CN110236784A - Aqueous humor acquisition device - Google Patents

Aqueous humor acquisition device Download PDF

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Publication number
CN110236784A
CN110236784A CN201910591476.XA CN201910591476A CN110236784A CN 110236784 A CN110236784 A CN 110236784A CN 201910591476 A CN201910591476 A CN 201910591476A CN 110236784 A CN110236784 A CN 110236784A
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CN
China
Prior art keywords
pipe close
puncture needle
aqueous humor
sucking tube
liquid sucking
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CN201910591476.XA
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Chinese (zh)
Other versions
CN110236784B (en
Inventor
璧垫胶
赵潺
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beijing Huashi Novi Medical Technology Co Ltd
Original Assignee
Beijing Huashi Novi Medical Technology Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beijing Huashi Novi Medical Technology Co Ltd filed Critical Beijing Huashi Novi Medical Technology Co Ltd
Priority to CN201910591476.XA priority Critical patent/CN110236784B/en
Publication of CN110236784A publication Critical patent/CN110236784A/en
Priority to PCT/CN2019/110062 priority patent/WO2021000440A1/en
Priority to PCT/CN2020/096860 priority patent/WO2021000743A1/en
Priority to EP20834808.6A priority patent/EP3995215A4/en
Priority to JP2021577950A priority patent/JP7337967B2/en
Priority to US17/624,393 priority patent/US20220354468A1/en
Application granted granted Critical
Publication of CN110236784B publication Critical patent/CN110236784B/en
Priority to IL289549A priority patent/IL289549A/en
Priority to JP2023134836A priority patent/JP2023164441A/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/007Methods or devices for eye surgery
    • A61F9/00736Instruments for removal of intra-ocular material or intra-ocular injection, e.g. cataract instruments
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/007Methods or devices for eye surgery
    • A61F9/00781Apparatus for modifying intraocular pressure, e.g. for glaucoma treatment

Abstract

The invention discloses a kind of aqueous humor acquisition devices, comprising: outer barrel, including puncture needle installation end and liquid sucking tube installation end;Puncture needle is fixedly installed in puncture needle installation end and including puncture needle inner end and puncture needle outer end;Liquid sucking tube component, the pipe close including liquid sucking tube and for sealing liquid sucking tube nozzle;Wherein, the periphery wall of liquid sucking tube component is equipped with the annular stop part that annular groove and hoop annular groove are arranged, the radial outer end of annular stop part abuts outer barrel internal perisporium, smooth contact is formed between the radially outer edge portion and outer barrel internal perisporium of pipe close and is equipped with the pipe close exhaust passage being arranged along the extending direction of outer barrel barrel chamber, barrel chamber regional connectivity pipe close exhaust passage of the outer barrel barrel chamber between pipe close and puncture needle installation end.By using aqueous humor acquisition device of the invention, safety and reliability during puncture of anterior chamber can be improved, and can be improved the subsequent accuracy to aqueous humor detection.

Description

Aqueous humor acquisition device
Technical field
The present invention relates to medical apparatus technical fields, and in particular, to a kind of aqueous humor acquisition device.
Background technique
Anterior chamber of eyeball's centesis be it is a kind of by instrument pierce through cornea so that aqueous humor outflow medical technology, in ophthalmology There is important application value in clinical research work, being mainly used in, which reduces intraocular pressure, aqueous humor acquisition and other therapeutic anterior chamber, puts Liquid.
For now, the implementation of paracentesis of anterior chamber has no unified special equipment and consumptive material, in actual clinical work Mostly using 1ml syringe needle as paracentesis needle.But during being punctured using the 1ml syringe needle, aqueous humor Drainage speed it is more difficult to control, when tapping is too fast, the rapid decrease of intraocular pressure can be caused, when more serious even can cause other simultaneously Send out disease.Further, since the aqueous humor in syringe cavity is further transferred to microcentrifugal tube after aqueous humor acquisition, Therefore in the process, will cause the waste of aqueous humor, and exist contacted in transfer process with external environment due to aqueous humor and The risk being contaminated, so as to cause testing result there are deviation, reliability is poor.
It can be seen that needing to develop one kind at this stage is able to solve existing safety during puncture of anterior chamber and can By novel acquisition device of property the problems such as poor.
Summary of the invention
In view of the above drawbacks of the prior art or insufficient, the present invention provides a kind of aqueous humor acquisition devices, before can be improved Safety and reliability when room punctures, and improve the subsequent detection accuracy for aqueous humor.
