CN110269658A - A kind of outspoken fast closer of vascular puncture of degradable in vivo and its operating method - Google Patents
A kind of outspoken fast closer of vascular puncture of degradable in vivo and its operating method Download PDFInfo
- Publication number
- CN110269658A CN110269658A CN201810212662.3A CN201810212662A CN110269658A CN 110269658 A CN110269658 A CN 110269658A CN 201810212662 A CN201810212662 A CN 201810212662A CN 110269658 A CN110269658 A CN 110269658A
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- China
- Prior art keywords
- closer
- delivery pipe
- disk
- drag wire
- hangnail
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 230000002792 vascular Effects 0.000 title claims abstract description 28
- 238000001727 in vivo Methods 0.000 title claims abstract description 21
- 238000011017 operating method Methods 0.000 title abstract description 7
- 206010058109 Hangnail Diseases 0.000 claims abstract description 21
- 239000000463 material Substances 0.000 claims abstract description 9
- 238000001523 electrospinning Methods 0.000 claims abstract 2
- 239000000203 mixture Substances 0.000 claims abstract 2
- 229940030225 antihemorrhagics Drugs 0.000 claims description 15
- 230000000025 haemostatic effect Effects 0.000 claims description 15
- 210000004204 blood vessel Anatomy 0.000 claims description 13
- 238000003780 insertion Methods 0.000 claims description 11
- 230000037431 insertion Effects 0.000 claims description 11
- 238000013459 approach Methods 0.000 claims description 2
- 239000007787 solid Substances 0.000 claims 1
- 238000000034 method Methods 0.000 abstract description 7
- 229920001606 poly(lactic acid-co-glycolic acid) Polymers 0.000 abstract description 3
- 238000005253 cladding Methods 0.000 abstract description 2
- 230000015556 catabolic process Effects 0.000 abstract 1
- 238000006731 degradation reaction Methods 0.000 abstract 1
- 239000012943 hotmelt Substances 0.000 abstract 1
- 210000004914 menses Anatomy 0.000 description 4
- 230000002980 postoperative effect Effects 0.000 description 4
- 238000005516 engineering process Methods 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 238000003745 diagnosis Methods 0.000 description 2
- ZZUFCTLCJUWOSV-UHFFFAOYSA-N furosemide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC(C(O)=O)=C1NCC1=CC=CO1 ZZUFCTLCJUWOSV-UHFFFAOYSA-N 0.000 description 2
- 206010033675 panniculitis Diseases 0.000 description 2
- 210000004304 subcutaneous tissue Anatomy 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- 206010028980 Neoplasm Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 210000001367 artery Anatomy 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 238000002059 diagnostic imaging Methods 0.000 description 1
- 210000002249 digestive system Anatomy 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 210000001105 femoral artery Anatomy 0.000 description 1
- 210000002216 heart Anatomy 0.000 description 1
- 238000013152 interventional procedure Methods 0.000 description 1
- 238000007913 intrathecal administration Methods 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 230000004807 localization Effects 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 239000002120 nanofilm Substances 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000000472 traumatic effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B17/12099—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder
- A61B17/12109—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder in a blood vessel
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B17/12131—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
- A61B17/1214—Coils or wires
- A61B17/1215—Coils or wires comprising additional materials, e.g. thrombogenic, having filaments, having fibers, being coated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00831—Material properties
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B2017/12004—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord for haemostasis, for prevention of bleeding
Abstract
The invention discloses a kind of outspoken fast closer of the vascular puncture of degradable in vivo and its operating methods.The closer is using degradation material in organism, such as PLGA makes closer and its drag wire using hot melt techniques, hangnail is made on drag wire, PLGA overlay film cladding is carried out to closer skeleton with high-pressure electrostatic micro-nano electrospinning again, forms the closer disk that front end easy entry folds.The closer includes the hangnail on closer disk, drag wire and drag wire as fixed closer disk.Transport portion includes delivery pipe and delivery pipe positioning head composition.The closer can realize the quick-make to vascular puncture mouth.
Description
Technical field
Present invention introduces a kind of outspoken fast closer of the vascular puncture of degradable in vivo and its operating methods.
Background technique
Since Whole Body is throughout naturally occurring blood vessel access, target organ or the people for arriving at human body are intervened using intravascular
Body target area is the most minimally invasive and efficiently approach.It is domestic in recent years widely to have promoted this leading in medical imaging device
Under drawing, many vitals of super selective intervention human body and position, such as: heart, liver, brain, kidney, digestive system and system genitale
System, to carry out the important technology and method of diagnosing and treating.However, intravascular intervention diagnosis and therapy is postoperative, it is closed vascular puncture mouth
Often become problem clinically.
