CN110217819A - A kind of one-step synthesis of spherical hollow mesoporous bismuth sulfide/silica nano material - Google Patents
A kind of one-step synthesis of spherical hollow mesoporous bismuth sulfide/silica nano material Download PDFInfo
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
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- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y40/00—Manufacture or treatment of nanostructures
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- C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
- C01B33/00—Silicon; Compounds thereof
- C01B33/113—Silicon oxides; Hydrates thereof
- C01B33/12—Silica; Hydrates thereof, e.g. lepidoic silicic acid
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- C01P2002/80—Crystal-structural characteristics defined by measured data other than those specified in group C01P2002/70
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- C01P2004/00—Particle morphology
- C01P2004/30—Particle morphology extending in three dimensions
- C01P2004/32—Spheres
- C01P2004/34—Spheres hollow
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- C01P2006/17—Pore diameter distribution
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- C01P2006/80—Compositional purity
Abstract
The present invention relates to hollow Nano biomaterial preparation technical fields, more specifically, are related to a kind of one-step synthesis of spherical hollow mesoporous bismuth sulfide/silica nano material.Using ethyl orthosilicate, surfactant, albumin, inorganic bismuth source, dust technology, sodium hydroxide, ammonium nitrate, dehydrated alcohol as raw material, is rejected by thermostatic crystallization, template, centrifuge separation, hollow mesoporous Bi is made2S3/SiO2Nano material material, to increase substantially Bi2S3/SiO2The purity of nano material expands Bi2S3/SiO2Applications to nanostructures range.This technical process is a kind of quick, hollow mesoporous Bi of controlledly synthesis2S3/SiO2The technique of nano material can be realized by the additive amount of surfactant, ethyl orthosilicate and albumin in change synthetic system to hollow mesoporous Bi2S3/SiO2The controllable adjustment of the microspherulite diameter of nano material, voided layer thickness.Hollow mesoporous Bi made from the method for the present invention2S3/SiO2Nano material property is as follows: partial size 80~150nm, hollow 10~20nm of outer layer thickness, and product purity reaches 99.9%.
Description
Technical field
The present invention relates to hollow Nano biomaterial preparation technical fields, more specifically, are related to a kind of spherical hollow Jie
Hole bismuth sulfide/silica nano material one-step synthesis.
Background technique
Cancer is one of the major disease that precisely medical treatment is mainly captured at present, is carried out using molecular image technology to tumour early
Phase diagnosis and boundary refine, and construct personalized treatment, it is expected under the influence of low side effect, realize to the efficient accurate of cancer
Diagnosis and treatment.As nanotechnology is risen, using nano material characteristic, the application field of molecular image technology is expanded, realizes nanometer material
Expect the application in terms of disease treatment, be not only of great significance to molecular image technology, but also is exploitation novel cancer
Means provide new era.
Currently, there are many nano-probes to realize clinical conversion, due to tumor tissues medium vessels are abundant, vascular wall gap compared with
Width, poor structural integrity, nano material can be enriched in tumor locus by Thief zone and long retention effect (EPR).Researcher's hair
Existing, size has good passive target effect in the nano particle of 50-100nm, and circulation time is relatively long in vivo, can
Enter lesions position by the gap that blood vessel dynamic aperture " intermittence eruption " generates, subsequent gap is gradually closed, and promotes large scale
Nano particle is detained in inside, reduces clearance rate, nano particle is substantially improved in the deposition of lesions position.
Hollow structure mesopore silicon oxide (HMSN) has biggish specific surface area and hollow structure inside, and medicine can be substantially improved
Object useful load, meanwhile, outer shell density is lower, is conducive to degrade rapidly in vivo, be metabolized, internal accumulation is effectively reduced
Toxicity.Silica is regarded as " GenerallyRecognizedAsSafe " (GRAS) by U.S. FDA, is widely used in taking orally
The drugs such as reagent, HMSN provide a kind of new approaches as a kind of preferred material, for nano material biomedicine research and development application.So
And construct hollow mesoporous monox nanometer particle at present and mostly use substep synthesis mode, preparation process is complicated, variable factor compared with
It is more, it is not easy large-scale production, strongly limits its further investigation and clinical conversion.
Summary of the invention
In the presence of overcoming the shortcomings of the prior art, the present invention provides that a kind of synthesis step is simple, product structure is easy
Control, the spherical hollow mesoporous Bi that product purity can be substantially improved2S3/SiO2One-step synthesis.
