CN110170074A - A kind of calcium citrate/polylactic acid bone renovating material of melt-blending process preparation and its application - Google Patents
A kind of calcium citrate/polylactic acid bone renovating material of melt-blending process preparation and its application Download PDFInfo
- Publication number
- CN110170074A CN110170074A CN201910530080.4A CN201910530080A CN110170074A CN 110170074 A CN110170074 A CN 110170074A CN 201910530080 A CN201910530080 A CN 201910530080A CN 110170074 A CN110170074 A CN 110170074A
- Authority
- CN
- China
- Prior art keywords
- polylactic acid
- calcium citrate
- melt
- bone
- blending process
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
- A61L2300/102—Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
Abstract
The invention belongs to bone injuries to repair field of medical materials, and in particular to a kind of calcium citrate/polylactic acid bone renovating material of melt-blending process preparation and its application.The present invention provides a kind of calcium citrate/polylactic acid bone renovating material of melt-blending process preparation, due to calcium citrate and the good compatibility of polylactic acid, evenly dispersed composite material can be formed, and there is good mechanical property and moulding processability, the two recombination energy embodies good biocompatibility simultaneously, biodegradable, and in degradation process, calcium citrate degradation slight alkali environment can offset polylactic acid and individually degrade brought acidic environment, there is provided a stabilization suitable calcium ion environment, create local high calcium environment, to promote the growth of freshman bone tissue.There is good processability by calcium citrate/polylactic acid bone renovating material prepared by melt-blending process simultaneously, it is easy to process at size, shape needed for clinical application, it can be used for being processed into and fix required bone plate, bone screws, Invasive lumbar fusion device etc. in orthopaedics.Calcium citrate of the invention/polylactic acid bone composite material can also regulate and control the degradation speed of composite material by adjusting polylactic acid molecule amount, repair needs to meet the bone injury of different healing times.
Description
Technical field
The present invention relates to a kind of calcium citrate/polylactic acid bone renovating material of melt-blending process preparation and its applications, belong to
Bone injury repairs biomedical materials field.
Background technique
With the development of science and technology medical level is being continuously improved, medical material is more and more widely paid attention to, wherein
The research emphasis repaired using artificial bone substitute materials, substitute bone defect as Medical orthopaedic field, and treatment is due to tight
Inflict heavy losses on the effective means of the orthopaedic diseases such as wound, birth defect, bone tumour, osteomyelitis.Ideal bone renovating material should have well
Matrix adaptability, that is, biocompatibility, there is suitable mechanical property, while there is good self-bone grafting, conductive performance, energy
Promote the growth of freshman bone tissue, the formation of induced osteogenesis cell will also have good processability, easy to process at required
Size, shape.
Due to the easy plastotype of polylactic acid, and there is good biocompatibility and degradability, polylactic acid and inorganic calcium salt
Compound bone renovating material has been widely used in treating bone injury.Nowadays compound using more calcium salt component and polylactic acid
There are hydroxyapatite, tricalcium phosphate, calcium monohydrogen phosphate etc..Chinese patent 200710032725.9 discloses a kind of for bone plate, bone
It follows closely, the preparation method of the material of bone block, Biomedical Fiber, hydroxyapatite, polylactic acid, compatilizer will be placed in double by this method
Melt blending in screw extruder or torque rheometer；Or by polylactic acid and with polylactic acid macromonomer be grafted hydroxyl phosphorus
Lime stone is dissolved in chloroform, and addition Biomedical Fiber is evenly dispersed, is dried in vacuo after chloroform volatilization and film is made, prepare
For the polylactic acid/hydroxy apatites material such as bone plate, bone nail, bone block.But hydroxylapatite biology degradability is poor, and brittleness is big,
Part offer calcium ion concentration is inadequate, cannot guide well and limit it the problems such as New born formation in biomedical materials field
Application.Chinese invention 201610607512.3 discloses a kind of polylactic acid/nano bata-tricalcium phosphate composite material and its preparation
Method, this method will pass through ball milling, molding hot-working, complex process, and bata-tricalcium phosphate is compared with calcium citrate
The defects of activity is inadequate, and preparation method forming ability is limited also limits its application range clinically.Due to hydroxy-apatite
Stone, tricalcium phosphate etc. belong to inorganic calcium salt component, surface hydrophilic and hate oil, this characteristic with polymer substrate on the contrary,
This species diversity easily causes that the interface compatibility of particle and polymer is poor, leads to that combination interface is unstable, particle dispersing uniformity is poor
And it is easy to reunite.Suchlike problem and shortage just needs to study new direction, provides to further realize clinical treatment application
New idea and method.
