CN110225740A - Oral care composition for the delivering of lasting peroxide - Google Patents

Oral care composition for the delivering of lasting peroxide Download PDF

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Publication number
CN110225740A
CN110225740A CN201880006592.4A CN201880006592A CN110225740A CN 110225740 A CN110225740 A CN 110225740A CN 201880006592 A CN201880006592 A CN 201880006592A CN 110225740 A CN110225740 A CN 110225740A
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Prior art keywords
whitening compositions
dental whitening
dental
copolymer
compositions according
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Chinese (zh)
Inventor
董蓉
许国锋
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Colgate Palmolive Co
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Colgate Palmolive Co
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
    • A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
    • A61K8/8158—Homopolymers or copolymers of amides or imides, e.g. (meth) acrylamide; Compositions of derivatives of such polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/0216—Solid or semisolid forms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/22—Peroxides; Oxygen; Ozone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
    • A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
    • A61K8/8147—Homopolymers or copolymers of acids; Metal or ammonium salts thereof, e.g. crotonic acid, (meth)acrylic acid; Compositions of derivatives of such polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
    • A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
    • A61K8/8152—Homopolymers or copolymers of esters, e.g. (meth)acrylic acid esters; Compositions of derivatives of such polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
    • A61K8/817—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen; Compositions or derivatives of such polymers, e.g. vinylimidazol, vinylcaprolactame, allylamines (Polyquaternium 6)
    • A61K8/8182—Copolymers of vinyl-pyrrolidones. Compositions of derivatives of such polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/90—Block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A61Q11/02—Preparations for deodorising, bleaching or disinfecting dentures

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Birds (AREA)
  • Emergency Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Cosmetics (AREA)

Abstract

A kind of dental whitening compositions are provided, it includes: hydrophobic copolymer, hydrophilic brighteners and polar solvent.

Description

Oral care composition for the delivering of lasting peroxide
Background technique
Many substances can colour tooth or reduce the whiteness of tooth.Specifically, food, the tobacco product of people intake It is easy to make its tooth staining with fluid.These products or substance are easy to be accumulated on the adamantine layer of tooth and the shape on tooth At mycoderm.The dental whitening compositions containing active brightener for tooth can be used to reduce coloring and whitening teeth.Due to peroxide The volatility and reactivity of compound, therefore certain brightening agents such as peroxide may bring preparation difficult.
The extended delivery for providing active brightener for tooth will be advantageous.However, for applying dental whitening group to tooth The polymeric delivery systems of conjunction object are usually not proved durable enough to be maintained on tooth for a long time.Other reasons have, tooth Physical abrasion occurs because brushing teeth and chewing for tooth, and further, since feeds and drink water and be exposed to extensive temperature and pH water It is flat.Therefore, under normal circumstances, most polymers will not stay on tooth for a long time.In addition, such system, which may cause, to be made The uncomfortable or offending mouthfeel of user.Further, it is desirable to material (including the polymeric delivery systems of dental whitening compositions itself In polymer) be not easy to absorb spot or otherwise make tooth discoloration.
Summary of the invention
Present disclose provides a kind of dental whitening compositions, it includes: hydrophobic copolymer；Hydrophilic brighteners；The pole and Property solvent.
In an embodiment of disclosed dental whitening compositions, hydrophobic copolymer is film forming hydrophobicity copolymerization Object.
In an embodiment of disclosed dental whitening compositions, film forming hydrophobic copolymer includes to be configured to glue It is attached to the functional group of dental surface.
In an embodiment of disclosed dental whitening compositions, hydrophobic copolymer includes acrylate.
In an embodiment of any disclosed dental whitening compositions, hydrophobic copolymer includes acrylic acid Ester/octylacrylamido, VA/ butyl maleate/isobornyl acrylate copolymer, acrylate/tert-butyl propylene Amide copolymer, polyvinylpyrrolidone//vinyl acetate copolymers, melissyl PVP copolymer, acrylate/methyl-prop At least one of olefin(e) acid dimethylamino ethyl ester copolymer or their mixture.
In an embodiment of any disclosed dental whitening compositions, hydrophobic copolymer includes 2- acrylic acid 2- methyl -, 2- methyl-prop base ester, the polymer with 2- acrylic acid and N- (1,1,3,3- tetramethyl butyl) -2- acrylamide.
In an embodiment of any disclosed dental whitening compositions, hydrophobic copolymer is to be greater than about 0 weight The amount for measuring % to about 30 weight % exists.
In an embodiment of any disclosed dental whitening compositions, hydrophilic brighteners include peroxidating Object.
In an embodiment of any disclosed dental whitening compositions, brightening agent includes hydrogen peroxide.
In an embodiment of any disclosed dental whitening compositions, hydrophobic copolymer is to be greater than about 0 weight The amount for measuring % to about 12 weight % exists.
