CN110169961A - A kind of athletic rehabilitation compound essential oil - Google Patents

A kind of athletic rehabilitation compound essential oil Download PDF

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CN110169961A
CN110169961A CN201910506759.XA CN201910506759A CN110169961A CN 110169961 A CN110169961 A CN 110169961A CN 201910506759 A CN201910506759 A CN 201910506759A CN 110169961 A CN110169961 A CN 110169961A
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essential oil
athletic rehabilitation
group
compound essential
athletic
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CN110169961B (en
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赵华祥
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Medical Science And Technology (shanghai) Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/01—Hydrocarbons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/01—Hydrocarbons
    • A61K31/015—Hydrocarbons carbocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/075—Ethers or acetals
    • A61K31/085—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon
    • A61K31/09—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon having two or more such linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/222—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having aromatic groups, e.g. dipivefrine, ibopamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
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  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
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  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The present invention relates to a kind of athletic rehabilitation compound essential oils.Athletic rehabilitation compound essential oil of the invention includes following components: limonene, eudesmol, australene, menthol, terpinyl acetate, linalool, menthones, 4- terpineol, sabinene, 3- thujene, nopinene, methyl eugenol, laurene, p-cymene, β-Se Lin alkene, menthyl acetate, neryl acetate, α-curcumene, α-Se Lin alkene, isomenthone, γ-terpinenes, terpinene, carvacrol.Fracture caused by the essential oil can be repaired because of movement is sprained, extravasated blood, arthralgia, lactic acid accumulation, myalgia.

Description

A kind of athletic rehabilitation compound essential oil
Technical field
The present invention relates to a kind of conditioning essential oils, and in particular to a kind of athletic rehabilitation compound essential oil.
Background technique
Health China, is the strategic objective of our countries, and four elements to secure good health are pleasant mood, fortune appropriate Dynamic, sufficient sleep and reasonable diet, injury gained in sports caused by incorrect movement are to cause the extra cost of preventive medicine Increase, including sportsman due to long-term damage do not cure thoroughly and continue movement caused by advance retired phenomenon often produce Raw, the therapeutic modality that modern medicine injures mainstream for caused by injury gained in sports is drug therapy, operation and physical treatment, human body It needs to promote wound healing by the natural mode of some physics, removes blood stasis, mitigate inflammation and pain.And natural essential oil It is used in the first class club of west and has been frequently used, movement bring sludging, lactic acid accumulation can be effectively relieved And improve sports level.The present invention is based on the promoting blood circulation of natural essential oil, stagnation resolvation, analgesic and movement is developed to the elimination mechanism of inflammation Rehabilitation essential oil.
Summary of the invention
It fractures, sprains, extravasated blood, joint caused by technical problem to be solved by the invention is to provide a kind of repair because of movement The athletic rehabilitation compound essential oil of pain.
To solve this technical problem, present invention provide the technical scheme that
A kind of athletic rehabilitation compound essential oil, which is characterized in that including following components:
Limonene
Eudesmol
Australene
Menthol
Terpinyl acetate
Linalool
Menthones
4- terpineol
Sabinene
3- thujene
Nopinene
Methyl eugenol
Laurene
P-cymene
β-Se Lin alkene
Menthyl acetate
Neryl acetate
α-curcumene
α-Se Lin alkene
Isomenthone
γ-terpinenes
Terpinene
Carvacrol.
Further, a kind of athletic rehabilitation compound essential oil, the weight proportion of each component are provided are as follows:
Further, a kind of athletic rehabilitation compound essential oil, the percentage composition of each component are provided are as follows:
Further, a kind of athletic rehabilitation compound essential oil, the percentage composition of each component are provided are as follows:
Limonene (Limonene), can prevent the generation of diabetic osteopathy: limonene treatment can significantly improve skeletonization Collage synthesis, alkaline phosphatase activities, osteocalcin synthesis and the mineralising of cell.Cell before limonene pretreatment of mice osteoblast It is cell death and the apoptosis that MC3T3-E1 cell can prevent methyl-glyoxal (MG) induction, can also reduces the endoplasmic reticulum of MG initiation (ER) stress.In addition, limonene processing can significantly reduce the autophagy activity and Active oxygen release of magnesium induction.
