CN110180092A - A kind of online radiotherapy planning quality control system and its control method - Google Patents
A kind of online radiotherapy planning quality control system and its control method Download PDFInfo
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Abstract
This application involves a kind of online radiotherapy planning quality control system and its control method, the control system includes: data input/output module, adaptive planning module, delineates modifiers online；It and further comprise program evaluation index limits template setting module, program evaluation index reference value template setting module, radiotherapy planning evaluation index limit value setting module and radiotherapy planning evaluation index reference value setting module.Control system in the application can calculate the result of a variety of on-line tuning methods automatically simultaneously, and the structure of every kind of method of adjustment is evaluated, the recommendation of on-line tuning method is carried out according to evaluation result, whole process realizes automation substantially, doctor is only needed to confirm and modify to delineating, reduce the workload of doctor, so as to shorten the time, improves efficiency.
Description
Technical field
The invention belongs to medical radiotherapy field of quality control more particularly to a kind of online radiotherapy planning quality control systems
System and its control method.
Background technique
Radiotherapy is to treat an important technological means of tumour.A usual radiotherapy course for the treatment of can continue several weeks, at this
Tumour can usually generate displacement and deformation in the process, to influence the quality of radiotherapy.It is generated to control tumour displacement and deformation
Influence, obtain tumour displacement and deformation information clinically by the online mode for obtaining image, and then take corresponding online
Method of adjustment.
The mode for obtaining image in Patients During Radiotherapy online at present mainly has conical beam CT image (to add conical beam CT and radiotherapy
Fast device is integrated), fan-beam image (integrating fan-beam machine and radiotherapy accelerator) and magnetic resonance image be (by magnetic resonance equipment
It is integrated with radiotherapy accelerator).
Chinese patent (CN106055912B) discloses a kind of calculating of online image generation therapeutic bed adjustment data of basis
Machine system, when which carries out rigid registration by online image and raw video, targetedly setting is used for rigid registration
Region of interest and weight accurate pendulum position is carried out to patient, makes the reality of radiotherapy planning to generate more meaningful shifting bed data
It applies more acurrate.This field claims this on-line tuning method are as follows: moves bed.
Academic paper " A method to implement full six-degree target shift
Corrections for rigid body in image-guided radiotherapy " (Medical Physics, 33
(2006), p21-31) for general therapeutic bed it not can be carried out the activities of 6 freedom degrees, thus using rotary frame and collimator
The equivalent completion 6DOF adjustment of the mode of head.Because rack and collimator head rotating need to modify radiotherapy planning, we claim
This on-line tuning method are as follows: equivalent 6DOF moves bed combination Plan rescheduling.
Chinese patent (CN105825073B) discloses a kind of online radiotherapy planning quality control system, which includes
DVH early warning value template setting interface, data read in interface, radiotherapy planning DVH early warning value setting interface, delineate with melting interface,
Program Assessment interface, on-line tuning interface, anamorphose registration Algorithm, on-line planning modify algorithm, Dose calculation algorithm.This hair
It is bright to generate blending image by original image and in line image and describe target area and jeopardize delineating online for organ contours, it utilizes
It carries out Rapid Dose Calculation and generates DVH, and is compared with the DVH early warning value of doctor's setting, realizes commenting online for radiotherapy planning
Estimate and adjust, ensure that the accurate implementation of radiotherapy planning.But the radiotherapy planning quality control step in the invention is too cumbersome,
Considerably increase the time of radiation therapy delivery.
Academic paper " Gradient maintenance:A new algorithm for fast online
Replanning " (Medical Physics 42(2015) p2863-2876) provide a kind of dosage ladder with reference to original scheme
The method that degree carries out re-optimization.This field claims this on-line tuning method are as follows: on-line planning re-optimization.Likewise, because
Re-optimization method can modify radiotherapy planning, this can also greatly increase the time of radiation therapy delivery.
It is known in the art that sufferer situation is changeable, various and complicated during clinical radiation therapy implementing plan.It is above-mentioned each
The method proposed in document can not cover all radiotherapy on-line tuning methods.And various on-line tuning methods have it is respective
Feature, for example move bed process and implement simply, the time used is short；On-line planning re-optimization may obtain preferably plan, but need
It takes more time.Clinically, doctor also usually cracking can not judge that current case needs which kind of takes adjust online
Adjusting method.
Summary of the invention
In order to solve the above-mentioned technical problem.The present invention proposes a kind of supermatic online radiotherapy planning quality control system
System and its control method, using the radiotherapy planning quality control system, can calculate simultaneously a variety of on-line tuning methods as a result,
And every kind of method is evaluated, the recommendation of on-line tuning method is carried out according to evaluation result, reduces the work of user as far as possible
It measures, so as to shorten the time, improves efficiency.Specific technical solution is as follows.
A kind of online radiotherapy planning method of quality control, the control method the following steps are included:
Obtain original radiotherapy planning, it is original delineate, original image；
It obtains in line image；
Image registration will be carried out in line image and original image, and generate blending image and delineate online, set and counted according to user
The corresponding dosage distribution of different on-line tuning methods and evaluation index, and compare display；
User confirm it is described online delineate it is whether consistent with the profile in line image；If so, being then directly entered in next step；If not,
It is then modified by user to online delineate, so that it is accurately reflected the profile information in line image, and delineated online according to new
The corresponding dosage distribution of different on-line tuning methods and evaluation index are updated, and compares display；
User is according to the comparison display as a result, corresponding on-line tuning method is selected to carry out radiotherapy.