To achieve the above object, the present invention provides a kind of aqueous humor acquisition device, the aqueous humor acquisition device includes:
Outer barrel, including puncture needle installation end and liquid sucking tube installation end;
Puncture needle, be fixedly installed in the puncture needle installation end and be equipped be located at outer barrel barrel chamber in puncture needle inner end and Puncture needle outer end outside the outer barrel barrel chamber;
Liquid sucking tube component, including be inserted into outer barrel barrel chamber and can be moved along axial plug from the liquid sucking tube installation end Dynamic liquid sucking tube and it is arranged in the outer barrel barrel chamber with the pipe close for sealing liquid sucking tube nozzle;
Wherein, the periphery wall of the liquid sucking tube component is equipped with the annular limit of the setting of annular groove described in annular groove and hoop Position part, the radial outer end of the annular stop part abut outer barrel internal perisporium, the radially outer edge portion of the pipe close and the outer cylinder Smooth contact is formed between internal peripheral wall and is equipped with the pipe close exhaust passage being arranged along the extending direction of the outer barrel barrel chamber, institute State pipe close exhaust passage described in barrel chamber regional connectivity of the outer barrel barrel chamber between the pipe close and the puncture needle installation end.
Optionally, the pipe close be equipped with along the axially extending of the outer barrel barrel chamber and along the circumferential direction of the pipe close successively between Every multiple pipe close exhaust passages of arrangement.
Optionally, the pipe close exhaust groove as the pipe close exhaust passage is formed on the periphery wall of the pipe close, it should Pipe close exhaust groove is equipped with the slot opening towards radial outside.
Optionally, the channel peripheral wall of the pipe close exhaust passage is closing peripheral wall.
Optionally, cross section semicircular in shape shape, square configuration or the arcuate shape of the pipe close exhaust passage.
Optionally, the pipe close includes pipe close central part for sealing the liquid sucking tube nozzle and is located in the pipe close The radial outside of center portion and the pipe close outer portion for being equipped with the pipe close exhaust passage, the pipe close outer portion are formed at least partially as Loose ventilation device.
Optionally, the end of the pipe close, which is equipped with, punctures guide hole for guide that the puncture needle inner end penetrates, described The outer contour shape of puncture needle inner end is mutually matched with the shape for puncturing guide hole.
Optionally, peripheral wall exhaust clearance is equipped between the liquid sucking tube and outer barrel internal perisporium, the outer barrel barrel chamber exists Barrel chamber region, the pipe close exhaust passage and the peripheral wall exhaust clearance between the pipe close and the puncture needle installation end according to Secondary connection.
Optionally, the periphery wall of the puncture needle inner end is equipped with the peripheral wall water outlet being connected to the needle cavity of the puncture needle Hole.
Optionally, the puncture needle inner end is additionally provided with the needle cavity along the axial apopore being axially connected to, the peripheral wall The axial spacing at the hole center of apopore and the hole center of the axial apopore is no more than 3mm.
In the present invention, by the way that pipe close exhaust passage is arranged in the radially outer edge portion of pipe close, atmospheric environment and outer can be made Barrel chamber regional connectivity of the cylinder barrel chamber between pipe close and puncture needle installation end avoids forming aeroembolism and shadow in outer barrel barrel chamber The smooth plug for ringing liquid sucking tube component, to improve use reliability.In addition, liquid sucking tube component is due to setting in drainage process There is pipe close and liquid sucking tube lumen is made to be in negative pressure state, when puncture needle inner end punctures pipe close with by aqueous humor drainage to liquid sucking tube pipe When chamber, as the amount of liquid in lumen gradually increases, the difference of intraluminal pressure and preceding intra-atrial pressure power is gradually reduced, so that room The drainage speed of water gradually decreases, to avoid the occurrence of the dangerous situation of intraocular pressure rapid drawdown, greatly improves safety.Furthermore it is adopting After collection, liquid sucking tube component can integrally be extracted from outer barrel barrel chamber, and directly the aqueous humor in liquid sucking tube is detected, It need not make further transfer, therefore the aqueous humor that can avoid in lumen is contacted with external environment, guarantees the pure of aqueous humor collected Degree, to improve the accuracy of subsequent detection.
Other features and advantages of the present invention will the following detailed description will be given in the detailed implementation section.
