CN1101978A - Rapid test method for KCE content in compound NaCl injection - Google Patents
Rapid test method for KCE content in compound NaCl injection Download PDFInfo
- Publication number
- CN1101978A CN1101978A CN 93118910 CN93118910A CN1101978A CN 1101978 A CN1101978 A CN 1101978A CN 93118910 CN93118910 CN 93118910 CN 93118910 A CN93118910 A CN 93118910A CN 1101978 A CN1101978 A CN 1101978A
- Authority
- CN
- China
- Prior art keywords
- sodium chloride
- compound sodium
- chloride injection
- kce content
- test method
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- Investigating Or Analysing Biological Materials (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
An ion-selective electrode and a direct potential method are used to test the KCl content in compound NaCl injection with error of less than 0.6% and test time of 30 min. for first time and 3 min. for testing again. It features simple, accurate, fast and economical test.
Description
KCE content detection method in the compound sodium chloride injection adopts " method of regulation, i.e. gravimetric method in the Chinese pharmacopoeia (version was two ones in 1990,370 pages) always.Because this method needs 8-10 hour detection time approximately, thereby makes the determination and analysis cycle of KCE content in the compound sodium chloride injection long, the cost height is unfavorable for the production monitoring and the quality control of this medicine.
The present invention is directed to the problems referred to above, purpose provides a kind of easy, method of inspection fast and accurately, to realize this pharmaceutical production intermediate quality control, improves finished medicines checkability and accuracy rate.
The method of taking of the present invention is: preparing standard solution at first.Get NaCl and CaCl
2Adding water in right amount makes and contains NaCl 8.6mg/ml and CaCl
20.32mg/ml solution, abbreviate A liquid as, the 105 ℃ of KCl of drying to constant weight that learn from else's experience accurate claim surely, add water and make the solution that contains KC10.2mg/ml, are called for short B liquid; Get A liquid 50ml, B liquid 50.0ml, thin up be to 250.0ml, mixing, and this solution abbreviates C as
I; Get A liquid 50ml, B liquid 100.0ml, thin up be to 250.0ml, mixing, and this solution abbreviates C as
IIC
IAnd C
IIBe standard solution.
On the basis of the above, can adopt following method to measure.
Form the measurement battery with potassium ion-selective electrode and mercurous chloride electrode, measure C respectively
I, C
IIWith compound sodium chloride injection C to be measured
XCurrent potential, obtain E
Cl, E
The C IIAnd E
CX, press following formula promptly.
logC
x= 0.301 (E
cx- E
cx)/(Ec
1- Ec
1) + logC
1
Adopt this method to detect KCE content in the compound sodium chloride injection, because NaCl and CaCl to exist in the compound sodium chloride injection
2As ionic strength adjustor, thereby system is simple.Titer is consistent with the compound sodium chloride injection composition simultaneously, and measuring error is reduced.With " method of Chinese pharmacopoeia regulation compares, and error is less than 0.6%(n=7), the recovery 99.5% is measured approximately first and is needed 30 minutes, measures once more and can finish in 3 minutes.Supplies consumption also greatly reduces, so this detection method has easy, accurate, quick, economic characteristics.
Claims (2)
1, the detection method of KCE content in a kind of compound sodium chloride injection is characterized in that NaCl and CaCl to exist in the compound sodium chloride injection
2As ionic strength adjustor, and make titer form consistent with compound sodium chloride injection.
2, the detection method of KCE content in the compound sodium chloride injection as claimed in claim 1, it is characterized in that forming the measurement battery, draw measured value by the current potential of bioassay standard liquid and compound sodium chloride injection and through conversion with potassium ion-selective electrode and mercurous chloride electrode.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 93118910 CN1101978A (en) | 1993-10-19 | 1993-10-19 | Rapid test method for KCE content in compound NaCl injection |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 93118910 CN1101978A (en) | 1993-10-19 | 1993-10-19 | Rapid test method for KCE content in compound NaCl injection |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1101978A true CN1101978A (en) | 1995-04-26 |
Family
ID=4992708
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 93118910 Pending CN1101978A (en) | 1993-10-19 | 1993-10-19 | Rapid test method for KCE content in compound NaCl injection |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1101978A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101871912A (en) * | 2010-06-07 | 2010-10-27 | 浙江大学 | Full-solid potassium ion sensor and preparation method thereof |
| CN103185740A (en) * | 2011-12-28 | 2013-07-03 | 株式会社堀场制作所 | Correction liquid |
-
1993
- 1993-10-19 CN CN 93118910 patent/CN1101978A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101871912A (en) * | 2010-06-07 | 2010-10-27 | 浙江大学 | Full-solid potassium ion sensor and preparation method thereof |
| CN101871912B (en) * | 2010-06-07 | 2013-04-24 | 浙江大学 | Full-solid potassium ion sensor and preparation method thereof |
| CN103185740A (en) * | 2011-12-28 | 2013-07-03 | 株式会社堀场制作所 | Correction liquid |
| US9377429B2 (en) | 2011-12-28 | 2016-06-28 | Horiba, Ltd. | Calibration liquid |
| CN103185740B (en) * | 2011-12-28 | 2018-02-16 | 株式会社堀场制作所 | calibration method |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C01 | Deemed withdrawal of patent application (patent law 1993) | ||
| WD01 | Invention patent application deemed withdrawn after publication |