CN110201013A - A kind of application of radix saposhnikoviae essential oil - Google Patents
A kind of application of radix saposhnikoviae essential oil Download PDFInfo
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Abstract
The invention discloses a kind of application of windproof essential oil, windproof essential oil can be used for preparing the drug for treating or preventing brain function and its disorder disease, the health-oriented products for improving brain function and its disorder disease.Present invention firstly discovers that windproof essential oil shows active medicine or big health-oriented products new application in experimental animal brain function and its disorder disease；Windproof essential oil is found for the first time or containing the symptom that can improve the brain functions such as senile dementia, depressive anxiety and its obstacle animal in windproof essential oil or its arbitrary composition in animal body model.Compared with the drug for the treatment of brain function and its obstacle at present, windproof essential oil or any combination thereof object has the mechanism that the polymoleculars such as neurotransmitter act synergistically on multiple target point that adjusts, and have good medicine for parameter, it is easy to through blood-brain barrier, therefore there is the characteristics of toxicological safety, metabolic stability, longer half-life period, lesser side effect.
Description
Technical field
The present invention relates to biomedicine technical field, especially a kind of windproof essential oil preparation treat and prevent brain function and
Application in its disorder disease drug and health-oriented products.
Background technique
Umbelliferae Saposhnikovia divaricata (Saposhnikovia divaricata (Turcz.) Schischk.), it is main at present to plant
It trains in Heilungkiang, the Inner Mongol, Hebei and other places.The dry root of radix saposhnikoviae is Chinese medicine traditional simply, and history tree is included,
First recorded in Shennong's Herbal, it is classified as careless portion's top grade.Radix saposhnikoviae has the effect of expelling pathogenic wind from the body surface, expel endogenous wind to relieve convulsion, relieving convulsion.It is usually used in
Cold headache is treated, rheumatic arthralgia , Feng Shen itch is broken to put the diseases such as wind in order.It is anti-to mainly contain volatile oil, chromogen ketone, Coumarins
Equal ingredients, volatile oil are considered as one of main active constituent of radix saposhnikoviae.Modern pharmacology research shows that windproof essential oil has
Antipyretic-antalgic, it is antibacterial, anti-inflammatory, hemostasis, it is calm, anti-oxidant, raising immunity of organisms the effects of.Main mechanism is related to improving pain
Threshold, the phagocytic activity removed free radical, improve macrophage, the killing activity for improving NK cell, reduction plasmin activity etc..
In recent years, having document to be related to radix saposhnikoviae has calmness and extends preclinical effect of fainting from fear, it is believed that chromone, cumarin, poly- second
The result of a variety of chemical component synergistic effects such as alkynes, volatile oil.
So far, have several patents and be related to the medical usage of windproof essential oil or compound ledebouriella root essential oil, there is anti-bacterial, anti-itching, mention
The effects of high body immunity, treatment children's fash, cerebral ischemia, the infection of the upper respiratory tract.Currently, patent there is no to be related to windproof essence
Alleviation or therapeutic effect of the oil to brain function and its disorder disease.
Fragrant medicinal plant plays an important role in the treatment or alleviation of brain function and its disorder disease.In the recent period, I
Application cholinesterase activity rating model and compound induce senile dementia zebra fish body in screening model research radix saposhnikoviae
When essential oil improves CNS disease, find for the first time, Umbelliferae radix saposhnikoviae platymiscium radix saposhnikoviae (Saposhnikovia divaricata
(Turcz.) Schischk.) essential oil can significantly improve the cognition and respond of senile dementia zebra fish.Windproof essential oil
Brain function and its obstacle can be effectively adjusted, can be used for treatment/prevention or alleviate to include anxiety, depression, insomnia, neurological
Brain functions and its disorder diseases such as property disease.Before, this pharmacological action is not yet reported.
Summary of the invention
In view of the above-mentioned deficiencies in the prior art, it is an object of the present invention to provide a kind of application of windproof essential oil.
