CN110179485A - A kind of method and apparatus for PET imaging system gain adjustment - Google Patents
A kind of method and apparatus for PET imaging system gain adjustment Download PDFInfo
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- 238000012879 PET imaging Methods 0.000 title claims abstract description 19
- 238000000034 method Methods 0.000 title claims abstract description 19
- 238000012636 positron electron tomography Methods 0.000 claims abstract description 36
- 238000001228 spectrum Methods 0.000 claims abstract description 18
- 238000003491 array Methods 0.000 claims abstract description 16
- 238000005259 measurement Methods 0.000 claims abstract description 14
- 230000005622 photoelectricity Effects 0.000 claims abstract description 8
- 239000013078 crystal Substances 0.000 claims description 9
- 230000005855 radiation Effects 0.000 claims description 3
- 230000003595 spectral effect Effects 0.000 claims description 2
- 238000001514 detection method Methods 0.000 abstract description 7
- 238000002059 diagnostic imaging Methods 0.000 abstract description 2
- 230000009286 beneficial effect Effects 0.000 description 3
- 230000007423 decrease Effects 0.000 description 3
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 2
- 238000002591 computed tomography Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 230000001965 increasing effect Effects 0.000 description 2
- 229910052710 silicon Inorganic materials 0.000 description 2
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- 239000003814 drug Substances 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 238000002372 labelling Methods 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 230000001052 transient effect Effects 0.000 description 1
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Abstract
The present invention provides a kind of method and apparatus for PET imaging system gain adjustment, it is related to medical imaging device technical field, the PET imaging system includes detector cells, and the method for gain adjustment includes: data acquisition: the single event for obtaining all channels in PET system counts；Energy spectrum obtains: obtaining the energy spectrum in each channel in PET system；Peak-seeking: the photopeak of each energy spectrum is obtained；Target peak obtains: counting target peak of the average value of the photoelectricity peak value of all channel actual measurements in all arrays as the PET system；Measurement peak value obtains: counting measurement peak value of the average value as the SiPM array of the photoelectricity peak value of all channel actual measurements in each array；Gain calibration table obtains: obtaining the gain calibration coefficient of each SiPM array；The input of gain calibration table；Power supply control: automatic slowly controls each SiPM array bias voltage to target bias.Guarantee the detection efficient consistency of each detector, realizes the promotion of PET image quality and performance indicator.
Description
Technical field
The invention belongs to medical imaging device technical fields, are related to a kind of method for PET imaging system gain adjustment
And device, in particular to it is based on SIPM-PET system detector module gain consistency calibration method.
Background technique
Positron Emission Computed Tomography (Positron Emission Computed Tomography, referred to as
It PET) is one of current state-of-the-art medical diagnostic equipment.Its working principle is that this is put by isotope labelling infusion of medicine body
Penetrating property nucleic can release positive electron, and annihilation radiation quickly occur with intracorporal negative electron, and two energy of generation are identical,
Contrary γ photon.
PET system by using the nuclear detector device around human body, available photon by detector detect when
Between, position and energy information, and according to the information reconstruction image.Common nuclear detector includes being made of multiple scintillation crystals
Crystal array (Crystal array) and photodetector.Wherein, crystal array is used to receive to release in patient
Photon (such as γ photon) simultaneously converts thereof into visible light, and photodetector is for it will be seen that light is converted into pulse signal.
SiPM (Silicon Photo-multiplier, silicon photomultiplier detector) is one gradually risen in recent years
Kind is used for the photoelectric detector in optical detection field, with traditional PMT (Photo multiplier tube, photomultiplier tube)
Compare, SiPM have it is small in size, convenient for being developed into the form of detector array；It can work, have good anti-under low bias
Magnetic interference and mechanical resistant impact property；With high-gain, high photon detection efficiency, quick response and excellent time point
The advantages that resolution and wide spectrum response range.And yield value and bias voltage provided by outside are linear, such as Fig. 1
It is shown.The disadvantage is that the gain inequality opposite sex of SiPM is larger, and when a SiPM pixels up to ten thousand constitute Solid-state pet detector system, detection
The detection efficient of detector is inconsistent at device system different location, to will cause the distortion or loss of original signal, causing can
Reliability decline, so that eventually leading to the decline of picture quality and performance indicator.
The principle of pet detector based on SIPM is the high energy Gamma light for being captured detector crystal module using SiPM
The low energy visible light signal that son is converted to is converted into electric signal by photoelectric effect, and amplifies, and can be usually reached 106 increasings
Beneficial rank, then analog signal processing is carried out by electronics module and is converted into digital signal, then carries out signal output and place
Reason.
