CN110256980B

CN110256980B - Antibacterial polyurethane flexible foam adhesive material for preventing pressure sores of infants and preparation method thereof

Info

Publication number: CN110256980B
Application number: CN201910534539.8A
Authority: CN
Inventors: 管亚飞; 张振兴; 许云仙; 郭丽敏; 周明柱
Original assignee: Suqian Advanced Materials Institute Of Nanjing Tech University; Jiangsu Province Hospital
Current assignee: Suqian Advanced Materials Institute Of Nanjing Tech University; Jiangsu Province Hospital
Priority date: 2019-06-20
Filing date: 2019-06-20
Publication date: 2021-09-17
Anticipated expiration: 2039-06-20
Also published as: CN110256980A

Abstract

The invention discloses an antibacterial polyurethane soft foam adhesive material for preventing pressure sores of infants, which takes polyurethane soft foam as a base material, coats a layer of low-adhesion acrylate emulsion pressure-sensitive adhesive on the surface, and is used for a disposable spacer at the contact part of hard objects such as pipelines, nasal plugs, nasal masks and the like and skin, thereby solving the problems and the defects in the prior art. The antibacterial polyurethane soft foam adhesive material for preventing pressure sores of infants has an inner-layer structure and an outer-layer structure, wherein the inner layer, namely a skin contact layer, is emulsion type acrylate pressure-sensitive adhesive, and the outer layer is a polyurethane soft foam antibacterial material.

Description

Antibacterial polyurethane flexible foam adhesive material for preventing pressure sores of infants and preparation method thereof

Technical Field

The invention relates to a polyurethane flexible foam adhesive material and a preparation method thereof, in particular to an antibacterial polyurethane flexible foam adhesive material for preventing pressure sores of infants and a preparation method thereof.

Background

When the polyurethane material is placed or used for a long time, bacteria and fungi are easy to propagate and grow due to proper environmental temperature and humidity, and the soft section part of the polyurethane is easy to be catalyzed and degraded by the bacteria, so that the product quality is reduced. The use of antibacterial agents is effective in reducing bacterial growth. There are many types of antibacterial agents, including two broad classes of antibacterial agents, including sterile antibacterial agents and organic antibacterial agents. The inorganic antibacterial agent mainly utilizes the antibacterial capability of metal, wherein the inorganic antibacterial agent has better antibacterial effect and higher cost and is a silver-based antibacterial agent. The copolymerization of organic antibacterial agents into polyurethane materials is commonly used to achieve a long lasting antibacterial effect. For example, patent publication No. CN101880371B describes a method for preparing an antibacterial polyurethane by adding 500-10000ppm of an organic quaternary ammonium salt having antibacterial activity in the prepolymerization stage. The grant publication No. CN 103420868B describes the preparation of aqueous non-toxic antibacterial polyurethane emulsion containing diquaternary ammonium salt diamine or diol monomer. In addition, it is also common that the antibacterial agent is of an inorganic/organic composite type. For example, chinese patent publication No. CN 102454107B describes a polyurethane synthetic leather material with antibacterial and antifungal functions, i.e. a composite antibacterial agent is used. The leather material has the functions of instant, efficient and lasting antibiosis and mildew resistance, has good inhibition and killing effects on staphylococcus aureus, klebsiella pneumoniae, escherichia coli, mixed mildew and the like, and has the antibiosis rate of more than 99%. Chinese patent No. CN 104193950B, granted publication number, describes a nano-antibacterial polyurethane composition, which is compounded by adopting various additives such as modified inorganic nano-antibacterial agent and mildew-proof additive.

The polyurethane soft foam material is a functional polymer material with wide application at present, and is applied to medical dressing, automobile seat cushion filling, sofa filling, water absorbing materials and the like. Application publication No. CN 107459811A discloses an antibacterial polyurethane foam, a preparation method and application thereof, aims to provide an antibacterial polyurethane foam which can be used as a positioning pad, and belongs to the technical field of antibacterial material medical treatment. The preparation temperature of polyurethane foam is normal temperature, and no irritant gas is produced in the foaming process, for example, the polyurethane foam is prepared into a radiotherapy positioning foam pad, so that the fixing effect is good, and the use comfort of a patient is good.

