CN110180465A - A kind of micro liquid mixed reactor - Google Patents
A kind of micro liquid mixed reactor Download PDFInfo
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- CN110180465A CN110180465A CN201910559209.4A CN201910559209A CN110180465A CN 110180465 A CN110180465 A CN 110180465A CN 201910559209 A CN201910559209 A CN 201910559209A CN 110180465 A CN110180465 A CN 110180465A
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- 239000007788 liquid Substances 0.000 title claims abstract description 112
- 239000012634 fragment Substances 0.000 claims abstract description 27
- NJPPVKZQTLUDBO-UHFFFAOYSA-N novaluron Chemical compound C1=C(Cl)C(OC(F)(F)C(OC(F)(F)F)F)=CC=C1NC(=O)NC(=O)C1=C(F)C=CC=C1F NJPPVKZQTLUDBO-UHFFFAOYSA-N 0.000 claims abstract description 14
- 239000011521 glass Substances 0.000 claims abstract description 10
- 239000000463 material Substances 0.000 claims abstract description 6
- 230000003287 optical effect Effects 0.000 claims description 7
- 230000008054 signal transmission Effects 0.000 claims description 5
- 239000002184 metal Substances 0.000 claims description 4
- 239000000203 mixture Substances 0.000 claims description 2
- 238000006243 chemical reaction Methods 0.000 abstract description 6
- 239000012530 fluid Substances 0.000 abstract description 6
- 238000000034 method Methods 0.000 abstract description 4
- 230000000694 effects Effects 0.000 abstract description 3
- 239000000376 reactant Substances 0.000 abstract description 2
- 238000010586 diagram Methods 0.000 description 4
- 238000009434 installation Methods 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 239000012295 chemical reaction liquid Substances 0.000 description 1
- 230000001678 irradiating effect Effects 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
Classifications
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/0093—Microreactors, e.g. miniaturised or microfabricated reactors
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/18—Stationary reactors having moving elements inside
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J4/00—Feed or outlet devices; Feed or outlet control devices
- B01J4/02—Feed or outlet devices; Feed or outlet control devices for feeding measured, i.e. prescribed quantities of reagents
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
Abstract
The present invention relates to new materials to research and develop field, a kind of micro liquid mixed reactor, including computer, laser, lens group, camera, pedestal, rotation motor, rotary shaft, revolving fragment, liquid mixer and limited screw, liquid mixer includes glass slide, sample cell I, sample cell II, microchannel I, microchannel II, mixing chamber, microchannel III and liquid storage tank, miniflow body cavity and microchannel structure with special designing, using the mixed method based on centrifugal force, it can quickly be mixed to nanoliter to the reactant liquid of microlitre volume, it can be used in the mixing and reaction of small volume of fluid response sample, microfluidic elements based on centrifugal force, it can be used in the continuous mixing and reaction of 30 microlitres of small volume of fluid samples below, device is preferable to the mixed effect of the fluid sample of small size, it is at low cost, behaviour Facilitate.
Description
Technical field
Research and develop field the present invention relates to new material, it is especially a kind of can be quickly to the reaction thing liquid for nanoliter arriving microlitre volume
A kind of micro liquid mixed reactor that body is mixed.
Background technique
It is an important factor for carrying out efficient chemical reaction, especially in low dose of chemistry point to being sufficiently mixed for reactant
In analysis application, completely quantitative mixing is to be related to the determinant of analysis precision, and many of prior art is to a large amount of anti-
Answer the solution that object is mixed, still, for nanoliter arrive microlitre magnitude reaction liquid, there are no a kind of sides of low cost
For method come for being sufficiently mixed, a kind of micro liquid mixed reactor is able to solve problem.
Summary of the invention
To solve the above-mentioned problems, apparatus of the present invention have the microfluidic elements based on centrifugal force, can be used in 30 microlitres
The continuous mixing and reaction of small volume of fluid sample below.
