CN110232691A - A kind of dividing method of multi-modal CT images - Google Patents
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Abstract
The invention discloses a kind of dividing methods of multi-modal CT images, comprising: selection benchmark modality images arrange a series of control points wherein;Using similarity regression model, the control point of benchmark modality images is obtained in other modality images best match positions by recurrence with the coordinate transformation model based on depth convolutional neural networks by the principle of similarity identification;The image of other mode is matched by method for registering with benchmark modality images;Multi-modal image after matching is regarded to multiple visual channel data of same mode, organ and lesion segmentation are carried out with this, segmentation is realized by full convolutional network.The beneficial effect is that can be reduced the metering of contrast medium introducing, achieve the purpose that the harm reduced contrast medium to human body, reduction medical treatment cost.It is targetedly identified and is divided for the CT image for introducing a small amount of contrast medium simultaneously, full-automation analysis interpretation tag image mitigates doctor's operating pressure to improve interpretation result accuracy.
Description
Technical field
The present invention relates to a kind of dividing method of liver CT images, point of especially a kind of multi-modal liver CT images
Segmentation method belongs to medical image processing technical field.
Background technique
Liver is the major organs of body metabolism, participates in the metabolism such as synthesis, decomposition, the excretion of many kinds of substance in vivo, when
When obstacle occurs for liver function, entire body all can be impacted.
The image-forming principle of CR scanning (Computed Tomography, CT) is from all angles X-ray
Radiation exposure human body, since Different Organs in human body and the density of tissue are different with thickness, so that X-ray passes through human body
There can be different degrees of decaying after different tissues, the grayscale perspective view of different tissues or organ can be obtained according to attenuation degree
Picture.
When lesion or suspected lesion occur for liver, inspection often is scanned to liver using CT, however CT is examined
It looks into, between liver organization, especially intralesional, external structure display has different degrees of limitation, this due to isodensity
Caused lack of resolution causes difficulty to clinical qualitative, quantitative Diagnosis, therefore, the CT scan in hepatic disease at present
When operation, people are accustomed to introducing the contrast medium such as allusion quotation kind acid or the meglumine iodipamide through hepatic excretion, keep the difference of its ambient density most
It possibly separates, institutional framework, focus characteristic is shown sufficiently with its striking contrast.
With the application of the imaging techniques such as CT, medical image processing and analysis have become current medical technology it is with fastest developing speed,
One of most significant field of achievement.However for if any allusion quotation allergy medical history person;Azotemia patient;There are asthma, kidney function energy barrier
Hinder, heart disease, lung, bronchus patient;Diabetic;Some special populations such as baby and old man introduce liver contrast medium,
Adverse reaction may be caused, less serious case can cause vomiting, is uncomfortable in chest etc., and discomforts, severe one cause shock even dead.And it does not introduce completely
Contrast medium will cause negative effect to the interpretation effect of imaging, it is difficult to the accurate judgement state of an illness again.And draw due to reducing contrast medium
Enter the CT imaging shot after amount, in a kind of liver contrast medium Digital Subtraction proposed by designer of the present invention
After angiographic method processing, the artificial read tablet of image department doctor is needed, manual dividing mark lesions position interprets CT image, low efficiency
Lower and judgment accuracy can also be fluctuated with operating time, the psychology of doctor state, and general Hepatic CT image division method
Not for the Hepatic CT imaging after a small amount of contrast medium of introducing, the judgement of machine knowledge figure may be influenced because of contrast medium, the present invention
Designer proposes the matched present invention side while proposing a kind of liver contrast medium digital subtraction angiography method
Case.
Summary of the invention
In order to overcome the shortcomings of the dividing method in the prior art without multi-modal liver CT images, the purpose of the present invention
It is to provide for a kind of dividing method of multi-modal CT images, which can cooperate matches with the present invention program
A kind of liver contrast medium digital subtraction angiography method carries out artificial intelligence interpretation, while comparing mass data library data, accurately
The position of lesion in image is marked, and doctor is assisted to judge coincident with severity degree of condition.This angiographic method can reduce contrast medium introducing
Metering, thus achieve the purpose that reduce contrast medium to the harm of human body, reduce medical treatment cost.It is a small amount of right for introducing simultaneously
CT image than agent targetedly identified and divided, with " multi-modal 3D autoregistration and based on deep learning
Calculation machine vision " method, full-automation analysis interpretation tag image, improves interpretation result accuracy to reach, mitigates doctor's work
Make the purpose of pressure.