In order to solve the above-mentioned technical problem, the technical scheme adopted by the invention is as follows:
A kind of one-step synthesis of spherical hollow mesoporous bismuth sulfide/silica nano material, comprising the following steps:
S1, by deionized water: surfactant: albumin is according to 277.778~555.556:0.082~0.329:
2.257·10-3~6.02010-3Molar ratio at mixed solution, 5~15min is stirred at 30 DEG C；
S2, inorganic bismuth source is dissolved in the dust technology that concentration is 2mol/L, is added dropwise in S1 and mixes after sufficiently dissolving dispersion
It closes in solution, 10~20min of high-speed stirred；Inorganic bismuth source and dust technology molar ratio are 0.024~0.198:1.6~2.4
S3, into S2, the sodium hydroxide solution that concentration is 2mol/L is added dropwise in mixed solution, and adjustment pH value is permanent at 12,37 DEG C
10~30h of temperature stirring；
S4, into S3, ethyl orthosilicate is slowly added dropwise in mixed solution, sealing, and constant temperature stirs 20~40h at 37 DEG C；It is described just
Silester and surfactant molar ratio are 1.307~6.533:0.082~0.329；
S5, mixed solution in S4 is washed, centrifugation, freeze-drying through deionized water, is not gone the hollow of template agent removing
Mesoporous Bi2S3/SiO2Nano material；
S6, according to the hollow mesoporous Bi for not removing template agent removing2S3/SiO2: ammonium nitrate: dehydrated alcohol=0.5~1:5~25:
Ammonium nitrate is added to absolute ethanol to be added after forming mixed solution and does not go the hollow of template agent removing by 1000~2000 mass ratio
Mesoporous Bi2S3/SiO2, sufficiently after dissolution dispersion, 2~6h is stirred at 60 DEG C, mixture is made；
S7, mixture in S6 is successively separated by solid-liquid separation, deionized water washing, drying, repeats above step three times, obtains
To hollow mesoporous Bi2S3/SiO2Nano material.
Preferably, the surfactant is cetyl trimethylammonium bromide.
Preferably, the albumin is bovine serum albumin(BSA).
Preferably, the inorganic bismuth source is five nitric hydrate bismuths.
Preferably, S2 high speed stirring uses ultrasonic disperse instrument, frequency 59KHz.
Preferably, dissolution dispersion uses ultrasonic disperse instrument, frequency 59KHz, jitter time 5min in S6.
Compared with prior art, the advantageous effect of present invention is that:
The present invention provides a kind of one-step synthesis of spherical hollow mesoporous bismuth sulfide/silica nano material, with white
Albumen and surfactant are as template, by adding to surfactant, ethyl orthosilicate and albumin in synthetic system
Amount carries out modulation and compensates for conventional method to reach the structure optimization to hollow Nano particle and prepare hollow meso-porous titanium dioxide
The cumbersome defect with the more difficult regulation of grain structure of the preparation process multistep of silicon, synthetic method is simple and easy, is greatly improved
Bi2S3/SiO2The purity of nano material expands Bi2S3/SiO2Applications to nanostructures range, be a very ideal step quickly,
The hollow mesoporous Bi of controllable preparation2S3/SiO2The method of nano material.
Detailed description of the invention
Fig. 1 is hollow mesoporous Bi2S synthesized by the embodiment of the present invention 13/SiO2The XRD spectra of nano material.
Fig. 2 is hollow mesoporous Bi2S synthesized by the embodiment of the present invention 13/SiO2The TEM of nano material schemes.
Fig. 3 is hollow mesoporous Bi2S synthesized by the embodiment of the present invention 13/SiO2The nitrogen adsorption of nano material-desorption spectrum
Figure.
Fig. 4 is hollow mesoporous Bi2S synthesized by the embodiment of the present invention 13/SiO2The graph of pore diameter distribution of nano material.
Fig. 5 is hollow mesoporous Bi2S synthesized by the embodiment of the present invention 13/SiO2The XPS spectrum figure of nano material.
Specific embodiment
Following will be combined with the drawings in the embodiments of the present invention, and technical solution in the embodiment of the present invention carries out clear, complete
Site preparation description, it is clear that described embodiments are only a part of the embodiments of the present invention, instead of all the embodiments.It is based on
Embodiment in the present invention, it is obtained by those of ordinary skill in the art without making creative efforts every other
Embodiment shall fall within the protection scope of the present invention.