Calcium citrate is a kind of organic calcium salt, and the calcium ion concentration of saturated solution is 5.14mmol/L, with can conducive at
The calcium ion concentration of bone cell proliferation differentiation is adapted, and is a kind of material that preferably can be used for Bone Defect Repari.Calcium citrate can be
Degrade and be absorbed in vivo, and the change human body fluid pH value that is not obvious in absorption process of degrading, degradation process discharge calcium from
Son is also very steady efficient, is conducive to effective absorb.Logical control synthesizing citric acid calcium (Chinese patent before this seminar
201410061265.2；201410612150.8；201410612039.9；201410612989.1), make the form of calcium citrate
Feature and degradation characteristic are regulated, and convenient for compound to be applied in Bone Defect Repari field, and have been applied in inorganic system
It embodies.For example, Li et al. is in Preparation and properties of calcium citrate nanosheets for
bone graft substitute (Li J, Liu Y, Gao Y, et al. Preparation and properties
of calcium citrate nanosheets for bone graft substitute [J]. Bioengineered,
2016,7 (5): 376-381.) in propose a kind of method synthesis nano sheet calcium citrate easily and effectively, and study
Application of the calcium citrate as bone renovating material.Subsequent cell and animal experiments show that, calcium citrate can promote newly
The formation of bone.Chinese invention 201511008235.6 provides a kind of bone cement and preparation method thereof containing calcium citrate, the hair
The bone cement containing calcium citrate of bright offer has good bone guided and bone-inducting active, but there are still certain defect, than
If mechanical property is poor, forming ability is limited etc..
By being studied above it was found that working as calcium citrate separately as bone renovating material application, degradation speed is too fast, long
Phase curative effect is not significant etc., and the problem of can not avoiding, is not well solved yet at present.Calcium citrate with inorganic system is compound also deposits
In poor mechanical property, and the problems such as can not match with internal degradation speed.
The present invention, which uses, has excellent biocompatibility, biological degradability and certain mechanical property and molding processibility
Can, it has been widely used as the polylactic acid of bone defect healing and bone fracture internal fixation material, has been melted with organic calcium salt calcium citrate
It is blended, prepares calcium citrate/polylactic acid bone renovating material.On the one hand, since calcium citrate is organic calcium salt, have one with macromolecule
A good compatibility is different from situations such as tricalcium phosphate or hydroxyapatite are bad with macromolecule compatibility, can be with polylactic acid
Homogeneous blend dispersion prepares composite material without modification, embodies good interface affinity, has good
Mechanical property and moulding processability, while being degraded based on the coordination of polylactic acid matrix, it can solve common citric acid calcium powder drop
Solve it is too fast, the problem of can not reaching an agreement with the new bone formation time.On the other hand, polylactic acid is degraded from degradation process
Product slant acidity is easy to cause inflammation in vivo, to limit its application to a certain extent.And calcium citrate degradation environment is then
Opposite meta-alkalescence may achieve a well suitable tunable degradation environment based on polylactic acid on this basis, can be with polylactic acid
Slant acidity environment caused by degrading is cancelled out each other, and the ionic microenvironments of Bone Defect Repari preferably are provided.
