CN110236563A - A kind of BOLD contrast and ring-shape pulse blood oxygen instrument - Google Patents
A kind of BOLD contrast and ring-shape pulse blood oxygen instrument Download PDFInfo
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- CN110236563A CN110236563A CN201810192258.4A CN201810192258A CN110236563A CN 110236563 A CN110236563 A CN 110236563A CN 201810192258 A CN201810192258 A CN 201810192258A CN 110236563 A CN110236563 A CN 110236563A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
- A61B5/14551—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
- A61B5/14551—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases
- A61B5/14552—Details of sensors specially adapted therefor
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
- A61B5/6802—Sensor mounted on worn items
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
- A61B5/7225—Details of analog processing, e.g. isolation amplifier, gain or sensitivity adjustment, filtering, baseline or drift compensation
Abstract
A kind of BOLD contrast, including light source, photonic crystal, optical detector and data processing module；Light source includes three LED arrays, and three LED array difference launch wavelengths are the optical signal of 650nm, 805nm and 930nm；Photonic crystal is set in front of optical detector, and the optical signal of light source transmitting is by being incident to optical detector after photonic crystal；Optical detector is for detecting the optical signal for being incident to its surface；Data processing module is connected with optical detector, and data processing module carries out signal processing and obtains oximetry data.Above-mentioned BOLD contrast can reduce requirement of the system to LED stability using LED array as light source, and improve accuracy of measurement.By the way that photonic crystal is arranged before optical detector, it can use the light that the filtering of its frequency selective characteristic is not belonging to the wave band of three LED arrays used, reduce influence of the external environmental light to measurement result, keep testing result more accurate.Further, it would be desirable to provide a kind of small in size, comfortable wearings, measure accurate ring-shape pulse blood oxygen instrument.
Description
Technical field
The present invention relates to blood oxygen the field of test technology more particularly to a kind of BOLD contrasts and ring-shape pulse blood oxygen instrument.
Background technique
Blood oxygen saturation reflect blood in oxygen content number, be detect human health important physiological parameter.
Currently, the noninvasive blood oxygen measuring method based on langbobier law be divided into transmission-type with it is reflective.Its principle
It is all to take dual wavelength or multi-wavelength light to be incident on the absorption difference of light according to oxyhemoglobin and reduced hemoglobin
In tissue, emergent light is detected by optical detector, is calculated by a series of formula, obtains human body blood oxygen saturation.Root
It is believed that the difference of number reception processing mode, and it is divided into processing of circuit method and Dynamic spectrum.Processing of circuit method utilizes photoelectric conversion
The signal changed with arteriopalmus is obtained, obtains blood oxygen saturation by a series of amplifications, filtering, alternating current-direct current separation etc.；It is dynamic
State spectroscopic methodology utilizes the full variation with absorbance when arterial contraction of artery, fortune by the absorbance of blood under extraction multi-wavelength
Calculation obtains blood oxygen saturation.With science and technology and social economy development, pulse blood oxygen instrument have been developed that it is desk-top, refer to folder
Formula, Wristwatch type etc. simultaneously constantly develop to miniaturization, wireless penetration, portability.
Current most popular BOLD contrast is that dual wavelength transmission-type refers to clip-type BOLD contrast, is had the following disadvantages:
1, every kind of only one LED of wavelength requires LED stability high.
2, measurement result is interfered vulnerable to external environmental light.
3, shape is to refer to clip-type, cannot be suitble to all individuals, can cause to squeeze to finger, not only reduce wearing BOLD contrast
Comfort level to prevent it from long periods of wear, the blood volume variation squeezed in bring blood vessel also will affect the accurate of Oximetry
Degree.
Summary of the invention
In consideration of it, it is necessary to provide it is a kind of can long periods of wear, stabilization, small BOLD contrast and ring-shape arteries and veins are interfered by ambient light
It fights BOLD contrast.
A kind of BOLD contrast, including light source, photonic crystal, optical detector and data processing module；
The light source includes the LED array of three transmitting different wave length optical signals；
The photonic crystal is set in front of the optical detector, and the optical signal of the light source transmitting passes through the photonic crystal
After be incident to the optical detector；
The optical detector is converted to electric current letter for detecting the optical signal for being incident to its surface, and by the optical signal
Number；
The data processing module is connected with the optical detector, and the data processing module is for receiving the optical detection
The current signal that device is sent, and handled the current signal to obtain oximetry data.
In one embodiment, three LED array difference launch wavelengths are the light of 650nm, 805nm and 930nm
Signal.
The data processing module includes signal processing module in one of the embodiments, the signal processing module
Computer is handled and is sent to for the current signal to be converted to voltage signal, the computer is according to the voltage
Signal calculates oximetry data.
The signal processing module is converted to the current signal at voltage signal in one of the embodiments,
The operation of reason are as follows:
The signal processing module current signal is converted to amplify after voltage signal filtering, direct current biasing and
The processing of NAND gate reverse phase.
