CN110226924A - A kind of wearable blood pressure monitoring device and method - Google Patents
A kind of wearable blood pressure monitoring device and method Download PDFInfo
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- CN110226924A CN110226924A CN201910425933.8A CN201910425933A CN110226924A CN 110226924 A CN110226924 A CN 110226924A CN 201910425933 A CN201910425933 A CN 201910425933A CN 110226924 A CN110226924 A CN 110226924A
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- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
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- A—HUMAN NECESSITIES
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- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/021—Measuring pressure in heart or blood vessels
- A61B5/02108—Measuring pressure in heart or blood vessels from analysis of pulse wave characteristics
- A61B5/02125—Measuring pressure in heart or blood vessels from analysis of pulse wave characteristics of pulse wave propagation time
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Abstract
The invention discloses a kind of wearable blood pressure monitoring devices, including Body Control Module and wearing module；Body Control Module includes diaphragm-type blood pressure sensing module, blood pressure computing module, data disaply moudle, wherein, phase of the diaphragm-type blood pressure sensing module based on reflected light at diaphragm with vascular wall relax contracting movement and the principle that changes, phase change information that the easypro contracting conversion of motion of vascular wall is reflected light is acquired into the blood vessel physiological activity signal for carrying blood pressure information；The invention also discloses a kind of monitoring of blood pressure methods, the blood vessel physiological activity signal captured is handled, the time difference between dicrotic wave wave crest and main wave wave crest is calculated as the blood reflux time, the direct relation model between blood reflux time and systolic pressure and diastolic pressure is established respectively, calculates pressure value；The present invention can monitor the blood pressure dynamic change in daily routines precisely in real time, solve the problems such as sensitivity existing in the prior art is low, accuracy is low.
Description
Technical field
The invention belongs to wearable technical field of medical equipment, more particularly, to a kind of wearable blood pressure monitoring device
And method.
Background technique
It is counted within 2012 according to the World Health Organization, there are about 17,500,000 people to suffer from cardiovascular disease in the whole world, and with economy
Development, rhythm of life are accelerated, this number is growing continuously at present.And blood pressure level and cardiovascular risk have direct pass
System, such as hypertension are the major reasons that auricular fibrillation occurs, therefore monitoring of blood pressure is for the diagnosis of early stage cardiovascular disease and pre-
It is anti-to be of great significance.
Traditional cuff type auscultation measuring device can bring stronger sense of discomfort in measuring phases to patient, be confined to the period
Property discontinuous measurement, can not reflect Diurnal blood pressure change situation, and then can not effectively be prevented sudden-onset cardiovascular disease.
Current blood pressure detector mostly be based on photoplethysmographic graphical method (PPG,
Photoplethysmography blood pressure detector), it acquires pulse wave for the absorption and reflection of light according to human body,
But it is this based on the method for PPG during measuring blood pressure vulnerable to electromagnetism, the colour of skin, ambient light, movement bring light
Etc. factors interference, can not continuously obtain the human pulse wave signal of high-fidelity, cause measurement sensitivity and poor accuracy it is strong
People's will, while not also being suitable in magnetic nuclear resonance environment.
Therefore, need to research and develop a kind of high sensitivity, the wearing for continuity monitoring of blood pressure that accuracy is strong, comfort is good
Device is worn, systolic pressure and diastolic pressure information can be obtained precisely in real time, provides weight for the early diagnosis and prevention of related disease
It will foundation.
Summary of the invention
In view of the drawbacks of the prior art, the purpose of the present invention is to provide a kind of wearable blood pressure monitoring device and method,
Aim to solve the problem that the low problem of existing blood pressure monitoring device sensitivity.
To achieve the above object, one aspect of the present invention provides a kind of blood pressure monitoring device, including Body Control Module；Its
In, Body Control Module is used to sensing diaphragm into the blood vessel physiology for carrying blood pressure information as a kind of sensing transducer part living
Dynamic signal calculates pressure value based on blood vessel physiological activity signal building blood pressure computation model, and real-time display comes out；Main body
Control module includes: diaphragm-type blood pressure sensing module, blood pressure computing module, data disaply moudle；Diaphragm-type blood pressure sensing module
Output end be connected with the input terminal of blood pressure computing module, the output end of blood pressure computing module and the input terminal of data disaply moudle
It is connected；Diaphragm-type blood pressure sensing module changes for the phase based on reflected light at pressure-sensitive diaphragm with the easypro contracting campaign of vascular wall
Principle, the phase change information that the easypro contracting conversion of motion of vascular wall is reflected light is acquired into blood vessel physiological activity signal；Blood
Pressure computing module is used to extract the blood reflux temporal information that can react arterial compliance in the blood vessel physiological activity signal,
The direct relation of the temporal information and systolic pressure SBP and diastolic pressure DBP are determined to obtain pressure value；The data disaply moudle
For the measurement result of real-time display blood pressure, play the role of real-time monitoring.