Calcium citrate/polylactic acid bone renovating material of melt-blending process preparation provided by the invention has good plastic type
Property and mechanical property, it is biodegradable, and calcium ion can be steadily discharged in degradation process.There is good biofacies simultaneously
Capacitive, no biotoxicity, good osteoconductive and osteoinductive.Calcium citrate prepared by the present invention/polylactic acid Composite Bone is repaired
Multiple material, can be used for being processed into and fixes required bone plate, bone screws, Invasive lumbar fusion device etc. in orthopaedics, on the other hand can pass through
Polylactic acid molecule amount is adjusted to regulate and control the degradation speed of composite material, repairs need to meet the bone injury of different healing times
It wants, provides a kind of feasible effective new bone renovating material for bone renovating material field.
Summary of the invention
The present invention is directed to the deficiency of existing bone defect healing field composite material, provides a kind of lemon of melt-blending process preparation
Lemon acid calcium/polylactic acid bone renovating material.The composite material is made of polylactic acid and calcium citrate, and calcium citrate is four citrate hydrates
Sour calcium, polylactic acid molecule amount are 10 ~ 200,000.By percentage to the quality, calcium citrate content is 1 ~ 30%, remaining contains for polylactic acid
Amount.Tensile strength is 14 ~ 29Mpa, and elasticity modulus is 449 ~ 683MPa, and contact angle is 57 ~ 75 °.
Calcium citrate/polylactic acid bone renovating material preparation method of melt-blending process preparation of the present invention, specifically
Steps are as follows:
(1) polylactic acid and calcium citrate of corresponding proportion are weighed with electronic balance；
(2) load weighted polylactic acid and calcium citrate are subjected to melt blending at 150 ~ 180 DEG C, melt blending includes will be newborn
Acid and the common melt blending of calcium citrate, or polylactic acid is first melt into fluidised form adds calcium citrate and be blended；
(3) by stirring to get finely dispersed mixture；Speed of agitator is 100 ~ 300r/min；
(4) it injects the mixture into mold, cooled to room temperature obtains calcium citrate/polylactic acid of melt-blending process preparation
Bone renovating material.
The invention has the benefit that
The present invention provides a kind of calcium citrate/polylactic acid bone renovating material of melt-blending process preparation.The compound system can solve
Certainly inorganic calcium salt and the problem that polylactic acid compatibility is not good enough and degradation is slower, it is too fast also to can solve the degradation of calcium citrate powder
And the problem of can not reaching an agreement with the new bone formation time, and calcium citrate degrade the weakly alkaline environment to be formed can neutralize it is poly-
Lactic acid is degraded the weak acid environment to be formed, and the microenvironment of bone tissue reparation preferably is provided.Since calcium citrate and polylactic acid are good
Good compatibility, which makes the two not have to modification, can well be mixed to form evenly dispersed composite material, and have good mechanical property
Energy and moulding processability, while the two recombination energy embodies good biocompatibility, and in the long period of Bone Defect Repari
It is interior to provide a stabilization suitable calcium ion environment with material degradation, local high calcium environment is created, to promote freshman bone tissue
Growth, the formation of induced osteogenesis cell show self-bone grafting and osteoconductive energy.
Therefore, calcium citrate/polylactic acid bone renovating material of a kind of melt-blending process preparation provided by the invention, mechanical property
Can be good with moulding processability, Bone Defect Repari effect is good, and complex effect is obvious, can also be by adjusting polylactic acid molecule amount and answering
Composition and division in a proportion example come regulate and control the degradation speed of composite material with meet the bone injury of different healing times repair needs, can be used for processing
At fixing required bone plate, bone screws, Invasive lumbar fusion device etc. in orthopaedics.