The data processing module further includes bluetooth module in one of the embodiments, the bluetooth module and described
Signal processing module connection, the bluetooth module are used for that treated that voltage signal is sent to calculating by the signal processing module
Machine.
The photonic crystal includes the object with differing dielectric constant of periodic arrangement in one of the embodiments,
Matter, and there is at least one of point defect, line defect or planar defect in the photonic crystal.
The photonic crystal includes the SiO of One Dimension Periodic arrangement in one of the embodiments,2Layer and TiO2Layer,
In, SiO2Layer and TiO2Layer alternate intervals arrange, doped with one layer of KTaO in the photonic crystal3Layer.
The signal processing module includes sequentially connected receiving unit, preposition amplification list in one of the embodiments,
Member, the first high pass filter unit, the first low-pass filter unit, secondary amplifying unit, the second high pass filter unit, the second low pass filtered
Wave unit and direct current biasing unit, and the NAND gate rp unit connected with the pre-amplifier unit.
A kind of ring-shape pulse blood oxygen instrument, including ring support, light source, photonic crystal, optical detector and data processing mould
Block；
The ring support includes the first mounting portion, the second mounting portion, first elastic webbing and second elastic webbing；
First mounting portion and second mounting portion are oppositely arranged；
One end of the first elastic webbing is connected with one end of first mounting portion, the other end of the first elastic webbing
It is connected with one end of second mounting portion；
One end of the second elastic webbing is connected with the other end of first mounting portion, the second elastic webbing it is another
End is connected with the other end of second mounting portion；
The light source is set in first mounting portion, and the front of the light source is equipped with first through hole, the light of the light source
Signal is emitted through the first through hole, and the light source includes the LED array of three transmitting different wave length optical signals；
The photonic crystal and the optical detector are set in second mounting portion, and the photonic crystal is set to described
In front of optical detector, the front of the photonic crystal is equipped with the second through-hole, and the optical signal of the light source transmitting passes through described second
Through-hole is incident to the photonic crystal, and the optical signal of the light source transmitting is by being incident to the optical detection after the photonic crystal
Device；
The optical detector is converted to electric current letter for detecting the optical signal for being incident to its surface, and by the optical signal
Number；
The data processing module is connected with the optical detector, and the data processing module is for receiving the optical detection
The current signal that device is sent, and handled the current signal to obtain oximetry data.
In one of the embodiments, first mounting portion include the first water absorption layer stacked gradually, the first water barrier,
First circuit layer and the first protective layer, the light source are set to the first circuit layer, and the first through hole is inhaled through described first
Water layer and first water barrier；
Second mounting portion includes the second water absorption layer stacked gradually, the second water barrier, the second circuit layer and the second guarantor
Sheath, the photonic crystal and the optical detector are set to the second circuit layer, and second through-hole runs through described second
Water absorption layer and second water barrier；
First water absorption layer and second water absorption layer are oppositely arranged；
The both ends of first elastic webbing one end with one end of first protective layer and second protective layer respectively
It is fixedly connected, the both ends of the second elastic webbing are another with the other end of first protective layer and second protective layer respectively
One end is fixedly connected.
Above-mentioned BOLD contrast can reduce requirement of the system to LED stability using LED array as light source, and improve survey
Measure accuracy.By the way that photonic crystal is arranged before optical detector, it can use the filtering of its frequency selective characteristic and be not belonging to used three
The light of the wave band of a LED array reduces influence of the external environmental light to measurement result, keeps testing result more accurate.
Above-mentioned ring-shape pulse blood oxygen instrument, small in size, comfortable wearing can be worn for a long time, be easy to connect with mobile phone, computer
It connects, realizes the long-term monitoring of blood oxygen, and small by environment shadow sound, measure more acurrate.