In an embodiment of any disclosed dental whitening compositions, polar solvent includes ethyl alcohol.
In an embodiment of any disclosed dental whitening compositions, composition is the acceptable combination in oral cavity Object.
In an embodiment of any disclosed dental whitening compositions, composition is film-forming composition.
In an embodiment of any disclosed dental whitening compositions, composition is in liquid form.
In an embodiment of any disclosed dental whitening compositions, composition is in gel form.
In an embodiment of any disclosed dental whitening compositions, composition does not include nonpolar solvent.
In an embodiment of any disclosed dental whitening compositions, composition does not include suspended substance.
A kind of method for forming any disclosed dental whitening compositions is also provided herein comprising: merge hydrophobic Property copolymer, hydrophilic brighteners and polar solvent.
A kind of method on whitening teeth surface is also provided herein comprising: make dental surface and any disclosed tooth The contact of tooth Lightening compositions is enough to realize the duration of dental surface brightened.
In an embodiment of the method for whitening teeth surface, wherein dental surface and any disclosed tooth The contact of tooth Lightening compositions include formed include hydrophobic polymer and brightening agent hydrophobic film, and wherein described be enough The duration brightened for realizing dental surface includes making brightening agent from hydrophobic within about 5 minutes to about 12 hours a period of time Property membrane diffusion is to dental surface.
Other suitable application areas of the invention will be by detailed explanation provided below becomes apparent.It should be understood that specifically Although bright and specific example indicates some preferred aspects of the invention, it is intended only for the purpose of explanation, and is not intended to limit The scope of the present invention.
Specific embodiment
The explanation of various preferred aspects is merely exemplary in itself below, and be in no way intended to limit the present invention, The application or use of the invention.
The range used in the whole text is used as describing writing a Chinese character in simplified form for each value in the range.Any value in range all may be used To be chosen as range end point.In addition, all references cited herein is incorporated in entirety by reference hereby.If this public affairs The definition opened is clashed with the definition in cited bibliography, then is subject to the disclosure.
Unless otherwise defined, all percentages and amount expressed elsewhere herein and in specification should be understood as Refer to weight percent.Effective weight of the given amount based on material.
The term " hydrophobic " used applied to polymer and copolymer and herein refers to substantially non-aqueous And water solubility is lower than the organic polymer or copolymer of 0.1g/g water at pH8 and pH below.
Terms used herein " hydrophilic " have the standard meaning of affinity consistent in water with it.
As used herein, " film-forming composition " refers to dries after being applied to surface (for example, with solvent with composition Evaporation) and be precipitated out solution to leave deposited material or combination of materials film material or combination of materials.
As used herein, " oral cavity is acceptable " refer to be used safely in the composition of the disclosure, with reasonable interests/wind Danger ratio matches, brightening agent and the active constituent needed for other can associate therewith while keep the material or material group of remarkable efficacy It closes.
Dental whitening compositions
This document describes improved dental whitening compositions, with excellent film forming and brightening agent delivery properties.
In one embodiment, dental whitening compositions include: hydrophobic copolymer；Hydrophilic brighteners；And polarity Solvent.In one aspect, dental whitening compositions by weight include 0.1% to 60%, it is more preferable 1% to 30%, even more It is preferred that 2% to 25% hydrophobic copolymer.In one aspect, dental whitening compositions include by weight 0.01% to 40%, in one aspect, tooth increases more preferable 0.05% to 25%, even more preferably 0.08% to 20% hydrophilic brighteners White composition includes that 10% to 95%, more preferable 20% to 80%, even more preferably 30% to 70% polarity is molten by weight Agent.
Improved dental whitening compositions show good mouthfeel and dental whitening property.For example, in an embodiment party In formula, dental whitening compositions preferably do not include suspended substance and without solia particles.This is because the hydrophobic copolymer It may be dissolved in the polar solvent.Correspondingly, composition does not preferably include nonpolar solvent.Film-forming composition can use or It is delivered to dental surface in the case where without using applicator, and is preferably directly delivered and being rinsed in user mouthful.No matter Delivering method is how, and polar solvent can be volatile, so that when dental whitening compositions contact dental surface, enough Polar solvent can evaporate, to leave the film of hydrophobic copolymer (for example, film forming hydrophobic copolymer), hydrophilic brighteners It is embedded in wherein but can spread out and reach the enamel of tooth.In addition, the hydrophobic copolymer as used in preparation with The relative quantity of hydrophilic brighteners, therefore the dental whitening compositions provide hydrophobicity and hydrophilic well balanced.Namely Say, after the drying, composition be it is hydrophilic enough with effective in provide good whitening efficacy (for example, single treatment it DW variation discharges peroxide molecule to dental surface for amount 2) afterwards, and still hydrophobic enough for a long time (for example, long Up to 5 minutes or longer, such as up to 10 minutes or longer) retain on tooth surfaces appropriate location to provide lasting peroxidating Object delivers benefit.