Embodiment 1
Taking concentration is 65% nitric acid 138.6mL, deionized water 806mL, and beaker is added together and is sufficiently mixed, by mixed liquor
It moves in volumetric flask, it is spare to be made into the nitric acid solution that concentration is 2moL/L；
Sodium hydroxide 83.33g, deionized water 1L are taken, beaker is added together and is sufficiently mixed, mixed liquor is moved into volumetric flask
In, it is spare to be made into the sodium hydroxide solution that concentration is 2moL/L；
Ionized water 120mL, bovine serum albumin(BSA) 3.750g are removed, cetyl trimethylammonium bromide 1.05g is added together
In beaker, 30 DEG C of stirring 10min form clear solution；Five nitric hydrate bismuth 0.36g are taken to be dissolved in the nitric acid solution of 15mL2moL/L
Afterwards, it is added in mixed solution, is placed in ultrasonic wave separating apparatus and carries out dissolution dispersion, frequency 59KHz, jitter time 10min；It utilizes
The pH of mixed solution is adjusted to 12 by the sodium hydroxide solution prepared in advance, is heated to 37 DEG C of constant temperature stirring 15h, solution is by transparent
Become brownish black；
Ethyl orthosilicate 15mL is taken, is slowly added dropwise into brownish black mixed solution, is sealed, 37 DEG C of constant temperature stir 30h；Product
Through deionized water washing, centrifugation, freeze-drying, the hollow mesoporous Bi of template agent removing is not removed2S3/SiO2Nano material.
The hollow mesoporous Bi for not removing template agent removing after weighing drying2S3/SiO2Nano material 1.0g, ammonium nitrate 25g, with
Ethyl alcohol 2.5L is added in beaker together, is placed in ultrasonic wave separating apparatus and is carried out dissolution dispersion, frequency 59KHz, jitter time
5min.It is heated to 60 DEG C of constant temperature stirring 3h later, obtains hollow mesoporous Bi2S3/SiO2Nano material.
Fig. 1 is hollow mesoporous Bi2S synthesized by the present embodiment3/SiO2The nano material of the XRD spectra synthesis of nano material
Show its distinctive characteristic diffraction peak.
Fig. 2 is hollow mesoporous Bi2S synthesized by the present embodiment3/SiO2The TEM of nano material schemes, and a is 100nm mark in figure
TEM under ruler schemes, and b is the TEM figure under 50nm scale in figure.Synthesized nano material is evenly distributed as seen from the figure, during pattern is
It is empty spherical.
Fig. 3 is hollow mesoporous Bi2S synthesized by the present embodiment3/SiO2The nitrogen adsorption of nano material-desorption spectrogram.It inhales
Attached-desorption isotherm shows as IV type curve, in the lower section (P/P of relative partial pressure0=0.08~0.21) it is solidifying that there are capillarys
Poly- phenomenon, it was demonstrated that material has uniform duct.
Fig. 4 is hollow mesoporous Bi2S synthesized by the present embodiment3/SiO2The graph of pore diameter distribution of nano material.In desorption branch
The pore-size distribution being calculated using BJH model is relatively narrow, and average pore size is about 3.1nm.
Fig. 5 is hollow mesoporous Bi2S synthesized by the present embodiment3/SiO2The XPS spectrum figure of nano material.As seen from the figure, exist
The peak XPS corresponds to Bi at 159.0 and 164.1eV2S3The peak Bi4F7/2 and 4F5/2 of nano particle, 2p peak of the S at 163.5eV by
BSA stable Bi2S3Bi and S, which is combined, in nanoparticle generates.