Detailed description of the invention
The drawings are intended to provide a further understanding of the invention, and constitutes part of specification, with following tool Body embodiment is used to explain the present invention together, but is not construed as limiting the invention.In the accompanying drawings:
Fig. 1 is the perspective view of the aqueous humor acquisition device in a specific embodiment of the invention;
Fig. 2 is the main view of the aqueous humor acquisition device in Fig. 1;
Fig. 3 is main sectional view of the aqueous humor acquisition device when puncture needle does not puncture pipe close in Fig. 2;
Fig. 4 is that the aqueous humor acquisition device in Fig. 3 is equipped with the main sectional view prevented when puncturing separator;
Fig. 5 is the cross sectional view of the aqueous humor acquisition device in Fig. 1;
Fig. 6 is equipped with structural schematic diagram when peripheral wall apopore for the puncture needle of the aqueous humor acquisition device in Fig. 3;
Fig. 7 is that the pipe close of the aqueous humor acquisition device in Fig. 3 is equipped with that peripheral wall is open and the pipe close exhaust passage of semicircular in shape When structural schematic diagram;
Fig. 8 be Fig. 3 in aqueous humor acquisition device pipe close be equipped with peripheral wall it is open and be in half rectangle pipe close exhaust passage When structural schematic diagram;
When Fig. 9 is that the pipe close of the aqueous humor acquisition device in Fig. 3 is equipped with peripheral wall closed and rounded pipe close exhaust passage Structural schematic diagram;
When Figure 10 is that the pipe close of the aqueous humor acquisition device in Fig. 3 is equipped with peripheral wall closed and arc-shaped pipe close exhaust passage Structural schematic diagram;
The structural representation when liquid sucking tube and support pipe support that Figure 11 is the aqueous humor acquisition device in Fig. 3 are connected by a snap Figure;
Figure 12 is that the liquid sucking tube of the aqueous humor acquisition device in a specific embodiment of the invention is integrally formed out convex dot shape Structural schematic diagram when retention bead;
Figure 13 is integrally formed out undulatory for the liquid sucking tube of the aqueous humor acquisition device in a specific embodiment of the invention Structural schematic diagram when retention bead;
Figure 14 is that the liquid sucking tube of the aqueous humor acquisition device in a specific embodiment of the invention is cased with pipe sleeve part and limit outside Structural schematic diagram when protrusion is in convex dot shape;
Figure 15 is that the liquid sucking tube of the aqueous humor acquisition device in a specific embodiment of the invention is cased with pipe sleeve part and limit outside Structural schematic diagram when protrusion is corrugated;
Figure 16 is that the liquid sucking tube of the aqueous humor acquisition device in a specific embodiment of the invention is cased with pipe sleeve part and limit outside Structural schematic diagram when protrusion is in helical teeth shape;
Figure 17 is that the support pipe support of the aqueous humor acquisition device in a specific embodiment of the invention is integrally formed out convex dot shape Retention bead when structural schematic diagram;
Figure 18 is that the support pipe support of the aqueous humor acquisition device in a specific embodiment of the invention is integrally formed out corrugated Retention bead when structural schematic diagram;
Figure 19 is that the support pipe support of the aqueous humor acquisition device in a specific embodiment of the invention is integrally formed out helical teeth shape Retention bead when structural schematic diagram;
Figure 20 is that the support pipe support housing of the aqueous humor acquisition device in a specific embodiment of the invention has pipe sleeve part and limit Structural schematic diagram when position protrusion is in convex dot shape;
Figure 21 is that the support pipe support housing of the aqueous humor acquisition device in a specific embodiment of the invention has pipe sleeve part and limit Structural schematic diagram when position protrusion is corrugated;
Figure 22 is that the support pipe support housing of the aqueous humor acquisition device in a specific embodiment of the invention has pipe sleeve part and limit Structural schematic diagram when position protrusion is in helical teeth shape.
Description of symbols:
100 aqueous humor acquisition devices
1 outer barrel, 2 puncture needle
3 liquid sucking tube component, 4 needle stand
5 prevent puncturing 6 retention bead of separator
The soft set of 7 needle cap 8
11 separator inserting groove, 21 peripheral wall apopore
22 31 liquid sucking tubes of axial apopore
32 support 33 pipe closes of pipe support
34 pipe sleeve part, 35 annular groove
36 groove venthole, 37 annular stop part
311 liquid sucking tube card slot, 321 pipe support buckle
322 pipe supports buckle 331 pipe close exhaust passage of button
332 puncture guide hole
Specific embodiment
Specific embodiments of the present invention are described in detail below in conjunction with attached drawing.It should be understood that described herein Specific embodiment be merely to illustrate and explain the present invention, be not intended to restrict the invention.
Below with reference to the accompanying drawings aqueous humor acquisition device according to the present invention is described.
As shown in Fig. 1 to Figure 16, the exemplary embodiment of the present invention provides a kind of aqueous humor acquisition device 100, the aqueous humors Acquisition device 100 includes outer barrel 1, puncture needle 2 and liquid sucking tube component 3.Outer barrel 1 is equipped with the puncture needle peace positioned at axial ends Fill end and liquid sucking tube installation end.Puncture needle 2 is fixedly installed in puncture needle installation end and is equipped with the puncture being located in outer barrel barrel chamber Needle inner end and the puncture needle outer end outside outer barrel barrel chamber.Liquid sucking tube component 3 includes being inserted into outer cylinder from liquid sucking tube installation end It can be used in body barrel chamber and in outer barrel barrel chamber seal liquid sucking tube pipe along the liquid sucking tube 31 moved and setting is axially plugged The pipe close 33 of mouth.Wherein, the confficient of static friction between pipe close 33 and outer barrel internal perisporium is μ 1, pipe close 33 and liquid sucking tube nozzle it Between confficient of static friction be μ 2, and meet: 1 < μ 2 of μ.Alternatively, pipe close 33 can be interval in the setting of outer barrel internal perisporium, to guarantee Pipe close 33 is not in contact with each other with outer barrel internal perisporium.