Hydrophobic film-forming copolymer
In various embodiments, dental whitening compositions disclosed herein include that the hydrophobic film-forming with functional group is total Polymers, the functional group have the property provided to the good adhesion of dental surface.The example of such functional group includes but unlimited In: carboxylic acid, phosphate, hydroxyl, amine, disulphide, nitro etc..It is for example pungent that hydrophobic copolymer can be selected from carboxylated acrylonitrile acid copolymer The copolymer of base acrylamide and one or more monomers, the monomer include acrylic acid, methacrylic acid or its one kind or more Kind simple ester.The hydrophobic copolymer of dental whitening compositions can be acrylate/octylacrylamido.At one In embodiment, hydrophobic copolymer is preferably comprised copolymer (for example, 2,3 or 4 kind of monomer), such as 2- acrylic acid 2- methyl-, 2- methyl-prop base ester, the polymer (CAS with 2- acrylic acid and N- (1,1,3,3- tetramethyl butyl) -2- acrylamide It 129702-02-9), can be with79 derive from AkzoNobel Surface Chemistry LLC (Erie Noy state Chicago city).Other examples include but is not limited to4961、HC、2.0、RESYNTMXP is all from the (Illinois AkzoNobel Surface Chemistry LLC The Chicago Yi Zhou city).Hydrophobic copolymer is also selected from octyl acrylamide/acrylate/methacrylic acid butylamino second Ester copolymer, as AMPHOMER LV-71, AMPHOMER,EDGETM、47, From AkzoNobel Surface Chemistry LLC (Chicago, IL city).Hydrophobic copolymer also selected from VA/ butyl maleate/isobornyl acrylate copolymer such as comes from Ashland Global Specialty Chemicals Inc. the Advantage in (Winton city, Kentucky State section)TMPlus.Hydrophobic copolymer is also selected from acrylate/tert-butyl third Acrylamide copolymer, as from BASF SE (German rood Wei Bugang)Strong and8。 Hydrophobic copolymer such as comes from Evonik also selected from acrylate/dimethylaminoethyl methacrylate copolymer Industries's (Essen, Germany)Series polymer, such asE100、E PO、RS 100、RS PO、RL PO、RL 100 etc..Hydrophobicity is total Polymers such as comes from Ashland Global Specialty also selected from polyvinylpyrrolidone/vinyl acetate The PVP/VA series polymer of Chemicals Inc. (Winton city, Kentucky State section).Hydrophobic copolymer is also selected from melissane Base PVP such as comes from the Ganex in Ashland Global Specialty Chemicals Inc. (Winton city, Kentucky State section)TM WP-660.Hydrophobic copolymer can be selected from least one of following: octyl acrylamide/acrylate/methacrylic acid fourth Base amino ethyl ester copolymer, VA/ butyl maleate/isobornyl acrylate copolymer, acrylate/N-tert-butyl acrylamide are total Polymers, polyvinylpyrrolidone//vinyl acetate copolymers, melissyl PVP copolymer, acrylate/methacrylic acid two Methylamino methacrylate copolymers or their mixture.
In various embodiments, relative to the total weight of dental whitening compositions, hydrophobic copolymer is at most about The amount of 60 weight % is present in dental whitening compositions, including is greater than about 0 weight % to about 30 weight %, more preferably from about 5 weights Measure % to about 25 weight % or about 10 weight % to about 20 weight %, most preferably including the amount of about 15 weight %.
Hydrophilic brighteners
In various embodiments, dental whitening compositions disclosed herein include at least one brightening agent as activity at Point.In some embodiments, at least one brightening agent is peroxide compound.As discussed further below, " increase White dose " dental surface to be applied to it realizes the material that brightens.
As mentioned in this article, " peroxide compound " is comprising divalent oxygen-oxygen groups oxidized compound.Peroxidating Closing object includes peroxide and hydroperoxides, such as hydrogen peroxide, alkali and alkaline earth metal ions peroxide, organic peroxy chemical combination Object, peroxy acid, its pharmaceutically acceptable salt and its mixture.The peroxide of alkali and alkaline earth metal ions includes peroxidating Lithium, potassium peroxide, sodium peroxide, peromag, calper calcium peroxide, barium peroxide and their mixture.Organic peroxy chemical combination Object include urea peroxide (also referred to as perhydrit), glyceryl hydrogen peroxide, alkyl peroxide, dialkyl peroxide, Alkyl peroxy acids, peroxy esters, diacyl peroxide, benzoyl peroxide and monoperphthalic acid salt and its mixing Object.Peroxy acid and its salt include the organic peroxide acids such as alkyl peroxy acids and monoperphthalic acid salt and its mixture, with And the persulfates of the alkali and alkaline earth metal ions such as inorganic peracid salt, such as lithium, potassium, sodium, magnesium, calcium and barium, two persulfates, Percarbonate, perphosphate, perborate and persilicate and its mixture.In various embodiments, peroxidating materialization Closing object includes hydrogen peroxide, urea peroxide, SODIUM PERCARBONATE and its mixture.
