CN110211654A - A kind of the caryogram detection system and method for automatic hiding gender information - Google Patents
A kind of the caryogram detection system and method for automatic hiding gender information Download PDFInfo
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- 238000001514 detection method Methods 0.000 title claims abstract description 29
- 238000000034 method Methods 0.000 title abstract description 9
- 210000003765 sex chromosome Anatomy 0.000 claims abstract description 42
- 210000000349 chromosome Anatomy 0.000 claims abstract description 24
- 230000001575 pathological effect Effects 0.000 claims abstract description 18
- 230000007170 pathology Effects 0.000 claims abstract description 12
- 210000003754 fetus Anatomy 0.000 claims abstract description 5
- 238000012550 audit Methods 0.000 claims description 12
- 239000008280 blood Substances 0.000 claims description 9
- 210000004369 blood Anatomy 0.000 claims description 9
- 238000004458 analytical method Methods 0.000 claims description 8
- 238000004321 preservation Methods 0.000 claims description 7
- 238000010241 blood sampling Methods 0.000 claims description 6
- 238000007639 printing Methods 0.000 claims description 6
- 238000012795 verification Methods 0.000 claims description 2
- 238000004043 dyeing Methods 0.000 claims 1
- 238000005070 sampling Methods 0.000 claims 1
- 238000005516 engineering process Methods 0.000 abstract description 8
- 230000000694 effects Effects 0.000 abstract description 4
- 208000028782 Hereditary disease Diseases 0.000 abstract description 3
- 208000026350 Inborn Genetic disease Diseases 0.000 abstract description 3
- 208000024556 Mendelian disease Diseases 0.000 abstract description 3
- 238000011065 in-situ storage Methods 0.000 abstract description 3
- 201000010099 disease Diseases 0.000 description 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 6
- 238000003745 diagnosis Methods 0.000 description 5
- 210000001726 chromosome structure Anatomy 0.000 description 2
- 238000012217 deletion Methods 0.000 description 2
- 230000037430 deletion Effects 0.000 description 2
- 239000012634 fragment Substances 0.000 description 2
- 230000002068 genetic effect Effects 0.000 description 2
- 230000035935 pregnancy Effects 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 230000001568 sexual effect Effects 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 208000008899 Habitual abortion Diseases 0.000 description 1
- 208000027399 Sex Chromosome disease Diseases 0.000 description 1
- 230000005856 abnormality Effects 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 230000002759 chromosomal effect Effects 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 230000002559 cytogenic effect Effects 0.000 description 1
- 238000007405 data analysis Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 230000005611 electricity Effects 0.000 description 1
- 210000002415 kinetochore Anatomy 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000031864 metaphase Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000005945 translocation Effects 0.000 description 1
- 230000017105 transposition Effects 0.000 description 1
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- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H15/00—ICT specially adapted for medical reports, e.g. generation or transmission thereof
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- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
- G16H50/20—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
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Abstract
The invention discloses the caryogram detection systems and method of a kind of automatic hiding gender information, include the following steps: the karyotyping that chromosome is carried out using intelligence system, when sex chromosome is without hereditary pathological characters, electronic diagnostics report that intelligence system generates or the picture and mark that sex chromosome is deleted in formal report；Intelligence system generates if sex chromosome has hereditary pathological characters electronic diagnostics report and the picture and pathology mark for retaining sex chromosome in formal report.The present invention is in the hereditary disease detection for carrying out fetus, it is therefore prevented that its illegal activities for carrying out sex identification, it is therefore prevented that the abuse of technology, and make full use of the detection device of core area and strength to realize patient from far-off regions and be carried out in situ detection.
Description
Technical field
This patent belongs to medical field more particularly to a kind of the caryogram detection system and method for automatic hiding gender information.
Background technique
Although genetic fragment detection technique, in rapid development, current genetic fragment detection technique can only detect 13/18/
No. 21 autosomes and sex chromosome number can not analyse whether the chromosome structures sexual abnormality such as transposition, repetition, and can not diagnose
Chimera is especially for variation medical diagnosis on disease on chromosome such as habitual abortion caused by chromosome translocation etc..Therefore
In the hereditary information such as biological stain body times body and medical diagnosis on disease field, chromosome karyotype analysis technology still has irreplaceable
Property.
Most of diseases based on chromosomal variation, chromosome karyotype analysis technology Relative gene segment technology have simultaneously
Low cost and broad-spectrum sexual clorminance.And the accumulation of extensive chromosome karyotype analysis technology detection data, it can low cost, more comprehensively
Preservation hereditary information feature and can identify, count, standardized long-term large sample record, be hereditary information (chromosome
Picture sample) it carries out big data analysis with being related for disease and provides guaranteed reliability.