When carrying out puncture of anterior chamber using the aqueous humor acquisition device 100 in exemplary embodiment of the present invention, liquid can will be adopted Tube assembly 3 is elapsed towards puncture needle inner end, so that puncture needle inner end is inserted into liquid sucking tube lumen after puncturing soft set 8 and pipe close 33 In, the aqueous humor in anterior chamber is drained to liquid sucking tube lumen by puncture needle outer end and puncture needle inner end.In this collection process, Since liquid sucking tube nozzle is sealed by pipe close 33, liquid sucking tube lumen always is in a state of negative pressure, but with the amount of liquid in lumen by Cumulative more, the difference of intraluminal pressure and preceding intra-atrial pressure power is gradually reduced, therefore the drainage speed of aqueous humor can be made to gradually decrease, from And the dangerous situation of intraocular pressure rapid drawdown is avoided the occurrence of, greatly improve the safety of puncture drainage.
Further, after aqueous humor acquisition, liquid sucking tube component 3 can integrally be extracted from outer barrel barrel chamber, then Liquid sucking tube 31 is directly placed in progress specific project detection in particular detection instrument, compared with prior art, without to acquisition Aqueous humor afterwards makees further transfer, therefore the aqueous humor that can avoid in liquid sucking tube lumen is contacted with external environment, guarantees collected The degree of purity of aqueous humor to improve the accuracy and reliability of subsequent detection, and can be avoided due to caused by transfer aqueous humor Waste.
Further, since define confficient of static friction μ 1 between pipe close 33 and outer barrel internal perisporium be less than pipe close 33 with it is described Confficient of static friction between liquid sucking tube nozzle is μ 2, or pipe close 33 is interval in the setting of outer barrel internal perisporium, it is ensured that is being incited somebody to action When liquid sucking tube component 3 is integrally extracted from outer barrel barrel chamber, pipe close 33 securely blocks liquid sucking tube nozzle always, thus more reliable Ground guarantees the degree of purity of aqueous humor collected.
In some embodiments, when pipe close 33 and outer barrel internal perisporium contact with each other, preferably to avoid pipe close 33 de- It falls, will be preferably arranged between pipe close 33 and outer barrel internal perisporium through smooth face contact.For example, can be outside by the diameter of pipe close 33 End face or outer barrel inner peripheral wall are set as shiny surface, or simultaneously by the radial outer end face of pipe close 33 and outer barrel inner peripheral wall It is set as shiny surface.
In some embodiments, aqueous humor acquisition device 100 includes radial along outer barrel barrel chamber for limiting liquid sucking tube component 3 The anti-rock structure of displacement.Under such configuration, it is ensured that liquid sucking tube component 3 plug moving process in be only axially moveable without It will appear radial shaking, not only can guarantee that puncture needle inner end punctures pipe close 33 accurately to be inserted into liquid sucking tube in puncture process In lumen, moreover it is possible to guarantee steadily to extract liquid sucking tube component 3 after aqueous humor acquires, to avoid the intraluminal aqueous humor of liquid sucking tube Leakage, to further increase the accuracy and reliability of subsequent detection.
As shown in Figure 3 and Figure 4, anti-rock structure may include the annular groove being formed on the periphery wall of liquid sucking tube component 3 35 and the annular stop part 37 that is arranged of hoop annular groove 35, the radial outer end of the annular stop part 37 abut outer barrel inner circumferential Wall.It should be noted that annular stop part 37 is in addition to that can prevent the radial of liquid sucking tube component 3 from shaking so that in puncture process Puncture needle inner end is more accurate when puncturing pipe close 33 and prevents other than deviation, moreover it is possible to suitably increase the plug of liquid sucking tube component 3 Resistance allows the operator to experience certain passage feel, thus avoid by liquid sucking tube component 3 towards puncture needle inner end It causes to puncture not accurate situation due to passage excessive velocities when passage, and then avoids puncture needle inner end that from cannot being inserted into and adopt liquid In pipe lumen, that is, effectively improve the stability and reliability of puncture drainage process.In addition, can also prevent in aqueous humor acquisition dress of taking Liquid sucking tube component 3 isolates and falls off with outer barrel when setting 100, to improve the reliability of product.Preferably, settable multiple groups annular Groove 35 and corresponding annular stop part 37, to obtain better effect.