It can be mentioned that for the peroxide release compound in dental whitening compositions disclosed herein include containing peroxide The compound of compound, such as urea peroxide, SODIUM PERCARBONATE, sodium perborate and polyvinylpyrrolidone-H2O2Compound is (hereinafter referred to as “PVP-H2O2").Polyvinylpyrrolidone is also referred to as the poly- 2-Pyrrolidone of poly-N-vinyl-and is commonly abbreviated as " PVP ". PVP is typically referred to containing vinyl pyrrolidone (also referred to as n-vinyl pyrrolidone, n-vinyl-2-pyrrolidone (N- Vinyl-2-pyrrolidione) and n-vinyl-2-pyrrolidone (N-vinyl-2-pyrrolidinone)) be used as monomer The polymer of unit.The monomeric unit is by a polarity imide group, four nonpolar methylene groups and a nonpolarity Methane group composition.
PVP-H2O2Linear and cross-linked composite be as known in the art, and PVP-H2O2It is considered in no water ring It is stable in border.When being exposed to height aqueous environments, such as in the oral cavity, PVP-H2O2Being dissociated into independent substance, (PVP is poly- Close object and H2O2).In one preferred embodiment, PVP-H2O2Compound be 80 weight % polyvinylpyrrolidone and The H of 20 weight %2O2。
In alternate embodiment disclosed herein, at least one brightening agent includes lipid peroxidation hydrogen solution. In general, liquid hydrogen peroxide is contained in the H in aqueous group water solution2O2(for example, the H of 35 weight %2O2Aqueous solution).
In various embodiments, relative to the total weight of dental whitening compositions, at least one brightening agent with The amount of at most about 40 weight % is present in dental whitening compositions, including about 0 weight % to about 40 weight %, including greater than about 0 weight % to about 30 weight %, more preferably from about 0.1 weight % to about 20 weight % or about 0.3 weight % to about 12 weight %, Amount including about 6 weight %.
In addition, at least one stabilizer can exist together with the composition comprising brightening agent.Stabilizer can be selected from such as chela Mixture, polyphosphate, peroxide stabiliser and free radical.In one embodiment, antifebrin or similar organic material Material can be used together with pyrophosphate stabilizer such as sodium acid pyrophosphate.In one embodiment, can be used has at least one The hydrogenperoxide steam generator of kind stabilizer is as brightening agent.
Polar solvent
In various embodiments, denture cleaning compositions disclosed herein include polar solvent.Selection polar solvent makes Hydrophobic copolymer can at least partly be dissolved by obtaining it.Polar solvent may include glycerol, propylene glycol, alcohol or water.
Preferably, polar solvent includes ethyl alcohol, such as to be enough to dissolve the ingredient of dental whitening compositions, particularly hydrophobic The amount of property polymer.In various embodiments, relative to the total weight of dental whitening compositions, polar solvent is at most about The amount of 99 weight % is present in dental whitening compositions, including is greater than about 0 weight % to about 99 weight %, more preferably from about 10 weights Measure % to about 95 weight % or about 20 weight % to about 80 weight %, most preferably including the amount of about 79 weight %.
Preferably, selection polar solvent makes it not react with brightening agent or only seldom react with brightening agent.For example, Know some polar solvents meeting peroxynitrite decomposition hydrogen and therefore shortens the shelf life for the dental whitening compositions covered herein.So And the decomposition of hydrogen peroxide is not necessarily by reacting generation with some polar solvents.For example, peroxide may occur from decomposing. Nevertheless, solvent incompatible in dental whitening compositions may accelerate the selfdecomposition of hydrogen peroxide.Correspondingly, including polarity Acceptable ingredient including solvent be to be formed can retain at aging 13 weeks for example at 40 DEG C 60% or more peroxide Those of dental whitening compositions of active matter.
Other ingredient
It also may include other compositions in Lightening compositions of the invention, and including such as surfactant, thickener, seasoning Agent, sweetener, desensitizer, antimicrobial, anti-caries agent, anti-calculus agent, anti-inflammatory agent, vitamin, pigment and colorant, enzyme Class, preservative, grinding agent and tartar control agents.