As occurred, closure is bad to easily cause the big bleeding in site of puncture, traumatic artery to puncture orifice after intravascular interventional procedure
Tumor, distal vessels obstruction etc., also usually need to lie in bed for a long time when carrying out femoral artery puncture intervention etc..It is external also to have blood at present
Pipe seam clutch, but need to suture, and its construction is more complex, operating procedure is more, such as the Perclose Proglide of Abott company
Blood vessel suture instrument；It is some due to intravascular closure material fixation problem and to be collapsed if the Angio-seal of St Jude company
Solution absorption pattern and easily lead to blood vessel distal end occlude and close it is bad.
Summary of the invention
The present invention is solved the above problems by following technologies and scheme offer:
Using the production of vivo biodistribution degradable material closer over time, as intravascular and internal after 2-3 months
By noresidue substance, vascular wall is repaired, and former vascular puncture position can carry out puncture procedure again.
The puncture orifice closer external member include stop whithin a period of time in the blood vessels with intracorporal degradable material part,
That is closer disk and attached barbed drag wire, and the delivery pipe section with positioning head.The degradable material part is except most
Outside the closer disk of front end, rest part is loaded into delivery pipe.Delivery pipe positioning head is temporarily fixed at length by rotation
(referring to attached drawing 3) when equivalent and short sheath overall length, the haemostatic valve insertion closer disk through short sheath and delivery pipe are until delivery pipe at this time
When positioning head is resisted against the connector haemostatic valve of short sheath, closer disk is automatically opened in Endovascular (referring to Fig. 6)；Unscrew delivery pipe
Positioning head extracts short sheath and closer delivery pipe together, draws drag wire outward, and so far, closer disk is close to vascular puncture
Mouthful inner wall, when pulling out drag wire outside, hangnail discharges out of delivery pipe and becomes outside the blood vessel of fixed closer fixture (referring to figure
7).Drag wire is mentioned outside, the light skin pressed around drag wire cuts off and exposes extracutaneous drag wire, and bandage covers point of puncture skin
Skin (referring to Fig. 8).
Further, the closer skeleton of the vascular puncture mouth closer, coat the micro-nano film net of skeleton, drag wire and
Drawing hangnail is entirely that degradable in vivo material PLGA etc. is used to be made, and can be degraded in 2-3 months after merging in vivo.
Further, the skeleton of the vascular puncture mouth closer disk and drag wire are by melting making, closer disk
Micro-nano overlay film be using high-pressure electrostatic micro-nano spin cladding production.
Further, the conveying of the vascular puncture mouth closer is by including delivery pipe and delivery pipe positioning head two
Point, delivery pipe positioning head is a certain position for being fixed on delivery pipe by that can pass through rotation, for determining that delivery pipe insertion is short intrathecal
Depth localization.Due to the present invention claims delivery pipe setting length it is consistent with the overall length of intravascular short sheath, thus when convey
In closing process, when haemostatic valve of the delivery pipe positioning head against short sheath, closer disk is projected into lumen of vessels from front of short sheath
It is interior and automatically open discoid.
Operating method
The operating method of the outspoken fast closer of a kind of vascular puncture of degradable in vivo, it is characterised in that: this method includes
Following steps:
1) rotation of the setting delivery pipe locator in delivery pipe stops fixed position: the positioning head rotation in delivery pipe stops fixed part
Position is equal to the overall length of short sheath, and positioning head rotation is fixed on to the corresponding site of delivery pipe.
2) the drag wire end of the closer is closed from the insertion of the front end of delivery pipe until hangnail fully enters in delivery pipe
Device disk is closed to rest on outside delivery pipe.
3) will closer disk fold after from short sheath haemostatic valve be inserted into, and continue will equipped with drag wire delivery pipe insertion until
Delivery pipe positioning head is resisted against at the haemostatic valve of short sheath.At this point, closer disk automatically opened in Endovascular it is discoid.
4) short sheath is extracted together together with delivery pipe positioning head, delivery pipe, is exited external.
5) lift and draw outward drag wire, the light skin pressed around drag wire wipes out the body of drag wire after the completion of closing
Outer portion.
More existing vascular puncture mouth closer and shutoff operation technology, the beneficial effects of the present invention are:
1) the outspoken fast closer of degradable in vivo vascular puncture of the invention is by biocompatibility degradable in vivo material
It constitutes, foreign is detained in vivo after postoperative a period of time, and vascular wall is automatically repaired.
2) size for only changing closer disk is the intervention diagnosis and therapy vascular puncture mouth for being convenient to closure all size.