PET system is usually made of hundreds and thousands of a SiPM arrays, each SiPM array by: M*N SiPM pixel forms
(M, N are greater than 1).Due to the inconsistency of SiPM own gain, and the same SiPM array uses the same bias voltage,
This may can be excessively high due to the gain of certain SiPM pixels, lead to the distortion of pulse signal, and the gain of certain SiPM pixels
Too low, pulse signal cannot be received.To will lead to the counting inconsistency of PET system, the final figure for influencing PET system
Image quality amount and performance indicator.
Therefore, how to realize that the gain consistency of each SiPM array in PET system will become most important, this will affect
The performance indicator and picture quality of PET system.
In the prior art, there is following two to the gain process mode of SiPM array:
1, all SiPM arrays in entire PET system use the same bias voltage, and SiPM arrays all at this time is protected
Hold that original yield value is constant, the SiPM array gain that will lead to complete machine PET system is uneven.Because of high-gain at this time
SiPM array, yield value keep higher；The SiPM array of low gain, yield value keep relatively low.Therefore, it will lead to gain
It is worth higher SiPM array, signal is possible to be distorted, and the relatively low SiPM array of yield value, signal is possible to lose, finally
Lead to the decline of picture quality and performance indicator.
2, the bias voltage adjustment mode of all SiPM arrays is used and is manually adjusted；The disadvantage is that: consumption manpower, and hand
Dynamic adjustment, may lead to device damage due to transient voltage, meanwhile, it manually adjusts, without reference to benchmark, also results in tune
Whole unevenness.
Based on this, in digital PET system, there is an urgent need to a kind of adaptive SiPM array gain adjust automatically skills
Thus art, Lai Tisheng picture quality and system performance index, this case generate.
Summary of the invention
In order to solve drawbacks described above existing in the prior art, the present invention is a kind of for PET imaging system gain adjustment
Method and apparatus, so that SiPM array gain adjust automatically, to promote picture quality and system performance index.
To achieve the goals above, the technical solution adopted by the present invention is as follows:
A method of for PET imaging system gain adjustment, the PET imaging system includes detector cells, gain
The method of adjustment includes:
Data acquisition: the single event for obtaining all channels in PET system based on background radiation or outer rays source counts；
Energy spectrum obtains: obtaining the energy spectrum in each channel in PET system；
Peak-seeking: the photopeak of each energy spectrum is obtained；
Target peak obtains: counting the average value E of the photoelectricity peak value of all channel actual measurements in all arraysave, as
The target peak E of the PET systemtarget, Etarget=Eave；
Measurement peak value obtains: counting the average value of the photoelectricity peak value of all channel actual measurements in each array
Earray-ave, measurement peak E as the SiPM arraymeasure, Emeasure=Earray-ave；
Gain calibration table obtains: will measure peak EmeasureWith target peak EtargetIt makes comparisons, obtains each SiPM array
Gain calibration coefficient δi, using following formula:
Wherein, i=1,2,3 ... ... N, N are the SiPM number of arrays of PET system；
The input of gain calibration table；
Power supply control: according to the gain calibration coefficient of each SiPM array, automatic slowly controls each SiPM array bias voltage
To target bias.
Further, in the energy spectrum obtaining step, the energy-count distribution curve in each channel is obtained as energy
Spectrum.
Further, in the peak-seeking step, Gauss curve fitting is carried out to the energy spectral curve in each channel, and find
511keV photoelectricity peak position.
Further, in the gain calibration table obtaining step, the corresponding gain calibration of all SiPM arrays of PET system
The collection of coefficient is combined into the gain calibration table of the PET system.
Further, in the step of power supply controls, for the SiPM array of high gain, bias voltage is slowly lowered；
The SiPM array low for gain, slow boost bias voltage.
Further, the detector cells include scintillation crystal array, SiPM array, module ASIC, FPGA module and
Energy supply control module；The module ASIC, for obtaining corresponding position and energy information；The FPGA module, for increasing
The lookup of beneficial table, and corresponding gain calibration coefficient is sent to energy supply control module.
A kind of device for PET imaging system gain adjustment, comprising:
Unit for data acquisition；The unit obtained for energy spectrum；Unit for peak-seeking；For target peak
The unit of acquisition；For measuring the unit of peak value acquisition；The unit obtained for gain calibration table；List for power supply control
Member.