Chromosome karyotype analysis is using metaphase chromosome as research object, according to the length of chromosome, kinetochore position
It sets, the features such as the presence or absence of long galianconism ratio, satellite, and chromosome is analyzed, compare, sort and is compiled by banding technique
Number, situation is made a variation according to chromosome structure sum number purpose to be tested and analyzed.Karyotyping can be cytogenetics classification, object
The relationship and chromosome number of inter-species relationship and the research of structure variation provide important evidence.
Since the caryogram detection of chromosome can judge all kinds of dominant and recessive hereditary disease very early,
Increasingly become the detection means that people carry out pregnancy period especially early pregnancy.But due to the gender in chromosome karyotype analysis
Chromosome has reflected the gender of infant, causes this technology that may be abused, and causes to carry out antenatal fetus identification
Illegal activities.
Summary of the invention
To solve the above problems, the invention discloses the caryogram detection systems and method of a kind of automatic hiding gender information.
The present invention is in the hereditary disease detection for carrying out fetus, it is therefore prevented that its illegal activities for carrying out sex identification, it is therefore prevented that technology
Abuse, and make full use of the detection device of core area and strength to realize patient from far-off regions and be carried out in situ detection.
To achieve the above object, the technical solution of the present invention is as follows:
A kind of caryogram detection method of automatic hiding gender information, includes the following steps: to be dyed using intelligence system
The karyotyping of body, when the electronic diagnostics report or formal report that sex chromosome is without hereditary pathological characters, and intelligence system generates
The middle picture and mark for deleting sex chromosome；The electronics that intelligence system generates if sex chromosome has hereditary pathological characters
Retain the picture and pathology mark of sex chromosome in diagnosis report and formal report.
Further to improve, the sex chromosome is the sex chromosome of fetus.
It is further to improve, include the following steps:
Step 1: patient passes through sample point blood sampling, preservation, coding, typing information and labelled；
Step 2: sending label blood sample to film-making center；
Step 3: film-making centronucleus to after blood sample information carry out film-making, take pictures, then by client submission；
Step 4: client is sent to intelligence system by network；
Step 5: intelligence system is checked and marked with case to chromosome number and karyotyping result, and generate
Then karyotyping legend generates electronic diagnostics report, examine Step 6: electronic diagnostics report is sent to expert and audits end
Core, printing, stamped signature generate formal report；
Step 7: formal report is sent to sampling center and user；Wherein, special without hereditary pathology as sex chromosome
It levies, the picture and mark of sex chromosome is deleted in the electronic diagnostics report of intelligence system generation or formal report；As gender contaminates
There is the electronic diagnostics report that then intelligence system generates of hereditary pathological characters and retain sex chromosome's in formal report in colour solid
Picture and pathology mark.
A kind of caryogram detection system of automatic hiding gender information, including to chromosome number and karyotyping result and disease
Example is checked and is marked, and the intelligence system selected karyotyping legend, generate electronic diagnostics report, and intelligence system includes protecting
Close unit, if sex chromosome is without hereditary pathological characters, secret unit deletion property in electronic diagnostics report or formal report
The picture and mark of other chromosome；Secret unit is reported and just in electronic diagnostics if sex chromosome has hereditary pathological characters
Retain the picture and pathology mark of sex chromosome in formula report.
It is further to improve, it further include sample point, film-making center, client and expert audit end；The sample point is used for
To patient's blood sampling, preservation, coding, typing information and labelled；The film-making center for acquirement blood sample carry out film-making,
It takes pictures, the photo taken pictures then is transferred to by intelligence system by client；Expert audits end and reports progress people to electronic diagnostics
Work audit, then intelligence system printing stamped signature generates formal report, then formal report is sent to sampling center and user.
Advantages of the present invention:
1. realizing patient from far-off regions is carried out in situ detection；
2. making full use of the detection device and strength of core area；
3. improving diagnostic analysis efficiency and accuracy by remote computing system；
4. solving the ineffective labor in artificial read tablet to low-quality picture, professional's working strength is reduced, is promoted
Detection level；
5. finding picture quality problem in time in long-range treatment process, solving in time, improve and link up accuracy and effect
Rate prevents false diagnosis caused by delaying because of communication and material from losing damage；
6. a pair non-sex chromosome disease detection result is hidden.
Detailed description of the invention
Fig. 1 is karyotyping flow diagram.