The technical scheme adopted by the invention is that:
A kind of micro liquid mixed reactor includes computer, laser, lens group, camera, pedestal, rotation
Motor, rotary shaft, revolving fragment, liquid mixer and limited screw, xyz are three-dimensional system of coordinate, liquid mixer include glass slide,
Sample cell I, sample cell II, microchannel I, microchannel II, mixing chamber, microchannel III and liquid storage tank, liquid mixer have two sets；
Laser and camera are all connected with computer, and lens group is located at before laser, the position of laser, lens group and camera
Adjustable, rotation motor is installed on chassis interior, and the speed of rotation motor is adjustable, and rotary shaft is along the vertical direction y, rotation
The lower end of shaft is connected to rotation motor, the top of pedestal is exposed in upper end；With the rectangle metal of screw hole centered on revolving fragment
Piece, revolving fragment is connected to the upper end of rotary shaft by screw hole, and is fixed by limited screw, and two sets of liquid mixers are symmetrically pacified
Loaded on the upper surface of revolving fragment, rotation motor is able to drive two sets of liquid mixers in the horizontal rotation in surface of xy；Camera is located at rotation
15 centimeters above rotor, and can be adjusted by computer sharp by collected optical signal transmission into computer
The time response of the laser pulse of light device transmitting, the laser of laser transmitting is by that after lens group, can be irradiated to liquid mixing
Device；Sample cell I, sample cell II, microchannel I, microchannel II, mixing chamber, microchannel III and liquid storage tank are by a monolith macromolecule material
Tablet, which is integrally machined, to be shaped and fits closely with the upper surface of glass slide, one end of the microchannel I and microchannel II that are parallel to each other
It is respectively communicated with sample cell I and is connected to mixing chamber with sample cell II, the other end, mixing chamber is connected to liquid storage tank by microchannel III, micro-
Channel III is in U-shape in xy horizontal plane, and liquid is curved by forming 180 degree when the III of microchannel, and microchannel III is by being divided into 1.5
Three microchannels composition of millimeter；The upper surface of sample cell I and sample cell II all have the inlet that a diameter is 0.5 millimeter,
The inlet is sample cell I, sample cell II, microchannel I, microchannel II, mixing chamber, microchannel III and liquid storage tank and atmosphere
The opening of connection；The depth of sample cell I, sample cell II and liquid storage tank are 250 microns, the volume of sample cell I and sample cell II
It is 15 microlitres, the volume of liquid storage tank is 40 microlitres；The length of microchannel I and microchannel II are 10 millimeters, microchannel I and micro-
The section of channel II is that height is 250 microns, the rectangle that width is 70 microns；The depth of mixing chamber is 70 microns, volume
It is 35 microlitres；The section of three microchannels of microchannel III is that height is 250 microns, the rectangle that width is 50 microns.
The step of being tested using a kind of micro liquid mixed reactor are as follows:
Step 1 is filled with 15 microlitres to the inlet of sample cell I and sample cell II respectively simultaneously using two pipettors
Liquid I to be mixed and 15 microlitres of liquid II to be mixed, liquid mixer is installed to revolving fragment, so that sample in liquid mixer
Side where product pond I and sample cell II is close to the center of revolving fragment；
Step 2 opens rotation motor, adjusts the speed of rotation motor, is increased linearly up in 5 second time from 0Hz
Liquid I to be mixed and liquid II to be mixed in 10Hz, sample cell I and sample cell II pass through microchannel I and microchannel II respectively
Flow to mixing chamber；
Step 3 continues the speed for adjusting rotation motor, continued linearly to increase to 20Hz within 8 second time and protect
It holds 60 seconds, the liquid in mixing chamber flows to liquid storage tank by microchannel III, and makes a part existing for script in liquid storage tank empty
Gas is compressed in liquid storage tank；
Step 4 continues the speed for adjusting rotation motor, was linearly reduced within 30 second time to 0Hz, liquid storage tank
In mixed liquid is pushed back in mixing chamber by compressed air；
Step 5, repeats step 2 to step 43 times, to guarantee in mixer that liquid is mixed thoroughly and is eventually located at
In mixing chamber；
Step 6 adjusts the position of laser and lens group, so that the laser of laser transmitting is by irradiating after lens group
To the mixing chamber of liquid mixer；
Step 7, adjusts the position of camera, and acquires the image of liquid and relevant optical information in liquid mixer,
And by collected optical signal transmission into computer；
The optical signal in computer is analyzed and handled to step 8, after judging liquid I to be mixed and liquid II to be mixed mixing
Product characteristic.