Detailed description of the invention
Fig. 1 is the structural schematic diagram of the BOLD contrast of an embodiment；
Fig. 2 is the structural schematic diagram of the LED array of an embodiment；
Fig. 3 is the abosrption spectrogram of 1mg/mL hemoglobin solutions；
Fig. 4 is the abosrption spectrogram of oxyhemoglobin and reduced hemoglobin；
Fig. 5 is three LED array light-source systems；
Fig. 6 is the arrangement architecture figure of the photonic crystal of an embodiment；
Fig. 7 is SiO2Refractive index-wavelength curve；
Fig. 8 is TiO2Refractive index-wavelength curve；
Fig. 9 is KTaO3Refractive index-wavelength curve；
Figure 10 is not introduce KTaO3Electric field-wavelength curve of the photonic crystal of defect；
Figure 11 is doped with 160nm thickness KTaO3Electric field-wavelength curve of Defect Photonic Crystal；
Figure 12 is doped with 90nm thickness KTaO3Electric field-wavelength curve of Defect Photonic Crystal；
Figure 13 is doped with 250nm thickness KTaO3Electric field-wavelength curve of Defect Photonic Crystal；
Photon crystal current field-wavelength curve when Figure 14 is A=0.5；
Photon crystal current field-wavelength curve when Figure 15 is A=1；
Photon crystal current field-wavelength curve when Figure 16 is A=1.5；
Photon crystal current field-wavelength curve when Figure 17 is A=1.8；
Photon crystal current field-wavelength curve when Figure 18 is A=2；
Photon crystal current field-wavelength curve when Figure 19 is A=2.5；
Figure 20 is the structural schematic diagram of the signal processing module of an embodiment；
Figure 21 is noiseless receiving unit output signal AC compounent (500uV/Div)；
Figure 22 is that noise Rx element output signal AC compounent (500uV/Div) is added；
Figure 23 is that noise DC component is added to export result (2V/Div)；
Figure 24 is AC compounent output result (1V/Div) that noise and direct current biasing is added；
Figure 25 is the structural schematic diagram of the ring-shape pulse blood oxygen instrument of an embodiment；
Figure 26 is the structural schematic diagram at another visual angle of ring-shape pulse blood oxygen instrument shown in Figure 25.
Specific embodiment
In order to be more clear the objectives, technical solutions, and advantages of the present invention, with reference to the accompanying drawings and embodiments, to this hair
It is bright to be further elaborated.It should be appreciated that the specific embodiments described herein are merely illustrative of the present invention, and do not have to
It is of the invention in limiting.
As shown in Figure 1, the BOLD contrast 100 of an embodiment includes light source 110, photon crystal 1 20,130 and of optical detector
Data processing module 140.
Light source 110 includes the LED array of three transmitting different wave length optical signals.Three LED arrays distinguish launch wavelength and are
The optical signal of 650nm, 805nm and 930nm.Using LED array as light source, requirement of the system to LED stability can be reduced,
And improve accuracy of measurement.
Photon crystal 1 20 is set to 130 front of optical detector, and the optical signal that light source 110 emits after photon crystal 1 20 by entering
It is incident upon optical detector 130.The photonic crystal of specific structure can select frequency.
Optical detector 130 converts optical signals to current signal for detecting the optical signal for being incident to its surface.
Data processing module 140 and optical detector 130 connect, and data processing module 140 is for receiving the hair of optical detector 130
The current signal sent, and current signal is handled to obtain oximetry data.
It is special to can use the selection of its frequency by the way that photon crystal 1 20 is arranged before optical detector 130 for above-mentioned BOLD contrast 100
Property filtering be not belonging to three LED arrays used wave band light, reduce influence of the external environmental light to measurement result, tie detection
Fruit is more accurate.
The light source 110 of above-mentioned BOLD contrast 100 is designed with the following method.
(1) selection of light source type
Oximetry system is based on the principle of absorption of light, should select suitable light source in measuring system.It please refers to
Fig. 2, light source 110 use LED array.The advantage that light source 110 has processing technology more mature, cheap using LED array.
In one embodiment, three LED arrays are set in flexible substrate.Flexible substrate can be poly- phthalic acid
Glycol ester (PET) film.Three LED arrays are integrated in PET film, can reach the mesh of flexible fitting human body
's.PET film can be obtained using pulsed laser deposition.This method is to be banged using short-pulse laser some substances
It hits, the species precipitate bombarded is in substrate, it is possible thereby to prepare the film with specific function.
Compared to light source in traditional BOLD contrast in such a way that a wavelength corresponds to single source, traditional light source mode
It is higher to the stability and power requirement of LED.The light source 110 of above-mentioned BOLD contrast 100, using the corresponding LED of a wavelength
Array, i.e., multiple LED light sources reduce the requirement of the power and stability to each LED light source, and measure and covered
Area increases, so that measurement can more reflect the time of day of tissue.
(2) optical source wavelength selects
Oximetry is carried out using light, the wavelength selection for detecting light is most important.When selecting the wavelength of light, it should guarantee non-
Probe portion cannot bring a large amount of interference, guarantee there is apparent discrimination to oxyhemoglobin and reduced hemoglobin again,
Signal is handled convenient for collecting.Meanwhile the light by choosing three kinds of wavelength is detected, and system accuracy can be improved.
Firstly, the environment locating to measurement is analyzed.It uses phosphate buffer (PBS) as solvent, has prepared several groups
The hemoglobin solutions of various concentration.Fig. 3 is the absorption spectrum of 1mg/mL hemoglobin solutions.It can be seen from the figure that blood red
Protein solution nearby has more apparent absorption peak on frequency band relatively at 275nm, 404nm, 501nm, 632nm respectively,
In, strongest peak is absorbed present in 404nm.Therefore the light wave that avoid 200nm~450nm wave band as far as possible, because of ring at this time
Border is too strong to the absorption of detection light, can reduce signal-to-noise ratio, increases the difficulty of light-receiving and signal processing.