Preferably, diaphragm-type blood pressure sensing module includes light transmission unit, diaphragm-type blood pressure probe, light receiving unit, three
Port unit；Three port units include input port, Centronics port, output port；The output end of light transmission unit and three ports
The input port of unit is connected, and diaphragm-type blood pressure probe is connected with the Centronics port of three port units, the input of light receiving unit
End is connected with the output port of three port units；Light transmission unit is used to send the narrow-linewidth laser signal of C-band to diaphragm-type
On blood pressure probe；Diaphragm-type blood pressure is popped one's head in for carrying blood pressure information using diaphragm as a kind of sensing transducer part to capture
Blood vessel physiological activity signal, receives at diaphragm reflected light signal and as the medium of carrying blood vessel physiological activity, will be due to
Blood vessel physiological activity causes the changed optical signal of phase to be reflected on light receiving unit；Light receiving unit is used for optical signal
It is converted into electric signal, is convenient for phase extraction.The diaphragm-type blood pressure sensing module can greatly improve the sensitive of blood pressure measurement
Degree, while also having the function of electromagnetism interference, it can be adapted in magnetic nuclear resonance environment.
Preferably, diaphragm-type blood pressure probe includes transmission fiber and diaphragm type energy transducer, and the end of transmission fiber has one
A oblique 8 ° of inclination angle, can reduce the Fresnel reflection with air dielectric, that is to say, that the reflection of optical signal herein can neglect
Slightly disregard, transmission fiber and diaphragm type energy transducer spacing about hundreds of microns, centre form air dielectric chamber；Diaphragm type energy converter
Part can reflect the optical signal sended over via transmission fiber；Diaphragm type energy transducer is for believing blood vessel physiological activity
Number it is converted into the phase change information of reflected light；Transmission fiber is used for transmission the optical signal and the diaphragm of light transmission unit sending
The optical signal that formula energy transducer reflects back, it is preferable that transmission fiber can be single mode optical fiber.
Preferably, in diaphragm-type blood pressure probe, diaphragm type energy transducer is made of compound film sheet, and vascular wall relaxes contracting activity
It will lead to the diaphragm type energy transducer and generate periodic vibration, change so as to cause air chamber longitudinal length, so that institute
The light path for stating the light that light transmission unit sends over changes, and the phase information of reflected light at diaphragm is further caused to occur
Change.The diaphragm-type blood pressure, which is popped one's head in, can sense the movement of small vascular wall, obtain the high blood vessel physiological activity letter of signal-to-noise ratio
Number.
Preferably, diaphragm type energy transducer is by dimethyl silicone polymer (PDMS, polydimethylsiloxane)+silver
(Ag) compound film sheet is made.This compound film sheet has both the advantage of PDMS and Ag film, micromation, be easy to encapsulate be integrated into it is wearable
Device, Young's modulus is small, good biocompatibility, it is corrosion-resistant, can be closely adhered to and eliminate the air gap in skin surface, have
Very high sensitivity.
Preferably, in three port unit, light can only prolong a direction and carry out one way propagation, and light is defeated from input port
Enter, is then exported from Centronics port；Light is inputted from Centronics port, then is exported from output port.Preferably, three port units can be
Circulator.In three port units, light can only unidirectional delivery, and loss is smaller when transmitting, and guarantees the validity of optical signal.
Preferably, blood pressure computing module includes phase-demodulation unit, denoising unit, Feature point recognition unit, blood pressure calculating
Unit；The output end of phase-demodulation unit is connected with the input terminal of denoising unit, denoises the output end and Feature point recognition of unit
The input terminal of unit is connected, and the output end of Feature point recognition unit is connected with the blood pressure calculation unit；Phase-demodulation unit pair
The phase information of the reflected light carries out demodulation to restore blood vessel physiological activity signal；Preferably, coherent phase can be used
Demodulating algorithm carries out phase demodulating；Unit is denoised to be used to carry out denoising to the blood vessel physiological activity signal；Preferably, it goes
Unit of making an uproar can be denoised using multinomial algorithm and wavelet algorithm, wherein multinomial algorithm is made an uproar to eliminate baseline drift
Sound, wavelet algorithm is to eliminate system noise；Feature point recognition unit is used to obtain the master in the blood vessel physiological activity signal
Temporal information corresponding to wave wave crest and dicrotic wave wave crest, using the time difference of the two as the blood reflux time；Blood pressure calculates single
Between computation model and blood reflux time and diastolic pressure DBP of the member for constructing blood reflux time and systolic pressure SBP
Computation model calculates pressure value.The blood pressure computing module can guarantee accurately to monitor blood pressure information.