Preferably, the method also obtains original doses information.
Preferably, the evaluation index includes DVH evaluation index, conformal degree evaluation index, biological effect evaluation index.
Preferably, the comparison display can be replaced to the correspondence on-line tuning method and/or evaluation index for exceeding limit value
It is warned, and different on-line tuning methods is evaluated and recommended.
Preferably, user according to evaluation and recommend as a result, selection receive recommend on-line tuning method or selection it is other
On-line tuning method carry out radiotherapy.
Preferably, the limit value is the limit value of evaluation index.
A kind of online radiotherapy planning quality control system, the online radiotherapy planning quality control system can be realized as follows
Method of quality control:
Obtain original radiotherapy planning, it is original delineate, original image；
It obtains in line image；
Image registration will be carried out in line image and original image, and generate blending image and delineate online, set and counted according to user
The corresponding dosage distribution of different on-line tuning methods and evaluation index, and compare display；
User confirm it is described online delineate it is whether consistent with the profile in line image；If so, being then directly entered in next step；If not,
It is then modified by user to described delineate online, so that it is accurately reflected the profile information in line image, and put online by described
Treating plan quality control system, the corresponding dosage of the different on-line tuning methods of update is distributed and evaluation refers to according to new delineating online
Mark, and compare display；
User is according to the comparison display as a result, corresponding on-line tuning method is selected to carry out radiotherapy.
A kind of online radiotherapy planning quality control system, the system comprises: data input/output module, adaptive planning
Module delineates modifiers online.
Preferably, the system also includes program evaluation index limits template setting module and radiotherapy planning evaluation indexes
Limit value setting module.
Preferably, the system also includes: program evaluation index reference value template setting modules and radiotherapy planning evaluation to refer to
Mark reference value setting module.
Preferably, the program evaluation index limits template is according to the preset common template of tumor parameters；It is described
Each evaluation index limit value in radiotherapy planning evaluation index limit value setting module is the personalization for being directed to specific radiotherapy planning
The numerical value of setting, initial value are obtained by being automatically matched to corresponding program evaluation index limits template according to tumor parameters.
Preferably, the program evaluation index reference value template be according to the preset common template of tumor parameters, if
Determine evaluation index reference value and corresponding weight；
Each evaluation index reference value and weight in the radiotherapy planning evaluation index reference value setting module are then directed to tool
The radiotherapy planning of body, initial value are obtained by being automatically matched to corresponding program evaluation index reference value template according to tumor parameters
?.
Preferably, the evaluation index includes but is not limited to that DVH evaluation index, conformal degree evaluation index, biological effect are commented
Valence index.
Specifically, a kind of online radiotherapy planning method of quality control, the control method the following steps are included:
The data input/output module obtain original radiotherapy planning, it is original delineate, original image and original doses information；
The data input/output module is obtained in line image；
Adaptive planning module will carry out image registration in line image and original image, automatically generate and original image coverage area
Identical blending image and description target area and jeopardize delineating online for organ contours, according to different online of user's setup algorithm
The corresponding dosage distribution of method of adjustment and evaluation index, warn the correspondence on-line tuning method and index that exceed limit value,
And different on-line tuning methods is evaluated and recommended；
The user description target area that automatically generates of confirmation with whether jeopardize delineating for organ contours consistent with the profile in line image；Such as
It is then to be directly entered in next step；If not, making it using delineating modifiers online and modifying to organ contours by user
Online profile information is accurately reflected, adaptive planning module is distributed according to new profile information more new dosage and evaluation index,
Re-start evaluation and recommendation；
User receives the on-line tuning method recommended or other on-line tuning methods is selected to carry out radiotherapy.
A kind of online radiotherapy planning quality control system, the online radiotherapy planning quality control system realize following quality
Control method:
Obtain original radiotherapy planning, it is original delineate, original image and original doses information；
It obtains in line image；
Image registration will be carried out in line image and original image, and automatically generate blending image identical with original image coverage area
And description target area is delineated with the online of organ contours is jeopardized, according to user's setup algorithm, different on-line tuning methods is corresponding
Dosage distribution and evaluation index, to beyond limit value correspondence on-line tuning method and index warn, and to different online
Method of adjustment is evaluated and is recommended；
The user description target area that automatically generates of confirmation with whether jeopardize delineating for organ contours consistent with the profile in line image；Such as
It is then to be directly entered in next step；If not, being modified by user to organ contours, it is made to accurately reflect online profile letter
Breath, and re-started and commented according to new profile information update and evaluation index by the online radiotherapy planning quality control system
Valence and recommendation；
User receives the on-line tuning method recommended or other on-line tuning methods is selected to carry out radiotherapy.
Preferably, the different on-line tuning methods in the step 3) include online plan modification method and other are online
Method of adjustment；Wherein, other described on-line tuning methods including but not limited to move bed, equivalent 6DOF moves bed and combines plan tune
Whole, on-line planning re-optimization.
On-line planning modification method directly modifies original radiotherapy planning according to the displacement of tumour and deformation information, is not present
The process of re-optimization, and on-line planning re-optimization needs re-optimization radiotherapy planning.
