CN110215601B - Blood brain barrier opening monitoring method, system and storage medium - Google Patents
Blood brain barrier opening monitoring method, system and storage medium Download PDFInfo
- Publication number
- CN110215601B CN110215601B CN201910515414.0A CN201910515414A CN110215601B CN 110215601 B CN110215601 B CN 110215601B CN 201910515414 A CN201910515414 A CN 201910515414A CN 110215601 B CN110215601 B CN 110215601B
- Authority
- CN
- China
- Prior art keywords
- magnetic resonance
- target object
- brain barrier
- ultrasonic
- blood brain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0033—Features or image-related aspects of imaging apparatus classified in A61B5/00, e.g. for MRI, optical tomography or impedance tomography apparatus; arrangements of imaging apparatus in a room
- A61B5/004—Features or image-related aspects of imaging apparatus classified in A61B5/00, e.g. for MRI, optical tomography or impedance tomography apparatus; arrangements of imaging apparatus in a room adapted for image acquisition of a particular organ or body part
- A61B5/0042—Features or image-related aspects of imaging apparatus classified in A61B5/00, e.g. for MRI, optical tomography or impedance tomography apparatus; arrangements of imaging apparatus in a room adapted for image acquisition of a particular organ or body part for the brain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/02028—Determining haemodynamic parameters not otherwise provided for, e.g. cardiac contractility or left ventricular ejection fraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/026—Measuring blood flow
- A61B5/0263—Measuring blood flow using NMR
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/48—Other medical applications
- A61B5/4836—Diagnosis combined with treatment in closed-loop systems or methods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0092—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin using ultrasonic, sonic or infrasonic vibrations, e.g. phonophoresis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2210/00—Anatomical parts of the body
- A61M2210/06—Head
- A61M2210/0693—Brain, cerebrum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2230/00—Measuring parameters of the user
Abstract
The embodiment of the invention discloses a method and a system for monitoring blood brain barrier opening and a storage medium. The monitoring method comprises the following steps: controlling an ultrasonic emission device to emit based on a first ultrasonic power, controlling a magnetic resonance device to acquire a first magnetic resonance image of a target object, and determining a first vascular dynamics parameter of the target object according to the first magnetic resonance image; controlling an ultrasonic emission device to emit based on the second ultrasonic power, controlling a magnetic resonance device to acquire a second magnetic resonance image of the target object, and determining a second vascular dynamics parameter of the target object according to the second magnetic resonance image; and determining whether the blood brain barrier of the target object is open according to the first vessel dynamics parameter and the second vessel dynamics parameter. According to the embodiment of the invention, the vessel dynamics parameters are determined through the magnetic resonance images of the target object under different ultrasonic powers, and whether the blood brain barrier is opened or not is determined according to the vessel dynamics parameters, so that the blood brain barrier can be opened effectively and safely, and the equipment cost is saved.
Description
Technical Field
The embodiment of the invention relates to the technical field of blood brain barrier opening induced by ultrasound, in particular to a method and a system for monitoring blood brain barrier opening and a storage medium.
Background
The blood brain barrier is a physiological barrier between brain tissue and peripheral circulatory system, can prevent harmful substances in the circulatory system from entering the brain tissue, and has important biological significance for maintaining the stable environment in the brain and the normal physiological state of the central nervous system.
The traditional therapy of brain functional diseases mainly comprises medicines, operations or psychological guidance and the like, the traditional surgical treatment is invasive treatment, and has the problems of difficult accurate positioning or difficult repeated implementation and the like, and simultaneously, due to the existence of blood brain barrier, the chemical medicine has low effect efficiency, and patients who receive the medicine treatment for a long time are easy to generate medicine tolerance, addiction and toxic and side effects. In the prior art, an imaging probe or a hydrophone is utilized to detect cavitation activity of brain ultrasonic action transcranially in the blood brain barrier opening process, the imaging probe is required to have high sensitivity and wide imaging bandwidth, the imaging probe is expensive in manufacturing cost, in addition, the imaging probe of a single array element lacks space resolution, the imaging probe of multiple array elements can realize monitoring of a selected layer, but the position and sensitivity configuration of each array element has high requirements, and an imaging system is complex.
Disclosure of Invention
The embodiment of the invention provides a method and a system for monitoring blood brain barrier opening and a storage medium, which are used for effectively and safely opening the blood brain barrier, globally monitoring the blood brain barrier opening process with multiple layers and high spatial resolution and simultaneously saving equipment cost.
In a first aspect, an embodiment of the present invention provides a method for monitoring blood-brain barrier opening, where the method includes:
controlling an ultrasonic emission device to emit based on first ultrasonic power, controlling a magnetic resonance device to acquire a first magnetic resonance image of a target object, and determining a first blood vessel kinetic parameter of the target object according to the first magnetic resonance image, wherein the first ultrasonic power is less than standard power for causing blood brain barrier opening;
controlling the ultrasonic emission device to emit based on a second ultrasonic power, controlling the magnetic resonance device to acquire a second magnetic resonance image of a target object, and determining a second vascular dynamics parameter of the target object according to the second magnetic resonance image, wherein the second ultrasonic power is greater than the first ultrasonic power;
determining whether the blood brain barrier of the target object is open according to the first and second vessel dynamics parameters.