Then, oxyhemoglobin and reduced hemoglobin are analyzed.Fig. 4 is that oxyhemoglobin and reduction are blood red
The absorption spectrum of albumen.Two kinds of hemoglobins are significantly different to the absorption of light as seen from the figure.In order to reduce tissue to measurement accuracy
Influence, when selecting optical wavelength, both both required to be greater than non-blood tissue, such as bone, muscle etc. to the absorption coefficient of light, again
Cannot make through light it is faint be difficult to detect.Therefore, when light is near 650nm, oxyhemoglobin and reduced hemoglobin
Approximate maximum to the absorption coefficient difference of light, when blood oxygen saturation difference, blood is most sensitive to the wavelength light Change of absorption, therefore,
Select wavelength for the LED array light source of 650nm.In view of LED light spectrum has certain width, the wavelength of selection cannot too phase
Closely and the difference of absorptivity, the LED array light source of 930nm wavelength is selected.Meanwhile it being derived according to langbobier law
During blood oxygen saturation, have a wavelength is equal to the absorption coefficient of the two so that measurement has preferable linear, You Tuke
Knowing should select near 805nm, therefore, select wavelength for the LED array light source of 805nm.
(3) light source luminescent timing is arranged
During Oximetry, since we will obtain the signal of three kinds of wavelength light sources, so must be to the hair of light source
Light sequential is controlled.In one embodiment, the lighting timings of the LED array of three kinds of wavelength are as shown in Figure 5.That is three kinds of wavelength
LED array light period it is consistent, duty ratio is consistent, and initial phase is different, and initial phase difference meets same time point cannot
There are two types of and two or more wavelength LED shine, while for guarantee aura effect on measurement without influence, as shown, remaining
Certain half-light time (shining without LED array).
In one embodiment, the luminous frequency of the LED array of three kinds of wavelength is 100-200Hz, and measurement can be improved
Response speed.The frequency of human pulse beating is about 0.75-3Hz, is much larger than by the way that the luminous frequency of LED array to be set to
The frequency of human pulse beating, therefore in LED array fluorescent lifetime, the uptake of heartbeat bring light can be neglected
Change.The signal that this timing control receives optical detector is the mixed signal of a multiple wavelength superpositions, but can
Signal separator to be come out by subsequent signal processing.
The case where being slower than pulse beat cycles, traditional timing Design are set by LED luminous frequency compared to traditional
The corresponding signal of each wavelength can be directly obtained, but big degree increases the response time simultaneously, theoretically analyzes, if often
The light source luminescent frequency of a wavelength is set to 0.5Hz, and pulse Beating Rate is 1Hz, along with different LED light on and off need one in the process
Fixed half-light time, three wavelength completion one-shot measurement periods probably need 9-10 beat cycles, affect whole measurement system
The response speed of system.And in the present embodiment, the timing control of the LED array of above three wavelength allows us at 2-3
It is measured in pulse beat cycles as a result, improving the response speed of total system.Therefore, shining by design LED array
Frequency is greater than human pulse Beating Rate, in signal processing again by the Signal separator of the light of different wave length, compared to tradition
Design LED luminous frequency be less than human pulse Beating Rate the case where, measurement the response time it is shorter.
The photon crystal 1 20 of above-mentioned BOLD contrast 100 is designed with the following method.
By the way that photon crystal 1 20 is arranged in the front of optical detector 130, some unrelated light can be filtered, measurement is done
It disturbs.Optical detector 130 can be photodiode detector.Photonic crystal can be simulated using CST, intend finding in 650-
950nm (LED wave band) has smooth passband and suitably absorbs the photonic crystal of the light of remaining wave band.
In one embodiment, substance with differing dielectric constant of the photon crystal 1 20 including periodic arrangement, and light
There is at least one of point defect, line defect or planar defect in sub- crystal 120.Specifically, periodic arrangement has difference
The substance of dielectric constant can be the substance of two kinds of differing dielectric constants of One Dimension Periodic arrangement.
Photon crystal 1 20 is the substance of the periodic structure of differing dielectric constant, and light wave meets Mike in conduction wherein
This Wei equation group provides initial value and boundary condition and some necessary parameters, such as refractive index, conductivity, opposite dielectric
Constant etc., it can the general solution for deriving maxwell equation group, by the uniqueness of electromagnetic field, it can obtain entirely studying model
The distribution situation for the field enclosed.By utilizing COMSOL software, can be constructed different with the periodic structure of simulated photons crystal 120
Defect can achieve control and pass through the purpose of the frequency of light wave such as point defect, line defect, planar defect.