Wherein, the new on-line planning modification method of one kind proposed by the present invention includes the following steps:
Image registration is carried out in line image and original image, corresponding three-dimensional is generated and deforms vector field；
According to the 3 D deformation vector field, will line image be generated as blending image identical with original image coverage area with
And description target area and the online of organ contours are delineated；The original is determined according to the 3 D deformation vector field in the region of interest of setting
The two dimension of transmitted intensity deforms vector field in each beam direction in beginning radiotherapy planning；
According to the two dimension deformation vector field of transmitted intensity in each beam direction to beam side corresponding in the original radiotherapy planning
Upward two-dimentional ray density distribution is deformed, and two-dimentional ray density distribution new in each beam direction is generated；
According to two-dimentional ray density distribution new in each beam direction, corresponding grating and tungsten door exercise data are generated,
Obtain new radiotherapy planning.
Preferably, the online radiotherapy planning quality control system is evaluated and is recommended to different on-line tuning methods
It is to be realized by on-line evaluation method, the on-line evaluation method specifically:
The index for indicating current on-line tuning effect is calculated according to multiple program evaluation indexs, specific formula is as follows:
Wherein, N is indicatedThe index number compared with original scheme is needed in calculating process；M is indicatedCalculating process
In plan target limit value in need of consideration number；I-th of evaluation index value after indicating on-line tuning；Table
Show i-th of evaluation index value in original radiotherapy planning；Indicate j-th of evaluation index limit value；It is norm operator；、Respectively represent i-th of weight relative to reference plan evaluation index respective items；、Respectively represent j-th of weight relative to program evaluation index limits respective items.
Work as evaluation index valueEffect is worse thanWhen, carry out first item
Calculating, not will do it Section 2Calculating.
Work as evaluation index valueEffect is better thanWhen, then it not will do it first item
Calculating, will do it Section 2Calculating.
Work as evaluation index valueEffect is worse thanWhen, it will do it first item
Calculating, not will do it Section 2Calculating.
Work as evaluation index valueEffect is better thanWhen, it not will do it first item
Calculating, will do it Section 2Calculating.
The system evaluates each on-line tuning method set by user according to above-mentioned on-line evaluation method respectively,
And handleIt is worth the smallest on-line tuning method and recommends user.
Alternatively, the on-line evaluation method can also be following steps, specifically:
The first step picks out the on-line tuning method for meeting evaluation index limit value, if the first step, which cannot be picked out, meets target appraisal
The plan of index limits, then without recommend, prompt all on-line tuning methods to be all unsatisfactory for target appraisal index limits, by with
It specifies on-line tuning method or stops treatment in family；
Second step is in the on-line tuning method for meeting evaluation index limit value, further according to on-line tuning method relative to original radiotherapy
The situation of change of program evaluation index is evaluated and is recommended.Wherein, on-line tuning method is commented relative to original radiotherapy planning
The formula that the situation of change of valence index is evaluated is as follows:
Wherein, N is indicatedThe index number compared with original scheme is needed in calculating process；Indicate on-line tuning
I-th of evaluation index value afterwards；Indicate i-th of evaluation index value in original radiotherapy planning；It is norm operator.
Work as evaluation index valueIt is worse thanWhen, it carries outSummation meter
It calculates；Work as evaluation index valueIt is better thanWhen, then this evaluation index is not involved in read group total.
The system comments all on-line tuning methods for meeting the first step according to above-mentioned on-line evaluation method respectively
Valence, and handleIt is worth the smallest on-line tuning method and recommends user.
Alternatively, the on-line evaluation method can also be following steps, specifically:
The first step picks out the on-line tuning method for meeting evaluation index limit value, if the first step, which cannot be picked out, meets target appraisal
The plan of index limits prompts all on-line tuning methods to be all unsatisfactory for evaluation index limit value, is referred to by user then without recommending
It is scheduled on line method of adjustment or stops treatment；
Second step is in the on-line tuning method for meeting evaluation index limit value, then according to on-line tuning method relative to radiotherapy planning
The situation that meets of evaluation index reference value is evaluated and is recommended.
Wherein, the public affairs for meeting situation and being evaluated to on-line tuning method relative to radiotherapy planning evaluation index reference value
Formula is as follows:
Wherein, N is indicatedThe index number compared with original scheme is needed in calculating process；Indicate on-line tuning
I-th of evaluation index value afterwards；Indicate i-th of evaluation index reference value；Represent i-th of evaluation index reference value pair
The weight answered.
IfIt is better than or meets, thenParticipate in summation operation；If otherwiseIt is worse than or is unsatisfactory for, thenIt is not involved in summation operation.
The system comments all on-line tuning methods for meeting the first step according to above-mentioned on-line evaluation method respectively
Valence, and handleIt is worth and maximum recommends user.
Third step, if obtained aboveBe worth maximum on-line tuning method more than one, then it is short according to the time is implemented
The small principle of risk, preferential recommendation move bed, secondly equivalent 6DOF are recommended to move bed combination Plan rescheduling, recommend online meter again
Draw amendment.
Control system in the application can calculate automatically simultaneously a variety of on-line tuning methods as a result, and being adjusted to every kind
The structure of method is evaluated, and the recommendation of on-line tuning method is carried out according to evaluation result, and whole process is realized completely certainly substantially
Dynamicization does not need manpower intervention, it is only necessary to which doctor confirms and modifies to delineating, and reduces the workload of doctor, to contract
Short time improves efficiency.
