CN110237108A - Gotu Kola P.E nourishes the purposes in ovary tcm product in preparation - Google Patents
Gotu Kola P.E nourishes the purposes in ovary tcm product in preparation Download PDFInfo
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- CN110237108A CN110237108A CN201910656959.3A CN201910656959A CN110237108A CN 110237108 A CN110237108 A CN 110237108A CN 201910656959 A CN201910656959 A CN 201910656959A CN 110237108 A CN110237108 A CN 110237108A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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Abstract
The invention discloses Gotu Kola P.Es to nourish the application in ovary product in preparation.The present invention grows insufficient pathogenesis according to ovarian dysfunction and gonad granulocyte, make full use of natural resources of Chinese medicinal materials, on the basis of preparing Gotu Kola P.E, pass through pharmacological evaluation, Gotu Kola P.E is developed to treatment ovarian dysfunction and improves the new application in gonad granulocyte activity, the extract can be added in the tcm product of different dosage forms, the activity that ovary reaches nourishing ovary is adjusted by promoting gonad granulocyte proliferation and improving the estrogen and progestogen secretion level of gonad granulocyte, clinically for treating ovarian dysfunction, with good effect, effective component is clear, Small side effects, the advantages that easy to use.
Description
Technical field
The invention belongs to Chinese medicine medical fields, and in particular to the active Gotu Kola P.E of gonad granulocyte can be improved and exist
The new application in terms of ovary tcm product is nourished in preparation.
Background technique
The physiological function of ovary includes ovulation and endocrine function, to the reproductive function of women, physical and mental health and life matter
Measurer is significant.Ovarian dysfunction can cause ovulatory dysfunction, luteal function exception and endocrine disturbance etc., to draw
Various gynecological diseases, such as hypoplasia of uterus, infertility, premature ovarian failure, perimenopausal syndrome are played, and whole body can be influenced
The physiological function of other internal organs.
Ovary is the important reproductive organs of jenny reproductive system, have both sides important function, first is that generate at
Ripe ovum, second is that secretion steroid hormone.Granular cell is estrogen secreted by the chief functional cells and ovary of ovary,
The important synthesizing site of progestational hormone.The proliferation of granular cell and differentiation can be used as the mark of follicular development.Granular cell is mature
Maximum cell mass in ovarian follicle, the cell uniquely expressed in women body, the metabolism of egg mother cell require full by granular cell
Foot.Small molecule metabolites such as energy substrate, nucleotide and amino are absorbed from the granular cell medium of surrounding by gap connection
Acid etc..
Premature ovarian failure means that atretic follicle increases to a certain extent, and the ovarian follicle in growth is reduced.And ovarian granulosa
Cell (GC) is the important symbol of follicular development as body cell important in ovarian follicle, and the apoptosis of gonad granulocyte is being adjusted
All play the role of during control ovarian follicular growth, egg maturation and estrogen secretion highly important.
Currently, doctor trained in Western medicine is promoting gonad granulocyte proliferation, adjusts in ovarian function and rely primarily on hormone replacement, ovulation induction is controlled
The means such as treatment receive certain curative effect, but there are many side effects, and Chinese medicine has multisystem, too many levels, the whole of multiple target point to adjust
Section effect, and its few side effects, have certain advantage in terms of adjusting ovarian function.Therefore it is necessary in traditional Chinese medical theory
Guidance under develop that a kind of active principle is clear, curative for effect, Small side effects, treatment ovarian dysfunction convenient to take and
Promote gonad granulocyte activity and then nourishes the product of ovary.