Detailed description of the invention:
Fig. 1 is calcium citrate/polylactic acid bone renovating material XRD diagram of 1 melt-blending process of embodiment of the present invention preparation；
Fig. 2 is calcium citrate/polylactic acid bone renovating material SEM figure of 1 melt-blending process of embodiment of the present invention preparation；
Fig. 3 is that calcium citrate/polylactic acid bone renovating material of 1 melt-blending process of embodiment of the present invention preparation is tried by biomineralization
SEM figure after testing 7 days；
Fig. 4 is 4 calcium citrates of the embodiment of the present invention/polylactic acid composite bone repairing material contact angle photo；
Fig. 5 be the embodiment of the present invention 1 ~ 4 melt-blending process prepare calcium citrate/polylactic acid bone renovating material be immersed in pH=
Degradation situation map in 7.4 PBS phosphate buffer solution.
Specific embodiment:
Below in conjunction with specific embodiment, invention is further described in detail, but protection scope of the present invention is not limited to
The content.
Embodiment 1:
Calcium citrate/polylactic acid bone renovating material of melt-blending process preparation provided in this embodiment is by polylactic acid and calcium citrate
Composition, by percentage to the quality, the content of calcium citrate are 20%, remaining is polylactic acid；Calcium citrate is four citric acid monohydrates
Calcium, the molecular weight of polylactic acid are 200,000.Specific implementation step is as follows:
(1) 8 grams of polylactic acid and 2 grams of calcium citrate are weighed with electronic balance；
(2) load weighted polylactic acid and calcium citrate are subjected at 180 DEG C melt blending, are uniformly dispersed by stirring to get
Mixture；Mixing speed is 200r/min；
(3) it injects the mixture into template, after 3min cooled to room temperature, prepares the citric acid of melt blending preparation
Calcium/polylactic acid bone renovating material.
Fig. 1 is calcium citrate/polylactic acid bone renovating material XRD spectra of melt-blending process preparation in this example.
Fig. 2 is calcium citrate/polylactic acid bone renovating material SEM figure of melt-blending process preparation in embodiment.
Calcium citrate/polylactic acid bone renovating material stretching of melt-blending process preparation is measured using omnipotent test machine for mechanism
Intensity is 16.834MPa, elasticity modulus 611.126MPa
Calcium citrate/polylactic acid bone renovating material water that in this example prepared by melt-blending process is measured by contact angle measurement
Contact angle is 68.183 °.
The calcium citrate of the preparation of melt-blending process prepared by this example/37 DEG C of polylactic acid bone renovating material constant temperature is impregnated
Biological mineralization experiments are carried out in SBF simulated body fluid, are sampled after 7 days and are observed again by scanning electron microscope.Fig. 3
Calcium citrate/polylactic acid bone renovating material scanning electron of melt-blending process preparation after as impregnating SBF simulated body fluid 7 days
Microscope photograph.
By calcium citrate/polylactic acid bone renovating material of the melt-blending process prepared in this example preparation by being immersed in pH
In=7.4 PBS phosphate buffer solution, to measure calcium citrate/polylactic acid Bone Defect Repari material that in this example prepared by melt-blending process
Expect the degradation situation in phosphate buffer solution.The dry weight for measuring a sample every three days, observes in this example and melts altogether
The degradation situation of calcium citrate/polylactic acid bone renovating material 28d in PBS phosphate buffer solution of mixed method preparation.
Embodiment 2:
Calcium citrate/polylactic acid bone renovating material of the present embodiment melt-blending process preparation is made of polylactic acid and calcium citrate,
By percentage to the quality, the content of calcium citrate is 1%, remaining is polylactic acid；Calcium citrate is four citric acid monohydrate calcium, gathers cream
Acid molecule amount is 200,000.
(1) 9.9 grams of polylactic acid and 0.1 gram of calcium citrate are weighed with electronic balance；
(2) load weighted polylactic acid and calcium citrate are subjected at 180 DEG C melt blending jointly, uniformly divided by stirring to get
Scattered mixture；Mixing speed is 100r/min；
(3) inject the mixture into template, to 5min cooled to room temperature be prepared into melt-blending process preparation calcium citrate/
Polylactic acid bone renovating material.