Preferably, wearable blood pressure monitoring device further includes wearing module, wearing module and the Body Control Module
Both ends are respectively connected with, and form an endless means；Wearing module is for blood pressure monitoring device to be fixed at monitoring point；Dress mould
Block includes snap fastener and flexible wristband；The both ends tail portion of flexible wristband is connect with snap fastener, constitutes length-adjustable object wearing device；
Flexible wristband ontology is made of high resiliency skin compatible material；Snap fastener includes sub-buckle and female thread, and sub-buckle can be separated with female thread, can also
To be anchored in female thread, for adjusting the length of flexible wristband.The design of this wearing module can guarantee that diaphragm-type blood pressure is visited
Head is closely comfortably fitted at monitoring point, is created condition for the continuous monitoring of blood pressure.
The second aspect of the present invention is to provide for a kind of monitoring of blood pressure method, comprising:
S11, blood vessel physiological activity signal is obtained；
S12, blood vessel physiological activity signal is handled, obtains the peak time of the peak time point and dicrotic wave of main wave
Point, and the time difference between dicrotic wave wave crest and main wave wave crest is calculated as the blood reflux time；
S13, according to the relationship between the blood reflux time and blood pressure, construct blood pressure computation model；
S14, current pressure value is calculated based on blood reflux time and blood pressure computation model.
Preferably, blood pressure computation model are as follows:
Wherein, BRT is the blood reflux time, and SBP is systolic pressure, and DBP is diastolic pressure, Ya、Yb、YcFor BRT-SBP model
Fitting coefficient, Ka、Kb、KcFor the fitting coefficient of BRT-DBP model；
In the blood pressure computation model, blood reflux time BRT is respectively between systolic pressure SBP and diastolic pressure DBP
In non-linear relation；
The fitting coefficient Y of the BRT-SBP modela、Yb、YcBy being carried out to blood reflux time and systolic pressure standard value
Nonlinear regression analysis obtains optimal solution to determine；The fitting coefficient K of the BRT-DBP modela、Kb、KcBy to blood reflux
Time carries out nonlinear regression analysis acquisition optimal solution with diastolic pressure standard value to determine；The fitting coefficient can be used to reflect
The physiological status of blood vessel.When constructing the blood pressure computation model, it is contemplated that density of blood, artery radius, artery thickness, blood vessel hold
The influence of the blood vessels physiologic factor such as accumulated amount, vessel wall elasticity determines resulting blood reflux time and systolic pressure SBP respectively and relaxes
The direct relation for opening pressure DBP, so that result is more accurate.
Contemplated above technical scheme through the invention can achieve the following beneficial effects compared with prior art:
1, the present invention captures blood pressure physiological activity signal using diaphragm-type blood pressure sensing module, is based primarily upon inside modules
Diaphragm-type blood pressure probe sense the easypro contracting campaign of vascular wall, the diaphragm type energy transducer in the probe is compound by PDMS+Ag
Diaphragm is made, and has both the advantage of PDMS and Ag film, and Young's modulus is small, very sensitive to small vibration, can capture faint
Vascular wall relax contracting movement, to substantially increase the sensitivity of blood pressure measurement.Meanwhile the probe optical signal transmission fiber,
Therefore have the function of natural electromagnetism interference, it can be adapted in magnetic nuclear resonance environment.
2, it is based on collected blood vessel physiological activity signal, invention defines a kind of sides for calculating the blood reflux time
Method, when constructing blood pressure computation model, it is contemplated that density of blood, ductus arteriosus wall compliance thickness, ductus arteriosus wall radius and blood
The influence of the blood vessels physiologic factors such as tube capacity product finally respectively obtains blood reflux time and systolic pressure, blood reflux time and relaxes
The direct nonlinear model between pressure is opened, resulting maximum absolute error is measured no more than 4mmHg, the essence of measurement can be greatly improved
Exactness.
3, the present invention provides a kind of wearable blood pressure monitoring devices, dress module and are mutually tied using snap fastener with flexible wristband
The mode of conjunction realizes the design of length-adjustable wearable device, guarantees that device is fitted tightly on human skin, measuring phases
Sense of discomfort will not be introduced, the continuous BP measurement of noninvasive, sleeveless, high degree of comfort may be implemented, solves traditional cuff type auscultation
The problems such as measuring device can not continuously monitor pressure value, comfort level is lower.
4, blood pressure monitoring device provided by the present invention can be closely fitted on human body wrist, will not be with human body
It moves and generates relative displacement, blood pressure can be monitored in daily life, be not limited to stationary state, the company that can be used in motion process
Continuous blood pressure monitoring.
5, the material of device of the present invention is easily obtained, and whole device is easy to accomplish, cost is relatively low, reliable for operation.