The beneficial effects of the present invention are:
Apparatus of the present invention are preferable to the mixed effect of the fluid sample of small size, at low cost, easy to operate.
Detailed description of the invention
It is further illustrated below with reference to figure of the invention:
Fig. 1 is schematic diagram of the present invention；
Fig. 2 is revolving fragment schematic top plan view；
Fig. 3 is that liquid mixer overlooks enlarged diagram.
In figure, 1. computers, 2. lasers, 3. lens groups, 4. cameras, 5. pedestals, 6. rotation motors, 7. rotary shafts,
8. revolving fragment, 9. liquid mixers, 9-1. glass slide, 9-2. sample cell I, 9-3. sample cell II, 9-4. microchannel I, 9-5. are micro-
Channel II, 9-6. mixing chamber, the microchannel 9-7. III, 9-8. liquid storage tank, 10. limited screws.
Specific embodiment
If Fig. 1 is schematic diagram of the present invention, if Fig. 2 is revolving fragment schematic top plan view, including computer (1), laser (2),
Lens group (3), camera (4), pedestal (5), rotation motor (6), rotary shaft (7), revolving fragment (8), liquid mixer (9) and limit
Position screw (10), xyz is three-dimensional system of coordinate, and laser (2) and camera (4) are all connected with computer (1), and lens group (3) is located at
Before laser (2), the position of laser (2), lens group (3) and camera (4) is adjustable, rotation motor (6) installation
Internal in pedestal (5), the speed of rotation motor (6) is adjustable, and rotary shaft (7) is under the vertical direction y, rotary shaft (7)
End is connected to rotation motor (6), the top of pedestal (5) is exposed in upper end, the rectangle metal with screw hole centered on revolving fragment (8)
Piece, revolving fragment (8) are connected to the upper end of rotary shaft (7) by screw hole, and fixed by limited screw (10), two sets of liquid mixing
Device (9) is symmetrically installed on the upper surface of revolving fragment (8), and rotation motor (6) is able to drive two sets of liquid mixers (9) in xy level
Rotation in surface；Camera (4) is located at 15 centimeters above revolving fragment (8), and can be by collected optical signal transmission to meter
In calculation machine (1), the time response of the laser pulse of laser (2) transmitting, laser (2) hair can be adjusted by computer (1)
After the laser penetrated passes through lens group (3), liquid mixer (9) can be irradiated to.
If Fig. 3 is that liquid mixer overlooks enlarged diagram, liquid mixer (9) includes glass slide (9-1), sample cell I
(9-2), sample cell II (9-3), microchannel I (9-4), microchannel II (9-5), mixing chamber (9-6), microchannel III (9-7) and storage
Liquid pool (9-8), liquid mixer (9) have two sets, sample cell I (9-2), sample cell II (9-3), microchannel I (9-4), microchannel
II (9-5), mixing chamber (9-6), microchannel III (9-7) and liquid storage tank (9-8) are integrally machined by a monolith high molecular material piece
Shape simultaneously fits closely, one end of the microchannel I (9-4) and microchannel II (9-5) that are parallel to each other with the upper surface of glass slide (9-1)
It is respectively communicated with sample cell I (9-2) to be connected to mixing chamber (9-6) with sample cell II (9-3), the other end, mixing chamber (9-6) passes through micro-
Channel III (9-7) is connected to liquid storage tank (9-8), and microchannel III (9-7) is in U-shape in xy horizontal plane, and liquid is by microchannel III
Form that 180 degree is curved, and microchannel III (9-7) is made of three microchannels for being divided into 1.5 millimeters when (9-7)；Sample cell I (9-2)
The inlet that a diameter is 0.5 millimeter is all had with the upper surface of sample cell II (9-3), the inlet is sample cell I (9-
2), sample cell II (9-3), microchannel I (9-4), microchannel II (9-5), mixing chamber (9-6), microchannel III (9-7) and liquid storage
The opening that pond (9-8) is communicated with the atmosphere；The depth of sample cell I (9-2), sample cell II (9-3) and liquid storage tank (9-8) are 250
The volume of micron, sample cell I (9-2) and sample cell II (9-3) are 15 microlitres, and the volume of liquid storage tank (9-8) is 40 microlitres；It is micro-
The length of channel I (9-4) and microchannel II (9-5) are 10 millimeters, and the section of microchannel I (9-4) and microchannel II (9-5) are equal
Being highly is 250 microns, the rectangle that width is 70 microns；The depth of mixing chamber (9-6) is 70 microns, volume is 35 microlitres；
The section of three microchannels of microchannel III (9-7) is that height is 250 microns, the rectangle that width is 50 microns.