In order to reach the purpose of the present invention, the technical solution adopted by the present invention to solve the technical problems is:
It is including following using being based on the matched spatial alternation algorithm of object High redundancy and full convolutional network image segmentation
Step:
Step 1: being selected as benchmark modality images for any one mode in multi-modality images, other mode are subject to registration
Image.A series of control points, the generally fixed array (Fig. 4 a) of distance interval are positioned in benchmark modality images;
Step 2: spatial alternation is carried out to the image of other mode.As Fig. 2 passes through phase using similarity regression model
Benchmark modality images are obtained by returning with the coordinate transformation model based on depth convolutional neural networks like the principle of degree identification
Best match position (Fig. 4 b) of the control point on image subject to registration;
Step 3: according to control point by elastic deformation, each pixel of benchmark modality images is obtained on image subject to registration
Corresponding position, by sampling obtain with the matched deformed image (Fig. 4 c) subject to registration of benchmark modality images, with reference map
Merge as being stacked on channel dimension;
Step 4: the multi-modal image after merging is regarded to multiple visual channel data of same mode, device is carried out with this
Official and lesion segmentation, segmentation are realized by full convolutional network.
Further, in step 1, select 20 × 20 × 20 control lattice array, i.e., the length and width of reference images,
Coordinate of 20 equally distributed positions as control point in each dimension is respectively selected on high direction.
Further, in step 2, the measuring similarity of local image where control point and control point return and use two
The binary channels convolutional network of input is realized.
Further, the characteristics of image on the periphery at some control point of reference images is extracted in one channel of convolutional network, another
The characteristics of image of matching image same position is extracted in channel, and the same full articulamentum is accessed in two channels after convolutional layer, realizes
Information merges.
Further, in step 3, method for registering realizes that Control point mesh is in any deformation using elastic deformation
Registration under the conditions of (non-affine transforms).
Further, in step 4, the data of the different radiography phases in the homogeneous inspection after registration by stacking side by side
The mode in channel is superimposed, and the form that more image datas become single image data is split.
Further, parted pattern used in step 4 is full convolutional network, is divided into two ranks of compression and decompression
Section, the intensive connection reinforcement between convolution loop network layer and two stage each level that network passes through middle part is to data sky
Between on association modeling.Model does not need to post-process, and the output of network model is final segmentation result.
Further, the full convolutional neural networks model in step 2 and step 4 is all using the training of method end to end.
Present invention has the main advantage that (1) control point+spatial alternation+elastic deformation registration method is suitable for 2D, 3D
Or the data of other dimensions, in addition to CT images can also be used for multi-modal 2D medical imaging;(2) it is first registrated and is divided again
It cuts, so that different information of the same object on different modalities, which is able to be divided, utilizes (the lesion in existing liver CT images
Semantic segmentation is usually that each mode individually carries out), be conducive to little in the pixel intensity value and surrounding tissue difference of lesion
In the case of accurate segmentation, also therefore, the requirement to the concentration of contrast medium is lower;(3) based on same reason, training segmentation
Full convolutional network only need the image for benchmark mode a segmentation mark is provided rather than more parts, reduce mark work
It measures;(4) pseudo-crystalline lattice of matching based on spatial alternation is end-to-end working method, can further be subtracted by analogue data training
Data needed for few training.Other than liver radiography, the present invention also can be applied to other using contrast agent and carry out repeatedly at
The inspection of picture, it is relatively common especially on internal organs, such as liver, stomach, pancreas etc., lung can also on certain tumor examinations
To adopt this method.
Detailed description of the invention
Fig. 1 is implementation whole process figure of the invention.
Fig. 2 is method for registering schematic diagram.
Fig. 3 is the neural network model of liver ontology and tumor focus segmentation.
Fig. 4 a- Fig. 4 c is that Ground control point matching and image carry out elastically-deformable schematic diagram, wherein Fig. 4 a represents reference map
Picture and control point;Fig. 4 b represents the corresponding position of image subject to registration and control point on it;Fig. 4 c represent after elastic deformation to
It is registrated image.
Below by drawings and examples, the invention will be further described.
In conjunction with Fig. 1, the more radiography issues of the liver of input are according to here including same patient the same as the unenhanced phase once checked
(claiming NC afterwards), artery enhance the CT images of phase (claiming AT afterwards), portal vein enhancing phase (claiming PV afterwards) this 3 radiography phases.The size of image
For H × 512 × 512, i.e., length and width are 512, height it is indefinite (whether between different patients or the not same period of same patient it
Between), but it is not less than 64 layers.The thickness in the direction H is indefinite, but should be consistent with the 3 radiography issues evidences once checked.Image
It is pre-processed first, carries out image smoothing filtering technique, press (NC, AT) afterwards, two pairs of sequences of (NC, PV) carry out registration calculating, will
In AT, PV Image registration to NC image.
In conjunction with Fig. 2, registration process first by the image (by taking NC as an example) of a certain mode as benchmark mode image Ub, with
Contrast image U (by taking AT or PV as an example) while input space measuring similarity network.Measurement network is according to being determined in advance Ub's
3D grid G finds respective coordinates θ of each node of G on U.By θ input space transformation model T, transformation parameter T is obtainedθ
(G).Each space pixel of Ub is navigated to by the position on U using elastic deformation method according to the transformation parameter at control point:
Wherein: p represents control point, and x is coordinate position of a certain pixel of benchmark image on x dimension, xpIt is control point p
Coordinate position on the x dimension of benchmark image, △ p are displacement of the p after spatial alternation, and c is specific non-linear function, T
(x) it is coordinate position after this pixel transform on x dimension.
