CN110270682A - A kind of nano material and its manufacturing method - Google Patents
A kind of nano material and its manufacturing method Download PDFInfo
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- CN110270682A CN110270682A CN201810211451.8A CN201810211451A CN110270682A CN 110270682 A CN110270682 A CN 110270682A CN 201810211451 A CN201810211451 A CN 201810211451A CN 110270682 A CN110270682 A CN 110270682A
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- 238000004519 manufacturing process Methods 0.000 title claims abstract description 12
- 239000002086 nanomaterial Substances 0.000 title description 18
- 239000010410 layer Substances 0.000 claims abstract description 69
- 239000002105 nanoparticle Substances 0.000 claims abstract description 32
- 125000000524 functional group Chemical group 0.000 claims abstract description 27
- 239000002245 particle Substances 0.000 claims abstract description 17
- 239000000463 material Substances 0.000 claims abstract description 12
- 238000004132 cross linking Methods 0.000 claims abstract description 4
- 239000011229 interlayer Substances 0.000 claims abstract description 3
- 239000003446 ligand Substances 0.000 claims description 59
- 239000011241 protective layer Substances 0.000 claims description 44
- 125000003368 amide group Chemical group 0.000 claims description 9
- 229910052737 gold Inorganic materials 0.000 claims description 8
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 claims description 4
- 238000006243 chemical reaction Methods 0.000 claims description 4
- 125000003277 amino group Chemical group 0.000 claims description 3
- 229910052757 nitrogen Inorganic materials 0.000 claims description 3
- 229910018979 CoPt Inorganic materials 0.000 claims description 2
- 229910005335 FePt Inorganic materials 0.000 claims description 2
- UHYPYGJEEGLRJD-UHFFFAOYSA-N cadmium(2+);selenium(2-) Chemical compound [Se-2].[Cd+2] UHYPYGJEEGLRJD-UHFFFAOYSA-N 0.000 claims description 2
- 239000002131 composite material Substances 0.000 claims description 2
- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 claims description 2
- 229910052745 lead Inorganic materials 0.000 claims description 2
- 239000002184 metal Substances 0.000 claims description 2
- 229910052751 metal Inorganic materials 0.000 claims description 2
- 239000002077 nanosphere Substances 0.000 claims description 2
- 229910052697 platinum Inorganic materials 0.000 claims description 2
- 239000004065 semiconductor Substances 0.000 claims description 2
- 229910052709 silver Inorganic materials 0.000 claims description 2
- 125000001820 oxy group Chemical group [*:1]O[*:2] 0.000 claims 2
- 239000012736 aqueous medium Substances 0.000 claims 1
- 230000005389 magnetism Effects 0.000 claims 1
- 239000002070 nanowire Substances 0.000 claims 1
- 238000000034 method Methods 0.000 abstract description 14
- 239000010931 gold Substances 0.000 description 15
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 9
- 238000010586 diagram Methods 0.000 description 8
- 239000002356 single layer Substances 0.000 description 8
- 229920001223 polyethylene glycol Polymers 0.000 description 7
- 229920000962 poly(amidoamine) Polymers 0.000 description 6
- 239000000243 solution Substances 0.000 description 6
- 239000004094 surface-active agent Substances 0.000 description 6
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 description 5
- 239000002202 Polyethylene glycol Substances 0.000 description 5
- 230000008569 process Effects 0.000 description 4
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 3
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 3
- 238000006845 Michael addition reaction Methods 0.000 description 3
- 125000000320 amidine group Chemical group 0.000 description 3
- 239000007864 aqueous solution Substances 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 230000004048 modification Effects 0.000 description 3
- 238000012986 modification Methods 0.000 description 3
- LZZYPRNAOMGNLH-UHFFFAOYSA-M Cetrimonium bromide Chemical compound [Br-].CCCCCCCCCCCCCCCC[N+](C)(C)C LZZYPRNAOMGNLH-UHFFFAOYSA-M 0.000 description 2
- 241000209094 Oryza Species 0.000 description 2
- 235000007164 Oryza sativa Nutrition 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 230000003213 activating effect Effects 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 238000010276 construction Methods 0.000 description 2
- 239000000412 dendrimer Substances 0.000 description 2
- 229920000736 dendritic polymer Polymers 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 239000000178 monomer Substances 0.000 description 2
