CN110251725A - A kind of sodium alginate micro ball packing material and preparation method thereof - Google Patents
A kind of sodium alginate micro ball packing material and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/20—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
- A61L27/222—Gelatin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/06—Flowable or injectable implant compositions
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Abstract
The present invention provides a kind of sodium alginate micro ball packing material, the packing material is by including that the raw material of following parts by weight is made: 30-50 parts of sodium alginate, 5-15 parts of gelatin, 0.5-5 parts of chitosan, 0.1-3 parts of adsorbent, 5-10 parts of crosslinking agent, 100-200 parts of physiological saline.Each component has preferable biocompatibility in the invention sodium alginate micro ball packing material, it is cross-linked with each other, is effectively prevented the degradation of hyaluronic acid, and stablize in body filling plasticity, moulding effect is good, overcomes the defect that bio-toxicity is easily caused using cross-linked-hyaluronic acid.
Description
Technical field
The invention belongs to biomedicine fields, more particularly, to a kind of sodium alginate micro ball packing material and its preparation side
Method.
Background technique
Today's society, shaping have been not only the patent in injury repair field, more become people and pursue beautiful means.
With the improvement of living standards, the development of shaping technique obtains this beautiful approach by shaping and has gradually been connect by people
By and trust.The crowd for receiving shaping has also been spread via the amusement circles star for being engaged in performing career to ruck, from shaping
The great demand market that beauty treatment material is possessed, we can predict its good development prospect.
Spring bamboo after various shaping and beauty means such as rain continues to bring out, including traditional plastic surgery operations, microsurgery
Technology, Skin expansion and injection transplantation technology etc., wherein injection beauty is particularly subject to pursuing for shaping and beauty hospitalier,
The extensive approval that medical and beauty treatment industry professional and people seeking beauty are obtained in worldwide, becomes the hair of the following medical and beauty treatment
Open up direction.
Injecting beauty is that filler is injected body local, to reach the beauty method of amendment skin defect.Injection beauty
Appearance is one kind of non-operating shaping beauty, is injected biomaterial or artificial synthesized biocompatible material using the method for injection
Enter skin corium or the method for reducing a major class plastic operation of skinfold or plastotype is subcutaneously reached by the different mechanism of action.
Have the characteristics that safe, painless, efficient.
The key for injecting beauty is injection material, has collagen, hyaluronic acid etc. at present and is used for injection material.But by
In being difficult to form support, within some months, after being absorbed by organisms, figure repair disappears.Most commonly used hyaluronic acid
The important component of humans and animals skin, vitreum, joint lubrication liquid and cartilaginous tissue, it by (1- β -4) D- glucuronic acid and
(1- β -3) N- acetyl group-D- aminoglucose dissacharide units repeat be formed by connecting, be widely used in prosthesis, operated eye or
Wrinkle is filled as beauty product.Due to being degraded rapidly by the enzymolysis of hyaluronidase in vivo, such material
Material needs to be injected for a long time.In order to promote retention time, drop is mainly reduced by cross-linked-hyaluronic acid both at home and abroad at present
Solution problem.However since crosslinking agent has very high bio-toxicity, potential danger is caused to injection beauty.
In consideration of it, constantly exploring the pass that persistence is good, good biocompatibility injection material is beauty and shaping sound development
Key.
Summary of the invention
In view of this, the present invention is directed to propose a kind of sodium alginate micro ball packing material and preparation method thereof, simple process,
Condition is controllable, is used for industrialized production.
In order to achieve the above objectives, the technical scheme of the present invention is realized as follows:
A kind of sodium alginate micro ball packing material, the packing material is by including that the raw material of following parts by weight is made:
Preferably, the packing material is by including that the raw material of following parts by weight is made:
Preferably, the packing material is by including that the raw material of following parts by weight is made:
Further, the packing material further includes 10-15 parts of polylactic acid.
Further, the crosslinking agent is at least one of calcium chloride, carboxymethyl cellulose or Geniposide；The suction
Attached dose is at least one of aluminium oxide, collagen or bovine serum albumin(BSA).
The preparation method of the sodium alginate micro ball packing material, includes the following steps:
(1) by gelatin heating and melting, chitosan is added thereto, is uniformly mixed, obtains under 3000-5000rpm stirring
Premixed liquid；
(2) sodium alginate, adsorbent and crosslinking agent are dissolved in physiological saline, are uniformly mixed, obtain filling solution；
(3) premixed liquid is added in atoleine, stirring and emulsifying 5-60 minutes, obtains premix emulsion, it will
The filling solution is added in atoleine, stirring and emulsifying 5-60 minutes, is obtained filling emulsion, is then emulsified premix
Liquid is obtained after the microballoon is centrifuged, is washed by microballoon after mixing with filling emulsion up to the sodium alginate micro ball
Packing material.