Further, determining whether the blood brain barrier of the target object is open according to the first vessel dynamics parameter and the second vessel dynamics parameter includes:
determining whether a difference in the first and second hemodynamic parameters meets a first kinetic parameter threshold for blood brain barrier opening;
and if so, determining that the blood brain barrier of the target object is open.
Further, if the difference value between the first vascular dynamics parameter and the second vascular dynamics parameter does not satisfy the threshold value of the dynamics parameter for opening the blood brain barrier, adjusting the second ultrasonic power, controlling an ultrasonic transmitting device to transmit based on the adjusted second ultrasonic power, controlling a magnetic resonance device to acquire a third magnetic resonance image of the target object, and determining the third vascular dynamics parameter of the target object according to the third magnetic resonance image, wherein the adjusted second ultrasonic power is greater than the second ultrasonic power before adjustment;
determining whether the blood brain barrier of the target object is open according to the third vascular dynamics parameter and the first vascular dynamics parameter; alternatively, the first and second electrodes may be,
and determining whether the blood brain barrier of the target object is open according to the third vascular dynamics parameter and the second vascular dynamics parameter.
Further, the method further comprises:
and when the blood brain barrier of the target object is determined to be opened, performing blood brain barrier opening on the target object according to the second ultrasonic power.
Further, the vasokinetic parameters include a vascular permeability coefficient, a brain flow rate, and a brain blood volume.
In a second aspect, an embodiment of the present invention further provides a blood brain barrier opening monitoring system, including an ultrasound transmitting device, a magnetic resonance device, and a controller; wherein the controller is to:
controlling the ultrasonic emission device to emit based on a first ultrasonic power, controlling the magnetic resonance device to acquire a first magnetic resonance image of a target object, and determining a first blood vessel kinetic parameter of the target object according to the first magnetic resonance image, wherein the first ultrasonic power is less than a standard power for causing blood brain barrier opening;
controlling the ultrasonic emission device to emit based on a second ultrasonic power, controlling the magnetic resonance device to acquire a second magnetic resonance image of the target object, and determining a second vascular dynamics parameter of the target object according to the second magnetic resonance image, wherein the second ultrasonic power is greater than the first ultrasonic power;
determining whether the blood brain barrier of the target object is open according to the first and second vessel dynamics parameters.
Further, the ultrasonic transmitting device is a multi-array element focusing ultrasonic transmitting device compatible with magnetism, and comprises an ultrasonic transmitting array probe.
Furthermore, the ultrasonic emission array probe is provided with scale marks for positioning;
the controller is further configured to position a Z-axis center of the magnetic resonance apparatus at an origin of the graduation marks before the magnetic resonance apparatus is operated.
Further, the magnetic resonance device is also used for positioning the ultrasonic transmitting device and the target object and determining a target region of interest;
the controller is further configured to: and establishing a position mapping relation between the ultrasonic emission array probe and the magnetic resonance device, and determining a combination mode of the ultrasonic emission array probe for ultrasonic emission according to the target region of interest and the position mapping relation.
In a third aspect, an embodiment of the present invention further provides a computer-readable storage medium, on which a computer program is stored, where the computer program, when executed by a processor, implements the method for monitoring blood-brain barrier opening provided in the embodiment of the first aspect of the present invention.
The method comprises the steps of controlling an ultrasonic emission device to emit based on first ultrasonic power, controlling a magnetic resonance device to obtain a first magnetic resonance image of a target object, and determining a first blood vessel kinetic parameter of the target object according to the first magnetic resonance image, wherein the first ultrasonic power is smaller than standard power causing blood brain barrier opening; controlling an ultrasonic emission device to emit based on a second ultrasonic power, controlling a magnetic resonance device to acquire a second magnetic resonance image of the target object, and determining a second vascular dynamics parameter of the target object according to the second magnetic resonance image, wherein the second ultrasonic power is greater than the first ultrasonic power; and determining whether the blood brain barrier of the target object is open according to the first vessel dynamics parameter and the second vessel dynamics parameter. The problems that an imaging probe used in the blood brain barrier opening process in the prior art is high in manufacturing cost and a complex imaging system are solved, so that the blood brain barrier is opened effectively and safely, multi-level global monitoring with high spatial resolution in the blood brain barrier opening process is achieved, and equipment cost is saved.
Drawings
Fig. 1 is a flowchart of a method for monitoring blood-brain barrier opening according to an embodiment of the present invention;
FIG. 2 is a flow chart of a method for monitoring blood-brain barrier opening according to a second embodiment of the present invention;
fig. 3 is a structural diagram of a monitoring system for blood brain barrier opening according to a third embodiment of the present invention;
figure 4 is a schematic diagram of a front view of a chamber of a magnetic resonance imaging apparatus provided by an embodiment of the invention;
fig. 5 is a schematic diagram of a top view and a front view of an ultrasonic transmitting device and a magnetic resonance device fused with space coordinates provided by the embodiment of the invention.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, embodiments of the present invention are described in further detail below with reference to the accompanying drawings. It is to be understood that the specific embodiments described herein are merely illustrative of the invention and are not limiting of the invention.