The working principle of device: by sample cell I (9-2) and sample cell II (9-3) respective inlet, to sample cell I
It is filled with 15 microlitres of liquid I to be mixed and 15 microlitres of liquid II to be mixed respectively in (9-2) and sample cell II (9-3), liquid is mixed
To revolving fragment (8), the side in liquid mixer (9) where sample cell I (9-2) and sample cell II (9-3) is leaned on for clutch (9) installation
The center of nearly revolving fragment (8) is opened rotation motor (6), rotation motor (6) drive liquid mixer (9) in xy horizontal plane around
Rotary shaft (7) rotation, and increase rotation motor (6) revolving speed, when the centrifugal force effect of generation is greater than liquid at microchannel I (9-4)
When with capillarity in microchannel II (9-5), liquid I to be mixed in sample cell I (9-2) and sample cell II (9-3) and
Liquid II to be mixed passes through microchannel I (9-4) respectively and microchannel II (9-5) flows to mixing chamber (9-6), with mixer (9)
Continuous rotation, the liquid in mixing chamber (9-6) flows to liquid storage tank (9-8) by microchannel III (9-7), and makes liquid storage tank
Portion of air existing for script is compressed in liquid storage tank (9-8) in (9-8), described to be by the pressure of compressed airWherein VcaFor volume shared by the air that is compressed in liquid storage tank (9-8), VcFor liquid storage tank (9-8)
Volume, P0For an atmospheric pressure；Due to being flowed into liquid storage tank (9-8) after liquid I to be mixed and liquid II to be mixed mixing, pressed
The pressure of contracting air increases, in order to enable the flow rate of liquid in mixing chamber (9-6) is kept constant, needs to increase mixer (9) rotation
The angular frequency turned adjusts rotation motor (6) revolving speed, gradually once not having liquid in sample cell I (9-2) and sample cell II (9-3)
Reduce the angular frequency of mixer (9) rotation so that centrifugal force declines, in liquid storage tank (9-8) will be mixed by compressed air
Liquid pushes back in mixing chamber (9-6).
