CN110200622B - Experimental measurement device for heart rate of mice - Google Patents

Experimental measurement device for heart rate of mice Download PDF

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Publication number
CN110200622B
CN110200622B CN201910583962.7A CN201910583962A CN110200622B CN 110200622 B CN110200622 B CN 110200622B CN 201910583962 A CN201910583962 A CN 201910583962A CN 110200622 B CN110200622 B CN 110200622B
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circuit board
heart rate
magic tape
chest cloth
mice
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CN110200622A (en
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董宁宁
崔锦江
徐建根
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Suzhou Institute of Biomedical Engineering and Technology of CAS
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Suzhou Institute of Biomedical Engineering and Technology of CAS
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/24Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/30Input circuits therefor
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/24Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/316Modalities, i.e. specific diagnostic methods
    • A61B5/318Heart-related electrical modalities, e.g. electrocardiography [ECG]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/68Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6801Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
    • A61B5/683Means for maintaining contact with the body
    • A61B5/6831Straps, bands or harnesses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2503/00Evaluating a particular growth phase or type of persons or animals
    • A61B2503/40Animals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2503/00Evaluating a particular growth phase or type of persons or animals
    • A61B2503/42Evaluating a particular growth phase or type of persons or animals for laboratory research

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medical Informatics (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

The invention discloses a heart rate experiment measurement device for mice, which comprises a chest cloth, an arc-shaped plate, a circuit board, a heart rate measurement module, a heart rate measurement head and a display screen, wherein a first magic tape round burr surface is arranged on one side surface of the chest cloth, a first magic tape thorn burr surface is arranged on the other side surface of the chest cloth, which is close to the end part, and the inner side of the arc-shaped plate, the chest cloth is adhered to the first magic tape thorn burr surface to form an annular cylinder through the first magic tape round burr surface, the arc-shaped plate is covered on the side wall of the annular cylinder, the first magic tape thorn burr surface on the inner side of the arc-shaped plate is adhered to the first magic tape round burr surface on the side surface of the chest cloth, the circuit board is arranged on one side of the arc-shaped plate, and the heart rate measurement module and the display screen are arranged on the circuit board.