- 239000002073 nanorod Substances 0.000 description 2
- 235000009566 rice Nutrition 0.000 description 2
- FOVKHTSFPJLUQN-UHFFFAOYSA-N 1-ethoxy-1,3,5-triazinane-2,4,6-trione Chemical class CCON1C(=O)NC(=O)NC1=O FOVKHTSFPJLUQN-UHFFFAOYSA-N 0.000 description 1
- PUGOMSLRUSTQGV-UHFFFAOYSA-N 2,3-di(prop-2-enoyloxy)propyl prop-2-enoate Chemical compound C=CC(=O)OCC(OC(=O)C=C)COC(=O)C=C PUGOMSLRUSTQGV-UHFFFAOYSA-N 0.000 description 1
- CERQOIWHTDAKMF-UHFFFAOYSA-M Methacrylate Chemical compound CC(=C)C([O-])=O CERQOIWHTDAKMF-UHFFFAOYSA-M 0.000 description 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 1
- 239000005864 Sulphur Substances 0.000 description 1
- CKUAXEQHGKSLHN-UHFFFAOYSA-N [C].[N] Chemical compound [C].[N] CKUAXEQHGKSLHN-UHFFFAOYSA-N 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 description 1
- 230000003197 catalytic effect Effects 0.000 description 1
- 235000013339 cereals Nutrition 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000002059 diagnostic imaging Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 150000002148 esters Chemical group 0.000 description 1
- FDWREHZXQUYJFJ-UHFFFAOYSA-M gold monochloride Chemical compound [Cl-].[Au+] FDWREHZXQUYJFJ-UHFFFAOYSA-M 0.000 description 1
- 229910052738 indium Inorganic materials 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- 239000000696 magnetic material Substances 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- WXZMFSXDPGVJKK-UHFFFAOYSA-N pentaerythritol Chemical compound OCC(CO)(CO)CO WXZMFSXDPGVJKK-UHFFFAOYSA-N 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- QQONPFPTGQHPMA-UHFFFAOYSA-N propylene Natural products CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 description 1
- 125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 238000002371 ultraviolet--visible spectrum Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0052—Thermotherapy; Hyperthermia; Magnetic induction; Induction heating therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B22—CASTING; POWDER METALLURGY
- B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
- B22F1/00—Metallic powder; Treatment of metallic powder, e.g. to facilitate working or to improve properties
- B22F1/14—Treatment of metallic powder
- B22F1/145—Chemical treatment, e.g. passivation or decarburisation
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
- C09D7/00—Features of coating compositions, not provided for in group C09D5/00; Processes for incorporating ingredients in coating compositions
- C09D7/40—Additives
- C09D7/60—Additives non-macromolecular
- C09D7/61—Additives non-macromolecular inorganic
- C09D7/62—Additives non-macromolecular inorganic modified by treatment with other compounds
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01D—MEASURING NOT SPECIALLY ADAPTED FOR A SPECIFIC VARIABLE; ARRANGEMENTS FOR MEASURING TWO OR MORE VARIABLES NOT COVERED IN A SINGLE OTHER SUBCLASS; TARIFF METERING APPARATUS; MEASURING OR TESTING NOT OTHERWISE PROVIDED FOR
- G01D5/00—Mechanical means for transferring the output of a sensing member; Means for converting the output of a sensing member to another variable where the form or nature of the sensing member does not constrain the means for converting; Transducers not specially adapted for a specific variable
- G01D5/26—Mechanical means for transferring the output of a sensing member; Means for converting the output of a sensing member to another variable where the form or nature of the sensing member does not constrain the means for converting; Transducers not specially adapted for a specific variable characterised by optical transfer means, i.e. using infrared, visible, or ultraviolet light
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- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Inorganic Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Physics & Mathematics (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Powder Metallurgy (AREA)
Abstract
The present invention relates to a kind of stable nanometer particle materials and similar system and its manufacturing method.This method includes forming stabilized protection course, and external connection functional group is reserved on layer using modes such as crosslinkings in multilayer covering, interlayer connection, layer on nanoparticle.
Description
Technical field
The present invention relates to a kind of nano material and its manufacturing method more particularly to it is a kind of for stable nano material or
Similar system and its manufacturing method.