Detailed description of the invention
Fig. 1 is Body Control Module provided by the invention and wearing module connection diagram；
Fig. 2 is the structure chart of blood pressure monitoring device provided by the invention；
Fig. 3 is the structural schematic diagram of diaphragm-type blood pressure sensing module provided by the invention；
Fig. 4 is the structural schematic diagram of diaphragm-type blood pressure provided by the invention probe；
Fig. 5 is the schematic diagram for the blood reflux time BRT that the present invention defines；
Fig. 6 is the fitting schematic diagram of blood pressure computation model in the embodiment of the present invention, and figure (a) is systolic pressure fitting result figure,
Scheming (b) is diastolic pressure fitting result figure.
Specific embodiment
In order to make the objectives, technical solutions, and advantages of the present invention clearer, with reference to the accompanying drawings and embodiments, right
The present invention is further elaborated.It should be appreciated that the specific embodiments described herein are merely illustrative of the present invention, and
It is not used in the restriction present invention.
The present invention relates to a kind of wearable blood pressure monitoring device and methods, wherein the blood pressure monitoring device includes main body control
Molding block and wearing module.Fig. 1 is the Body Control Module and wearing module of wearable blood pressure monitoring device provided by the invention
Connection schematic diagram.As shown, Body Control Module 1 is embedded among wearing module 2, wherein Body Control Module 1 is used for
Diaphragm is sensed to the blood vessel physiological activity signal for carrying blood pressure information as a kind of sensing transducer part, is based on the blood vessel
Physiological activity signal constructs blood pressure computation model and calculates pressure value, and real-time display comes out；Module 2 is dressed to be used for monitoring of blood pressure
Device is fixed at monitoring point, and wrist belt length is adjustable to adapt to Different Individual, and guarantees the comfort level of measuring phases.
Fig. 2 is the structural schematic diagram of wearable blood pressure monitoring device provided by the invention, and Body Control Module 1 includes diaphragm
Type blood pressure sensing module 3, blood pressure computing module 4, data disaply moudle 5；Wherein, the output end of diaphragm-type blood pressure sensing module 3
It is connected with the input terminal of blood pressure computing module 4, the output end of blood pressure computing module 4 is connected with the input terminal of data disaply moudle 5；
The original that diaphragm-type blood pressure sensing module 3 changes for the phase based on reflected light at pressure-sensitive diaphragm with the movement of the easypro contracting of vascular wall
Reason, the conversion of motion to contract that vascular wall is relaxed are the phase change information of reflected light to acquire blood vessel physiological activity signal, it is main
Including light transmission unit 31, diaphragm-type blood pressure probe 32, light receiving unit 33；Blood pressure computing module 4 is for extracting the blood vessel
The blood reflux temporal information that arterial compliance can be reacted in physiological activity signal determines the temporal information respectively and shrinks
The direct relation of SBP and diastolic pressure DBP is pressed to obtain pressure value；Data disaply moudle 5 is used for the measurement knot of real-time display blood pressure
Fruit plays the role of real-time monitoring.Dressing module includes flexible wristband 6, snap fastener 7；6 ontology of flexible wristband is by high resiliency pro-skin
Material is made, and snap fastener 7 includes sub-buckle and female thread, and the both ends end for being fitted tightly over flexible wristband respectively constitutes adjustable in length
Object wearing device.
Blood vessel physiological activity signal is as a kind of periodical minute-pressure force signal, and detection difficulty is larger, and vulnerable to ambient enviroment
Factor interference, diaphragm-type blood pressure sensing module provided by the invention are carried using diaphragm as a kind of sensing transducer part to sense
The blood vessel physiological activity signal of blood pressure information, the phase based on reflected light at pressure-sensitive diaphragm change with the easypro contracting campaign of vascular wall
Principle, the phase change information that the easypro contracting conversion of motion of vascular wall is reflected light is acquired into blood vessel physiological activity signal, greatly
The sensitivity of blood vessel physiological activity signal detection is improved greatly.