Description

Experimental measurement device for heart rate of mice
Technical Field
The invention relates to the technical field of mice experiments, in particular to a device for measuring heart rate of mice.
Background
The mice commonly used for experiments mainly have the following reasons:
first: the gene sequence in mice is very similar to human, so that many diseases which are difficult to cure by human can find similar characters in mice, and the disease curing genes are found through experiments.
Second,: the biological significance of the special white mice for experiments is large, and the cultured mice have almost no individual difference (physiological significance). Whether there is no individual difference in physiology means that there is no difference in the air quality is not known, but the pure experimental white mice were selected mainly for reducing the individual differences of the congenital origin as much as possible.
Third,: the number is sufficient and many experiments require statistical analysis, which requires a certain number of rats and mice, especially mice, to meet this requirement under artificial propagation conditions. Also animal grade, mice anyhow are also mammals, except for small body sizes, which are not inferior to the evolutionary levels of other mammals. Small body size is a favorable condition for artificial breeding and feeding.
Fourth,: many experiments were best performed with animals such as orangutans that are more closely related to humans, but the use of orangutans is too expensive. Many experiments, such as cognitive, require animals to be killed at the end of the experiment to check for internal changes. Thus, a large number of experiments must not be performed with the more "valuable" gorilla.
Fifth,: since such large mammals are protected by the animal protection association. Then many experiments that are not "humane" are limited. Even if mice are used, the animals still have a resistance.
Sixth: some experiments were not performed on large, complex animals.
However, when the heart rate of the mice is detected, the mice are inconvenient to walk easily by the mice Bai Shu, the mice are mostly fixed by the existing detection means, the walking of the mice is limited, the mood of the mice is changed, and the heart rate variation of the mice is seriously affected. Therefore, we propose a device for experimental measurement of heart rate of mice.
Disclosure of Invention
The invention aims to provide a device for experimental measurement of heart rate of mice, which aims to solve the problems in the background technology.
In order to achieve the above purpose, the present invention provides the following technical solutions: the utility model provides a mice rhythm of heart experiment measuring device, includes chest cloth, arc, circuit board, rhythm of heart measurement module, rhythm of heart measurement head and display screen, one side of chest cloth is equipped with first magic subsides circle hair side, the opposite side of chest cloth is close to tip department and the inboard of arc all is equipped with first magic subsides thorn hair side, the chest cloth is pasted circle hair side and is pasted thorn hair side through first magic and bonds and form an annular cylinder, the arc cover is in annular cylinder lateral wall, and the inboard first magic of arc pastes thorn hair side and the first magic subsides circle hair side bonding of chest cloth side is fixed, the circuit board is installed to one side of arc back to the chest cloth, install rhythm of heart measurement module and display screen on the circuit board, the heart rate measurement module is connected with the display screen and the heart rate measurement head of setting outside the circuit board through the wire.
Preferably, a battery is fixed in the center of one side of the circuit board, and the battery is electrically connected with the circuit board through a wire.
Four mounting seats are arranged on one side of the arc-shaped plate far away from the chest cloth, the mounting seats and the arc-shaped plate are of an integrated structure, a fixing rod is fixed in each mounting seat, mounting holes are formed in the positions, opposite to the fixing rod, of four corners of the circuit board, the fixing rod is connected in the mounting holes in a sliding mode, springs are sleeved on the outer sides of the fixing rods, one end and mount pad fixed connection of spring, the other end and the circuit board contact of spring, the holding tank has been seted up to the lateral wall of dead lever, rotate through the pivot in the holding tank and be connected with the gag lever post, and the bottom and the circuit board upper surface contact of gag lever post, the top and the holding tank top contact of gag lever post.
Preferably, front leg avoiding holes are symmetrically formed in the chest cloth.
Preferably, the chest cloth is equipped with the second magic and pastes the round hair face in the one side of first magic subsides round hair face dorsad, heart rate measurement head one side is fixed with the second magic and pastes thorn hair face, and the second magic is pasted thorn hair face and is pasted round hair face with the second magic and match.
Preferably, the top of dead lever is equipped with the chamfer, the diameter of mounting hole is greater than dead lever diameter 0.1mm.