Further, molecular weight of chitosan range is 5-200kD in the step (1), and deacetylation range is 50-
65%；The time of whipping step is 30-60min in the step (1).
Further, the molecular weight of sodium alginate is 3000-20000 in the step (2)；Preferably, the step
(1) molecular weight of sodium alginate is 3000-12000 in.
Further, the partial size of microballoon is 10-50 microns in the step (3).
Further, contain surfactant in atoleine in the step (3)；The surfactant is tween
80；The mass fraction of surfactant is 0.1-1.5% in the atoleine；The body of the premixed liquid and atoleine
For product than being 1:1-10, the volume ratio of the filling solution and atoleine is 1:1-10.
Further, the viscosity of the sodium alginate micro ball packing material is 150-450mPas.
Compared with the existing technology, a kind of sodium alginate micro ball packing material of the present invention and preparation method thereof have with
Lower advantage:
(1) each component has preferable biocompatibility in sodium alginate micro ball packing material of the present invention, mutually
Crosslinking is effectively prevented the degradation of hyaluronic acid, and stablizes in body filling plasticity, and moulding effect is good, overcomes using friendship
Connection hyaluronic acid easily causes the defect of bio-toxicity.
(2) the preparation method mild condition of sodium alginate micro ball packing material of the present invention, step is simple, is convenient for work
Industry metaplasia produces.
Specific embodiment
In addition to being defined, technical term used in following embodiment has universal with those skilled in the art of the invention
The identical meanings of understanding.Test reagent used in following embodiment is unless otherwise specified conventional biochemical reagent；It is described
Experimental method is unless otherwise specified conventional method.
Below with reference to embodiment, the present invention will be described in detail.
Embodiment 1
A kind of sodium alginate micro ball packing material, the packing material is by including that the raw material of following parts by weight is made: sea
32 parts of mosanom, 10 parts of gelatin, 0.6 part of chitosan, 0.2 part of carboxymethyl cellulose, 5 parts of collagen, 120 parts of physiological saline,
10 parts of polylactic acid.
The preparation method of the sodium alginate micro ball packing material, include the following steps: (1) by gelatin heating and melting,
Chitosan is added thereto, is uniformly mixed under 3000-5000rpm stirring, obtains premixed liquid；(2) by sodium alginate, adsorbent
It is dissolved in physiological saline, is uniformly mixed with crosslinking agent, obtain filling solution；(3) premixed liquid is added to and is spat containing 1%
In the atoleine of temperature 80, stirring and emulsifying 30 minutes, premix emulsion is obtained, the filling solution is added to containing 1%
In the atoleine of Tween 80, stirring and emulsifying 30 minutes, filling emulsion is obtained, it then will premix emulsion and filling emulsion
Microballoon is obtained after mixing, up to the sodium alginate micro ball packing material after the microballoon is centrifuged, is washed.
Molecular weight of chitosan range is 10-200kD in the step (1), and deacetylation range is 60-65%.It is described
The step of (3) in the volume ratio of premixed liquid and atoleine be 1:5, the volume ratio of the described filling solution and atoleine is 1:
5.The partial size of microballoon is 40-50 microns in the step (3).The molecular weight of sodium alginate is 3000- in the step (1)
5000.The viscosity of the sodium alginate micro ball packing material is 300-450mPas.
Embodiment 2
A kind of sodium alginate micro ball packing material, the packing material is by including that the raw material of following parts by weight is made: sea
32 parts of mosanom, 15 parts of gelatin, 0.6 part of chitosan, 0.2 part of carboxymethyl cellulose, 5 parts of collagen, 120 parts of physiological saline,
10 parts of polylactic acid.
The preparation method of the sodium alginate micro ball packing material, include the following steps: (1) by gelatin heating and melting,
Chitosan is added thereto, is uniformly mixed under 3000-5000rpm stirring, obtains premixed liquid；(2) by sodium alginate, adsorbent
It is dissolved in physiological saline, is uniformly mixed with crosslinking agent, obtain filling solution；(3) premixed liquid is added to and is spat containing 1%
In the atoleine of temperature 80, stirring and emulsifying 30 minutes, premix emulsion is obtained, the filling solution is added to containing 1%
In the atoleine of Tween 80, stirring and emulsifying 30 minutes, filling emulsion is obtained, it then will premix emulsion and filling emulsion
Microballoon is obtained after mixing, up to the sodium alginate micro ball packing material after the microballoon is centrifuged, is washed.