Background technique
Diameter has high electron density, dielectric property in nanogold particle, nano gold spherical, nanometer gold bar of 1~100nm etc.
And catalytic action, it can be in conjunction with a variety of large biological molecules, and its bioactivity is not influenced.Be widely used in life medicine (including
Oncotherapy, medical imaging, medicine quickly detect), can be used for infrared detector, effectively insulating energy-saving coatings etc. etc.,
Application prospect is extensive.
A major issue in the application of nanogold is stability.It is too long between when left, solution environmental changes,
Whens temperature change etc., nano Au particle is easy to be lost protective layer, surfactant etc., then loses the characteristic of nanoparticle.
Therefore, the stability for improving nano Au particle is necessary to large-scale application nano Au particle.
The present invention provides a kind of stable nano Au particle materials and similar system and its manufacturing method.
Summary of the invention
The present invention relates to a kind of stable nano Au particle materials and similar system and its manufacturing method.This method is included in
Using modes such as crosslinkings in multilayer covering, interlayer connection, layer on nano Au particle, stabilized protection course is formed, and reserve on layer
External connection functional group.
In one embodiment of the invention, a kind of structure of nano material with stabilized protection course is provided.The structure is adopted
Replace the surfactant in former nano material with new double shielding layer structure, improves the stability of nanoparticle and reservation
Protective layer activity.
A kind of method of nano material of the manufacture with stabilized protection course is provided in another embodiment of the present invention.The party
Method includes generating initial nanoparticle, certain concentration, temperature, etc. under the conditions ofs the new ligand of multilayer is added, generate to stablize and protect
Sheath.
Invention embodiment
A specific embodiment of the invention explained below, it should be pointed out that in the specific descriptions process of these embodiments
In, in order to carry out brief and concise description, this specification can not all features to actual embodiment make in detail
Description.It is to be understood that during the actual implementation of any one embodiment, as in any one engineering item
During mesh or design object, in order to realize the objectives of developer, in order to meet, system is relevant or business phase
The limitation of pass can usually make various specific decisions, and this also can be from a kind of embodiment to another embodiment
Between change.Although moreover, it is to be understood that the effort gone out done in this development process may be it is complicated and
It is interminable, however for those skilled in the art relevant to present disclosure, it is disclosed in the disclosure
Technology contents on the basis of some designs for carrying out, the changes such as manufacture or production are conventional technology, should not
It is insufficient to be interpreted as content of this disclosure.
Nano Au particle can be prepared various different grains in which can be convenient by gold chloride by modes such as reduction method, crystal seed methods
The nano Au particle of diameter.But in gold nanoparticle forming process, the surfactant stability on gold particle surface is poor, again
Such as the surfactants such as CTAB have bio-toxicity, when nanoparticle is applied to the fields such as medicine, need to remove such table
Face activating agent.But nano Au particle can decompose the characteristic for losing nanoparticle after only removing surfactant.So needing
It is modified that surface is carried out to nano particle.
Popular method can be attached on gold nano-material with the functional group containing sulfydryl, for example sulfhydrylation is poly-
Ethylene glycol (Thiolated polyethylene glycol, HS-PEG), sulfydryl-DNA or other containing amido (NH2-)
Some functional groups.It only can not achieve with these functional groups and good covering carried out to the surface of nanometer rods, and because do not have
Have good locking mechanism, there is no assurance that these ligands can stay in gold surface, be cleaned multiple times or when and particle surface
When having the ligand of stronger compatibility to occur, these ligand moleculars can fall off, and so as to cause stability decline, even result in and receive
Rice corpuscles finally reunites and precipitates.
The present invention uses the ligand of multilayer, is attached in nanoparticle surface with locking protective layer.Of the invention one
In a embodiment, first layer is attached directly to nanoparticle surface with covalent bond.The ligand of first layer includes at least two functions
Group, the functional group of one of ligand is connected by covalent bond with particle surface, the functional group of another ligand can be with
The functional group of the ligand of the second layer is connected, while the ligand of dentate can be crosslinked connection in same layer.
In one embodiment of the invention, first layer stabilized zone may include the ligand with multiple attachment points, can be with
It is two-dimentional ligand or three-dimensional ligand.The former free binding site in part has been attached in nanoparticle surface on ligand.There are also parts
Free binding site does not react, can be reacted with other ligands.Because having multiple binding sites and nanometer rods on the ligand
Surface be connected, so from nanorod surfaces be detached from degree with regard to relatively low.