The purpose of the present invention is achieved through the following technical solutions: a kind of application of radix saposhnikoviae essential oil, the application packet
Include application of the windproof essential oil in the drug that preparation treats or prevents brain function and its disorder disease, windproof essential oil changes in preparation
Application in the health-oriented products of kind brain function and its disorder disease.
Further, the windproof essential oil is prepared by the following method to obtain:
(1) it ferments: choosing dry windproof rhizome, pile fermentation is placed 1-2 days, and the coarse granule for being then crushed to 30-60 mesh is standby
With.
(2) extract: the coarse granule that step 1 is obtained is soaked in the hydrochloric acid or sulfuric acid that the pH value of 7-9 times of quality is 5.0-6.0
In aqueous solution, extraction overnight, obtains extraction mixed liquor.
(3) it digests: cellulase and pectase, cellulase, pectase being added into the extraction mixed liquor that step 2 obtains
With extraction mixed liquor quality proportioning be 0.5-1:0.1-0.5:100,35-37 DEG C enzymatic hydrolysis 2-3 hours.
(4) it extracts, including following two method:
(4.1) mixed liquor after step 3 enzymatic hydrolysis is put into steam distillation to extract in instrument, 100 DEG C of -120 DEG C of reflux mention
It takes 5-7 hour, collects distillate, be cooled to room temperature to be placed in oil water separator and separate, oil reservoir is dry with anhydrous sodium sulfate
Dry, separation is to get windproof essential oil；
(4.2) mixed liquor after step 3 enzymatic hydrolysis is put into CO 2 supercritical to extract in instrument, the temperature of extraction is
45 DEG C -48 DEG C, pressure 13.70MPa-17.80MPa, time 50min-100min, the flow velocity of carbon dioxide is 25kg/h-
35kg/h；Essential oil is collected, is placed in molecular distillation instrument and refines, feeding temperature is 40 DEG C -45 DEG C, and sample introduction speed is 480-
530mL/h, one section of evaporating temperature are 110 DEG C -115 DEG C, and dual circulation temperature is 60 DEG C -65 DEG C, collect two sections of distillation fractions,
Up to windproof essential oil.
Further, the radix saposhnikoviae is Umbelliferae radix saposhnikoviae platymiscium radix saposhnikoviae.
Further, the windproof essential oil gas chromatography-mass spectrometry analysis detection, by mass percentage, group
Divide ratio are as follows: camphor > 14%, 3- carene > 5%, D- limonene > 5%, Bronyl acetate > 4%, β-bisabolene > 4%,
(+)-sickleleaf celery alcohol > 3%.
Further, the brain function and its disorder disease include anxiety, depression, insomnia, epilepsy, manic disorder, spirit point
Split disease, spasm, bipolar disorders, apoplexy, Huntington disease, brain trauma, spinal injury and neurodegenerative disease.
Further, the neurodegenerative disease meaning includes senile dementia, Parkinson's disease, Huntington disease and amyotrophic lateral sclerosis
Lateral sclerosis.
Further, the drug includes oral preparation and non-oral administration preparation；The oral preparation includes tablet, ball
Agent, capsule, granule, microcapsule tablet, suspension, dripping pill, liquid oral；The non-oral administration preparation include inhalant,
Injection, aerosol, suppository, subcutaneous administration dosage form.
Further, the health-oriented products include cosmetics, showering agent and fragrance fumette.
The beneficial effects of the present invention are: the present invention provides a kind of preparation method of windproof essential oil, and discovery radix saposhnikoviae for the first time
Essential oil shows active medicine or big health-oriented products new application in experimental animal brain function and its disorder disease.It sends out for the first time
Existing radix saposhnikoviae essential oil or containing senile dementia, depression can be improved in windproof essential oil or its arbitrary composition in animal body model
The brain functions such as anxiety and its symptom of obstacle animal.Compared with the drug for the treatment of brain function and its obstacle at present, the radix saposhnikoviae essence
Oil or any combination thereof object has the mechanism that the polymoleculars such as neurotransmitter act synergistically on multiple target point that adjusts, and has good medicine
For parameter, it is easy to through blood-brain barrier, therefore there is raising/improved toxicological safety (i.e. toxicity reduction) improves/to change
The characteristics of kind metabolic stability, longer half-life period and/or lesser side effect, while it is living to generate biology that is similar or improving
Property (drug effect).The drug or health-oriented products of preparation can be used for preventing or treating brain function and its disorder disease and illness, such as burnt
Worry, depression, insomnia, convulsions, manic disorder, schizophrenia, spasm and bipolar disorders.Can also be used in cognitive function raising and
Improve.