Preferably, when the limit rod rotates along the rotating shaft to be perpendicular to the fixing rod, the limit rod is completely positioned in the accommodating groove.
Preferably, a groove is formed in one side of the chest cloth, and the second magic tape round wool surface is arranged in the groove.
Compared with the prior art, the invention has the beneficial effects that:
The invention puts two front legs of a white mouse in two front leg avoiding holes, the heart position of the white mouse is opposite to a heart rate measuring head, so that a chest cloth is clung to the body of the white mouse, and a first magic tape round burr surface and a first magic tape thorn burr surface of the chest cloth are adhered to form an annular cylinder structure again; then, make the inboard first magic of arc paste thorn hair face and glue on the first magic of chest cloth side paste round hair face, accomplish the installation, the mouse can be carried away from whole device and remove, and the structure is simpler, avoids the action restriction to the mouse to avoid causing great influence to the mouse rhythm of the heart. The circuit board can be well damped through the springs, the good circuit board and all elements arranged on the circuit board are protected, meanwhile, the circuit board is convenient to detach and install, and further the circuit board is convenient to maintain.
Drawings
FIG. 1 is a schematic view showing the structure of the present invention after being mounted on a mouse body;
FIG. 2 is a schematic diagram of the structure of the present invention;
FIG. 3 is a second schematic diagram of the structure of the present invention;
FIG. 4 is a schematic diagram of the chest cloth structure of the present invention;
FIG. 5 is a schematic view of the inside structure of the arcuate plate of the present invention;
FIG. 6 is a schematic view of the outer side structure of the arcuate plate of the present invention;
Fig. 7 is a schematic view of the structure of the fixing rod of the present invention.
In the figure: 1. chest cloth; 2. the first magic tape is round; 3. an arc-shaped plate; 4. the first magic tape is stuck with a burr surface; 5. an annular cylinder; 6. a circuit board; 7. a heart rate measurement module; 8. a heart rate measurement head; 9. a display screen; 10. a battery; 11. a mounting base; 12. a fixed rod; 13. a mounting hole; 14. a spring; 15. a receiving groove; 16. a rotating shaft; 17. a limit rod; 18. front leg avoiding holes; 19. the second magic tape is round; 20. the second magic tape is stuck with a burr surface; 21. chamfering; 22. a groove.
Detailed Description
The following description of the embodiments of the present invention will be made clearly and completely with reference to the accompanying drawings, in which it is apparent that the embodiments described are only some embodiments of the present invention, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
Referring to fig. 1-7, the present invention provides a technical solution: the utility model provides a mice rhythm of heart experiment measuring device, includes chest cloth 1, arc 3, circuit board 6, rhythm of heart measurement module 7, rhythm of heart measurement head 8 and display screen 9, a side of chest cloth 1 is equipped with first magic and pastes round hair face 2, the opposite side of chest cloth 1 is close to tip department and the inboard of arc 3 all is equipped with first magic and pastes thorn hair face 4, chest cloth 1 is pasted round hair face 2 and first magic and is pasted thorn hair face 4 bonding formation annular cylinder 5 through first magic, and this annular cylinder 5 is used for holding the mice, arc 3 covers at annular cylinder 5 lateral wall, and the inboard first magic of arc 3 pastes the round hair face 2 bonding of thorn hair face 4 and chest cloth 1 side and fix, and the connected mode is simpler, and the circuit board 6 is installed to the opposite side of arc 3, install rhythm of heart measurement module 7 and display screen 9 on the circuit board 6, and display screen 9 are used for showing the data of mice, 7 and measurement head 8 are passed through with measurement module through to the heart rate measurement module 8 and are connected to the heart rate of heart rate measurement module 9 through the outside of measuring wire setting up at the heart rate measurement module 8.
A battery 10 is fixed in the center of one side of the circuit board 6, and the battery 10 is electrically connected with the circuit board 6 through a wire to supply power to each electronic component on the circuit board 6.
The chest cloth 1 is kept away from to arc 3 one side is equipped with four mount pads 11, and mount pad 11 and arc 3 are integrated into one piece structure, makes mount pad 11 and arc 3 be connected inseparabler, mount pad 11 internal fixation has dead lever 12, the four corners of circuit board 6 is just all equipped with mounting hole 13 to dead lever 12 department, and dead lever 12 sliding connection is in mounting hole 13, the cover is equipped with spring 14 in the dead lever 12 outside, and spring 14 is effectual carries out the shock attenuation to circuit board 6, the one end and the mount pad 11 fixed connection of spring 14, the other end and the circuit board 6 contact of spring 14, holding tank 15 has been seted up to the lateral wall of dead lever 12, be connected with gag lever post 17 through pivot 16 rotation in the holding tank 15, restrict circuit board 6 through gag lever post 17 and spring 14 to upper and lower both sides face, fine protect circuit board 6, simultaneously the convenient dismantlement circuit board 6, and the bottom and the upper surface contact of gag lever post 17, the top and the holding tank 15 top contact of gag lever post 17.