The substance of two kinds of differing dielectric constants of One Dimension Periodic arrangement can be right in the case where introducing different defects
The light of visible light wave range near infrared band has certain control effect.In the present embodiment, referring to FIG. 6, photonic crystal
120 include the SiO of One Dimension Periodic arrangement2Layer and TiO2Layer, wherein SiO2Layer and TiO2Layer alternate intervals arrangement, photonic crystal
In doped with one layer of KTaO3Layer.SiO2、TiO2And KTaO3With differing dielectric constant.
Due to SiO2、TiO2And KTaO3Three kinds of substances have different refractive index to the light of different wave length, so by consulting
Refractive index table can be in the hope of the corresponding refractive index of different wave length by constructing three interpolating functions, and Fig. 7, Fig. 8 and Fig. 9 are respectively
SiO2、TiO2And KTaO3Refractive index to the functional relation image of different wave length, can be called when being simulated.
In one embodiment, single layer SiO2Thickness is set as 90nm, single layer TiO2Thickness is set as 160nm.Lattice constant
A=250nm, boundary are scattering boundary condition.It is to measure the physical quantity of light intensity with the electric field strength of electromagnetic wave, research range is
3.0e14Hz-1.0e15Hz (corresponding wavelength range are as follows: 300nm-1000nm).
1, influence of the doping different-thickness impurity to the light passing ability of photonic crystal.
Figure 10 to Figure 13 does not introduce KTaO respectively3160nm thickness KTaO is added in the case where defect390nm is added in defect
Thickness KTaO3250nm thickness KTaO is added in defect3Analog result after defect.
Pass through comparison, it has been found that the doping KTaO of different-thickness3The forbidden band of 500nm to 600nm can be caused different degrees of
Widen, which shows that the design of the photonic crystal has certain selectivity for frequency, can play certain
Filter effect.Be selected as 650nm, 805nm and 930nm based on optical source wavelength, the design of photonic crystal should selection this three
The percent of pass of a wavelength is larger, therefore, chooses the KTaO of doping thickness 250nm3Layer.Then, KTaO is adulterated in selection3The thickness of layer
On the basis of degree is 250nm, fixed lattice constant is studied, SiO is changed2With TiO2Influence of the thickness proportion to simulation.
2、SiO2With TiO2Influence of the different-thickness ratio to photonic crystal light passing ability.
By changing TiO2And SiO2Thickness proportion carry out analog simulation, single layer TiO is represented with A2The thickness of layer is than upper list
Layer SiO2The thickness of layer, it is respectively 0.5,1,1.5,1.8,2.0,2.5 progress theoretical modeling that we, which choose A,.Thickness ratio A is respectively
0.5,1,1.5,1.8,2.0,2.5 analog result is respectively as shown in Figure 14 to Figure 19.
It can be found that the increase with thickness proportion from Figure 14 to Figure 19, the 500nm- of photonic crystal when A=0.5
The passband of 700nm broadens and red shift, and in A=2, which becomes 650nm-950nm.At the same time, the increasing of thickness proportion A
Add the forbidden band also brought near a 550nm, which first increases and reduce afterwards, in A=1.8 or so with the increase of A
Reach maximum, is 100nm, range 500nm-600nm.At the same time, the variation of A also makes the forbidden band near 400nm broaden,
In A=2.5, forbidden bandwidth substantially 50nm.The wavelength of light source based on selection be 650nm, 805nm and 930nm, therefore,
Preferably, in photonic crystal, single layer TiO2Layer and single layer SiO2Layer thickness proportion is 1.8~2, KTaO3Layer with a thickness of 250nm.
Certain unrelated light can not only be filtered in this way, and it is larger that photonic crystal can be made to have at the LED array of three wavelength
Percent of pass.
In one embodiment, data processing module 140 includes signal processing module, and signal processing module is used for electric current
Signal is converted to voltage signal and is handled and be sent to computer, and computer calculates oximetry data according to voltage signal.Tool
Body, current signal is converted to the operation that voltage signal is handled by signal processing module are as follows: signal processing module is by electric current
Signal amplifies filtering, direct current biasing and the processing of NAND gate reverse phase after being converted to voltage signal.
In one embodiment, as shown in figure 20, signal processing module includes sequentially connected receiving unit, preposition amplification
Unit, the first high pass filter unit, the first low-pass filter unit, secondary amplifying unit, the second high pass filter unit, the second low pass
Filter unit and direct current biasing unit, and the NAND gate rp unit connected with pre-amplifier unit.