Specific embodiment
The present invention will be further described with reference to the accompanying drawings and embodiments.
Embodiment
A kind of caryogram detection system of automatic hiding gender information, including to chromosome number and karyotyping result and disease
Example is checked and is marked, and the intelligence system selected karyotyping legend, generate electronic diagnostics report, and intelligence system includes protecting
Close unit, if sex chromosome is without hereditary pathological characters, secret unit deletion property in electronic diagnostics report or formal report
The picture and mark of other chromosome；Secret unit is reported and just in electronic diagnostics if sex chromosome has hereditary pathological characters
Retain the picture and pathology mark of sex chromosome in formula report.It further include sample point, film-making center, client and expert audit
End；The sample point is used for patient's blood sampling, preservation, coding, typing information and labelled；The film-making center is for taking
The blood sample obtained carries out film-making, takes pictures, and the photo taken pictures then is transferred to intelligence system by client；Expert audits end to electricity
Sub- diagnosis report carries out manual examination and verification, and then intelligence system printing stamped signature generates formal report, then formal report is sent to and is taken
Sample center and user.
It includes secret unit that expert, which audits end, if sex chromosome, without hereditary pathological characters, secret unit is formally being reported
The picture and mark of sex chromosome are deleted in announcement；Secret unit is formally being reported if sex chromosome has hereditary pathological characters
Retain the picture and pathology mark of sex chromosome in announcement.
The application method of above-mentioned long-range karyotype detection system, includes the following steps:
Step 1: patient passes through sample point blood sampling, preservation, coding, typing information and labelled；
Step 2: sending label blood sample to film-making center；
Step 3: film-making centronucleus to after blood sample information carry out film-making, take pictures, then by client submission；
Step 4: client is sent to intelligence system by network；
Step 5: intelligence system is checked and marked with case to chromosome number and karyotyping result, and generate
Then karyotyping legend generates electronic diagnostics report, examine Step 6: electronic diagnostics report is sent to expert and audits end
Core, printing, stamped signature generate formal report；
Step 7: formal report is sent to sampling center and user；Wherein, special without hereditary pathology as sex chromosome
It levies, the picture and mark of sex chromosome is deleted in the electronic diagnostics report of intelligence system generation or formal report；As gender contaminates
There is the electronic diagnostics report that then intelligence system generates of hereditary pathological characters and retain sex chromosome's in formal report in colour solid
Picture and pathology mark.
Wherein can according to the grade of doctor, to it is more than a certain grade doctor or with the farther away doctor of patient's region distance
The electronic diagnostics with sex chromosome are sent to report, and to below a certain grade or apart from the closer doctor of patient send without
There are the electronic diagnostics of sex chromosome to report, thus abuse of the control to technology.
Although the embodiments of the present invention have been disclosed as above, but it is not restricted to listed fortune in specification and embodiment
With it can be fully applied to various fields suitable for the present invention, for those skilled in the art, can be easily real
Now other modification, therefore without departing from the general concept defined in the claims and the equivalent scope, the present invention is not limited to
Specific details and the legend herein shown with description.
Claims (5)
1. a kind of caryogram detection method of automatic hiding gender information, which comprises the steps of: use intelligence system
The karyotyping for carrying out chromosome, when sex chromosome is without hereditary pathological characters, electronic diagnostics report that intelligence system generates or
The picture and mark of sex chromosome are deleted in formal report；Intelligence system is raw if sex chromosome has hereditary pathological characters
At electronic diagnostics report and formal report in retain sex chromosome picture and pathology mark.
2. the caryogram detection method of automatic hiding gender information as described in claim 1, which is characterized in that the gender dyeing
Body is the sex chromosome of fetus.
3. the caryogram detection method of automatic hiding gender information as described in claim 1, which is characterized in that including walking as follows
It is rapid:
Step 1: patient passes through sample point blood sampling, preservation, coding, typing information and labelled；
Step 2: sending label blood sample to film-making center；
Step 3: film-making centronucleus to after blood sample information carry out film-making, take pictures, then by client submission；
Step 4: client is sent to intelligence system by network；
Step 5: intelligence system is checked and marked with case to chromosome number and karyotyping result, and generate caryogram
Analyze legend, then generate electronic diagnostics report, Step 6: by electronic diagnostics report be sent to expert audit end audit,
Printing, stamped signature generate formal report；
Step 7: formal report is sent to sampling center and user；Wherein, when sex chromosome is without hereditary pathological characters, intelligence
The picture and mark of sex chromosome are deleted in the electronic diagnostics report of energy system generation or formal report；As sex chromosome deposits
Hereditary pathological characters then intelligence system generate electronic diagnostics report and formal report in retain sex chromosome picture and
Pathology mark.