It should be further noted that, for the convenience of description, only some but not all of the relevant aspects of the present invention are shown in the drawings. Before discussing exemplary embodiments in more detail, it should be noted that some exemplary embodiments are described as processes or methods depicted as flowcharts. Although a flowchart may describe the operations (or steps) as a sequential process, many of the operations can be performed in parallel, concurrently or simultaneously. In addition, the order of the operations may be re-arranged. The process may be terminated when its operations are completed, but may have additional steps not included in the figure. The processes may correspond to methods, functions, procedures, subroutines, and the like.
Example one
Fig. 1 is a flowchart of a method for monitoring blood-brain barrier opening according to an embodiment of the present invention, which is applicable to a situation of opening a blood-brain barrier at a fixed point, safely, effectively, and non-invasively under guidance of a magnetic resonance image, and the method can be performed by a system for monitoring blood-brain barrier opening, and specifically includes the following steps:
s110, controlling an ultrasonic transmitting device to transmit based on first ultrasonic power, controlling a magnetic resonance device to acquire a first magnetic resonance image of a target object, and determining a first blood vessel kinetic parameter of the target object according to the first magnetic resonance image, wherein the first ultrasonic power is smaller than standard power for causing blood brain barrier opening.
Wherein the hemodynamic parameters include a vascular permeability coefficient, a brain flow rate, and a brain blood volume.
Specifically, a first ultrasonic power is selected for emission, and a magnetic resonance sequence in the magnetic resonance device, a rapid magnetic resonance sequence in the image processing module and magnetic resonance contrast agent injection are utilized to complete the acquisition of a first magnetic resonance image of a target object in a short time, the acquisition of the first magnetic resonance image of the target object is completed within, for example, two minutes, after which a first vessel dynamics parameter of the target object is calculated by the controller from the acquired magnetic resonance image, for example, the method for calculating the vascular permeability coefficient according to the first magnetic resonance image by a fitting method according to a pre-established cerebrovascular dynamics model and the magnetic resonance image is the conventional calculation method in the field, the calculation of the vessel dynamics parameters from the magnetic resonance image is prior art, and the specific calculation method will not be described in detail herein.
It should be noted that if no ultrasound effect is selected during the acquisition of the magnetic resonance image, that is, the ultrasound emitting device does not emit the ultrasound power, the magnetic resonance image of the target object is directly acquired by the magnetic resonance device, and the blood vessel kinetic parameters are calculated according to the magnetic resonance image, and at this time, the calculated blood vessel kinetic parameters may be used as the reference parameters. Compared with the prior art in which an ultrasonic image is acquired, the method and the device for acquiring the magnetic resonance image of the target object have the advantages that the requirement on image acquisition equipment is lower, the equipment cost is saved, and meanwhile, the imaging operation is easier.
And S120, controlling the ultrasonic emission device to emit based on a second ultrasonic power, controlling the magnetic resonance device to acquire a second magnetic resonance image of the target object, and determining a second vascular dynamics parameter of the target object according to the second magnetic resonance image, wherein the second ultrasonic power is greater than the first ultrasonic power.
Specifically, the first ultrasonic power is smaller than a standard power causing opening of a blood brain barrier, the second ultrasonic power may be a sum of the first ultrasonic power and a preset power difference, the preset power difference may be set by a person skilled in the art according to experience, a second blood vessel kinetic parameter is obtained by calculation after a second magnetic resonance image acquired on the premise of the second ultrasonic power, if the blood brain barrier is determined to be just opened by the second blood vessel kinetic parameter, the ultrasonic power generation power correction stage is ended, the second ultrasonic power is determined to be ultrasonic power to be subsequently used, if the blood brain barrier is not opened, the second ultrasonic power and the preset power difference are summed on the basis of the second ultrasonic power, and the magnetic resonance image acquired under the ultrasonic power at the moment is re-determined until the ultrasonic power corresponding to the blood brain barrier just opened is determined.
S130, determining whether the blood brain barrier of the target object is open according to the first vessel dynamics parameter and the second vessel dynamics parameter.
Specifically, whether the blood brain barrier of the target object is open or not is judged according to the difference value of the first vessel dynamics parameter and the second vessel dynamics parameter. There are different threshold definitions for blood brain barrier opening depending on the clinical study. Firstly, the blood vessel kinetic parameters calculated by magnetic resonance images acquired without ultrasonic action for the first time are taken as standard blood vessel kinetic parameters, then the blood vessel kinetic parameters calculated by the magnetic resonance images acquired each time are used for solving a difference value with the standard blood vessel kinetic parameters, whether the difference value is larger than a kinetic parameter change threshold value when a blood brain barrier is opened or not is judged, if so, the blood brain barrier is considered to be just opened, and the kinetic parameters calculated after the magnetic resonance images are acquired each time are compared with the standard blood vessel kinetic parameters; and secondly, the magnetic resonance images obtained by adjusting the ultrasonic power of two adjacent times can be compared according to the vascular dynamics parameters obtained by calculating the magnetic resonance images of two adjacent times, and the change of the vascular dynamics parameters obtained by calculating the magnetic resonance images of two consecutive times is judged to be used as the blood brain barrier opening standard.