In the pediatric diagnosis and treatment process, some medical instruments, such as ventilation pipelines for a respirator, or other diagnosis and treatment instruments are mostly arranged on the body of an infant through hard plastic tubes, such as the nasal wings, the cheeks, the forehead and other parts, and the pressure of the instruments in the long-time treatment process is easy to damage tender skin of the infant, so that pressure sores and infection are caused, and the later aesthetic hazards are brought, and some of the hazards even life threats are brought. The gauze, the polymer soft foam and other pad are not easy to be fixed and are easy to fall off due to the self-movement of the infant. Although the antibacterial polyurethane foam is used as a positioning pad and has a certain effect on the radiotherapy fixation of adults, in the face of infants without self-control capability, a non-toxic and harmless adhesive surface adhesion layer needs to be added on the surface of the polyurethane foam to improve the adhesive force, and meanwhile, after the antibacterial polyurethane foam is used, the adhesive layer is easy to be debonded from the skin surface of the infant, so that secondary damage is avoided.

In summary, there is a need for a multifunctional polyurethane flexible foam material for reducing pressure sores and infections in infants caused by long-term medical equipment pressure in the field of infants.

Disclosure of Invention

The invention aims to solve the problems and the defects in the prior art and provides an antibacterial polyurethane soft foam adhesive material for preventing pressure sores of infants.

The invention is realized by the following technical scheme:

the antibacterial polyurethane soft foam adhesive material for preventing pressure sores of infants has an inner-layer structure and an outer-layer structure, wherein the inner layer, namely a skin contact layer, is emulsion type acrylate pressure-sensitive adhesive, and the outer layer is a polyurethane soft foam antibacterial material.

The invention further adopts the technical scheme that the antibacterial polyurethane flexible foam adhesive material for preventing pressure sores for infants is prepared from the following components in parts by weight through a low-temperature foaming process:

the antibacterial polyurethane flexible foam adhesive material for preventing pressure sores of infants has the further technical scheme that the antibacterial agent is an organic antibacterial agent, an inorganic antibacterial agent or a combination of the organic antibacterial agent and the inorganic antibacterial agent, wherein the weight ratio of the inorganic antibacterial agent to the organic antibacterial agent is preferably 1: 1-4: 3; the organic antibacterial agent is preferably elemi ester, chitin or Chinese juniper oil; the inorganic antibacterial agent is preferably titanium dioxide, Chalcanthitum or Realgar.

The invention further discloses the technical scheme of the antibacterial polyurethane flexible foam adhesive material for preventing pressure sores for infants, wherein the polyether polyol is medium-long chain type polyol with the molecular weight of 500-2000; the polyisocyanate is toluene diisocyanate, diphenylmethane diisocyanate or isophorone diisocyanate.

According to the antibacterial polyurethane flexible foam adhesive material for preventing pressure sores for infants, a further technical scheme is that the molecular weight of polyether polyol is 1000; the polyisocyanate is isophorone diisocyanate.

In the preparation of the antibacterial polyurethane soft foam adhesive material for preventing pressure sores for infants, the further technical scheme can be that the catalyst is an organic tin catalyst, preferably monobutyl organotin or dibutyl organotin; the foaming agent is preferably distilled water; the foam stabilizer is preferably a soft foam silicone oil or lauryl alcohol.

The invention further adopts the technical scheme that the emulsion type acrylate pressure-sensitive adhesive is prepared by emulsion polymerization of the following components in parts by weight:

butyl Acrylate (BA)100 parts

5-15 parts of Methyl Methacrylate (MMA)

2-5 parts of hydroxyethyl acrylate (HEMA)

100 portions of deionized water

0.2 to 0.5 portion of initiator

2.0 to 3.5 portions of emulsifier

0.1-0.3 part of buffering agent;

wherein the initial adhesion of the emulsion type acrylate pressure-sensitive adhesive is No. 13-17 balls, the permanent adhesion strength is characterized by T-type peel strength test, and the size of the emulsion type acrylate pressure-sensitive adhesive is 0.02-0.05 MPa.

The antibacterial polyurethane flexible foam adhesive material for preventing pressure sores for infants has the further technical scheme that the emulsifier is composed of one or a combination of surfactants such as sodium dodecyl benzene sulfonate, sodium dodecyl sulfate and tween 60 and a reactive emulsifier, wherein the molar ratio of the surfactant to the reactive emulsifier is 1: 1-1: 3; the initial adhesion of the emulsion acrylate pressure-sensitive adhesive is No. 15 ball. The further technical proposal is that the reactive emulsifier is polyoxyethylene ether emulsifier.

The invention further adopts the technical scheme that the initiator is one of ammonium persulfate, potassium persulfate or sodium persulfate; the buffer is sodium carbonate or sodium bicarbonate. .