Embodiment 2
Taking concentration is 65% nitric acid 138.6mL, deionized water 806mL, and beaker is added together and is sufficiently mixed, by mixed liquor
It moves in volumetric flask, it is spare to be made into the nitric acid solution that concentration is 2moL/L；
Sodium hydroxide 83.33g, deionized water 1L are taken, beaker is added together and is sufficiently mixed, mixed liquor is moved in volumetric flask,
It is spare to be made into the sodium hydroxide solution that concentration is 2moL/L；
Ionized water 75mL, bovine serum albumin(BSA) 2.250g are removed, cetyl trimethylammonium bromide 0.45g is added together
In beaker, 30 DEG C of stirring 5min form clear solution；Five nitric hydrate bismuth 0.18g are taken to be dissolved in the nitric acid solution of 12mL2moL/L
Afterwards, it is added in mixed solution, is placed in ultrasonic wave separating apparatus and carries out dissolution dispersion, frequency 59KHz, jitter time 10min；It utilizes
The pH of mixed solution is adjusted to 12 by the sodium hydroxide solution prepared in advance, is heated to 37 DEG C of constant temperature stirring 10h, solution is by transparent
Become brownish black；
Ethyl orthosilicate 4.5mL is taken, is slowly added dropwise into brownish black mixed solution, is sealed, 37 DEG C of constant temperature stir 20h；It produces
Object is washed through deionized water, centrifugation, is freeze-dried, and is not removed the hollow mesoporous Bi of template agent removing2S3/SiO2Nano material.
The hollow mesoporous Bi for not removing template agent removing after weighing drying2S3/SiO2Nano material 0.5g, ammonium nitrate 6g, with second
Alcohol 1.5L is added in beaker together, is placed in ultrasonic wave separating apparatus and is carried out dissolution dispersion, frequency 59KHz, jitter time 5min.
It is heated to 60 DEG C of constant temperature stirring 2h later, obtains hollow mesoporous Bi2S3/SiO2Nano material.
Embodiment 3
Taking concentration is 65% nitric acid 138.6mL, deionized water 806mL, and beaker is added together and is sufficiently mixed, by mixed liquor
It moves in volumetric flask, it is spare to be made into the nitric acid solution that concentration is 2moL/L；
Sodium hydroxide 83.33g, deionized water 1L are taken, beaker is added together and is sufficiently mixed, mixed liquor is moved into volumetric flask
In, it is spare to be made into the sodium hydroxide solution that concentration is 2moL/L；
Ionized water 150mL, bovine serum albumin(BSA) 6.000g are removed, cetyl trimethylammonium bromide 1.80g is added together
In beaker, 30 DEG C of stirring 15min form clear solution；Five nitric hydrate bismuth 1.44g are taken to be dissolved in the nitric acid solution of 18mL2moL/L
Afterwards, it is added in mixed solution, is placed in ultrasonic wave separating apparatus and carries out dissolution dispersion, frequency 59KHz, jitter time 10min；It utilizes
The pH of mixed solution is adjusted to 12 by the sodium hydroxide solution prepared in advance, is heated to 37 DEG C of constant temperature stirring 30h, solution is by transparent
Become brownish black；
Ethyl orthosilicate 22.5mL is taken, is slowly added dropwise into brownish black mixed solution, is sealed, 37 DEG C of constant temperature stir 40h；It produces
Object is washed through deionized water, centrifugation, is freeze-dried, and is not removed the hollow mesoporous Bi of template agent removing2S3/SiO2Nano material.
The hollow mesoporous Bi for not removing template agent removing after weighing drying2S3/SiO2Nano material 1.5g, ammonium nitrate 40g, with
Ethyl alcohol 4.0L is added in beaker together, is placed in ultrasonic wave separating apparatus and is carried out dissolution dispersion, frequency 59KHz, jitter time
5min.It is heated to 60 DEG C of constant temperature stirring 6h later, obtains hollow mesoporous Bi2S3/SiO2Nano material.
Embodiment 4
Taking concentration is 65% nitric acid 138.6mL, deionized water 806mL, and beaker is added together and is sufficiently mixed, by mixed liquor
It moves in volumetric flask, it is spare to be made into the nitric acid solution that concentration is 2moL/L；
Sodium hydroxide 83.33g, deionized water 1L are taken, beaker is added together and is sufficiently mixed, mixed liquor is moved into volumetric flask
In, it is spare to be made into the sodium hydroxide solution that concentration is 2moL/L；
Ionized water 120mL, bovine serum albumin(BSA) 3.750g are removed, cetyl trimethylammonium bromide 1.05g is added together
In beaker, 30 DEG C of stirring 10min form clear solution；Five nitric hydrate bismuth 0.36g are taken to be dissolved in the nitric acid solution of 15mL2moL/L
Afterwards, it is added in mixed solution, is placed in ultrasonic wave separating apparatus and carries out dissolution dispersion, frequency 59KHz, jitter time 10min；It utilizes
The pH of mixed solution is adjusted to 12 by the sodium hydroxide solution prepared in advance, is heated to 37 DEG C of constant temperature stirring 15h, solution is by transparent
Become brownish black；
Ethyl orthosilicate 18mL is taken, is slowly added dropwise into brownish black mixed solution, is sealed, 37 DEG C of constant temperature stir 30h；Product
Through deionized water washing, centrifugation, freeze-drying, the hollow mesoporous Bi of template agent removing is not removed2S3/SiO2Nano material.