Can be used it is any take orally acceptable surfactant, major part is anionic, non-ionic or both sexes Type.Suitable anionic surfactant includes but is not limited to C8-20Alkyl sulfate, sulfonation C8-20Fatty mono glyceride Water soluble salt, sarcosinate, taurate etc..The illustrative example of these and other types include lauryl sodium sulfate, Sodium cocoglyceryl monoesters sodium sulfonate, sodium lauryl sarcosinate, sodium lauryl isethionate (sodium lauryl Isoethionate), laureth carbonyl acid sodium (sodium laureth carboxylate) and neopelex. Suitable nonionic surfactant includes but is not limited to poloxamer, polyoxyethylene sorbitan esters, fatty alcohol ethoxy Glycolylate, alkylphenol ethoxylate, tertiary amino oxides, phosphine oxides, dialkyl sulphoxide etc..Suitable amphoteric surface is living Property agent includes but is not limited to the C with anionic group (such as carbonyl acid group, sulfate radical, sulfonate radical, phosphate radical or phosphonate radical)8-20 The derivative of secondary aliphatic amine and tertiary amine.Suitable example is cocamidopropyl betaine.
In some embodiments, composition optionally includes thickener.The acceptable thickener in any oral cavity can be used, Including but not limited to: the also referred to as carbomer of carboxy vinyl polymer；Also referred to as Irish moss and more particularly carragheen The carrageenan of (iota- carragheen)；(such as CARBOWAX is available from Dow Chemical to high molecular weight polyethylene glycol Company)；Cellulosic polymer, such as hydroxyethyl cellulose, ethyl cellulose, carboxymethyl cellulose (CMC) and their salt, Such as CMC sodium；Natural gum, such as Karaya Gum, xanthan gum, gum arabic and bassora gum；Colloid silicic acid magnalium；And colloid And/or pyrogenic silica and their mixture.
In certain embodiments as disclosed herein, dental whitening compositions also may include at least one flavoring agent.It is described At least one flavoring agent can be selected, for example, from essential oil and various seasoning aldehydes, esters, alcohols and similar material.The example of essential oil Including spearmint, peppermint, Chinese ilex, sassafrases, cloves, Salvia japonica, eucalyptus, marjoram, cortex cinnamomi, lemon, bitter orange, grape fruit and The oil of orange.Such as menthol, Sheep's-parsley trunk and isoesdragol chemical substance are also applicable.In these, commonly used is Peppermint, spearmint and the oil of Chinese ilex.
In the embodiment for wherein making dental whitening compositions sweetened, at least one sweetener can be used as at least one tune The substitute or supplement of taste agent.Suitable sweetener can be water-soluble and including such as saccharin sodium, Cyclohexylamino sulphur Sour sodium, xylitol, peryllartine (perillartien), D-trp, Aspartame, dihydrochalcone and the like.
Exemplary antimicrobial may include those of usually used in oral care composition, such as Thymol；Benzene Methanol；Triclosan；Chlorhexidine；Tin salt, including mantoquita, zinc salt and tin salt, such as zinc oxide, zinc lactate, zinc citrate, sulphur Sour zinc, glycine zine, sodium citrate zinc and stannous pyrophosphate；Sanguinarine extract；Metronidazole；Quaternary ammonium compound, such as chlorination Hexadecane pyridine；Biguanides, such as chlorhexidine digluconate, hexatidine (hexetidine), Octenidine, A Lixi It is fixed；And halogenated bisphenolic compounds, such as 2,2 ' di-2-ethylhexylphosphine oxides (the chloro- 6- bromophenol of 4-).
Some embodiments of the disclosure include one or more pigment and/or one or more colorants.It can be used and appoint What the acceptable pigment in oral cavity and/or colorant, but should usually select the type of pigment and/or colorant, fineness (granularity) and Amount is so that will not excessive wear enamel in normal use dental whitening compositions.If it does, pigment and/or colorant Average particle size is typically about 0.1 to about 30 μm, for example, about 1 to about 20 μm or about 5 to about 15 μm.In one embodiment, face Material or colorant include TiO2 and/or ZnO.It can provide instant whitening effect comprising pigment and/or colorant, this is because for example The opacity of granules of pigments deposition on tooth surfaces from composition, while brightening agent from delivery of composition and enters Coloring is removed in enamel.
In various embodiments, any one of dental whitening compositions as described herein include anti-calculus agent. Suitable dental calculus preventing agent includes but is not limited to phosphate and Quadrafos (such as pyrophosphate), poly- aminopropanesulfonic acid (AMPS), hexametaphosphate, Zinc citrate trihydrate, polypeptide, polyolefm sulfonates, polyolefin phosphates, diphosphonate.? In some embodiments, the amount of anti-calculus agent is about 0.1% to about 30%w/w.In some embodiments, stable to brighten Dentrifice composition includes the mixture of anti-calculus agent.In some embodiments, by tetrapotassium pyrophosphate (TKPP), pyrophosphoric acid four Sodium (TSPP) and sodium tripolyphosphate (STPP) are used as anti-calculus agent.