The current signal received is become voltage signal while amplified by receiving unit, and in order to guarantee at signal
Filter circuit in reason module not will cause the distortion of photodiode current signal, it should control and receive the cutoff frequency of unit
Much higher than the frequency of signal light.Enter pre-amplifier unit by the voltage signal that receiving unit obtains, since signal is more micro-
It is weak, therefore circuit is constructed using the higher amplifier of input impedance.The gain of pre-amplifier unit is 51.Circuit can be enhanced
Resistance to polarizability, prevent enter cut-off and saturation state.Pre-amplification circuit output signal is divided into two-way, wherein final all the way
Direct current signal is obtained, another way obtains AC signal.Exchange branch should weaken DC component as far as possible, thus design the first high pass
Filter unit, while cutoff frequency design can not be excessively high, otherwise heart rate signal is easy to be filtered, can not be too low, it will lead to
DC filtering is undesirable.It is finally 1.02 by the passband gain design of the first high pass filter unit, cutoff frequency is designed as
0.75Hz.Since circuit system has high frequency noise everywhere, thus first low-pass filter unit is also needed to be filtered out.Choosing
The low pass gain for taking the first low-pass filter unit is 1.58, cutoff frequency 20Hz.Second high pass filter unit and the second low pass
Filter unit is consistent with the first low-pass filter unit parameter with the first high pass filter unit respectively.Since there are negative electricity for AC signal
Pressure, and AD conversion necessarily requires as positive voltage, therefore also needs a direct current biasing unit, it is straight to being superimposed one on AC signal
Galvanic electricity pressure, allowing to normal conversion is digital signal.Direct current signal is negative pressure signal, it is therefore desirable to a NAND gate rp unit
It is changed into positive voltage, digital processing can be carried out.
Analog simulation result is as follows:
The AC compounent of not plus noise, receiving unit output signal is as shown in figure 21.
After noise is added, the AC compounent of receiving unit output signal is as shown in figure 22.
Final DC component output result is as shown in figure 23.
The AC compounent of final addition direct current biasing is as shown in figure 24.
Nowadays flexible circuit board machining process is increasingly mature, to reach ring-shape, it is necessary to flexible circuit is used, it can will be whole
Body circuit system is integrated on flexible circuit board, and the common processing technology of flexible circuit board has laser bombardment method and chemical deposition
Deng.
In one embodiment, data processing module 140 further includes bluetooth module, and bluetooth module and signal processing module connect
It connects, bluetooth module is used for that treated that voltage signal is sent to computer by signal processing module.
In one embodiment, bluetooth module can be CC2541 bluetooth module.CC2541 carries 12 sampling precisions
ADC, reference voltage oneself can be arranged, meet 4.0 agreement of bluetooth, can be sent to by signal sampling and by obtained voltage data
Computer recycles matlab to be handled, and calibrates.Traditional BOLD contrast is usually to obtain blood first with single-chip microcontroller processing signal
Oxygen data recycle single-chip microcontroller to control bluetooth module, send data to computer or cloud, therefore circuit is complex,
BOLD contrast volume is larger, is not able to satisfy portable, long periods of wear requirement needed for every-day medical monitor, and large-scale mould
Quasi- circuit will bring system noise.And the design of above-mentioned BOLD contrast 100 can not be handled via single-chip microcontroller, but directly by signal
It is sent to computer, data processing is carried out on computers and obtains oximetry data, largely reduce circuit complexity, subtract
The volume and analog circuit scale for having lacked measuring system increase brought noise.
Please refer to Figure 25, the ring-shape pulse blood oxygen instrument 200 of an embodiment, including ring support, light source 210, photon
Crystal (not shown), optical detector 230 and data processing module.
Ring support includes the first mounting portion 242, the second mounting portion 244, first elastic webbing 246 and second elastic webbing 248.
First mounting portion 242 and the second mounting portion 244 are oppositely arranged.
One end of first elastic webbing 246 is connected with one end of the first mounting portion 242, the other end of first elastic webbing 246 and
One end of second mounting portion 244 connects.
One end of second elastic webbing 248 is connected with the other end of the first mounting portion 242, the other end of second elastic webbing 248
It is connected with the other end of the second mounting portion 244.
Light source 210 is set in the first mounting portion 242, and the front of light source 210 is equipped with first through hole 241, and the light of light source 210 is believed
Number be emitted through first through hole 241, light source 210 includes three LED arrays, three LED arrays difference launch wavelengths be 650nm,
The optical signal of 805nm and 930nm.
Photonic crystal and optical detector 230 are set in the second mounting portion 244, before photonic crystal is set to optical detector 230
Side, the front of photonic crystal are equipped with the second through-hole 243, and the optical signal that light source 210 emits is incident to photon by the second through-hole 243
Crystal, the optical signal that light source 210 emits is by being incident to optical detector 230 after photonic crystal.
Optical detector 230 converts optical signals to current signal for detecting the optical signal for being incident to its surface.
Data processing module and optical detector 230 connect, and data processing module is used to receive the electricity of the transmission of optical detector 230
Signal is flowed, and current signal is handled to obtain oximetry data.
It please also refer to Figure 26, the first mounting portion 242 includes the first water absorption layer 2422, the first water barrier stacked gradually
2424, first circuit layer 2426 and the first protective layer 2428, light source 210 are set to first circuit layer 2426, and first through hole 241 runs through
First water absorption layer 2422 and the first water barrier 2424.