Fig. 3 is the structural schematic diagram of diaphragm-type blood pressure sensing module 3 provided by the invention, including transmission unit 31, diaphragm
Type blood pressure probe 32, light receiving unit 33, three port units 34；Wherein, three port units include input port 341, intermediate ends
Mouth 342 and output port 343；The output end of light transmission unit 31 is connected with the input port 341 of three port units 34, diaphragm-type
Blood pressure probe 32 is connected with the Centronics port 342 of three port units 34, the input terminal of light receiving unit 33 and three port units 34
Output port 343 be connected；Light transmission unit 31 is used to send the narrow-linewidth laser signal of C-band, which passes through three ends
The input port 341 of mouth unit 34 reaches the Centronics port 342 of three port units 34, finally reaches diaphragm-type blood pressure probe 32
On；Diaphragm-type blood pressure probe 32 carries the blood vessel life of blood pressure information for capturing diaphragm as a kind of sensing transducer part
Active signal is managed, receives reflected light signal at the diaphragm and as the medium of carrying blood vessel physiological activity, it will be due to blood
Pipe physiological activity causes the changed optical signal of phase to be reflected on light receiving unit 33；The changed reflected light warp of phase
By the output port 343 of 342 to three port unit 34 of Centronics port of three port units 34, light receiving unit 33 is finally reached；
Light receiving unit 33 converts optical signal into electric signal, it is preferable that light receiving unit 33 can be using balance photodetector BPD
Electric signal is converted optical signal into, phase extraction is convenient for.In three port units 34 light can only one way propagation, optical signal is from defeated
Inbound port 341 inputs, then can only export from Centronics port 342, and optical signal is inputted from Centronics port 342, then can only be from output end
Mouth 343 exports, it is preferable that three port units can be circulator.Wherein, diaphragm-type blood pressure probe 32 includes transmission fiber 321
With diaphragm type energy transducer 322, it is illustrated in figure 4 the structural schematic diagram of diaphragm-type blood pressure probe provided by the invention, transmits light
There is oblique 8 ° of inclination angle in the end of fibre 321, can reduce the Fresnel reflection with air dielectric, that is to say, that optical signal is at this
In reflection can be ignored, transmission fiber 321 and 322 spacing of diaphragm type energy transducer about hundreds of microns, centre form empty
Gas medium chamber；The optical signal that diaphragm type energy transducer 322 can send over transmission fiber 321 reflects；Diaphragm type transducing
Device 322 is bonded with skin surface, detects blood vessel physiological activity signal.Vascular wall carries out contracting movement of relaxing, positioned at the film of test point
Chip energy transducer 322 carries out periodic vibration with the easypro contracting of vascular wall, the light for causing light transmission unit 31 to send over
Light path changes, and changes so as to cause the phase of reflected light signal；Transmission fiber 321 is used for transmission light transmission unit 31
The optical signal that the optical signal and diaphragm type energy transducer 322 of sending reflect back.Further, diaphragm type energy transducer 322 by
Compound film sheet is made, it is preferable that diaphragm type energy transducer 322 is made of PDMS+Ag compound film sheet, as shown in figure 4,3221 be film
The PDMS film of chip energy transducer, the good biocompatibility of about 25um, PDMS, non-toxic to humans, Young's modulus is small, small
Vascular wall contracting activity of relaxing can also cause its vibration, with skin attachement almost without gap, the soft high resiliency of matter is sticked very easypro
Suitable, chemical inertness, anti-sweat is moisture-proof, but PDMS is transparent, so in order to enhance reflected light signal intensity at diaphragm, using true
The mode of sky vapor deposition has plated one layer of Ag film, and 3222 be Ag film, about 75nm.This compound film sheet has both the advantage of PDMS and Ag film,
Micromation, is easy to encapsulate and is integrated into wearable device, Young's modulus is small, good biocompatibility, it is corrosion-resistant, can be closely adhered to
The air gap is eliminated in skin surface, there is very high sensitivity.Therefore diaphragm-type blood pressure probe can sense small vascular wall
Movement, high sensitivity can obtain the high blood vessel physiological activity signal of signal-to-noise ratio.
Further, blood pressure computing module 4 includes phase-demodulation unit, denoising unit, Feature point recognition unit, sphygmomanometer
Calculate unit.The output end of phase-demodulation unit is connected with the input terminal of denoising unit, and the output end and characteristic point for denoising unit are known
The input terminal of other unit is connected, and the output end of Feature point recognition unit is connected with blood pressure calculation unit.Phase-demodulation unit is to adopting
The phase information of the reflected light collected carries out demodulation to restore blood vessel physiological activity signal, it is preferable that can use coherent phase
Position demodulating algorithm carries out phase demodulating.It denoises unit to be used to carry out denoising to blood vessel physiological activity signal, it is preferable that can be with
It is denoised using multinomial algorithm and wavelet algorithm, wherein multinomial algorithm is to eliminate baseline drift noise, wavelet algorithm
To eliminate system noise.Feature point recognition unit is used to obtain main wave wave crest and the dicrotic pulse in the blood vessel physiological activity signal
Temporal information corresponding to wave wave crest, using the time difference of the two as the blood reflux time；
The blood reflux time can represent arterial compliance to a certain extent and then reflect blood pressure level, arterial compliance reflection
The buffer capacity of vascular wall, it determines the transmission speed of pulse wave, and arterial compliance decline can weaken artery to blood flow
Buffer function cause blood pressure to increase, within the scope of certain time, the transmission speed of blood reflux time and pulse wave is in inverse ratio.