Another desired other ingredient of dental whitening compositions of the invention is the poly- carboxylic of anionic polymer of synthesis Hydrochlorate (SAPP) serves as the stabilizer of polyphosphate anticalculus agent and can help to block pain or cause the substance such as sugar of pain And in dental nerve.
Exemplary anti-inflammatory agent may include in oral care composition usually using those of, such as brufen, Flurbiprofen, Aspirin and Indomethacin.Exemplary anti-caries agent may include ingredient such as below: sodium fluoride, calcirm-fluoride, magnesium fluoride and fluorine Change stannous, amine fluoride, sodium monofluorophosphate and sodium trimetaphosphate.Exemplary vitamin may include such as ascorbic ingredient.Show Example property desensitizer may include ingredient such as below: potassium citrate, potassium chloride, potassium tartrate, saleratus, potassium oxalate, nitric acid Potassium and strontium salt.Exemplary anti-calculus agent may include ingredient such as below: the burnt phosphorus including the alkali metal of mono-, di-, three and four Hydrochlorate and ammonium pyrophosphate and tripolyphosphate.Exemplary enzyme may include glucoamylase.
Some embodiments provide dental whitening compositions, and wherein at least one ingredient is fluorine ion selected from the following Source: stannous fluoride, sodium fluoride, potassium fluoride, sodium monofluorophosphate, prodan, ammonium fluosilicate, amine fluoride and ammonium fluoride.
There is disclosed herein be used to make one or the oral cavity of other animal subjects in whitening of dental surfaces method.It is a kind of Such method includes (a) for dental whitening compositions as disclosed herein being applied to dental surface to be brightened, every number of days Minute；(b) step (a) is repeated more days, thus whitening teeth.
Illustrative methods disclosed herein include making dental whitening compositions and tooth surface contact.In an embodiment In, contact of the dental surface with dental whitening compositions includes being formed on tooth surfaces comprising hydrophobic polymer and brightening agent Hydrophobic film.The contact sustainable duration for being enough satisfactorily to realize dental whitening.In one embodiment, foot To realize that the duration of whitening of dental surfaces includes making brightening agent from hydrophobicity within 2 minutes to about 24 hours a period of time Membrane diffusion is to dental surface.Therefore, the contact can be enough a period of time of at least partly whitening teeth.This can for A period of time in about 2 minutes to about 24 hours or longer ranges.In some embodiments, dental whitening compositions are dry (for example, the evaporation for passing through polar solvent) and the film that can be retained in dental surface the preceding paragraph time is formed, described a period of time exists About 2 minutes to about 24 hours, about 5 minutes to about 12 hours, about 10 minutes to about 8 hours or about 15 minutes to about 6 hours or In the range of about 30 minutes to about 4 hours or to be enough satisfactorily to realize a period of time of dental whitening.
In certain embodiments as disclosed herein, dental whitening compositions --- it can be substantially non-aqueous or can It is aqueous --- it can be within longer a period of time effectively, because it will not be in the oral cavity by significant dilute during handling the time It releases or washes away.Dental whitening compositions can as needed and when required by using standard dental hygiene procedures such as brush teeth or It is arbitrarily removed by being rinsed with spirituosity mouthwash.When in place, composition can slow, relative constant speed Rate and to be enough to realize that the concentration for removing coloring or dental whitening from tooth discharges agent contained therein.
There is disclosed herein the methods for preparing dental whitening compositions of the invention.In an example, disclosed herein Any one of dental whitening compositions can pass through the addition group in the stainless cylinder of steel that suitable container is such as provided with mixer It closes each ingredient of object and mixes to prepare.In the preparation of dental whitening compositions, ingredient can be in the following order or with any suitable Sequence is added to mixer: hydrophobic copolymer, hydrophilic brighteners, one of polar solvent and the other ingredient or It is a variety of.Then ingredient can be mixed to form to uniform composition.
In one embodiment, dental whitening compositions disclosed herein can be used for manufacturing and be allowed to exempt from for taking care of one's teeth In coloring, from bacterium invasion or for the oral care product of whitening teeth.
In one embodiment, dental whitening compositions disclosed herein can be prepared as flowable composition such as liquid The form of form or viscous liquid dispersion such as gel.In one embodiment, dental whitening compositions disclosed herein It for example can be used to take care of one's teeth and any aforementioned composition is administered to tooth and make it from coloring or invaded and harassed from bacterium Method in.
Dental whitening compositions are introducible directly into mouth, such as by rinsing (for example, user is in mouth as mouthwash Be vortexed composition like that).That is, it is preferable that the application of any dental whitening compositions leaves upper comprising hydrophobic The film of property copolymer and hydrophilic brighteners.
Alternatively, dental whitening compositions can be applied directly on the tooth of user with applicator, such as by being brushed with spreading Or it spreads pen and smears tooth.Correspondingly, at least one embodiment, packaging comprising any aforementioned dental whitening compositions with For applying the applicator of the composition to tooth.