In one embodiment of the invention, there is one layer of first layer first layer ligand directly adhered in nanorod surfaces
In there are two above functional group, the ligand of first layer can be attached to by reaction appropriate with the head functional group for guaranteeing ligand
The ligand in face can be crosslinked mutually by organo-functional group on the first layer in nanometer rods.These interlockings can effectively reduce first layer
Stabilized zone is from the probability of the disengaging above nanoparticle.It also include that unreacted functional group can be in ligand on first layer
Other layers such as second layer reacts.
In one embodiment, may include in the ligand of first layer it is some containing nitrogen, sulphur, phosphorus, oxygen element atom
Functional group.Such as some dendron shaped polymer molecules, polyamidoamine dendrimer poly (amidoamine)
(PAMAM) etc..These molecules have tree-shaped structure, and can extend to more branches.With increasing for branch, divide
Son can become bended.After multiple extension, there is the binding site of some amidos that can be attached to nanoparticle surface, have simultaneously
Some unattached binding sites.
In one embodiment, these ligands can be two-dimensional, and two-dimentional ligand can also be some and contain amine simultaneously
The ligand of base and the monomer of acrylate-functional groups, such as poly- (2- amidoethyl methacrylate-co- methacrylic acid
Methyl esters etc..In one embodiment of the invention, two-dimentional ligand may include containing amido and acrylate-functional groups simultaneously
Monomer ligand it is for example poly- (2- amidoethyl methacrylate-co- methyl methacrylate).In one embodiment
In, these ligands can be it is three-dimensional, three-dimensional ligand may include it is some there are three or the above functional group while at least
Liang Ge functional group can molecule in the same plane, such as protein, peptide or synthesis macromolecule etc..
Fig. 1 is the schematic diagram of one embodiment of nano material of the present invention, around nanoparticle 1, new single layer first
Layer protective layer 2 replaces original protective layer 0, the two-dimentional or three-dimensional ligand that can also be introduced in second layer ligand.Second layer ligand
It can combine in several ways on the first layer.In one embodiment of the invention, on second layer ligand and first layer
Combination between functional group is by carbon-nitrogen covalent bond.Such as the covalent bond can be through the acrylate on the second layer
What the free amino functional group in functional group and first layer was formed by Michael addition reaction (Michael Addition).?
In one embodiment, the ligand comprising acrylate-functional groups can be the acrylate ended that molecular weight is 1000-20000
Polyethylene glycol acrylate-terminated polyethylene glycol, the ligand containing amidine functional group can be
Molecular weight is the polyamidoamine dendrimer of 1000-100000, Polyamidoamine (PAMAM).In a reality
It applies in example, the combination between second layer ligand and first layer is to pass through amido bond.Such as pass through the anti-of carboxylic acid and amidine functional group
It answers.In one embodiment, ligand in the second layer may include that multiple free binding sites with stabilized zone are formed altogether
The functional group of valence link.In one embodiment, these functional groups can be acrylate-functional groups and amidine functional group.At one
In embodiment, second layer ligand may include multiple acrylate-functional groups, such as double pentaerythritol C5 methacrylate, the third oxidation
Glycerol tri-acrylate or three (2- ethoxy) isocyanuric acids etc..These multi-functional ligands can in first layer stabilized zone
Ligand link can also be connect with extrinsic ligand such as long-chain amine end groups ligand etc..
Fig. 2 is the schematic diagram of one embodiment of nano material of the present invention, around nanoparticle 1, new single layer first
Layer protective layer 2 replaces original protective layer 0, increases by the second protective layer again outside first layer protective layer.
Fig. 3 is the schematic diagram of one embodiment of nano material of the present invention, around nanoparticle 1, new single layer first
Layer protective layer 2 replaces original protective layer 0, increases the second protective layer, the second protective layer interior molecules again outside first layer protective layer
Form cross-linked structure.
Fig. 4 is the schematic diagram of one embodiment of nano material of the present invention, around nanoparticle 1, new single layer first
Layer protective layer 2 replaces original protective layer 0, increases the second protective layer, the second protective layer interior molecules again outside first layer protective layer
Cross-linked structure, while second layer molecule also contact nanometer particle surface are formed, forms intersection construction with first layer.