Eudesmol (Eucalyptol), has effects that following: 1. anti-inflammatory, analgesia: mitigating oedema and mechanical nociceptive, drop Low inflammatory cytokine (IL-1, TNF- and IL-6) is horizontal；Anti-inflammatory, analgesia, it may be possible to treat a kind of clinical phase of oral cavity prosopodynia The supplementary means of pass, this may be eudesmol by realizing as a kind of 1 channel antagonist of TRPV；By reducing matrix The NF-B access that matrix metalloproteinases-9 (MMP-9) expression and extracellular signal-regulated kinase rely on plays anti-in Acute lung inflammation Inflammation effect.2. antibacterial: being effective inhibitor of salmonella typhimurium target protein L-ASP, can be used as treatment infection With the secure replacement product of the chemical compound to resisting multidrug-resistant bacteria；As efflux pump inhibitor, restore existing antibiotic (ring Third husky star) to the inhibiting effect of multi-drug resistant bacteria (Acinetobacter bauamnnii and pseudomonas aeruginosa)；It is living that intravaginal can be significantly reduced Bacterium and Candida albicans quantity reduce mouse vagina tissue myeloperoxidase activity, moreover it is possible to inhibit proinflammatory cytokine (IL-1 β, IL-6, TNF-α), the expression of COX-2, iNOS, inhibit the activation of NF- κ B, increase the expression of anti-inflammatory cytokines IL-10, also The expression of proinflammatory cytokine and the activation of NF- κ B in the peritoneal macrophage that lipopolysaccharides can be inhibited to stimulate.
Australene (alpha-Pinene), have anti-inflammatory efficacy: australene (α-pinene) is by inhibiting inhibition of mitogen-activated Protein kinase (MAPKs) and nuclear Factor-Kappa B (NF-k) and have anti-inflammatory effect；Australene is by inhibiting Turnover of Mouse Peritoneal Macrophages MAPK and NF- κ B access and have anti-inflammatory activity, be a kind of potential anti-inflammatory drug for treating various diseases associated with inflammation；Intraperitoneal injection Australene can reduce the ratio of pancreas weight (PW) and weight (BW) and the level of serum amylase and lipase.Australene Treatment also can be reduced tissue damage and the activity of myeloperoxidase of pancreas and lung.In addition, australene pretreatment reduces rain The production of pancreatic neoplasm necrosin (TNF)-α, -1 β and IL-6 of interleukins (IL) during the acute pancreatitis of frog inducing peptide It is raw.In vitro, australene inhibits the in vitro pancreatic acinar cell death of cyanophycin induction and cell factor to generate.These discovery tables Bright australene has anti-inflammatory effect during the acute pancreatitis of tree toad inducing peptide
Menthol (Menthol), has effects that following: 1. ease pain: result of study shows that menthol may be by blocking electricity The pressure gate channel control Na+ and Ca2+ generates Central Analgesic Effect to inflammatory pain.Menthol can effectively reduce chemical stimulation (capsicum Element, methacrylaldehyde, acetic acid), Pain behaviour caused by damaging heat and inflammation (complete Freund's adjuvant).TRPM8 is that peppermint is alcohol-induced Acute and inflammatory pain analgesic main medium.2. neuromuscular is adjusted: being carried out on the skin using 5% peppermint alcogel Stimulation, uses the miniature surface electromyography that musculus vastus lateralis, vastus medialis, rectus femoris are had recorded to electrode.As a result: in adult In the elderly, under menthol stimulation, the root mean square electromyogram of musculus vastus lateralis and vastus medialis is significantly raised, but without aobvious between two groups Write sex differernce.After carrying out menthol stimulation to the elderly, the frequency of average power (MPF) of musculus vastus lateralis is significantly reduced, but at Nian Renzhong menthol, which has no, to be substantially change.Conclusion: neuromuscular adjusting can be observed using peppermint alcogel at low load.This A kind of new region muscle training method can be guided by having found that it is likely that a bit, obtain Quick-type muscle safely for the elderly.