Blood pressure calculation unit is used to construct computation model and blood reflux time and the diastole of blood reflux time and systolic pressure SBP
The computation model between DBP is pressed to calculate pressure value.Data display unit 5 is used for the pressure value that real-time display is calculated.
By taking monitoring point is at the radial pulse of human body as an example, it is based on the wearable blood pressure monitoring device, the present invention mentions
Supply a kind of monitoring of blood pressure method the following steps are included:
Blood pressure monitoring device of the present invention is worn at wrist by step 1, gauger, adjusts the length of wrist strap, is protected
The diaphragm-type blood pressure probe of card device is tightly attached at human body radial pulse；
The reflective phase of blood vessel physiological activity signal at step 2, acquisition response measurement person's radial pulse changes letter
Breath；
Reflective phase change information is reverted to blood vessel physiological activity signal using coherent phase demodulating algorithm by step 3,
After being denoised, obtain the blood vessel physiological activity signal waveform of high-fidelity, calculate main wave wave crest between dicrotic pulse wave crest when
Between difference be used as the blood reflux time, current pressure value is then calculated according to blood pressure computation model；
Step 4, every 10s updates and display of blood pressure value, realizes the continuous monitoring of blood pressure；
Specifically, the construction method of blood pressure computation model specifically includes following steps in above-mentioned steps 3:
S31,80 volunteers are chosen, selected volunteer includes child, youth, middle age and old man；
S32, blood pressure monitoring device of the present invention is worn at the wrist of volunteer, adjusts the length of wrist strap, and
And guarantee that the diaphragm-type blood pressure probe of device is tightly attached at pulse；
S33, the blood vessel physiological activity signal that volunteer is acquired by the blood pressure monitoring device, each volunteer can acquire
Repeatedly, multiple groups blood vessel physiological activity signal is obtained.Typical blood vessel physiological activity signal reflects blood vessel in a cardiac cycle
The easypro contracting situation of wall, waveform are made of main wave and dicrotic wave, and when left ventricular contraction, a large amount of blood enter aorta, aorta
Therefore passive expansion forms main wave, and dicrotic wave is then in ventricular diastole, and the moment of aortic valve closing, blood is in aorta
Caused by backflowing to ventricle direction from peripheral artery, thus by blood reflux timing definition be main wave wave crest A to dicrotic pulse wave crest B when
Prolong, as shown in Figure 5.It the blood reflux time that volunteer is calculated according to resulting blood vessel physiological activity signal, uses at the same time
Using the standard systolic pressure and standard diastolic pressure of Omron commercialization blood pressure monitor measurement volunteer, 100 groups of blood refluxs are obtained
Time and corresponding systolic pressure standard value and 100 groups of blood reflux times and corresponding diastolic pressure standard value；
S34, blood pressure computation model is determined, within the scope of certain time, blood reflux time (BRT, Blood Return
Time it) is inversely proportional with pulse wave velocity (PWV, Pulse Wave Velocity), ductus arteriosus wall compliance, which reduces, increases PWV,
The blood reflux time reduces, while arterial compliance decline can weaken artery and cause blood pressure to increase the buffer function of blood flow, because
This, the blood reflux time can represent arterial compliance to a certain extent and then reflect blood pressure level.In view of density of blood, artery
The influence of the blood vessels physiologic factors such as radius, artery thickness, capacity of blood vessel amount, vessel wall elasticity derives blood reflux time and blood
Relation equation between pressure is as follows:
Wherein, BRT is the blood reflux time, and SBP is systolic pressure, and DBP is diastolic pressure, Ya、Yb、YcFor BRT-SBP model
Fitting coefficient, Ka、Kb、KcFor the fitting coefficient of BRT-DBP model.These fitting coefficients can be used to reflect the physiology shape of blood vessel
State.
Specifically, the relation equation derivation process of blood reflux time and blood pressure is as follows:
With according to Moens-Korteweg equation, PWV can use artery Young's modulus Ein, ductus arteriosus wall thickness h, artery radius
D, density of blood ρ is calculated:
Artery Young's modulus EinIt may be expressed as:
Ein=E0eα*MBP (4)
E herein0Indicate vascular wall Young's modulus when pressure value is 0, α is vessel properties parameter, and MBP is Mean Arterial
Pressure, wherein MBP and systolic pressure SBP and diastolic pressure DBP have following relationship:
On the other hand, according to Bramwell-Hill equation, pulse velocity of wave can be indicated are as follows:
Wherein V is intra-arterial blood volume, and dV indicates the variable quantity of intra-arterial blood volume, and dP is the blood between SBP and DBP
Pressure difference, unit mmHg.In addition, dP can be indicated are as follows:
DP=SBP-DBP (7)
It is inversely proportional between pulse wave velocity PWV and blood reflux time BRT, relationship is as follows:
Wherein, L is distance from peripheral artery to ventricle that flow back from of blood, is derived according to relational expression (3)-(8), can be with
The relationship of SBP, DBP and BRT are obtained respectively as formula (1) and formula (2) are shown.