To reduce production difficulty and reducing production cost, annular stop part 37 can be preferably arranged to be easily obtained, is cheap The elastic tape or other elastic rings of object beauty, and formed between annular stop part 37 and outer barrel internal perisporium made of the elastic material Elastic Contact can avoid excessive friction and wear outer barrel internal perisporium.
Further, can the recess sidewall of annular groove 35 be formed with along outer barrel barrel chamber axially through groove it is logical Stomata 36 enables barrel chamber region of the outer barrel barrel chamber between pipe close 33 and puncture needle installation end to pass through the groove venthole 36 are connected to atmospheric environment, and the smooth plug of liquid sucking tube component 3 is influenced to avoid the formation aeroembolism in outer barrel barrel chamber, thus Improve the use reliability of aqueous humor acquisition device 100.
As shown in Figure 12 to Figure 16, anti-rock structure may also include from the periphery wall of liquid sucking tube component 3 or out of outer barrel The retention bead 6 of peripheral wall protrusion, the radial both ends of the retention bead 6 are separately connected the periphery wall and outer barrel of liquid sucking tube component 3 Internal perisporium, to prevent liquid sucking tube component 3 from generating radial shaking.
When the periphery wall of liquid sucking tube component 3 is arranged in retention bead 6, retention bead 6 can be integrally formed in liquid sucking tube On 31 periphery wall.Alternatively, the pipe sleeve part 34 being coated on the periphery wall of liquid sucking tube 31 can be set in liquid sucking tube component 3, and Retention bead 6 is arranged on the periphery wall of pipe sleeve part 34, since pipe sleeve part 34 is knockdown pieces, can reuse, And the difficulty that retention bead 6 is molded on pipe sleeve part 34 is relatively smaller, is more advantageous to reduction production cost.
Further, elastic tube external member can be set by pipe sleeve part 34, to prevent liquid sucking tube 31 from making by radial limit Used time is ruptured due to rigid contact, to reduce the risk of aqueous humor leakage.
In some embodiments, anti-rock structure may include the multiple retention beads 6 being circumferentially successively intervally arranged, and can protect It demonstrate,proves liquid sucking tube 31 and outer barrel barrel chamber is coaxially disposed, to guarantee that liquid sucking tube 31 is moved along axial smooth plug.Further, since phase Exhaust clearance is formed between the multiple retention beads 6 being mutually spaced, outer barrel barrel chamber is between puncture needle installation end and pipe close 33 Barrel chamber region can by the exhaust clearance be connected to atmospheric environment, thus avoid in outer barrel barrel chamber formed aeroembolism and influence to adopt The smooth plug of liquid pipe component 3.For example, referring to Figure 12 and Figure 14, the multiple retention beads 6 being circumferentially successively intervally arranged can be set It is set in convex dot shape.
Alternatively, in some embodiments, retention bead 6 can also extend continuously in a circumferential molding.When retention bead 6 is formed in When outer barrel internal perisporium, it is preferably formed with exhaust clearance between retention bead 6 and the periphery wall of liquid sucking tube component 3, to avoid Form aeroembolism.When retention bead 6 is formed in the periphery wall of liquid sucking tube component 3, between retention bead 6 and outer barrel internal perisporium It is preferably formed with exhaust clearance.For example, referring to Figure 13, Figure 15 and Figure 16, extending continuously in a circumferential molding retention bead 6 can It is set as corrugated or helical teeth shape.
For the plug stability for further increasing liquid sucking tube component 3, no matter retention bead 6 is pipe along liquid sucking tube component 3 Length direction is successively spaced setting, or is extended continuously molding along pipe range direction, it is preferably to which ground is by retention bead 6 along pipe range direction Total span be set as the half not less than liquid sucking tube pipe range.In other words, when retention bead 6 is in the arrangement number on pipe range direction When measuring enough, it can avoid forming balance pivot on the periphery wall of liquid sucking tube component 3, to be more reliably prevented from liquid sucking tube group Part 3 radially shakes.
In some embodiments, liquid sucking tube component 3 further includes the support pipe support 32 for liquid sucking tube 31 to be fixedly mounted.Herein , can be by anti-rock structure setting between the periphery wall and outer barrel internal perisporium of support pipe support 32 under structure, such as can refer to figure 17 to shown in Figure 22.The support pipe support 32 can preferably improve the stability of liquid sucking tube component 3 and can reduce liquid sucking tube The risk that component 3 is ruptured due to being collided or pressing passage.
Due to after aqueous humor acquires, needing individually to take out liquid sucking tube, thus liquid sucking tube 31 and support pipe support 32 it Between connection type to meet the requirement of stability and fast assembling-disassembling simultaneously.Preferably, between liquid sucking tube 31 and support pipe support 32 Fixation can be fixed or snapped connection by being spirally connected.
