CN110236484B - Large-view-field fundus high-resolution imaging system - Google Patents

Large-view-field fundus high-resolution imaging system Download PDF

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CN110236484B
CN110236484B CN201910579407.7A CN201910579407A CN110236484B CN 110236484 B CN110236484 B CN 110236484B CN 201910579407 A CN201910579407 A CN 201910579407A CN 110236484 B CN110236484 B CN 110236484B
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lens
imaging
radius
curvature
reflecting mirror
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CN110236484A (en
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伍雁雄
郭智元
张宏炫
廖锤
李建聪
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Foshan University
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Foshan University
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B3/00Apparatus for testing the eyes; Instruments for examining the eyes
    • A61B3/10Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
    • A61B3/12Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for looking at the eye fundus, e.g. ophthalmoscopes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B3/00Apparatus for testing the eyes; Instruments for examining the eyes
    • A61B3/10Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
    • A61B3/14Arrangements specially adapted for eye photography

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medical Informatics (AREA)
  • Biophysics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Eye Examination Apparatus (AREA)

Abstract

The invention discloses a large-view-field fundus high-resolution imaging system which comprises a omentum objective lens group, a focusing mirror, a reflecting mirror, an imaging lens group and an imaging surface, wherein emergent light of human eyes sequentially passes through the omentum objective lens group, the focusing mirror, the reflecting mirror and the imaging lens group, the imaging lens group images the emergent light of the reflecting mirror on the imaging surface, and the reflecting mirror is annular hollow. The system has a simpler structure, realizes high-quality imaging, only allows imaging light to pass through due to conjugation of the reflecting mirror and the pupil of the human eye, avoids reflected light of the omentum objective lens group from entering an imaging light path, and effectively inhibits parasitic light.