The chest cloth 1 is symmetrically provided with front leg avoiding holes 18, so that the front legs of the mice can be conveniently fixed, and the chest cloth 1 is prevented from moving on the mice.
The round hair face 19 is pasted to one side that the round hair face 2 was pasted to the chest cloth 1 dorsad to first magic, heart rate measurement head 8 side is fixed with second magic and pastes thorn hair face 20, and second magic is pasted thorn hair face 20 and is pasted round hair face 19 and cooperate, is convenient for to heart rate measurement head 8, guarantees at the in-process of detection that heart rate measurement head 8 does not produce the removal of relative chest cloth 1 and mice, and then guarantees measuring accuracy.
The top of dead lever 12 is equipped with chamfer 21, the diameter of mounting hole 13 is greater than dead lever 12 diameter 0.1mm, prevents circuit board 6 from controlling violently rocking, protects circuit board 6.
When the limiting rod 17 rotates along the rotating shaft 16 to the position where the fixing rod 12 is vertical, the limiting rod 17 is completely located in the accommodating groove 15, so that the fixing rod 12 can be smoothly moved out of the mounting hole 13, and further, the circuit board 6 is smoothly detached.
The chest cloth 1 one side is equipped with recess 22, and the round hair face 19 is pasted to the second magic is set up in recess 22, avoids heart rate measurement head 8 protruding too thick, and the pressure to the heart of mice is too big, causes the influence to the heart rate of mice.
The working principle is as follows:
firstly, separating the chest cloth 1 from the arc-shaped plate 3, and expanding an annular cylinder 5 structure formed by the chest cloth 1 by self;
subsequently, sticking a second magic tape thorn hair surface 20 on one side of the heart rate measuring head 8 onto the second magic tape round hair surface 19;
Secondly, placing two front legs of a white mouse in the two front leg avoiding holes 18, enabling the heart position of the white mouse to be opposite to the heart rate measuring head 8, enabling the chest cloth 1 to be clung to the body of the white mouse, and bonding the first magic tape round hair surface 2 and the first magic tape thorn hair surface 4 of the chest cloth 1 to form an annular cylinder 5 structure again;
then, the first magic tape thorn hair surface 4 on the inner side of the arc plate 3 is stuck on the first magic tape round hair surface 2 on the side surface of the chest cloth 1, so that the installation is completed, and the mice can move back to the whole device.
The circuit board 6 is not protected by adding a shell, so that the weight is reduced, the influence on the heart rate of the mice is reduced, and the spring 14 can well absorb shock of the circuit board 6 and protect the circuit board 6 in the movement process of the mice.
Process of detaching the circuit board 6: firstly, the circuit board 6 is pressed down, the spring 14 is compressed, the accommodating groove 15 is completely exposed above the circuit board 6, the limiting rods 17 are rotated, the four limiting rods 17 are completely located in the accommodating groove 15, at the moment, the circuit board 6 is separated from the constraint of the limiting rods 17, the fixing rod 12 can be moved out of the mounting hole 13, the circuit board 6 is convenient to detach, and the circuit board 6 is convenient to maintain and store.
Process of mounting the circuit board 6: firstly, four mounting holes 13 of a circuit board 6 are aligned with four fixing rods 12, the circuit board 6 is pressed down, a spring 14 is compressed, an accommodating groove 15 is fully exposed above the circuit board 6, a limiting rod 17 is rotated, the limiting rod 17 and the circuit board 6 are in a mutually parallel state, the limiting rod 17 is in friction with a contact part of the accommodating groove 15, the parallel state of the limiting rod 17 can still be maintained when a hand loosens the limiting rod 17, the four limiting rods 17 are sequentially rotated to enable the four limiting rods 17 to be mutually parallel with the circuit board 6, then the hand pressing the circuit board 6 is loosened, and due to the action of the spring 14, two side faces of the circuit board 6 are respectively contacted with the top end of the spring 14 and the limiting rod 17, and the mounting is completed.
It is noted that relational terms such as first and second, and the like are used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Moreover, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus.
Although embodiments of the present invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made therein without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.