Specific embodiment
It below will the present invention is described in further detail by embodiment.Foregoing end other objects of the invention, spy
Sign, aspect and advantage will be apparent, and so that those skilled in the art can carry out according to the description.
It is understood that specific embodiment described herein is used only for explaining the present invention, rather than to of the invention
It limits.It is only to be not intended to be limiting the application merely for for the purpose of describing particular embodiments in term used in this application.At this
The "an" of application and singular used in the attached claims, " described " and "the" are also intended to including most shapes
Formula, unless the context clearly indicates other meaning.It is also understood that term "and/or" used herein refers to and includes
One or more associated any or all of project listed may combine.
Embodiment 1
A kind of online radiotherapy planning quality control system, the system comprises: data input/output module, adaptive planning mould
Block delineates modifiers online.
It includes: anamorphose method for registering that the online radiotherapy planning quality control system, which needs the method used, online
Method of adjustment, dose calculation methodology.
Wherein,
The data input/output module is responsible for the correspondence with foreign country of system.
The modifiers of delineating online can carry out online modification with organ contours are jeopardized to online target area.
Further, a kind of online radiotherapy planning method of quality control, the described method comprises the following steps:
1) data input/output module obtain original radiotherapy planning, it is original delineate, original image；
Wherein,
The original radiotherapy planning, original delineate can be putting for the image, formulation for treating preceding acquisition for the first time with original image
Treatment plan is delineated, and is also possible to the radiotherapy planning of a preceding radiotherapy, is delineated and image.
Preferably, the data input/output module can also obtain original doses information simultaneously.
2) data input/output module is obtained in line image；Wherein,
It is described to refer to the CT image for being able to reflect anatomical structure variation newly obtained, MR image, PET image or ultrasound figure in line image
Picture.
3) adaptive planning module will carry out image registration in line image and original image, automatically generate blending image and
It delineates online, according to the distribution of the different on-line tuning method of user's setup algorithm corresponding dosage, DVH and other evaluation indexes,
And compare display；
Image registration includes first latter two steps: the first step is to carry out image rigid registration in line image and original image；The
Two steps are to carry out anamorphose registration on the basis of the above.
Preferably, the coverage area for automatically generating blending image is identical as the coverage area of original image.
It is preferably, described that automatically generate the coverage area delineated online identical as the original coverage area delineated.
It automatically generates blending image identical with original image coverage area and description target area and jeopardizes organ contours
It delineates online；Rigid registration of the process of image registration by first carrying out and the two step structure of deformable registration on the basis of rigid registration result
At.Since original image usually has bigger scanning range, original image is often to the deformable registration in line image
Part, and rigid registration can then act on entire original image.Image registration the result is that a deformation vector
?.Deformation vector field in online image range is first rigid body redeformation registration generation, and the deformation outside online image range
Vector field is then that rigid registration generates.By deforming vector to the rigid registration for deforming vector field joining place with deformable registration
Field carries out interpolation processing, to make whole deformation vector field cover entire original image, and has certain continuity.To make to correspond to
Blending image there is coverage area identical with original image, image also keeps certain continuity.Similarly delineate online
Also have and delineate identical coverage area with original.
Preferably, the different on-line tuning method includes but is not limited to move bed, the shifting bed combination plan of equivalent 6DOF
Adjustment, on-line planning amendment, on-line planning re-optimization.
4) user confirmation automatically generate it is described online delineate it is whether consistent with the profile in line image；If so, then directly
Into in next step；If not, accurately reflecting it using delineating modifiers online and modifying to organ contours by user
The profile information of line, adaptive planning module is according to the distribution of new profile information more new dosage, DVH and other evaluation indexes, weight
Newly compare display；
5) user is according to the comparison display as a result, corresponding on-line tuning method is selected to carry out radiotherapy.
By embodiment it can be seen that step 1) 2) 3) it can be achieved to be fully automated, manpower intervention is not needed, only in step 4
It needs that online delineate is confirmed and modified, step 5 selects on-line tuning method.
Embodiment 2
On the basis of embodiment 1, in order to further increase the degree of automation of online radiotherapy planning quality control system, into one
Step saves doctor labour, and the present embodiment further carries out adaptive improvement to system, and place same as Example 1 is not superfluous
It states, it is specific as follows.
A kind of online radiotherapy planning quality control system, the system comprises: program evaluation index limits template sets mould
Block, radiotherapy planning evaluation index limit value setting module, adaptive planning module, delineates modification at data input/output module online
Tool.
It includes: anamorphose method for registering that the online radiotherapy planning quality control system, which needs the method used, online
Method of adjustment, dose calculation methodology, on-line evaluation method.
Wherein,
The program evaluation index limits template setting module is for setting program evaluation index limits template, the program evaluation
Index limits template is according to the preset common template such as tumor locus, type；The evaluation index includes but is not limited to
DVH evaluation index, conformal degree evaluation index (including but not limited to target area conformal degree index), biological effect evaluation index (including
But it is not limited to local control rate, normal organ complication probability).
It is worth noting that, DVH index is as the most important and most common evaluation index, in an embodiment of the present invention,
The evaluation index is selected as: DVH and other evaluation indexes.