Alternatively, dental whitening compositions can be applied directly to and composition to be placed on to substrate such as on band or mouth pallet On the tooth of user.For example, any one of above-mentioned dental whitening compositions can be fallen or be spread on the surface of substrate, Then substrate can be placed in the mouth of user so that composition and tooth surface contact.Substrate can retain in position Or can be removed, to leave at least some compositions on the surface of at least one tooth in user mouthful.
Embodiment
Embodiment 1
Prepare the Representative dental Lightening compositions according to formula as described herein.The dental whitening compositions include 10- 20%79 as hydrogen peroxide (35%) solution of hydrophobic copolymer and 0.3-12% as hydrophilic Property brightening agent (being available from Arkema, Inc. (village Pu Lushiwang, Pennsylvania)), remaining be alcohol purity be 200 it is anhydrous Ethyl alcohol (EtOH) (is available from the Pharmco-Products, (Kentucky Inc.d/b/a Pharmco-Aaper as polar solvent State Xie Erbiweier)).
By being added in rotation mixing wide-mouth bottle79 and EtOH prepares this to form mixture Composition.Then mixture is rotated to mixing four minutes under 3540rpm.Include into wide-mouth bottle79 It mixes with addition hydrogenperoxide steam generator in the mixture of EtOH and under 3540rpm until obtaining uniform clear solution.In table 1 The formula of gained dental whitening compositions is provided, including the ingredient lists listed of % by weight and total weight.
Embodiment 2
Prepare the another exemplary dental whitening compositions according to formula as described herein.The dental whitening compositions include 10-20%'sE100 is as hydrogen peroxide (35%) solution of hydrophobic copolymer and 0.3-12% as hydrophilic Property brightening agent (being available from Arkema, Inc. (village Pu Lushiwang, Pennsylvania)), remaining be alcohol purity be 200 it is anhydrous Ethyl alcohol (EtOH) (is available from the Pharmco-Products, (Kentucky Inc.d/b/a Pharmco-Aaper as polar solvent State Xie Erbiweier)).
By being added in rotation mixing wide-mouth bottleE100 and EtOH prepares the group to form mixture Close object.Then mixture is rotated to mixing four minutes under 3540rpm.Include into wide-mouth bottleE100 and EtOH Mixture in hydrogenperoxide steam generator is added and under 3540rpm mixing until obtaining uniform clear solution.It is provided in table 2 The formula of gained dental whitening compositions, including the ingredient lists listed of % by weight and total weight.
Embodiment 3- dental whitening
Using purchased from the artificial of Dental Product Testing Therametric Technologies, Inc. Color baurodont block (being mounted on the incisor in acrylic resin) assesses the whitening performance of the dental whitening compositions of embodiment 1.By three A L value is that the coloring baurodont block of 60-65 is cleaned and dried.L, a, b value are measured by MHT SpectroShade.Use nail polish Brush applies block teeth coated with the dental whitening compositions according to embodiment 1.Composition is air-dried 3-5 minutes to allow EtOH to steam Hair, thus leave be coated on block teeth comprising hydrogen peroxide and79 film.
Coated block teeth are immersed in artificial saliva in 12 orifice plates and are incubated under 37 DEG C and 100rpm of agitation Overnight.This allows at least some hydrogen peroxide to spread membrane and interact with block teeth.The next morning takes from artificial saliva Block teeth and by removing remaining film with ethanol out.Measure L, a, b value again using SpectroShade.Repeat this journey Sequence, so that block teeth receive five processing with film forming cleaning compositions.
Whitening performance is reported according to the following formula with variation (Δ W) of the W value compared with baseline value after per treatment:
W*=((a*)2+(b*)2+(L*-100)2)1/2With
Δ W*=W*Through handling-W*Baseline。
It handles for the first time Second of processing Third time is handled 4th processing 5th processing
Average delta W -3.79 -7.41 -8.18 -10.48 -15.25
Standard deviation 2.19 1.53 2.51 2.29 1.71
Embodiment 4- ageing research
Carry out the accelerated ageing of the dental whitening compositions of embodiment 1.The composition of embodiment 1 (is stored in 4 individually Pipe in) kept for 13 weeks at 40 DEG C in the laboratory with 75% humidity and active oxygen (AO%).After 13 weeks, 85.2% Active oxygen retains in the composition, shows that the peroxide molecule of composition is stable.
Shown in table 2 as above, the Δ W calculated after the 5th processing is -15.25.In contrast, than the combination of embodiment 1 The Δ W that there is object the conventional whitening gel of higher peroxide concentrations can reach about -12 after the processing in one to two week.Although no It is limited to any specific theory, it is believed that the dental whitening described herein comprising hydrophobic copolymer, brightening agent and polar solvent Composition (including the composition such as reported above with respect to embodiment 1) excellent whitening efficacy is attributed to the durable nature of its length (that is, long residence time)；That is, it forms film or coating to deliver the ability of brightening agent and such as by aging on the surface The result of research confirms its ability for controllably discharging brightening agent.In short, dental whitening compositions described herein is this The coating and film that long durability allows to be formed by it deliver within long a period of time and in the position close to dental surface Brightening agent such as hydrogen peroxide and from tooth remove stain molecules.