The preparation method of the antibacterial polyurethane flexible foam adhesive material for preventing pressure sores for infants is characterized by comprising the following steps of:

preparing and cutting a polyurethane soft foam: adding dry polyether polyol into a three-neck flask, sealing the rest bottle openings, putting into an oil bath kettle, setting the temperature at 60-80 ℃, and stirring for 1-2 h; after the temperature is stable, adding polyisocyanate, and adding a catalyst, a foam stabilizer and an antibacterial agent 15min before stirring; after the preparation of the prepolymer is finished, pouring the prepolymer into a beaker prepared in advance, placing the beaker in a high-speed stirrer for stirring, slowly increasing the speed, adding a foaming agent when the rotating speed reaches 1200r/min, moving the high-speed stirrer away after 4-5 s, pouring liquid into a mold, and waiting for foaming and forming; cutting the foamed polyurethane block through a wire saw to prepare a foam sheet;

preparing the emulsion pressure-sensitive adhesive: adding deionized water and an emulsifier into a round-bottom flask, and quickly stirring to fully dissolve the emulsifier; mixing the monomers, and slowly adding the monomer mixture into an emulsion system by using a constant-pressure dropping funnel to prepare a pre-emulsion; stirring the pre-emulsion system for at least 30min, and preparing for use; accurately weighing an initiator, fully dissolving the initiator in deionized water, and preparing an initiator solution system for later use; adding deionized water, an emulsifier homogeneous solution and a buffer into a reactor, and adding an initiator, water and a monomer mixture to form seed latex after the temperature is raised to 70 ℃; raising the temperature of the system to 83 +/-2 ℃, and continuously polymerizing the seed emulsion for 30 min; then, slowly adding the pre-emulsion and the initiation stock solution into the reactor respectively by using two constant pressure funnels; the feeding time of the pre-emulsion and the initiation solution system is 2-3h and 3-4h respectively; after the end of the addition, the reaction system requires an additional hour to increase the conversion of the monomers; the emulsion system was then cooled to room temperature. And measuring the conversion rate and adjusting the solid content, and storing for later use.

The preparation method of the antibacterial polyurethane flexible foam adhesive material for preventing pressure sores of infants comprises the following steps: firstly, uniformly dripping emulsion pressure-sensitive adhesive on the surface of release paper by a wire bar coater, controlling the thickness of the adhesive layer to be 15-25 microns, after moisture volatilizes, placing the release paper adhesive film in a baking oven at 90-110 ℃ for heating and baking for 1-2 hours to remove unreacted monomers and unvaporized moisture, then cutting the release paper into proper size, and adhering the size to the surface of a square polyurethane soft foam sheet with the same area to prepare the antibacterial polyurethane soft foam adhesive material for preventing pressure sores of infants.

Compared with the prior art, the invention has the following beneficial effects:

the invention solves a key application requirement of a newborn diagnosis and treatment stage, can avoid secondary damage by regulating and controlling a formula to optimize the bonding strength in contact with the skin of a newborn, and the polyurethane soft foam obtains good antibacterial effect through an inorganic and organic hybrid antibacterial agent, wherein the inorganic antibacterial agent is nontoxic and harmless, and the organic antibacterial agent is a biological source, thereby ensuring the safety of the using stage.

Detailed description of the invention

The present invention will be described below with reference to specific examples, but the present invention is not limited to these examples.

Example 1

Polyether polyol with the molecular weight of 1000g/mol is opened and put into a vacuum drying oven for drying for 2 hours, and the temperature is set as 110 ℃. After drying, 100 parts of polyether polyol is weighed into a three-neck flask, a stirring paddle is inserted, the other bottle mouths are sealed, and the three-neck flask is placed into an oil bath pot (the temperature is set to 70 ℃) and stirred for 2 hours. After the temperature is stable, 40 parts of toluene diisocyanate are added, and 0.25 part of catalyst, 0.12 part of soft foam silicone oil, 0.3 part of titanium dioxide and 0.1 part of elemi-cro are added 15min before the stirring is finished. And after the preparation of the prepolymer is finished, pouring the prepolymer into a beaker prepared in advance, placing the beaker in a high-speed stirrer for stirring, slowly increasing the speed, adding 60 parts of distilled water when the rotating speed reaches 1200r/min, moving the high-speed stirrer away after 4-5 s, pouring the liquid into a mold, and waiting for foaming and forming for 8 hours. The foam-formed polyurethane blocks were then cut by wire saw to produce square foam sheets forming 50 x 50mm x 2 mm. The slices were soaked in E.coli reagent solution cultured in lactose fermentation medium for 7 days, and no obvious mildew spot was found.