A kind of method of nano material of the manufacture with stabilized protection course is provided in one embodiment of the invention.This method
Including generating initial nanoparticle, certain concentration, temperature, etc. under the conditions ofs new surfactant is added, generate protective layer
Deng.
In one embodiment of the invention, all these, which react (including increasing ligand layer, the reaction such as crosslinking), is all
It is completed in water or aqueous solution.Reaction between different ligands can carry out at room temperature, for example, PEG layers can be with
It is manufactured using following steps: the aqueous solution addition of the amido end ligand containing 0.00001 M to 0.5M being had into CTAB first
In the gold nanorods solution of covering, to adhere to the stabilized zone that one layer of amido end ligand is formed on gold nanorods.It is small at one
When after, by the acrylate-based aqueous solution of the multifunctional chiral ligand such as triglycerin containing 0.00001 M to 0.001 M
It is added in solution, after solution is stirred 20 minutes, the second layer is connected together by Michael addition reaction with stabilized zone.
Unreacted acrylate-functional groups can be used to be reacted with the ligand containing amido envelope functional group of long-chain or short chain.
In one embodiment, short chain ligand can be 6-aminocaprolc acid.In one embodiment, it is poly- to can be amido end for long-chain Ligand
Ethylene glycol.
In one embodiment, by the way that the long-chain or short chain that concentration is 0.00001M to 0.1 M are contained propylene
The solution of acid esters end group ligand is added in nano-particle solution, can be by acrylate end groups ligand, such as acrylate end groups
Polyethylene glycol is reacted with the ligand on the stabilized zone of nanometer rods, carbon-to-nitrogen covalent bond is formed, to be attached on stabilized zone.
The replacement process of protective layer can be detected by UV-Vis spectrum, attachment mew layer can spectrally form the peak LSPR
Red shift or blue shift, so as to determine whether to complete the replacement of layer molecule.TEM can also be used to the steady of detection extra play
It is qualitative.
In some embodiments, diameter of nano particles is between 2nm-10nm, in some embodiments, nanoparticle it is straight
Diameter is between 10nm -30nm, in some embodiments, the diameter of nanoparticle between 30nm -200nm,.
In embodiments of the present invention, " nanoparticle " used herein can refer to comprising can be nanometer rods, nanosphere, nanometer
The various shapes such as line, can be metal (such as Au, Ag, Pt, Pb), semiconductor material (such as CdSe, CdS, ZnS,
TiO2, PbS etc.), magnetic material (such as Fe2O3 or Co nano particle) and composite material (such as FePt, CoPt).It receives
Rice material surface can be attached with activating agent, stabilizer.In some embodiments, nanoparticle can be with multiple actives
Or the gold nanorods of protective layer package.
" layer " being related in the present invention includes the material or component for having thickness formed on a surface, not generation
The specific thickness or other geometry dimensions of these materials of table or component." nano material " being related in the present invention include
In the material that scale is 1-1000nm, the specific scale or other geometry dimensions of these materials or component are not represented.
Unless otherwise defined, technical term or scientific term used in claims and specification should be this hair
The ordinary meaning that personage in bright technical field with general technical ability is understood.Present patent application specification and power
" first ", " second " used in sharp claim and similar word are not offered as any sequence, quantity or importance, and
It is used only to distinguish different component parts.The similar word such as "one" or " one " is not offered as quantity limitation, but indicates
There are at least one.The similar word such as " comprising " or "comprising" means to appear in the element before " comprising " or "comprising"
Either object covers the element for appearing in " comprising " or "comprising" presented hereinafter or object and its equivalent element, it is not excluded that
Other elements or object." connection " either the similar word such as " connected " is not limited to physics or mechanical connection,
It is also not necessarily limited to direct or indirect connection.
Although the present invention is described in conjunction with the specific embodiments, it will be appreciated by those skilled in the art that right
The present invention can make many modifications and variations.It is therefore contemplated that claims are intended to be covered on the present invention very
All such modifications and modification in positive conception and scope.
Detailed description of the invention
The embodiment of the present invention is described in conjunction with the accompanying drawings, the present invention may be better understood, in the accompanying drawings:
Fig. 1 is the schematic diagram of one embodiment of nano material of the present invention, and around nanoparticle 1, new single layer first layer is protected
Sheath 2 replaces original protective layer 0.