Detailed description of the invention
Fig. 1 is the schematic diagram for the respond that windproof essential oil restores senile dementia zebra fish.
Specific embodiment
1, it summarizes
Present inventor's discovery, in compound induction senile dementia zebra fish model, windproof essential oil can significantly change
The cognition and respond of kind senile dementia zebra fish.In addition, also can effectively change in depressive anxiety zebra fish model
The depression with anxiety of kind zebra fish.That is, windproof essential oil is coordinated by polymolecular, and multiple target effect, treatment/alleviation
The related symptoms of brain function and its disorder disease, it is active without completely inhibiting, also there is not toxic side effect.
The pathological state of many brain functions and its disorder disease, for example, it is depression and anxiety, convulsions, anxiety, depression, insomnia, mad
Hot-tempered disease, schizophrenia, spasm and bipolar disorders, senile dementia etc., pathogenesis are complicated, single component or molecule difficulty with control
More or alleviate.Windproof essential oil is made of multiple bioactive molecules, and therefore, the individual with brain function and its disorder disease is acceptable to be contained
There is windproof essential oil involved in the present invention, or containing the composition containing windproof essential oil involved in the present invention.
2, exemplary pathological condition
Emotion emotional handicap: the clinical manifestation of emotion emotional handicap is mood elevation or low, with the flight of ideas or late
It is slow, psychomotor excitement or inhibition.This includes from a series of illnesss such as anxiety, depression, schizophrenia, such as mania, division
Affective disorder, schizophrenia, wound bipolar obstacle, panic situation and behavior paroxysmal syndrome out of control etc..According to
Windproof essential oil of the invention and pharmaceutical formulation and composition can be used for treating these diseases, symptom and the patient's condition, and itself and this
Existing therapeutic agent in one treatment classification is compared, and should show the improvement to side effect.
Neurodegenerative disease: neurodegenerative disease is to be with dyskinesia caused by the forfeiture of neuron or its myelin
The dyskinesia of feature.Deteriorate over time, to lead to dysfunction, such as Alzheimer's disease etc..The present invention
In radix saposhnikoviae and its derivative combination alleviate dyskinesia one or more symptoms.
Windproof essential oil and combinations thereof also is used as anxiolytic (antianxiety) agent in the present invention.
Windproof essential oil also is used as the chemical tools of brain function and its obstacle study of incident mechanism in the present invention
Brain function and its disorder disease and illness mean the obstacle or disease of nervous system, including but not limited to anxiety, suppression
Strongly fragrant, insomnia, convulsions, manic disorder, schizophrenia, spasm, bipolar disorders and Alzheimer's disease.
Neurodegenerative disease means disease such as, but not limited to below: senile dementia, parkinsonism etc..
Active drug preparation of the invention and composition can be used to treat brain function and its disorder disease and illness.Although this
A little medicine preparations are commonly used in the treatment of human patient, but they can be used for treating the similar or identical disease of other animals
Disease, other described animals such as primate, poultry (such as chicken, duck, goose), farm-animals (such as pig, ox), sports animals
(such as horse racing) and pet (such as dog and cat).
