put into a nasal polyp lesion cavity, and the nasal cavity blocked by the nasal polyp is opened, the bracket can only be used in combination with nasal sinus endoscopic surgery, can not be used independently, and patients still need to do invasive surgery.
Disclosure of Invention
In view of the above problems, an object of the present invention is to provide an inflatable drug sustained-release stent which has a strong supporting force and can be implanted directly in an outpatient site to open a blocked nasal passage without performing an endoscopic nasal operation.
The above object of the present invention is achieved by the following technical solutions:
an inflatable medicine slow-release bracket comprises a support pipe rack, a one-way valve and an air inlet pipe communicated with the air inlet end of the one-way valve;
The support pipe rack comprises a medicine release pipe group and a medicine release piece, wherein the medicine release pipe group and the medicine release piece are communicated with each other, and the medicine release pipe group is airtight and communicated with the air outlet end of the one-way valve;
the medicine releasing component is arranged on the medicine releasing pipe group.
Through above-mentioned technical scheme, put into the pathological change department with inflatable medicine slowly-releasing support, inflate the support pipe support from the intake pipe, prop up pathological change department after making its support pipe support expand, treat pathological change department with the slow release of medicine by releasing the medicine piece, can adjust the holding power to pathological change department through adjusting the air input, the adaptability is stronger.
The invention is further provided with: the medicine releasing tube group comprises a plurality of first medicine releasing tubes which are symmetrically arranged and a plurality of second medicine releasing tubes which are symmetrically arranged;
one end of the first medicine release pipe is communicated with the air outlet end of the one-way valve, the second medicine release pipe is an annular pipe, and the other end of the first medicine release pipe is communicated with the second medicine release pipe.
The invention is further provided with: the second medicine release pipes are mutually crossed and communicated.
Through above-mentioned technical scheme, the symmetry sets up and releases the control that the composition department can be more even, conveniently props up the dynamics, has increased the area of contact that releases composition group and composition department, makes composition department can obtain even, abundant medication.
The invention is further provided with: the medicine release part comprises a medicine storage pipe wound on the medicine release pipe group and a medicine release hole arranged on the medicine storage pipe, the medicine storage pipe is internally loaded with the slow release medicine, and the medicine release hole is communicated with the medicine storage pipe.
Through the technical scheme, the medicine storage pipe and the medicine release holes wound on the medicine release pipe group can release the slow-release medicine more uniformly and in a large quantity.
The invention is further provided with: the one-way valve comprises a valve post, a sealing plate and an elastic piece;
An air cavity is formed in the valve column, and an air inlet hole and an air outlet hole are respectively formed in two ends of the valve column;
The elastic piece is fixedly arranged in the air cavity, one end of the elastic piece is close to the air outlet hole, the other end of the elastic piece is fixedly connected with the sealing plate, and the sealing plate seals the air inlet hole under the elastic force of the elastic piece.
Through the technical scheme, when no inflation is performed, the elastic part is used for pushing the sealing plate to seal the air inlet hole under the elastic action of the elastic part; when the air inlet pipe is inflated, the air flow pushes the sealing plate to move away from the air inlet hole against the elastic action of the elastic piece, and the air flow enters the air cavity along the gap between the air inlet hole and the wind shield to flow into the support pipe rack, so that the support pipe rack is inflated; when the inflation is stopped, the elastic piece pushes the sealing plate to seal the air inlet hole again, and the support pipe frame keeps expanding.
The invention is further provided with: the outer surface of the medicine storage tube is an elastic layer.
Through above-mentioned technical scheme, elastic surface and pathological change department contact reduce patient's discomfort, and the storage medicine pipe is inseparabler with the connection of pathological change department simultaneously, when the inflation of release medicine nest of tubes, can also extrude the storage medicine pipe to a certain extent, makes the release medicine release from the drug release hole.
The invention is further provided with: the inner wall of the medicine storage tube is provided with a plurality of pits.