The magnetic resonance imaging technology has higher time and space resolution and has incomparable advantages in clinical imaging technology. Specifically, the embodiment of the invention calculates the blood vessel dynamics parameters through the magnetic resonance image, and uses the blood vessel dynamics parameters as the judgment basis for the blood brain barrier opening, so that the adoption of an expensive ultrasonic imaging probe with high sensitivity is avoided, the magnetic resonance imaging is easier, the image has higher spatial resolution, the monitoring of the blood brain barrier opening in the whole brain range is facilitated, and the application range is wider.
The technical scheme provided by the embodiment of the invention is used for the ultrasonic emission power calibration stage.
The method comprises the steps of controlling an ultrasonic emission device to emit based on first ultrasonic power, controlling a magnetic resonance device to obtain a first magnetic resonance image of a target object, and determining a first blood vessel kinetic parameter of the target object according to the first magnetic resonance image, wherein the first ultrasonic power is smaller than standard power causing blood brain barrier opening; controlling an ultrasonic emission device to emit based on a second ultrasonic power, controlling a magnetic resonance device to acquire a second magnetic resonance image of the target object, and determining a second vascular dynamics parameter of the target object according to the second magnetic resonance image, wherein the second ultrasonic power is greater than the first ultrasonic power; and determining whether the blood brain barrier of the target object is open according to the first vessel dynamics parameter and the second vessel dynamics parameter. The problems that an imaging probe used in the blood brain barrier opening process in the prior art is high in manufacturing cost and a complex imaging system are solved, the blood brain barrier is effectively and safely opened by utilizing an ultrasonic induction mode, multi-level and high-spatial-resolution global monitoring is carried out on the blood brain barrier opening process, and equipment cost is saved.
Example two
Fig. 2 is a flowchart of a method for monitoring blood-brain barrier opening according to a second embodiment of the present invention. In this embodiment, the step of determining whether the blood brain barrier of the target object is open according to the first hemodynamic parameter and the second hemodynamic parameter is further optimized as follows: determining whether a difference in the first and second hemodynamic parameters meets a first kinetic parameter threshold for blood brain barrier opening; and if so, determining that the blood brain barrier of the target object is open. On this basis, the method further comprises the following steps: and when the blood brain barrier of the target object is determined to be opened, performing blood brain barrier opening on the target object according to the second ultrasonic power.
Correspondingly, the method of the embodiment specifically includes:
s210, controlling an ultrasonic transmitting device to transmit based on first ultrasonic power, controlling a magnetic resonance device to acquire a first magnetic resonance image of a target object, and determining a first blood vessel kinetic parameter of the target object according to the first magnetic resonance image, wherein the first ultrasonic power is less than standard power for causing blood brain barrier opening.
The method comprises the steps that when the ultrasonic transmitting device transmits first ultrasonic power, a magnetic resonance contrast medium is instilled in a target object, and then a magnetic resonance image of the target object is rapidly acquired.
Specifically, the first ultrasonic power is an initial ultrasonic transmission power in an ultrasonic transmission power calibration stage, and on the premise that the first ultrasonic power is smaller than a standard power causing opening of a blood brain barrier, the first ultrasonic power may be zero or an ultrasonic power value randomly selected by a person skilled in the art according to experience, which is not limited in this embodiment of the present invention.
S220, controlling the ultrasonic transmitting device to transmit based on a second ultrasonic power, controlling the magnetic resonance device to acquire a second magnetic resonance image of the target object, and determining a second blood vessel dynamic parameter of the target object according to the second magnetic resonance image, wherein the second ultrasonic power is greater than the first ultrasonic power.
S230, determining whether the difference value of the first vessel dynamic parameter and the second vessel dynamic parameter meets a first dynamic parameter threshold value for blood brain barrier opening; and if so, determining that the blood brain barrier of the target object is open.
If the difference value between the first vascular dynamics parameter and the second vascular dynamics parameter does not meet the threshold value of the dynamics parameter for opening the blood brain barrier, adjusting the second ultrasonic power, controlling an ultrasonic transmitting device to transmit based on the adjusted second ultrasonic power, controlling a magnetic resonance device to acquire a third magnetic resonance image of a target object, and determining the third vascular dynamics parameter of the target object according to the third magnetic resonance image, wherein the adjusted second ultrasonic power is greater than the second ultrasonic power before adjustment;
determining whether the blood brain barrier of the target object is open according to the third vascular dynamics parameter and the first vascular dynamics parameter; or, determining whether the blood brain barrier of the target object is open according to the third vascular dynamics parameter and the second vascular dynamics parameter.
S240, when the blood brain barrier of the target object is determined to be opened, the blood brain barrier of the target object is opened according to the second ultrasonic power.
