CN110246545B - 一种序列的校正方法及其校正装置 - Google Patents
一种序列的校正方法及其校正装置 Download PDFInfo
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- CN110246545B CN110246545B CN201910493581.XA CN201910493581A CN110246545B CN 110246545 B CN110246545 B CN 110246545B CN 201910493581 A CN201910493581 A CN 201910493581A CN 110246545 B CN110246545 B CN 110246545B
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- 238000012937 correction Methods 0.000 title claims abstract description 179
- 238000000034 method Methods 0.000 title claims abstract description 79
- 239000012634 fragment Substances 0.000 claims abstract description 184
- 238000012163 sequencing technique Methods 0.000 claims description 107
- 238000004364 calculation method Methods 0.000 claims description 20
- 238000012217 deletion Methods 0.000 claims description 7
- 230000037430 deletion Effects 0.000 claims description 7
- 238000001914 filtration Methods 0.000 claims description 6
- 238000007781 pre-processing Methods 0.000 claims description 4
- 238000012790 confirmation Methods 0.000 claims description 3
- 238000002864 sequence alignment Methods 0.000 claims description 3
- 238000005192 partition Methods 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 abstract description 8
- 238000007671 third-generation sequencing Methods 0.000 description 13
- 230000000694 effects Effects 0.000 description 10
- 238000005516 engineering process Methods 0.000 description 7
- 241000219195 Arabidopsis thaliana Species 0.000 description 6
- 238000012545 processing Methods 0.000 description 5
- 238000012795 verification Methods 0.000 description 4
- YLZOPXRUQYQQID-UHFFFAOYSA-N 3-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)-1-[4-[2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidin-5-yl]piperazin-1-yl]propan-1-one Chemical compound N1N=NC=2CN(CCC=21)CCC(=O)N1CCN(CC1)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F YLZOPXRUQYQQID-UHFFFAOYSA-N 0.000 description 2
- 238000004891 communication Methods 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 241000219194 Arabidopsis Species 0.000 description 1
- 238000001712 DNA sequencing Methods 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 241000282414 Homo sapiens Species 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000002372 labelling Methods 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 238000000638 solvent extraction Methods 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
Classifications
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- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
- G16B20/30—Detection of binding sites or motifs
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- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
- G16B30/10—Sequence alignment; Homology search
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- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
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- General Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Computational Biology (AREA)
- Biotechnology (AREA)
- Evolutionary Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medical Informatics (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Theoretical Computer Science (AREA)
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Families Citing this family (2)
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CN111477276B (zh) * | 2020-04-02 | 2020-12-15 | 上海之江生物科技股份有限公司 | 微生物的种特异共有序列的获得方法、装置及应用 |
CN114520024B (zh) * | 2022-01-17 | 2024-03-22 | 浙江天科高新技术发展有限公司 | 一种基于k-mer的序列联配方法 |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105574361A (zh) * | 2015-11-05 | 2016-05-11 | 上海序康医疗科技有限公司 | 一种检测基因组拷贝数变异的方法 |
CN106874709A (zh) * | 2015-12-12 | 2017-06-20 | 北京大学 | 测序结果中序列数据错误的检测和校正方法 |
CN107229842A (zh) * | 2017-06-02 | 2017-10-03 | 肖传乐 | 一种基于局部图的三代测序序列校正方法 |
CN108573127A (zh) * | 2017-03-14 | 2018-09-25 | 深圳华大基因科技服务有限公司 | 一种核酸第三代测序原始数据的处理方法及其应用 |
CN108595915A (zh) * | 2018-04-16 | 2018-09-28 | 北京化工大学 | 一种基于dna变异检测的三代数据校正方法 |
WO2019086900A1 (en) * | 2017-11-03 | 2019-05-09 | Oxford University Innovation Limited | Computer-implemented method and system for determining a disease status of a subject from immune-receptor sequencing data |
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2019
- 2019-06-06 CN CN201910493581.XA patent/CN110246545B/zh active Active
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105574361A (zh) * | 2015-11-05 | 2016-05-11 | 上海序康医疗科技有限公司 | 一种检测基因组拷贝数变异的方法 |
CN106874709A (zh) * | 2015-12-12 | 2017-06-20 | 北京大学 | 测序结果中序列数据错误的检测和校正方法 |
CN108573127A (zh) * | 2017-03-14 | 2018-09-25 | 深圳华大基因科技服务有限公司 | 一种核酸第三代测序原始数据的处理方法及其应用 |
CN107229842A (zh) * | 2017-06-02 | 2017-10-03 | 肖传乐 | 一种基于局部图的三代测序序列校正方法 |
WO2019086900A1 (en) * | 2017-11-03 | 2019-05-09 | Oxford University Innovation Limited | Computer-implemented method and system for determining a disease status of a subject from immune-receptor sequencing data |
CN108595915A (zh) * | 2018-04-16 | 2018-09-28 | 北京化工大学 | 一种基于dna变异检测的三代数据校正方法 |
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Denomination of invention: A Sequence Correction Method and Its Correction Device Effective date of registration: 20221125 Granted publication date: 20210413 Pledgee: Pudong Shanghai Development Bank Limited by Share Ltd. Wuhan branch Pledgor: Wuhan hope group Biotechnology Co.,Ltd. Registration number: Y2022420000372 |