Linalool (Linalool), has effects that following: 1. anti-inflammatory: anti-inflammatory --- improve lung tissue: linalool is in vitro The expression of proinflammatory cytokine and inflammatory cell signal protein is reduced, is had in vivo with the endotoxemia mouse that linalool is treated There are less alveolar leucocyte and cell factor, and improve lung tissue, it is thin to show that linalool potentially contributes to elimination macrophage The reaction of the proinflammatory reaction of born of the same parents, especially induced by endotoxin.The tumour that linalool reduces LPS induction in vitro and in vivo is bad The generation of extremely-α and interleukin-6.In addition, linalool block LPS stimulation 264.7 cell of RAW in I κ B α α albumen, The phosphorylation of p38, c-Jun terminal Kinase and extracellular signal-regulated kinase.In vivo study discovery, linalool alleviate mouse mould Pathologic state colony variation in type.It the result shows that linalool inhibits inflammation in vitro and in vivo, and may be that treatment is scorching The potential treatment candidate of property disease.Linalool is by inhibiting NF- κ B activation to inhibit the lung inflammation of smoke from cigarette induction.It is anti- It is scorching --- Liver protection: linalool inhibits to mitigate inflammatory reaction by the activation of Nrf 2 and NF- κ B, damages to the liver of LPS/GalN induction Wound has protective effect.2. Cardioprotective: linalool can raise VEGF-B mRNA and protein level, promote protein kinase B (Akt) inhibition of activation and glycogen synthase kinase-3 (3 β of GSK), it may be possible to play a kind of supplement of cardioprotection Mechanism.3. local anaesthesia: the internal Psychopharmacology evaluation of linalool shows that the compound Central nervous system has dosage The sedation of dependence, including syngignoscism, anticonvulsant action and cold service.These neurochemistry effects may be with fragrant camphor tree The local anesthetic activities of alcohol are related.Linalool can reduce the release for inducing acetylcholine, and this effect can be attributed to and cynapse Certain interaction of preceding function.In addition, either declining to the channel on voltage or to receptor activation to micro endplate current Inhibiting effect caused by the dynamics subtracted all shows local anaesthesia effect.4. analgesia: linalool is reduced to full Freund's adjuvant (CFA) the mechanical hypersensitivity and vola oedema induced can also be reduced and be induced by Partial sciatic nerve ligation (PSNL) Mechanical hypersensitivity, show that (-)-linalool may be in terms of developing new clinically relevant drug for treating persistent pain With potential meaning.The analgesic activity of (-)-linalool is mainly due to the thorn of cholinergic, opium energy and dopaminergic system Swash, the blocking of local anaesthesia effect and N-methyl-D-aspartate (NMDA) receptor.(-)-linalool Carrageenan, L- paddy Hyperalgia caused by propylhomoserin and prostaglandin E2 has certain inhibiting effect, prompts the compound may be to neuronal sensitization Pain in the process has certain therapeutic effect.(-)-linalool is naturally occurring enantiomer in essential oil.NO generation/release Reduction is at least partly the molecular mechanism of (-)-linalool analgesic activity, it may be possible to pass through cholinergic and glutamatergic system is joined With mechanism.5. antibacterial: linalool has antifungic action, minimal inhibitory concentration 8mm to Candida albicans ATCC 14053.It is sub- The linalool of MIC concentration can also inhibit the formation of the bacterial strain gonoduct and biomembrane.Linalool turns the form of Candida albicans Changing has certain interference effect with biofilm formation.Linalool is a kind of antifungal drug with anti-Trichophyton rubrum potentiality, It is a kind of important Dermatological Agents.
Menthones (Menthone) has refrigerant, analgesic, antipruritic, anti-inflammatory efficacy: menthones is widely used as freshener, delays Solve the counter-stimulus and treatment pruritus of pain.The proinflammatory cytokine, white that menthones can inhibit lipopolysaccharides (LPS) to induce - 1 β of cytokine (IL-1 β) and tumor necrosis factor-alpha (TNF-α) and by LPS and other inflammation agent (including 12-O- 14 Alkane acyl Buddhist wave acetate -13, hydrogen peroxide, okadaic acid and ceramide) induction nuclear factor kappa KB (NF- κ B) activity. It is migrated into nucleus by the NF- κ B of LPS activation in addition, our data are also demonstrated and inhibited by menthones, and I- κ B and β- Transduction repeats to be involved in this inhibition comprising albumen (β-TrCP).