According to the technical scheme of the embodiment of the invention, the ultrasonic emission power for opening the blood brain barrier of the target object is determined through the magnetic resonance image, the opening degree of the blood brain barrier can be evaluated due to different ultrasonic emission powers, and meanwhile, the vascular dynamics parameters obtained by calculation of the magnetic resonance image have high spatial resolution, so that the monitoring of the blood brain barrier opening in the whole brain range is facilitated.
EXAMPLE III
Fig. 3 is a structural diagram of a blood brain barrier opening monitoring system according to a third embodiment of the present invention, which is applicable to a fixed-point, safe, effective, and noninvasive blood brain barrier opening condition under guidance of a magnetic resonance image.
As shown in fig. 3, the blood-brain barrier opening monitoring system comprises an ultrasonic transmitting device, a magnetic resonance device and a controller; wherein the controller is to:
controlling the ultrasonic emission device to emit based on a first ultrasonic power, controlling the magnetic resonance device to acquire a first magnetic resonance image of a target object, and determining a first blood vessel kinetic parameter of the target object according to the first magnetic resonance image, wherein the first ultrasonic power is less than a standard power for causing blood brain barrier opening;
controlling the ultrasonic emission device to emit based on a second ultrasonic power, controlling the magnetic resonance device to acquire a second magnetic resonance image of the target object, and determining a second vascular dynamics parameter of the target object according to the second magnetic resonance image, wherein the second ultrasonic power is greater than the first ultrasonic power;
determining whether the blood brain barrier of the target object is open according to the first and second vessel dynamics parameters.
The monitoring system for blood brain barrier opening according to the embodiment transmits the data based on the first ultrasonic power by controlling the ultrasonic transmitting device, controls the magnetic resonance device to acquire the first magnetic resonance image of the target object, and determines the first blood vessel kinetic parameter of the target object according to the first magnetic resonance image, wherein the first ultrasonic power is smaller than the standard power for causing the blood brain barrier opening; controlling an ultrasonic emission device to emit based on a second ultrasonic power, controlling a magnetic resonance device to acquire a second magnetic resonance image of the target object, and determining a second vascular dynamics parameter of the target object according to the second magnetic resonance image, wherein the second ultrasonic power is greater than the first ultrasonic power; and determining whether the blood brain barrier of the target object is open according to the first vessel dynamics parameter and the second vessel dynamics parameter. The problems that an imaging probe used in the blood brain barrier opening process in the prior art is high in manufacturing cost and a complex imaging system are solved, so that the blood brain barrier is opened effectively and safely, multi-level global monitoring with high spatial resolution in the blood brain barrier opening process is achieved, and equipment cost is saved.
On the basis of the above embodiments, the ultrasound transmitting device is a magnetically compatible multi-element focused ultrasound transmitting device, and includes an ultrasound transmitting array probe.
On the basis of the above embodiments, the ultrasonic emission array probe has graduation lines for positioning;
the controller is further configured to position a Z-axis center of the magnetic resonance apparatus at an origin of the graduation marks before the magnetic resonance apparatus is operated.
On the basis of the above embodiments, the magnetic resonance apparatus is further configured to locate the ultrasound emitting apparatus and the target object, and determine a target region of interest;
the controller is further configured to: and establishing a position mapping relation between the ultrasonic emission array probe and the magnetic resonance device, and determining a combination mode of the ultrasonic emission array probe for ultrasonic emission according to the target region of interest and the position mapping relation.
Specifically, the controller is connected with the human-computer interaction terminal, and a display interface of the human-computer interaction terminal provides magnetic resonance image display, magnetic resonance scanning parameter editing, ultrasonic emission parameter editing and ultrasonic emission power display. The controller runs a magnetic resonance scanning program, a cerebrovascular dynamics parameter calculation program and an ultrasonic emission planning program. The magnetic resonance device is composed of a magnetic resonance sequence and image processing module, a radio frequency and gradient amplifier, a coil, a magnet and the like, wherein the magnetic resonance sequence and image processing module mainly converts radio frequency digital and gradient digital signals scanned by magnetic resonance into radio frequency intermediate frequency small signals and gradient waveform signals through a digital-to-analog conversion module, and then sends the radio frequency intermediate frequency small signals and the gradient waveform signals to the radio frequency amplifier and the gradient amplifier for amplification so as to push the radio frequency coil and the gradient coil to work for magnetic resonance scanning. The ultrasonic transmitting device mainly completes ultrasonic small signal generation and transmits the small signal to an ultrasonic transmitting array probe link selected by an ultrasonic transmitting planning program, and an ultrasonic electric power monitoring device is arranged in the whole link. In addition, the system also comprises an automatic injection device of the ultrasonic contrast agent required by blood brain barrier opening and a head coil for brain magnetic resonance image acquisition.
