CN110151362A - A kind of Segmental Bone Defect prosthetic device of 3D printing and preparation method thereof - Google Patents
A kind of Segmental Bone Defect prosthetic device of 3D printing and preparation method thereof Download PDFInfo
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- CN110151362A CN110151362A CN201910189718.2A CN201910189718A CN110151362A CN 110151362 A CN110151362 A CN 110151362A CN 201910189718 A CN201910189718 A CN 201910189718A CN 110151362 A CN110151362 A CN 110151362A
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- bone defect
- prosthetic device
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- segmental bone
- body supporting
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/28—Bones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
- A61L27/443—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with carbon fillers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
- A61L27/446—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with other specific inorganic fillers other than those covered by A61L27/443 or A61L27/46
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
- A61L27/46—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with phosphorus-containing inorganic fillers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/56—Porous materials, e.g. foams or sponges
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/58—Materials at least partially resorbable by the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/28—Bones
- A61F2002/2835—Bone graft implants for filling a bony defect or an endoprosthesis cavity, e.g. by synthetic material or biological material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30003—Material related properties of the prosthesis or of a coating on the prosthesis
- A61F2002/3006—Properties of materials and coating materials
- A61F2002/30062—(bio)absorbable, biodegradable, bioerodable, (bio)resorbable, resorptive
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30316—The prosthesis having different structural features at different locations within the same prosthesis; Connections between prosthetic parts; Special structural features of bone or joint prostheses not otherwise provided for
- A61F2002/30329—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
- A61F2002/30476—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements locked by an additional locking mechanism
- A61F2002/30507—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements locked by an additional locking mechanism using a threaded locking member, e.g. a locking screw or a set screw
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/3094—Designing or manufacturing processes
- A61F2/30942—Designing or manufacturing processes for designing or making customized prostheses, e.g. using templates, CT or NMR scans, finite-element analysis or CAD-CAM techniques
- A61F2002/30948—Designing or manufacturing processes for designing or making customized prostheses, e.g. using templates, CT or NMR scans, finite-element analysis or CAD-CAM techniques using computerized tomography, i.e. CT scans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/3094—Designing or manufacturing processes
- A61F2002/30985—Designing or manufacturing processes using three dimensional printing [3DP]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
Abstract
The present invention provides a kind of Segmental Bone Defect prosthetic device and preparation method thereof of 3D printing, the Segmental Bone Defect prosthetic device includes that Segmental Bone Defect repairs ontology, repairs body supporting piece and fixed plate, the Segmental Bone Defect is repaired ontology and is set in the reparation body supporting piece, the reparation body supporting piece is set in the fixed plate, several screw holes are additionally provided in the fixed plate, the Segmental Bone Defect repairs ontology and the global shape for repairing body supporting piece is the shape of defect bone tissue.It is the shape of defect bone tissue that Segmental Bone Defect, which repairs ontology and repairs the global shape of body supporting piece, in Segmental Bone Defect prosthetic device of the present invention, meet personalized medicine demand, pass through preset fixed plate and screw hole, ontology is repaired for Segmental Bone Defect, and incipient stability is provided, and the accuracy rate of screw placement is improved, reduce fluoroscopy during operation number.
Description
Technical field
The invention belongs to Bone Defect Repari technical fields, a kind of Segmental Bone Defect prosthetic device more particularly to 3D printing and
Preparation method.
Background technique
The large segmental bone defect as caused by wound, infection, tumour etc. often results in operating time extension, complication height,
The risks such as amputation rate height are one stubborn problems of current clinical position.Currently, " the gold mark that clinical treatment bone defect is repaired
It is quasi- " it is autologous bone transplanting, however, there is also donor site infection, pain, quantity to have in addition to operating time extends, other than second operation
The problems such as limit, is unfavorable for the reparation of large segmental bone defect.Currently, the bone renovating material for being widely studied and using is mainly metal material
Material, ceramic material and high molecular material.Metal material mechanics excellent performance, but metal material elasticity modulus is high, after implantation being caused
Gravitation blocks, and causes bone resorption.In addition, metal material have metal artifacts, interference images inspection result, be unfavorable for it is postoperative with
It visits.Common ceramic material and high molecular material in existing clinic, bioactivity is high, is conducive to cell and grows and adhere to, bone is promoted to lack
Damage area to repair, but poor mechanical property, can not load-bearing or only partial weight-bearing, be unfavorable for repairing large segmental bone defect.