4- terpineol (Terpinen-4-ol) has effects that following: 1. antibacterial: can reduce containing for fungal bacterial strain ergosterol Amount has antifungal activity to dimorphism fungi, Podbielniak pseudomonad and pod membrane nematode.It can be induced by endogenous and extrinsic pathway Human leukemia Molt-4 Apoptosis can inhibit active person monocytic cell and generate pro-inflammatory mediator, anticonvulsion, inhibit oral candidiasis Bacterium inhibits and kills methicillin-resistant staphylococcus aureus and coagulase-negative staphylococci, do not have to human fibroblasts Toxicity, anti-mouse AE17 mesenchymoma and B16 melanoma.2. anti-inflammatory: in the human macrophage that can inhibit lipopolysaccharides (LPS) stimulation The generation of inflammatory mediator, this inhibiting effect are realized by interference NF-kB, p38 or ERK MAPK access.
Sabinene (SABINENE) has effects that following: 1. antibacterial: to staphylococcus aureus, enterococcus faecalis, Escherichia coli It is active with Klebsiella Pneumoniae.Sabinene shows living to the antibacterial for the Gram-positive and gramnegative bacterium tested Property, i.e. staphylococcus aureus, Escherichia coli and its multiple drug resistant bacteria, methicillin-resistant staphylococcus aureus and production is super wide Compose the Escherichia coli of beta-lactamase.2. anti-oxidant, anti-inflammatory: sabinene significantly inhibits NO and generates without influencing cell viability, and shows Very effective NO is shown and removes potentiality, the natural origin that can be used as new antioxidant and anti-inflammatory agent is explored.
Invention also provides above-mentioned athletic rehabilitation compound essential oils to prepare the application in athletic rehabilitation product.
The preparation method of essential oil provided by the invention can buy above-mentioned essential oil from market, and directly mix these essential oils Close uniformly to get.
It further, can also be by method of extraction of essential oil such as steam distillation, supercritical carbon dioxide extractings from virtue Fragrant plant obtains natural essential oil, such as can be respectively from permanent flower, thyme, eucalyptus oil, peppermint, marjoram, olibanum, myrrh, It is extracted in the different plant such as pine tree, lavender, cloves, cortex cinnamomi, corresponding chemical constituent lemon is then obtained by fractionating technology Lemon alkene, eudesmol, australene, menthol, terpinyl acetate, linalool, menthones, 4- terpineol, sabinene, 3- thujene, The ingredients such as nopinene, methyl eugenol, laurene, p-cymene are formed further according to certain proportions.
Essential oil, can be applied directly to painful area by the application method of essential oil provided by the invention, and massage absorbs.
In athletic rehabilitation product, the dosage of above-mentioned athletic rehabilitation compound essential oil is 1ML/ times, 3 times/day.The product Dosage form includes aerosol, spray, fumigating agent, Nasal inhalant.
Beneficial effects of the present invention: essential oil provided by the invention selects the plant extract containing active skull cap components to form, Prescription proportion science, does not add any artificial synthesis group point, and safe without toxic side effect is fractured caused by repairing because of movement, sprains, Extravasated blood, arthralgia, lactic acid accumulation, myalgia.
Detailed description of the invention
Fig. 1 is that the SPME-GC/MS of athletic rehabilitation compound essential oil of the invention analyzes map.
Specific embodiment
Present invention will be further explained below with reference to specific examples.It should be understood that these embodiments are merely to illustrate the present invention Rather than it limits the scope of the invention.In the following examples, the experimental methods for specific conditions are not specified, usually according to conventional strip Part or according to the normal condition proposed by manufacturer.Unless otherwise stated, otherwise all percentage, ratio, ratio or number is pressed Poidometer.