Molecular weight of chitosan range is 10-200kD in the step (1), and deacetylation range is 60-65%.It is described
The step of (3) in the volume ratio of premixed liquid and atoleine be 1:5, the volume ratio of the described filling solution and atoleine is 1:
5.The partial size of microballoon is 40-50 microns in the step (3).The molecular weight of sodium alginate is 3000- in the step (1)
5000.The viscosity of the sodium alginate micro ball packing material is 300-450mPas.
Embodiment 3
A kind of sodium alginate micro ball packing material, the packing material is by including that the raw material of following parts by weight is made: sea
32 parts of mosanom, 15 parts of gelatin, 3 parts of chitosan, 0.2 part of carboxymethyl cellulose, 5 parts of collagen, 120 parts of physiological saline, gather
10 parts of lactic acid.
The preparation method of the sodium alginate micro ball packing material, include the following steps: (1) by gelatin heating and melting,
Chitosan is added thereto, is uniformly mixed under 3000-5000rpm stirring, obtains premixed liquid；(2) by sodium alginate, adsorbent
It is dissolved in physiological saline, is uniformly mixed with crosslinking agent, obtain filling solution；(3) premixed liquid is added to and is spat containing 1%
In the atoleine of temperature 80, stirring and emulsifying 30 minutes, premix emulsion is obtained, the filling solution is added to containing 1%
In the atoleine of Tween 80, stirring and emulsifying 30 minutes, filling emulsion is obtained, it then will premix emulsion and filling emulsion
Microballoon is obtained after mixing, up to the sodium alginate micro ball packing material after the microballoon is centrifuged, is washed.
Molecular weight of chitosan range is 10-200kD in the step (1), and deacetylation range is 60-65%.It is described
The step of (3) in the volume ratio of premixed liquid and atoleine be 1:5, the volume ratio of the described filling solution and atoleine is 1:
5.The partial size of microballoon is 40-50 microns in the step (3).The molecular weight of sodium alginate is 3000- in the step (1)
5000.The viscosity of the sodium alginate micro ball packing material is 300-450mPas.
Embodiment 4
A kind of sodium alginate micro ball packing material, the packing material is by including that the raw material of following parts by weight is made: sea
32 parts of mosanom, 15 parts of gelatin, 3 parts of chitosan, 0.2 part of carboxymethyl cellulose, 5 parts of collagen, 120 parts of physiological saline, gather
15 parts of lactic acid.
The preparation method of the sodium alginate micro ball packing material, include the following steps: (1) by gelatin heating and melting,
Chitosan is added thereto, is uniformly mixed under 3000-5000rpm stirring, obtains premixed liquid；(2) by sodium alginate, adsorbent
It is dissolved in physiological saline, is uniformly mixed with crosslinking agent, obtain filling solution；(3) premixed liquid is added to and is spat containing 1%
In the atoleine of temperature 80, stirring and emulsifying 30 minutes, premix emulsion is obtained, the filling solution is added to containing 1%
In the atoleine of Tween 80, stirring and emulsifying 30 minutes, filling emulsion is obtained, it then will premix emulsion and filling emulsion
Microballoon is obtained after mixing, up to the sodium alginate micro ball packing material after the microballoon is centrifuged, is washed.
Molecular weight of chitosan range is 10-200kD in the step (1), and deacetylation range is 60-65%.It is described
The step of (3) in the volume ratio of premixed liquid and atoleine be 1:5, the volume ratio of the described filling solution and atoleine is 1:
5.The partial size of microballoon is 40-50 microns in the step (3).The molecular weight of sodium alginate is 3000- in the step (1)
5000.The viscosity of the sodium alginate micro ball packing material is 300-450mPas.
Embodiment 5
A kind of sodium alginate micro ball packing material, the packing material is by including that the raw material of following parts by weight is made: sea
42 parts of mosanom, 15 parts of gelatin, 3 parts of chitosan, 0.2 part of carboxymethyl cellulose, 5 parts of collagen, 120 parts of physiological saline, gather
15 parts of lactic acid.