Pharmaceutical acceptable carrier of the present invention includes but is not limited to calcium carbonate, calcium phosphate, calcium sulfate, sucrose, glucose, cream
Sugar, fructose, xylitol, sorbierite, starch, gelatinized corn starch, cellulose derivative, gelatin, polyvinylpyrrolidone, sodium chloride,
Dextrin, stearic acid, magnesium stearate, calcium stearate, vegetable oil, polyethylene glycol, sterile phosphate buffered saline, salt water, woods grignard
Solution and their combination.
The peroral dosage form of the invention includes but is not limited to that (such as Enteric coated tablets, takes orally dripping pill solid oral dosage form
Piece, chewable tablets, granule, powder or capsule) or liquid oral dosage form (such as syrup or tincture).In addition, the radix saposhnikoviae in the present invention
Essential oil or combinations thereof object can also be added in cosmetics, bath article or big health-oriented products, for champignon, smell suction, massage,
It smears, bathing uses.In addition, windproof essential oil in the present invention or combinations thereof object can also be configured to chewing gum, it is oral to promote
Delivering and absorption.
Non-oral dosage forms of the present invention including but not limited to pass through injection or other administered by systemic routes, it is described its
Its systemic pathways such as transdermal administration or mucosal administration (such as intranasal, sublingual, mouth containing, Via vagina or rectum, pass through bolt
Agent).Other administration method (such as can veterinary application used in) include enteral and parenteral delivering, including muscle, subcutaneous
And/or intramedullary injection and intrathecal injection, direct intracerebroventricular, intravenous injection, intraperitoneal injection, nasal injection or eyeball
Interior injection.
Radix saposhnikoviae essential oil of the present invention can also be combined with other active components, to prepare other new pharmaceutical compositions.
Windproof essential oil of the invention or combinations thereof to alleviate above-mentioned symptom confirmation curative effect and treatment related activity, be
It is confirmed by the test of zebra fish, mouse species senile dementia and depression model and screening technique.
The therapeutic effect of aforementioned present invention radix saposhnikoviae essential oil or combinations thereof, good drug metabolism parameter and usual nontoxicity make
The compounds of this invention is obtained as the ideal medicament for treating above-mentioned illness.
Essentiality content of the invention is further illustrated with the embodiment of the present invention below, but not in any way to this
Invention limits, and is transformed or replaced, is all belonged to the scope of protection of the present invention based on any made by the present invention.
The preparation method of radix saposhnikoviae essential oil of the present invention, including steam distillation is extracted, CO 2 supercritical extracts.
Radix saposhnikoviae essential oil of the present invention is detected with gas chromatography-mass spectrometry device, by mass percentage its component
Are as follows: it is camphor (camphor) (> 14%), 3- carene (3-carene) (> 5%), D- limonene (D-limonene) (> 5%),
Bronyl acetate (bornyl acetate) (> 4%), β-bisabolene (β-bisabolene) (> 4%), (+)-sickleleaf celery alcohol
((+)-falcarinol) (> 3%).
Embodiment 1
Take windproof (Saposhnikovia divaricata (Turcz.) Schischk.) fresh or dry root, stem or
Leaf 100Kg, pile fermentation are placed 2 days, and the coarse granule of 50 mesh is crushed to, and it is 5.0 hydrochloric acid that coarse granule, which is soaked in 8 mass to measure pH value again,
In aqueous solution, extraction is overnight.It is respectively 0.8% cellulase and 0.3% pectin that mass percent, which is added, into extraction mixed liquor
Enzyme digests 2.5 hours at 37 DEG C.Above-mentioned sample and its mixed liquor are put into steam distillation to extract in instrument, 110 DEG C of reflux mention
It takes 7 hours, collects distillate, be cooled to room temperature to be placed in oil water separator and separate.Oil reservoir anhydrous sodium sulfate drying,
Separation is to get up to windproof essential oil.