The radiotherapy planning evaluation index limit value setting module is described for setting radiotherapy planning evaluation index limit value template
Each evaluation index limit value is directed to specific radiotherapy planning in radiotherapy planning evaluation index limit value template, and initial value is basis
Tumor locus, type are automatically matched to corresponding program evaluation index limits template and obtain.If user wishes to individual patient
The special evaluation index limit value of one setting then carries out adaptability in the radiotherapy planning evaluation index limit value setting module and repairs
Change.
The modifiers of delineating online can carry out online modification with organ contours are jeopardized to online target area.
The adaptive planning module can set according to user while show the DVH of a variety of on-line tuning methods and other
Evaluation index, and different on-line tuning methods is evaluated and recommended according to on-line evaluation method；And it can be according to online
Delineate that modifiers is modified to be delineated, update a variety of on-line tuning methods DVH and other evaluation indexes, re-start evaluation
And recommendation.
Further, a kind of online radiotherapy planning method of quality control, the described method comprises the following steps:
1) data input/output module obtain original radiotherapy planning, it is original delineate, original image；
Preferably, the data input/output module can also obtain original doses information simultaneously.
2) data input/output module is obtained in line image；
3) adaptive planning module will carry out image registration in line image and original image, automatically generate blending image and online
It delineates, according to the corresponding dosage distribution of the different on-line tuning method of user's setup algorithm, DVH and other evaluation indexes, to super
The correspondence on-line tuning method and index of limit value are warned out, and according to on-line evaluation method to different on-line tuning methods
It is evaluated and is recommended；
4) user confirm it is described online delineate it is whether consistent with the profile in line image；If so, being then directly entered in next step；Such as
It is no, then so that it is accurately reflected online profile information using delineating modifiers online and modifying to organ contours by user,
Adaptive planning module updates DVH and other evaluation indexes according to new profile information, re-starts evaluation and recommendation；
5) user receives the on-line tuning method recommended or other on-line tuning methods is selected to carry out radiotherapy.
Embodiment 3
On the basis of Examples 1 and 2, the present embodiment further limits on-line planning modification method.
The on-line planning modification method specifically includes:
(1) image registration is carried out in line image and original image, generates corresponding three-dimensional and deforms vector field；
(2) it according to the 3 D deformation vector field, will be generated as identical with original image coverage area merging figure in line image
Picture and description target area and the online of organ contours are delineated；
(3) each beam direction in the original radiotherapy planning is determined according to the 3 D deformation vector field in the region of interest of setting
The two dimension deformation vector field of upper transmitted intensity；Wherein,
The region of interest typically refers to target area, also may include and important jeopardizes organ.The region of interest of the setting refers to
User can specify which target area to generate ray in each beam direction with intraorganic 3 D deformation vector field is jeopardized using
The two dimension deformation vector field of intensity.
Usual user can specify only generates the deformation of transmitted intensity two dimension using the 3 D deformation vector field in the target area PTV
Vector field.If the amendment of plan influences organ important around tumour, such as spinal cord, user, which can specify, utilizes the target area PTV
With the 3 D deformation vector field in spinal cord, the two dimension deformation vector field of transmitted intensity in each beam direction is codetermined.True
It, can also be for not in the fixed original radiotherapy planning in each beam direction during the two dimension deformation vector field of transmitted intensity
Region of interest together (such as: the target area PTV is more important, and weight is set as 3；Spinal cord weight is set as that different weights 1) is arranged.
(4) according to the two dimension deformation vector field of transmitted intensity in each beam direction to corresponding in the original radiotherapy planning
Two-dimentional ray density distribution in beam direction is deformed, and two-dimentional ray density distribution new in each beam direction is generated；
(5) according to two-dimentional ray density distribution new in each beam direction, corresponding grating and tungsten door movement number are generated
According to get arrive new radiotherapy planning.
Embodiment 4
This embodiment proposes a kind of embodiment of online radiotherapy planning method of quality control, not with the something in common in embodiment 1
It gives and repeats or sketched.
A kind of online radiotherapy planning quality control system, the system realize a kind of online radiotherapy planning quality controlling party
Method the described method comprises the following steps:
1) radiotherapy apparatus control software automatically sends out patient-relevant informa while reading the original radiotherapy planning of current patents
Online radiotherapy planning quality control system is given, the system is according to the above- mentioned information received, simultaneously from the inquiry of DICOM server
Obtain original radiotherapy planning, it is original delineate, original image；
Preferably, the patient-relevant informa includes: patient's name, patient ID, original radiotherapy planning UID.
Preferably, the information that the system is inquired and obtained from DICOM server further includes original doses information.
It alternatively, can also be with while radiotherapy apparatus control software reads the original radiotherapy planning of current patents
Automatically entire original radiotherapy planning is sent to online radiotherapy planning quality control system, because original radiotherapy planning includes original
Beginning radiotherapy planning UID, reaches identical technical effect.
2) it is being got after line image in line image documentation equipment control software, the image that will acquire automatically passes through DICOM
Agreement is sent to online radiotherapy planning quality control system；
Preferably, the system realizes the inquiry and acquisition of data by data input/output module.It is online in the step 2
It further includes waiting centers that image documentation equipment, which controls software by the data that DICOM agreement is sent to online radiotherapy planning quality control system,
Data.