3) intra-operative procedures are enormously simplified, medical staff, which operates this instrument only, needs very short learning cycle that can slap
It holds.
4) it is close to endovascular closer disk since closer of the invention is existing and subcutaneous fixed hangnail, puncture orifice is closed
Conjunction works well, and is conducive to postoperative patient own activity without postoperative restrictions such as patient's beds.
Detailed description of the invention
Fig. 1, the closer and delivery pipe of degradable material production
1 closer disk
2 hangnails
3 delivery pipe tube bodies
4 delivery pipe positioning heads
5 drag wires
Fig. 2, with the closer component for closing disk skeleton, fixed hangnail, drag wire；
1 closer disk skeleton
2 closers subcutaneously fix hangnail
3 drag wires
Fig. 3 has coated the closer overall picture of closer skeleton part through high-pressure electrostatic micro-nano net；
Fig. 4, the closer being mounted in conveyer pay attention to closer disk still in front end；
1 closer disk
The hangnail being extruded inward after 2 loading conveyers
The delivery pipe section of 3 conveyers
4 closer insertion depths limit head
5 exposed closer drag wires
Fig. 5 is placed to the short sheath with haemostatic valve of Endovascular through skin；
1 lumen of vessels
2 short sheath menses tube walls enter at lumen of vessels
3 skins
4 short sheaths enter place in vivo through skin
5 short sheath tube bodies
The 6 short sheath connectors with haemostatic valve
Fig. 6 is sent into the closing disk and conveyer tube body of front end through short sheath haemostatic valve；
1 lumen of vessels
2 short sheath menses tube walls enter at lumen of vessels
3 skins
4 short sheaths enter place in vivo through skin
The closer delivery pipe body of 5 short sheath tube bodies and Qi Nei insertion
The 6 short sheath connectors with haemostatic valve
7 closer conveyer tube bodies
8 closer insertion depths limit head
9 exposed closer drag wires
Fig. 7 pushes closer delivery pipe, until depth limits head at short sheath connector haemostatic valve, closer disk at this time
It is automatically springed open in Endovascular；
1 lumen of vessels
2 short sheath menses tube walls enter at lumen of vessels
3 skins
4 short sheaths enter place in vivo through skin
The closer delivery pipe body of 5 short sheath tube bodies and Qi Nei insertion
The 6 short sheath connectors with haemostatic valve
7 closer insertion depths limit head
8 exposed closer drag wires
9 in the automatically rebounding open closer disk of Endovascular
Fig. 8 unscrews delivery pipe positioning head, and short sheath and closer delivery pipe are extracted together, draw drag wire outward, until
This, closer disk is close to the inner wall of vascular puncture mouth, and when pulling out drag wire outside, hangnail discharges out of delivery pipe and becomes fixed and close
The outer fixture of the blood vessel of device；
1 lumen of vessels
2 short sheath menses tube walls enter at lumen of vessels
3 skins
4 short sheaths enter place in vivo through skin
5 exposed closer drag wires
6 closer disks are close to the blood vessel at puncture orifice
Hangnail on 7 drag wires is fixed in the outer subcutaneous tissue of blood vessel
Fig. 9 mentions drag wire outside, and the light skin pressed around drag wire cuts off and exposes extracutaneous drag wire, bandage covering
Point of puncture skin.
1 is closed the closed vascular puncture mouth of device
Fixation hangnail in 2 subcutaneous tissues
The bandage of 3 skin surfaces covering puncture orifice
The foregoing is merely the preferred embodiment of the present invention, are not intended to limit the scope of the invention, all benefits
The equivalent structure or equivalent flow shift made by description of the invention and accompanying drawing content is applied directly or indirectly in other phases
The technical field of pass, is included within the scope of the present invention.
Claims (6)
1. a kind of outspoken fast closer of the vascular puncture of degradable in vivo, it is characterised in that: the vascular puncture mouth closer includes
Closer, drag wire, the hangnail being attached on drag wire, delivery conduit (Fig. 3)；
The puncture orifice closer external member includes closer disk (1), hangnail (2), delivery pipe (3), delivery pipe positioning head (4) drawing
Line (5).Described, the front end of drag wire (5) tail end from the delivery conduit (3), which is inserted into and is pulled to hangnail, fully enters delivery pipe
When stop, as shown in Figure 3.
The closer disk of the closer is passed through into the haemostatic valve insertion positioned at endovascular short sheath, then passes through closer delivery pipe
Haemostatic valve push, until closer delivery pipe positioning head approaches the haemostatic valve of short sheath, closer disk is beaten automatically in the blood vessels at this time
It is split into plate-like.Delivery pipe positioning head is unclamped, after short sheath is exited blood vessel together together with delivery pipe, to external traction drag wire, and
It gently presses to wear the skin around thorn drag wire downwards while drawing drag wire, pulls hangnail line outward closer disk solid
It is fixed.Extracutaneous drag wire is cut, vascular puncture mouth closing course is terminated.