S35, according to 100 groups of blood reflux times systolic pressure standard value corresponding with its obtained by step S13, and
100 groups of blood reflux times diastolic pressure standard value corresponding with its, carries out nonlinear regression analysis respectively, obtain formula (1) and
It the optimal solution of fitting coefficient and is stored in formula (2), to obtain blood reflux time and systolic pressure and blood reflux
Determination relationship between time and diastolic pressure, i.e. blood pressure computation model.
It is illustrated in figure 6 the fitting result schematic diagram of blood pressure computation model, wherein figure (a) is the fitting result of systolic pressure
Figure, reflects the relationship between systolic pressure and BRT；Scheme the fitting result figure that (b) is diastolic pressure, reflect diastolic pressure and BRT it
Between relationship.It can be seen from the figure that BRT is smaller, systolic pressure and diastolic pressure are bigger, this represents artery with theoretically BRT reduction
Compliance decline is consistent to the conclusion for increasing blood pressure.
The sphygmomanometer precision certification generally acknowledged in clinical medical in the world mostly uses Used In The Regulation of Medical Device In Usa to detect association
(AAMI) standard is compared with standard-sphygmomanometer reference value, if mean error is no more than 5mmHg and standard deviation is no more than
8mmHg, then it is assumed that the sphygmomanometer precision meets international standard.To the measurement result of blood pressure monitoring device provided by the present invention into
Row accuracy calculate maximum absolute error be no more than 4mmHg, meet Used In The Regulation of Medical Device In Usa detection association (AAMI) standard.
It should be noted last that the above specific embodiment is only used to illustrate the technical scheme of the present invention and not to limit it,
Although being described the invention in detail referring to preferred embodiment, as it will be easily appreciated by one skilled in the art that the above is only
For presently preferred embodiments of the present invention, it is not intended to limit the invention, it is done within the spirit and principles of the present invention
Any modifications, equivalent replacements, and improvements etc., should all be included in the protection scope of the present invention.
Claims (10)
1. a kind of wearable blood pressure monitoring device, which is characterized in that including Body Control Module；
The Body Control Module is used to diaphragm sensing the blood vessel for carrying blood pressure information as a kind of sensing transducer part
Physiological activity signal calculates pressure value based on blood vessel physiological activity signal building blood pressure computation model, and real-time display goes out
Come；
The Body Control Module includes: diaphragm-type blood pressure sensing module, blood pressure computing module, data disaply moudle；
The output end of the diaphragm-type blood pressure sensing module is connected with the input terminal of the blood pressure computing module, and the blood pressure calculates
The output end of module is connected with the input terminal of the data disaply moudle；
The diaphragm-type blood pressure sensing module for the phase based on reflected light at pressure-sensitive diaphragm with the easypro contracting campaign of vascular wall and
The principle of variation believes the phase change information that the easypro contracting conversion of motion of vascular wall is reflected light to acquire blood vessel physiological activity
Number；
The blood pressure computing module is used to extract the blood that can react arterial compliance in the blood vessel physiological activity signal and returns
Temporal information is flowed, determines the direct relation of the temporal information and systolic pressure SBP and diastolic pressure DBP to obtain pressure value；
The data disaply moudle is used for the measurement result of real-time display blood pressure, plays the role of real-time monitoring.
2. wearable blood pressure monitoring device according to claim 1, which is characterized in that the diaphragm-type blood pressure sensing module
Including light transmission unit, diaphragm-type blood pressure probe, light receiving unit, three port units；
Three port unit includes input port, Centronics port, output port；The output end of the smooth transmission unit with it is described
The input port of three port units is connected, and the diaphragm-type blood pressure probe is connected with the Centronics port of three port unit, institute
The input terminal for stating light receiving unit is connected with the output port of three port unit；
The narrow-linewidth laser signal that the smooth transmission unit is used to send C-band is popped one's head in the diaphragm-type blood pressure；
The diaphragm-type blood pressure probe is for capturing the blood for carrying blood pressure information as a kind of sensing transducer part for diaphragm
Pipe physiological activity signal, receives reflected light signal at the diaphragm and as the medium for carrying the blood vessel physiological activity,
The changed optical signal of phase will be caused to be reflected on light receiving unit due to blood vessel physiological activity；
The light receiving unit is convenient for phase extraction for converting optical signal into electric signal.