The preparation method of the sodium alginate micro ball packing material, include the following steps: (1) by gelatin heating and melting,
Chitosan is added thereto, is uniformly mixed under 3000-5000rpm stirring, obtains premixed liquid；(2) by sodium alginate, adsorbent
It is dissolved in physiological saline, is uniformly mixed with crosslinking agent, obtain filling solution；(3) premixed liquid is added to and is spat containing 1%
In the atoleine of temperature 80, stirring and emulsifying 30 minutes, premix emulsion is obtained, the filling solution is added to containing 1%
In the atoleine of Tween 80, stirring and emulsifying 30 minutes, filling emulsion is obtained, it then will premix emulsion and filling emulsion
Microballoon is obtained after mixing, up to the sodium alginate micro ball packing material after the microballoon is centrifuged, is washed.
Molecular weight of chitosan range is 10-200kD in the step (1), and deacetylation range is 60-65%.It is described
The step of (3) in the volume ratio of premixed liquid and atoleine be 1:5, the volume ratio of the described filling solution and atoleine is 1:
5.The partial size of microballoon is 40-50 microns in the step (3).The molecular weight of sodium alginate is 3000- in the step (1)
5000.The viscosity of the sodium alginate micro ball packing material is 300-450mPas.
Embodiment 6
A kind of sodium alginate micro ball packing material, the packing material is by including that the raw material of following parts by weight is made: sea
42 parts of mosanom, 6 parts of gelatin, 3 parts of chitosan, 0.2 part of carboxymethyl cellulose, 5 parts of collagen, 120 parts of physiological saline, gather cream
15 parts of acid.
The preparation method of the sodium alginate micro ball packing material, include the following steps: (1) by gelatin heating and melting,
Chitosan is added thereto, is uniformly mixed under 3000-5000rpm stirring, obtains premixed liquid；(2) by sodium alginate, adsorbent
It is dissolved in physiological saline, is uniformly mixed with crosslinking agent, obtain filling solution；(3) premixed liquid is added to and is spat containing 1%
In the atoleine of temperature 80, stirring and emulsifying 30 minutes, premix emulsion is obtained, the filling solution is added to containing 1%
In the atoleine of Tween 80, stirring and emulsifying 30 minutes, filling emulsion is obtained, it then will premix emulsion and filling emulsion
Microballoon is obtained after mixing, up to the sodium alginate micro ball packing material after the microballoon is centrifuged, is washed.
Molecular weight of chitosan range is 10-200kD in the step (1), and deacetylation range is 60-65%.It is described
The step of (3) in the volume ratio of premixed liquid and atoleine be 1:5, the volume ratio of the described filling solution and atoleine is 1:
5.The partial size of microballoon is 40-50 microns in the step (3).The molecular weight of sodium alginate is 3000- in the step (1)
5000.The viscosity of the sodium alginate micro ball packing material is 300-450mPas.
Embodiment 7
A kind of sodium alginate micro ball packing material, the packing material is by including that the raw material of following parts by weight is made: sea
42 parts of mosanom, 6 parts of gelatin, 5 parts of chitosan, 0.2 part of carboxymethyl cellulose, 5 parts of collagen, 120 parts of physiological saline, gather cream
15 parts of acid.
The preparation method of the sodium alginate micro ball packing material, include the following steps: (1) by gelatin heating and melting,
Chitosan is added thereto, is uniformly mixed under 3000-5000rpm stirring, obtains premixed liquid；(2) by sodium alginate, adsorbent
It is dissolved in physiological saline, is uniformly mixed with crosslinking agent, obtain filling solution；(3) premixed liquid is added to and is spat containing 1%
In the atoleine of temperature 80, stirring and emulsifying 30 minutes, premix emulsion is obtained, the filling solution is added to containing 1%
In the atoleine of Tween 80, stirring and emulsifying 30 minutes, filling emulsion is obtained, it then will premix emulsion and filling emulsion
Microballoon is obtained after mixing, up to the sodium alginate micro ball packing material after the microballoon is centrifuged, is washed.
Molecular weight of chitosan range is 10-200kD in the step (1), and deacetylation range is 60-65%.It is described
The step of (3) in the volume ratio of premixed liquid and atoleine be 1:5, the volume ratio of the described filling solution and atoleine is 1:
5.The partial size of microballoon is 40-50 microns in the step (3).The molecular weight of sodium alginate is 3000- in the step (1)
5000.The viscosity of the sodium alginate micro ball packing material is 300-450mPas.
Sodium alginate micro ball packing material obtained in embodiment 1-7 is detected, testing result such as table 1 and table 2
It is shown.