The ultrasonic emission array probe device is provided with scale marks for positioning, each array element is distributed on the surface of the spherical surface, and the position of the array element has a fixed space coordinate relative to the far point of the scale mark and is recorded in an ultrasonic planning program. In clinical treatment application, laser of the magnetic resonance device needs to be positioned at a scale origin of the ultrasonic emission array probe, so that the space coordinates of each array element and the space coordinates of the magnetic resonance device can be quickly fused. For example, fig. 4 is a schematic diagram of a front view of a cavity of a magnetic resonance imaging apparatus according to an embodiment of the present invention, fig. 5 is a schematic diagram of a top view and a front view of an ultrasound transmitting apparatus according to an embodiment of the present invention fused with spatial coordinates of the magnetic resonance apparatus, the left view is a top view and the right view is a front view as shown in fig. 5, and in combination with fig. 4 and 5, it can be known that coordinates of a certain array element of the transmitting probe relative to a probe scale are P0(X1, Y1, Z1), and the above positioning manner is combined with a cavity size of the magnetic resonance apparatus, and coordinates of the array element in a physical coordinate system of the magnetic resonance apparatus are P (Xp, Yp, Zp). According to the formula, the method comprises the following steps: xp is X1- (R-H1-H2), wherein R is the radius of the cavity aperture of the magnetic resonance imaging device, H1 is the height of the transmitting probe, and H2 is the height from the plane of the magnetic resonance hospital bed to the arc top at the lower end of the cavity aperture of the magnetic resonance device; y1+ S1, where S1 is the deviation of the laser location line of the magnetic resonance device from the zero scale line of the ultrasound transmission probe on the Y-axis. And when Zp is Z1, establishing a corresponding position mapping relation between the coordinates of the ultrasonic emission probe and the physical coordinates of the magnetic resonance device, so that an ultrasonic emission planning program can be optimized according to a target point appointed on the magnetic resonance image to obtain a relatively ideal emission array element combination for ultrasonic emission.
The application of opening the blood brain barrier by ultrasound to treat brain diseases comprises three stages of preoperative planning, ultrasound emission power calibration and treatment verification. In the preoperative planning stage, the magnetic resonance imaging device can position the ultrasonic emission device and the target object and select a treatment target point of the target object; in the ultrasonic emission power calibration stage, software running on a controller screens unit combinations in an ultrasonic emission device according to a selected target point to perform ultrasonic emission, meanwhile, a blood brain barrier opening auxiliary contrast agent is injected into a target object, a magnetic resonance device is used for performing rapid image acquisition, the software on the controller calculates brain vascular dynamics parameters according to images acquired by magnetic resonance, a vascular dynamics parameter map is used for monitoring the opening condition of an ultrasonic blood brain barrier, the ultrasonic emission power is adjusted, and under the condition of the given auxiliary contrast agent, power parameters which can effectively and safely open the blood brain barrier are found out, so that the aim of effectively opening the blood brain barrier and not causing tissue damage of the target object is fulfilled.
The blood brain barrier opening monitoring system provided by each embodiment can execute the blood brain barrier opening monitoring method provided by any embodiment of the invention, and has corresponding functional modules and beneficial effects for executing the blood brain barrier opening monitoring method.
Example four
An embodiment of the present invention further provides a computer-readable storage medium, on which a computer program is stored, where the computer program, when executed by a processor, implements a method for monitoring blood-brain barrier opening, where the method includes:
controlling an ultrasonic emission device to emit based on first ultrasonic power, controlling a magnetic resonance device to acquire a first magnetic resonance image of a target object, and determining a first blood vessel kinetic parameter of the target object according to the first magnetic resonance image, wherein the first ultrasonic power is less than standard power for causing blood brain barrier opening;
controlling the ultrasonic emission device to emit based on a second ultrasonic power, controlling the magnetic resonance device to acquire a second magnetic resonance image of a target object, and determining a second vascular dynamics parameter of the target object according to the second magnetic resonance image, wherein the second ultrasonic power is greater than the first ultrasonic power;
determining whether the blood brain barrier of the target object is open according to the first and second vessel dynamics parameters.
Of course, the computer-readable storage medium provided by the embodiments of the present invention, on which the computer program is stored, is not limited to the method operations described above, and may also perform related operations in the method for monitoring blood-brain barrier opening provided by any embodiment of the present invention.
Computer storage media for embodiments of the invention may employ any combination of one or more computer-readable media. The computer readable medium may be a computer readable signal medium or a computer readable storage medium. A computer readable storage medium may be, for example, but not limited to, an electronic, magnetic, optical, electromagnetic, infrared, or semiconductor system, apparatus, or device, or any combination of the foregoing. More specific examples (a non-exhaustive list) of the computer readable storage medium would include the following: an electrical connection having one or more wires, a portable computer diskette, a hard disk, a Random Access Memory (RAM), a read-only memory (ROM), an erasable programmable read-only memory (EPROM or flash memory), an optical fiber, a portable compact disc read-only memory (CD-ROM), an optical storage device, a magnetic storage device, or any suitable combination of the foregoing. In the context of this document, a computer readable storage medium may be any tangible medium that can contain, or store a program for use by or in connection with an instruction execution system, apparatus, or device.
A computer readable signal medium may include a propagated data signal with computer readable program code embodied therein, for example, in baseband or as part of a carrier wave. Such a propagated data signal may take many forms, including, but not limited to, electro-magnetic, optical, or any suitable combination thereof. A computer readable signal medium may also be any computer readable medium that is not a computer readable storage medium and that can communicate, propagate, or transport a program for use by or in connection with an instruction execution system, apparatus, or device.