Second mounting portion 244 includes the second water absorption layer 2442, the second water barrier 2444, the second circuit layer stacked gradually
2446 and second protective layer 2448, photonic crystal and optical detector 230 be set to the second circuit layer 2446, the second through-hole 243 passes through
Wear the second water absorption layer 2442 and the second water barrier 2444.
First water absorption layer 2422 and the second water absorption layer 2442 are oppositely arranged.
The both ends of first elastic webbing 246 are solid with one end of the first protective layer 2428 and one end of the second protective layer 2448 respectively
Fixed connection, the both ends of second elastic webbing 248 are another with the other end of the first protective layer 2428 and the second protective layer 2448 respectively
End is fixedly connected.Both ends and the first protective layer 2428 and second protection at the both ends, second elastic webbing 248 of first elastic webbing 246
The junction of layer 2448 is all made of button connection, shares eight buttons, and six of them is fixed button, and two are that can detain button,
Facilitate wearing, while ensure that the collimation of optical path.
Light source 210, photonic crystal, optical detector 230 and data processing module structure, parameter and above-mentioned BOLD contrast 100
Light source 110, photon crystal 1 20, optical detector 130 and data processing module 140 it is identical, details are not described herein.
Since finger needs to clean before measuring, it cannot be guaranteed that the moisture on finger is wiped clean completely, in order to reduce moisture
Influence to measurement, above-mentioned ring-shape pulse blood oxygen instrument 200 are close to the first water absorption layer of skin design 2422 and second by design
Water absorption layer 2442, can be clean by position moisture absorption to be measured.While in order to construct dark room conditions, 2422 He of the first water absorption layer
Second water absorption layer 2442 causes deformation using the longitudinal pulling force of elastic webbing using more soft material, makes environment light can not be into
Enter optical path.Moisture enters circuit part damage circuit in order to prevent, designs the first water proof on the first water absorption layer 2422
Layer 2424, designs the second water barrier 2444 on the second water absorption layer 2442.In the first mounting portion 242 and the second mounting portion 244
It opens up first through hole 241 and the second through-hole 243 exposes optical path, the first mounting portion 242 and the second mounting portion 244 is made not to absorb survey
Amount light and signal light reduce its intensity.First circuit layer 2426 and the second circuit layer 2446 are made of flexible material, and by LED
Array and optical detector 230 are integrated in respectively on two circuit layers, play fixed function.First protective layer 2428 and second is protected
The intensity of sheath 2448 is higher, can share two elastic webbing bring lateral pulls, prevent circuit modifications, influences circuit effect
Fruit, while preventing the external world from bringing damage to precision circuit layer.Entire ring-shape pulse blood oxygen instrument 200 has adaptivity, faces
The finger of different size can produce ideal darkroom, and guarantee the collimation of optical path, while being convenient for carrying and measuring, also
Preferable stability.
Traditional portable BOLD contrast is finger clip-type, and due to personal physical difference, the elongated short difference of thick fingers may
Will lead to cannot construct complete dark room conditions, enter bias light in optical path, interfere to measurement result, cannot be accurate
Data.Above-mentioned ring-shape pulse blood oxygen instrument 200 has adaptive by connection the first mounting portion of band connection and the second mounting portion
Ying Xing fully takes into account individual sex differernce, reduces influence of the environment light to system.Above-mentioned ring-shape pulse blood oxygen instrument 200, body
Small, the comfortable wearing of product, can wear for a long time, be easy to connect with mobile phone, computer, realize the long-term monitoring of blood oxygen, and by environment light
Influence it is small, measure it is more acurrate.
The above is only a preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art
Member, various improvements and modifications may be made without departing from the principle of the present invention, these improvements and modifications also should be regarded as
Protection scope of the present invention.
Claims (10)
1. a kind of BOLD contrast, which is characterized in that including light source, photonic crystal, optical detector and data processing module；
The light source includes the LED array of three transmitting different wave length optical signals；
The photonic crystal is set in front of the optical detector, and the optical signal of the light source transmitting after the photonic crystal by entering
It is incident upon the optical detector；
The optical signal is converted to current signal for detecting the optical signal for being incident to its surface by the optical detector；
The data processing module is connected with the optical detector, and the data processing module is for receiving the optical detector hair
The current signal sent, and handled the current signal to obtain oximetry data.
2. BOLD contrast as described in claim 1, which is characterized in that three LED arrays difference launch wavelengths be 650nm,
The optical signal of 805nm and 930nm.
3. BOLD contrast as described in claim 1, which is characterized in that the data processing module includes signal processing module, institute
It states signal processing module and is handled and be sent to computer, the calculating for the current signal to be converted to voltage signal
Machine calculates oximetry data according to the voltage signal.