3. wearable blood pressure monitoring device as claimed in claim 2, which is characterized in that the diaphragm-type blood pressure probe includes passing
Fine and diaphragm type energy transducer is lost, there are oblique 8 ° of inclination angle, the transmission fiber and diaphragm in the end of the transmission fiber
Formula energy transducer spacing about hundreds of microns, centre form air dielectric chamber；The diaphragm type energy transducer can be to via the biography
The fine optical signal sended over is lost to be reflected；
The diaphragm type energy transducer is used to convert blood vessel physiological activity signal to the phase change information of reflected light；
The transmission fiber is used for transmission the optical signal of light transmission unit sending and the diaphragm type energy transducer reflects back
Optical signal.
4. wearable blood pressure monitoring device as claimed in claim 3, which is characterized in that in diaphragm-type blood pressure probe,
The diaphragm type energy transducer is made of compound film sheet, and the easypro contracting activity of vascular wall will lead to the diaphragm type energy transducer and generate week
The vibration of phase property, changes so as to cause air chamber longitudinal length, so that the light path for the light that the smooth transmission unit sends over
It changes, the phase information of reflected light at diaphragm is further caused to change.
5. wearable blood pressure monitoring device as described in claim 3 or 4, which is characterized in that the diaphragm type energy transducer by
Dimethyl silicone polymer (PDMS)+silver (Ag) compound film sheet is made.
6. wearable blood pressure monitoring device as claimed in claim 2, which is characterized in that in three port unit, light is only
A direction can be prolonged and carry out one way propagation, light is inputted from input port, then is exported from Centronics port；Light is inputted from Centronics port,
Then exported from output port.
7. wearable blood pressure monitoring device as described in claim 1, it is characterised in that the blood pressure computing module includes phase
Demodulating unit, denoising unit, Feature point recognition unit, blood pressure calculation unit；
The output end of the phase-demodulation unit with it is described denoising unit input terminal be connected, it is described denoising unit output end and
The input terminal of the Feature point recognition unit is connected, the output end of the Feature point recognition unit and the blood pressure calculation unit phase
Even；
The phase-demodulation unit carries out demodulation to the phase information of the reflected light to restore blood vessel physiological activity signal；
The denoising unit is used to carry out denoising to the blood vessel physiological activity signal；
The Feature point recognition unit is used to obtain main wave wave crest and the dicrotic wave wave crest institute in the blood vessel physiological activity signal
Corresponding temporal information, using the time difference of the two as the blood reflux time；
When the blood pressure calculation unit is used to construct the blood reflux time computation model and blood reflux with systolic pressure SBP
Between computation model between diastolic pressure DBP calculate pressure value.
8. wearable blood pressure monitoring device as described in claim 1, which is characterized in that the wearable blood pressure monitoring device is also
Including dressing module, the wearing module and the both ends of the Body Control Module are respectively connected with, and form an endless means；Institute
Wearing module is stated for the wearable blood pressure monitoring device to be fixed at monitoring point；The wearing module include snap fastener and
Flexible wristband；
The both ends tail portion of the flexible wristband is connect with snap fastener, constitutes length-adjustable object wearing device；
The flexible wristband ontology is made of high resiliency skin compatible material；
The snap fastener includes sub-buckle and female thread, and the sub-buckle can be separated with the female thread, may also snap into place to the female thread and works as
In, for adjusting the length of the flexible wristband.
9. a kind of a kind of monitoring of blood pressure method based on the wearable blood pressure monitoring device, which is characterized in that including；
S11, blood vessel physiological activity signal is obtained；
S12, the blood vessel physiological activity signal is handled, obtains the peak time of the peak time point and dicrotic wave of main wave
Point, and the time difference between dicrotic wave wave crest and main wave wave crest is calculated as the blood reflux time；
S13, according to the relationship between the blood reflux time and blood pressure, construct blood pressure computation model；
S14, current pressure value is calculated based on the blood reflux time and the blood pressure computation model.
10. monitoring of blood pressure method as claimed in claim 8, which is characterized in that the blood pressure computation model are as follows:
Wherein, BRT is the blood reflux time, and SBP is systolic pressure, and DBP is diastolic pressure, Ya、Yb、YcFor the fitting of BRT-SBP model
Coefficient, Ka、Kb、KcFor the fitting coefficient of BRT-DBP model；
In the blood pressure computation model, blood reflux time BRT is respectively in non-between systolic pressure SBP and diastolic pressure DBP
Linear relationship；
The fitting coefficient Y of the BRT-SBP modela、Yb、YcIt is non-thread by being carried out to the blood reflux time with systolic pressure standard value
Property regression analysis obtain optimal solution and determine；The fitting coefficient K of the BRT-DBP modela、Kb、KcBy to the blood reflux time
Nonlinear regression analysis acquisition optimal solution is carried out with diastolic pressure standard value to determine；The fitting coefficient can be used to reflect blood vessel
Physiological status.
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