A kind of micro liquid mixed reactor includes computer (1), laser (2), lens group (3), camera
(4), pedestal (5), rotation motor (6), rotary shaft (7), revolving fragment (8), liquid mixer (9) and limited screw (10), xyz are
Three-dimensional system of coordinate, liquid mixer (9) include glass slide (9-1), sample cell I (9-2), sample cell II (9-3), microchannel I (9-
4), microchannel II (9-5), mixing chamber (9-6), microchannel III (9-7) and liquid storage tank (9-8), liquid mixer (9) have two sets；
Laser (2) and camera (4) are all connected with computer (1), and lens group (3) is located at before laser (2), laser (2), thoroughly
The position of microscope group (3) and camera (4) is adjustable, and rotation motor (6) is installed on pedestal (5) inside, the rotation of rotation motor (6)
It is adjustable to turn frequency, rotary shaft (7) is along the vertical direction y, and the lower end of rotary shaft (7) is connected to rotation motor (6), bottom is exposed in upper end
The top of seat (5)；There is the rectangle sheet metal of screw hole, revolving fragment (8) is connected to rotation by screw hole centered on revolving fragment (8)
The upper end of axis (7), and it is fixed by limited screw (10), and two sets of liquid mixers (9) are symmetrically installed on the upper of revolving fragment (8)
Face, rotation motor (6) are able to drive two sets of liquid mixers (9) in the horizontal rotation in surface of xy；Camera (4) is located at revolving fragment
(8) 15 centimeters above, and can be adjusted in collected optical signal transmission to computer (1) by computer (1)
The time response of the laser pulse of laser (2) transmitting is saved, after the laser of laser (2) transmitting passes through lens group (3), Neng Gouzhao
It is mapped to liquid mixer (9)；Sample cell I (9-2), sample cell II (9-3), microchannel I (9-4), microchannel II (9-5), mixing
Chamber (9-6), microchannel III (9-7) and liquid storage tank (9-8) are integrally machined forming and and glass slide by a monolith high molecular material piece
The upper surface of (9-1) fits closely, and one end of the microchannel I (9-4) and microchannel II (9-5) that are parallel to each other are respectively communicated with sample
Pond I (9-2) is connected to mixing chamber (9-6) with sample cell II (9-3), the other end, and mixing chamber (9-6) passes through microchannel III (9-7)
It is connected to liquid storage tank (9-8), microchannel III (9-7) is in U-shape in xy horizontal plane, and liquid when microchannel III (9-7) by forming
180 degree is curved, and microchannel III (9-7) is made of three microchannels for being divided into 1.5 millimeters；Sample cell I (9-2) and sample cell II
The upper surface of (9-3) all has the inlet that a diameter is 0.5 millimeter, and the inlet is sample cell I (9-2), sample cell II
(9-3), microchannel I (9-4), microchannel II (9-5), mixing chamber (9-6), microchannel III (9-7) and liquid storage tank (9-8) and big
The opening of gas connection；The depth of sample cell I (9-2), sample cell II (9-3) and liquid storage tank (9-8) are 250 microns, sample cell I
The volume of (9-2) and sample cell II (9-3) are 15 microlitres, and the volume of liquid storage tank (9-8) is 40 microlitres；Microchannel I (9-4) and
The length of microchannel II (9-5) is 10 millimeters, and the section of microchannel I (9-4) and microchannel II (9-5) are that height is 250
Micron, the rectangle that width is 70 microns；The depth of mixing chamber (9-6) is 70 microns, volume is 35 microlitres；Microchannel III (9-
7) section of three microchannels is that height is 250 microns, the rectangle that width is 50 microns.
Apparatus of the present invention have the miniflow body cavity and microchannel structure of special designing, using the mixing side based on centrifugal force
Method can be used in the mixing and reaction of small volume of fluid response sample.
Claims (5)
1. a kind of micro liquid mixed reactor, including computer (1), laser (2), lens group (3), camera (4), bottom
Seat (5), rotation motor (6), rotary shaft (7), revolving fragment (8), liquid mixer (9) and limited screw (10), xyz are three-dimensional sit
Mark system, liquid mixer (9) includes glass slide (9-1), sample cell I (9-2), sample cell II (9-3), microchannel I (9-4), micro-
Channel II (9-5), mixing chamber (9-6), microchannel III (9-7) and liquid storage tank (9-8), liquid mixer (9) have two sets；Laser
Device (2) and camera (4) are all connected with computer (1), and lens group (3) is located at before laser (2), laser (2), lens group
(3) and the position of camera (4) is adjustable, and rotation motor (6) is installed on pedestal (5) inside, and rotary shaft (7) is along the vertical side y