Unless otherwise defined, all professional and scientific terms as used herein and meaning familiar to those skilled in the art Justice is identical.In addition, any method similar to or equal to what is recorded and material can be applied to the method for the present invention.Wen Zhong The preferred implement methods and materials are for illustrative purposes only.
Embodiment 1
The preparation of relieve stagnation sleeping compound essential oil of the invention: the essential oil of selection following weight proportion is mixed with to obtain:
The identification of the athletic rehabilitation compound essential oil of the invention of embodiment 2
By athletic rehabilitation compound essential oil inspection (Shanghai Yu Xiang Biotechnology Co., Ltd) of the invention, inspection number is 190125-1 carries out SPME-GC/MS detection and analysis, as a result as shown in Figure 1.
The trial population of the athletic rehabilitation compound essential oil of the invention of embodiment 3
Test the influence that an athletic rehabilitation compound essential oil Dichlorodiphenyl Acetate of the invention causes mouse capillary permeability
Selection 18-22g male mice in kunming 108, is randomly divided into 9 groups, every group 12.1st group is positive controls, The Indomethacin tablets of 2.5mg/kg dosage are given in group stomach-filling before testing；2nd group is 1 group of blank control, and the group is in test The cotton balls immersed with 1.0g physiological saline is put into mouse cage；3rd group is 2 groups of blank control, and the group is in test to mouse body Upper wiping 1.0g physiological saline；4th group is 1 high dose inhalation group of embodiment, which places to absorb into mouse cage in test has The cotton balls of 2.0g essential oil；5th group is 1 middle dosage inhalation group of embodiment, which places to absorb into mouse cage in test 1.0g The cotton balls of essential oil；6th group is 1 low dosage inhalation group of embodiment, which places to absorb into mouse cage in test 0.5g essential oil Cotton balls；7th group is 1 high dose wiping group of embodiment, and the group is in test to wiping 2.0g essential oil with mouse；8th group is 1 middle dosage wiping group of embodiment, the group is in test to wiping 1.0g essential oil with mouse；9th group is wiped for 1 low dosage of embodiment Group is wiped, the group is in test to wiping 0.5g essential oil with mouse.2nd and 4-6 group change cotton balls 2 times daily.
1h after the last administration, 0.5% Evans blue dye liquid 0.1mL/10g of tail vein injection, while being injected intraperitoneally 0.6% It is put to death after acetum 0.1mL/10g, 20min, with 5mL normal saline flushing abdominal cavity, washing lotion is centrifuged 5min with 1500r/min, It takes supernatant at 590nm, measures absorbance.The results are shown in Table 1.
The athletic rehabilitation compound essential oil Dichlorodiphenyl Acetate of the invention of table 1 causes the influence of mouse capillary permeability
Group Dosage Absorbance
Positive controls 2.5mg/kg 0.586±0.285**
1 group of blank control 0 1.516±0.154
2 groups of blank control 0 1.454±0.268
High dose inhalation group 2.0g 0.762±0.387**
Middle dosage inhalation group 1.0g 1.231±0.296
Low dosage inhalation group 0.5g 1.398±0.421
High dose wiping group 2.0g 0.595±0.166**
Middle dosage wiping group 1.0g 0.968±0.233*
Low dosage wiping group 0.5g 1.106±0.356*
*p<0.05 **p<0.01
Test the influence that two athletic rehabilitation compound essential oil Carrageenans of the invention cause rat paw edema
Wistar rat 108 of 180 ± 10g of weight are selected, are randomly divided into 9 groups, every group 12.1st group is positive right According to group, the Indomethacin tablets of 2.5mg/kg dosage are given in group stomach-filling before testing；2nd group is 1 group of blank control, which is trying The cotton balls immersed with 1.0g physiological saline is put into when testing into mouse cage；3rd group is 2 groups of blank control, and the group is in test Shi Xiang little 1.0g physiological saline is wiped with mouse；4th group is 1 high dose inhalation group of embodiment, which, which places in test into mouse cage, inhales Receive the cotton balls for having 2.0g essential oil；5th group is 1 middle dosage inhalation group of embodiment, which places to absorb into mouse cage in test has The cotton balls of 1.0g essential oil；6th group is 1 low dosage inhalation group of embodiment, which places to absorb into mouse cage in test 0.5g The cotton balls of essential oil；7th group is 1 high dose wiping group of embodiment, and the group is in test to wiping 2.0g essential oil with mouse；8th Group is 1 middle dosage wiping group of embodiment, and the group is in test to wiping 1.0g essential oil with mouse；9th group is 1 low dose of embodiment Wiping group is measured, the group is in test to wiping 0.5g essential oil with mouse.2nd and 4-6 group change cotton balls 2 times daily.Continuous 5 days.