For example, referring to Figure 11, it is connected by a snap between liquid sucking tube 31 and support pipe support 32, when needing to insert liquid sucking tube 31 When in support pipe support 32, liquid sucking tube 31 is elapsed to the right, until pipe support buckle 321 is caught in liquid sucking tube card slot 311 So that liquid sucking tube 31 and support pipe support 32 mutually buckle locking.When needing to take out liquid sucking tube 31, pressable pipe support buckles button 322, so that 321 lifting of pipe support buckle to be detached from liquid sucking tube card slot 311, can quickly take liquid sucking tube 31 from support pipe support 32 Out.
In some embodiments, aqueous humor acquisition device 100 further includes the needle stand 4 for puncture needle 2 to be fixedly mounted.Wherein, Puncture needle outer end is stretched out from needle stand outer end and puncture needle inner end is stretched out from needle stand inner end, and needle stand inner end and puncture needle installation end Between formed fast insert-pull connection, installation difficulty is advantageously reduced, to improve assembly efficiency.For example, needle stand inner end and puncture Screw thread grafting or buckle grafting can be formed between needle installation end.
In some embodiments, aqueous humor acquisition device 100 further includes preventing puncturing separator 5, this prevents that puncturing separator 5 is used for Along the axial that puncture needle inner end and pipe close 33 is mutually isolated of outer barrel barrel chamber, to prevent in unused aqueous humor acquisition device 100 Puncture needle inner end punctures pipe close 33 in the case where carrying out puncture of anterior chamber, i.e., the failure before being not used of effective avoiding device.For example, In transit or when medical staff's maloperation, which can prevent aqueous humor acquisition device 100 from failing.When So, in order to not influence the normal puncture drainage of aqueous humor acquisition device 100, anti-will puncture separator 5 and be set as knockdown pieces, into Before row punctures, it can will prevent that puncturing separator 5 removes.
For example, referring to Fig. 4, separator inserting groove 11 can be set in the peripheral wall of outer barrel 1, and make the separator inserting groove 11 and barrel chamber region of the outer barrel barrel chamber between puncture needle inner end and pipe close 33 be interconnected, it is anti-to puncture separator 5 and pass through The separator inserting groove 11 is inserted into the barrel chamber region, is placed between puncture needle inner end and pipe close 33, thus by puncture needle Inner end and pipe close 33 are mutually isolated.When needing dismounting to prevent puncturing separator 5, it can quickly be pulled out from separator inserting groove 11 Out, it operates quite convenient.
In some embodiments, as shown in Figure 7 to 10, preferably to avoid forming aeroembolism and shadow in outer barrel barrel chamber The smooth plug of liquid sucking tube component 3 is rung, the extending direction setting along outer barrel barrel chamber can be formed in the radially outer edge portion of pipe close 33 Pipe close exhaust passage 331, barrel chamber region of the outer barrel barrel chamber between pipe close 33 and puncture needle installation end can pass through the pipe close Peripheral wall exhaust clearance between exhaust passage 331 and above-mentioned liquid sucking tube 31 and outer barrel internal perisporium is connected to atmospheric environment.It changes Yan Zhi, barrel chamber region, pipe close exhaust passage 331 and peripheral wall exhaust of the outer barrel barrel chamber between pipe close 33 and puncture needle installation end Gap is sequentially communicated and atmospheric environment is sequentially communicated.
It is more uniform rationally for the structure that improves ventilatory effect and make pipe close 33, it is arranged and prolongs along the axial direction of outer barrel barrel chamber The multiple pipe close exhaust passages 331 stretched, and be successively intervally arranged along the circumferential direction of pipe close 33.
The concrete shape of pipe close exhaust passage 331 can be depending on actual needs, can be in pipe close for example, referring to Fig. 7 and Fig. 8 The pipe close exhaust groove as pipe close exhaust passage 331 is formed on 33 periphery wall, which is equipped with towards diameter Slot opening outward.In other words, pipe close exhaust passage 331 can be set to the open exhaust passage of peripheral wall.Alternatively, ginseng According to Fig. 9 and Figure 10, the channel peripheral wall of pipe close exhaust passage 331 can be set to closing peripheral wall, it can be by pipe close exhaust passage 331 It is set as the enclosed exhaust passage of peripheral wall.In addition, the cross section of pipe close exhaust passage 331 may be configured as semicircular in shape, rectangular Or the different shapes such as arc.
In some embodiments, pipe close 33 includes pipe close central part for sealing liquid sucking tube nozzle and is located at pipe close center The radial outside in portion and the pipe close outer portion for being equipped with pipe close exhaust passage 331 can be by pipe close outer rings to guarantee to realize inside and outside ventilation Portion is at least partly set as loose ventilation device, but still needs to guarantee that pipe close central part has leakproofness.