The hollow mesoporous Bi for not removing template agent removing after weighing drying2S3/SiO2Nano material 1.2g, ammonium nitrate 35g, with
Ethyl alcohol 3.1L is added in beaker together, is placed in ultrasonic wave separating apparatus and is carried out dissolution dispersion, frequency 59KHz, jitter time
5min.It is heated to 60 DEG C of constant temperature stirring 3h later, obtains hollow mesoporous Bi2S3/SiO2Nano material.
Embodiment 5
Taking concentration is 65% nitric acid 138.6mL, deionized water 806mL, and beaker is added together and is sufficiently mixed, by mixed liquor
It moves in volumetric flask, it is spare to be made into the nitric acid solution that concentration is 2moL/L；
Sodium hydroxide 83.33g, deionized water 1L are taken, beaker is added together and is sufficiently mixed, mixed liquor is moved into volumetric flask
In, it is spare to be made into the sodium hydroxide solution that concentration is 2moL/L；
Ionized water 120mL, bovine serum albumin(BSA) 3.750g are removed, cetyl trimethylammonium bromide 0.6g is added together
In beaker, 30 DEG C of stirring 10min form clear solution；Five nitric hydrate bismuth 0.36g are taken to be dissolved in the nitric acid solution of 15mL2moL/L
Afterwards, it is added in mixed solution, is placed in ultrasonic wave separating apparatus and carries out dissolution dispersion, frequency 59KHz, jitter time 10min；It utilizes
The pH of mixed solution is adjusted to 12 by the sodium hydroxide solution prepared in advance, is heated to 37 DEG C of constant temperature stirring 15h, solution is by transparent
Become brownish black；
Ethyl orthosilicate 15mL is taken, is slowly added dropwise into brownish black mixed solution, is sealed, 37 DEG C of constant temperature stir 30h；Product
Through deionized water washing, centrifugation, freeze-drying, the hollow mesoporous Bi of template agent removing is not removed2S3/SiO2Nano material.
The hollow mesoporous Bi for not removing template agent removing after weighing drying2S3/SiO2Nano material 0.8g, ammonium nitrate 20g, with
Ethyl alcohol 2L is added in beaker together, is placed in ultrasonic wave separating apparatus and is carried out dissolution dispersion, frequency 59KHz, jitter time 5min.
It is heated to 60 DEG C of constant temperature stirring 3h later, obtains hollow mesoporous Bi2S3/SiO2Nano material.
Embodiment 6
Taking concentration is 65% nitric acid 138.6mL, deionized water 806mL, and beaker is added together and is sufficiently mixed, by mixed liquor
It moves in volumetric flask, it is spare to be made into the nitric acid solution that concentration is 2moL/L；
Sodium hydroxide 83.33g, deionized water 1L are taken, beaker is added together and is sufficiently mixed, mixed liquor is moved into volumetric flask
In, it is spare to be made into the sodium hydroxide solution that concentration is 2moL/L；
Ionized water 120mL, bovine serum albumin(BSA) 4.500g are removed, cetyl trimethylammonium bromide 1.2g is added together
In beaker, 30 DEG C of stirring 10min form clear solution；Five nitric hydrate bismuth 0.36g are taken to be dissolved in the nitric acid solution of 15mL2moL/L
Afterwards, it is added in mixed solution, is placed in ultrasonic wave separating apparatus and carries out dissolution dispersion, frequency 59KHz, jitter time 10min；It utilizes
The pH of mixed solution is adjusted to 12 by the sodium hydroxide solution prepared in advance, is heated to 37 DEG C of constant temperature stirring 15h, solution is by transparent
Become brownish black；
Ethyl orthosilicate 10mL is taken, is slowly added dropwise into brownish black mixed solution, is sealed, 37 DEG C of constant temperature stir 30h；Product
Through deionized water washing, centrifugation, freeze-drying, the hollow mesoporous Bi of template agent removing is not removed2S3/SiO2Nano material.