Before last dose, each group rat toes volume is measured, after last dose 30min, the injection of each group right hind foot of rat toe 1% Carrageenan solution 0.1ml measures toes solvent respectively at 1h, 2h and 4h, calculates swelling.Degree of paw swelling=cause is scorching Toes volume before toes volume-cause is scorching afterwards.The results are shown in Table 2.
The athletic rehabilitation compound essential oil of the invention of table 2 causes the influence of rat paw edema to Carrageenan
*p<0.05 **p<0.01
High, medium and low dosage inhalation group is not significantly different compared with blank control group, does not give listing herein.
Test three
The people that test participates in has to pull caused by movement, injures, ankle swelling, cervical spondylosis and psoas muscle caused by long-term sitting posture 65 all ages and classes difference damages such as strain, the crowd of different sexes.The essential oil: being applied to painful area by application method, is applied Smear absorption, usage amount, each 1ml, 3 times a day (1ml/ times, 3 times/day).
Test result: 40 strains pull patient and are averaged convalescence 18 days；20 patient with cervical Spondylopathy are averaged rehabilitation in 10 days；5 Position 15 days pain of arthritic is relieved.
The foregoing is merely presently preferred embodiments of the present invention, the substantial technological context being not intended to limit the invention, Substantial technological content of the invention is broadly defined in the scope of the claims of application, any technology entities that other people complete Or method also or a kind of equivalent change, will be regarded if identical with defined in the scope of the claims of application To be covered by among the scope of the claims.

Claims (8)

1. a kind of athletic rehabilitation compound essential oil, which is characterized in that including following components:
Limonene
Eudesmol
Australene
Menthol
Terpinyl acetate
Linalool
Menthones
4- terpineol
Sabinene
3- thujene
Nopinene
Methyl eugenol
Laurene
P-cymene
β-Se Lin alkene
Menthyl acetate
Neryl acetate
α-curcumene
α-Se Lin alkene
Isomenthone
γ-terpinenes
Terpinene
Carvacrol.
2. a kind of athletic rehabilitation compound essential oil according to claim 1, which is characterized in that the weight proportion of each component are as follows:
3. a kind of athletic rehabilitation compound essential oil according to claim 2, which is characterized in that the percentage composition of each component are as follows:
4. a kind of athletic rehabilitation compound essential oil according to claim 3, which is characterized in that the percentage composition of each component are as follows:
5. athletic rehabilitation compound essential oil described in -4 is preparing the application in athletic rehabilitation product according to claim 1.
6. application according to claim 5, which is characterized in that the described in any item athletic rehabilitation compounds of claim 1-4 Dosage of the essential oil in athletic rehabilitation product is 0.5-2ml.
7. application according to claim 6, which is characterized in that the described in any item athletic rehabilitation compounds of claim 1-4 Dosage of the essential oil in athletic rehabilitation product is 0.5ml.
8. according to the described in any item applications of claim 5-7, which is characterized in that the dosage form of the product includes aerosol, spray Mist agent, fumigating agent, Nasal inhalant.
CN201910506759.XA 2019-06-12 2019-06-12 Exercise rehabilitation compound essential oil Active CN110169961B (en)

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CN115484922A (en) * 2020-05-01 2022-12-16 宝洁公司 Mint flavor composition
CN112755010A (en) * 2021-03-02 2021-05-07 苏州大学 Application of menthone in preparing medicine for treating rheumatoid arthritis
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