Then the numerical value that this pixel is determined by bilinear interpolation finally obtains the transformed image V of U.Transformation front and back
Effect refers to Fig. 4 a- Fig. 4 c.
The output of space similarity regression model is (corresponding to return using the coordinate of grid G node as three values of reference origin
3D coordinate), model is realized using convolutional neural networks and is returned, and network passes through people by the training of mode end to end, training sample
Work mark converts to obtain to image progress random deformation.
In conjunction with Fig. 3, after being registrated work, by NC, the image of AT, PV are successively arranged side by side on channel dimension.Former image
It is all 1 channel, the data after Juxtaposition and Superimposition are 3 × H × 512 × 512.Data carry out figure by the full convolutional network of 3D after superposition
As semantic segmentation, the categorical measure of segmentation object determines as needed, says by taking background, liver ontology, 3 class of tumour as an example here
It is bright.The full convolutional network of segmentation is divided into compression (left side) and decompression (right side) two parts, is respectively divided into the processing of 4 grades.Compression unit
Dividing each grade includes down-sampled, 2 layers of convolution connection+activation primitive layer, and image data is every to pass through level-one, and size halves, channel
Several times increase, and it is later 48,96,192 that first order E1 output, which is 24 channels,.The decompression each grade in part includes connection, rises and adopt
Sample, level 2 volume product connection+activation primitive layer, image data is every to pass through level-one, and size doubles, and output channel number halves, D4~D1
Respectively 96,48,24,3.Be convolution loop network layer in intermediate M grade, for realizing model on the direction height H each number of plies
According to association.In addition, there is intensive connection in model, between the two-part each level in left and right to increase height before and after data
Density connection, it is therefore intended that improve the precision of segmentation.
Claims (10)
1. a kind of dividing method of multi-modal CT images, it is characterised in that become using based on the matched space of object High redundancy
Scaling method and full convolutional network image segmentation, include the following steps:
Step 1: selection benchmark modality images arrange a series of control points wherein;
Step 2: similarity regression model is used, by the principle of similarity identification, with the seat based on depth convolutional neural networks
Transformation model is marked, by returning the control point for obtaining benchmark modality images in other modality images best match positions;
Step 3: other modality images are matched by method for registering with benchmark modality images;
Step 4: using the multi-modal image after matching as multiple visual channel data of same mode, pass through full convolutional network
Carry out organ and lesion segmentation.
2. the dividing method of the multi-modal liver CT images of one kind according to claim 1, which is characterized in that the step
The specific arrangement method at control point in rapid one are as follows: selection 20 × 20 × 20 control lattice array, i.e., the length of benchmark modality images,
Coordinate of 20 equally distributed positions as control point in three dimensions is respectively selected on wide, high direction.
3. the dividing method of the multi-modal liver CT images of one kind according to claim 1, which is characterized in that the step
The identification of the measuring similarity of local image where control point is realized using the binary channels convolutional network of two inputs in rapid two.
4. the dividing method of the multi-modal liver CT images of one kind according to claim 1, which is characterized in that the step
The recurrence at control point is realized using the binary channels convolutional network of two inputs in rapid two.
5. the dividing method of the multi-modal liver CT images of one kind according to claim 3 or 4, which is characterized in that described
In binary channels convolutional network, the characteristics of image on the periphery at some control point in benchmark modality images, Ling Yitong are extracted in a channel
Extract corresponding characteristics of image in matched modality images in road.
6. the dividing method of the multi-modal liver CT images of one kind according to claim 1, which is characterized in that the step
Method for registering in rapid three realizes matching under the conditions of Control point mesh is in any deformation (non-affine transforms) using elastic deformation
It is quasi-.
7. the dividing method of the multi-modal liver CT images of one kind according to claim 1, which is characterized in that the step
The data of the different radiography phases in homogeneous inspection after being registrated in rapid four are superimposed by way of channel arranged side by side, by more image datas
The form for becoming single image data is split.
8. the dividing method of the multi-modal liver CT images of one kind according to claim 7, which is characterized in that the segmentation
Model is full convolutional network, is divided into two stages of compression and decompression, convolution loop network layer and two ranks of the network by middle part
Intensive connection reinforcement between each level of section models the association of data spatially.
9. the dividing method of the multi-modal liver CT images of one kind according to claim 7 or 8, which is characterized in that described
The output of parted pattern is final segmentation result.
10. the dividing method of the multi-modal liver CT images of one kind according to claim 1, which is characterized in that described
Full convolutional neural networks model in step 2 and step 4 is all made of method training end to end.
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