Description

Large-view-field fundus high-resolution imaging system
Technical Field
The invention relates to the technical field of fundus medical imaging, in particular to a large-view-field fundus high-resolution imaging system.
Background
The fundus camera is a medical instrument which illuminates fundus through an illumination system, images fundus on a photosensitive chip of a CCD or CMOS camera through an imaging system, and further acquires fundus images. The fundus camera is used for checking whether fundus is abnormal, such as retina, optic disc, vascularity and the like, and has important significance for diagnosis and prevention of ophthalmic diseases and vascular related diseases. Large fundus camera equipment is expensive and portable, requires specialized medical staff to operate, and in order to popularize fundus examination, a small-sized, low-cost and easy-to-operate handheld fundus camera is required.
Patent CN108309228A implements a portable fundus camera with a full field angle of 30 °, and a total system length of not more than 250 mm. The fundus camera imaging system consists of an eye objective lens and an imaging objective lens, the light path is simpler, but only a fundus detection view field of 30 degrees is needed, fundus information is less to acquire, and a doctor is difficult to accurately judge the illness state.
Patent CN104224109a realizes a fundus camera combined with OCT system, which can be used to obtain good OCT tomographic images of ocular fundus of different refraction, but its system is quite complex, portability is poor, and it is not suitable for popularization of fundus examination.
The fundus camera optical system in the prior art has the advantages of smaller detection full view angle, less fundus information, complex structure, poor portability, inapplicability to popularization of fundus examination, and low energy utilization rate due to the fact that a part of the system is added with the polarization beam splitter prism.
Disclosure of Invention
The invention provides a large-view-field fundus high-resolution imaging system which is simple in structure and suitable for fundus examination.
The invention solves the technical problems as follows:
the large-view-field fundus high-resolution imaging system comprises a omentum objective lens group, a focusing mirror, a reflecting mirror, an imaging lens group and an imaging surface, wherein emergent light of human eyes sequentially passes through the omentum objective lens group, the focusing mirror, the reflecting mirror and the imaging lens group, the imaging lens group images the emergent light of the reflecting mirror on the imaging surface, and the reflecting mirror is annular hollow.
As a further improvement of the above technical solution, the web objective group includes a first lens, a second lens and a third lens.
As a further improvement of the above technical solution, the first lens and the second lens form a first double cemented lens, and the third lens is an aspheric single lens.
As a further improvement of the above technical solution, the radius of curvature of the first lens is-124.337 mm;
the curvature radius of the front surface of the second lens is-24.123 mm, and the curvature radius of the rear surface of the second lens is-71.562 mm;
the radius of curvature of the front surface of the third lens is 40.025mm, and the radius of curvature of the rear surface is-95.331 mm.
As a further improvement of the above technical solution, the imaging lens group includes a fourth lens, a fifth lens, a sixth lens, a seventh lens, and an eighth lens.
As a further improvement of the above technical solution, the fourth lens and the fifth lens form a double-split lens, the seventh lens and the eighth lens form a second double-cemented lens, and the sixth lens is a single lens.
As a further improvement of the above technical solution, the radius of curvature of the front surface of the fourth lens is 91.324mm, and the radius of curvature of the rear surface is 52.348mm;
the curvature radius of the front surface of the fifth lens is-245.924 mm, and the curvature radius of the rear surface of the fifth lens is 48.468mm;
the curvature radius of the front surface of the sixth lens is 85.364mm, and the curvature radius of the rear surface of the sixth lens is-114.672 mm;
the radius of curvature of the seventh lens is 29.068mm;
the radius of curvature of the front surface of the eighth lens is-15.637 mm, and the radius of curvature of the rear surface is 31.268mm.
As a further improvement of the above technical solution, the inner radius of the reflecting mirror is 5mm, and the outer radius of the reflecting mirror is 12mm.
As a further improvement of the above technical solution, the focusing lens is a thick meniscus lens.
As a further improvement of the above technical solution, the imaging surface is a photosensitive chip of a CCD camera or a CMOS camera.
The beneficial effects of the invention are as follows: the system has a simpler structure, realizes high-quality imaging, only allows imaging light to pass through due to conjugation of the reflecting mirror and the pupil of the human eye, avoids reflected light of the omentum objective lens group from entering an imaging light path, and effectively inhibits parasitic light.
Drawings
In order to more clearly illustrate the technical solutions in the embodiments of the present invention, the drawings that are required to be used in the description of the embodiments will be briefly described below. It is evident that the drawings described are only some embodiments of the invention, but not all embodiments, and that other designs and drawings can be obtained from these drawings by a person skilled in the art without inventive effort.
FIG. 1 is a schematic diagram of a configuration of an embodiment imaging system;
FIG. 2 is a graph of MTF for an embodiment imaging system;
FIG. 3 is a point column diagram of an embodiment imaging system;
fig. 4 is a light ray fan diagram of an embodiment imaging system.
Detailed Description
The conception, specific structure, and technical effects produced by the present invention will be clearly and completely described below with reference to the embodiments and the drawings to fully understand the objects, features, and effects of the present invention. It is apparent that the described embodiments are only some embodiments of the present invention, but not all embodiments, and that other embodiments obtained by those skilled in the art without inventive effort are within the scope of the present invention based on the embodiments of the present invention. In addition, all connection relationships mentioned herein do not refer to direct connection of the components, but rather, refer to a connection structure that may be better formed by adding or subtracting connection aids depending on the particular implementation. The technical features in the invention can be interactively combined on the premise of no contradiction and conflict.
Embodiment 1, referring to fig. 1, a large-field fundus high-resolution imaging system includes a omentum objective lens 100, a focusing mirror 200, a reflecting mirror 300, an imaging lens 400 and an imaging plane 500 sequentially arranged from front to back, wherein the emergent light of human eyes sequentially passes through the omentum objective lens 100, the focusing mirror 200, the reflecting mirror 300 and the imaging lens 400, the imaging lens 400 images the emergent light of the reflecting mirror 300 on the imaging plane 500, and the reflecting mirror 300 is annular hollow.
In this embodiment, a human eye model 600 is provided, the human eye model 600 is disposed in front of the omentum objective lens group 100, and the human eye model 600 is a standard human eye model of Gullstrand-Le Grand, which can simulate human eye aberration.
The omentum objective lens group 100 is used for receiving light rays emitted by the eyeground of a human eye illuminated by the illumination system, the focusing lens 200 is used for compensating myopia or hyperopia with abnormal refraction of the human eye, the included angle between the reflecting mirror 300 and the main optical axis is 45 degrees, and the imaging lens group 400 is used for imaging an eyeground image on the imaging surface 500.
The illumination system is a conventional illumination system and is mainly used for illuminating the eyeground of human eyes.