Other embodiments
In one aspect, a kind of method for forming dental whitening compositions is provided comprising: merge hydrophobicity copolymerization Object, hydrophilic brighteners and polar solvent.In an embodiment of this method, hydrophobic copolymer includes acrylate. In an embodiment of this method, hydrophobic copolymer is acrylate/octylacrylamido.In this method In one embodiment, hydrophobic copolymer includes 2- acrylic acid 2- methyl-, 2- methyl-prop base ester, has 2- acrylic acid and N- The polymer of (1,1,3,3- tetramethyl butyl) -2- acrylamide.In an embodiment of this method, hydrophobic copolymer Exist to be greater than about the amount of 0 weight % to about 30 weight %.In an embodiment of this method, hydrophilic brighteners include Peroxide.In an embodiment of this method, brightening agent includes hydrogen peroxide.In an embodiment of this method In, hydrophobic copolymer exists with the amount for being greater than about 0 weight % to about 12 weight %.In an embodiment of this method, Polar solvent includes ethyl alcohol.

Claims (20)

1. a kind of dental whitening compositions, the dental whitening compositions include:
Hydrophobic copolymer；
Hydrophilic brighteners；With
Polar solvent.
2. dental whitening compositions according to claim 1, wherein the hydrophobic copolymer includes acrylate.
3. dental whitening compositions according to any one of the preceding claims, wherein the hydrophobic copolymer is propylene Acid esters/octylacrylamido.
4. dental whitening compositions according to any one of the preceding claims, wherein the hydrophobic copolymer includes pungent Base acrylamide/acrylate/butylaminoethyl copolymer, VA/ butyl maleate/isobornyl acrylate Copolymer, acrylate/N-tert-butyl acrylamide copolymer, polyvinylpyrrolidone//vinyl acetate copolymers, melissyl PVP copolymer, acrylate/at least one of dimethylaminoethyl methacrylate copolymer or their mixture.
5. dental whitening compositions according to any one of the preceding claims, wherein the hydrophobic copolymer includes 2- Acrylic acid 2- methyl -, 2- methyl-prop base ester, with 2- acrylic acid and N- (1,1,3,3- tetramethyl butyl) -2- acrylamide Polymer.
6. dental whitening compositions according to any one of the preceding claims, wherein the hydrophobic copolymer is to be greater than The amount of about 0 weight % to about 30 weight % exists.
7. dental whitening compositions according to any one of the preceding claims, wherein the hydrophilic brighteners included Oxide.
8. dental whitening compositions according to any one of the preceding claims, wherein the brightening agent includes peroxidating Hydrogen.
9. dental whitening compositions according to any one of the preceding claims, wherein the hydrophobic copolymer is to be greater than The amount of about 0 weight % to about 12 weight % exists.
10. dental whitening compositions according to any one of the preceding claims, wherein the polar solvent includes ethyl alcohol.
11. dental whitening compositions according to any one of the preceding claims, wherein the composition is that oral cavity can connect The composition received.
12. dental whitening compositions according to any one of the preceding claims, wherein the composition is film forming combination Object.
13. dental whitening compositions according to any one of the preceding claims, wherein the composition is in liquid form.
14. dental whitening compositions according to any one of the preceding claims, wherein the composition is in gel form.
15. dental whitening compositions according to any one of the preceding claims, wherein the composition does not include non-pole Property solvent.
16. dental whitening compositions according to any one of the preceding claims suspend wherein the composition does not include Body.
17. dental whitening compositions according to any one of the preceding claims, wherein the hydrophobic copolymer includes Hydrophobic film-forming copolymer, the hydrophobic film-forming copolymer include the functional group for being configured to adhere to dental surface.
18. a kind of method for forming dental whitening compositions according to any one of the preceding claims, the method packet It includes:
Merge the hydrophobic copolymer, the hydrophilic brighteners and the polar solvent.
19. a kind of method for whitening teeth surface, which comprises
The dental surface is set to be enough to realize with contacting to dental whitening compositions described in any one of 17 according to claim 1 The duration of the dental surface brightened.
20. according to the method for claim 19, wherein the dental surface connects with the described of the dental whitening compositions Touching include formed include the hydrophobic polymer and the brightening agent hydrophobic film, and wherein it is described be enough to realize it is described The duration of dental surface brightened includes making the brightening agent from described within about 5 minutes to about 12 hours a period of time Hydrophobic film diffuses to the dental surface.
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