Through the technical scheme, the existence of the pits can increase the maximum storage quantity of the medicines in the medicine storage tube and continuously provide the medicines for the lesion.
Compared with the prior art, the invention has the beneficial effects that:
Through putting into the pathological change department with inflatable medicine slowly-releasing support, aerify the support pipe support from the intake pipe, prop up pathological change department after making its support pipe support expand, treat pathological change department with the slow release of medicine by releasing the medicine piece, can adjust the holding power to pathological change department through adjusting the air input, the adaptability is stronger.
Drawings
FIG. 1 is a schematic diagram of the overall structure of the present invention;
FIG. 2 is a schematic view of a portion of the structure of the present invention (for showing a drug storage tube);
fig. 3 is a partial structural cross-sectional view (to show a one-way valve) of the present invention.
Reference numerals: 1. a support tube rack; 2. a one-way valve; 3. an air inlet pipe; 11. a group of drug releasing tubes; 12. a drug release member; 111. a first delivery tube; 112. a second drug release tube; 121. a drug storage tube; 122. a drug release hole; 21. a valve post; 22. a sealing plate; 23. an elastic member; 24. an air cavity; 25. an air inlet hole; 26. and an air outlet hole.
Detailed Description
The present invention will be described in detail below with reference to the accompanying drawings and examples.
An inflatable drug slow release bracket, as shown in figure 1, comprises a support pipe frame 1, a one-way valve 2 and an air inlet pipe 3 communicated with the air inlet end of the one-way valve 2. The support tube rack 1 includes a drug release tube group 11 communicating with each other and a drug release member 12 provided on the drug release tube group 11 (see fig. 2).
The drug delivery tube group 11 includes a plurality of first drug delivery tubes 111 arranged symmetrically and a plurality of second drug delivery tubes 112 arranged symmetrically. In this embodiment, the second drug release tubes 112 are annular tubes, and two second drug release tubes 112 are disposed in a sinusoidal manner and are mutually crossed and communicated, and the drug release tube set 11 thus disposed has a stronger adaptability to the uneven lesion. One end of the first medicine release tube 111 is communicated with the air outlet end of the one-way valve 2, and the other end of the first medicine release tube 111 is communicated with the second medicine release tube 112, so that the whole medicine release tube group 11 is in a symmetrical state.
The inflatable medicine slow-release bracket is placed in a lesion, the support pipe rack 1 is inflated from the air inlet pipe 3, the lesion is supported up after the support pipe rack 1 is inflated, the nasal passages which are blocked are opened, the medicine is slowly released by the medicine release piece 12 to treat the lesion, and the supporting force to the lesion can be adjusted by adjusting the air inflow, so that the adaptability is high. And the symmetrical arrangement of the medicine release tube groups 11 can more uniformly support the lesion, so that the control of the supporting force is facilitated, the contact area between the medicine release tube groups 11 and the lesion is increased, and the lesion can be uniformly and fully treated by the medicine.
As shown in fig. 2, the drug release member 12 includes a drug storage tube 121 wound on the second drug release tube 112 and a plurality of drug release holes 122 formed on the drug storage tube 121, the support tube frame 1 is made of an elastic non-degradable material, the drug storage tube 121 is made of a degradable material, and is loaded with a slow release drug, the drug storage tube 121 can be spirally wound and fixed on the first drug release tube 111 and the second drug release tube 112, so that the contact area between the drug storage tube and a lesion can be increased, the better effect of the drug can be achieved, more preferably, a plurality of hollow pipelines which are not communicated with each other can be formed inside the drug storage tube 121, and different slow release drugs can be respectively placed.