2. the outspoken fast closer of the vascular puncture of degradable in vivo according to claim 1 is by degradable in vivo material system
Make, including closer disk, hangnail and drag wire.It is characterized in that: closer disk is by skeleton part and high-pressure electrostatic micro-nano electrospinning
Overlay film composition.
3. the outspoken fast closer of the vascular puncture of degradable in vivo according to claim 1, it is characterized in that: being close to closer
Have on the drag wire of disk and plays the hangnail that closer disk is drawn to fixed function to outside blood vessel.
4. the outspoken fast closer of the vascular puncture of degradable in vivo according to claim 1, it is characterized in that: being led when assembly
Bracing wire tail end is inserted into from delivery pipe front end, is pressed into hangnail in delivery pipe, closer disk is located at except delivery pipe front end.
5. the outspoken fast closer of the vascular puncture of degradable in vivo according to claim 1, it is characterized in that: delivery pipe is determined
Potential head is can be by the length and tightness of rotation adjustment drag wire.
6. the outspoken fast closer of the vascular puncture of degradable in vivo according to claim 1, it is characterized in that: in use, first
Closer disk is passed through into the haemostatic valve insertion positioned at endovascular short sheath, is then inserted into delivery pipe until positioning head connecing against short sheath
At head.Closer disk is opened in the blood vessels automatically at this time, unclamps the positioning head in delivery pipe, and short sheath is extracted together with delivery pipe,
Traction drag wire can be realized closure vascular puncture mouth and by the hangnail on drag wire outward, turns off device disk and is fixed on blood vessel
On inner wall.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810212662.3A CN110269658A (en) | 2018-03-15 | 2018-03-15 | A kind of outspoken fast closer of vascular puncture of degradable in vivo and its operating method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810212662.3A CN110269658A (en) | 2018-03-15 | 2018-03-15 | A kind of outspoken fast closer of vascular puncture of degradable in vivo and its operating method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN110269658A true CN110269658A (en) | 2019-09-24 |
Family
ID=67958450
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810212662.3A Pending CN110269658A (en) | 2018-03-15 | 2018-03-15 | A kind of outspoken fast closer of vascular puncture of degradable in vivo and its operating method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN110269658A (en) |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0788114A (en) * | 1993-09-22 | 1995-04-04 | Igaki Iryo Sekkei:Kk | Pricking section closing material |
| US20070083231A1 (en) * | 2005-10-07 | 2007-04-12 | Benjamin Lee | Vascular closure |
| CN101384220A (en) * | 2005-12-22 | 2009-03-11 | 科迪斯公司 | Systems and methods for closing a vessel wound |
| CN101897606A (en) * | 2005-12-23 | 2010-12-01 | 科迪斯公司 | The system that is used for closed vascular wound |
| CN105433990A (en) * | 2015-12-07 | 2016-03-30 | 张凌云 | Human pathological or iatrogenic cavity blocking device |
| CN105496480A (en) * | 2016-01-21 | 2016-04-20 | 深圳麦普奇医疗科技有限公司 | Blood vessel puncture site closer and operation method thereof |
| CN206761720U (en) * | 2016-12-20 | 2017-12-19 | 兰州大学 | A kind of absorbable tissue closes fixator |
-
2018
- 2018-03-15 CN CN201810212662.3A patent/CN110269658A/en active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0788114A (en) * | 1993-09-22 | 1995-04-04 | Igaki Iryo Sekkei:Kk | Pricking section closing material |
| US20070083231A1 (en) * | 2005-10-07 | 2007-04-12 | Benjamin Lee | Vascular closure |
| CN101384220A (en) * | 2005-12-22 | 2009-03-11 | 科迪斯公司 | Systems and methods for closing a vessel wound |
| CN101897606A (en) * | 2005-12-23 | 2010-12-01 | 科迪斯公司 | The system that is used for closed vascular wound |
| CN105433990A (en) * | 2015-12-07 | 2016-03-30 | 张凌云 | Human pathological or iatrogenic cavity blocking device |
| CN105496480A (en) * | 2016-01-21 | 2016-04-20 | 深圳麦普奇医疗科技有限公司 | Blood vessel puncture site closer and operation method thereof |
| CN206761720U (en) * | 2016-12-20 | 2017-12-19 | 兰州大学 | A kind of absorbable tissue closes fixator |
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| PB01 | Publication | ||
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Application publication date: 20190924 |