Centella (Centella asiatica (L.) Urban), it is Umbelliferae perennial herb, all herbal medicine, heat-clearing
Dampness removing, subdhing swelling and detoxicating control acute diseases such as cholera and sunstroke xenon abdominal pain, heat rushes down, dysentery, jaundice with damp-heat pathogen, blood strangury, malignant boil carbuncle swells poison, traumatic injury etc..Herb is main
Containing triterpenic acid and triterpenoid saponin, there are asiatic acid, brahmic acid, different brahmic acid and birch skin acid etc..Modern pharmacology
Research finds that asiaticoside has the effects that anti-inflammatory, wound healing, prevents scar hyperplasia, and it is each to be mainly used for treatment
Kind skin injury, including wound scar, digestive tract ulcer, chorionitis etc.；In addition there are also anti-urinary system infection contamination, induction tumour are thin
The effects of born of the same parents' apoptosis.It not yet has been reported that for Gotu Kola P.E to be used to prepare at present and improves gonad granulocyte activity and then nourish
The application of ovary product.
Summary of the invention
The purpose of the present invention is explore Gotu Kola P.E to nourish the application in ovary product in preparation.
To achieve the goals above, the technical scheme adopted by the invention is as follows: centella alcohol extracting thing, the preparation of the extract
Method are as follows: take centella pulverizing medicinal materials to be sieved, 5-10 times of 70-90% ethyl alcohol is added and impregnates, 2-4 hour of circumfluence distillation extracts
The solid dry powder that liquid is concentrated under reduced pressure to give is centella alcohol extracting thing.
It is mainly to pass through the proliferation and raising ovarian granulosa that promote gonad granulocyte the present invention relates to Gotu Kola P.E
Cell estrogen and progestogen secretion level improves gonad granulocyte activity and then regulation ovarian dysfunction to reach to reach taste
Support the purpose of ovary.
The centella alcohol extract that the present invention applies can be with any one auxiliary material or drug excipient system for pharmaceutically allowing
At product, preparation can be any one dosage form pharmaceutically allowed, including but not limited to tablet, gel, cream, ball
Agent, liquid preparation, granule, electuary, soft capsule, soft capsule, pill, ointment or injection；Or as active constituent
The Chinese medical extract and common auxiliaries for adjusting ovarian function with other are at any one allowed on nourishing ovary preparation
Dosage form.Auxiliary material used can often use auxiliary material using the dosage form, compound the traditional Chinese medicine extraction of other adjusting ovarian functions used
Object (alcohol extracting thing or water extract), such as wolfberry fruit extract, angelica extract, glossy privet extract, Semen Cuscutae extract.
Beneficial effects of the present invention compared with the prior art: Gotu Kola P.E has significant increase to gonad granulocyte
The effect of growing, can significantly improve the estrogen and progestogen secretion level of gonad granulocyte and then adjusting ovarian function reaches nourishing ovary
Purpose.Therefore, Gotu Kola P.E, which can be prepared, improves the product that gonad granulocyte activity nourishes ovary, adjusts ovarian function.
The present invention provides new application for Gotu Kola P.E, expands its application range.
Specific embodiment
Effect of the present invention is described further below by way of specific embodiment:
Embodiment 1: Gotu Kola P.E is prepared
It takes centella pulverizing medicinal materials to be sieved, 8 times of 70% ethyl alcohol is added and impregnates, 2-4 hour of circumfluence distillation, extracting solution decompression is dense
The obtained solid dry powder that contracts is centella alcohol extracting thing.
Embodiment 2: Gotu Kola P.E is prepared
It takes centella pulverizing medicinal materials to be sieved, 9 times of 80% ethyl alcohol is added and impregnates, 2-4 hour of circumfluence distillation, extracting solution decompression is dense
The obtained solid dry powder that contracts is centella alcohol extracting thing.
Embodiment 3: Gotu Kola P.E is prepared
It takes centella pulverizing medicinal materials to be sieved, 10 times of 90% ethyl alcohol is added and impregnates, 2-4 hour of circumfluence distillation, extracting solution decompression is dense
The obtained solid dry powder that contracts is centella alcohol extracting thing.