Program code embodied on a computer readable medium may be transmitted using any appropriate medium, including but not limited to wireless, wireline, optical fiber cable, RF, etc., or any suitable combination of the foregoing.
Computer program code for carrying out operations for aspects of the present invention may be written in any combination of one or more programming languages, including an object oriented programming language such as Java, Smalltalk, C + + or the like and conventional procedural programming languages, such as the "C" programming language or similar programming languages. The program code may execute entirely on the user's computer, partly on the user's computer, as a stand-alone software package, partly on the user's computer and partly on a remote computer or entirely on the remote computer or server. In the case of a remote computer, the remote computer may be connected to the user's computer through any type of network, including a Local Area Network (LAN) or a Wide Area Network (WAN), or the connection may be made to an external computer (for example, through the Internet using an Internet service provider).
It is to be noted that the foregoing is only illustrative of the preferred embodiments of the present invention and the technical principles employed. It will be understood by those skilled in the art that the present invention is not limited to the particular embodiments described herein, but is capable of various obvious changes, rearrangements and substitutions as will now become apparent to those skilled in the art without departing from the scope of the invention. Therefore, although the present invention has been described in greater detail by the above embodiments, the present invention is not limited to the above embodiments, and may include other equivalent embodiments without departing from the spirit of the present invention, and the scope of the present invention is determined by the scope of the appended claims.
Claims (8)
1. A monitoring method for blood brain barrier opening is used in an ultrasonic emission power calibration stage and is characterized by comprising the following steps:
controlling an ultrasonic emission device to emit based on first ultrasonic power, controlling a magnetic resonance device to acquire a first magnetic resonance image of a target object, and determining a first blood vessel kinetic parameter of the target object according to the first magnetic resonance image, wherein the first ultrasonic power is less than standard power for causing blood brain barrier opening;
controlling the ultrasonic emission device to emit based on a second ultrasonic power, controlling the magnetic resonance device to acquire a second magnetic resonance image of a target object, and determining a second vascular dynamics parameter of the target object according to the second magnetic resonance image, wherein the second ultrasonic power is greater than the first ultrasonic power;
determining whether the blood brain barrier of the target object is open according to the first and second vessel dynamics parameters.
2. The method of claim 1, wherein determining whether the blood-brain barrier of the target subject is open based on the first and second hemodynamic parameters comprises:
determining whether a difference in the first and second hemodynamic parameters meets a first kinetic parameter threshold for blood brain barrier opening;
and if so, determining that the blood brain barrier of the target object is open.
3. The method according to claim 2, wherein if the difference between the first vascular dynamics parameter and the second vascular dynamics parameter does not satisfy the threshold of the dynamics parameter for opening the blood-brain barrier, the second ultrasound power is adjusted, the ultrasound emitting device is controlled to emit based on the adjusted second ultrasound power, the magnetic resonance device is controlled to acquire a third magnetic resonance image of the target object, and the third vascular dynamics parameter of the target object is determined according to the third magnetic resonance image, wherein the adjusted second ultrasound power is greater than the second ultrasound power before adjustment;
determining whether the blood brain barrier of the target object is open according to the third vascular dynamics parameter and the first vascular dynamics parameter; alternatively, the first and second electrodes may be,
and determining whether the blood brain barrier of the target object is open according to the third vascular dynamics parameter and the second vascular dynamics parameter.
4. The method of claim 1, further comprising:
and when the blood brain barrier of the target object is determined to be opened, performing blood brain barrier opening on the target object according to the second ultrasonic power.
5. The method of claim 1, wherein the hemodynamic parameters include a vascular permeability coefficient, a brain flow rate, and a brain blood volume.
6. A monitoring system for blood brain barrier opening is characterized by comprising an ultrasonic transmitting device, a magnetic resonance device and a controller; wherein the controller is to:
controlling the ultrasonic emission device to emit based on a first ultrasonic power, controlling the magnetic resonance device to acquire a first magnetic resonance image of a target object, and determining a first blood vessel kinetic parameter of the target object according to the first magnetic resonance image, wherein the first ultrasonic power is less than a standard power for causing blood brain barrier opening;
controlling the ultrasonic emission device to emit based on a second ultrasonic power, controlling the magnetic resonance device to acquire a second magnetic resonance image of the target object, and determining a second vascular dynamics parameter of the target object according to the second magnetic resonance image, wherein the second ultrasonic power is greater than the first ultrasonic power;
determining whether the blood brain barrier of the target object is open according to the first and second vascular dynamics parameters;
the ultrasonic transmitting device is a magnetic compatible multi-array element focusing ultrasonic transmitting device and comprises an ultrasonic transmitting array probe;
the ultrasonic emission array probe is provided with scale marks for positioning;
the controller is further configured to position a Z-axis center of the magnetic resonance apparatus at an origin of the graduation marks before the magnetic resonance apparatus operates, and the coordinates of the ultrasound emission array probe and the physical coordinates of the magnetic resonance apparatus establish a corresponding position mapping relationship.