Calcium citrate/polylactic acid bone renovating material drawing of melt-blending process preparation is measured using omnipotent test machine for mechanism
Stretching intensity is 28.146MPa, elasticity modulus 449.283MPa.
Calcium citrate/polylactic acid bone that the melt-blending process preparation prepared in this example is measured by contact angle measurement is repaired
The water contact angle of multiple material is 74.897 °.
Embodiment 3:
Calcium citrate/polylactic acid bone renovating material of the present embodiment melt-blending process preparation is made of polylactic acid and calcium citrate,
By percentage to the quality, the content of calcium citrate is 10%, remaining is polylactic acid；Calcium citrate is four citric acid monohydrate calcium, gathers cream
Acid molecule amount is 200,000
(1) 9 grams of polylactic acid and 1 gram of calcium citrate are weighed with electronic balance；
(2) load weighted polylactic acid and calcium citrate are subjected to melt blending jointly at 180 DEG C, and divided under agitation
It dissipates and uniformly obtains mixture；Mixing speed is 200r/min；
(3) it injects the mixture into template, obtains calcium citrate/polylactic acid bone of melt-blending process preparation after being cooled to room temperature
Repair materials.
Calcium citrate/polylactic acid the bone for the melt-blending process preparation that this example is prepared is measured using omnipotent test machine for mechanism
The tensile strength of repair materials is 17.625MPa, elasticity modulus 461.386MPa.
Calcium citrate/polylactic acid bone that the melt-blending process preparation prepared in this example is measured by contact angle measurement is repaired
The water contact angle of multiple material is 70.661 °.
Embodiment 4:
Calcium citrate/polylactic acid bone renovating material of the present embodiment melt blending preparation is made of polylactic acid and calcium citrate, with
Mass percent meter, the content of calcium citrate are 30%, remaining is polylactic acid；Calcium citrate is four citric acid monohydrate calcium, polylactic acid
Molecular weight is 200,000
(1) 7 grams of polylactic acid and 3 grams of calcium citrate are weighed with electronic balance；
(2) load weighted polylactic acid and calcium citrate are subjected to melt blending jointly at 180 DEG C, and under agitation
It is uniformly dispersed to obtain mixture；Mixing speed is 300r/min；
(3) it injects the mixture into template, the citric acid of melt-blending process preparation is obtained after 3min cooled to room temperature
Calcium/polylactic acid bone renovating material.
Calcium citrate/polylactic acid the bone for the melt-blending process preparation that this example is prepared is measured using omnipotent test machine for mechanism
The tensile strength of repair materials is 14.176Mpa, elasticity modulus 682.751MPa.
Calcium citrate/polylactic acid bone that the melt-blending process preparation prepared in this example is measured by contact angle measurement is repaired
The water contact angle of multiple material is 57.097 °.Fig. 4 is the calcium citrate/polylactic acid for the melt-blending process preparation that this example is prepared
The contact angle photo of bone renovating material.
Embodiment 5:
Calcium citrate/polylactic acid bone renovating material of the melt-blending process preparation of the present embodiment melt blending preparation by polylactic acid and
Calcium citrate composition, by percentage to the quality, the content of calcium citrate are 20%, remaining is polylactic acid；Calcium citrate is four hydrations
Calcium citrate, polylactic acid molecule amount are 100,000.
(1) 8 grams of polylactic acid and 2 grams of calcium citrate are weighed with electronic balance；
(2) load weighted polylactic acid and calcium citrate are subjected to melt blending jointly at 150 DEG C, and divided under agitation
It dissipates and uniformly obtains mixture；Mixing speed is 200r/min；
(3) inject the mixture into template, obtained after 3min cooled to room temperature melt-blending process preparation calcium citrate/
Polylactic acid bone renovating material.