Alternatively, it is being got after line image in line image documentation equipment control software, the image hair that can be will acquire
It is sent to DICOM server, the UID of online image is only sent to online radiotherapy planning quality control system, then by online radiotherapy
Plan quality control system reads online image from DICOM server, reaches identical technical effect.Alternatively, online shadow
As equipment control software is being got after line image, the image that can be will acquire is sent to DICOM server, and puts online
It treats plan quality control system and detects whether DICOM server obtains new online image by way of constantly inquiring,
It was found that DICOM server obtains new after line image, this online image is read, identical technical effect is reached.Alternatively,
Online radiotherapy planning quality control system can be integrated into online image documentation equipment control software, in this way, online image documentation equipment control
Software can be directly used for online radiotherapy planning quality control system getting after line image, reach identical technical effect.
3) progress of adaptive planning module, which is registrated in line image with original image, is deformed vector field, according to deformation vector
Field automatically generates blending image and delineates online, according to the corresponding dosage point of the different on-line tuning method of user's setup algorithm
Cloth and DVH, and compare display；
4) whether what user's confirmation automatically generated delineates consistent with the profile in line image online；If so, being then directly entered next
Step；If not, making it accurately reflect online profile using modifiers is delineated online to delineating and modifying online by user
Information recalculates the corresponding dosage distribution of different on-line tuning methods, updates DVH, and comparison display again；
5) user receives the on-line tuning method recommended or other on-line tuning methods is selected to carry out radiotherapy.
By embodiment it can be seen that step 1) 2) 3) it can be achieved to be fully automated, manpower intervention is not needed, only in step 4
It needs that online delineate is confirmed and modified, step 5 selects on-line tuning method.
Embodiment 5
On the basis of embodiment 4, it is further proposed that a kind of embodiment of online radiotherapy planning method of quality control, with embodiment
It will not go into details or is sketched for something in common in 4.
A kind of online radiotherapy planning quality control system, the system realize a kind of online radiotherapy planning quality control stream
The step of journey, the process includes all steps in embodiment 4.
Further in 4 step 3) of embodiment, the coverage area for automatically generating blending image and original image cover
Lid range is identical, and described to automatically generate the coverage area delineated online identical as the original coverage area delineated.
It automatically generates blending image identical with original image coverage area and description target area and jeopardizes organ contours
It delineates online；Rigid registration of the process of image registration by first carrying out and the two step structure of deformable registration on the basis of rigid registration result
At.Since original image usually has bigger scanning range, original image is often to the deformable registration in line image
Part, and rigid registration can then act on entire original image.Image registration the result is that a deformation vector
?.Deformation vector field in online image range is first rigid body redeformation registration generation, and the deformation outside online image range
Vector field is then that rigid registration generates.By deforming vector to the rigid registration for deforming vector field joining place with deformable registration
Field carries out interpolation processing, to make whole deformation vector field cover entire original image, and has certain continuity.To make to correspond to
Blending image there is coverage area identical with original image, image also keeps certain continuity.Similarly delineate online
Also have and delineate identical coverage area with original.
Further in 4 step 4) of embodiment, delineated online according to modified, adaptive planning module is according to organ wheel
Wide transfer portion interpolation generates new deformation vector field, generates new blending image further according to new deformation vector field.
Embodiment 6
On the basis of embodiment 5, it is further proposed that a kind of embodiment of online radiotherapy planning method of quality control, with embodiment
It will not go into details or is sketched for something in common in 5.
A kind of online radiotherapy planning quality control system, the system realize a kind of online radiotherapy planning quality control stream
The step of journey, the process includes all steps in embodiment 5, and is commented in the comparison show dose distribution of its step 3) with other
On the basis of valence index, the correspondence on-line tuning method and index that exceed limit value are warned, and according to on-line evaluation method pair
Different on-line tuning methods are evaluated and are recommended；
Likewise, warning, the evaluation to different on-line tuning methods on the basis of 5 step 4) of embodiment to limit value is exceeded
It is all updated with recommendation；
5) user receives the on-line tuning method recommended or other on-line tuning methods is selected to carry out radiotherapy.
By embodiment it can be seen that step 1) 2) 3) it can be achieved to be fully automated, manpower intervention is not needed, only in step 4
It needs that online delineate is confirmed and modified, step 5 selects on-line tuning method.
Embodiment 7
It is further proposed that a kind of on-line evaluation side evaluated different on-line tuning methods on the basis of embodiment 1-7
Method.The on-line evaluation method meets situation according to the situation of change of original radiotherapy planning evaluation index and evaluation index limit value
To be evaluated and be recommended.
The evaluation method calculates the index for indicating current on-line tuning effect according to multiple program evaluation indexs。
Wherein, N is indicatedThe index number compared with original scheme is needed in calculating process；M is indicatedCalculating process
In plan target limit value in need of consideration number.
First sum formula is for evaluating variation feelings of the on-line tuning method relative to original radiotherapy planning evaluation index
Condition, second sum formula meet situation to evaluation index limit value for evaluating on-line tuning method.
I-th of evaluation index value after indicating on-line tuning.It indicates to comment for i-th in original radiotherapy planning
Valence index value.It is norm operator, L1 norm is taken in this embodiment, i.e.,Absolute value.
Work as evaluation index valueEffect is worse thanWhen, carry out first item
Calculating, not will do it Section 2Calculating.
Work as evaluation index valueEffect is better thanWhen, then it not will do it first item
Calculating, will do it Section 2Calculating.