Claims (1)

1. The utility model provides a mice heart rate experiment measuring device, includes chest cloth (1), arc (3), circuit board (6), heart rate measurement module (7), heart rate measuring head (8) and display screen (9), its characterized in that: a first magic tape circular burr surface (2) is arranged on one side surface of the chest cloth (1), a first magic tape circular burr surface (4) is arranged on the other side surface of the chest cloth (1) close to the end part and the inner side of the arc plate (3), the chest cloth (1) is adhered to form an annular cylinder (5) through the first magic tape circular burr surface (2) and the first magic tape circular burr surface (4), the arc plate (3) is covered on the side wall of the annular cylinder (5), the first magic tape circular burr surface (4) on the inner side of the arc plate (3) is adhered and fixed with the first magic tape circular burr surface (2) on the side surface of the chest cloth (1), a circuit board (6) is arranged on one side, opposite to the chest cloth (1), of the arc plate (3), a heart rate measurement module (7) and a display screen (9) are arranged on the circuit board (6), and the heart rate measurement module (7) is connected with the display screen (9) and a heart rate measurement head (8) arranged outside the circuit board (6) through wires; the heart rate measuring head (8) transmits the detected data to the heart rate measuring module (7) through a lead for analysis and processing, and finally, the data are displayed through the display screen (9);
A battery (10) is fixed in the center of one side of the circuit board (6), and the battery (10) is electrically connected with the circuit board (6) through a lead to supply power to each electronic component on the circuit board (6);
Four mounting seats (11) are arranged on one side, far away from the chest cloth (1), of the arc plate (3), the mounting seats (11) and the arc plate (3) are of an integrated structure, fixing rods (12) are fixedly arranged in the mounting seats (11), mounting holes (13) are formed in the positions, opposite to the fixing rods (12), of four corners of the circuit board (6), the fixing rods (12) are slidably connected in the mounting holes (13), springs (14) are sleeved on the outer sides of the fixing rods (12), one ends of the springs (14) are fixedly connected with the mounting seats (11), the other ends of the springs (14) are in contact with the circuit board (6), accommodating grooves (15) are formed in the side walls of the fixing rods (12), limiting rods (17) are connected in the accommodating grooves (15) through rotating shafts (16), the upper side surfaces and the lower side surfaces of the circuit board (6) are limited through the limiting rods (17) and the springs (14), and meanwhile, the circuit board (6) are conveniently detached; the bottom of the limiting rod (17) is contacted with the upper surface of the circuit board (6), and the top of the limiting rod (17) is contacted with the top of the accommodating groove (15);
front leg avoiding holes (18) are symmetrically formed in the chest cloth (1) to prevent the chest cloth (1) from moving on the body of the mice;
A second magic tape round burr surface (19) is arranged on one side of the chest cloth (1) opposite to the first magic tape round burr surface (2), a second magic tape thorn burr surface (20) is fixed on one side of the heart rate measuring head (8), and the second magic tape thorn burr surface (20) is matched with the second magic tape round burr surface (19); the heart rate measuring head (8) is convenient to carry out, and the heart rate measuring head (8) is ensured not to move relative to the chest cloth (1) and the mice in the detection process, so that the measurement accuracy is ensured;
The top end of the fixed rod (12) is provided with a chamfer (21), and the diameter of the mounting hole (13) is 0.1mm larger than the diameter of the fixed rod (12); the circuit board (6) is prevented from shaking left and right severely, and the circuit board (6) is protected;
When the limiting rod (17) rotates along the rotating shaft (16) to be perpendicular to the fixed rod (12), the limiting rod (17) is completely positioned in the accommodating groove (15); the fixing rod (12) can be smoothly moved out of the mounting hole (13), so that the circuit board (6) is smoothly detached;
A groove (22) is formed in one side of the chest cloth (1), and a second magic tape round wool surface (19) is arranged in the groove (22); the influence on the heart rate of the mice caused by overlarge pressure on the heart of the mice due to overlarge heart rate measuring head (8) is avoided;
The working principle is as follows:
firstly, separating the chest cloth (1) from the arc-shaped plate (3), and expanding an annular cylinder (5) structure surrounded by the chest cloth (1) per se;
Then, sticking a second magic tape burr surface (20) on one side surface of the heart rate measuring head (8) on the second magic tape burr surface (19);
Secondly, placing two front legs of a white mouse in two front leg avoiding holes (18), wherein the heart position of the white mouse is opposite to a heart rate measuring head (8) at the moment, enabling a chest cloth (1) to be clung to the body of the white mouse, and adhering a first magic tape round hair surface (2) and a first magic tape thorn hair surface (4) of the chest cloth (1) to form an annular cylinder (5) structure again;
Then, the first magic tape thorn hair surface (4) on the inner side of the arc-shaped plate (3) is stuck on the first magic tape round hair surface (2) on the side surface of the chest cloth (1), so that the installation is completed, and a mouse can move back to the whole device;
the circuit board (6) is not added with a shell for protection, so that the weight is reduced, the influence on the heart rate of the mice is reduced, the springs (14) absorb shock to the circuit board (6) in the process of the movement of the mice,
The process of disassembling the circuit board (6): firstly, the circuit board (6) is pressed down, the springs (14) are compressed, the accommodating grooves (15) are fully exposed above the circuit board (6), the limiting rods (17) are rotated, the four limiting rods (17) are fully positioned in the accommodating grooves (15), at the moment, the circuit board (6) is separated from the limit rods (17), the fixing rods (12) can be moved out of the mounting holes (13), the circuit board (6) can be detached conveniently, and the circuit board (6) can be maintained and accommodated conveniently;
Process of mounting a circuit board (6): the method comprises the steps of aligning four mounting holes (13) of a circuit board (6) with four fixing rods (12), pressing down the circuit board (6), compressing a spring (14), enabling an accommodating groove (15) to be completely exposed above the circuit board (6), rotating a limiting rod (17), enabling the limiting rod (17) to be in a mutually parallel state with the circuit board (6), and enabling hands to loosen the limiting rod (17) due to friction between the limiting rod (17) and a contact part of the accommodating groove (15), wherein the parallel state can still be kept, sequentially enabling the four limiting rods (17) to rotate to enable the four limiting rods to be parallel to the circuit board (6), then loosening the hands pressing the circuit board (6), and completing installation due to the effect of the spring (14), wherein two side faces of the circuit board (6) are respectively contacted with the top end of the spring (14) and the limiting rod (17).
CN201910583962.7A 2019-06-12 2019-06-12 Experimental measurement device for heart rate of mice Active CN110200622B (en)

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