Beneficial effects of the present invention and principle:
(1) present invention is the gain calibration coefficient by obtaining each SiPM array in detector system, and according to gain school
Quasi- coefficient adjust automatically corresponds to the bias voltage of SiPM array, realizes the gain one of all SiPM arrays in digital PET system
The adjustment of cause property.To guarantee the detection efficient consistency of each detector, and finally realize PET image quality and performance indicator
It is promoted.
(2) the different SiPM array of the present invention, according to the difference of its yield value, using different bias voltages.
(3) adjustment of bias voltage of the present invention, is adjusted using automatic slowly, and SiPM is avoided to be led to device by moment impact
Damage.
(4) in the entire PET detection system of the present invention, the yield value of all SiPM arrays reaches unanimity, so that detector is read
Data are truer out, effectively.
(5) present invention improves the quality of pulse signal, finally realizes the promotion to picture quality and performance indicator.
Detailed description of the invention
Fig. 1 is the relation curve of gain and bias voltage；
Fig. 2 is the module frame chart of PET imaging system of the present invention；
Fig. 3 is the module frame chart of pet detector unit of the present invention；
Fig. 4 is a kind of flow chart/module frame chart of the method for PET imaging system gain adjustment of the present invention；
Fig. 5 is the present embodiment energy-count curve distribution map；
Fig. 6 is energy-count distribution figure after the present embodiment Gauss curve fitting.
Specific embodiment
In order to make the attainable technical effect of technological means of the invention and its institute, more perfect disclosure can be become apparent from,
Following embodiment is hereby provided, and is described in detail as follows in conjunction with attached drawing:
Signified each channel of the invention refers to each SiPM pixel.
The present embodiment PET system is made of 2 detector rings A, B, A, B detector rings circumferencial direction respectively by: 38
Detector module composition, each detector module are made of 2 × 3 crystal+SiPM arrays, and each SiPM array is by 8x 8
SiPM pixel composition.I.e. the present embodiment PET system is altogether by 76 detector module/456 array/29184 crystal+SiPM
SiPM pixel composition.
The acquisition of S1 data: data acquisition uses outer rays source, and Na22 radiographic source is placed in the central region position of detector rings
It sets, acquisition time 5min.
S2 energy spectrum obtains: after the completion of data acquisition, starting to analyze the collected single event of institute, obtains each pixel
Energy spectrum, it may be assumed that the distribution of energy-count curve.29184 SiPM pixels are shared in the present embodiment, that is, there are 29184 energy-
Count curve distribution map, energy-count curve distribution map (as shown in Figure 5).
S3 peak-seeking: photopeak lookup is carried out to energy-count distribution curve of 29184 SiPM pixels all in system.
Using Gauss curve fitting, and the corresponding energy value of peak value (Epeak, abscissa value) for calculating all pixels；Energy after Gauss curve fitting
Amount-count distribution is as shown in Figure 6.
S4 target peak obtains: the Epeak of the peak value of all SiPM pixels (totally 29184) being averaged, that is, is somebody's turn to do
The target peak of PET system, it may be assumed that
Wherein, num=29184, EtargetFor the target peak of PET system；
S5 measures peak value and obtains: the acquisition of each SiPM array measurement peak value, by 8x8 SiPM pixel of identical array
Energy-count curve peak value Epeak be averaged, that is, obtain the measurement peak value of the SiPM array,
That is:
Wherein, n=64, i=1,2,3 ... ... N, N are PET system SiPM number of arrays, it may be assumed that N=456；
The acquisition of S6 gain calibration table: gain calibration table is the set of gain calibration coefficient.The gain school of each SiPM array
Quasi- coefficient δiIt is calculated as follows:
Wherein, i=1,2,3 ... ... N, N are PET system SiPM number of arrays, it may be assumed that N=456；
The control of S7 power supply: the gain calibration value fed back according to gain calibration table does the bias voltage of each SiPM array
Adjustment.Work as δiWhen > 1, the bias voltage (Vbias) of corresponding SiPM array is slowly incremented to Vbias* δi?；Work as δiWhen < 1,
The bias voltage (Vbias) of corresponding SiPM array is slowly decremented to Vbias* δi, work as δiWhen=1, then keep current inclined
It is constant to set voltage.
The above content is combine the preferred embodiment of the present invention to made by provided technical solution further specifically
It is bright, and it cannot be said that the present invention specific implementation be confined to it is above-mentioned these explanation, for the common skill of the technical field of the invention
For art personnel, without departing from the inventive concept of the premise, a number of simple deductions or replacements can also be made, should all regard
To belong to the scope of protection of the present invention.