Calcium citrate/polylactic acid the bone for the melt-blending process preparation that this example is prepared is measured using omnipotent test machine for mechanism
The tensile strength of repair materials is 18.399Mpa, elasticity modulus 661.764MPa.
Calcium citrate/polylactic acid bone that the melt-blending process preparation prepared in this example is measured by contact angle measurement is repaired
The water contact angle of multiple material is 63.555 °.
By calcium citrate/polylactic acid bone renovating material of the melt-blending process prepared in this example preparation by being immersed in pH
In=7.4 PBS phosphate buffer solution, the dry weight of a sample is measured every three days, is observed melt-blending process in this example and is prepared
Calcium citrate/polylactic acid bone renovating material 28d in PBS phosphate buffer solution degradation situation, by 28 days, this example institute
The weightless than reaching 75.82% of composite material is prepared, and the composite material in example 1 is weightless than being only 14.32% by 28 days.
The difference of this example and example 1 is that the polylactic acid molecule amount of example 1 is 200,000, the polylactic acid molecule of this example
Amount is 100,000, and will lead to its degradation speed by the difference that situation of degrading can see polylactic acid molecule amount has notable difference.Cause
Calcium citrate/polylactic acid bone renovating material of this melt-blending process preparation provided by the invention can be by adjusting polylactic acid molecule
The means such as amount improve composite degradation speed, to meet different clinical requirements.
The above description is only an embodiment of the present invention, is not intended to limit the scope of the invention, all to utilize this hair
Equivalent structure or equivalent flow shift made by bright specification and accompanying drawing content is applied directly or indirectly in other relevant skills
Art field, is included within the scope of the present invention.
Claims (9)
1. a kind of calcium citrate/polylactic acid bone renovating material of melt-blending process preparation, it is characterised in that: the material is by melting altogether
Mixed method preparation obtains, is made of, is calculated in mass percent polylactic acid and calcium citrate, and the content of calcium citrate is 1 ~ 30%, remaining
For polylactic acid content.
2. calcium citrate/polylactic acid bone renovating material of melt-blending process preparation according to claim 1, feature exist
In: contained calcium citrate is four water citric acid calcium.
3. calcium citrate/polylactic acid bone renovating material of melt-blending process preparation according to claim 1, feature exist
In: contained polylactic acid molecule amount is 10 ~ 200,000.
4. calcium citrate/polylactic acid bone renovating material of melt-blending process preparation according to claim 1, feature exist
In: its tensile strength is 14 ~ 29Mpa.
5. calcium citrate/polylactic acid bone renovating material of melt-blending process preparation according to claim 1, feature exist
In: its elasticity modulus is 449 ~ 683MPa.
6. calcium citrate/polylactic acid bone renovating material of melt-blending process preparation according to claim 1, feature exist
In: its contact angle is 57 ~ 75 °.
7. calcium citrate/polylactic acid bone renovating material preparation method of melt-blending process preparation according to claim 1,
It is characterized in that: the following steps are included:
(1) polylactic acid and calcium citrate of corresponding proportion are weighed with electronic balance；
(2) load weighted polylactic acid and calcium citrate are subjected to melt blending at 150 ~ 180 DEG C, melt blending includes will be newborn
Acid and the common melt blending of calcium citrate, or polylactic acid is first melt into fluidised form adds calcium citrate and be blended；
(3) by stirring to get finely dispersed mixture；Speed of agitator is 100 ~ 300r/min；
(4) it injects the mixture into mold, cooled to room temperature obtains calcium citrate/polylactic acid of melt-blending process preparation
Bone renovating material.
8. calcium citrate/polylactic acid bone renovating material preparation method of melt-blending process preparation according to claim 1,
Be characterized in that: melt blending includes that polylactic acid is melt into fluidised form again by polylactic acid and the common melt blending of calcium citrate, or first
Calcium citrate is added to be blended.