7. The system for monitoring blood brain barrier opening according to claim 6, wherein said magnetic resonance device is further configured to locate said ultrasound emitting device and said target object, determining a target region of interest;
the controller is further configured to: and establishing a position mapping relation between the ultrasonic emission array probe and the magnetic resonance device, and determining a combination mode of the ultrasonic emission array probe for ultrasonic emission according to the target region of interest and the position mapping relation.
8. A computer-readable storage medium, on which a computer program is stored which, when being executed by a processor, carries out the method for monitoring blood-brain barrier opening according to any one of claims 1 to 5.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910515414.0A CN110215601B (en) | 2019-06-14 | 2019-06-14 | Blood brain barrier opening monitoring method, system and storage medium |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910515414.0A CN110215601B (en) | 2019-06-14 | 2019-06-14 | Blood brain barrier opening monitoring method, system and storage medium |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN110215601A CN110215601A (en) | 2019-09-10 |
| CN110215601B true CN110215601B (en) | 2021-08-31 |
Family
ID=67817131
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910515414.0A Active CN110215601B (en) | 2019-06-14 | 2019-06-14 | Blood brain barrier opening monitoring method, system and storage medium |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN110215601B (en) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102791332A (en) * | 2009-11-04 | 2012-11-21 | 代理并代表亚利桑那州立大学的亚利桑那董事会 | Devices and methods for modulating brain activity |
| CN107753062A (en) * | 2017-11-27 | 2018-03-06 | 西安交通大学 | TCD,transcranial Doppler cerebral angiography super-resolution imaging method based on Markov chain Monte-Carlo multi-target tracking |
| CN109688934A (en) * | 2016-08-01 | 2019-04-26 | 戈尔丹斯医疗公司 | The opening of the blood-brain barrier of ultrasonic guidance |
-
2019
- 2019-06-14 CN CN201910515414.0A patent/CN110215601B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102791332A (en) * | 2009-11-04 | 2012-11-21 | 代理并代表亚利桑那州立大学的亚利桑那董事会 | Devices and methods for modulating brain activity |
| CN109688934A (en) * | 2016-08-01 | 2019-04-26 | 戈尔丹斯医疗公司 | The opening of the blood-brain barrier of ultrasonic guidance |
| CN107753062A (en) * | 2017-11-27 | 2018-03-06 | 西安交通大学 | TCD,transcranial Doppler cerebral angiography super-resolution imaging method based on Markov chain Monte-Carlo multi-target tracking |
Non-Patent Citations (1)
| Title |
|---|
| CT灌注成像评估超声开放血脑屏障的初步研究;陈路锋;《万方数据》;20120903;第1页，"中文论著摘要"；第21-25页，"四病理结果" * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN110215601A (en) | 2019-09-10 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US20230005598A1 (en) | Head modeling for a therapeutic or diagnostic procedure | |
| JP6832958B2 (en) | Patient-specific headsets for diagnostic and therapeutic transcranial procedures | |
| US10376171B2 (en) | Method and device for determining and presenting surface charge and dipole densities on cardiac walls | |
| EP2726152B1 (en) | System for controlling focused ultrasound treatment | |
| US6792074B2 (en) | Method for producing or updating radiotherapy plan | |
| US20100268072A1 (en) | Method and apparatus for positional tracking of therapeutic ultrasound transducer | |
| CN104000588A (en) | Method and system for positioning patient in medical device | |
| JP2012517262A (en) | Method and system for tracking and mapping in medical procedures | |
| CN104936517A (en) | Transducers, systems, and manufacturing techniques for focused ultrasound therapies | |
| JP2010503439A (en) | Method and apparatus for correcting errors in the mutual display of a coordinate system used to display an object presented during navigation brain stimulation | |
| WO2006089112A3 (en) | Systems and methods for planning medical procedures and designing medical devices based on anatomical scan deformations | |
| CN103733083A (en) | Reducing the radio-frequency transmit field in a predetermined volume during magnetic resonance imaging | |
| US20220288424A1 (en) | Aberration corrections for dynamically changing media during ultrasound therapy | |
| CN105828722A (en) | Electromagnetic tracker based ultrasound probe calibration | |
| KR20190030698A (en) | Motor-assisted needle guide assembly for ultrasonic needle placement | |
| JP2011083609A (en) | Medical system, operation method thereof, and active implant medical device | |
| Mougenot et al. | High intensity focused ultrasound with large aperture transducers: a MRI based focal point correction for tissue heterogeneity | |
| CN110559564A (en) | ultrasonic stimulation method and device | |
| CN107783066B (en) | Medical imaging system and positioning method thereof | |
| CN111870344A (en) | Preoperative navigation method, system and terminal equipment | |
| CN110215601B (en) | Blood brain barrier opening monitoring method, system and storage medium | |
| CN114733073A (en) | Transcranial magnetic stimulation method and system based on electromagnetic navigation positioning and electronic equipment | |
| Unger et al. | Robot-assisted ultrasound-guided tracking of anatomical structures for the application of focused ultrasound | |
| US20130136329A1 (en) | Method and system for automatically setting a landmark for brain scans | |
| CN112842531B (en) | Neurosurgery operation planning system |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |