CN110151568A - Vitamin microemulsion and preparation method thereof - Google Patents
Vitamin microemulsion and preparation method thereof Download PDFInfo
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- CN110151568A CN110151568A CN201910441614.6A CN201910441614A CN110151568A CN 110151568 A CN110151568 A CN 110151568A CN 201910441614 A CN201910441614 A CN 201910441614A CN 110151568 A CN110151568 A CN 110151568A
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- vitamin
- active constituent
- water
- vitamin microemulsion
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- 239000011782 vitamin Substances 0.000 title claims abstract description 68
- 229930003231 vitamin Natural products 0.000 title claims abstract description 68
- 235000013343 vitamin Nutrition 0.000 title claims abstract description 68
- 229940088594 vitamin Drugs 0.000 title claims abstract description 68
- 150000003722 vitamin derivatives Chemical class 0.000 title claims abstract description 66
- 239000004530 micro-emulsion Substances 0.000 title claims abstract description 56
- 238000002360 preparation method Methods 0.000 title claims abstract description 15
- 238000000593 microemulsion method Methods 0.000 title description 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 62
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 24
- 239000002994 raw material Substances 0.000 claims abstract description 14
- 239000002245 particle Substances 0.000 claims abstract description 12
- 238000003756 stirring Methods 0.000 claims abstract description 4
- 239000000470 constituent Substances 0.000 claims description 29
- BJRNKVDFDLYUGJ-RMPHRYRLSA-N hydroquinone O-beta-D-glucopyranoside Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC=C(O)C=C1 BJRNKVDFDLYUGJ-RMPHRYRLSA-N 0.000 claims description 24
- 230000002087 whitening effect Effects 0.000 claims description 17
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 claims description 16
- 229960005323 phenoxyethanol Drugs 0.000 claims description 16
- 229960000271 arbutin Drugs 0.000 claims description 12
- BJRNKVDFDLYUGJ-UHFFFAOYSA-N p-hydroxyphenyl beta-D-alloside Natural products OC1C(O)C(O)C(CO)OC1OC1=CC=C(O)C=C1 BJRNKVDFDLYUGJ-UHFFFAOYSA-N 0.000 claims description 12
- 208000003351 Melanosis Diseases 0.000 claims description 7
- 239000008389 polyethoxylated castor oil Substances 0.000 claims description 7
- 229920002690 Polyoxyl 40 HydrogenatedCastorOil Polymers 0.000 claims description 6
- 239000000203 mixture Substances 0.000 claims description 4
- 239000006210 lotion Substances 0.000 claims description 3
- 235000013399 edible fruits Nutrition 0.000 claims description 2
- 235000009508 confectionery Nutrition 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 18
- 238000005516 engineering process Methods 0.000 abstract description 7
- 239000004359 castor oil Substances 0.000 abstract description 3
- 235000019438 castor oil Nutrition 0.000 abstract description 3
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 abstract description 3
- 206010040880 Skin irritation Diseases 0.000 abstract description 2
- 238000013329 compounding Methods 0.000 abstract description 2
- 238000004945 emulsification Methods 0.000 abstract description 2
- 230000004927 fusion Effects 0.000 abstract description 2
- 230000035699 permeability Effects 0.000 abstract description 2
- 230000036556 skin irritation Effects 0.000 abstract description 2
- 231100000475 skin irritation Toxicity 0.000 abstract description 2
- 235000011187 glycerol Nutrition 0.000 abstract 2
- 239000004480 active ingredient Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000010419 fine particle Substances 0.000 abstract 1
- 238000005303 weighing Methods 0.000 abstract 1
- 210000003491 skin Anatomy 0.000 description 24
- XUMBMVFBXHLACL-UHFFFAOYSA-N Melanin Chemical compound O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C XUMBMVFBXHLACL-UHFFFAOYSA-N 0.000 description 22
- 241000283973 Oryctolagus cuniculus Species 0.000 description 11
- 238000012360 testing method Methods 0.000 description 10
- 239000000463 material Substances 0.000 description 7
- 230000000638 stimulation Effects 0.000 description 7
- 238000002474 experimental method Methods 0.000 description 6
- 235000004443 Ricinus communis Nutrition 0.000 description 4
- 239000006071 cream Substances 0.000 description 4
- 239000000047 product Substances 0.000 description 4
- 239000008159 sesame oil Substances 0.000 description 4
- 235000011803 sesame oil Nutrition 0.000 description 4
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 description 3
- 230000004888 barrier function Effects 0.000 description 3
- 239000013065 commercial product Substances 0.000 description 3
- 230000007794 irritation Effects 0.000 description 3
- 238000005259 measurement Methods 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 2
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 2
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- 239000011324 bead Substances 0.000 description 2
- 230000001804 emulsifying effect Effects 0.000 description 2
- 239000004519 grease Substances 0.000 description 2
- 210000002752 melanocyte Anatomy 0.000 description 2
- 239000003921 oil Substances 0.000 description 2
- GHOKWGTUZJEAQD-ZETCQYMHSA-N (D)-(+)-Pantothenic acid Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-ZETCQYMHSA-N 0.000 description 1
- 241000208340 Araliaceae Species 0.000 description 1
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 description 1
- 235000003140 Panax quinquefolius Nutrition 0.000 description 1
- 208000012641 Pigmentation disease Diseases 0.000 description 1
- 206010072170 Skin wound Diseases 0.000 description 1
- 102000003425 Tyrosinase Human genes 0.000 description 1
- 108060008724 Tyrosinase Proteins 0.000 description 1
- 229930003268 Vitamin C Natural products 0.000 description 1
- 229930003427 Vitamin E Natural products 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 229960002685 biotin Drugs 0.000 description 1
- 235000020958 biotin Nutrition 0.000 description 1
- 239000011616 biotin Substances 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- FDJOLVPMNUYSCM-WZHZPDAFSA-L cobalt(3+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+3].N#[C-].N([C@@H]([C@]1(C)[N-]\C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C(\C)/C1=N/C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C\C1=N\C([C@H](C1(C)C)CCC(N)=O)=C/1C)[C@@H]2CC(N)=O)=C\1[C@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]1[C@@H](O)[C@@H](N2C3=CC(C)=C(C)C=C3N=C2)O[C@@H]1CO FDJOLVPMNUYSCM-WZHZPDAFSA-L 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000002500 effect on skin Effects 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 1
- 235000008434 ginseng Nutrition 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 238000005286 illumination Methods 0.000 description 1
- 230000008595 infiltration Effects 0.000 description 1
- 238000001764 infiltration Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000003550 marker Substances 0.000 description 1
- 230000008099 melanin synthesis Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 229960003512 nicotinic acid Drugs 0.000 description 1
- 239000011664 nicotinic acid Substances 0.000 description 1
- 235000001968 nicotinic acid Nutrition 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000012466 permeate Substances 0.000 description 1
- 230000019612 pigmentation Effects 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 238000012797 qualification Methods 0.000 description 1
- 230000003595 spectral effect Effects 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 239000011715 vitamin B12 Substances 0.000 description 1
- 239000011708 vitamin B3 Substances 0.000 description 1
- 239000011675 vitamin B5 Substances 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 230000037314 wound repair Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/06—Emulsions
- A61K8/068—Microemulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/602—Glycosides, e.g. rutin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
- A61K8/675—Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/676—Ascorbic acid, i.e. vitamin C
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
- A61K2800/782—Enzyme inhibitors; Enzyme antagonists
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Dermatology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Emergency Medicine (AREA)
- Dispersion Chemistry (AREA)
- Cosmetics (AREA)
Abstract
The invention relates to the field of skin care products, in particular to a vitamin microemulsion and a preparation method thereof, the vitamin microemulsion is prepared by compounding basic components and active components, wherein the basic components comprise glycerin, PEG-40 hydrogenated castor oil and water, and the active components comprise VB12、VC、VE、VB3And VB5. The preparation method of the vitamin microemulsion comprises the following steps: a. weighing the required raw materials in parts by weight; b. mixing the above raw materials, stirring rapidly to make each active ingredient dispersed and wrapped in fine particles to form vitamin microemulsion with particle diameter of 100A-2000A. The micro-emulsification technology is adopted to compound a plurality of vitamins with the glycerol, the PEG-40 hydrogenated castor oil and the water, the safety is high, the problem of skin irritation caused by a single vitamin is solved by the fusion effect of the plurality of vitamins, the permeability of the vitamin is improved, and the utilization rate is higher.
Description
Technical field
The present invention relates to skin care fields, specifically vitamin microemulsion and preparation method thereof.
Background technique
Vitamin is one of big nutrient of human body six, and different vitamin plays the role of different, is generated in skin care item
Different skin effects are encountered light, oxygen, heat etc. and are more easily damaged due to the unstability of vitamin, if protected without certain technology
Barrier, it is even higher that activity can lose 50%.
In existing skin care item preparation, common emulsifying technology is mostly used greatly, Material diameter made from common emulsifying technology is big,
The effective component largely separated can be remained in skin surface by the active force generated when smearing, can not be completely absorbed, by
In the unstability of vitamin, so that application of the vitamin in skin care item is few or undesirable with rear effect.Therefore, such as
The characteristic of vitamin is played reservation by what to the greatest extent, few to solve application of the prior art vitamin in skin care item,
It or with the undesirable problem of rear effect is the direction to be studied of the invention.
Summary of the invention
In view of this, the present invention provides vitamin microemulsion and preparation method thereof, a variety of dimensions are given birth to using micro-emulsion technology
Element is compounded with glycerol, Cremophor RH40 and water, highly-safe, and multivitamin fusion solves single dimension
Raw element improves the permeability of vitamin to the irritation problem of skin.
To achieve the goals above, the invention adopts the following technical scheme:
Vitamin microemulsion is compounded by basis and active constituent, wherein basis includes glycerol, PEG-40
Rilanit special and water；Active constituent includes VB12、VC、VE、VB3And VB5。
Preferably, vitamin microemulsion, by weight, basis specifically include: 12-15 parts of glycerol, PEG-40 hydrogen
Castor oil 4-5.5 parts of change, 70-75 parts of water and 0.3-0.7 parts of Phenoxyethanol；Active constituent specifically includes: VB121-3 parts, VC5-
6.5 parts, VE2-4 parts, VB30.5-1.5 parts and VB50.5-1.5 parts.
Preferably, in said vitamin microemulsion, active constituent further includes having VF and/or VH.
Preferably, vitamin microemulsion, by weight, basis specifically include: 14 parts of glycerol, PEG-40 hydrogenate castor
5 parts of sesame oil, 72 parts of water and 0.5 part of Phenoxyethanol；Active constituent specifically includes: VB121.5 parts, VC6 parts, VE3 parts, VB31 part,
VB51 part and VF3 parts.
Preferably, vitamin microemulsion, by weight, basis specifically include: 14 parts of glycerol, PEG-40 hydrogenate castor
5 parts of sesame oil, 72 parts of water and 0.5 part of Phenoxyethanol；Active constituent specifically includes: VB121.5 parts, VC6 parts, VE3 parts, VB31 part,
VB51 part and VH3 parts.
Preferably, in said vitamin microemulsion, active constituent further includes having D Arbutin.
Preferably, vitamin microemulsion, by weight, basis specifically include: 14 parts of glycerol, PEG-40 hydrogenate castor
5 parts of sesame oil, 72 parts of water and 0.5 part of Phenoxyethanol；Active constituent specifically includes: VB121.5 parts, VC6 parts, VE3 parts, VB31 part,
VB51 part and 2-5 parts of D Arbutin.
Preferably, vitamin microemulsion, by weight, basis specifically include: 14 parts of glycerol, PEG-40 hydrogenate castor
5 parts of sesame oil, 72 parts of water and 0.5 part of Phenoxyethanol；Active constituent specifically includes: VB121.5 parts, VC6 parts, VE3 parts, VB31 part,
VB51 part and 3 parts of D Arbutin.
Preferably, above-mentioned manufactured vitamin microemulsion is added in any water phase and is applied to whitening and/or nti-freckle
In class skin care item.
The preparation method of vitamin microemulsion comprising:
A, required raw material is weighed by weight；
B, will above-mentioned each raw material mix after quickly stir, make each active constituent dispersed encapsulated into tiny particle, form it into
Vitamin microemulsion of the particle diameter between 100A-2000A.
Preferably, in stepb, the speed of agitator is 500-2000r/min, mixing time 10-60min, the ginseng
Number can be such that activating agent glycerol, PEG4- rilanit special and active constituent quickly rotates, and it is thin that active constituent is easily dispersed into extremely children
Particle formed microemulsion, the microemulsion in water solubility, extremely soluble in water phase product, stability is good, bioavilability
It is high.
Wherein, Phenoxyethanol is used as preservative.
Compared with prior art, it the principle of the present invention and has the beneficial effect that:
1, multivitamin is compounded with glycerol, Cremophor RH40 and water, it is highly-safe, and multivitamin merges
Effect solves the problems, such as single vitamin to the irritation of skin；
2, using micro-emulsion technology, even if Material is made to occur water-oil separating under smear effect power, the grease of Material mutually can be spontaneous
Property again emulsification so that Material is returned to equilibrium state, tiny micro emulsion bead carries effective active composition in the state of the equilibrium can be with
Infiltration rapidly, human skin absorb more preferably, which can make vitamin play main functional component, and availability is high；
3, by compounding D Arbutin, on the one hand for adjusting the generation of melanin, overcome pigmentation, desalinate skin black spots
Point, has a rapid and lasting skin whitening effects, another aspect D Arbutin to the inhibiting effect effect of tyrosinase more
It is good, while adjusting melanin production, the oxidation of each active constituent (i.e. vitamin) can be inhibited, auxiliary improves vitamin
Availability.
Specific embodiment
The technical solution in the present invention is clearly and completely described below in conjunction with embodiment, it is clear that described
Embodiment is only a part of the embodiment of the present invention, instead of all the embodiments.Based on the embodiments of the present invention, this field
Those of ordinary skill's all other embodiment obtained without creative efforts, belongs to protection of the present invention
Range.
Embodiment 1
Vitamin microemulsion, by weight, basis specifically include: 13 parts of glycerol, 4.5 parts of Cremophor RH40,
72 parts and 0.5 part of Phenoxyethanol of water, active constituent specifically includes: VB121.5 parts, VC6 parts, VE3 parts, VB31 part, VB51 part.
In embodiment 1, the preparation method of vitamin microemulsion, comprising:
A, weigh 13 parts of glycerol, 4.5 parts of Cremophor RH40,72 parts of water and 0.5 part of Phenoxyethanol make basis, weigh
VB121.5 parts, VC6 parts, VE3 parts, VB31 part, VB51 part is made active constituent；
B, 35min is stirred with the frequency of 1000r/min after mixing above-mentioned raw materials, makes VB12、VC、VE、VB3、VB5It is each activity at
Point dispersed encapsulated forms it into vitamin microemulsion of the particle diameter between 100A-1000A into tiny particle.
Embodiment 2
Vitamin microemulsion, by weight, basis specifically include: 13 parts of glycerol, 4.5 parts of Cremophor RH40,
72 parts and 0.5 part of Phenoxyethanol of water, active constituent specifically includes: VB121.5 parts, VC6 parts, VE3 parts, VB31 part, VB51 part, VF3
Part.
In embodiment 2, the preparation method of vitamin microemulsion, comprising:
A, weigh 13 parts of glycerol, 4.5 parts of Cremophor RH40,72 parts of water and 0.5 part of Phenoxyethanol make basis, weigh
VB121.5 parts, VC6 parts, VE3 parts, VB31 part, VB51 part, VF3 parts is made active constituent；
B, 23min is stirred with the frequency of 1500r/min after mixing above-mentioned raw materials, makes VB12、VC、VE、VB3、VB5With each work of VF
Property ingredient dispersed encapsulated forms it into vitamin microemulsion of the particle diameter between 100A-800A into tiny particle.
Embodiment 3
In embodiment 3, part same as Example 2 is repeated no more, unlike:
VF3 part in embodiment is replaced with VH3 parts by inventor, accordingly replaces with VH3 parts for VF3 parts in preparation method, other
Vitamin microemulsion is made in each parameter constant.
Embodiment 4
Vitamin microemulsion, by weight, basis specifically include: 13 parts of glycerol, 4.5 parts of Cremophor RH40,
72 parts and 0.5 part of Phenoxyethanol of water, active constituent specifically includes: VB121.5 parts, VC6 parts, VE3 parts, VB31 part, VB51 part, D bear
4 parts of fruit element.
In embodiment 4, the preparation method of vitamin microemulsion, comprising:
A, weigh 13 parts of glycerol, 4.5 parts of Cremophor RH40,72 parts of water and 0.5 part of Phenoxyethanol make basis, weigh
VB121.5 parts, VC6 parts, VE3 parts, VB31 part, VB51 part, 4 parts of D Arbutin is made active constituent；
B, 35min is stirred with the frequency of 1800r/min after mixing above-mentioned raw materials, makes VB12、VC、VE、VB3、VB5With D Arbutin
Each active constituent dispersed encapsulated forms it into vitamin micro emulsion of the particle diameter between 100A-1000A into tiny particle
Liquid.
Embodiment 5
In embodiment 5, part same as Example 4 is repeated no more, unlike:
4 parts of D Arbutin in embodiment 4 are replaced with 3 parts of D Arbutin by inventor, accordingly by 4 parts of D Arbutin in preparation method
3 parts of D Arbutin are replaced with, vitamin microemulsion is made in remaining parameter constant.
Multiple skin irritation test
The weight of skin zero damage is chosen as 2-2.5kg experimental rabbit several are randomly divided into five groups, every group at least four, test
Preceding to shave off experimental rabbit back hair, unhairing range is the small cube of 3cm, and vitamin microemulsion made from embodiment 1-5 is made
It is added separately to be prepared into five groups of whitening and spot eliminating creams in other identical raw materials for raw material, above-mentioned five groups of whitening and spot eliminating creams is uniform
It is applied to the unhairing position of above-mentioned experimental rabbit, once a day, is every time cleaned spreader portion after 8 hours, it is continuous to smear one week, respectively
Dermoreaction is observed under full spectrum light after one day, three days, seven days, and presses " cosmetics health specification " skin wound repair
Standards of grading (referring to table 1) record experimental data, and experimental data is referring to table 2.
Table 1
Table 2
In table 2,1ax, 2ax, 3ax, 4ax represent point of the score value of first experimental rabbit in the embodiment, second experimental rabbit
Value, the score value of third experimental rabbit, the 4th experimental rabbit score value, wherein x is the specific stimulation score value of experimental rabbit, and x is in 0-8
Between, the calculation formula of stimulation degree y is, total score/(experimental rabbit quantity × 7) in Y=every experimental rabbit 7 days.
When stimulation degree y is lower than 0.5, it is nonirritant, is subexcite when stimulation degree y is greater than 0.5 less than 2.0, when
Stimulation degree y is medium irritation when being greater than 2.0 less than 6.0, is strong and stimulating when stimulation degree y is greater than 6.0.
From the data in table 2, it can be seen that vitamin microemulsion made from above-described embodiment 1-5 is stingless to the stimulation degree of experimental rabbit
Swash property, qualification rate 100%.
Specific effect experiment
The age is selected to be in obscure unglazed and having color spot volunteer 10 of face between 25-30 years old, men and women is unlimited, selects at random
5 volunteers use respectively vitamin microemulsion made from 1-5 of the embodiment of the present invention as raw material be added separately to it is identical its
He is prepared into five groups of whitening and spot eliminating creams in raw material, application method is to take whitening and spot eliminating cream to be uniformly applied to face after daily face cleaning,
By residue 5 volunteers use respectively stochastic buying in the market five kinds of different brands freckle removing and whitening product as a comparison case,
Application method counts effect simultaneously after continuous use three months, three months daily morning and evening twice according to the normal usage of commercial product
It takes pictures comparison, experiment effect is as shown in table 3.
Table 3
Experiment effect evaluation criterion in table 3 are as follows:
When color spot area decreases below 10% or less, freckle effect is denoted as generally；
When color spot area, which is reduced, is higher than 10% lower than 30%, freckle effect is denoted as well；
When color spot area, which is reduced, is in 30% or more, freckle effect note has outstanding；
With the skin-color number of volunteer before and after skin colorimetric card comparative test, skin-color rank is higher, represents tester's skin
It is whiter.
When skin-color rank promotes 2 grades or less, whitening effect is denoted as generally；
When skin-color rank promotes 2 grades or more 4 grades or less, whitening effect is denoted as well；
When skin-color rank promotes 4 grades or more, whitening effect is denoted as outstanding.
By 3 experimental data of table it is found that dispelling in participating in 5 embodiments using vitamin microemulsion produced by the present invention
Spot excellent has 4, whitening effect it is outstanding have 4, in participating in 5 embodiments using commercial like product, dispel
Spot excellent has 1, whitening effect it is outstanding have 1, Comprehensive Correlation, vitamin microemulsion effect produced by the present invention is bright
It is aobvious to be better than commercial product.
Melanin removes test experiments
It selects the age to be in volunteer 5 between 35-45 years old, uses melanocyte detector test volunteer before experiment respectively
The melanin quantity (before being denoted as L) in left arm top somewhere and the melanin quantity (before being denoted as R) in right arm top somewhere, and in this position
Tagging, when experiment, are covered the position with barrier paper, and hollow out has the square of 3cm on barrier paper, and square center is in marker bit
It sets, it is micro- added with vitamin made from 1-5 of the embodiment of the present invention in right amount that smearing (is exposed at skin) at volunteer's left arm square
The whitening spot-removing class skin care item of lotion, then (expose at skin) at volunteer's right arm square and smear appropriate commercially available like products
Freckle removing and whitening lotion cleans test portion before smearing every time once a day, after continuous three months after record test on volunteer's left arm
Melanin quantity (after being denoted as R) that volunteer's right arm top should go out after melanin quantity (after being denoted as L) and test of the portion at this, and
Melanin removal rate is calculated, test data is as shown in table 4.
It should be noted that above melanocyte detector is the principle (RGB) based on spectral absorption, pass through measurement
The illumination of specific wavelength on human skin after volume reflection be to determine the content of melanin in skin, the measurement range of instrument
0~999, measurement numerical value is higher, illustrates that the content of melanin in skin is higher.
Table 4
From the data in table 4, it can be seen that being given birth in 5 volunteers for participating in test using added with dimension made from 1-5 of the embodiment of the present invention
The whitening spot-removing class skin care item of plain microemulsion, melanin removal rate have 3 30% or more, remaining 2 20% or more, and
Identical volunteer 30% or more is being 0 using melanin removal rate behind commercial product, have 2 20% or more, this be because
To be added with vitamin microemulsion produced by the present invention in embodiment 1-5, the vitamin microemulsion in the present invention uses microemulsified
Technology, even if Material is made to occur water-oil separating under smear effect power, the grease of Material mutually can be emulsified spontaneously again makes Material
Equilibrium state is returned to, tiny micro emulsion bead carries effective active composition in the state of the equilibrium to permeate rapidly, human body skin
Skin absorbs more preferably, which can make vitamin play main functional component, and availability is high, thus can prove by dispelling in whitening
Vitamin microemulsion resultant effect produced by the present invention is added in spot class skin care item more preferably.
In addition, in present specification, VB12For vitamin B12, VC is vitamin C, and VE is vitamin E, VB3For nicotinic acid
(also known as vitamin B3), VB5For vitamin B5, VF be vitaminF, VH is biotin.
Finally, it should be noted that present invention disclosed above preferred embodiment is only intended to help to illustrate the present invention.It is excellent
The details that embodiment is all there is no detailed descriptionthe is selected, is not limited the invention to the specific embodiments described.Obviously, root
According to the content of this specification, can make many modifications and variations.These embodiments are chosen and specifically described to this specification, be in order to
The principle of the present invention and practical application are preferably explained, so that skilled artisan be enable to better understand and utilize
The present invention.The invention is limited only by the claims and the full scope thereof and equivalents thereof.
Claims (10)
1. vitamin microemulsion is compounded by basis and active constituent, it is characterised in that: basis includes sweet
Oil, Cremophor RH40 and water；Active constituent includes VB12、VC、VE、VB3And VB5。
2. vitamin microemulsion according to claim 1, it is characterised in that: by weight, basis specifically includes:
12-15 parts of glycerol, 4-5.5 parts of Cremophor RH40,70-75 parts of water and 0.3-0.7 parts of Phenoxyethanol；Active constituent is specific
It include: VB121-3 parts, VC5-6.5 parts, VE2-4 parts, VB30.5-1.5 parts and VB50.5-1.5 parts.
3. vitamin microemulsion according to claim 2, it is characterised in that: active constituent further includes having VF and/or VH.
4. vitamin microemulsion according to claim 3, it is characterised in that: by weight, basis specifically includes:
14 parts of glycerol, 5 parts of Cremophor RH40,72 parts of water and 0.5 part of Phenoxyethanol；Active constituent specifically includes: VB121.5 parts,
VC6 parts, VE3 parts, VB31 part, VB51 part and VF3 parts.
5. vitamin microemulsion according to claim 3, it is characterised in that: by weight, basis specifically includes:
14 parts of glycerol, 5 parts of Cremophor RH40,72 parts of water and 0.5 part of Phenoxyethanol；Active constituent specifically includes: VB121.5 parts,
VC6 parts, VE3 parts, VB31 part, VB51 part and VH3 parts.
6. vitamin microemulsion according to claim 1-5, it is characterised in that: active constituent further includes having D bear
Fruit element.
7. vitamin microemulsion according to claim 6, it is characterised in that: by weight, basis specifically includes:
14 parts of glycerol, 5 parts of Cremophor RH40,72 parts of water and 0.5 part of Phenoxyethanol, active constituent specifically includes: VB121.5 parts,
VC6 parts, VE3 parts, VB31 part, VB51 part and 3 parts of D Arbutin.
8. the preparation method of -7 any vitamin microemulsions according to claim 1, it is characterised in that: it includes following step
Suddenly,
A, required raw material is weighed by weight；
B, will above-mentioned each raw material mix after quickly stir, make each active constituent dispersed encapsulated into tiny particle, form it into
Vitamin microemulsion of the particle diameter between 100A-2000A.
9. the preparation method of vitamin microemulsion according to claim 8, it is characterised in that: in stepb, the stirring
Revolving speed is 500-2000r/mim, mixing time 10-60min.
10. the application of vitamin microemulsion according to claim 1-7, it is characterised in that: the vitamin is micro-
Lotion is added in whitening and/or nti-freckle class skin care item as a kind of raw material.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910441614.6A CN110151568A (en) | 2019-05-24 | 2019-05-24 | Vitamin microemulsion and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910441614.6A CN110151568A (en) | 2019-05-24 | 2019-05-24 | Vitamin microemulsion and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN110151568A true CN110151568A (en) | 2019-08-23 |
Family
ID=67632862
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910441614.6A Withdrawn CN110151568A (en) | 2019-05-24 | 2019-05-24 | Vitamin microemulsion and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN110151568A (en) |
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2019
- 2019-05-24 CN CN201910441614.6A patent/CN110151568A/en not_active Withdrawn
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Application publication date: 20190823 |