Claims (7)
1. a kind of method for PET imaging system gain adjustment, the PET imaging system includes detector cells, gain tune
Whole method includes:
Data acquisition: the single event for obtaining all channels in PET system based on background radiation or outer rays source counts；
Energy spectrum obtains: obtaining the energy spectrum in each channel in PET system；
Peak-seeking: the photopeak of each energy spectrum is obtained；
Target peak obtains: counting the average value E of the photoelectricity peak value of all channel actual measurements in all arraysave, as this
The target peak E of PET systemtarget, Etarget=Eave；
Measurement peak value obtains: counting the average value E of the photoelectricity peak value of all channel actual measurements in each arrayarray-ave, as
The measurement peak E of the SiPM arraymeasure, Emeasure=array-ave；
Gain calibration table obtains: will measure peak EmeasureWith target peak EtargetIt makes comparisons, obtains the gain of each SiPM array
Calibration factor δi, using following formula:
Wherein, i=1,2,3 ... ... N, N are the SiPM number of arrays of PET system；
The input of gain calibration table；
Power supply control: according to the gain calibration coefficient of each SiPM array, automatic slowly controls each SiPM array bias voltage to mesh
Mark bias.
2. a kind of method for PET imaging system gain adjustment as described in claim 1, wherein the energy spectrum obtains
In step, the energy-count distribution curve in each channel is obtained as energy spectrum.
3. a kind of method for PET imaging system gain adjustment as claimed in claim 2, wherein in the peak-seeking step,
Gauss curve fitting is carried out to the energy spectral curve in each channel, and finds 511keV photoelectricity peak position.
4. a kind of method for PET imaging system gain adjustment as described in claim 1, wherein the gain calibration table
In obtaining step, the collection of the corresponding gain calibration coefficient of all SiPM arrays of PET system is combined into the gain calibration of the PET system
Table.
5. a kind of method for PET imaging system gain adjustment as described in claim 1, wherein the power supply control
In step, for the SiPM array of high gain, bias voltage is slowly lowered；The SiPM array low for gain slowly rises inclined
Set voltage.
6. a kind of method for PET imaging system gain adjustment as described in claim 1, wherein the detector cells
Including scintillation crystal array, SiPM array, module ASIC, FPGA module and energy supply control module；The module ASIC, for obtaining
Take corresponding position and energy information；The FPGA module, for the lookup to gain table, and will corresponding gain calibration coefficient hair
Give energy supply control module.
7. a kind of device for PET imaging system gain adjustment, comprising:
Unit for data acquisition；
The unit obtained for energy spectrum；
Unit for peak-seeking；
The unit obtained for target peak；
For measuring the unit of peak value acquisition；
The unit obtained for gain calibration table；
Unit for power supply control.
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Cited By (7)
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| CN111568453A (en) * | 2020-05-25 | 2020-08-25 | 上海联影医疗科技有限公司 | Energy correction state detection method, energy correction state detection device, computer equipment and storage medium |
| CN111736207A (en) * | 2020-05-28 | 2020-10-02 | 广东明峰医疗科技有限公司 | PET time calibration method |
| CN112353411A (en) * | 2020-11-10 | 2021-02-12 | 明峰医疗系统股份有限公司 | SIPM temperature drift self-adaptive system and compensation method |
| CN112882081A (en) * | 2021-01-13 | 2021-06-01 | 明峰医疗系统股份有限公司 | PET detector full-channel gain calibration method |
| CN113133776A (en) * | 2020-01-17 | 2021-07-20 | 上海联影医疗科技股份有限公司 | Multi-modal information calibration method and device and multi-modal imaging equipment |
| WO2021238929A1 (en) * | 2020-05-25 | 2021-12-02 | 上海联影医疗科技股份有限公司 | State detection method and system for imaging device |
| WO2022257014A1 (en) * | 2021-06-08 | 2022-12-15 | 中加健康工程研究院(合肥)有限公司 | Method and apparatus for displaying crystal efficiency of pet device, electronic device, and medium |
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| CN113133776A (en) * | 2020-01-17 | 2021-07-20 | 上海联影医疗科技股份有限公司 | Multi-modal information calibration method and device and multi-modal imaging equipment |
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| WO2022257014A1 (en) * | 2021-06-08 | 2022-12-15 | 中加健康工程研究院(合肥)有限公司 | Method and apparatus for displaying crystal efficiency of pet device, electronic device, and medium |
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