It, can be in pipe close 33 to guarantee that puncture needle inner end will not generate shaking when puncturing pipe close 33 and influence to puncture accuracy End setting puncture guide hole 332 for what biopsy needle guide inner end penetrated, and make the outer contour shape of puncture needle inner end It is mutually matched with the shape for puncturing guide hole 332.For example, referring to Fig. 3, by puncture needle inner end and guide hole 332 can be punctured it is arranged For the long conical by its shape being mutually matched.
It should be noted that during puncture needle inner end punctures pipe close 33, it is possible that the axis of puncture needle inner end The case where being blocked to apopore 22 by pipe close material, so as to cause drainage is blocked and makes device cisco unity malfunction.Therefore, To avoid the occurrence of cutout situation, the peripheral wall water outlet being connected to the needle cavity of puncture needle 2 can be set on the periphery wall of puncture needle inner end Hole 21, under such configuration, even if axial apopore 22 is blocked by pipe close material, aqueous humor can also be flowed out to by peripheral wall apopore 21 In liquid sucking tube lumen, to guarantee the functional reliability of device.
In addition, peripheral wall apopore 21 and the axial spacing of axial apopore 22 should not be too large, otherwise when axial apopore 22 After being inserted into liquid sucking tube lumen, peripheral wall apopore 21 is still located in pipe close 33 and is blocked, so as to cause peripheral wall apopore 21 Lose effectiveness.For this purpose, the hole center of peripheral wall apopore 21 and the axial spacing at the hole center of axial apopore 22 preferably can be set It is set to no more than 3mm, to guarantee that peripheral wall apopore 21, which may be alternatively located at, adopts liquid after axial apopore 22 is inserted into liquid sucking tube lumen Without being blocked in pipe lumen.
In the description of the present invention, it is to be understood that, term " center ", " longitudinal direction ", " transverse direction ", " length ", " width ", " thickness ", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom" "inner", "outside", " up time The orientation or positional relationship of the instructions such as needle ", " counterclockwise ", " axial direction ", " radial direction ", " circumferential direction " be orientation based on the figure or Positional relationship is merely for convenience of description of the present invention and simplification of the description, rather than the device or element of indication or suggestion meaning must There must be specific orientation, be constructed and operated in a specific orientation, therefore be not considered as limiting the invention.
In addition, term " first ", " second " are used for descriptive purposes only and cannot be understood as indicating or suggesting relative importance Or implicitly indicate the quantity of indicated technical characteristic.Define " first " as a result, the feature of " second " can be expressed or Implicitly include at least one this feature.In the description of the present invention, the meaning of " plurality " is at least two, such as two, three It is a etc., unless otherwise specifically defined.
In the present invention unless specifically defined or limited otherwise, term " installation ", " connected ", " connection ", " fixation " etc. Term shall be understood in a broad sense, for example, it may be being fixedly connected, may be a detachable connection, or integral;It can be mechanical connect It connects, is also possible to be electrically connected or can communicate each other;It can be directly connected, can also indirectly connected through an intermediary, it can be with It is the interaction relationship of the connection or two elements inside two elements, unless otherwise restricted clearly.For this field For those of ordinary skill, the specific meanings of the above terms in the present invention can be understood according to specific conditions.
In the present invention unless specifically defined or limited otherwise, fisrt feature in the second feature " on " or " down " can be with It is that the first and second features directly contact or the first and second features pass through intermediary mediate contact.Moreover, fisrt feature exists Second feature " on ", " top " and " above " but fisrt feature be directly above or diagonally above the second feature, or be merely representative of First feature horizontal height is higher than second feature.Fisrt feature can be under the second feature " below ", " below " and " below " One feature is directly under or diagonally below the second feature, or is merely representative of first feature horizontal height less than second feature.
In the description of this specification, reference term " one embodiment ", " some embodiments ", " example ", " specifically show The description of example " or " some examples " etc. means specific features, structure, material or spy described in conjunction with this embodiment or example Point is included at least one embodiment or example of the invention.In the present specification, schematic expression of the above terms are not It must be directed to identical embodiment or example.Moreover, particular features, structures, materials, or characteristics described can be in office It can be combined in any suitable manner in one or more embodiment or examples.In addition, without conflicting with each other, the skill of this field Art personnel can tie the feature of different embodiments or examples described in this specification and different embodiments or examples It closes and combines.
Although the embodiments of the present invention has been shown and described above, it is to be understood that above-described embodiment is example Property, it is not considered as limiting the invention, those skilled in the art within the scope of the invention can be to above-mentioned Embodiment is changed, modifies, replacement and variant.