Embodiment 4: activity research of the Gotu Kola P.E to gonad granulocyte
1 material
1.1 experimental material
22-27 age in days female rats, laboratory animal breeding room's room temperature (22 ± 2) DEG C, humidity 55%~65%, illumination is handed over round the clock
It replaces, well-ventilated.CO2Incubator, 0.22 μm of miillpore filter, tissue culture plate, clean work station, enzyme-linked immunosorbent assay instrument, electricity
Sub- balance, inverted biologic microscope, electric heating constant temperature sink, automatic centrifugal machine.
Pregnant mare serum gonadotrop(h)in (PMSG) (PMSG), DMEM are U.S. GIBCO Products, and calf serum (DBCS) is JRH
Biosciences Products；Dimethyl sulfoxide: Nanjing Chemistry Reagent Co., Ltd.；MTT: thiazolyl blue (MTT) by
Ultrapuregrade, Amresco packing, are configured to 50mg/LMTT solution with phosphate buffer (PBS) before use, in 4 DEG C
Refrigerator saves；Penicillin；Streptomysin；DMEM-F12 culture solution.
1.2 laboratory sample
Sample sets 1-3 is embodiment 1-3.
2 experimental methods and step
The separation and originally culture of 2.1 gonad granulocytes
It takes 22-27 age in days female rats (PMSG is subcutaneously injected in 48h in advance, and 66U/ is only), cervical dislocation after 48 h of conventinal breeding
It puts to death, the sterile bilateral ovaries for winning rat, discharges granular cell for ovary is broken, with 2mL containing penicillin and streptomysin
It dilutes in DMEM-F12 culture solution, and gently blows and beats, it is made to be dispersed into individual cells.Granular cell is collected in centrifugal filtration.
The analysis of 2.2 gonad granulocyte expanding capacities
By a certain concentration cell suspension inoculation in 24 orifice plates, every 80 μ l of hole, every 120 μ l culture solution of Kong Zaijia adjustment cell density is extremely
200 holes μ l/, every group sets 6 parallel holes.Place it in 5% CO2It is cultivated for 24 hours in incubator.Take CO224 h have been cultivated in incubator
Granular cell suspension, modeling concentration caddy and sample (2 mgmL is successively added in every hole-1), Normal group is set in parallel
(physiological saline) and model group (caddy and physiological saline).MTT solution (5 mg are added after 20 h of routine culture in every hole
mL-1) 20 μ L continue to cultivate 4 h, every hole is added three liquid of 80 μ L, is incubated overnight, and 570 nm wavelength is selected, in enzyme linked immunological
Each hole absorbance is measured on detector.Data are handled using 0 statistical software of SPSS16., comparison among groups are examined using t.P
< 0. 05 is statistically significant.
The analysis of 2.3 gonad granulocyte estrogen and progestogen secretion capacities
Sample and control group are handled with method 2.2, after being incubated overnight, (are detected female in cell suspension supernatant using radioimmunology
The content of glycol (E2) and progesterone (P).
3 experimental results and analysis
Proliferation function of 3.1 samples in vitro gonad granulocyte
For gonad granulocyte, 3 samples all have proliferation function, have for model group extremely significant sex differernce or
Significant difference (p < 0.01 or p < 0.05) illustrates that Gotu Kola P.E all has the activity for promoting gonad granulocyte proliferation.
Proliferation function (n=6) of 1 extract of table in vitro gonad granulocyte
| Group | Number of samples | OD value |
| Normal group | 6 | 0.369±0.056** |
| Model group | 6 | 0.222±0.008 |
| Sample sets 1 | 6 | 0.286±0.037* |
| Sample sets 2 | 6 | 0.288±0.041* |
| Sample sets 3 | 6 | 0.298±0.053* |
* P < 0.01 P < 0.05, * *vsModel group
The analysis of 3.2 gonad granulocyte estrogen and progestogen secretion capacities
Sample and control group handle same method, after being incubated overnight, (detect estradiol in cell suspension supernatant using radioimmunology
(E2) and the content of progesterone (P) 2, be the results are shown in Table.