Embodiment 2
Take windproof (Saposhnikovia divaricata (Turcz.) Schischk.) fresh or dry root, stem or
Leaf 50Kg, pile fermentation are placed 2 days, and the coarse granule of 50 mesh is crushed to, and it is 5.0 hydrochloric acid waters that coarse granule, which is soaked in 8 mass to measure pH value again,
In solution, extraction is overnight.It is respectively 0.8% cellulase and 0.3% pectin that mass percent, which is added, into extraction mixed liquor
Enzyme digests 2.5 hours at 37 DEG C.Above-mentioned sample and its mixed liquor are put into CO 2 supercritical to extract in instrument, extraction
46 DEG C of temperature, pressure 15.70MPa, time 85min, the flow velocity of carbon dioxide is 30kg/h；Essential oil is collected, molecule is placed in
It is refined in distillation apparatus, feeding temperature is 43 DEG C, and sample introduction speed is 510mL/h, and one section of evaporating temperature is 112 DEG C, dual circulation
Temperature is 63 DEG C, collects two sections of distillation fractions to get windproof essential oil.
Embodiment 3
Gas chromatography-mass spectrometry (GC-MS) analysis is carried out with the windproof essential oil that embodiment 1-2 is prepared.By quality
Its component of percentages are as follows: be camphor (camphor) (> 14%), 3- carene (3-carene) (> 5%), D- limonene (D-
Limonene) (> 5%), Bronyl acetate (bornyl acetate) (> 4%), β-bisabolene (β-bisabolene) (>
4%), (+)-sickleleaf celery alcohol ((+)-falcarinol) (> 3%).
Embodiment 4
Internal anti-senile dementia disease active testing is carried out with the windproof essential oil that embodiment 1-2 is prepared:
1) experimental animal
The zebra fish juvenile fish of experiment produces embryo by zebra fingerling fish and is incubated for naturally.Fish culture water water quality: every 1L
200mg Instant Ocean is added in reverse osmosis water, conductivity is 480~510 μ S/cm；PH is 6.9~7.2；Hardness be 53.7~
71.6mg/L CaCO3.After the completion of experiment, carried out with zebra fish of the tricaine methanesulfonic acid of 0.25mg/ml to each stage of development
Anesthesia is put to death.The operating procedure that anesthesia is put to death meets the code requirement that American Veterinary association (AVMA) puts to death Animal Anesthesia.
2) experimental design
5 groups of experiments are arranged in this research altogether, and every group of experiment is silly including 1 blank control group, 1 solvent control group, 1 old age
Slow-witted model group, 1 positive controls (donepezil), 2 windproof essential oils.The primary dcreening operation concentration of windproof essential oil is 6 μ g/mL, if going out
Existing dead or deformity, then choose 0.6 μ g/mL, tested.The zebra fish of alchlor processing is Senlie dementia model group；Three
The zebra fish that aluminium chloride and DPZ are jointly processed by is positive controls；The zebra fish that alchlor and untested compound are jointly processed by
For untested compound group；The zebra fish of 0.1% DMSO processing is negative control group (solvent control group)；Untreated zebra
Fish is blank control group, and each experimental group handles 30 tail zebra fish.Utilize zebra fish in behavioural analysis instrument record 60min
Motion profile is changed by light dark period, dark 10min, and 10min, 60min points of illumination are three light dark periods, then right
The movement velocity (dyskinesia) of zebra fish, light and shade period velocity variation (respond) carry out statistical analysis.
Active testing result meets quality control standard: 1. all experimental groups do not occur zebra fish in whole experiment process
Dead or deformity；2. model group and solvent control group compare with statistical difference (p < 0.001)；3. blank in all experiments
Control group no difference of science of statistics (p > 0.05) compared with solvent control group；4. positive controls (donepezil, DPZ) and model
Group compares with statistical difference (p < 0.05).
3) to the restitution of senile dementia zebra fish dyskinesia
All experiment Senlie dementia model group zebra fish movement velocitys are remarkably decreased, and have statistics compared with solvent control group
It learns meaning (p < 0.001)；Positive drug (DPZ) group zebra fish movement velocity is significantly gone up, and is anticipated compared with model group with statistics
Adopted (p < 0.01 or p < 0.001).Within the 60min light and shade period, movement velocity has regular, periodically and steady zebra fish
It is qualitative.The movement velocity of the windproof essential oil being prepared with embodiment 1 treated AD zebra fish significantly mentions compared with model group
High (p < 0.05, p < 0.01 or p < 0.001), the significant movement velocity (table 1 and Fig. 1) for restoring senile dementia zebra fish.