Claims (10)

1. a kind of aqueous humor acquisition device, which is characterized in that the aqueous humor acquisition device (100) includes:
Outer barrel (1), including puncture needle installation end and liquid sucking tube installation end;
Puncture needle (2), be fixedly installed in the puncture needle installation end and be equipped be located at outer barrel barrel chamber in puncture needle inner end and Puncture needle outer end outside the outer barrel barrel chamber;
Liquid sucking tube component (3), including be inserted into outer barrel barrel chamber and can be moved along axial plug from the liquid sucking tube installation end Dynamic liquid sucking tube (31) and it is arranged in the outer barrel barrel chamber with the pipe close (33) for sealing liquid sucking tube nozzle;
Wherein, the periphery wall of the liquid sucking tube component (3) is equipped with the setting of annular groove (35) described in annular groove (35) and hoop Annular stop part (37), the radial outer end of the annular stop part (37) abuts outer barrel internal perisporium, the pipe close (33) Smooth contact is formed between radially outer edge portion and the outer barrel internal perisporium and is equipped with the extending direction along the outer barrel barrel chamber The pipe close exhaust passage (331) of setting, the outer barrel barrel chamber is between the pipe close (33) and the puncture needle installation end Pipe close exhaust passage (331) described in barrel chamber regional connectivity.
2. aqueous humor acquisition device according to claim 1, which is characterized in that the pipe close (33) is equipped with along the outer barrel Multiple pipe close exhaust passages (331) that axially extending and along the pipe close (33) the circumferential direction of barrel chamber is successively intervally arranged.
3. aqueous humor acquisition device according to claim 1, which is characterized in that be formed on the periphery wall of the pipe close (33) As the pipe close exhaust groove of the pipe close exhaust passage (331), which is equipped with the groove towards radial outside Opening.
4. aqueous humor acquisition device according to claim 1, which is characterized in that the channel of the pipe close exhaust passage (331) Peripheral wall is closing peripheral wall.
5. aqueous humor acquisition device according to claim 1, which is characterized in that the pipe close exhaust passage (331) it is transversal Face semicircular in shape shape, square configuration or arcuate shape.
6. aqueous humor acquisition device according to claim 1, which is characterized in that the pipe close (33) includes described for sealing The pipe close central part of liquid sucking tube nozzle and positioned at the pipe close central part radial outside and be equipped with the pipe close exhaust passage (331) pipe close outer portion, the pipe close outer portion are formed at least partially as loose ventilation device.
7. aqueous humor acquisition device according to claim 1, which is characterized in that the end of the pipe close (33) is equipped with for drawing That leads that the puncture needle inner end penetrates punctures guide hole (332), and outer contour shape and described puncture of the puncture needle inner end are led The shape of blind hole (332) is mutually matched.
8. aqueous humor acquisition device according to claim 1, which is characterized in that the liquid sucking tube (31) and outer barrel internal perisporium Between be equipped with peripheral wall exhaust clearance, barrel chamber of the outer barrel barrel chamber between the pipe close (33) and the puncture needle installation end Region, the pipe close exhaust passage (331) and the peripheral wall exhaust clearance are sequentially communicated.
9. aqueous humor acquisition device described according to claim 1~any one of 8, which is characterized in that the puncture needle inner end Periphery wall be equipped with the peripheral wall apopore (21) that is connected to the needle cavity of the puncture needle (2).
10. aqueous humor acquisition device according to claim 9, which is characterized in that the puncture needle inner end be additionally provided with it is described Needle cavity is along the axial apopore (22) being axially connected to, the hole center of the peripheral wall apopore (21) and the axial apopore (22) Hole center axial spacing be no more than 3mm.
CN201910591476.XA 2019-07-02 2019-07-02 Aqueous humor collecting device Active CN110236784B (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
CN201910591476.XA CN110236784B (en) 2019-07-02 2019-07-02 Aqueous humor collecting device
PCT/CN2019/110062 WO2021000440A1 (en) 2019-07-02 2019-10-09 Aqueous humor collection device and aqueous humor collection method
JP2021577950A JP7337967B2 (en) 2019-07-02 2020-06-18 Reagent holder, detection device assembly, aqueous humor collection device and aqueous humor collection method
EP20834808.6A EP3995215A4 (en) 2019-07-02 2020-06-18 Reagent holder, testing apparatus assembly, aqueous humor collection device and aqueous humor collection method
PCT/CN2020/096860 WO2021000743A1 (en) 2019-07-02 2020-06-18 Reagent holder, testing apparatus assembly, aqueous humor collection device and aqueous humor collection method
US17/624,393 US20220354468A1 (en) 2019-07-02 2020-06-18 Reagent holder, testing apparatus assembly, aqueous humor collection device and aqueous humor collection method
IL289549A IL289549A (en) 2019-07-02 2022-01-02 Reagent holder, testing apparatus assembly, aqueous humor collection device and aqueous humor collection method
JP2023134836A JP2023164441A (en) 2019-07-02 2023-08-22 Reagent holder, detection device assembly, aqueous humor sampling device, and aqueous humor sampling method

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