The outer surface of the medicine storage tube 121 is an elastic layer, the discomfort of a patient is reduced by the contact of the elastic surface and the lesion, meanwhile, the connection between the medicine storage tube 121 and the lesion is tighter, and when the medicine release tube group 11 is expanded, the medicine storage tube 121 can be extruded to a certain extent, so that the medicine is released from the medicine release holes 122. The inner wall of the medicine storage tube 121 is provided with a plurality of pits, so that the maximum storage amount of medicine in the medicine storage tube 121 can be increased, and the medicine can be continuously supplied to the lesion.
As shown in fig. 3, the unidirectional valve 2 comprises a valve post 21, a sealing plate 22 and an elastic member 23, wherein an air cavity 24 is formed in the valve post 21, an air inlet hole 25 and an air outlet hole 26 are respectively formed in two ends of the valve post 21, the elastic member 23 is fixedly arranged in the air cavity 24, one end of the elastic member is close to the air outlet hole 26, the other end of the elastic member is fixedly connected with the sealing plate 22, and the sealing plate 22 seals the air inlet hole 25 by the elastic force of the elastic member 23. One end of the air inlet pipe 3 is communicated with one side of an air inlet hole 25 of the valve column 21, the other end of the air inlet pipe 3 extends out of the outer part of the nose body to perform proper air inflation, the pressure between the bracket and a lesion can be controlled through the air inflation amount, meanwhile, the outer part of the nose body is convenient to inflate, the risk of air leakage caused by inflation in the inner part of the nose body is prevented, and after the air inflation, the soft air pipe is sheared off at a proper position in the inner part of the nose body.
When no inflation is performed, the elastic part 23 pushes the sealing plate 22 to seal the air inlet 25 under the elastic action; when the air inlet pipe 3 is inflated, the air flow pushes the sealing plate 22 to move away from the air inlet hole 25 against the elastic action of the elastic piece 23, and enters the air cavity 24 along the gap between the air inlet hole 25 and the wind shield to flow into the support pipe rack 1, so that the support pipe rack 1 is inflated; when the inflation is stopped, the elastic member 23 pushes the sealing plate 22 again to seal the air intake hole 25, and the support tube holder 1 is kept inflated.
The above description is only a preferred embodiment of the present invention, and the protection scope of the present invention is not limited to the above examples, and all technical solutions belonging to the concept of the present invention belong to the protection scope of the present invention. It should be noted that modifications and adaptations to the present invention may occur to one skilled in the art without departing from the principles of the present invention and are intended to be within the scope of the present invention.
Claims (4)
1. The inflatable medicine slow-release bracket comprises a support pipe rack (1) and is characterized by further comprising a one-way valve (2) and an air inlet pipe (3) communicated with the air inlet end of the one-way valve (2), wherein the support pipe rack (1) is inflated through the air inlet pipe (3), so that a lesion part is propped up after the support pipe rack (1) is inflated;
The support pipe rack (1) comprises a medicine release pipe group (11) and a medicine release piece (12) which are communicated with each other and pre-store slow release medicines, and the medicine release pipe group (11) is sealed and communicated with the air outlet end of the one-way valve (2);
the medicine release piece (12) is arranged on the medicine release tube group (11);
the medicine release part (12) comprises a medicine storage tube (121) wound on the medicine release tube group (11) and a medicine release hole (122) formed in the medicine storage tube (121), the support tube rack (1) is made of elastic non-degradable materials, the medicine storage tube (121) is made of degradable materials, the medicine storage tube (121) is internally loaded with the slow release medicine, and the medicine release hole (122) is communicated with the medicine storage tube (121);
a plurality of hollow pipelines which are not communicated with each other are arranged in the medicine storage tube (121);
The drug release tube group (11) comprises a plurality of first drug release tubes (111) which are symmetrically arranged and a plurality of second drug release tubes (112) which are symmetrically arranged;
one end of the first medicine release tube (111) is communicated with the air outlet end of the one-way valve (2), the second medicine release tube (112) is an annular tube, and the other end of the first medicine release tube (111) is communicated with the second medicine release tube (112);
the second medicine release pipes (112) are annular pipes, two second medicine release pipes (112) are mutually communicated and are in a sine curve shape.