The illumination system illuminates the eyeground of the human eye, the eyeground is used as a secondary light source to emit emergent light, and the emergent light is emitted close to parallel light after passing through glass body, crystalline lens, pupil, anterior chamber, cornea and other human eye structures with completely different refractive indexes and thicknesses. The pupil is used as an aperture diaphragm of the fundus imaging optical system, the diameter phi=2mm of the imaging light beam passing through the pupil is limited, and the pupil is not interfered with an annular light spot formed at the pupil of the human eye by the illumination system.
The included angle between the maximum field angle of the emergent light of the human eye model 600 and the main optical axis is close to +/-30 degrees, the emergent light reaches the omentum objective lens group 100 after passing through a working distance of about 24mm, the lens diameter of the omentum objective lens group 100 is larger than 40mm, and the emergent light is imaged once after passing through the omentum objective lens group 100, and the imaging is not carried out for the image quality.
The outgoing light of the omentum objective lens assembly 100 passes through a focusing lens 200, and the focusing lens 200 is used for compensating myopia or hyperopia with abnormal refraction of human eyes. The variable quantity is set by the focusing lens 200 and the net film objective lens group 100 together, the heights of the light rays with different view fields on the reflecting mirror 300 are controlled, the rear working distance of the focusing lens 200 is more than 30mm, and the requirement for placing the reflecting mirror 300 is met.
The light rays are focused by the focusing mirror 200 and then are emitted to the reflecting mirror 300, the light rays pass through the hollow part of the reflecting mirror 300 and are emitted into the imaging lens group 400 as imaging light rays, and after passing through the imaging lens group 400, the imaging lens group 400 images the imaging light rays carrying fundus information on the imaging plane 500. The imaging light passes through the reflecting mirror 300 and then passes through a section of back working distance of about 15mm to the imaging lens group 400, the maximum lens diameter of the imaging lens group 400 is about 11mm, the maximum air interval is about 7mm, and the back working distance is about 23 mm.
The reflecting mirror 300 is annular hollow and is conjugate with the human eye model 600, and the reflecting portion prevents the reflected light of the omentum objective lens 100 from entering the imaging light path, so that stray light is effectively suppressed.
The system of the invention has a simpler structure, realizes high-quality imaging, and the reflecting mirror 300 is conjugated with the pupil of the human eye, only allows imaging light to pass through, prevents reflected light of the omentum objective lens group 100 from entering an imaging light path, and effectively inhibits parasitic light.
As a preferred embodiment, the web objective lens group 100 includes a first lens 101, a second lens 102, and a third lens 103.
As a preferred embodiment, the first lens 101 and the second lens 102 form a first biconic lens, and the third lens 103 is an aspheric single lens.
The omentum objective lens 100 is composed of a first cemented lens that is operable to eliminate chromatic aberration and an aspheric single lens that is primarily operable to eliminate some of the human eye aberrations.
As a preferred embodiment, the radius of curvature of the first lens 101 is-124.337 mm;
the radius of curvature of the front surface of the second lens 102 is-24.123 mm, and the radius of curvature of the rear surface is-71.562 mm;
the radius of curvature of the front surface of the third lens 103 is 40.025mm, and the radius of curvature of the rear surface is-95.331 mm.
As a preferred embodiment, the imaging lens group 400 includes a fourth lens 401, a fifth lens 402, a sixth lens 403, a seventh lens 404, and an eighth lens 405.
As a preferred embodiment, the fourth lens 401 and the fifth lens 402 form a double-split lens, the seventh lens 404 and the eighth lens 405 form a second double-cemented lens, and the sixth lens 403 is a single lens.
The imaging lens group 400 adopts a typical wide-angle eyepiece lens, namely a combined lens group of a double cemented lens, a single lens and a double cemented lens, as an initial structure, wherein the first double cemented lens is mainly used for balancing aberration, and the first double cemented lens used for balancing aberration is subjected to positive and negative focal power separation to correct field curvature in consideration of large field curvature of a large-field system, so as to obtain a double-separation lens, and therefore the imaging lens group 400 comprises a double-separation lens, a single lens and a second double cemented lens, wherein the single lens and the second double cemented lens form an eyepiece.
As a preferred embodiment, the radius of curvature of the front surface of the fourth lens 401 is 91.324mm, and the radius of curvature of the rear surface is 52.348mm;
the radius of curvature of the front surface of the fifth lens 402 is-245.924 mm, and the radius of curvature of the rear surface is 48.468mm;
the radius of curvature of the front surface of the sixth lens 403 is 85.364mm, and the radius of curvature of the rear surface is-114.672 mm;
the radius of curvature of the seventh lens 404 is 29.068mm;
the eighth lens 405 has a front surface radius of curvature of-15.637 mm and a rear surface radius of curvature of 31.268mm.
As a preferred embodiment, the inner radius of the reflecting mirror 300 is 5mm, and the outer radius of the reflecting mirror 300 is 12mm.
The hollow portion of the reflecting mirror 300 allows the imaging light to pass through, and the hollow portion of the reflecting mirror 300 is conjugated with the pupil of the human eye to jointly play a role in eliminating system stray light.
As a preferred embodiment, the imaging surface 500 is a photosensitive chip of a CCD camera or a CMOS camera.
The imaging plane 500 is used to absorb the imaging light transmitted through the mirror 300 and form a clear image.
As a preferred embodiment, the focusing lens 200 is a thick meniscus lens.
The focusing lens 200 is a thick meniscus lens, and is used for adjusting the abnormal diopter of human eyes, so that fundus rays can be clearly imaged on a photosensitive chip of a CCD camera or a CMOS camera to obtain fundus images, and meanwhile, the focusing lens also plays a certain role in correcting field curvature.
Referring to fig. 2, fig. 2 is an MTF graph of the present system, where the MTF graph is greater than 0.3 at the nyquist frequency 145lp/mm, and the fundus 6 μm structure can be resolved, and the average tube diameter of the retinal capillary is 6-9 μm, indicating that the present system has high fundus resolution.
Referring to fig. 3, fig. 3 is a dot column diagram of the present system, where the dot column diagram shows that the RMS radius of each field of view is smaller than 4.278 μm, which is comparable to the diffraction limit airy disk size, indicating that the present system has high image quality.
Referring to fig. 4, fig. 4 is a light ray fan diagram of the system, the maximum scaling of the light ray fan diagram is ±20 μm, which shows that the aberration of each field of view at the image plane is small, and the aberration correction capability of the system is strong.
The system realizes 55-degree large-view-field fundus imaging, increases fundus information acquisition, and is beneficial to doctors to accurately judge the illness state of patients.
The system realizes the resolution of a fundus 6 mu m structure, has high imaging quality, the MTF is greater than 0.6 at 70lp/mm, is greater than 0.3 at 145lp/mm, and has a maximum RMS radius of 4.278 mu m.
While the preferred embodiments of the present invention have been illustrated and described, the present invention is not limited to the embodiments, and various equivalent modifications and substitutions can be made by one skilled in the art without departing from the spirit of the present invention, and these are intended to be included in the scope of the present invention as defined in the appended claims.