9. calcium citrate/polylactic acid bone renovating material of the preparation of melt-blending process described according to claim 1 ~ 6, can be applied to
Required bone plate, bone screws, Invasive lumbar fusion device purposes are fixed in orthopaedics.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910530080.4A CN110170074A (en) | 2019-06-19 | 2019-06-19 | A kind of calcium citrate/polylactic acid bone renovating material of melt-blending process preparation and its application |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910530080.4A CN110170074A (en) | 2019-06-19 | 2019-06-19 | A kind of calcium citrate/polylactic acid bone renovating material of melt-blending process preparation and its application |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN110170074A true CN110170074A (en) | 2019-08-27 |
Family
ID=67698634
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910530080.4A Pending CN110170074A (en) | 2019-06-19 | 2019-06-19 | A kind of calcium citrate/polylactic acid bone renovating material of melt-blending process preparation and its application |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN110170074A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110624136A (en) * | 2019-10-08 | 2019-12-31 | 威高集团有限公司 | Degradable medical composite material and preparation method and application thereof |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1872355A (en) * | 2006-06-29 | 2006-12-06 | 武汉理工大学 | Composite material of RGD polypeptide grafted poly (hydroxyacetic acid-L- lysine-L- lactic acid) / beta tricalcium phosphate, and preparation method |
| CN101185772A (en) * | 2007-12-12 | 2008-05-28 | 彭磊 | Human body hard tissue filling renovation material containing calcium citrate |
| CN101628131A (en) * | 2009-08-25 | 2010-01-20 | 华中科技大学 | Method for preparing ultra-thin porous lamination gradient composite support of tissue engineering |
| US20120277882A1 (en) * | 2011-04-29 | 2012-11-01 | Far Eastern New Century Corporation | Implant composite particle, method for making the same, and uses thereof |
| CN107823715A (en) * | 2017-10-20 | 2018-03-23 | 昆明理工大学 | A kind of compound porous bone tissue engineering scaffolds of PCL/HA and preparation method thereof |
-
2019
- 2019-06-19 CN CN201910530080.4A patent/CN110170074A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1872355A (en) * | 2006-06-29 | 2006-12-06 | 武汉理工大学 | Composite material of RGD polypeptide grafted poly (hydroxyacetic acid-L- lysine-L- lactic acid) / beta tricalcium phosphate, and preparation method |
| CN101185772A (en) * | 2007-12-12 | 2008-05-28 | 彭磊 | Human body hard tissue filling renovation material containing calcium citrate |
| CN101628131A (en) * | 2009-08-25 | 2010-01-20 | 华中科技大学 | Method for preparing ultra-thin porous lamination gradient composite support of tissue engineering |
| US20120277882A1 (en) * | 2011-04-29 | 2012-11-01 | Far Eastern New Century Corporation | Implant composite particle, method for making the same, and uses thereof |
| CN107823715A (en) * | 2017-10-20 | 2018-03-23 | 昆明理工大学 | A kind of compound porous bone tissue engineering scaffolds of PCL/HA and preparation method thereof |
Non-Patent Citations (5)
| Title |
|---|
| WEN-JUN YI等: "Poly(l-lactide)/cyclodextrin/citrate networks modified hydroxyapatite and its role as filler in the promotion to the properties of poly(l-lactide) biomaterials", 《POLYMER》 * |
| XIAO Y等: "Porous composite calcium citrate/polylactic acid materials with high mineralization activity and biodegradability for bone repair tissue engineering", 《INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS》 * |
| 刘雨晴: "生物活性柠檬酸钙基复合骨水泥的制备与性能", 《中国优秀硕士学位论文全文数据库医药卫生科技辑》 * |
| 李刚等: "纳米羟基磷灰石 /聚乳酸多孔生物工程材料的制备与性能", 《高分子材料科学与工程》 * |
| 王珊著: "《环境友好型高分子材料的制备与应用》", 31 December 2017, 王珊著 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110624136A (en) * | 2019-10-08 | 2019-12-31 | 威高集团有限公司 | Degradable medical composite material and preparation method and application thereof |