2. The inflatable drug delivery stent according to claim 1, wherein the one-way valve (2) comprises a valve post (21) and a sealing plate (22) and an elastic member (23);
an air cavity (24) is formed in the valve column (21), and an air inlet hole (25) and an air outlet hole (26) are formed in two ends of the valve column (21) respectively;
The elastic piece (23) is fixedly arranged in the air cavity (24), one end of the elastic piece is close to the air outlet hole (26), the other end of the elastic piece (23) is fixedly connected with the sealing plate (22), and the sealing plate (22) is sealed by the elastic force of the elastic piece (23) to the air inlet hole (25).
3. The inflatable drug-eluting stent of claim 1, wherein the outer surface of the drug storage tube (121) is an elastic layer.
4. The inflatable drug-eluting stent of claim 1, wherein the inner wall of the drug storage tube (121) is provided with a plurality of dimples.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910701884.6A CN110279500B (en) | 2019-07-31 | 2019-07-31 | Inflatable medicine slow-release bracket |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910701884.6A CN110279500B (en) | 2019-07-31 | 2019-07-31 | Inflatable medicine slow-release bracket |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN110279500A CN110279500A (en) | 2019-09-27 |
| CN110279500B true CN110279500B (en) | 2024-07-09 |
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ID=68024504
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910701884.6A Active CN110279500B (en) | 2019-07-31 | 2019-07-31 | Inflatable medicine slow-release bracket |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN110279500B (en) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6355063B1 (en) * | 2000-01-20 | 2002-03-12 | Impra, Inc. | Expanded PTFE drug delivery graft |
| CN108742961A (en) * | 2018-04-04 | 2018-11-06 | 郑州大学第附属医院 | A kind of loading radion and the Esophageal Stent with chemotherapy liquid slow-release function |
| CN110056760A (en) * | 2019-05-24 | 2019-07-26 | 杭州富阳泳富机械有限公司 | A kind of pressurized tank |
| CN211095006U (en) * | 2019-07-31 | 2020-07-28 | 乐畅医疗器械(上海)有限公司 | Inflatable medicine slow-release stent |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014164308A1 (en) * | 2013-03-13 | 2014-10-09 | Boston Scientific Scimed, Inc. | Pancreatic stent drainage system |
| US20160287371A1 (en) * | 2015-04-02 | 2016-10-06 | Boston Scientific Scimed, Inc. | Devices and methods for dilating a lumen of a body |
-
2019
- 2019-07-31 CN CN201910701884.6A patent/CN110279500B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6355063B1 (en) * | 2000-01-20 | 2002-03-12 | Impra, Inc. | Expanded PTFE drug delivery graft |
| CN108742961A (en) * | 2018-04-04 | 2018-11-06 | 郑州大学第附属医院 | A kind of loading radion and the Esophageal Stent with chemotherapy liquid slow-release function |
| CN110056760A (en) * | 2019-05-24 | 2019-07-26 | 杭州富阳泳富机械有限公司 | A kind of pressurized tank |
| CN211095006U (en) * | 2019-07-31 | 2020-07-28 | 乐畅医疗器械(上海)有限公司 | Inflatable medicine slow-release stent |
Also Published As
| Publication number | Publication date |
|---|---|
| CN110279500A (en) | 2019-09-27 |
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Address after: Room 101 and 102, floor 1, No. 19, Lane 8666, Hunan Road, Xuanqiao Town, Pudong New Area, Shanghai Applicant after: LECHANG MEDICAL DEVICES (SHANGHAI) Co.,Ltd. Address before: Room 408, 4th Floor, 21 Building, No. 1-28 Lane 588 Tianxiong Road, Pudong New Area, Shanghai, 200120 Applicant before: LECHANG MEDICAL DEVICES (SHANGHAI) Co.,Ltd. |
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