Claims (4)

1. The high-resolution imaging system of the ocular fundus is characterized by comprising a omentum objective lens group, a focusing mirror, a reflecting mirror, an imaging lens group and an imaging surface, wherein emergent light of human eyes sequentially passes through the omentum objective lens group, the focusing mirror, the reflecting mirror and the imaging lens group, the imaging lens group images the emergent light of the reflecting mirror on the imaging surface, and the reflecting mirror is annular hollow;
the omentum objective lens group comprises a first lens, a second lens and a third lens;
the first lens and the second lens form a first double-cemented lens, and the third lens is an aspheric single lens;
the curvature radius of the first lens is-124.337 mm;
the curvature radius of the front surface of the second lens is-24.123 mm, and the curvature radius of the rear surface of the second lens is-71.562 mm;
the radius of curvature of the front surface of the third lens is 40.025mm, and the radius of curvature of the rear surface of the third lens is-95.331 mm; the imaging lens group comprises a fourth lens, a fifth lens, a sixth lens, a seventh lens and an eighth lens; the fourth lens and the fifth lens form a double-separation lens, the seventh lens and the eighth lens form a second double-gluing lens, and the sixth lens is a single lens; the curvature radius of the front surface of the fourth lens is 91.324mm, and the curvature radius of the rear surface of the fourth lens is 52.348mm;
the curvature radius of the front surface of the fifth lens is-245.924 mm, and the curvature radius of the rear surface of the fifth lens is 48.468mm;
the curvature radius of the front surface of the sixth lens is 85.364mm, and the curvature radius of the rear surface of the sixth lens is-114.672 mm;
the radius of curvature of the seventh lens is 29.068mm;
the radius of curvature of the front surface of the eighth lens is-15.637 mm, and the radius of curvature of the rear surface is 31.268mm.
2. The large field fundus high resolution imaging system according to claim 1, wherein: the inner radius of the reflector is 5mm, and the outer radius of the reflector is 12mm.
3. The large field fundus high resolution imaging system according to claim 1, wherein: the focusing lens is a thick meniscus lens.
4. The large field fundus high resolution imaging system according to claim 1, wherein: the imaging surface is a photosensitive chip of a CCD camera or a CMOS camera.
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CN114711714B (en) * 2022-06-08 2023-02-28 南京览视医疗科技有限公司 Large-view-field miniaturized fundus imaging optical system
CN115553711A (en) * 2022-10-14 2023-01-03 中国科学院苏州生物医学工程技术研究所 Self-adaptive optics and wavefront detection system based on mask modulation

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