Summary of the invention
In view of the foregoing deficiencies of prior art, the purpose of the present invention is to provide a kind of Segmental Bones of 3D printing to lack
Damage prosthetic device and preparation method thereof, the prosthetic device include Segmental Bone Defect repair ontology, repair body supporting piece and
Fixed plate, the Segmental Bone Defect are repaired ontology and are set in the reparation body supporting piece, and the reparation body supporting piece is set
In in the fixed plate, being additionally provided with several screw holes in the fixed plate, the Segmental Bone Defect repairs ontology and described
The global shape for repairing body supporting piece is the shape of defect bone tissue.Segmental in Segmental Bone Defect prosthetic device of the present invention
Bone defect healing ontology and the global shape for repairing body supporting piece are the shape of defect bone tissue, and meeting personalized medicine needs
It asks, by preset fixed plate and screw hole, repairs ontology for Segmental Bone Defect and incipient stability is provided, and improve screw
The accuracy rate of implantation reduces fluoroscopy during operation number.
In order to achieve the above objects and other related objects, first aspect present invention provides a kind of Segmental Bone Defect reparation dress
It sets, including Segmental Bone Defect repairs ontology, repairs body supporting piece and fixed plate, the Segmental Bone Defect is repaired ontology and set
In in the reparation body supporting piece, the reparation body supporting piece is set in the fixed plate, is additionally provided in the fixed plate
Several screw holes, it is defective bone group that the Segmental Bone Defect, which repairs ontology and the global shape for repairing body supporting piece,
The shape knitted.
Preferably, further include in following technical characteristic at least one of:
1) the reparation body supporting piece and the fixed plate include following raw material and mass percent:
60~100wt% of polyether-ether-ketone, 0~40wt% of hydroxyapatite；Alternatively,
70~100wt% of polyether-ether-ketone, 0~30wt% of carbon fiber；
2) it includes following raw material and mass percent that the Segmental Bone Defect, which repairs ontology:
50~100wt% of biodegradable polymer；
0~50wt% of bioactive metal, such as 0~10wt% or 10~50wt%.
It is highly preferred that feature 2) in, the biodegradable polymer is selected from PCL, at least one of PLA and PLGA,
The bioactive metal is selected from least one of Mg, Cu, Fe, Zn and Sr.
Preferably, further include in following technical characteristic at least one of:
1) the reparation body supporting piece wraps up the Segmental Bone Defect and repairs ontology, repairs in the Segmental Bone Defect
The position that duplicate body is contacted with sclerotin is equipped with the first Bone Ingrowth open ports and the second Bone Ingrowth open ports；
2) fixed plate is successively arranged the first plate segment, the second plate segment and third plate segment, the reparation
Body supporting piece is set in second plate segment, several described screw holes are set to first plate segment and described the
In three plate segments.
It is highly preferred that feature 2) in, at least provided with two screw holes in the fixed plate, one of screw hole is set to institute
It states in the first plate segment, another screw hole is set in the third plate segment.
Preferably, the reparation body supporting piece and the fixed plate are integral.
Preferably, above-mentioned bone defect healing ontology includes several shelf layers, and the shelf layer includes several parallel brackets
Fin, the bracket fin of different layers intersects in adjacent layer, passes through several shelf layers and bracket fin constitutes micropore.
It is highly preferred that further including at least one in following technical characteristic:
1) the bracket fin parallel arrangement in two layers of shelf layer of every phase alternating floor shelf layer；
2) angle [alpha] that the bracket fin of different layers intersects in adjacent layer is 30~90 °；
3) aperture of micropore is 100 μm~1000 μm；Even more preferably, the aperture of micropore is 300 μm~900 μm；
4) porosity of bone defect healing ontology is 40%~90%；Even more preferably, bone defect healing ontology
Porosity is 60%~80%.