To, the lower end of rotary shaft (7) is connected to rotation motor (6), the top of pedestal (5) is exposed in upper end,
It is characterized in that: having the rectangle sheet metal of screw hole centered on revolving fragment (8), revolving fragment (8) is connected to rotation by screw hole
The upper end of shaft (7), and it is fixed by limited screw (10), and two sets of liquid mixers (9) are symmetrically installed on revolving fragment (8)
Above, rotation motor (6) is able to drive two sets of liquid mixers (9) in the horizontal rotation in surface of xy；Camera (4) is located at revolving fragment
(8) 15 centimeters above, and can be adjusted in collected optical signal transmission to computer (1) by computer (1)
The time response of the laser pulse of laser (2) transmitting is saved, after the laser of laser (2) transmitting passes through lens group (3), Neng Gouzhao
It is mapped to liquid mixer (9)；
Sample cell I (9-2), sample cell II (9-3), microchannel I (9-4), microchannel II (9-5), mixing chamber (9-6), microchannel
III (9-7) and liquid storage tank (9-8) are integrally machined forming and upper surface with glass slide (9-1) by a monolith high molecular material piece
It fits closely, one end of the microchannel I (9-4) and microchannel II (9-5) that are parallel to each other are respectively communicated with sample cell I (9-2) and sample
Product pond II (9-3), the other end are connected to mixing chamber (9-6), and mixing chamber (9-6) is connected to liquid storage tank by microchannel III (9-7)
(9-8), microchannel III (9-7) are in U-shape in xy horizontal plane, and microchannel III (9-7) is micro- logical by three that are divided into 1.5 millimeters
Road composition；The upper surface of sample cell I (9-2) and sample cell II (9-3) all have the inlet that a diameter is 0.5 millimeter, described
Inlet is sample cell I (9-2), sample cell II (9-3), microchannel I (9-4), microchannel II (9-5), mixing chamber (9-6), micro-
The opening that channel III (9-7) and liquid storage tank (9-8) are communicated with the atmosphere.
2. a kind of micro liquid mixed reactor as described in claim 1, it is characterized in that: sample cell I (9-2), sample cell
The depth of II (9-3) and liquid storage tank (9-8) is 250 microns, and the volume of sample cell I (9-2) and sample cell II (9-3) are 15
Microlitre, the volume of liquid storage tank (9-8) is 40 microlitres.
3. a kind of micro liquid mixed reactor as described in claim 1, it is characterized in that: microchannel I (9-4) and microchannel
The length of II (9-5) is 10 millimeters, and the section of microchannel I (9-4) and microchannel II (9-5) are highly for 250 microns, width
The rectangle that degree is 70 microns.
4. a kind of micro liquid mixed reactor as described in claim 1, it is characterized in that: the depth of mixing chamber (9-6) is
70 microns, volume be 35 microlitres.
5. a kind of micro liquid mixed reactor as described in claim 1, it is characterized in that: three of microchannel III (9-7)
The section of microchannel is that height is 250 microns, the rectangle that width is 50 microns.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910559209.4A CN110180465A (en) | 2019-06-18 | 2019-06-18 | A kind of micro liquid mixed reactor |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910559209.4A CN110180465A (en) | 2019-06-18 | 2019-06-18 | A kind of micro liquid mixed reactor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN110180465A true CN110180465A (en) | 2019-08-30 |
Family
ID=67723483
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910559209.4A Pending CN110180465A (en) | 2019-06-18 | 2019-06-18 | A kind of micro liquid mixed reactor |
Country Status (1)
| Country | Link |
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| CN (1) | CN110180465A (en) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020097632A1 (en) * | 2000-05-15 | 2002-07-25 | Kellogg Gregory J. | Bidirectional flow centrifugal microfluidic devices |
| KR20070044534A (en) * | 2005-10-25 | 2007-04-30 | 한국표준과학연구원 | Microfluidic mixer using multiple microchannel array and manufacturing method therefor |
| CN210522477U (en) * | 2019-06-18 | 2020-05-15 | 金华职业技术学院 | Micro-liquid mixing reaction device |
-
2019
- 2019-06-18 CN CN201910559209.4A patent/CN110180465A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020097632A1 (en) * | 2000-05-15 | 2002-07-25 | Kellogg Gregory J. | Bidirectional flow centrifugal microfluidic devices |
| KR20070044534A (en) * | 2005-10-25 | 2007-04-30 | 한국표준과학연구원 | Microfluidic mixer using multiple microchannel array and manufacturing method therefor |
| CN210522477U (en) * | 2019-06-18 | 2020-05-15 | 金华职业技术学院 | Micro-liquid mixing reaction device |
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