20 parts of deionized water and 0.2 part of the emulsifier SR-10 are placed in a 150ml round bottom flask and stirred rapidly to dissolve the emulsifier sufficiently. The monomers were mixed and then the monomer mixture, 100 parts BA, 10 parts MMA and 4 parts HEMA, was slowly added to the emulsion system using an isopiestic dropping funnel for about 20min to prepare a pre-emulsion. The pre-emulsion system is stirred for at least 30min and is ready for use. 0.1 part of APS was accurately weighed, and sufficiently dissolved in 40 parts of deionized water to prepare an initiation solution system for use. 40 parts of deionized water, 0.1 part of SR-10 homogeneous solution and 0.1 part of sodium bicarbonate were added to the reactor, and after the temperature was raised to 70 ℃, 0.05 part of APS and 2 parts of water and a monomer mixture (containing 5 parts of BA and 0.6 part of MMA) were added to form a seed latex. The temperature of the system was raised to 83. + -. 2 ℃ and the seed emulsion polymerization was continued for 30 min. Immediately, the pre-emulsion and the priming stock solution were each added slowly to the reactor using two constant pressure funnels. The feed time for the pre-emulsion and initiation solution systems were 3h and 3.5h, respectively. After the end of the addition, the reaction system required an additional hour to increase the conversion of the monomer. The emulsion system was then cooled to room temperature. The conversion and solids content were tested to 49.5% and the emulsion pressure sensitive adhesive was stored for future use. As a result of the molecular weight measurement, the number average molecular weight was 7.89 ten thousand, the weight average molecular weight was 40.79 ten thousand, and the distribution width index was 5.16.

The pressure-sensitive adhesive is coated on the surface of a PET film and is subjected to initial adhesion and 180-degree adhesion performance test, the specific data is initial adhesion of No. 8 balls, and 180-degree peel strength is 4.2N/25 mm.

Firstly, uniformly dripping emulsion pressure-sensitive adhesive on the surface of release paper by a wire bar coater, controlling the thickness of the adhesive layer to be 20 microns, after moisture volatilizes, placing the release paper adhesive film in a 100 ℃ oven for heating and baking for 1 hour to remove a very small amount of unreacted monomers and unvaporized moisture, then cutting the release paper into the size of 50mm, and pressurizing and adhering the release paper to the surface of a square polyurethane soft foam sheet with the same area to prepare and form the double-layer composite of the polyurethane soft foam and the pressure-sensitive adhesive.

The cushion layer is lightly adhered to the skin surface of the infant, and the pressing operation is carried out. After 30 minutes, the adhesive force is strong, a small amount of reddish blood appears on the skin surface of the infant due to slight tearing, and the adhesive force fades after about 10 minutes, and no impression appears on the skin surface of the infant.

Example 2

Polyether polyol with the molecular weight of 2000g/mol is opened and put into a vacuum drying oven for drying for 2 hours, and the temperature is set as 110 ℃. And (3) after drying, putting 100 parts of polyether polyol into a three-neck flask, inserting a stirring paddle, sealing the rest bottle mouths, putting into an oil bath pot (the temperature is set to 70 ℃), and stirring for 2 hours. After the temperature is stable, 45 parts of toluene diisocyanate are added, and 0.3 part of catalyst organotin, 0.2 part of defoaming agent soft foam silicone oil and 0.4 part of inorganic antibacterial agent titanium dioxide are added 15min before stirring is finished. After the preparation of the prepolymer is finished, pouring the prepolymer into a beaker prepared in advance, placing the beaker in a high-speed stirrer for stirring, slowly increasing the speed, adding 50 parts of distilled water when the rotating speed reaches 1200r/min, moving the high-speed stirrer away after 4-5 s, pouring the liquid into a mold, and waiting for foaming and forming for 8 hours; the foamed polyurethane block was cut by a wire saw. The slices were soaked in E.coli reagent solution cultured in lactose fermentation medium for 7 days, and no obvious mildew spot was found.

The emulsion pressure sensitive adhesive was prepared as in example 1.