、Respectively represent i-th of weight relative to reference plan evaluation index respective items.
It indicates j-th of evaluation index limit value, is inputted and determined by program evaluation index limits template setting module.Together
Sample, work as evaluation index valueEffect is worse thanWhen, it will do it first itemMeter
It calculates, not will do it Section 2Calculating.
Work as evaluation index valueEffect is better thanWhen, it not will do it first item
Calculating, will do it Section 2Calculating.
、Respectively represent j-th of weight relative to program evaluation index limits respective items.
It is worth noting that, above-mentioned " effect is poor " and " effect is good " is a relative concept.It is specific to each in system
" effect is poor " of evaluation index and " effect is good ", which has, clearly to be defined.Such as: for the V20 index for jeopardizing organ lung,
Be it is the smaller the better, if this indexIt comparesValue it is small, then mean dosage guideline valueEffect is better than；It is to be the bigger the better, if this index for the tumour D95% indexIt comparesValue it is big, then anticipate
Taste dosage guideline valueEffect is better than(in the case of D95% value is also greatly bad very much, it can be D95%'s
Bigger weight is given in upper limit index to consider).It is above-mentioned since the plan target in the application is not limited to dosage guideline
Only do example.Preferably, it is upper limit index that user, which can specify the index limits when setting index limits, in the present invention, or under
Limit index.If the index limits are upper limit index, then it represents thatNo more than this upper limit, illustrate that this index value is got over
It is small better；If the index limits are lower limit, then it represents thatIt cannot be below this lower limit, illustrate that this index value is got over
It is big better.User sets index in evaluation index limit value setting module and/or radiotherapy planning evaluation index limit value setting module
It has just been set and has finished when limit value.
Adaptive planning module evaluates on-line tuning method set by user according to above-mentioned on-line evaluation method, and
?It is worth the smallest on-line tuning method and recommends user.
Embodiment 8
On the basis of embodiment 1-7, the present embodiment is it is further proposed that another comments different on-line tuning methods
The on-line evaluation method of valence.On-line evaluation method is according to the situation of change and evaluation index limit value of original radiotherapy planning evaluation index
Meet situation to be evaluated and be recommended.
On-line evaluation method is divided into two steps, and the first step, which is picked out, to be met the on-line tuning method of evaluation index limit value and (select
Evaluation index value that on-line tuning method can be calculated by comparing and index limits are selected, such as: if index limitsFor upper limit index, then the evaluation index value no more than this limit value is selectedCorresponding on-line tuning method；If
Index limitsFor lower limit, then the evaluation index value not less than this limit value is selectedCorresponding online tune
Adjusting method), if the first step cannot pick out the plan for meeting target appraisal index limits, without recommend, prompt it is all
Line method of adjustment is all unsatisfactory for evaluation index limit value, specifies on-line tuning method by user or stops treating.Second step is meeting
Change in the on-line tuning method of evaluation index limit value, further according to on-line tuning method relative to original radiotherapy planning evaluation index
Change situation to be evaluated and recommended.Variation in the present embodiment to on-line tuning method relative to original radiotherapy planning evaluation index
The formula that situation is evaluated is as follows:
Wherein, N is indicatedThe index number compared with original scheme is needed in calculating process；Indicate on-line tuning
I-th of evaluation index value afterwards.Indicate i-th of evaluation index value in original radiotherapy planning.It is norm operator,
L1 norm is taken in this embodiment, i.e.,Absolute value.Work as evaluation index valueIt is worse thanWhen,
It carries outRead group total；Work as evaluation index valueIt is better thanWhen, then this
Evaluation index is not involved in read group total.
Adaptive planning module evaluates the on-line tuning method for meeting the first step according to above-mentioned on-line evaluation method,
And handleIt is worth the smallest on-line tuning method and recommends user.
Embodiment 9
On the basis of embodiment 1-8, the present embodiment further online radiotherapy planning quality control system is carried out it is perfect, specifically
Technical solution is as follows, and it will not go into details or is sketched for something in common.
A kind of online radiotherapy planning quality control system, the system comprises program evaluation index limits templates to set mould
Block, program evaluation index reference value template setting module, data input/output module, radiotherapy planning evaluation index limit value set mould
Block, adaptive planning module, delineates modifiers at radiotherapy planning evaluation index reference value setting module online.
It includes: anamorphose method for registering that the online radiotherapy planning quality control system, which needs the method used, online
Method of adjustment, dose calculation methodology, on-line evaluation method.
Wherein,
The program evaluation index reference value template is according to the preset common template such as tumor locus, type, and setting is commented
Valence index reference value and corresponding weight.The same evaluation index can set different reference value and weight, such as brain stem V54 small
Respective weights can be set as 5 when respective weights can be set as 1, V54 equal to 0 reference value when 5% reference value.
Each evaluation index reference value and weight in the radiotherapy planning evaluation index reference value setting module are then directed to
In specific radiotherapy planning, initial value is that corresponding program evaluation index reference is automatically matched to according to tumor locus, type
It is worth template to obtain.If user wishes that some sets special evaluation index reference value or weight to individual patient, at this
It modifies in radiotherapy planning evaluation index reference value setting module.
Embodiment 10
On the basis of embodiment 1-9, the present embodiment is it is further proposed that a kind of evaluate different on-line tuning methods
On-line evaluation method.