Estrogen and progestogen secretion (n=3) of 2 extract of table in vitro gonad granulocyte
| Group | Estrogen (pmol/L) | Progestational hormone (nmol/L) |
| Normal group | 47536±45.7* | 13.03±0.56* |
| Model group | 46213±35.2 | 8.64±0.48 |
| Sample sets 1 | 49373±32.5** | 16.51±0.28** |
| Sample sets 2 | 48278±31.7** | 17.48±0.63** |
| Sample sets 3 | 49360±30.5** | 18.89±0. 56** |
* P < 0.01 P < 0.05, * *vsModel group
Conclusion: for gonad granulocyte, 3 samples to have improve gonad granulocyte estrogen and progestogen secretion ability,
There are extremely significant sex differernce or significant difference (p < 0.01 or p < 0.05) for model group.Illustrate that Gotu Kola P.E can
Significantly improve the secretion capacity of in vitro gonad granulocyte estrogen and progestogen.
Embodiment 5: Gotu Kola P.E emulsifiable paste
Centella alcohol extracting thing 1g, stearic acid 100g, hexadecanol 20g, glycerin monostearate 10g, white oil 10g, oxybenzene
Methyl esters 0.8g, butyl hydroxybenzoate 0.2g, glycerol 140g, potassium hydroxide 5g, ethyl alcohol 10g, distilled water add to 1000g.
Embodiment 6: Gotu Kola P.E gel
Centella alcohol extracting thing 1g, PEG400450g, hexylene glycol 80g, Tween 80 20g, carbomer 30g, ethanol amine 6ml, benzene first
Alcohol 10g, distilled water add to 1000g.
Embodiment 7: Gotu Kola P.E capsule
Centella alcohol extracting thing 100g, starch 80g, sodium carboxymethyl starch 24g, dextrin 17g, 70% appropriate amount of ethanol are made 1000
Grain (every contains Gotu Kola P.E 100mg).
Embodiment 8: Gotu Kola P.E piece
Gotu Kola P.E 1000g, lactose 55g, amylum pregelatinisatum 15g, hydroxypropylcellulose 10g, magnesium stearate 5g, 70% ethyl alcohol
In right amount, 1000 (every contains Gotu Kola P.E 1000mg) are made.
Embodiment 9: Gotu Kola P.E granule
1000 grams of particles (every g are made in Gotu Kola P.E 10g, lactose powder 800g, magnesium stearate 194g, 70% appropriate amount of ethanol
Contain Gotu Kola P.E 10mg in grain system).
Embodiment 10: Gotu Kola P.E soft capsule
Gotu Kola P.E 50g, soybean oil 10g, gelatin 5g, glycerol 5g, distilled water 7g, being made 1000, (every contains centella
Extract 50mg).
Embodiment 11: Gotu Kola P.E injection
Gotu Kola P.E 25.0g is dissolved in 1000ml water for injection, and dissolution is sufficiently stirred, and benefit injects water to 2000ml,
Needle activated carbon 2.5g is added, is heated to 60 DEG C and stirs 30 minutes, carbon-point filtering, filtrate is removed through 0.25 μm of filtering with microporous membrane
Bacterium is sub-packed in 1000 cillin bottles, loading amount 2.0ml/ branch, sealing, sterilizing to get.
Embodiment 12: Gotu Kola P.E and angelica extract composition emulsifiable paste
Centella alcohol extracting thing 1g, Radix Angelicae Sinensis water extract 1g, stearic acid 100g, hexadecanol 20g, glycerin monostearate 10g, liquid
Body paraffin wax 10g, methyl hydroxybenzoate 0.8g, butyl hydroxybenzoate 0.2g, glycerol 140g, potassium hydroxide 5g, ethyl alcohol 10g, distilled water add to
1000g。
Embodiment 13: Gotu Kola P.E and wolfberry fruit extract composition gels
Centella alcohol extracting thing 1g, fructus lycii water extract 1g, PEG400 450g, hexylene glycol 80g, Tween 80 20g, carbomer
30g, ethanol amine 6ml, benzyl alcohol 10g, distilled water add to 1000g.