The wire bar coater was used to apply and bake the emulsion pressure sensitive adhesive in the same manner as in example 1, and the emulsion pressure sensitive adhesive was pressure-adhered to the surface of a square polyurethane flexible foam sheet having the same area by release paper to prepare a double-layer composite of polyurethane flexible foam and pressure sensitive adhesive.

Example 3

3000g/mol of polyether polyol are opened and put into a vacuum drying oven for drying for 2 hours, and the temperature is set as 110 ℃. And (3) after drying, putting 100 parts of polyether polyol into a three-neck flask, inserting a stirring paddle, sealing the rest bottle mouths, putting into an oil bath pot (the temperature is set to 70 ℃), and stirring for 2 hours. After the temperature is stable, 40 parts of toluene diisocyanate are added, and 0.23 part of catalyst organotin, 0.2 part of defoaming agent soft foam silicone oil and 0.3 part of elemi grease are added 15min before stirring. After the preparation of the prepolymer is finished, pouring the prepolymer into a beaker prepared in advance, placing the beaker in a high-speed stirrer for stirring, slowly increasing the speed, adding 65 parts of distilled water when the rotating speed reaches 1200r/min, moving the high-speed stirrer away after 4-5 s, pouring the liquid into a mold, and waiting for foaming and forming; the foamed polyurethane block was cut by wire saw to prepare a square foam sheet of 50 x 50mm x 2 mm. The slices were soaked in E.coli reagent solution cultured in lactose fermentation medium for 7 days, and no obvious mildew spot was found.

The emulsion pressure sensitive adhesive was prepared as in example 1.

Example 4

The preparation method of the polyurethane soft foam is the same as the embodiment 1.

The basic method and process for preparing the emulsion pressure-sensitive adhesive are the same as in example 1, but the amount of the initiator APS is increased to 0.2 part. The initial adhesion strength is improved to 13 balls, and the 180-degree peel strength is 2.8N/25 mm.

Example 5

The basic method and process for preparing the emulsion pressure-sensitive adhesive are the same as in example 1, but the amount of the initiator APS is increased to 0.3 part. The initial adhesion strength is improved to a No. 15 ball, and the 180-degree peel strength is 2.3N/25 mm.

Example 6

To a 150ml round bottom flask was added 10 parts deionized water along with 1.2 parts emulsifier SR-10 and 1.2 parts sodium dodecylbenzenesulfonate, with rapid agitation, to dissolve the emulsifier thoroughly. The reaction and feed quality were as in example 1, the conversion and solids content were measured to be 48.1% wt, and the emulsion pressure sensitive adhesive was stored for future use.

The pressure-sensitive adhesive is coated on the surface of a PET film and is subjected to initial adhesion and permanent adhesion performance tests, and the specific data is that the initial adhesion No. 14 ball is obtained, and the permanent adhesion strength is 2.9N/25 mm.

The cushion layer is lightly adhered to the skin surface of the infant, and the pressing operation is carried out. After 30 minutes, no redness or pressure marks were observed on the skin surface of the infant after gentle peeling.

Comparative example 1

Polyether polyol with the molecular weight of 1000g/mol is opened and put into a vacuum drying oven for drying for 2 hours, and the temperature is set as 110 ℃. After drying, 100 parts of polyether polyol is weighed into a three-neck flask, a stirring paddle is inserted, the other bottle mouths are sealed, and the three-neck flask is placed into an oil bath pot (the temperature is set to 70 ℃) and stirred for 2 hours. After the temperature is stable, 40 parts of toluene diisocyanate are added, and 0.25 part of catalyst, 0.12 part of soft foam silicone oil and no antibacterial agent are added 15min before the stirring is finished. And after the preparation of the prepolymer is finished, pouring the prepolymer into a beaker prepared in advance, placing the beaker in a high-speed stirrer for stirring, slowly increasing the speed, adding 60 parts of distilled water when the rotating speed reaches 1200r/min, moving the high-speed stirrer away after 4-5 s, pouring the liquid into a mold, and waiting for foaming and forming for 8 hours. The foam-formed polyurethane blocks were then cut by wire saw to produce square foam sheets forming 50 x 50mm x 2 mm. The slices were immersed in a reagent solution of Escherichia coli cultured in a lactose fermentation medium for 7 days, and significant mildew spots were found.