Second aspect of the present invention provides the preparation method of above-mentioned Segmental Bone Defect prosthetic device, includes the following steps:
1) bone defect area form is obtained by CT scan；
2) prosthetic device modeling is to obtain prosthetic device model, the bone defect that the prosthetic device model is obtained with step 1)
Area's form is outer profile；
3) 3D printing is carried out according to prosthetic device model.
Preferably, 2 spray heads are used when 3D printing, a spray head is used for the reparation body supporting piece and the fixation
Plate, another spray head repair ontology for printing the Segmental Bone Defect.
As described above, the present invention one of at least has the advantages that:
1) Segmental Bone Defect repairs ontology and repairs body supporting piece in Segmental Bone Defect prosthetic device of the present invention
Global shape is the shape of defect bone tissue, meets personalized medicine demand；
2) it includes several shelf layers that Segmental Bone Defect described in Segmental Bone Defect prosthetic device of the present invention, which repairs ontology,
The shelf layer includes several parallel bracket fins, and the bracket fin of different layers intersects in adjacent layer, passes through several shelf layers
Micropore is constituted with bracket fin, there is the micropore conducive to Bone Ingrowth, it is preferable that the releasable bioactivity gold for promoting Bone Defect Repari
Belong to, improves the Segmental Bone Defect and repair ontology osseointegration character；
3) Segmental Bone Defect prosthetic device of the present invention is lacked by preset fixed plate and screw hole for Segmental Bone
Damage repairs ontology and provides incipient stability, and improves the accuracy rate of screw placement, reduces fluoroscopy during operation number；
4) the reparation body supporting piece and the fixed plate are integral, and are reduced the use of other internal fixation steel plates, are subtracted
Few second operation takes out.
Detailed description of the invention
Fig. 1 is the perspective view of Segmental Bone Defect prosthetic device of the invention.
Fig. 2 is the inside perspective diagram of Segmental Bone Defect prosthetic device of the invention.
Fig. 3 is perspective diagram inside Segmental Bone Defect prosthetic device use state of the invention.
Appended drawing reference:
1 Segmental Bone Defect repairs ontology
11 shelf layers
111 bracket fins
2 repair body supporting piece
21 first Bone Ingrowth open ports
22 second Bone Ingrowth open ports
3 fixed plates
31 screw holes
32 first plate segments
33 second plate segments
34 third plate segments
4 screws
5 patient's sclerotin
Specific embodiment
Embodiments of the present invention are illustrated by particular specific embodiment below, those skilled in the art can be by this explanation
Content disclosed by book is understood other advantages and efficacy of the present invention easily.
It please refers to Fig.1 to Fig.3.It should be clear that this specification structure depicted in this specification institute accompanying drawings, ratio, size etc., only to
Cooperate the revealed content of specification, so that those skilled in the art understands and reads, being not intended to limit the invention can be real
The qualifications applied, therefore do not have technical essential meaning, the tune of the modification of any structure, the change of proportionate relationship or size
It is whole, in the case where not influencing the effect of present invention can be generated and the purpose that can reach, it should all still fall in disclosed skill
Art content obtains in the range of capable of covering.Meanwhile in this specification it is cited as "upper", "lower", "left", "right", " centre " and
The term of " one " etc. is merely convenient to being illustrated for narration, rather than to limit the scope of the invention, relativeness
It is altered or modified, under the content of no substantial changes in technology, when being also considered as the enforceable scope of the present invention.
As depicted in figs. 1 and 2, a kind of Segmental Bone Defect prosthetic device, including Segmental Bone Defect are repaired ontology 1, are repaired
Multiple body supporting piece 2 and fixed plate 3, the Segmental Bone Defect are repaired ontology 1 and are set in the reparation body supporting piece 2, institute
It states and repairs body supporting piece 2 in the fixed plate 3, several screw holes 31, the segment are additionally provided in the fixed plate 3
Property bone defect healing ontology 1 and the global shape for repairing body supporting piece 2 be defect bone tissue shape.
Segmental Bone Defect repairs ontology and repairs the whole of body supporting piece in Segmental Bone Defect prosthetic device of the present invention
Shape is the shape of defect bone tissue, meets personalized medicine demand, in addition, passing through preset fixed plate and screw
Hole repairs ontology for Segmental Bone Defect and provides incipient stability, and improves the accuracy rate of screw placement, reduces fluoroscopy during operation
Number.
The reparation body supporting piece is that Segmental Bone Defect reparation ontology 1 provides mechanical support.
In a preferred embodiment, further include in following technical characteristic at least one of:
1) the reparation body supporting piece 2 and the fixed plate 3 include following raw material and mass percent:
60~100wt% of polyether-ether-ketone, 0~40wt% of hydroxyapatite；Alternatively,
70~100wt% of polyether-ether-ketone, 0~30wt% of carbon fiber；
Polyether-ether-ketone not only good biocompatibility, no metal artifacts additionally have that antifatigue, wear-resisting, density is light, elasticity
The advantages such as model and bone are close, it is considered to be can replace ideal sclerous tissues' implantation material of metal；
2) it includes following raw material and mass percent that the Segmental Bone Defect, which repairs ontology 1:
50~100wt% of biodegradable polymer；
0~50wt% of bioactive metal.
The Segmental Bone Defect repairs the bioactive metal that ontology 1 releasably promotes Bone Defect Repari, improves the segment
Property bone defect healing ontology osseointegration character.
In a preferred embodiment, feature 2) in, the biodegradable polymer is in PCL, PLA and PLGA
At least one, the bioactive metal is selected from least one of Mg, Cu, Fe, Zn and Sr.
In a preferred embodiment, further include in following technical characteristic at least one of:
1) as shown in figure 3, the reparation body supporting piece 2, which wraps up the Segmental Bone Defect, repairs ontology 1, in the section
The position that section property bone defect healing ontology 1 is contacted with sclerotin is equipped with the first Bone Ingrowth open ports 21 and the second Bone Ingrowth open ports
22；
2) fixed plate 3 is successively arranged the first plate segment 32, the second plate segment 33 and third plate segment 34, institute
It states and repairs body supporting piece 2 in second plate segment 33, it is fixed that several described screw holes 31 are set to described first
In plate section 32 and the third plate segment 34.
In a preferred embodiment, feature 2) in, at least provided with two screw holes 31 in the fixed plate 3, wherein
One screw hole is set in first plate segment 32, another screw hole is set in the third plate segment 34.
In a preferred embodiment, the reparation body supporting piece 2 and the fixed plate 3 are integral, and reduce it
The use of his fixed plate reduces second operation and takes out.
In a preferred embodiment, as depicted in figs. 1 and 2, bone defect healing ontology 1 described above includes several
Rack-layer 11, the shelf layer 1 include several parallel bracket fins 111, and the bracket fin 11 of different layers intersects in adjacent layer, leads to
It crosses several shelf layers and bracket fin constitutes micropore, there is the micropore conducive to Bone Ingrowth, it is preferable that releasable promotion Bone Defect Repari
Bioactive metal improves the Segmental Bone Defect and repairs ontology osseointegration character.
In a preferred embodiment, further include in following technical characteristic at least one of:
1) as depicted in figs. 1 and 2,11 parallel arrangement of bracket fin in two layers of shelf layer of every phase alternating floor shelf layer；
2) angle [alpha] that as depicted in figs. 1 and 2, the bracket fin 11 of different layers intersects in adjacent layer is 45~90 °；
3) aperture of micropore is 100 μm~1000 μm；Even more preferably, the aperture of micropore is 300 μm~900 μm；
4) porosity of bone defect healing ontology 1 is 40%~90%；Even more preferably, bone defect healing ontology 1
Porosity be 60%~80%.Pore volume and bone defect healing ontology are certainly in the porosity Phalanx defect reparation ontology
The percentage of total volume under right state.
Second aspect of the present invention provides the preparation method of above-mentioned Segmental Bone Defect prosthetic device, includes the following steps:
1) bone defect area form is obtained by CT scan；
2) prosthetic device modeling is to obtain prosthetic device model (such as CAD model), and the prosthetic device model is with step 1)
Obtained bone defect area form is outer profile；
3) 3D printing is carried out according to prosthetic device model.
In a preferred embodiment, 2 spray heads are used when 3D printing, a spray head is supported for the reparation ontology
Part 2 and the fixed plate 3, another spray head repair ontology 1 for printing the Segmental Bone Defect.
The Segmental Bone Defect prosthetic device, processing are obtained by computer aided design and manufacture and 3D printing technique
Time is short, at low cost, and it is defect that the Segmental Bone Defect, which repairs ontology 1 and the global shape for repairing body supporting piece 2,
The shape of bone tissue meets personalized medicine demand.
The reparation body supporting piece 2 and the fixed plate 3 are integral, and the Segmental Bone Defect repairs ontology 1 can
To be printed jointly with the reparation body supporting piece 2, the fixed plate 3, it can also separate and print, then again by the Segmental Bone
Defect repair ontology 1 is placed on the Segmental Bone Defect and repairs in ontology 1.
Embodiment 1
A kind of Segmental Bone Defect prosthetic device, including Segmental Bone Defect repair ontology 1, repair 2 and of body supporting piece
Fixed plate 3, the Segmental Bone Defect are repaired ontology 1 and are set in the reparation body supporting piece 2, the reparation body supporting piece
2 are set in the fixed plate 3.The fixed plate 3 is successively arranged the first plate segment 32, the second plate segment 33 and third and fixes
Plate section 34, the reparation body supporting piece 2 are set in second plate segment 33, and it is solid that the screw hole 31 is set to described first
In fixed board section 32 and the third plate segment 34.It is set in the fixed plate 3 there are two screw hole 31, one of screw hole is set
In in first plate segment 32, another screw hole is set in the third plate segment 34.The Segmental Bone Defect
It repairs ontology 1 and the global shape for repairing body supporting piece 2 is the shape of defect bone tissue.The reparation body supporting piece
The 2 package Segmental Bone Defects repair ontology 1, repair the position that ontology 1 is contacted with sclerotin in the Segmental Bone Defect and set
There are the first Bone Ingrowth open ports 21 and the second Bone Ingrowth open ports 22.The reparation body supporting piece 2 and the fixed plate 3 are one
It is whole.The bone defect healing ontology 1 includes several shelf layers 11, and the shelf layer 1 includes several parallel bracket fins
111, the bracket fin 11 of different layers intersects in adjacent layer, constitutes micropore by several shelf layers and bracket fin, is often separated by one
11 parallel arrangement of bracket fin in two layers of shelf layer of layer shelf layer, the angle that the bracket fin 11 of different layers intersects in adjacent layer
Spending α is 90 °, and the aperture of micropore is 600 μm, and the porosity of bone defect healing ontology 1 is 70%.
The body supporting piece 2 and the raw material of the fixed plate 3 of repairing is polyether-ether-ketone；
It includes following raw material and mass percent that the Segmental Bone Defect, which repairs ontology 1:
Biodegradable polymer PCL 90wt%；
Bioactive metal Mg 10wt%.
Preparation method includes the following steps:
1) bone defect area form is obtained by CT scan；
2) prosthetic device modeling is to obtain prosthetic device model, the bone defect that the prosthetic device model is obtained with step 1)
Area's form is outer profile；
3) 3D printing is carried out according to prosthetic device model, 2 spray heads is used when 3D printing, a spray head is used for the reparation
Body supporting piece 2 and the fixed plate 3, another spray head repair ontology 1 for printing the Segmental Bone Defect.
In use, as shown in figure 3, the Segmental Bone Defect, which repairs ontology 1 and repairs body supporting piece 2, is set to segmental
At bone defect, screw 4 is inserted into the screw hole 31 in preset fixed plate 3, is connect with patient's sclerotin 5.
The above-described embodiments merely illustrate the principles and effects of the present invention, and is not intended to limit the present invention.It is any ripe
The personage for knowing this technology all without departing from the spirit and scope of the present invention, carries out modifications and changes to above-described embodiment.Cause
This, institute is complete without departing from the spirit and technical ideas disclosed in the present invention by those of ordinary skill in the art such as
At all equivalent modifications or change, should be covered by the claims of the present invention.
Claims (10)
1. a kind of Segmental Bone Defect prosthetic device, which is characterized in that repair ontology (1) including Segmental Bone Defect, repair this
Body supporting element (2) and fixed plate (3), the Segmental Bone Defect repair ontology (1) and are set to the reparation body supporting piece (2)
Interior, the reparation body supporting piece (2) is set on the fixed plate (3), is additionally provided with several screw holes on the fixed plate (3)
(31), it is defect bone tissue that the Segmental Bone Defect, which repairs ontology (1) and the global shape for repairing body supporting piece (2),
Shape.
2. Segmental Bone Defect prosthetic device as described in claim 1, which is characterized in that further include in following technical characteristic
At least one of:
1) the reparation body supporting piece (2) and the fixed plate (3) include following raw material and mass percent:
60~100wt% of polyether-ether-ketone, 0~40wt% of hydroxyapatite；Alternatively,
70~100wt% of polyether-ether-ketone, 0~30wt% of carbon fiber；
2) it includes following raw material and mass percent that the Segmental Bone Defect, which repairs ontology (1):
50~100wt% of biodegradable polymer；
0~50wt% of bioactive metal.
3. Segmental Bone Defect prosthetic device as claimed in claim 2, which is characterized in that feature 2) in, the biology can drop
The object that depolymerizes is selected from PCL, at least one of PLA and PLGA, and the bioactive metal is in Mg, Cu, Fe, Zn and Sr
It is at least one.
4. Segmental Bone Defect prosthetic device as described in claim 1, which is characterized in that further include in following technical characteristic
At least one of:
1) the reparation body supporting piece (2) wraps up the Segmental Bone Defect and repairs ontology (1), in the Segmental Bone Defect
It repairs the position that ontology (1) is contacted with sclerotin and is equipped with the first Bone Ingrowth open ports (21) and the second Bone Ingrowth open ports (22)；
2) fixed plate (3) is successively arranged the first plate segment (32), the second plate segment (33) and third plate segment
(34), the reparation body supporting piece (2) is set on second plate segment (33), several described screw holes (31) are set to
On first plate segment (32) and the third plate segment (34).
5. Segmental Bone Defect prosthetic device as claimed in claim 4, which is characterized in that feature 2) in, the fixed plate (3)
On at least provided with two screw holes (31), one of screw hole is set on first plate segment (32), another screw
Hole is set on the third plate segment (34).
6. Segmental Bone Defect prosthetic device as described in claim 1, which is characterized in that the reparation body supporting piece (2)
It is integral with the fixed plate (3).
7. such as Segmental Bone Defect prosthetic device as claimed in any one of claims 1 to 6, which is characterized in that the bone defect is repaired
Duplicate body (1) includes several shelf layers (11), and the shelf layer (1) includes several parallel bracket fins (111), in adjacent layer
The bracket fin (11) of different layers intersects, and constitutes micropore by several shelf layers and bracket fin.
8. Segmental Bone Defect prosthetic device as claimed in claim 7, which is characterized in that further include in following technical characteristic
At least one of:
1) bracket fin (11) parallel arrangement in two layers of shelf layer of every phase alternating floor shelf layer；
2) angle [alpha] that the bracket fin (11) of different layers intersects in adjacent layer is 30~90 °；
3) aperture of micropore is 100 μm~1000 μm；
4) porosity of bone defect healing ontology (1) is 40%~90%.
9. the preparation method of Segmental Bone Defect prosthetic device as claimed in any one of claims 1 to 8, which is characterized in that packet
Include following steps:
1) bone defect area form is obtained by CT scan；
2) prosthetic device modeling is to obtain prosthetic device model, the bone defect area shape that the prosthetic device model is obtained with step 1)
State is outer profile；
3) 3D printing is carried out according to prosthetic device model.
10. the preparation method of the prosthetic device of bone defect as claimed in claim 9, which is characterized in that use 2 when 3D printing
Spray head, a spray head are used for the reparation body supporting piece (2) and the fixed plate (3), another spray head is described for printing
Segmental Bone Defect repairs ontology (1).
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| CN201910189718.2A CN110151362A (en) | 2019-03-13 | 2019-03-13 | A kind of Segmental Bone Defect prosthetic device of 3D printing and preparation method thereof |
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