On-line evaluation method according to evaluation index limit value, evaluation index reference value meet situation and on-line tuning method is real
The small principle of time short risk is applied to be evaluated and be recommended.
On-line evaluation method is divided into three steps, and the first step, which is picked out, to be met the on-line tuning method of evaluation index limit value and (select
Evaluation index value that on-line tuning method can be calculated by comparing and index limits are selected, such as: if index limitsFor upper limit index, then the evaluation index value no more than this limit value is selectedCorresponding on-line tuning method；If
Index limitsFor lower limit, then the evaluation index value not less than this limit value is selectedCorresponding online tune
Adjusting method), if the first step cannot pick out the plan for meeting target appraisal index limits, without recommend, prompt it is all
Line method of adjustment is all unsatisfactory for evaluation index limit value, specifies on-line tuning method by user or stops treating.
Second step is in the on-line tuning method for meeting evaluation index limit value, then according to on-line tuning method relative to radiotherapy
The situation that meets of program evaluation index reference value is evaluated and is recommended.
The situation that meets in the present embodiment to on-line tuning method relative to radiotherapy planning evaluation index reference value is commented
The formula of valence is as follows:
Wherein,I-th of evaluation index value after indicating on-line tuning；Indicate i-th of evaluation index reference value；Represent the corresponding weight of i-th of evaluation index reference value.
IfIt is better than or meets, thenParticipate in summation operation；If otherwiseIt is worse than or is unsatisfactory for, thenIt is not involved in summation operation.
Adaptive planning module evaluates the on-line tuning method for meeting the first step according to above-mentioned on-line evaluation method,
And handleIt is worth and maximum recommends user.
Third step, if obtained aboveBe worth maximum on-line tuning method more than one, then it is short according to the time is implemented
The small principle of risk, preferential recommendation move bed, secondly equivalent 6DOF are recommended to move bed combination Plan rescheduling, recommend online meter again
Draw amendment.
Although the embodiments of the present invention have been disclosed as above, but its is not only in the description and the implementation listed
With it can be fully applied to various fields suitable for the present invention, for those skilled in the art, can be easily
Realize other modification, therefore without departing from the general concept defined in the claims and the equivalent scope, the present invention is simultaneously unlimited
In specific details.
Claims (9)
1. a kind of online radiotherapy planning method of quality control, which is characterized in that the control method the following steps are included:
1) obtain original radiotherapy planning, it is original delineate, original image；It obtains in line image；
2) image registration will be carried out in line image and original image, and will generate blending image and delineate online, is set according to user
The corresponding dosage distribution of different on-line tuning methods and evaluation index are calculated, and compares display；
3) user confirm it is described online delineate it is whether consistent with the profile in line image；If so, being then directly entered in next step；Such as
It is no, then it is modified by user to online delineate, so that it is accurately reflected the profile information in line image, and according to new online hook
The corresponding dosage distribution of the different on-line tuning methods of update and evaluation index are drawn, and compares display；
4) user is according to the comparison display as a result, corresponding on-line tuning method is selected to carry out radiotherapy.
2. a kind of online radiotherapy planning method of quality control according to claim 1, which is characterized in that the evaluation index
Including DVH evaluation index, conformal degree evaluation index, biological effect evaluation index.
3. a kind of online radiotherapy planning method of quality control according to claim 1, which is characterized in that the step 2,
The correspondence on-line tuning method and/or evaluation index for exceeding limit value can also be warned while comparing display in step 3)
Show, and different on-line tuning methods is evaluated and recommended.
4. a kind of online radiotherapy planning method of quality control according to claim 4, which is characterized in that user is according to evaluation
With recommendation as a result, selection receives the on-line tuning method recommended or other on-line tuning methods is selected to carry out radiotherapy.
5. a kind of online radiotherapy planning method of quality control according to claim 4, which is characterized in that the limit value is to comment
The limit value of valence index.
6. a kind of online radiotherapy planning quality control system, which is characterized in that the online radiotherapy planning quality control system energy
Enough realize following method of quality control:
1) obtain original radiotherapy planning, it is original delineate, original image；It obtains in line image；
2) image registration will be carried out in line image and original image, and will generate blending image and delineate online, is set according to user
The corresponding dosage distribution of different on-line tuning methods and evaluation index are calculated, and compares display；
3) user confirm it is described online delineate it is whether consistent with the profile in line image；If so, being then directly entered in next step；Such as
It is no, then it is modified by user to described delineate online, so that it is accurately reflected the profile information in line image, and by described online
Radiotherapy planning quality control system delineates the corresponding dosage distribution of the different on-line tuning methods of update and evaluation according to new online
Index, and compare display；
4) user is according to the comparison display as a result, corresponding on-line tuning method is selected to carry out radiotherapy.
7. a kind of online radiotherapy planning quality control system, which is characterized in that the system comprises: data input/output module,
Adaptive planning module delineates modifiers online.
8. a kind of online radiotherapy planning quality control system according to claim 8, which is characterized in that the system is also wrapped
It includes: program evaluation index limits template setting module and radiotherapy planning evaluation index limit value setting module.
9. a kind of online radiotherapy planning quality control system according to claim 9, which is characterized in that the system is also wrapped
It includes: program evaluation index reference value template setting module and radiotherapy planning evaluation index reference value setting module.
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