TABLE 1 bonding data and Peel conditions for emulsion pressure sensitive adhesives of examples 1-6

Sample (I)	Initial viscosity (ball)	Permanent bonding strength N/25mm
			Example 1	8	4.2
Example 4	13	2.8
			Example 5	15	2.3
Example 6	14	2.9

Claims

1. The utility model provides an infant prevents pressing sore and adheres material with antibiotic polyurethane soft bubble which characterized in that: the material has an inner layer structure and an outer layer structure, wherein the inner layer, namely a skin contact layer, is emulsion type acrylate pressure-sensitive adhesive, and the outer layer is a polyurethane soft foam antibacterial material; the polyurethane soft foam antibacterial material is prepared from the following components in parts by weight through a low-temperature foaming process:

polyether polyol 100 parts

40-50 parts of polyisocyanate

50-70 parts of foaming agent

0.2 to 0.4 portion of catalyst

0.02-0.3 part of foam stabilizer

0.1-0.9 parts of antibacterial agent;

the emulsion type acrylate pressure-sensitive adhesive is prepared by emulsion polymerization of the following components in parts by weight:

butyl acrylate 100 parts

5-15 parts of methyl methacrylate

2-5 parts of hydroxyethyl acrylate

100 portions of deionized water

0.2 to 0.5 portion of initiator

2.0 to 3.5 portions of emulsifier

0.1-0.3 part of buffering agent;

wherein the initial adhesion of the emulsion type acrylate pressure-sensitive adhesive is No. 13-17 ball, the permanent adhesion strength is characterized by T-type peel strength test, and the size of the permanent adhesion strength is 0.02-0.05 Mpa; the emulsifier is composed of a surfactant and a reactive emulsifier, the molar ratio of the surfactant to the reactive emulsifier is 1: 1-1: 3, and the reactive emulsifier is a polyoxyethylene ether emulsifier SR-10.

2. The antibacterial polyurethane flexible foam adhesive material for preventing pressure sores of infants according to claim 1, wherein the antibacterial agent is an organic antibacterial agent, an inorganic antibacterial agent or a combination of the organic antibacterial agent and the inorganic antibacterial agent, wherein the weight ratio of the inorganic antibacterial agent to the organic antibacterial agent is 1: 1-4: 3.

3. The antibacterial polyurethane flexible foam adhesive material for preventing pressure sores for infants according to claim 1, wherein the polyether polyol is a medium-long chain polyol with molecular weight of 500-2000; the polyisocyanate is toluene diisocyanate, diphenylmethane diisocyanate or isophorone diisocyanate.

4. The antibacterial polyurethane flexible foam adhesive material for preventing pressure sores for infants according to claim 1, wherein the catalyst is an organotin catalyst; the foaming agent is distilled water; the foam stabilizer is soft foam silicone oil or lauryl alcohol.

5. The antibacterial polyurethane flexible foam adhesive material for preventing pressure sores for infants according to claim 1, wherein the surfactant is one or a combination of sodium dodecyl benzene sulfonate, sodium dodecyl sulfate and tween 60; the initial adhesion of the emulsion type acrylate pressure-sensitive adhesive is a No. 15 ball.

6. The antibacterial polyurethane flexible foam adhesive material for preventing pressure sores for infants according to claim 1, wherein the initiator is one of ammonium persulfate, potassium persulfate or sodium persulfate; the buffer is sodium carbonate or sodium bicarbonate.

7. A method for preparing the antibacterial polyurethane flexible foam adhesive material for preventing pressure sores for infants as claimed in any one of claims 1 to 6, which is characterized by comprising the following steps of:

preparing the emulsion pressure-sensitive adhesive: adding deionized water and an emulsifier into a round-bottom flask, and quickly stirring to fully dissolve the emulsifier; mixing the monomers, and slowly adding the monomer mixture into an emulsion system by using a constant-pressure dropping funnel to prepare a pre-emulsion; stirring the pre-emulsion system for at least 30min, and preparing for use; accurately weighing an initiator, fully dissolving the initiator in deionized water, and preparing an initiator solution system for later use; adding deionized water, an emulsifier homogeneous solution and a buffer into a reactor, and adding an initiator, water and a monomer mixture to form seed latex after the temperature is raised to 70 ℃; raising the temperature of the system to 83 +/-2 ℃, and continuously polymerizing the seed emulsion for 30 min; then, slowly adding the pre-emulsion and the initiation stock solution into the reactor respectively by using two constant pressure funnels; the feeding time of the pre-emulsion and the initiation solution system is 2-3h and 3-4h respectively; after the end of the addition, the reaction system requires an additional hour to increase the conversion of the monomers; then, cooling the emulsion system to room temperature; measuring the conversion rate and adjusting the solid content, and storing for later use;