4. BOLD contrast as claimed in claim 3, which is characterized in that the signal processing module is converted to the current signal
The operation that voltage signal is handled are as follows:
The signal processing module current signal is converted to amplify after voltage signal filtering, direct current biasing and with it is non-
Door reverse phase processing.
5. BOLD contrast as claimed in claim 3, which is characterized in that the data processing module further includes bluetooth module, described
Bluetooth module is connected with the signal processing module, and the bluetooth module is used for the signal processing module treated voltage
Signal is sent to computer.
6. BOLD contrast as described in claim 1, which is characterized in that the photonic crystal includes that having for periodic arrangement is different
The substance of dielectric constant, and there is at least one of point defect, line defect or planar defect in the photonic crystal.
7. BOLD contrast as claimed in claim 6, which is characterized in that the photonic crystal includes the SiO of One Dimension Periodic arrangement2
Layer and TiO2Layer, wherein SiO2Layer and TiO2Layer alternate intervals arrange, doped with one layer of KTaO in the photonic crystal3Layer.
8. BOLD contrast as described in claim 1, which is characterized in that the signal processing module includes that sequentially connected reception is single
Member, pre-amplifier unit, the first high pass filter unit, the first low-pass filter unit, secondary amplifying unit, the second high-pass filtering list
Member, the second low-pass filter unit and direct current biasing unit, and the NAND gate rp unit connected with the pre-amplifier unit.
9. a kind of ring-shape pulse blood oxygen instrument, which is characterized in that including ring support, light source, photonic crystal, optical detector sum number
According to processing module；
The ring support includes the first mounting portion, the second mounting portion, first elastic webbing and second elastic webbing；
First mounting portion and second mounting portion are oppositely arranged；
One end of the first elastic webbing is connected with one end of first mounting portion, the other end of the first elastic webbing and institute
State one end connection of the second mounting portion；
One end of the second elastic webbing is connected with the other end of first mounting portion, the other end of the second elastic webbing and
The other end of second mounting portion connects；
The light source is set in first mounting portion, and the front of the light source is equipped with first through hole, the optical signal of the light source
It is emitted through the first through hole, the light source includes the LED array of three transmitting different wave length optical signals；
The photonic crystal and the optical detector are set in second mounting portion, and the photonic crystal is visited set on the light
It surveys in front of device, the front of the photonic crystal is equipped with the second through-hole, and the optical signal of the light source transmitting passes through second through-hole
It is incident to the photonic crystal, the optical signal of the light source transmitting is by being incident to the optical detector after the photonic crystal；
The optical signal is converted to current signal for detecting the optical signal for being incident to its surface by the optical detector；
The data processing module is connected with the optical detector, and the data processing module is for receiving the optical detector hair
The current signal sent, and handled the current signal to obtain oximetry data.
10. ring-shape pulse blood oxygen instrument as claimed in claim 9, which is characterized in that first mounting portion includes successively layer
Folded the first water absorption layer, the first water barrier, first circuit layer and the first protective layer, the light source are set to the first circuit layer,
The first through hole runs through first water absorption layer and first water barrier；
Second mounting portion includes the second water absorption layer stacked gradually, the second water barrier, the second circuit layer and the second protective layer,
The photonic crystal and the optical detector are set to the second circuit layer, and second through-hole runs through second water absorption layer
With second water barrier；
First water absorption layer and second water absorption layer are oppositely arranged；
The one end of the both ends of the first elastic webbing respectively with one end of first protective layer and second protective layer is fixed
Connection, the both ends of the second elastic webbing other end with the other end of first protective layer and second protective layer respectively
It is fixedly connected.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810192258.4A CN110236563A (en) | 2018-03-08 | 2018-03-08 | A kind of BOLD contrast and ring-shape pulse blood oxygen instrument |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810192258.4A CN110236563A (en) | 2018-03-08 | 2018-03-08 | A kind of BOLD contrast and ring-shape pulse blood oxygen instrument |
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| CN110236563A true CN110236563A (en) | 2019-09-17 |
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| CN201810192258.4A Pending CN110236563A (en) | 2018-03-08 | 2018-03-08 | A kind of BOLD contrast and ring-shape pulse blood oxygen instrument |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111466922A (en) * | 2020-05-14 | 2020-07-31 | 中科搏锐（北京）科技有限公司 | Adaptive blood oxygen signal acquisition probe, device and method based on near infrared blood oxygen detection |
-
2018
- 2018-03-08 CN CN201810192258.4A patent/CN110236563A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111466922A (en) * | 2020-05-14 | 2020-07-31 | 中科搏锐（北京）科技有限公司 | Adaptive blood oxygen signal acquisition probe, device and method based on near infrared blood oxygen detection |
| CN111466922B (en) * | 2020-05-14 | 2023-11-24 | 中科搏锐（北京）科技有限公司 | Self-adaptive blood oxygen signal acquisition probe, device and method based on near infrared blood oxygen detection |
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Application publication date: 20190917 |