Embodiment 14: Gotu Kola P.E and glossy privet extractive composition gel
Centella alcohol extracting thing 1g, glossy privet water extract 1g, PEG400 450g, hexylene glycol 80g, Tween 80 20g, carbomer
30g, ethanol amine 6ml, benzyl alcohol 10g, distilled water add to 1000g.
Embodiment 15: Gotu Kola P.E and Semen Cuscutae extract composition gels
Centella alcohol extracting thing 1g, Semen Cuscutae alcohol extracting thing 1g, PEG400 450g, hexylene glycol 80g, Tween 80 20g, carbomer
30g, ethanol amine 6ml, benzyl alcohol 10g, distilled water add to 1000g.
Claims (7)
1. Gotu Kola P.E improves the purposes in gonad granulocyte activity tcm product in preparation.
2. purposes according to claim 1, it is characterised in that Gotu Kola P.E promotes gonad granulocyte to increase in preparation
Grow the purposes in active tcm product.
3. purposes according to claim 1, it is characterised in that Gotu Kola P.E improves gonad granulocyte in preparation
Purposes in the tcm product of estrogen and progestogen secretion level.
4. purposes according to claim 1, it is characterised in that Gotu Kola P.E is matched as active constituent and common auxiliary material
Any one dosage form of tcm product is made；Or as active constituent and other adjust ovarian functions Chinese medical extract and
Auxiliaries are commonly used into any one dosage form allowed in traditional Chinese medicine preparation product.
5. purposes according to claim 4, the dosage form can be tablet, gel, cream, pill, liquid preparation,
Granule, electuary, soft capsule, soft capsule, pill, ointment or injection etc..
6. purposes according to claim 4, auxiliary material used can often use auxiliary material using the dosage form, compound used its
His Chinese medical extract is the extract (alcohol extracting thing or water extract) for adjusting ovarian function Chinese medicine, such as wolfberry fruit extract, Radix Angelicae Sinensis
Extract, glossy privet fruit extract, Semen Cuscutae extract etc..
7. Gotu Kola P.E according to claim 1, it is characterised in that: preparation method is to extract centella by ethyl alcohol
Solid powder after the alcohol extract that medicinal material obtains is dry, extracting method can be decocting method, reflux extraction etc.；Preferred concentration is
Solid powder after the extract that 70-90% ethyl alcohol extracts is dry, extracting method can be decocting method, reflux extraction etc..
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1429553A (en) * | 2001-12-30 | 2003-07-16 | 杭州赛利药物研究有限公司 | Use of centella total glycoside in manufacture of medicine |
-
2019
- 2019-07-19 CN CN201910656959.3A patent/CN110237108A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1429553A (en) * | 2001-12-30 | 2003-07-16 | 杭州赛利药物研究有限公司 | Use of centella total glycoside in manufacture of medicine |
Non-Patent Citations (4)
| Title |
|---|
| （MUCHTAROMAH B , AMITA H , NASIROH I S .: "Combination effect of Centella asiatica (L.) urban and Pluchea indica (L.) urban on uterus weight and uterus and oviduct histological profiles of Rattus norwegicus", 《THE 9TH INTERNATIONAL CONFERENCE ON GLOBAL RESOURCE CONSERVATION (ICGRC) AND AJI FROM RITSUMEIKAN UNIVERSITY》 * |
| 明志君等: "积雪草总苷抗实验性大鼠乳腺增生", 《中国新药与临床杂志》 * |
| 陈乐真: "《妇产科诊断病理学》", 28 February 2002 * |
| 高慧: "《全国名老中医高慧经带胎产杂病论》", 31 March 2018 * |
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