1 external degradation result of table
| Serial number | 0 | 20 days | 80 days | 300 days |
| Embodiment 1 | 0% | 16.54% | 32.86% | 59.36% |
| Embodiment 2 | 0% | 17.23% | 33.12% | 63.15% |
| Embodiment 3 | 0% | 16.71% | 31.26% | 61.23% |
| Embodiment 4 | 0% | 16.96% | 33.02% | 64.02% |
| Embodiment 5 | 0% | 17.14% | 32.88% | 62.74% |
| Embodiment 6 | 0% | 17.78% | 31.64% | 60.78% |
| Embodiment 7 | 0% | 16.32% | 33.06% | 64.19% |
2 physicochemical property of table (80 days)
| Serial number | Viscosity (mPas) | Partial size (μm) |
| Embodiment 1 | 143.8 | 26.45 |
| Embodiment 2 | 162.4 | 31.87 |
| Embodiment 3 | 156.3 | 29.06 |
| Embodiment 4 | 150.6 | 24.66 |
| Embodiment 5 | 168.4 | 26.41 |
| Embodiment 6 | 162.4 | 28.17 |
| Embodiment 7 | 152.9 | 25.34 |
As shown in Table 1, the packing material degradation speed gradually slows down, and can maintain long-acting drug effect, can obtain in table 2
Out, with the progress of degradation, viscosity gradually decreases packing material with partial size, shows its in the stability of body filling plasticity.
The foregoing is merely illustrative of the preferred embodiments of the present invention, is not intended to limit the invention, all in essence of the invention
Within mind and principle, any modification, equivalent replacement, improvement and so on be should all be included in the protection scope of the present invention.
Claims (10)
1. a kind of sodium alginate micro ball packing material, it is characterised in that: the packing material is by the raw material system including following parts by weight
At:
2. sodium alginate micro ball packing material according to claim 1, it is characterised in that: the packing material is by including
The raw material of following parts by weight is made:
3. sodium alginate micro ball packing material according to claim 2, it is characterised in that: the packing material further includes
10-15 parts of polylactic acid.
4. sodium alginate micro ball packing material according to claim 2, it is characterised in that: the crosslinking agent is chlorination
At least one of calcium, carboxymethyl cellulose or Geniposide；The adsorbent is aluminium oxide, collagen or bovine serum albumin
It is at least one of white.
5. the preparation method of sodium alginate micro ball packing material of any of claims 1-4, it is characterised in that: including
Following steps:
(1) by gelatin heating and melting, chitosan is added thereto, is uniformly mixed, is premixed under 3000-5000rpm stirring
Liquid；
(2) sodium alginate, adsorbent and crosslinking agent are dissolved in physiological saline, are uniformly mixed, obtain filling solution；
(3) premixed liquid is added in atoleine, stirring and emulsifying 5-60 minutes, obtains premix emulsion, it will be described
Filling solution be added in atoleine, stirring and emulsifying 5-60 minutes, obtain filling emulsion, then will premix emulsion with
Microballoon is obtained after filling emulsion mixing, is filled out after the microballoon is centrifuged, is washed up to the sodium alginate micro ball
Fill material.
6. the preparation method of sodium alginate micro ball packing material according to claim 5, it is characterised in that: the step
(1) molecular weight of chitosan range is 5-200kD in, and deacetylation range is 50-65%；Whipping step in the step (1)
Time be 30-60min.
7. the preparation method of sodium alginate micro ball packing material according to claim 5, it is characterised in that: the step
(2) molecular weight of sodium alginate is 3000-20000 in；Preferably, the molecular weight of sodium alginate is in the step (1)
3000-12000。
8. the preparation method of sodium alginate micro ball packing material according to claim 5, it is characterised in that: the step
(3) partial size of microballoon is 10-50 microns in.
9. the preparation method of sodium alginate micro ball packing material according to claim 5, it is characterised in that: the step
(3) contain surfactant in atoleine；The surfactant is Tween 80；Surface is living in the atoleine
Property agent mass fraction be 0.1-1.5%；The volume ratio of the premixed liquid and atoleine is 1:1-10, and the filling is molten
The volume ratio of liquid and atoleine is 1:1-10.
10. the preparation method of sodium alginate micro ball packing material according to claim 5, it is characterised in that: the sea
The viscosity of mosanom microballoon packing material is 150-450mPas.
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| CN113289050A (en) * | 2021-05-14 | 2021-08-24 | 宁波市第一医院 | Hemostatic sponge and preparation method thereof |
| CN114887109A (en) * | 2022-05-23 | 2022-08-12 | 大连理工大学 | Self-temperature-controlled magnetic-response drug release embolism microsphere with CT/MR developing function and preparation method thereof |
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