Fig. 2 is the schematic diagram of one embodiment of nano material of the present invention, around nanoparticle 1, new single layer first
Layer protective layer 2 replaces original protective layer 0, increases by the second protective layer again outside first layer protective layer.
Fig. 3 is the schematic diagram of one embodiment of nano material of the present invention, around nanoparticle 1, new single layer first
Layer protective layer 2 replaces original protective layer 0, increases the second protective layer, the second protective layer interior molecules again outside first layer protective layer
Form cross-linked structure.
Fig. 4 is the schematic diagram of one embodiment of nano material of the present invention, around nanoparticle 1, new single layer first
Layer protective layer 2 replaces original protective layer 0, increases the second protective layer, the second protective layer interior molecules again outside first layer protective layer
Cross-linked structure, while second layer molecule also contact nanometer particle surface are formed, forms intersection construction with first layer.
Claims (9)
1. a kind of nanometer material structure and its manufacturing method, including using in multilayer covering, interlayer connection, layer on nanoparticle
The modes such as crosslinking form stabilized protection course, and external connection pipe energy unity chalaza is reserved on layer.
2. multiple protective layers as claimed in claim 1, the functional group of the dentate of first layer includes one or more mismatch
Electronics.
3. multiple protective layers as claimed in claim 1, the functional group in the ligand of first layer includes sulfydryl, in amido, oxygroup
One or a combination thereof, it can be including acrylate-functional groups or amine functional group or simultaneously including the two, can wrap
Third functional group is included, and it is coplanar for having at least two in three functional groups.
4. the dentate of multiple protective layers as claimed in claim 1, first layer can be with one or more two-dimentional ligand or three
Ligand is tieed up, may include one or more kinds of dendritics.
5. multiple protective layers as claimed in claim 1, the functional group in the ligand of the second layer includes sulfydryl, in amido, oxygroup
One or a combination thereof, it can be including acrylate-functional groups or amine functional group or simultaneously including the two, can wrap
Third functional group is included, and it is coplanar for having at least two in three functional groups.
6. the dentate of multiple protective layers as claimed in claim 1, the second layer can be with one or more two-dimentional ligand or three
Ligand is tieed up, may include one or more kinds of dendritics.
7. multiple protective layers as claimed in claim 1, the second layer is by C-N, and C-C's or a combination thereof is covalently bonded to
On one layer.
8. multiple protective layers as claimed in claim 1, are attached to particle surface for first layer and the second layer are attached to first layer
On reaction complete in an aqueous medium at a certain temperature.
9. nanoparticle as claimed in claim 1 " can refer to comprising can be the various shapes such as nanometer rods, nanosphere, nano wire, can
To be metal (such as Au, Ag, Pt, Pb), semiconductor material (such as CdSe, CdS, ZnS, TiO2, PbS), magnetism
Material (such as Fe2O3 or Co nano particle) and composite material (such as FePt, CoPt).
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| CN102526769A (en) * | 2010-09-28 | 2012-07-04 | 谢达斌 | Double-developer for CT and MRI simultaneously and preparation method thereof |
| US20150038578A1 (en) * | 2011-05-16 | 2015-02-05 | Babak NIKOOBAKHT | Methods and apparatuses for surface functionalization and coating of nanocrystals |
| CN107737945A (en) * | 2017-09-12 | 2018-02-27 | 南京邮电大学 | A kind of synthetic method of composite Nano gold grain and application |
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| CN101679022A (en) * | 2007-04-02 | 2010-03-24 | 爱默蕾大学 | in vivo tumor targeting and spectroscopic detection with surface-enhanced raman nanoparticle tags |
| CN102526769A (en) * | 2010-09-28 | 2012-07-04 | 谢达斌 | Double-developer for CT and MRI simultaneously and preparation method thereof |
| US20150038578A1 (en) * | 2011-05-16 | 2015-02-05 | Babak NIKOOBAKHT | Methods and apparatuses for surface functionalization and coating of nanocrystals |
| CN107737945A (en) * | 2017-09-12 | 2018-02-27 | 南京邮电大学 | A kind of synthetic method of composite Nano gold grain and application |
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