4. a kind of caryogram detection system of automatic hiding gender information, which is characterized in that including to chromosome number and caryogram point
The intelligence system that analysis result is checked and marked with case, and selected karyotyping legend, generates electronic diagnostics report, intelligence
System includes secret unit, if sex chromosome, without hereditary pathological characters, secret unit is reported in electronic diagnostics or formally reported
The picture and mark of sex chromosome are deleted in announcement；Secret unit is examined in electronics if sex chromosome has hereditary pathological characters
Retain the picture and pathology mark of sex chromosome in disconnected report and formal report.
5. the caryogram detection system of automatic hiding gender information as claimed in claim 4, which is characterized in that further include sampling
Point, film-making center, client and expert audit end；The sample point is used for patient's blood sampling, preservation, coding, typing information
And it is labelled；The film-making center carries out film-making for the blood sample of acquirement, takes pictures, the photo that then will be taken pictures by client
It is transferred to intelligence system；Expert audits end and reports progress manual examination and verification to electronic diagnostics, and then intelligence system printing stamped signature generates
Formal report, then formal report is sent to sampling center and user.
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| CN201910466077.0A CN110211654A (en) | 2019-05-30 | 2019-05-30 | A kind of the caryogram detection system and method for automatic hiding gender information |
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| CN201910466077.0A CN110211654A (en) | 2019-05-30 | 2019-05-30 | A kind of the caryogram detection system and method for automatic hiding gender information |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050049793A1 (en) * | 2001-04-30 | 2005-03-03 | Patrizia Paterlini-Brechot | Prenatal diagnosis method on isolated foetal cell of maternal blood |
| CN103403183A (en) * | 2011-06-29 | 2013-11-20 | 深圳华大基因健康科技有限公司 | Noninvasive detection of fetal genetic abnormality |
| CN103525939A (en) * | 2013-10-28 | 2014-01-22 | 广州爱健生物技术有限公司 | Method and system for noninvasive detection of fetus chromosome aneuploid |
| JP2016066219A (en) * | 2014-09-24 | 2016-04-28 | 富士フイルム株式会社 | Inspection notification provision device, inspection notification provision method, inspection notification provision program, and chromosome inspection system |
| CN107133495A (en) * | 2017-05-04 | 2017-09-05 | 北京医院 | A kind of analysis method and analysis system of aneuploidy biological information |
| CN107949845A (en) * | 2015-08-06 | 2018-04-20 | 伊万基因诊断中心有限公司 | The new method of sex of foetus and fetus sex chromosomal abnormality can be distinguished on multiple platforms |
| CN108186053A (en) * | 2018-01-15 | 2018-06-22 | 中国人民解放军第四军医大学 | A kind of fetus panorama based on ultrasound and 3D technology shows instrument |
| CN108396058A (en) * | 2018-01-19 | 2018-08-14 | 刘晓雯 | Detect the methods for prenatal diagnosis of chromosome abnormality |
| CN108611408A (en) * | 2018-02-23 | 2018-10-02 | 深圳市瀚海基因生物科技有限公司 | The method and apparatus for detecting fetal chromosomal aneuploidy |
-
2019
- 2019-05-30 CN CN201910466077.0A patent/CN110211654A/en active Pending
Patent Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050049793A1 (en) * | 2001-04-30 | 2005-03-03 | Patrizia Paterlini-Brechot | Prenatal diagnosis method on isolated foetal cell of maternal blood |
| CN103403183A (en) * | 2011-06-29 | 2013-11-20 | 深圳华大基因健康科技有限公司 | Noninvasive detection of fetal genetic abnormality |
| CN103525939A (en) * | 2013-10-28 | 2014-01-22 | 广州爱健生物技术有限公司 | Method and system for noninvasive detection of fetus chromosome aneuploid |
| JP2016066219A (en) * | 2014-09-24 | 2016-04-28 | 富士フイルム株式会社 | Inspection notification provision device, inspection notification provision method, inspection notification provision program, and chromosome inspection system |
| CN107949845A (en) * | 2015-08-06 | 2018-04-20 | 伊万基因诊断中心有限公司 | The new method of sex of foetus and fetus sex chromosomal abnormality can be distinguished on multiple platforms |
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| CN108186053A (en) * | 2018-01-15 | 2018-06-22 | 中国人民解放军第四军医大学 | A kind of fetus panorama based on ultrasound and 3D technology shows instrument |
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Application publication date: 20190906 |