Table 1: the therapeutic efficiency of senile dementia zebra fish movement velocity
4) to the influence of senile dementia zebra fish respond
In all experiments, Senlie dementia model group zebra fish respond declines (under light and shade period velocity difference is significant
Drop), it is statistically significant compared with solvent control group (p < 0.001)；Positive drug (DPZ) organizes zebra fish respond part
Restore (light and shade period velocity difference is significantly gone up), with statistical significance (p < 0.05 or p < 0.001) compared with model group.
Respond (the light and shade week that can restore AD zebra fish in various degree after the windproof essential oil processing being prepared with embodiment 1
Phase speed difference significantly gos up), compared with model group, statistical difference it is significant or extremely significant (p < 0.05, p < 0.01 or p <
0.001) (table 2).
Table 2: the therapeutic efficiency of senile dementia zebra fish respond
Embodiment 5
Active testing is carried out with the windproof essential oil that embodiment 2 is prepared respectively, test method is same as Example 4, knot
Fruit shows that the windproof essential oil that the present invention is prepared can significantly improve the fortune of alchlor induction senile dementia zebra fish
Kinetic force and respond.
Embodiment 6: the preparation of windproof essential oil tablet
Windproof essential oil 10mL, medical starch 100g are uniformly mixed, and ethanol in proper amount is used to pelletize as adhesive, dry, through whole
Grain machine whole grain, tabletting, every 0.30g take orally, and 1 to 2 tablets once, twice daily.
Embodiment 7: the preparation of windproof essential oil capsules agent
Windproof essential oil 10mL, medical starch 100g are uniformly mixed, and ethanol in proper amount is used to pelletize as adhesive, dry, through whole
Grain machine whole grain, encapsulated, every 0.30g take orally, 1-2 tablets each time, twice daily.
Embodiment 8: the preparation of windproof essential oil granules agent
Windproof essential oil 10mL, medical starch 100g, Icing Sugar 500g are uniformly mixed, and ethanol in proper amount is used to pelletize as adhesive,
It is dry, through pelletizing machine whole grain, dispenses to obtain the final product, take orally, each 5g, twice daily
Embodiment 9: the preparation of windproof essential oil sucking preparation
Windproof essential oil 10mL, base oil 500mL, appropriate stabilizer and deodorant tune are uniformly mixed, and are dispensed to obtain the final product, sucking,
Each 10mL, twice daily.
Embodiment 10: the preparation of windproof essential oil massage oil
Windproof essential oil 10mL, base oil 500mL are uniformly mixed, and are dispensed to obtain the final product, and massage is 2-3 times daily.
Embodiment 11: the preparation of windproof essential oil bathing agent
Windproof essential oil 100mL, dispenses to obtain the final product, when bathing, instills in water and uses, and 2-3 times weekly.
Embodiment 12: the preparation of windproof essential oil champignon oil
Windproof essential oil 100mL, dispenses to obtain the final product, when champignon, instills in fumigating machine and uses, 2-3 times daily.
Above-described embodiment is used to illustrate the present invention, rather than limits the invention, in spirit of the invention and
In scope of protection of the claims, to any modifications and changes that the present invention makes, protection scope of the present invention is both fallen within.
Claims (8)
1. a kind of application of radix saposhnikoviae essential oil, which is characterized in that the application includes windproof essential oil in preparation treatment or prevention brain function
Application, windproof essential oil in the drug of energy and its disorder disease is in the health-oriented products that preparation improves brain function and its disorder disease
Application.
2. the application of windproof essential oil according to claim 1, which is characterized in that the radix saposhnikoviae essential oil is prepared by the following method
It obtains:
(1) it ferments: choosing dry windproof rhizome, pile fermentation is placed 1-2 days, and the coarse granule for being then crushed to 30-60 mesh is spare.