| CN110624136B (en) * | 2019-10-08 | 2021-12-17 | 威高集团有限公司 | Degradable medical composite material and preparation method and application thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Benedini et al. | Antibacterial alginate/nano-hydroxyapatite composites for bone tissue engineering: Assessment of their bioactivity, biocompatibility, and antibacterial activity | |
| Saska et al. | Bacterial cellulose-hydroxyapatite nanocomposites for bone regeneration | |
| Nie et al. | Physicochemical characterization and biocompatibility in vitro of biphasic calcium phosphate/polyvinyl alcohol scaffolds prepared by freeze-drying method for bone tissue engineering applications | |
| Ji Yin et al. | Preparation and characterization of hydroxyapatite/chitosan–gelatin network composite | |
| Danoux et al. | In vitro and in vivo bioactivity assessment of a polylactic acid/hydroxyapatite composite for bone regeneration | |
| Cui et al. | An injectable borate bioactive glass cement for bone repair: preparation, bioactivity and setting mechanism | |
| Chen et al. | Biodegradable composite scaffolds of bioactive glass/chitosan/carboxymethyl cellulose for hemostatic and bone regeneration | |
| Jin et al. | Bio-inspired mineralization of hydroxyapatite in 3D silk fibroin hydrogel for bone tissue engineering | |
| Zhang et al. | Stimulation of cell responses and bone ingrowth into macro-microporous implants of nano-bioglass/polyetheretherketone composite and enhanced antibacterial activity by release of hinokitiol | |
| Zhong et al. | Degradation pattern of porous CaCO3 and hydroxyapatite microspheres in vitro and in vivo for potential application in bone tissue engineering | |
| Andriano et al. | Biocompatibility and mechanical properties of a totally absorbable composite material for orthopaedic fixation devices | |
| Perez et al. | Injectable collagen/α-tricalcium phosphate cement: collagen–mineral phase interactions and cell response | |
| Wang et al. | Self‐setting properties of a β‐dicalcium silicate reinforced calcium phosphate cement | |
| EP2334346A2 (en) | Composite material consisting of a collagen matrix mineralised with silicate and calcium phosphate phases, method for the production and use thereof | |
| Jiang et al. | Preparation and characterization of a novel composite containing carboxymethyl cellulose used for bone repair | |
| Golafshan et al. | Combinatorial fluorapatite-based scaffolds substituted with strontium, magnesium and silicon ions for mending bone defects | |
| Borhan et al. | Evaluation of colloidal silica suspension as efficient additive for improving physicochemical and in vitro biological properties of calcium sulfate-based nanocomposite bone cement | |
| Félix Lanao et al. | Accelerated calcium phosphate cement degradation due to incorporation of glucono-delta-lactone microparticles | |
| Rakmae et al. | Physical properties and cytotoxicity of surface-modified bovine bone-based hydroxyapatite/poly (lactic acid) composites | |
| Qi et al. | Development and characterization of an injectable cement of nano calcium-deficient hydroxyapatite/multi (amino acid) copolymer/calcium sulfate hemihydrate for bone repair | |
| CN102488927B (en) | Bone repairing material and preparation method thereof | |
| CN110170074A (en) | A kind of calcium citrate/polylactic acid bone renovating material of melt-blending process preparation and its application | |
| Wei et al. | Study of polymethylmethacrylate/tricalcium silicate composite cement for orthopedic application | |
| Hamad et al. | Effect of zinc oxide on flexural and physical properties of PMMA composites | |
| Martinez et al. | S ynthesis and characterization of a novel scaffold for bone tissue engineering based on W harton's jelly |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20190827 |
|
| WD01 | Invention patent application deemed withdrawn after publication |