The hollow mesoporous Bi for not removing template agent removing after weighing drying2S3/SiO2Nano material 1.0g, ammonium nitrate 20g, with
Ethyl alcohol 2.2L is added in beaker together, is placed in ultrasonic wave separating apparatus and is carried out dissolution dispersion, frequency 59KHz, jitter time
5min.It is heated to 60 DEG C of constant temperature stirring 3h later, obtains hollow mesoporous Bi2S3/SiO2Nano material.
Hollow mesoporous Bi made from the method for the present invention2S3/SiO2Nano material property is as follows: partial size 80~150nm, hollow
10~20nm of outer layer thickness, product purity reach 99.9%.
Only presently preferred embodiments of the present invention is explained in detail above, but the present invention is not limited to above-described embodiment,
Within the knowledge of a person skilled in the art, it can also make without departing from the purpose of the present invention each
Kind variation, various change should all be included in the protection scope of the present invention.
Claims (6)
1. a kind of one-step synthesis of spherical hollow mesoporous bismuth sulfide/silica nano material, which is characterized in that including following
Step:
S1, by deionized water: surfactant: albumin is according to 277.778~555.556:0.082~0.329:2.257
10-3~6.02010-3Molar ratio at mixed solution, 5~15min is stirred at 30 DEG C；
It S2, according to inorganic bismuth source and nitric acid molar ratio is 0.024~0.198:1.6~2.4, inorganic bismuth source, which is dissolved in concentration, is
In the dust technology of 2mol/L, to be added dropwise in S1 in mixed solution after completely dissolution, 10~20min of high-speed stirred；
S3, into S2, the sodium hydroxide solution that concentration is 2mol/L is added dropwise in mixed solution, and adjustment mixed solution pH value is 12,37 DEG C
Lower constant temperature stirs 10~30h；
S4, according to ethyl orthosilicate and surfactant molar ratio it is 1.307~6.533:0.082~0.329, is mixed into S3
Ethyl orthosilicate is slowly added dropwise in solution, sealing, and constant temperature stirs 20~40h at 37 DEG C；
S5, mixed solution in S4 is washed, centrifugation, freeze-drying through deionized water, is not gone the hollow mesoporous of template agent removing
Bi2S3/SiO2Nano material；
S6, according to the hollow mesoporous Bi2S for not removing template agent removing3/SiO2: ammonium nitrate: dehydrated alcohol=0.5~1:5~25:1000
Ammonium nitrate is added to absolute ethanol to be added after forming mixed solution and does not go the hollow mesoporous of template agent removing by~2000 mass ratio
Bi2S3/SiO2, sufficiently after dissolution dispersion, 2~6h is stirred at 60 DEG C, mixture is made；
S7, mixture in S6 is successively separated by solid-liquid separation, deionized water washing, drying, repeats above step three times, obtains sky
The mesoporous Bi of the heart2S3/SiO2Nano material.
2. the one-step synthesis of the spherical hollow mesoporous bismuth sulfide/silica nano material of one kind according to claim 1,
It is characterized by: the surfactant is cetyl trimethylammonium bromide.
3. the one-step synthesis of the spherical hollow mesoporous bismuth sulfide/silica nano material of one kind according to claim 1,
It is characterized by: the albumin is bovine serum albumin(BSA).
4. the one-step synthesis of the spherical hollow mesoporous bismuth sulfide/silica nano material of one kind according to claim 1,
It is characterized by: the inorganic bismuth source is five nitric hydrate bismuths.
5. the one-step synthesis of the spherical hollow mesoporous bismuth sulfide/silica nano material of one kind according to claim 1,
It is characterized by: the S2 high speed stirring uses ultrasonic disperse instrument, frequency 59KHz.
6. the one-step synthesis of the spherical hollow mesoporous bismuth sulfide/silica nano material of one kind according to claim 1,
It is characterized by: dissolution dispersion uses ultrasonic disperse instrument, frequency 59KHz, jitter time 5min in the S6.
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| CN201910583397.4A CN110217819B (en) | 2019-07-01 | 2019-07-01 | One-step synthesis method of spherical hollow mesoporous bismuth sulfide/silicon dioxide nano material |
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| CN112408404A (en) * | 2020-11-26 | 2021-02-26 | 山西医科大学 | One-step synthesis method of degradable rod-like mesoporous silica nano material |
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| CN112408404A (en) * | 2020-11-26 | 2021-02-26 | 山西医科大学 | One-step synthesis method of degradable rod-like mesoporous silica nano material |
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