(2) extract: the coarse granule that step 1 is obtained is soaked in the hydrochloric acid that the pH value of 7-9 times of quality is 5.0-6.0 or sulfuric acid is water-soluble
In liquid, extraction overnight, obtains extraction mixed liquor.
(3) it digests: cellulase and pectase, cellulase, pectase and leaching being added into the extraction mixed liquor that step 2 obtains
Mention mixed liquor quality proportioning be 0.5-1:0.1-0.5:100,35-37 DEG C enzymatic hydrolysis 2-3 hours.
(4) it extracts, including following two method:
(4.1) mixed liquor after step 3 enzymatic hydrolysis is put into steam distillation to extract in instrument, 100 DEG C of -120 DEG C of refluxing extraction 5-7
A hour collects distillate, is cooled to room temperature to be placed in oil water separator and separates, and oil reservoir is dry with anhydrous sodium sulfate, separation,
Up to windproof essential oil；
(4.2) mixed liquor after step 3 enzymatic hydrolysis CO 2 supercritical being put into extract in instrument, the temperature of extraction is 45 DEG C-
48 DEG C, pressure 13.70MPa-17.80MPa, time 50min-100min, the flow velocity of carbon dioxide is 25kg/h-35kg/
h；Essential oil to be collected, is placed in molecular distillation instrument and refines, feeding temperature is 40 DEG C -45 DEG C, and sample introduction speed is 480-530mL/h,
One section of evaporating temperature is 110 DEG C -115 DEG C, and dual circulation temperature is 60 DEG C -65 DEG C, collects two sections of distillation fractions to get windproof essence
Oil.
3. the application of windproof essential oil according to claim 1, which is characterized in that the radix saposhnikoviae is that Umbelliferae radix saposhnikoviae platymiscium is anti-
Wind.
4. the application of windproof essential oil according to claim 1, which is characterized in that the radix saposhnikoviae essential oil gas chromatography-mass spectrum
With instrument analysis detection, by mass percentage, component ratio are as follows: camphor > 14%, 3- carene > 5%, D- limonene > 5%, second
Sour borneol acetate > 4%, β-bisabolene > 4%, (+)-sickleleaf celery alcohol > 3%.
5. the application of windproof essential oil according to claim 1, which is characterized in that the brain function and its disorder disease include coke
Worry, depression, insomnia, epilepsy, manic disorder, schizophrenia, spasm, bipolar disorders, apoplexy, Huntington disease, brain trauma, backbone damage
Wound and neurodegenerative disease.
6. the application of windproof essential oil according to claim 5, which is characterized in that the neurodegenerative disease meaning includes old age
Dementia, Parkinson's disease, Huntington disease and amyotrophic lateral sclerosis.
7. the application of windproof essential oil according to claim 1, which is characterized in that the drug includes oral preparation and non-oral
Drug-delivery preparation；The oral preparation includes tablet, pill, capsule, granule, microcapsule tablet, suspension, dripping pill, oral solution
Body；The non-oral administration preparation includes inhalant, injection, aerosol, suppository, subcutaneous administration dosage form.
8. the application of windproof essential oil according to claim 1, which is characterized in that the health-oriented products include cosmetics, bathing
Agent and fragrance fumette.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910566699.0A CN110201013A (en) | 2019-06-27 | 2019-06-27 | A kind of application of radix saposhnikoviae essential oil |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910566699.0A CN110201013A (en) | 2019-06-27 | 2019-06-27 | A kind of application of radix saposhnikoviae essential oil |
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| CN110201013A true CN110201013A (en) | 2019-09-06 |
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| CN201910566699.0A Withdrawn CN110201013A (en) | 2019-06-27 | 2019-06-27 | A kind of application of radix saposhnikoviae essential oil |
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| Country | Link |
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2019
- 2019-06-27 CN CN201910566699.0A patent/CN110201013A/en not_active Withdrawn
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